Digital Commons Network^™

Cauda Equina Syndrome: A Survey Of Guideline Utilisation In Primary Care In England, Jonathon Gill, Sue Greenhalgh, Jos M. Latour, Gillian Yeowell

School of Nursing and Midwifery

Background: Cauda equina syndrome (CES) is a spinal emergency. Over half of known cases first present to primary care for initial assessment. In February 2023, the Getting It Right First Time (GIRFT) national programme launched new CES guidelines, which included an important change in practice: a new urgent referral route. Aim: This study aims to explore the awareness and use of the GIRFT guidelines in a primary care setting in England. Design and Setting: A cross-sectional online survey was used to collect data from primary care clinicians working across England. Method: Using purposive sampling, the survey was shared with primary …

Global Tracking Of Marine Megafauna Space Use Reveals How To Achieve Conservation Targets, Ana M.M. Sequeira, Jorge P. Rodríguez, Sarah A. Marley, Hannah J. Calich, Mirjam Van Der Mheen, Michelle Vancompernolle, Lucy M. Arrowsmith, Lauren R. Peel, Nuno Queiroz, Marisa Vedor, Ivo Da Costa, Gonzalo Mucientes, Ana Couto, Nicolas E. Humphries, Sara Abalo-Morla, Scott R. Benson, Scott A. Shaffer, For Full Author List, See Comments Below

Faculty Research, Scholarly, and Creative Activity

The recent Kunming-Montreal Global Biodiversity Framework (GBF) sets ambitious goals but no clear pathway for how zero loss of important biodiversity areas and halting human-induced extinction of threatened species will be achieved. We assembled a multi-taxa tracking dataset (11 million geopositions from 15,845 tracked individuals across 121 species) to provide a global assessment of space use of highly mobile marine megafauna, showing that 63% of the area that they cover is used 80% of the time as important migratory corridors or residence areas. The GBF 30% threshold (Target 3) will be insufficient for marine megafauna’s effective conservation, leaving important areas …

Variants In Bsn, Encoding The Presynaptic Protein Bassoon, Result In A Distinct Neurodevelopmental Disorder With A Broad Phenotypic Range, Stacy G Guzman, Sarah M Ruggiero, Shiva Ganesan, Colin A Ellis, Alicia G Harrison, Katie R Sullivan, Zornitza Stark, Natasha J Brown, Sajel L Kana, Anabelle Tuttle, Jair Tenorio, Pablo Lapunzina, Julián Nevado, Marie T Mcdonald, Courtney Jensen, Patricia G Wheeler, Lila Stange, Jennifer Morrison, Boris Keren, Solveig Heide, Meg W Keating, Kameryn M Butler, Mike A Lyons, Shailly Jain, Mehdi Yeganeh, Michelle L Thompson, Molly Schroeder, Hoanh Nguyen, Jorge Granadillo, Kari M Johnston, Chaya N Murali, Katie Bosanko, T Andrew Burrow, Chop Birth Defects Biorepository, Penn Medicine Biobank, Syreeta Morgan, Deborah J Watson, Hakon Hakonarson, Ingo Helbig

Faculty, Staff and Students Publications

Disease-causing variants in synaptic function genes are a common cause of neurodevelopmental disorders (NDDs) and epilepsy. Here, we describe 14 individuals with de novo disruptive variants in BSN, which encodes the presynaptic protein Bassoon. To expand the phenotypic spectrum, we identified 15 additional individuals with protein-truncating variants (PTVs) from large biobanks. Clinical features were standardized using the Human Phenotype Ontology (HPO) across all 29 individuals, which revealed common clinical characteristics including epilepsy (13/29, 45%), febrile seizures (7/29, 25%), generalized tonic-clonic seizures (5/29, 17%), and focal-onset seizures (3/29, 10%). Behavioral phenotypes were present in almost half of all individuals (14/29, 48%), …

Loss Of Function Of The Zinc Finger Homeobox 4 Gene, Zfhx4, Underlies A Neurodevelopmental Disorder, María Del Rocío Pérez Baca, María Palomares-Bralo, Michiel Vanhooydonck, Lisa Hamerlinck, Eva D'Haene, Sebastian Leimbacher, Eva Z Jacobs, Laurenz De Cock, Erika D'Haenens, Annelies Dheedene, Zoë Malfait, Lies Vantomme, Ananilia Silva, Kathleen Rooney, Xiaonan Zhao, Amir Hossein Saeidian, Nichole Marie Owen, Fernando Santos-Simarro, Roser Lleuger-Pujol, Sixto García-Miñaúr, Itsaso Losantos-García, Björn Menten, Gaia Gestri, Nicola Ragge, Bekim Sadikovic, Elke Bogaert, Kris Vleminckx, Thomas Naert, Delfien Syx, Bert Callewaert, Sarah Vergult

Faculty, Staff and Students Publications

8q21.11 microdeletions involving ZFHX4 have previously been associated with a syndromic form of intellectual disability, hypotonia, unstable gait, and hearing loss. We report on 63 individuals-57 probands and 6 affected family members-with protein-truncating variants (n = 41), (micro)deletions (n = 21), or an inversion (n = 1) affecting ZFHX4. Probands display variable developmental delay and intellectual disability, distinctive facial characteristics, morphological abnormalities of the central nervous system, behavioral alterations, short stature, hypotonia, and occasionally cleft palate and anterior segment dysgenesis. The phenotypes associated with 8q21.11 microdeletions and ZFHX4 intragenic loss-of-function (LoF) variants largely overlap, although leukocyte-derived DNA shows a mild …

Childhood Myopia Part Ii: Treatment Mechanisms, Emerging Options, And Considerations, Safal Khanal Dr, Erin S. Tomiyama Dr, Síofra Harrington Dr

Articles

Abstract

The rapidly increasing prevalence of myopia and its association with vision-threatening complications in later life has intensified efforts to identify treatments that can prevent the onset and slow the progression of myopia in children. These efforts have led to the development of several optical, environmental, and pharmacological myopia control treatments. Investigations of additional treatment options are ongoing and have shown great promise for clinical translation. Although significant progress has been made in identifying potential pathways and modes of action of these treatments, a complete mechanistic understanding is still lacking. This critical review article explores the potential mechanisms underlying the …

Childhood Myopia Part I: Contemporary Treatment Options., Safal Khanal Dr, Erin S. Tomiyama Dr, Síofra Harrington Dr

Articles

Abstract

Childhood myopia is a growing global public health concern. Treatments to control myopia are a priority because myopia, particularly high myopia, poses significant lifelong risks of vision loss from myopia-associated ocular pathologies. Intensive research efforts over the past two decades have led to the development of several effective strategies for controlling myopia in children: increased time outdoors, atropine eye drops, dual-focus and multifocal contact lenses, orthokeratology lenses, and specialized spectacle lenses. While the efficacy of these strategies is variable, evidence is growing regarding the potential benefits of applying these interventions in children with myopia, although none completely halt myopia …

Special Issue, Nanolab Research Centre Student Articles, Preface And Contents, Furong Tian

Level 3

No abstract provided.

The Golden Standard: Potential Of Gold Nanoparticles In Cancer Research And Therapy, Caoimhe Mcmanus, Shubhrima Ghosh Dr.

Level 3

No abstract provided.

Development Of Antimicrobial Formulations From Natural Extracts And Zinc Nanoparticles, Mia Keane, Lily Jaiswal, Shiv Shankar

Level 3

No abstract provided.

Cognition And Behavior In Neurofibromatosis Type 1: Report And Perspective From The Cognition And Behavior In Nf1 (Cabin) Task Force, David H Gutmann, Corina Anastasaki, Aditi Gupta, Yang Hou, Stephanie M Morris, Jonathan M Payne, Jacob Raber, Seth M Tomchik, Linda Van Aelst, James A Walker, Kaleb H Yohay

2020-Current year OA Pubs

Individuals with neurofibromatosis type 1 (NF1) are prone to the evolution of neurodevelopmental symptomatology including motor delays, learning disabilities, autism, and attention deficits. Caused by heterozygous germline mutations in the

Psilocybin's Acute And Persistent Brain Effects: A Precision Imaging Drug Trial, Subha Subramanian, Travis Rick Reneau, Demetrius Perry, Ravi Chacko, Timothy O Laumann, Karin Flavin, Christine Horan, Julie Schweiger, Nicholas Metcalf, Eric J Lenze, Abraham Z Snyder, Nico U F Dosenbach, Ginger Nicol, Joshua S Siegel

2020-Current year OA Pubs

Psilocybin (PSIL) is a psychedelic drug and a promising experimental therapeutic for many psychiatric conditions. Precision functional mapping (PFM) combines densely repeated resting state fMRI sampling and individual-specific network mapping to improve signal-to-noise ratio (SNR) and effect size in brain imaging research. We present a randomized cross-over study in which PFM was used to characterize acute and persistent effects of psilocybin or methylphenidate (MTP) on brain networks. Seven healthy volunteers (mean age 34.1 years, SD = 9.8; n = 3 females, n = 6 Caucasians) underwent (1) extensive baseline imaging, (2) imaging beginning 60-90 minutes after drug exposure, and (3) …

Television As Myth And Ritual

Communication Research Trends

Main issue abstract:

Every nation and culture finds a way to continually retell its folktales and myths. If once we did this around camp-fires and through wandering bards, today we recast our traditional stories in modem clothes through our most popular medium, television. Throughout the world the highest audience ratings are for folktale- like soap operas that embody our historical contests, heroes and villains, and, usually, happy endings. The American-produced Dallas and Dynasty are set in the old 'wild West' states ofTexas and Colorado - but extended into new frontiers of high finance and international intrigue. The BBC'sEastEnders celebrates the …

Sample Storage Method And Collection Time Effects On Horse Hair Cortisol Concentrations, Grace Robertson, Savannah Rivers, Thomas Powell, Shea Porr

Steeplechase: An ORCA Student Journal

Serum cortisol concentration is the gold standard for evaluating stress in horses. However, it can be affected by circadian rhythms, environmental factors, and other excitatory events. Hair cortisol is less subject to these variables and is less invasive to collect, but there is a lack of published information on hair cortisol concentrations in horses. The objectives of this study were to examine 1) the impact of sample storage (Room temperature vs. Frozen) and 2) the effect of collection date (spring vs. fall), on cortisol concentration in equine hair. It was hypothesized that Frozen samples would yield higher concentrations than Room …

Dementia Care: The Role Of Experiential Learning In Nursing Education, Jeannie Simpson

Wisdom & Compassion: The LUSON Journal

The escalating global prevalence of dementia necessitates enhanced educational strategies to prepare nursing students to care effectively for individuals living with dementia. Traditional methods in nursing education predominantly focus on pharmacological treatments and basic caregiving strategies, often neglecting innovative approaches like the Music & Memory® program, Virtual Dementia Tour®, and Montessori dementia. By including these innovative approaches, future nurses will be better equipped to develop and implement person-centered care for individuals living with dementia to improve their quality of life. The integration of these approaches will also meet the growing demands of dementia care, aligning with global health mandates.

Hope And Blessings: A Homeless Student’S Story, Kennedy Pazos

Wisdom & Compassion: The LUSON Journal

No abstract provided.

Exploring Prelicensure Bsn Students’ Knowledge Of Mindfulness Meditation Using A Smartphone App To Manage Stress And Promote Resilience: A Qualitative Single Case Study, Beth Kelley, Kara Schacke, Alex Boggs, Shelley Blackwood

Wisdom & Compassion: The LUSON Journal

Stress is a detrimental factor in nursing school. Stressors contribute to an unacceptable nursing student attrition rate that has risen to 30% in 2021. The problem is that prelicensure, Bachelor of Science of Nursing (BSN) students' knowledge of mindfulness meditation using a smartphone app to manage stress and promote resilience is not known. Therefore, the purpose of this qualitative case study was to explore pre-licensure, BSN students’ knowledge of mindfulness meditation using a smartphone app to manage stress and promote resilience.

Jesus: The Multispecialty Health Care Provider, Rachel A. Joseph

Wisdom & Compassion: The LUSON Journal

No abstract provided.

Children In Foster Care: Outcomes And Nursing Implications, Rachel A. Joseph, Emily Etterman

Wisdom & Compassion: The LUSON Journal

Background: Approximately 407,000 children remained in the foster care system by the end of 2020, with 217,000 entering and 224,000 exiting the system. The foster care system is meant to be a temporary living arrangement for children born into or raised in non-flourishing homes. However, the uniqueness of the system and the interactions of foster parents lead to undesirable foster home situations while the child is left in the system for longer times. The child in foster care faces several adverse life events that make it difficult for the child to develop into a successful adult. Purpose: This paper examines …

The Impact Of California's Nursing Licensure Policies On Patient Care During The Los Angeles Wildfires, Rachel A. Joseph

Wisdom & Compassion: The LUSON Journal

No abstract provided.

The Irreplaceable Role Of Human-Centered Nursing Care In The Age Of Ai, Allyson Louise Brown

Wisdom & Compassion: The LUSON Journal

No abstract provided.

Volume 2, Issue 2 - Complete Issue

Wisdom & Compassion: The LUSON Journal

No abstract provided.

Evaluating The Effects Of Co₂ And Uv-B On Sporobolus Virginicus (L.) Kunth Growth Under Open Top Chamber: A Comparison Of Silicon Nanoparticle-Treated And Untreated Plants, Suhaila Humaid Ablooshi

Thesis/ Dissertation Defenses

This study looked at how silicon nanoparticles (SiNPs; 50 mg/L) affected the growth and health of Sporobolus virginicus in four different environments: normal conditions, high CO₂, UV-B radiation, and a mix of high CO₂ and UV-B. Plants treated with SiNPs showed much better growth, with more biomass, larger leaves, and better root development, regardless of what stress condition they faced (Ahmad et al., 2024). Additionally, SiNPs improved photosynthetic efficiency, as evidenced by increased levels of chlorophyll a, chlorophyll b, and carotenoids. SiNP application also reduced oxidative stress by lowering malondialdehyde (MDA) levels and enhancing antioxidant defense mechanisms through the elevated …

Changes In Insulin, Leptin, Resistin And Irisin Levels And Their Associations With Blood Pressure After An 8-Week Supervised, Online “Hiit Mama” Program Vs. Self-Performed Moderate-To-Vigorous Physical Activity During Pregnancy - A Randomized Controlled Trial, Anna Szumilewicz, Junjiang Sun, Rita Santos-Rocha, Jan Mieszkowski, Andrzej Kochanowicz

Baltic Journal of Health and Physical Activity

We aimed to determine changes in insulin, leptin, resistin, and irisin levels and their associations with blood pressure (BP) during pregnancy, following an 8-week high-intensity interval training (HIIT) or a self-performed moderate-to-vigorous physical activity (MVPA). The study involved 54 Caucasian women in uncomplicated, singleton pregnancy (age 32 ± 4 years, week of gestation 24 ± 4, mean ± SD). They were randomly allocated to the 8-week supervised, online “HIIT Mama” program (HIIT group, n = 34) or educational intervention and self-performed MVPA (EDU group, n = 20). All participants maintained normotension throughout the study. The HIIT program in-duced a statistically …

Economy Of Motion, Yatin Srinivash Ramesh Babu

be Still

This poem reflects the elegance and necessity of precision in medicine, particularly surgery, where "economy of motion" can mean the difference between life and death. Inspired by observing the intentionality of a surgeon's hands, I aimed to capture the poetry in their discipline—an artistry rooted in restraint.

Research Integrity In The Era Of Generative Artificial Intelligence, Andrea Wilson, Cheryl Burleigh

Journal of Educational Research and Practice

Protecting research integrity is crucial for maintaining trust in the scholarly record. Historically, threats to research integrity stemmed from deliberate human actions, such as data manipulation and misrepresentation. Generative artificial intelligence (GAI) is increasingly prevalent in higher education and is capable of generating research data and scholarly papers almost instantly. The immediate production of research data challenges traditional standards of academic rigor and integrity. The purpose of this study was to explore the role and impact of GAI on research integrity and the scholarly record, emphasizing the need for robust safeguards. For this study, we submitted Likert-type survey questions to …

Decade Celebrations 1994 - First National Symposium On "Health Care & Scientific Development”

University press releases and calendars

No abstract provided.

The Aga Khan University's Economic Impacts In Pakistan

University press releases and calendars

No abstract provided.

Evaluating The Profile Of Most Bacterial Species Isolated From Samples Containing Β-Lactamase Gene, Mohammed Farah Mohammed Abdelhameed, Ahmed Eltigani Almansoori, Mohamed T. Ibrahim, Fatma Al Otaibi, Louai Ahmed, R. H. Zayed

Journal of Agricultural and Marine Sciences

The primary cause of antibiotic use in dairy herds is mastitis, which requires microbiological identification for successful treatment and raises concerns due to increased antimicrobial resistance. This study aimed to highlight the profile of most bacterial species isolated from samples containing the β-lactamase gene from a dairy farm located in Dubai Emirate, UAE. We aseptically obtained a total of 83 milk samples from the herd of 9,000 Holstein milking cows that had clinically confirmed mastitis in March and April 2019. The real-time PCR and DNA extraction were done using the King Fisher™ Duo Prime Purification System, the Mag MAX™ CORE …

Productivity Of Common Bean (Phaseolus Vulgaris L.) And Availability Of Phosphorous Under Different Sources Of Phosphorous, Walelign Demisie, Tesfu Mengistu, Tigist Abrham

Journal of Agricultural and Marine Sciences

Common bean is the most widely grown nutritious pulse in the world and is favored by small-scale farmers in Ethiopia to ensure food security. However, the crop yield is low due to the lesser availability of phosphorous (P) in soil caused by P fixation (formation of insoluble compounds due to reaction of P with other minerals), and use of mineral fertilizers at a rate less than recommended because they are unaffordable for the poor farmers. Thus, a pot experiment was conducted to investigate the effect of different source of P on productivity of common bean and availability of P. An …

Current Practice In The Provision Of Psychological Assessment, Catherine R. Hanigan, Linda J. Baum, Anderson B. Rowan

Archives of Assessment Psychology

Understanding the assessment practices of psychologists has been a focus of research since the mid-twentieth century. Previous studies focused on the types of tests utilized as well as the amount of time spent on assessment. This updated research examined professional psychologists’ current practice and use of assessment, such as specific test usage, time spent on assessment, and feedback practices. A survey instrument was created, piloted, and administered to a sample of 293 currently practicing licensed psychologists. Results indicated that current assessment practices are largely consistent with previous surveys of psychologists. The tests identified as most frequently used were the Wechsler …