Digital Commons Network^™

Foldit Education Mode, Brett Schulz

Electronic Theses and Dissertations

Foldit education mode is a puzzle campaign within the protein folding video game Foldit. Education mode, initially designed as a classroom supplement for undergraduate biochemistry courses, has been expanded to provide a more comprehensive learning tool to players without a background in biochemistry. The edited and added levels teach players about protein biochemistry through playing puzzles designed to convey information and gameplay mechanics. The new Foldit education mode campaign features 49 levels grouped into 11 categories. The campaign has 6 new levels designed specifically for education mode and 4 levels adapted from the traditional Foldit campaign for use within education …

The Improvement Regime: Public Trusts, Real Estates, And India’S Urban Futurities, Anwesha Ghosh

Articles

Over the last two decades, since scholarly writing on India witnessed an “urban turn,” numerous historians have analyzed the role of the improvement trust in the redevelopment of Indian cities in the twentieth century, most specifically those of Bombay, Calcutta, and Delhi. This paper revisits and reassesses some of their key arguments to suggest that rather than studying the “failures” of the individual trusts to foster sanitary built environments, we should pay attention to the contingent workings of the city trusts that were constitutively designed for such failures. Using a comparative analysis of the Bombay and Calcutta improvement trusts, this …

The Motivating Factors Of A Multigenerational Workplace Based On Work Values And Reinforcements, Alaina Lister

Walden Dissertations and Doctoral Studies

There are currently four generations in the workplace—Generation Z, millennials, Generation X, and baby boomers—each having its own values and motivations due to different life experiences. Leaders are facing new challenges regarding how to motivate each generation in relation to rewards, recognition, and work values. It was unknown whether there are empirical differences in motivation and leadership preferences based on generational cohort. The purpose of this study was to examine how the members of four different generations are motivated based on their preferred rewards and recognition, and the work values they hold. The targeted population were members of Generation Z, …

Embedding Mental Rehearsal In Surgery: A Comprehensive Review Of The Evidence, Josephine Walshaw, Bright Huo, Paul Barach, Philippa Banks, Adam Mcclean, Florent Lebon, Faisal Mushtaq, David Jayne, Danilo Miskovic, Marina Yiasemidou

College of Population Health Faculty Papers

BACKGROUND: Mental rehearsal (MR), the deliberate practice of skills specific to a procedure, has been successfully used in sports and music training for decades, but has not been adopted in surgery. This narrative review explores MR's role in surgical training and clinical practice, evaluating its effectiveness in motor skill acquisition, technical and non-technical skill development, and real world clinical implementation. Our aim was to assess MR's impact on both surgical education and clinical performance, while identifying the barriers to its routine adoption in surgical training.

METHODS: We searched for relevant studies on the topic and impacts of MR in surgery …

Review: The Impact Of Insurance Policy On Glp-1 Agonist Treatment, Sunsik Chang

Harrisburg University Dissertations and Theses

This study examines how healthcare system design influences access, adherence, and financial burden associated with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in high-income countries. Through a literature review of peer-reviewed articles published between 2020 and 2025, it compares outcomes across universal and multi-payer systems. Findings reveal significant disparities. For example, the 12-month persistence reaches 68% in centralized systems like Denmark, but falls to 32–46% in the U.S., largely due to financial burdens, insurance denials, and administrative barriers. Among uninsured U.S. patients, 45% report significant financial hardship while using GLP-1 RA therapy. However, only 20% of patients enrolled in high-deductible health …

Sensing Protein Structural Transitions With Microfluidic Modulation Infrared Spectroscopy, Lathan Lucas, Phoebe S Tsoi, Ananya Nair, Allan Chris M Ferreon, Josephine C Ferreon

Faculty, Staff and Students Publications

Microfluidic modulation spectroscopy-infrared (MMS) offers a label-free, high-sensitivity approach for quantifying changes in protein secondary structures under native solution conditions. MMS subtracts the solvent backgrounds from sample signals by alternately flowing proteins and matched buffers through a microfluidic chamber, yielding clear amide I spectra from microliter volumes. In this study, we validated MMS on canonical globular proteins, bovine serum albumin, mCherry, and lysozyme, demonstrating accurate detection and resolution of α-helix, β-sheet, and mixed-fold structures. Applying MMS to the intrinsically disordered protein Tau, we detected environment-driven shifts in transient conformers: both the acidic (pH 2.5) and alkaline (pH 10) conditions increased …

Is She Being “Fast?”: Exploration Of African American Women’S Experience With Sexual Objectification, Alaigra V.R. Usher

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Issues of sexual objectification have been intertwined in America’s history since enslavement. This phenomenology study aimed to explore African American women’s lived experiences with sexual objectification and to understand the essential themes and conceptualizations that African American women attribute to sexual objectification. Through semi-structured interviews with a criterion sampling of African American women, the research sought to identify core themes surrounding sexual objectification experiences. In the results of this study, it was found that this population conceptualizes their sexual objectification experiences through seven themes: Earliest Sexual Objectification Experiences (SOE), SOE, Responses to SOE, Parental Protection, Reasons for SOE, SOE places, …

Abstract 2853 Prmt7 Negatively Regulates The Expression P53 In Response To Dna Damage, Molly Niswender, Lorenzo Pessi, Cecilia Lopez, Marco Bisoffi

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Protein Arginine Methyltransferase 7 (PRMT7) is the only member of the protein arginine methyltransferase protein family that monomethylates its protein substrates. PRMT7 is found in both the nucleus and cytoplasm of breast cells and is believed to play a robust role in the tumorigenesis and metastasis of breast cancer. The goal of this project is to uncover possible pathways for PRMT7 to promote cancer progression. A preliminary antibody array was performed to determine the regulation of known cancer-related proteins by PRMT7. An early-stage human breast cancer cell line, MCF-7, was transfected with plasmid pCDH1-hPRMT7-GFP to over-express PRMT7. Qualitative and quantitative …

A Clinical Practice Guideline For Enhanced Rehabilitation Assessment In Poststroke Patients, Chanda Honeywood

Walden Dissertations and Doctoral Studies

This doctoral project aimed to develop clinical practice guidelines (CPG) to strengthen the assessment of poststroke patients for rehabilitation. The project sought to adopt an evidence-based approach to develop standardized recommendations that can help in the timely and appropriate rehabilitation of stroke survivors, thereby reducing the risk of long-term disability and readmissions. Stroke is a significant cause of disability and poor functional recovery, increased healthcare costs, and lower quality of life for patients occur because of poor rehabilitation assessment. While rehabilitation protocols already exist, discrepancies in patient evaluations result in intervention delays and ineffective uptake of rehabilitation programs, limiting the …

Political Ecologies Of The Livestock Industry, Jecca Bowen

Electronic Theses and Dissertations

In the United States today, livestock production is dominated by an intensified, industrialized production paradigm whose growth in recent decades has utterly transformed the logistical realities and community impacts of animal agriculture. This dissertation investigates the effects of this production paradigm on livestock producers—whose decision-making is shaped by multi-scalar and often contradictory forces—as well as residents living near these large operations. To do so, I draw upon mixed-methods fieldwork, including in-depth interviews, spatial analysis, and field odor measurements in Weld and Morgan Counties in northern Colorado. I also use political ecologies of emotion, embodiment, and health to examine the complex …

The Positivity Effect In Contracts, Megan Kathryn Stricker

College of Science and Health Theses and Dissertations

The positivity effect is a noted preference for positive information over negative information in older adults’ cognition. This effect has been observed in multiple domains of cognition, including both attention and memory (Carstensen & Mikels, 2005). Evidence for the positivity effect has shown up consistently in replications across type of memory (Reed et al., 2014), and this phenomenon can be considered within the context of other trends of cognitive aging. Most if not all research in this area has been constrained to laboratory settings, and there has been limited research as to the context sensitivity of this observed effect. What …

The Relationship Of Organizational Democracy And Psychological Safety On Organizational Citizenship Behaviors, Thomas William Rice

College of Science and Health Theses and Dissertations

This study examines the relationship between organizational democracy and organizational citizenship behaviors through the mediating effect of psychological safety. This study contributes to the organizational democracy literature in the introduction of psychological safety as a mediator through the lens of social exchange theory. An online survey was completed by 245 participants who self-reported as being full-time, English-speaking employees in the United States. The survey was composed of a demographic section and different measures of organizational democracy (i.e., perceived organizational participation and democracy questionnaire, organizational democracy scale), psychological safety, and organizational citizenship behaviors. Utilizing mediated regression analysis, results indicated that psychological …

Ud In The News June 7-13, University Of Dayton

News Releases

Sociologist Art Jipson and education law expert Charles Russo contributed to The Conversation and School Business Now, respectively. Regional and local media highlighted UD research, the Greater West Dayton Incubator and onMain.

Utilizing Spatial Criteria To High-Grade Wyoming Eor Opportunities Along Proposed Pipeline Corridors: A Value Driven Approach, Jack Borski

Geography and the Environment: Graduate Student Capstones

Oil and gas development has played a critical role in human civilization, and continues to bring drive economies around the world. One such economy is the state of Wyoming that has seen oil and gas production generally decline of the last several decades due to the depletion of high volume conventional reservoirs. A proven secondary technique such as CO2 enhanced oil recovery (EOR) may serve as a method to arrest declining production, and increase economic activity. Wyoming has recognized this opportunity, and has attempted decrease the barriers of entry for oil and gas operators to invest in field-level CO2 EOR …

Global Patterns Of Genetic Diversity And Species Delimitation In The Lichen-Forming Fungus Cladia Aggregata: A Restriction Site Associated Dna Sequencing (Rad-Seq) Analysis Across Neotropical, Australasian, And Asian Populations, John De Abreu

College of Science and Health Theses and Dissertations

Cladia aggregata is a group of lichen-forming fungi comprising multiple species which are difficult to differentiate. C. aggregata has a wide distribution on several different continents but is primarily found in the southern hemisphere. We aimed to further delimit the species complex while also investigating the relatedness of the different species, where they can be found geographically, and what phenotypic traits they possess. We used Restriction Site Associated DNA Sequencing (RAD-seq) to compare thousands of loci across 91 individuals from the Americas, Asia, and Australasia. All Asian samples formed a distinct clade in all phylogenetic trees. Asia, as a distinct …

Mental Healthcare For Us: Examining Awareness Of, Barriers To, And Recommendations For Mental Healthcare Among Immigrant-Origin Chinese American Adolescents, Mengxue (Fiona) Sun

College of Science and Health Theses and Dissertations

Background. Ethnic minority adolescents face elevated mental health challenges and encounter significant barriers to accessing mental healthcare compared to their non-Hispanic White counterparts. Despite these challenges, limited research has explored culturally responsive mental healthcare for adolescents from specific Asian American communities, and even fewer studies have actively incorporated adolescents' perspectives to inform treatment and policy. This study aimed to examine the experiences of immigrant-origin Chinese American adolescents with mental health and mental healthcare.

Method. Ten immigrant-origin Chinese American adolescents, aged 14 to 17, were recruited through community organizations and participated in semi-structured individual interviews. Open-ended questions focused on …

Enhancing Neuronal Viability: The Protective Role Of 10% Human Cerebrospinal Fluid In Primary Neuronal Cultures, Vineet Arora, Alicia Bernhardt, Alessandro Naopli, Mijail Serruya

Farber Institute for Neuroscience Faculty Papers

Human cerebrospinal fluid (hCSF) is a physiologically rich medium containing neurotrophic factors, signaling molecules, and essential metabolites that support neuronal development, survival, and function. While its neuroprotective properties have been demonstrated in organotypic brain slices and human iPSC-derived models, its application in primary rodent cortical neuron cultures-a foundational system for studying synaptic development and neurodegeneration-remains underexplored. In this study, we systematically evaluated the effects of hCSF supplementation on neuronal viability in primary cortical cultures derived from embryonic day 18 (E18) rat embryos. To determine the optimal concentration, we tested a range of media:hCSF ratios and identified 90:10 (i.e., 10% hCSF) …

Using The Token Economy To Improve Show Rates In An Outpatient/Community Mental Health Clinic, Gertrude Nabila Ndansi

Walden Dissertations and Doctoral Studies

The type of project was a quality improvement intervention. The identified practice problem was limited appointment shows among patients with appointments. Outpatient clinics often struggle with patients not showing up for appointments. Addressing this gap was critical for improving patient outcomes and resource efficiency. The practice problem must be addressed within the context of nursing practice by enhancing access to consistent mental health care and giving patients more timely support, leading to better outcomes and overall wellbeing.

Immobilization Of Bromelain On Fe3O4-Sa/Cs Microspheres And Its Enzymatic Properties, Wang Dan, Geng Lijing, Huang Wei, Fu Hang, Liu Xiaoyu

Food and Machinery

［Objective］ To improve the immobilization technology of bromelain which has poor stability to enhance its utilization,stability,and storage performance.［Methods］ The preparation process of magnetic chitosan/sodium alginate immobilized bromelain (Fe3O4-SA/CS -Br) is optimized by the response surface methodology.The Fe3O4-SA/CS -Br is characterized and its Km value,operational stability,thermal stability,storage stability,and application effectiveness are determined.［Results］ The optimal preparation conditions for Fe3O4-SA/CS -Br are as follows:mchitosan∶msodium alginate ratio of 1∶4,Fe3O4 mass concentration of 10 mg/mL,CaCl2 mass concentration of 32 mg/mL,immobilization time of 106 min,pH value of 7.0,and enzyme mass concentration of 1.0 mg/mL.According to the results from scanning electron microscopy,infrared spectrum,and X -ray diffraction spectrum,the …

Implementation And Evaluation Of A Weight Management Programme For Overweight Or Obese Pregnant Women: A Randomised Controlled Trial, Elahe Banafshe, Nahid Javadifar, Zahra Abbaspoor, Saeed Ghanbari, Majid Karandish

Sultan Qaboos University Medical Journal

Objectives: Obesity is a major health concern, particularly among women of reproductive age. This study aimed to evaluate the effectiveness of a psychosocial-based intervention on weight management and pregnancy outcomes in overweight or obese pregnant women. Methods: This randomised controlled trial included overweight or obese pregnant women from healthcare centres affiliated with Jundishapur University of Medical Sciences in Ahvaz, Iran and was conducted from June to December 2023. Participants were randomly assigned to an intervention or control group. The intervention group received a comprehensive weight management programme during pregnancy, while the control group received standard prenatal care. Results …

Il-6 Induces Cd45 Expression On Myeloid Cells, Maryam Ahmed Al Barashdi, Ahlam Ali, Mary Frances Mcmullin, Ken Mills

Sultan Qaboos University Medical Journal

Objectives: Activation of IL-6 facilitates CD45 expression in myeloma cells, but little has been reported for myeloid malignancies. This study aimed to investigate whether IL-6 enhances CD45 expression on myeloid malignancies and whether myeloid cells are dependent on IL-6 activation to express CD45 on their cell membrane. Methods: This study was conducted from January to March 2022 at the Queen's University Belfast, UK. Myeloid cell lines such as HEL and OCI-AML3 which expressed higher levels of CD45, and UT-7 and the pro-B NALM-6 cell lines that had lower CD45 levels as well as primary cells were used. The …

Enhancing Delirium Prediction And Prevention In Elderly Patients Through Machine Learning-Based Analysis, Abdullah M. Al Alawi, Juhaina S. Al Maqbali

Sultan Qaboos University Medical Journal

Objective: This study aimed to identify predictors of delirium within 24 hours of admission in elderly patients using machine learning (ML) models and evaluate their performance. Methods: This prospective cohort study was conducted among patients aged 65 years and older admitted to the general medical unit of Sultan Qaboos University Hospital, Muscat, Oman, from January 2022 to May 2023. Clinical and demographic data were collected and analysed using 4 ML models: logistic regression, random forest, gradient boosting and support vector machine. Model performance was evaluated using accuracy, precision, recall, F1 score and area under the curve-receiver operating characteristic …

Optimising Healthcare Delivery: Efficiency Analysis Of Oman’S Governorate Hospital Networks, Sultana M. Al-Sabahi, Avinash D. Pinto, Qasem Al-Salmi, Hilal A. Al-Sabti

Sultan Qaboos University Medical Journal

Objectives: This study aimed to evaluate the efficiency of the healthcare facilities in the Oman to guide the decision-making process and benchmarking. Methods: Input-oriented data envelopment analysis (DEA) was used to assess the relative efficiency of governorate hospitals in Oman using 2022 data extracted in December 2023. In the second stage of data analysis, the Tobit model was applied to assess determinants of governorate hospital inefficiency; 3 DEA models were created (staffing, structure and budget). Results: A total of 10 governorate hospitals were included in this study. The efficiency score change was small for the governorate hospitals …

Prognostic Accuracy Of Red Blood Cell Distribution Width In Predicting Mortality Among Acute Pancreatitis Patients: A Systematic Review And Hierarchical Bivariate Meta-Analysis, M.S. Deepthy, K.T. Harichandrakumar, Kalesh M. Karun, Tamilarasu Kadhiravan, N. S. Nair

Sultan Qaboos University Medical Journal

Acute pancreatitis (AP), often requiring hospitalisation, is mild in most cases but severe in approximately 20% of cases. Early severity and mortality risk identification are crucial. This systematic review and meta-analysis evaluated the prognostic utility of red blood cell distribution width (RDW) for predicting mortality in AP. A comprehensive literature search from 1990 to 2023 was conducted across MEDLINE, SCOPUS and ScienceDirect databases along with Google Scholar. Methodological quality of included studies was assessed using the Quality in Prognostic Studies tool. Prognostic accuracy measures were pooled using a bivariate random-effects meta-analysis model, and hierarchical summary receiver operating characteristic (ROC) curve …

Chest Wall Chondromyxoid Fibroma: A Case Report And Literature Review, Waad Al Farsi, Yaseen Al Lawati, Hilal Al Sabti, Zakiya Al Ajmi, Humaid Al Farii

Sultan Qaboos University Medical Journal

Chondromyxoid fibromas (CMFs) are rare tumours that comprise less than 2% of benign bone tumours; approximately 5-7.9% occur in the ribs. We report a 28-year-old female patient with CMF in the 4th rib that presented to a tertiary care hospital in Muscat, Oman, in 2023. She complained of pain in the right posterior chest wall for 6 months. A chest computed tomography showed posterior 4th rib expansile lesion measuring 3×2 cm without soft tissue involvement. A percutaneous biopsy suggested a diagnosis of chondomyxoid fibroma. The tumour was resected with a free-margin and assistance of video-assisted thoracic surgery approach. The diagnosis …

A Systematic Review And Meta-Analysis On The Role Of Somatostatin Therapy In Non-Variceal Gastrointestinal Bleeding, Magnus Chun, Tahne Vongsavath, Sneh Sonaiya, Lily Liu, Kyaw Min Tun, Kavita Batra, Robert G. Gish

Department of Internal Medicine Faculty Research

Background and Aims: Non-variceal upper gastrointestinal bleeding (NVUGIB) is a common cause of hospitalizations, with proton pump inhibitors (PPIs) being the mainstay treatment. However, there is a lack of high-level evidence to show if adjunctive medical therapy (somatostatin and its analogs) can improve outcomes. This systematic review and meta-analysis aim to evaluate the outcomes of PPIs with adjunctive therapy versus PPI monotherapy in treating NVUGIB in an in-patient setting. Methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist, major databases were systematically searched to retrieve English-only, original studies, published from 1 January 2000 to 31 December …

Clinical Profile Of Patients With Monocular Elevation Deficiency Undergoing Strabismus Surgery, Mohamad Reza Akbari, Babak Masoomian, Elham Azizi, Mohammed Omer Mahmood, Arash Mirmohammadsadeghi, Ali Majdi, Masoud Khorrami-Nejad

Wills Eye Hospital Papers

PURPOSE: To provide a comprehensive evaluation of the visual, refractive, and strabismic characteristics of patients with monocular elevation deficiency (MED) undergoing strabismus surgery.

METHODS: The medical records of patients at a single institution who were diagnosed with and underwent surgery for MED were reviewed retrospectively. Visual acuity, refractive error, angle of deviation, abnormal head posture (AHP), presence of ptosis, prevalence of amblyopia and strabismic patterns were analyzed, with MED eyes compared with fellow eyes.

RESULTS: A total of 105 patients were included. Mean cylindrical refractive error was significantly higher in MED eyes compared with fellow eyes (-1.40 ± 1.70 D …

Exploring The Relationship Between Country Socioeconomic Characteristics And Electronic Waste, Keliiakekaipuka Aria Mccomber

Theses and Dissertations

Electrical and electronic waste (e-waste) is one of the fastest-growing and most hazardous waste streams globally. Despite efforts to improve global e-waste management, 77.7 percent of e-waste remains improperly disposed of, particularly in low- and middle-income countries where environmental and health risks are greatest (Baldé et al., 2024). This study evaluates whether national socioeconomic, cultural, and governmental characteristics can predict three key e-waste outcomes: generation per capita, formal collection rates, and resulting burden per capita. Using data from 2015-2022 for 127 countries, we applied mixed effects models incorporating variables such as GDP, Human Development Index, institutional integrity, financial openness, and …

Between Breaths: Healing And Being, Corina Yu Zhao

Journal of Wellness

Burnout among healthcare professionals is an increasingly recognized crisis, yet pathways to resilience remain underexplored. This narrative chronicles the author’s personal journey from profound exhaustion to self-discovery and renewal. Through the integration of contemplative practices, nature exposure, and mindful nourishment, the author navigated the challenges of residency and emerged with a deeper understanding of well-being. By incorporating Isha Kriya meditation, Surya Kriya yoga, and self-inquiry practices rooted in Advaita Vedanta, the experience evolved into a transformative path of inner resilience. This report highlights the necessity of prioritizing self-care within the medical profession and offers evidence-backed insights into holistic wellness practices, …

We Are Still Here: Intersectional Collaborations In Research, Practice, And Resistance Among Mfp Scholars, Antonia R.G. Alvarez, Sameena Azhar, Tyrone M. Parchment, Judith Perrigo, Anne S. J. Farina, Tania Paredes, Jonathan P. Edwards, Susan Klumpner

School of Social Work Faculty Publications and Presentations

As Council on Social Work Education (CSWE) Minority Fellowship Program (MFP) scholars, we formed meaningful connections as academics, students, and friends. Throughout this reflective article, we explore the profound impact of our intersectional and critical race-informed scholarship on our professional practice and pedagogy while highlighting the ways that collaborating on this work enriched our journeys as scholars of color. These collaborations have expanded our perspectives and fostered new ways of thinking about the unique health and mental health experiences of ethnoracial communities. Through these partnerships, we have advanced diverse scientific literature and addressed critical gaps within the existing canon of …