Digital Commons Network^™

Human Alveolar Macrophage Response To Mycobacterium Tuberculosis: Immune Characteristics Underlying Large Inter-Individual Variability, Wolfgang Sadee, Ian H. Cheeseman, Audrey Papp, Maciej Pietrzak, Michal Seweryn, Xiaofei Zhou, Shili Lin, Hao Zhang, Blanca I. Restrepo, Yufeng Wang

School of Medicine Publications

Mycobacterium tuberculosis (M.tb) infection infects human alveolar macrophages (HAMs). In freshly isolated HAMs from 28 healthy adults, we observe large inter-individual differences in bacterial uptake and growth, with tenfold variation in M.tb load by 72 h. While M.tb infection triggers expression changes of numerous host mRNAs, we examined which genes are most variably expressed (VE genes) between donors, as potential biomarkers of individual tuberculosis (TB) risk. The HAM RNA transcriptome following infection revealed thousands of differentially expressed (DE) genes and differential secretion of 25/27 proteins. Yet only 324 DE genes represent VE genes detected exclusively among DE genes in …

Restorative Justice In Legal Education, Lindsey Pointer, Aparna Polavarapu, Alanna Ojibway

Journal of Legal Education

No abstract provided.

Incorporating Restorative Justice Into Black-Letter Criminal Law, Shirin Bakhshay

Journal of Legal Education

No abstract provided.

Implementation Insights: Learning From Integrating Restorative Justice In The National Academy Of Legal Studies And Research (Nalsar), Hyderabad, India, Arti Mohan

Journal of Legal Education

No abstract provided.

"Will The Circle Be Unbroken": The Role Of Law School Centers In Advancing Restorative Justice Theory, Practice, And Education, Deborah Thompson Eisenberg, Toby Treem Guerin

Journal of Legal Education

No abstract provided.

Redemption Song: Listening For Justice At An Hbcu Law School, Scott Holmes, Joy Clark

Journal of Legal Education

No abstract provided.

Reflections On Teaching Restorative Justice As A Racial Justice Tool, Mary Louise Frampton

Journal of Legal Education

No abstract provided.

Enhancing Education In Nursing Skills: The Impact Of Simulation Use On Faculty Self -Efficacy, Annie Kyle

Doctor of Nursing Practice Projects

This quality improvement (QI) project aimed to improve nursing faculty self-efficacy in teaching nursing skills using medium- and high-fidelity simulation. The problem addressed was the increasing number of students requiring multiple attempts to pass skills checkoffs, with some ultimately being withdrawn from the program. Faculty at the project site reported a lack of training and confidence in utilizing simulation technology effectively. A quasi-experimental design was used with a single group of full-time faculty (n=6), who received simulation training and completed the Self-Efficacy Towards Teaching Inventory for Nurse Educators (SETTI-NE) before and after the intervention. The data analysis was conducted using …

Improving Patient Outcomes Post-Discharge: Implementing Evidence-Based Discharge Planning For High-Risk Mental Health And Substance Use Disorder Populations, Margaret Phillips

Doctor of Nursing Practice Projects

A significant gap in standardized discharge procedures was identified at a nonprofit, community-based clinic serving male residential patients with substance use disorder (SUD) and co-occurring mental health conditions. The lack of a standardized discharge process led to poor follow-up appointment adherence, poor medication adherence and increased risk of relapse. This quality improvement (QI) project aimed to address these issues through the implementation of a cross-departmental discharge process that produced tailored Individualized Discharge Plans (IDP) or each patient, using the Donabedian and Kotter’s 8-Step Change models as guiding frameworks. Data were collected using custom-built tracking tools over two four-week periods, pre- …

Magic Or Morass?: A Multidisciplinary Approach To Restorative Practices For Sexual Harm Prevention And Program Evaluation, C. Quince Hopkins, Laurie M. Graham, April Cavaletto

Journal of Legal Education

No abstract provided.

Design-Build Capstone Projects: Continuing The Poly Canyon Legacy Of Learn-By-Doing, Anahid A. Behrouzi, Brayden A. Martinez, William R. Adam

Architectural Engineering

In the 1960s around ten acres of land behind the main campus of California Polytechnic State University in San Luis Obispo were set aside for students from the College of Architecture and Environmental Design to experiment with structural forms, materials, and construction methods. The publicly accessible Poly Canyon site has amassed a collection of structures: bridges crossing a seasonal creek, caretaker housing, a greenhouse, multiple sculptures and observation structures, among others. There were ebbs and flows of construction activity in Poly Canyon, often seeing a decade of activity with as much time dormant in between.

This paper focuses on the …

Cancer Immunotherapy Clinical Trials To Support Urgently Needed Access In Low- And Middle-Income Countries: A Report From The Sitc Global Access And Impact Committee, Jennifer Dent, Thomas A Odeny, Et Al.

2020-Current year OA Pubs

Cancer is rapidly on the rise as a cause of morbidity and mortality in low- and middle-income countries (LMICs). However, despite the increasing importance of immune checkpoint inhibitors (ICIs) as a pillar of cancer therapy, access in these settings lags well behind that in high-income countries (HICs). Increasing the evaluation of ICIs through local clinical trials and demonstration projects, and inclusion in multinational clinical trials is the first step to improving access. In particular, the epidemiology and clinical presentation of cancer in LMICs is often distinct from that in HICs, and the impact of immune checkpoint blockade in these settings …

Dysferlinopathy As Cause Of Long-Term Hyperckemia With Preserved Strength, Ikreet Cheema, Jacob Goodwin, Teerin Liewluck, Robert Charles Bucelli, Alan Pestronk, Margherita Milone

2020-Current year OA Pubs

BACKGROUND: Dysferlin (DYSF) has a crucial role in sarcolemmal repair. While DYSF mutations commonly manifest as limb-girdle muscular dystrophy (LGMDR2) or distal Miyoshi myopathy, atypical manifestations, such as asymptomatic hyperCKemia and pseudometabolic myopathy, are rarely reported. We describe clinical, serologic, radiologic, genetic, and muscle pathology findings of three patients with rare dysferlinopathy phenotypes and long-term follow up in one of them. We also review the literature pertinent to uncommon forms of dysferlinopathy presenting with hyperCKemia and pseudometabolic phenotype.

RESULTS: Patient 1 is a 51-year-old female with exercise-induced myalgia predominantly affecting calf muscles for 7 years. She had a 22-year history …

Cst110.1 Analysing Everyday Interfaces Example 2, Sae University College

Exemplars

A Case Study on usability analysis of the Apple iOS fitness app.

Detecting Early Changes In Cartilage Collagen And Proteoglycans Distribution Gradients In Mice Harboring The R992c Collagen Ii Mutant Using 2d Correlation Infrared Spectroscopy, Jolanta Fertala, Andrzej Steplewski, Andrzej Fertala

Department of Orthopaedic Surgery Faculty Papers

Collagen II is a vital structural component in developing bones and mature cartilage. Muta- tions in this protein cause spondyloepiphyseal dysplasia, a disease characterized primarily by altered skeletal growth and manifesting with a range of phenotypes, from lethal to mild. This study examined transgenic mice harboring the R992C (p.R1124C) substitution in colla- gen II. Previous research demonstrated significant growth abnormalities and disorganized growth plate structure in these mice, and histological signs of osteoarthritic changes in the knee joints of 9-month-old mice with the R992C mutation. Our study focuses on detecting early structural changes in the articular cartilage that occur before …

Like Holding Up A Mirror: How I Learned To Teach Restorative Justice, Susan Abraham

Journal of Legal Education

No abstract provided.

Quality Improvement Project The Introduction Of Gratitude Journaling To Decrease Test Anxiety In Prelicensure Bachelor Of Science In Nursing Students, Jourdan Scoggins

Doctor of Nursing Practice Projects

Test anxiety is a substantial barrier to success among prelicensure nursing students, given the heavy course load and high academic pressure of the educational environment. The purpose of this quality improvement project was to measure the impact of gratitude journaling on levels of test anxiety in first-semester Bachelor of Science in Nursing (BSN) enrolled in a nursing math course at a regional university in Arkansas. Following a quasi-experimental design, students participating in the project completed the Westside Test Anxiety Scale (WTAS) before and after five weeks of gratitude journaling. Thirty-two students participated in the intervention and 24 of those completed …

Designing Electric Vehicle Infrastructures And Opportunities To Benefit All Residents, Polly Parkinson, Emma Mecham, Fawn Groves, Ivonne Santiago, Amy Wilson-Lopez

Teacher Education and Leadership Student Research

Countries around the globe have set electric vehicle adoption goals to address environmental and health concerns, but engineering planners and community policy experts cannot separate the socioeconomic factors from transportation needs. This mixed-methods case study indicates that because transportation decisions are inextricably linked to health, work, and housing, EV adoption must also address multifaceted human needs. To avoid the transportation mistakes of the past, it is essential that people in communities are consulted in the adoption process and have opportunities so all may actively benefit from the infrastructures and economic growth caused by electrification. “If you don't know the space …

Computational Model Predicts Function Of Rho-Gtpase Binding For Plexin Receptor Gap Activity On Rap1b Via Dynamic Allosteric Changes, Nisha Bhattarai

Faculty Scholarship

Plexin-semaphorin signaling regulates key processes such as cell migration, neuronal development, angiogenesis, and immune responses. Plexins stand out because they can directly bind with both Rho- and Ras-family small GTPases through their intracellular domains when these GTPases are in their active, GTP-bound states. This binding occurs via intracellular regions, which include a Rho-GTPase binding domain and a GTPase-activating protein (GAP) segment. Studies have shown that Rho and Ras GTPases play vital roles in plexin signaling and activation. However, the structural dynamics of plexins and GTPases and how these conformational changes affect interactions when plexin is bound with both Ras and …

Effect Of An Educational Program To Enhance Psychological Capital On Academic Burnout Among Nursing Students, Asmaa Metwally Elhadidy Dr

Nursing

Background: Academic burnout is a common challenge among associate degree nursing students, stemming from intensive academic and clinical demands. Psychological capital (PsyCap)—a construct encompassing self-efficacy, hope, resilience, and optimism—has emerged as a modifiable resource that may buffer against burnout. Aim: This study aimed to evaluate the effectiveness of a psycho-educational program designed to enhance psychological capital and reduce academic burnout among associate degree nursing students. Methods: A quasi-experimental pretest-posttest design was conducted with 187 second-year Associate Degree in Nursing (ADN) students. students at Ain Shams University. Students participated in a 6-month intervention consisting of 26 sessions. Burnout and PsyCap were …

Board # 271: Nsf Iuse 2315777: Training Engineering Students To Be Better Learners: A Course-Integrated Approach, Huihui Qi, C. Pilegard, Minju Kim, Saharnaz Baghdadchi, Curt Schurgers, Alex M. Phan, Marko Lubarda

Psychology Faculty Articles and Research

Learning is a lifelong process exercised within and beyond the classroom, and a vital skill in almost all technical professions. Engineers, in particular, are impacted by rapidly evolving technologies and practices that require continuous learning and adaptation long after their training and the initial transition into their professional careers. However, despite the critical role of learning in their academic success and profession, engineering students experience academically rigorous and challenging courses with minimal emphasis or conscious focus on learning strategies that power effective learning. Often-used learning strategies such as rereading, highlighting, repetition, and memorization are intuitive for many students, yet do …

Temporal Changes In Soil Organic Carbon And Other Near-Surfacesoil Properties Under Native Tallgrass Prairie In The Arkansasriver Valley, Katie Jansson, Kristofor R. Brye, Mike Richardson, Lisa S. Wood

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

One climate-change mitigation pathway is soil carbon (C) sequestration. Native prairies have long been known for their soil C sequestration abilities, but the full extent of their sequestration capacity is not completely understood, particularly across diverse regions. This study evaluated the effects of soil depth and soil map unit-prairie combination on changes in various soil properties from 2018 to 2022 in the top 20 cm of two native tallgrass prairies in west-central Arkansas. Soil bulk density, pH, electrical conductivity, total nitrogen, total C (TC), soil organic matter (SOM), and Mehlich-3 extractable soil nutrients were evaluated from the 0- to 10-cm …

Head To Head Comparison Of Two Pet/Ct Imaging Agents, [18f]D3fsp ([18f]P16-129) And [18f]Av45, In Patients With Alzheimer’S Disease, David Alexoff, Dean F Wong, Hiroto Kuwabara, Robert F Dannals, Karl Ploessl, Hank F Kung

2020-Current year OA Pubs

BACKGROUND: A new β-amyloid (Aβ) targeting radiotracer, [

RESULTS: Eight patients, clinically diagnosed with Alzheimer's disease, had an average age of 61.1 ± 10.0 years, and an average MMSE score of 21 ± 4. Each patient underwent paired 90-minute dynamic PET/CT scans separately within a few weeks (323 ± 31 MBq of [

CONCLUSIONS: Results showed no difference between [

TRIAL REGISTRATION: Clinicaltrials.org, NCT03902548. Registered 01/07/2018.

The Impact Of The Chevron Ruling On Medicare, Sana Sherali

DePaul Journal of Health Care Law

The Supreme Court’s historic decision to overturn the Chevron doctrine in June 2024 received national attention due to its implications for how much power agencies will hold in the years to come. The Chevron doctrine originally comes from the Supreme Court’s 1984 decision in Chevron, U.S.A., Inc. v. Natural Resources Defense Council.Chevron addressed the requirements imposed on states by The Clean Air Act Amendments of 1977. This decision set the precedent that if federal legislation is unclear or leaves an administrative gap, courts have to follow the regulatory agency’s interpretation of the law, as long as the interpretation is …

Heterogeneity In Hospital Consolidation, Christina Depasquale

DePaul Journal of Health Care Law

This paper examines the heterogeneity between two types of hospital consolidations—mergers and system-joinings. I examine changes in admissions, employment outcomes, beds in different medical units, surgeries, costs, case mix, and discharges. I find that hospital mergers and system-joiners are fundamentally different among almost all outcomes examined. Additionally, I extend my analysis by examining those hospitals that, at the time of consolidation, are closer to either their fellow merging hospital or a fellow system-member hospital. I find no meaningful correlation between distance and outcomes.

The Opioid Crisis: How The United States And Countries Abroad Are Making Strides, Maura Mcginnity

DePaul Journal of Health Care Law

The opioid epidemic has been an ongoing problem in the United States since the 1980s. The United States has had a very negative attitude towards individuals suffering from addiction. This attitude is clearly shown through the United States’ handling of the opioid crisis. Hundreds of thousands of individuals have died due to opioids. In the forty years since this epidemic became prevalent, the United States has still failed to implement a country-wide solution to combat the crisis. Certain states, like New York and Illinois, have made strides toward helping individuals suffering from opioid use disorder, but nationally, the country is …

Agenda (Pdf), Department Of Orthopaedic Surgery

Dept. of Orthopaedics: Robert D. D’Ambrosia Lectureship & Research Day

No abstract provided.

The Critical Definitions For Measuring Homelessness: Implication For Homeless Policy Formulation From Developed Countries To Thailand, Surasak Wongsa

Journal of Demography

Homelessness phenomenon is facing in countries. In the past, the definition of homelessness was based on a materialistic mindset or the principle of objectivity, which viewed problems as tangible and visible objects. Looking at social problems based on objectivity leads to a definition of homelessness that includes only those who are sleeping on the streets and people living in government shelters by identifying the causal factors of homelessness at the individual level, especially mental illness, crime, and drug use. Defining homelessness objectively also involves counting methods that measure the characteristics of homelessness using street counts from the locations where homeless …

The History Of The Mainehealth Institute For Research, Clifford J. Rosen Md

Histories

No abstract provided.

Quality Improvement Project Building Community Of Practice Through An Affiliate App Virtual Forum, Patricia J. Pease

Doctor of Nursing Practice Projects

Establishing community and support for pediatric hematology and oncology Advanced Practice Providers can be challenging. Asynchronous working schedules, lack of protected time, and geographical distance hinder these efforts. Extending professional support and collaboration to providers is vital to ensure communication, interprofessional teaming, and collaborative care of the high-acuity patient population. Given the availability of virtual forums, this project explores the ability of a virtual, synchronous Community of Practice (VCoP) to enhance interprofessional collaboration for affiliated Advanced Practice Providers (APPs). This project utilizes the validated Assessment of Interprofessional Team Collaboration II (AITCS-II) to assess pre- and post-intervention interprofessional collaboration via a …