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Mda At Your Service: Does The Mda Have A Source For Free Labor Law Posters?, Rachel Sinacola Dds Jul 2025

Mda At Your Service: Does The Mda Have A Source For Free Labor Law Posters?, Rachel Sinacola Dds

The Journal of the Michigan Dental Association

This "Q&A" section addresses common MDA member inquiries. It confirms that MDA members receive free labor law posters and automatic updates directly from the association. The MDA also offers affiliate memberships for dentists moving out-of-state but retaining Michigan ties, preserving benefits like discounted CE. Information is provided on the Certified Dental Business Professional (CDBP) program, which offers affordable staff certification over three years. The next Mission of Mercy is scheduled for June 11-14, 2026, in Kalamazoo. Finally, the article notes the discontinuation of the MDA Fee Survey due to antitrust changes, and directs members to the ADA/MDA Code of Ethics …


J Mich Dent Assoc July 2025 Jul 2025

J Mich Dent Assoc July 2025

The Journal of the Michigan Dental Association

Each month, The Journal of the Michigan Dental Association provides news, information, and features about Michigan dentistry to our state's oral health community and the MDA's 5,800 members. It stands as the primary publication reaching Michigan dentists. The all-digital July issue features Dr. Michele Tulak-Gorecki’s "It’s Time to Dare Greatly at the ADA," where she outlines her vision for ADA president-elect, focusing on financial integrity, strengthened advocacy, and fostering unity amidst challenges like declining membership and issues with the association management system.

Supporting articles highlight the MDA’s endorsement of MEDVA, offering cost-effective, HIPAA-compliant virtual assistant solutions for dental practices to …


The New Professional: Reimagining Rapport: Innovative Ways Dental Teams Connect With Patients, Amrita Patel Dds Jul 2025

The New Professional: Reimagining Rapport: Innovative Ways Dental Teams Connect With Patients, Amrita Patel Dds

The Journal of the Michigan Dental Association

This article explores innovative communication strategies for dental practices to enhance patient interaction. It highlights the importance of digital onboarding for streamlined intake, two-way text messaging for efficient appointments, and personalized video messages to foster connection. Practices are adopting multilingual communication and AI tools like chatbots for 24/7 inquiry handling, integrating them with patient records for tailored responses. Interactive platforms with 3D visuals and video tutorials are used for patient education, empowering them in oral health decisions. The article also emphasizes leveraging social media for engagement, capturing real-time patient feedback, and maintaining empathy-driven human interaction despite technological advancements


Mda Foundation: $10k Grant To Utica Clinic Makes Quality Dental Care Possible, Anne Berquist Jul 2025

Mda Foundation: $10k Grant To Utica Clinic Makes Quality Dental Care Possible, Anne Berquist

The Journal of the Michigan Dental Association

The MDA Foundation awarded a $10,000 grant to the Trinity Community Care Clinic in Utica, enabling them to replace an aging panoramic X-ray machine. Founded in 2011 by Dr. Robert Antolak and volunteers, this faith-based 501(c)(3) non-profit provides free or reduced-cost medical and dental care to uninsured or underinsured patients whose incomes are at or below 250% of the federal poverty level. The clinic relies on grants and donations, with dentists, hygienists, and University of Detroit Mercy dental students volunteering. Trinity Community Care offers various services, including extractions, dentures, restorations, and oral hygiene, consistently seeking more volunteers to expand its …


Dentistry And The Law: What Ever Happened To The Ban On Covenants Not To Compete?, Daniel Schulte Jd Jul 2025

Dentistry And The Law: What Ever Happened To The Ban On Covenants Not To Compete?, Daniel Schulte Jd

The Journal of the Michigan Dental Association

The Federal Trade Commission's (FTC) rule banning most employee non-competition agreements remains held up, despite a scheduled September 2024 effective date, due to ongoing court challenges with conflicting decisions. Recent changes at the FTC, including the appointment of a new chair (Andrew Ferguson) who previously opposed the ban, suggest a potential reversal or non-enforcement by the current Trump administration. While motions have been filed to hold appeals in abeyance, the FTC's formation of a new Joint Labor Task Force complicates the outlook, indicating continued focus on antitrust issues in the labor market. A clear outcome or timeline for the ban …


What To Know About Release Of Information, Authorization, And Records Requests, Jennifer Cosey Jul 2025

What To Know About Release Of Information, Authorization, And Records Requests, Jennifer Cosey

The Journal of the Michigan Dental Association

This article clarifies HIPAA regulations regarding the disclosure of protected health information (PHI). It distinguishes between a "Right of Access" request, where a patient directly seeks their own record (no authorization needed), and an "Authorization," which is required for disclosures beyond treatment, payment, or health care operations, or to third parties for ongoing access. The author details activities permissible without authorization, such as coordination of care, billing, and quality improvement. Specific examples are provided for situations requiring authorization, like disclosing PHI to attorneys or for marketing. The article also outlines seven essential elements for a HIPAA-compliant authorization form


The Relationships Between Expectancy-Value Beliefs, Communal Value Beliefs, Family Identity, And Academic Persistence Among First- And Continuing-Generation College Students, Douglas W. Snuffer Jul 2025

The Relationships Between Expectancy-Value Beliefs, Communal Value Beliefs, Family Identity, And Academic Persistence Among First- And Continuing-Generation College Students, Douglas W. Snuffer

STEMPS Theses & Dissertations

First-generation college students (students for whom neither parent has a 4-year college degree) have lower college graduation rates than their continuing-generation peers (Cahalan et al., 2021; Fry, 2021). First-generation students may experience barriers to higher education, leading to lower levels of academic achievement motivation for college. Two of these barriers may include 1) cultural mismatch (Stephens, Fryberg, et al., 2012) with colleges via communal value (a value set that emphasizes community and family over the self) and 2) a strong sense of family identity, which lends itself to perceived family obligations (Fuligni et al., 2007). To examine the relationships between …


What Approaches Can A Preschool Teacher Use To Support Their Students’ Emotional Regulation Skills?, Lydia Caldwell Jul 2025

What Approaches Can A Preschool Teacher Use To Support Their Students’ Emotional Regulation Skills?, Lydia Caldwell

School of Education and Leadership Student Capstone Projects

Emotional regulation is a foundational skill in early childhood, closely linked to social skill development, mental well-being, and long-term academic success. Throughout this paper, researcher Lydia Caldwell explores the following question: what approaches can a preschool teacher use to support their students’ emotional regulation skills? Drawing from both literature and personal classroom experiences, this project was created with the author’s profession in mind. As a special educator who works with preschool students, Caldwell sees firsthand the amount of children struggling with emotional regulation, also referred to as self-regulation. The project will result in a series of flyers which serve as …


The Influence Of Supported Mainstream Classes On High School Special Education Students' Social And Emotional Learning, Clare Murr Jul 2025

The Influence Of Supported Mainstream Classes On High School Special Education Students' Social And Emotional Learning, Clare Murr

School of Education and Leadership Student Capstone Projects

This study investigated how participation in supported mainstream classes influences social and emotional learning outcomes of high school special education students. The project was a result of the research done to answer the question: When high school special education students participate in supported mainstream classes, how are their social and emotional learning outcomes influenced? A comprehensive literature review revealed that integration of special education students into the mainstream classroom benefits their social and emotional development; however, unsupported inclusion often results in isolation and peer rejection. Effective co-teaching partnerships, that use the combined expertise of general and special education teachers, can …


Using Fables To Enhance Social Emotional Learning, Eric Albers Jul 2025

Using Fables To Enhance Social Emotional Learning, Eric Albers

School of Education and Leadership Student Capstone Projects

The research question guiding this project is: How can we use fables to strengthen SEL connections with our students and families while enhancing the relationship between character development and life skills? The project addresses growing concerns about student anxiety, depression, and social disconnection while recognizing schools' expanding role in mental health. This work builds upon literature on home-school partnerships, bibliotherapy, and culturally responsive pedagogy, including research on fable comprehension, CASEL's SEL framework, and "funds of knowledge" that honor diverse cultural perspectives.The methodology involved developing a curriculum unit that integrates fables into the existing CharacterStrong SEL program through a Universal Design …


Solid Waste Education For Fourth Grade Students In Washington County, Minnesota, Jessica Hall Jul 2025

Solid Waste Education For Fourth Grade Students In Washington County, Minnesota, Jessica Hall

School of Education and Leadership Student Capstone Projects

The topic of environmental education has grown in recent years, but this study discovered that there is a lack of education focused on solid waste. Four key themes were explored in the current literature: climate anxiety, place-based education, social-emotional learning, and behavior change. This paper is not a research study, but rather a summary of previous research with a discussion of the current situation supporting the need for, and process of, this project’s development. The guiding questions for developing this project are: How can 4th-grade students and teachers in Washington County, Minnesota, perceive the impact of solid waste education lessons …


Promoting Environmental Literacy And Stewardship Through Interdisciplinary Teaching, Eric Wadnal Jul 2025

Promoting Environmental Literacy And Stewardship Through Interdisciplinary Teaching, Eric Wadnal

School of Education and Leadership Student Capstone Projects

Some of the most pressing issues the current generation is experiencing are related to the environment. Teachers, regardless of discipline, must be prepared to equip students with the knowledge, skills, and attitudes required to solve these issues. Environmental education (EE) is critical for promoting environmental literacy and stewardship. Therefore, this paper explores the research question: How can environmental education be applied to interdisciplinary learning that emphasizes community and builds meaningful connections to the local environment? The impact of connecting students to local environments and communities demonstrates the need for EE approaches that are contextually relevant, participatory, and interdisciplinary. To support …


Fostering Resilience Through Near Peer Mentorship In Elementary School, Bway Paw Jul 2025

Fostering Resilience Through Near Peer Mentorship In Elementary School, Bway Paw

School of Education and Leadership Student Capstone Projects

Near-peer mentoring involves pairing students with peers who are close in age but slightly more advanced in experience ensures the students' needs are met in ways that feel supportive and accessible. This capstone project explores how peer mentoring fosters social-emotional resilience in elementary students. The project is designed for a ten-week curriculum using the Minnesota SEL standard, which uses CASEL’s five competencies to be integrated into the classroom. Frameworks that carry this project include Bandura's social learning theory and self-efficacy, Vygotsky's Zone of Proximal Development (ZPD), Identity-Based Motivation (IBM), along with Masten’s ordinary magic. Research on resilience highlights that resilience …


Beyond Language Barriers: Challenging The Equity And Validity Of English-Only Standardized Tests For English Language Learners, Courtney Pille Jul 2025

Beyond Language Barriers: Challenging The Equity And Validity Of English-Only Standardized Tests For English Language Learners, Courtney Pille

School of Education and Leadership Student Capstone Projects

English Language Learners represent one of the fastest-growing student populations in American schools, yet they are required to take state standardized tests designed exclusively for native English speakers. This practice creates significant validity, reliability, and equity concerns–as research demonstrates that academic English proficiency takes 4-8 years to develop while students face annual testing requirements beginning in grade 3. This capstone uses a comprehensive literature review examining standardized testing practices, English language acquisition processes, and equity challenges to answer the research question: To what extent does administering English-only standardized tests to English Language Learners (ELLs) produce valid measurements of their academic …


Form A More Perfect Union: Educational Direction For Teaching Effective Political Discourse, Brian Merchant Jul 2025

Form A More Perfect Union: Educational Direction For Teaching Effective Political Discourse, Brian Merchant

School of Education and Leadership Student Capstone Projects

Efforts to strengthen civics education in support of democracy have expanded in recent years. Schools increasingly offer project-based learning, authentic assessments, and rigorous course options. Yet while standards emphasize argument formation, little attention is given to the practical skills required for political discussion. Research shows that public schools, with their diversity of perspectives, are well suited to foster dialogical approaches to civic discourse. Despite this potential, classroom discussions often lack depth, and educators frequently lack the resources and training to engage students in high-quality political dialogue. This literature review identifies the importance of political discourse education, interdisciplinary practices to improve …


The Integration Of Movement And Technology In Elementary Schools: Enhancing Student Learning, Emily Hillis Jul 2025

The Integration Of Movement And Technology In Elementary Schools: Enhancing Student Learning, Emily Hillis

School of Education and Leadership Student Capstone Projects

Following the COVID-19 pandemic, the use of technology has increased within elementary classrooms. Research shows that there are many advantages and disadvantages to students having these technology tools during the school day. Movement-based learning has since taken a decline in elementary classrooms since the pandemic. Research suggests that movement is impactful to students retention, engagement, and mood. This encouraged the idea of How can educators combine technology and movement activities to enhance learning outcomes for elementary students? The literature review explores the different sides of technology and movement-based learning. It examines the advantages and disadvantages, challenges, and the impact that …


Infusing Dakota Values And Indigenous Pedagogies Into Secondary Social Studies Curriculum, Lily Fox Jul 2025

Infusing Dakota Values And Indigenous Pedagogies Into Secondary Social Studies Curriculum, Lily Fox

School of Education and Leadership Student Capstone Projects

This project was very meaningful for me both professionally and personally. There was a lot of growth as a researcher, teacher, and person; this growth is reflected in the project as well. I chose Dakota values to be regionally conscious of students that may be in the classroom and their cultures. The project itself shows how Indigenous pedagogies can be applied to content that may not appear to be Indigenous-related. The unit covers the emergence of trade on a global scale (700-1500CE) in a ninth grade world history classroom. Using Understanding by Design’s backward planning model as well as a …


Assessing The Relationship Between Screen Time, Academic Achievement, Executive Function, And Emotional Regulation: The Role Of Digital Citizenship In The Upper Elementary Classroom, Katherine Carlson Jul 2025

Assessing The Relationship Between Screen Time, Academic Achievement, Executive Function, And Emotional Regulation: The Role Of Digital Citizenship In The Upper Elementary Classroom, Katherine Carlson

School of Education and Leadership Student Capstone Projects

Recent research has shown that elementary school students are spending time online at unprecedented rates, and that this excessive screen time has negative impacts on the physical and psychological health of children. The research question addressed in this project was: what is the association between screen time, academic achievement, executive function, and emotional regulation in elementary school-aged children? Excessive screen time has been found to negatively impact children’s emotional regulation, but the data regarding the association between academic achievement, executive function, and screen time were inconclusive, resulting in a partial rejection of the hypothesis. The research suggested that screen time …


Centering Adult Basic Education Students As Learners And Creators With Class Websites, Kristy Cannon Jul 2025

Centering Adult Basic Education Students As Learners And Creators With Class Websites, Kristy Cannon

School of Education and Leadership Student Capstone Projects

An adult basic education (ABE) class website can integrate educational theories and technology to center students as learners and creators. This research explored educational theories that include andragogy, other adult-specific learning theories, heutagogy, constructivism, culturally relevant theories, and traditional teacher-centered learning models and methods. This project integrated those learning theories with the online modality of a tool-rich class website to promote digital literacy and center students as learners and creators actively participating in their own learning. The project is a Google Sites class website that can be used as a model or template for ABE teachers to copy, modify, and …


What Are The Most Effective Social-Emotional Behavioral Management Strategies For Creating A Culturally Affirming Classroom Environment?, Bill Cook Jul 2025

What Are The Most Effective Social-Emotional Behavioral Management Strategies For Creating A Culturally Affirming Classroom Environment?, Bill Cook

School of Education and Leadership Student Capstone Projects

Classroom management often emphasizes teacher control and a top-down approach. But what if we built a classroom culture with students, one rooted in relationships, identity, culture, and the social-emotional skills they need to succeed? This Capstone explores how integrating SEL into academic and classroom settings can shape classroom culture and transform our approach to management. It answers the question, What are the most effective social-emotional behavioral management strategies for creating a culturally affirming classroom environment? How can creating a binder of social-emotional strategies help teachers create a culturally affirming classroom? This project highlights the five core SEL competencies—self-awareness, self-management, social …


How Does The Use Of Restorative Circles During Instruction Impact Student Engagement And Agency?, Sydney Smith Jul 2025

How Does The Use Of Restorative Circles During Instruction Impact Student Engagement And Agency?, Sydney Smith

School of Education and Leadership Student Capstone Projects

The purpose of my capstone project was to explore and help answer the research question of How does the use of Restorative Circles during instruction impact student engagement and agency? Through a Literature Review, professional experiences, and personal beliefs around teaching, this capstone project is inspired by Restorative Practices, specifically Restorative Circles, and how they build community in the classroom. The project helps educators in creating a classroom community that limits disruptive behaviors which is supported by personal educator experience, along with scholarly studies that found student engagement is impacted by personal relationships with their teacher and peers. When students …


The Literary Games We Play: Science Fiction In The Teaching Of Secondary Science, Luiza Roos Jul 2025

The Literary Games We Play: Science Fiction In The Teaching Of Secondary Science, Luiza Roos

School of Education and Leadership Student Capstone Projects

This project responds to a need for interdisciplinary approaches that merge literacy development with scientific inquiry, recognizing the challenges of engaging diverse learners in complex ecological and evolutionary content. Drawing from research in fiction-based learning (Wong et al., 2024), science fiction and science pedagogy (Bixler, 2007), role-playing games in education (Cheville, 2016), and culturally responsive teaching (Rodriguez & Morrison, 2019), the project aims to make science more accessible, inclusive, and relevant to students’ lived experiences. This capstone explores how science fiction novels, specifically The Kaiju Preservation Society by John Scalzi, can be effectively integrated into a secondary science curriculum to …


Dying In The Light Of Eternity, Daniel Rubio Jul 2025

Dying In The Light Of Eternity, Daniel Rubio

Faith and Philosophy: Journal of the Society of Christian Philosophers

No abstract provided.


Evaluation Of Internally Cooled Radiofrequency Ablation Targeting Multiple Shoulder Nerves For Chronic Shoulder Pain Relief And Function Restoration: A Prospective Study, Mitsukuni Yoshida, Peter K Park, Loc V Thang Jul 2025

Evaluation Of Internally Cooled Radiofrequency Ablation Targeting Multiple Shoulder Nerves For Chronic Shoulder Pain Relief And Function Restoration: A Prospective Study, Mitsukuni Yoshida, Peter K Park, Loc V Thang

2020-Current year OA Pubs

OBJECTIVE: Shoulder pain is a prevalent musculoskeletal disorder, affecting up to 70% of adults over their lifetimes. Recently, radiofrequency ablation (RFA) has gained attention as a treatment for joint pain. This study aims to evaluate the efficacy of internally cooled RFA (icRFA) in alleviating shoulder pain and improving both qualitative and quantitative measures of shoulder function.

DESIGN: Prospective cohort study.

SUBJECTS: Patients with chronic shoulder pain (n = 35) who responded positively to diagnostic blocks of the suprascapular nerve (SSN), axillary nerve (AN), and lateral pectoral nerve (LPN).

METHODS: Patients underwent icRFA targeting the SSN, AN, and LPN. Treatment response …


Increasing Birth-Dose Hepatitis B Vaccination In Nigeria: Qualitative Analysis Of Data From A Crowdsourcing Open Call, Sonam J Shah, Maria Afadapa, Nkiruka Obodoechina, Olufunto A Olusanya, Temitope Ojo, Dawit Alemu, Juliet Iwelunmor, Et Al. Jul 2025

Increasing Birth-Dose Hepatitis B Vaccination In Nigeria: Qualitative Analysis Of Data From A Crowdsourcing Open Call, Sonam J Shah, Maria Afadapa, Nkiruka Obodoechina, Olufunto A Olusanya, Temitope Ojo, Dawit Alemu, Juliet Iwelunmor, Et Al.

2020-Current year OA Pubs

BACKGROUND: Despite World Health Organization and Nigerian recommendations for hepatitis B birth-dose (HepB-BD) vaccination, only one-third of Nigerian newborns receive timely HepB-BD vaccination, This study identified facilitators to increasing HepB-BD vaccination based on data from a crowdsourcing open call in Nigeria.

METHODS: Our team conducted an open call across Nigeria for teams to submit ideas on how to increase HepB-BD vaccination. Independent judges evaluated the submissions based on predefined criteria. We analyzed textual data from the top 29 entries using iterative coding and thematic analysis within a socioecological model to identify priority facilitators.

RESULTS: The open call received 362 total …


Covid-19-Associated Pulmonary Aspergillosis In Mechanically Ventilated Patients At 7 Us Hospitals: Epidemiology And Estimated Likelihood Of Invasive Pulmonary Aspergillosis-Results Of The Prospective Msg-017 Study, M Hong Nguyen, Sixto M Leal, Luis Ostrosky-Zeichner, Andrej Spec, George R Thompson, Thomas F Patterson, John Baddley, Rachel Mcmullen, Drashti Shah, Cornelius J Clancy, Gerald Mcgwin, Peter G Pappas Jul 2025

Covid-19-Associated Pulmonary Aspergillosis In Mechanically Ventilated Patients At 7 Us Hospitals: Epidemiology And Estimated Likelihood Of Invasive Pulmonary Aspergillosis-Results Of The Prospective Msg-017 Study, M Hong Nguyen, Sixto M Leal, Luis Ostrosky-Zeichner, Andrej Spec, George R Thompson, Thomas F Patterson, John Baddley, Rachel Mcmullen, Drashti Shah, Cornelius J Clancy, Gerald Mcgwin, Peter G Pappas

2020-Current year OA Pubs

BACKGROUND: There is no prospective, US multicenter study of COVID-19-associated pulmonary aspergillosis (CAPA). CAPA definitions do not differentiate invasive aspergillosis (IPA) from colonization. Validity of single mycologic test results is unclear.

METHODS: We performed a prospective 7-center US study of mechanically ventilated adults with COVID-19 (April 2021-May 2022). Mycoses Study Group (MSGERC) CAPA criteria include host and clinical factors, imaging and test results (histopathology; bronchoalveolar lavage [BAL] culture and/or BAL or serum galactomannan-immunoassay). Proven, putative, and unlikely IPA were defined by clinical criteria. CAPA-unlikely IPA criteria included survival or negative autopsy following no/limited antifungal treatment. IPA likelihood was estimated using …


Optimized Legionella Expression Strain For Affinity Purification Of His-Tagged Membrane Proteins Eliminates Major Multimeric Contaminant, Sukhithasri Vijayrajratnam, Jonasz B Patkowski, Joshua Khorsandi, Wandy L Beatty, Shanmugapriya Kannaiah, Ahmet Hasanovic, Tamara J O'Connor, Tiago R D Costa, Joseph P Vogel Jul 2025

Optimized Legionella Expression Strain For Affinity Purification Of His-Tagged Membrane Proteins Eliminates Major Multimeric Contaminant, Sukhithasri Vijayrajratnam, Jonasz B Patkowski, Joshua Khorsandi, Wandy L Beatty, Shanmugapriya Kannaiah, Ahmet Hasanovic, Tamara J O'Connor, Tiago R D Costa, Joseph P Vogel

2020-Current year OA Pubs

Polyhistidine tags are frequently used for isolating proteins through


Genetic Structuring And Estimation Of Reproductive Adults In Onchocerca Volvulus: A Genome-Wide Analysis Across Hosts And Regions, Pawan Kumar, Young-Jun Choi, Kerstin Fischer, Shannon M. Hedtke, Anusha Kode, Nicholas Opoku, Lincoln Gankpala, Tony O. Ukety, Jöel Lonema Mande, Timothy J. C. Anderson, Warwick N. Grant, Peter U. Fischer, Makedonka Mitreva Jul 2025

Genetic Structuring And Estimation Of Reproductive Adults In Onchocerca Volvulus: A Genome-Wide Analysis Across Hosts And Regions, Pawan Kumar, Young-Jun Choi, Kerstin Fischer, Shannon M. Hedtke, Anusha Kode, Nicholas Opoku, Lincoln Gankpala, Tony O. Ukety, Jöel Lonema Mande, Timothy J. C. Anderson, Warwick N. Grant, Peter U. Fischer, Makedonka Mitreva

2020-Current year OA Pubs

Genomic analysis of parasites can deepen our understanding of their transmission, population structure, and important biological characteristics. Onchocerciasis (river blindness), caused by the parasitic nematode Onchocerca volvulus, involves adult worms residing in subcutaneous nodules that produce larval-stage microfilariae (mf), which are routinely detected in the skin for diagnosis. Whole-genome studies of mf are limited; most analyses have focused on the mitochondrial genome. We conducted a genome-wide analysis with 94% median nuclear genome coverage, analyzing 171, 37, and 98 mf from 16, 3, and 5 individuals from Ghana, Liberia, and the Democratic Republic of Congo, respectively. These data were used to …


The Loss Of Opa1 Accelerates Intervertebral Disc Degeneration And Osteoarthritis In Aged Mice, Vedavathi Madhu, Miriam Hernandaz-Meadows, Ashley Coleman, Kimheak Sao, Kameron Inguito, Owen Haslam, Paige K Boneski, Hiromi Sesaki, Ruteja A Barve, John A Collins, Makarand V Risbud Jul 2025

The Loss Of Opa1 Accelerates Intervertebral Disc Degeneration And Osteoarthritis In Aged Mice, Vedavathi Madhu, Miriam Hernandaz-Meadows, Ashley Coleman, Kimheak Sao, Kameron Inguito, Owen Haslam, Paige K Boneski, Hiromi Sesaki, Ruteja A Barve, John A Collins, Makarand V Risbud

2020-Current year OA Pubs

Recent studies have highlighted the importance of mitochondria in NP cells and articular chondrocyte health. Since the understanding of mechanisms governing mitochondrial dynamics in these tissues is lacking, we investigated the role of OPA1, a mitochondrial fusion protein, in their homeostasis. OPA1 knockdown in NP cells altered mitochondrial size and cristae shape and increased the oxygen consumption rate. OPA1 governed the morphology of multiple organelles, including peroxisomes, early endosomes and cis-Golgi and loss resulted in the dysregulation of autophagy. Metabolic profiling and


Sexually Dimorphic Impact Of Prenatal Hyperandrogenism On Offspring Growth Trajectory In Sheep, Eylem Topaktas, Joseph Ciarelli, Stephanie Domke, Brooke Pallas, Adel Ghnenis, Mansi Agarwal, Charles Goss, Kevin Cho, Leah P Shriver, Gary J Patti, Vasantha Padmanabhan, Arpita Kalla Vyas Jul 2025

Sexually Dimorphic Impact Of Prenatal Hyperandrogenism On Offspring Growth Trajectory In Sheep, Eylem Topaktas, Joseph Ciarelli, Stephanie Domke, Brooke Pallas, Adel Ghnenis, Mansi Agarwal, Charles Goss, Kevin Cho, Leah P Shriver, Gary J Patti, Vasantha Padmanabhan, Arpita Kalla Vyas

2020-Current year OA Pubs

In a translationally relevant ovine model of gestational hyperandrogenism we have previously reported cardiometabolic disruption in female offspring (males were not extensively studied). We hypothesized that gestational hyperandrogenism would lead to sex-specific disruption in offspring's growth, cytokine and metabolic milieu, potential mediators of cardiometabolic disease (CMD). 100 mg Testosterone propionate (T) or vehicle (C) was administered intramuscularly twice weekly between gestational days (GD) 30-90. Two cohorts of offspring were generated, including both males and females. Fetal weight and systemic metabolomics were analyzed in the fetal cohort (GD120). Growth trajectory, systemic cytokines, and metabolomics were analyzed in the postnatal cohort. Data …