Digital Commons Network^™

Localization Of Alpha Power Deficits In First Episode Psychosis, Crystal A. Garcia, Juan Bustillo

Biomedical Sciences ETDs

The purpose of this study was to determine where in the brain there may be a difference in brain activity in patients during their first episode of psychosis (FEP) compared to healthy controls (HCs) while performing an auditory oddball task. Time-frequency analysis allows for spectral decomposition where the signal measured by magnetoencephalography (MEG) is used to characterize changes in neural oscillations and their synchronization over time and region. Previous EEG studies report reduced alpha (8-12Hz, 70-160ms) power but most studies focused on patients with chronic schizophrenia and with limited source localization.

Guardian Perceptions Of Living In Group Homes Versus Family Homes For Individuals With Intellectual Disabilties, Gail Roberts Williams

Walden Dissertations and Doctoral Studies

The living environment of group homes and family homes offer different qualities of life for individuals with intellectual disabilities. Guardian perceptions may shed light on how individuals with intellectual disabilities perceive their experiences, environments, and daily lives. Exploring and examining this social problem may positively impact policies, processes, and procedures, and have an impact on the lives of parents, families, and individuals with intellectual disabilities while driving positive social change. The purpose of this qualitative study using narrative inquiry was to explore, examine, and better understand guardian perceptions. The quality-of-life theoretical framework and Saldana’s process of color coding were used …

Elizabethkingia Infections - An Important Emerging Cause Of Sepsis And Meningitis In Neonates And Infants: Case Series From North Batinah Region, Oman, And Literature Review, Mohammed Said Al Reesi, Latifa Abdullah Al Muttawa, Mariam Abdullah Albolushi, Naima Salim Al Risi

Sultan Qaboos University Medical Journal

Elizabethkingia species, particularly E. anophelis and E. meningoseptica, are gram negative bacilli known to be associated with neonatal infections. Although these bacteria are rare, they are highly concerning pathogens associated with severe sepsis, bacteraemia and meningitis in neonates and immunocompromised individuals. Managing Elizabethkingia infections presents significant challenges because of their multidrug resistance, including resistance to most β-lactam agents. They have been implicated in both nosocomial and community outbreaks worldwide, often with high mortality rates. In Oman, Elizabethkingia infections are underreported, with only 1 publication documenting 2 cases of E. meningoseptica bacteraemia and meningitis, both of which were successfully …

A Mutational Analysis Of Thatisin: How Single Point Mutations Impact The Biosynthetic Process Of A Group 16 Graspetide, John F. Boynton Jr

Chemistry and Chemical Biology ETDs

Abstract:

Graspetides are a family of Ribosomally synthesized and Post-translationally modified Peptide (RiPP) natural products named for their ATP Grasp Macrocyclases. We identified several Graspetide Biosynthetic Gene Clusters containing common double glycine cleavage motifs and attempted characterization of the mature Graspetides. One of the resulting peptides, Thatisin, has a topology with two interlocking macrolactones installed by a single ATP Grasp Ligase named ThtC. Here we use single and double point mutations to observe the impact or variation on the installation of these macrocycles. Alanine scan mutagenesis is used to assess leader peptide residues in the precursor peptide ThtA to determine …

Finite Element Investigation Of Blast Load Responses In Nuclear Power Plant Containment Structures, Janak Raj Awasthi

Civil Engineering ETDs

Some significant incidents like the Chernobyl disaster (1986), the Fukushima Daiichi hydrogen explosion (2011), and some frequent military and terror threats to the nuclear Power plant structures have led to studying the capacity of power plant structures to withstand blast loadings. From this research, even one-third of the loss of the coolant is enough to damage the power plant structure. Crack starts from the wall and propagates toward the top of the dome and the foundation. The external blast shows high damage symptoms near the foundation area. Most of the steel members, including the rebars, Liner, and Tendons, showed high …

Understanding The Metallic And Oxide Phases In Platinum-Based Bimetallic Heterogeneous Catalysts After High-Temperature Oxidation, Stephen John Porter Jr

Nanoscience and Microsystems ETDs

Platinum (Pt) and palladium (Pd) are critical components in diesel emission control systems, enabling the conversion of harmful pollutants under demanding conditions. However, Pt’s effectiveness is hindered by sintering under high-temperature oxidizing environments. This dissertation investigates how Pt and Pd evolve under oxidizing conditions at 800°C, highlighting their distinct thermodynamic behaviors and interactions. Using TEM, EDS, EELS, XRF, XRD, and EXAFS, we show that Pd suppresses Pt sintering by reducing the volatility of PtO₂, leading to the formation of stable particles. Both Pt and Pd are present in metallic and oxide states, forming biphasic 'Janus' particles with conjoined metal and …

Advancements In Microarray Manufacturing Enable Emerging Technologies, Kendall Hoff

Biomedical Engineering ETDs

Significant advances in manufacturing technologies have enabled the production of new DNA microarrays for use in emergent technology. Photolithography, wafer scale manufacturing, and improvements in synthesis chemistry and design enable high-throughput production of extremely high-quality arrays. These new arrays offer extremely high oligonucleotide densities, in the range of tens of thousands of oligonucleotides per square micron. They also offer smaller features sizes, with millions of features per square centimeter. Furthermore, they can be manufactured with the DNA tethered at either end to the surface, leaving either the 5’ or 3’ end free and available for use in enzymatic reactions; and …

Gallic, Aconitic, And Crocetin Acids As Potential Tnf Modulators: An Integrated Study Combining Molecular Docking, Dynamics Simulations, Admet Profiling, And Gene Expression Analysis, Adolat Manakbayeva, Ahdrey P. Bogoyavlenskiy, Timur Kerimov, Igor Yershov, Pavel Alexyuk, Madina Alexyuk, Vladimir Berezin, Vyacheslav Dushenkov

Publications and Research

Organic acids, as natural metabolites, play crucial roles in human metabolism and health. Tumor Necrosis Factor (TNF), a pivotal mediator in immune regulation and inflammation, is a key therapeutic target. We evaluated ten organic acids as TNF modulators using in silico molecular docking, followed by detailed ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) profiling and molecular dynamics (MD) simulations for three lead candidates: gallic, aconitic, and crocetin acids. Their effects on TNF gene expression were then assessed in vivo using a mouse leukocyte model. The in silico results indicated that crocetin had the highest TNF binding affinity (−5.6 to −4.6 …

Rethinking The Applicability Of Section 8 Of The Canadian Charter For The Information Age And Beyond, François Tanguay-Renaud

All Papers

The Supreme Court of Canada’s interpretation of the right to be secure against unreasonable search and seizure guaranteed by section 8 of the Canadian Charter of Rights and Freedoms has remained fairly stable since the adoption of the Charter. Or at least, that is how the Court’s section 8 jurisprudence to date makes it seem. Yet, in some recent decisions dealing with digital communications and the internet—culminating in the 2024 case of R. v. Bykovets—the Court has, implicitly, brought into question the foundational principle based on which the right has historically been circumscribed. Or so I argue in …

Assessing The Effects Of Antibiotic Selectivity And Temperature On The Antimicrobial Activity Of Isolates Derived From The Deep-Sea Sponge Pheronema Capenteri, Lex L. Hilario

The Plymouth Student Scientist

The rapid increase of antibiotic resistance necessitates the discovery of novel antibiotic compounds capable to tackle these resistant bacteria. Deep-sea sponges accommodate a diverse and dense microbiome filled with an array of bacterial communities that have the potential to produce novel antimicrobials. Some discovered novel strains have already shown their capability in producing secondary metabolites that are effective against clinically relevant strains. This study aims to evaluate the impacts of different culture conditions; antibiotic selectivity and temperature, on the antimicrobial activity of isolates recovered from three different Pheronema carpenteri deep-sea sponges. Using culture-dependant methods, a total of 59 bacterial isolates …

Comparing P62 And Lc3 As Autophagy Biomarkers: Insights Into Cellular Homeostasis, Riya Roychan

The Plymouth Student Scientist

Autophagy is a fundamental cellular process that maintains homeostasis by the degradation of damaged organelles and proteins. It plays crucial roles in cellular remodelling, development, and disease progression. These roles apply to the study of neurodegenerative diseases which is heavily linked to the toxicity produced by unwarranted accumulation of cellular material. A key player in autophagy is LC3, which translocate to autophagosomal membranes during the process. Detecting fluorescently labelled LC3-II through immunofluorescence provides a valuable method for assessing autophagy levels in samples. In a similar premise p62, also known as sequestosome-1 (SQSTM-1), is an adaptor between LC3 and ubiquitinated substrates, …

Analisis Kualitas Pelayanan Customer Service Pada Rumah Sakit Di Provinsi Dki Jakarta, Badra Al Aufa

Jurnal Administrasi Bisnis Terapan

Improving the quality of hospital services could be increase profit, market share and cost savings. Staff in front desk plays an important role in affect satisfaction patients, possibility for someone to recommend service and grades create a for patients. This study attempts to analyze the quality of customer service unit at hospital in Jakarta, Indonesia. This research used observation method. Data collection technique was using ghost shopping method. Research has been conducted on 19 hospitals in Jakarta. The selection of hospital was using purposive sampling method. Check list has been used for data collection. Observation has been conducted to see …

Clinician And Caregiver Perspectives On A Community-Based Dynamic Temporal And Tactile Cueing Treatment Trial For Childhood Apraxia Of Speech: Exploring Perceptions Of Research And Routine Clinical Practice, Donna C. Thomas, Geraldine Bricker-Katz, Elizabeth Murray, Shelley L. Velleman, Jenya Iuzzini-Seigel

Speech Pathology and Audiology Faculty Research and Publications

Purpose:

Dynamic Temporal and Tactile Cueing (DTTC) is an evidence-based treatment for children with childhood apraxia of speech. In clinical practice, speech-language pathologists (SLPs) frequently use an eclectic approach incorporating aspects of DTTC, for reasons that are not well understood. This research note describes a qualitative investigation of the experiences of SLPs and caregivers who participated in protocolized research DTTC for a 24-session treatment efficacy study. Specifically, we sought to understand the perspectives of these SLPs and caregivers regarding (a) DTTC treatment, as provided during the study, and (b) participating in a treatment research study.

Method:

Four SLPs and three …

Beyond The Pitch: Teaching Emotional Labor In Advertising Education Through An Action Research Program, Michael Joseph Mallory

Theses and Dissertations

As the advertising industry continues to expand, new graduates must navigate the profession in the face of increasing challenges. With competition in the job market growing and Generation Z valuing work-life balance, the advantage of quality advertising education becomes paramount. Current advertising education does not address the challenge of emotional labor that professionals will face in the field. With limited scholarship that explores emotional regulation, communication dynamics, and client relations in an academic advertising setting, emotional labor in advertising education is explored through a thoroughly documented experiential learning study. This study employs Participatory Action Research (PAR) to investigate, develop, and …

Full Issue 19.1

Genocide Studies and Prevention: An International Journal

No abstract provided.

Where Are The Criminologists?: The Persistent Absence Of The Field In Genocide Research, Grace Allbaugh, Susan A. Woollen, Jacqueline L. Schneider, Joanne Savage

Genocide Studies and Prevention: An International Journal

The rallying cry of “Never Again” was heard worldwide after the Nazis’ annihilation of Jews and other victims were discovered after WWII. The global community promised that the crime of genocide would be prevented and signatory parties of the United Nations Convention on the Prevention and Punishment of Genocide (December 9, 1948) would do everything in their power to prevent another Holocaust from occurring. Unfortunately the “crime of all crimes” remains an almost permanent fixture in international news while signatory parties remain reluctant to call the ongoing conditions genocide. The field of genocide studies is built upon an interdisciplinary field …

#Bergeraklebihbaik As A Cultural Campaign: Brand Activation, Digital Lifestyle, And Urban Health Consciousness In Contemporary Indonesia, Putri Ayu Ningtyas, Hardika Widi Satria, Besty Priyandhini, Naldo Tantuah, Muhammad Heychael, Nazira Shafera Kirana

International Review of Humanities Studies

In today's hyper-competitive branding environment, marketing strategies are no longer solely focused on product promotion but have evolved into cultural practices that shape societal norms, values, and identities. This study explores how Pristine, a premium bottled mineral water brand, utilized brand activation through the #BergerakLebihBaik campaign to not only increase brand awareness but also construct a cultural narrative around health, wellness, and lifestyle among urban Indonesian consumers. Through a mixed-method qualitative approach including social media observation, in-depth interviews, and document analysis, this research demonstrates how the campaign functioned as a cultural artifact that mediated discourses of modern health, digital engagement, …

Elevated Nr2f1 Underlies The Persistence Of Invasive Disease After Treatment Of Braf-Mutant Melanoma, Manoela Tiago, Timothy J. Purwin, Casey D. Stefanski, Renaira Oliveira Da Silva, Mitchell E. Fane, Yash Chhabra, Jelan I. Haj, Jessica L. F. Teh, Rama Kadamb, Weijia Cai, Sheera Rosenbaum, Vivian Chua, Nir Hacohen, Michael A. Davies, Jessie Villanueva, Inna Chervoneva, Ashani T. Weeraratna, Dan A. Erkes, Claudia Capparelli, Julio A. Aguirre-Ghiso, Andrew E. Aplin

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Despite the success of targeted inhibitors in cutaneous melanoma, therapeutic responses are limited by the aged tumor microenvironment and drug-tolerant residual cells. Given the similarities between drug tolerance and cellular dormancy, we studied the dormancy marker, nuclear receptor subfamily 2 group F member 1 (NR2F1), in response to BRAF-V600E inhibitors (BRAFi) plus MEK inhibitors (MEKi) in BRAF-mutant melanoma models. Transcriptomic analysis of melanoma patient samples treated with BRAFi + MEKi showed increased NR2F1. NR2F1 was highly expressed in the drug-tolerant invasive cell state of minimal residual disease in patient-derived and mouse-derived xenografts on BRAFi + MEKi. NR2F1 over-expression was sufficient …

Epigenomic Diagnosis And Prognosis Of Acute Myeloid Leukemia., Francisco Marchi, Vivek M. Shastri, Richard J. Marrero, Nam H K Nguyen, Antonella Öttl, Ann-Kathrin Schade, Marieke Landwehr, Olga Krali, Jessica Nordlund, Matin Ghavami, Fernando Sckaff, Vikash K. Mansinghka, Xueyuan Cao, William Slayton, Petr Starostik, Christopher R. Cogle, Raul C. Ribeiro, Jeffrey E. Rubnitz, Jeffery Klco, Abdelrahman Elsayed, Alan S. Gamis, Timothy J. Triche, Rhonda Ries, E Anders Kolb, Richard Aplenc, Todd Alonzo, Stanley Pounds, Soheil Meshinchi, Jatinder K. Lamba

Manuscripts, Articles, Book Chapters and Other Papers

Despite the critical role of DNA methylation, clinical implementations harnessing its promise have not been described in acute myeloid leukemia. Utilizing DNA methylation from 3314 leukemia patient samples across 11 harmonized cohorts, we describe the Acute Leukemia Methylome Atlas, which includes robust models capable of accurately predicting AML subtypes. A genome-wide prognostic model as well as a targeted panel of 38 CpGs significantly predict five-year survival in our pediatric and adult test cohorts. To accelerate rapid clinical utility, we develop a specimen-to-result protocol that uses long-read nanopore sequencing and machine learning to characterize patients' whole genomes and epigenomes. Clinical validation …

Cd206+Il-4rα+ Macrophages Are Drivers Of Adverse Cardiac Remodeling In Ischemic Cardiomyopathy, Qiongxin Wang, Mohamed Ameen Ismahil, Yujie Zhu, Gregg Rokosh, Tariq Hamid, Guihua Zhou, Steven M. Pogwizd, Sumanth D. Prabhu

2020-Current year OA Pubs

BACKGROUND: The role of cardiac CD (cluster of differentiation) 206

METHODS: Adult C57BL/6 mice underwent nonreperfused myocardial infarction to induce HF. Macrophages in murine and human hearts were profiled using flow cytometry and immunostaining. In vivo myeloid-specific IL-4Rα deletion and intramyocardial macrophage adoptive transfer defined the functional effects of macrophages polarized by IL-4 (M[IL-4]). Antisense oligonucleotides were used for in vivo IL-4Rα gene silencing in mice.

RESULTS: CD206

CONCLUSIONS: Cardiac CD206

A Phase I Trial Of Evorpacept, Lenalidomide And Rituximab For Patients With B-Cell Non-Hodgkin Lymphoma, Paolo Strati, Lei Feng, Andrey Tyshevich, Darya Shavronskaya, Julia Alesse, Noel English, Elizabeth Sheehan, Nikita Syzrantsev, Alexander Nesmelov, Tony Z Zhuang, Dai Chihara, Jason R Westin, Sairah Ahmed, Luis E Fayad, Jared Henderson, Kylie Dent, Elizabeth Mcchesney, Sattva S Neelapu, Christopher R Flowers

Faculty, Staff and Student Publications

Introduction: SIRPα+ macrophages can mediate resistance to lenalidomide and rituximab (R2) in patients with B-cell non-Hodgkin lymphoma (B-NHL). Evorpacept (ALX148) is a novel CD47 blocker that abrogates interactions between lymphoma cells and SIRPα+ macrophages.

Methods: Adult patients with B-NHL who had received at least 2 prior lines of systemic therapy were included in this single arm phase I study (NCT05025800). Evorpacept was administered intravenously (IV), in a 28-day cycle, until progression, at two dose levels (DL): 30 mg/Kg on day (D) 1 and D15 (DL1), or 60 mg/Kg on day 1 (DL2); rituximab 375 mg/m2 IV was given …

Exploring Immune System Through Computational Modeling: A Comprehensive Study Of Lymph Nodes And Immune Response Scaling, Vaccine Efficacy, And Large-Scale Extreme First Passage Time, Jannatul Ferdous

Computer Science ETDs

The adaptive immune response is a complex defense mechanism that develops over time to recognize and eliminate pathogens with remarkable precision and durability. This dissertation investigates the dynamics, scaling, and efficiency of the adaptive immune response through a synthesis of computational modeling, mathematical analysis, and agent-based simulations. First, we analyze the topology of the lymphatic network and investigate the T cell search time to find the lymph node that is containing the matching dendritic cell. Second we show how the scaling of lymph node number and volume with body mass, leads to scale-invariant search times for T cells locating antigen-bearing …

Understanding Black American Pastors' Leadership Role And Interaction With Public Health During Covid-19, Stacy L. Tolbert

Walden Dissertations and Doctoral Studies

The COVID-19 pandemic tested the leadership, response, and resilience of Black American pastors and their communities. These pastors played a crucial role in supporting their communities to lessen the impact the virus had on underlying health conditions and socioeconomic hardships that were exacerbated by the pandemic. Despite their efforts, Black American pastors frequently encountered challenges helping their community. The current research sought to understand the lived experiences of Black American pastors during the pandemic and their interactions with public health institutions to secure resources for their communities through Interpretative Phenomenological Analysis (IPA). The study was guided by the research question, …

Nursing Turnover Based On Age, Race, And Gender In Community Hospitals In Michigan, Laura Lawhorn

Walden Dissertations and Doctoral Studies

Hospitals struggle to maintain nursing staff to meet patient needs for a population that requires continuous care and experiences multiple illnesses. The purpose of this quantitative study was to investigate the variations in reasons for leaving the nursing profession (dependent variable) based on age, race, and gender (independent variables) within community hospitals in Michigan. The theoretical framework for this study was the Nursing Neuman Systems Model, which posits that nursing comprises four key components: environment, individual, nursing practice, and health. A correlational research design was utilized to address the research question and analyze the relationships between the variables. The secondary …

Experiences Of Women In K–12 Educational Technology Leadership Positions, Natalie M. Johnson

Walden Dissertations and Doctoral Studies

The problem addressed in this study was the lack of women in K–12 educational technology leadership positions in the United States. The purpose of this basic qualitative study was to explore the experiences of women in K–12 educational technology leadership regarding the challenges and successes they encountered in achieving and maintaining their positions. Feminist standpoint theory formed the framework for this study. Semistructured interviews were conducted with 10 women who were active or former K–12 educational technology leaders in public schools across the country. Open and pattern coding were used to support thematic analysis. An overarching theme of gender bias …

Implementation Of A Diabetic Complication Educational Intervention For Staff At A Community-Based Clinic, Virginia K. Dennis

Walden Dissertations and Doctoral Studies

Even though there are many modalities put in place to manage diabetes and its complications, there have been many barriers to reducing the complications associated with diabetes in health care institutions. In this educational intervention to reduce diabetes and its complications, a staff education program was implemented to enhance staff knowledge about diabetes and the complications associated with it. The staff education program was implemented at a community-based clinic for a DNP-prepared nurse, three RNs, and five medical assistants (MAs) working at the clinic. A pretest and a posttest were administered to assess the impact of the educational session. The …

Secured Through Stone: The Power, Monuments, And Memory Of Thyra Danmarkarbót And The Jelling Dynasty, Jacquelyn Truitt

History ETDs

Sometime in the mid-tenth century on the Jutland peninsula of Denmark, the Viking Age Queen Thyra (d. ca. 958/9) passed away and the epithet Danmarkarbót—Denmark’s Adornment—was skillfully carved onto her memorial runestone. Yet Thyra’s story has been clouded by few and unreliable textual sources, by differing assessments of her familial background that have emerged from those sources, and by misrepresentations of the material culture relating to her. This thesis explores Thyra and her place within the Viking Age Jelling dynasty through textual and material evidence and considers how the construction of both medieval and modern memory work and memorialization …

Escape The Stroke: A Game Changing Approach To Nurse Education, Lindsay Barrett, Peter Chae

Nursing

The purpose of this quality improvement project was to reinforce nursing knowledge of the stroke team activation process in a Primary Plus Stroke Center. An educational curriculum, incorporating a 45-minute interactive escape room followed by a 45-minute didactic presentation, was developed and piloted with registered nurses (N= 14) on a Progressive Care Unit in a Primary Plus Stroke Center. Participants included registered nurses with varying levels of nursing experience, from newly licensed clinicians (<6 months) to certified progressive care nurses (>2 years), all of whom completed a survey before and after completing the activity that assessed their knowledge and confidence level related to the stroke team …

Idehen V. Stoute-Phillip

All Decisions

An attorney for the landlord was sanctioned for submitting motion papers that cited numerous non-existent cases, which were determined to be the result of using an AI-based research tool without proper verification. The court found this to be frivolous conduct under 22 NYCRR § 130-1.1, warranting a $1, 000 sanction and a referral to the State of New York Grievance Committee. This decision highlights the legal risks and ethical obligations associated with using artificial intelligence for legal research, emphasizing the duty of an attorney to verify all citations and factual statements. The attorney's subsequent filing of a 94-page document with …

Cd45 And Cd148 Are Critically Involved In Neutrophil Recruitment And Function During Inflammatory Arthritis In Mice, Jan-Niklas Heming, Andreas Margraf, Karolina Najder, Giulia Germena, Mathis Richter, Anika Cappenberg, Katharina Henke, Bernadette Bardel, Lena Schemmelmann, Marina Oguama, Pia Lindental, Wida Amini, Jacqueline Sobocik, Georg Schett, Gerhard Krönke, Helena Block, Jan Rossaint, Oliver Soehnlein, Alexander Zarbock

Faculty, Staff and Student Publications

Neutrophils play a key role in autoimmune diseases like rheumatoid arthritis, contributing to tissue damage through rapid recruitment and activation. In this study, we investigated the regulatory properties of two receptor-like tyrosine phosphatases (RPTPs), CD45 and CD148, in inflammatory arthritis. Using an in vivo mouse model of K/BxN serum transfer-induced arthritis, we found that CD45 and CD148 feature distinct regulatory properties during inflammatory arthritis. CD45 is required for neutrophil infiltration, cytokine release, and reactive oxygen species production, whereas CD148 deficiency leads to a delayed onset of arthritis but unaltered overall neutrophil infiltration and reduced ROS production. Furthermore, we could demonstrate …