Linking Chronic Kidney Disease To Incident Heart Failure And Adverse Cardiac Remodeling Through The Plasma Proteome: The Aric Study, Leo F Buckley, Pranav Dorbala, Victoria Lamberson, Brian L Claggett, Yue Ren, Morgan E Grams, Josef Coresh, Kunihiro Matsushita, Ryan T Demmer, Ruth F Dubin, Rajat Deo, Peter Ganz, Christie M Ballantyne, Ron C Hoogeveen, Bing Yu, Amil M Shah

Faculty, Staff and Student Publications

Background: Investigation of circulating plasma proteins may reveal insights into molecular pathways that contribute to the development of heart failure (HF) among people with chronic kidney disease.

Objectives: The authors aimed to identify circulating kidney function-related plasma proteins that are associated with the risk of incident HF.

Methods: The authors studied participants of the ongoing longitudinal ARIC (Atherosclerosis Risk In Communities) study. Relative plasma concentrations of 4,697 unique proteins were measured with the use of an aptamer assay (Somalogic). Each protein was tested for associations with estimated glomerular filtration rate (eGFR), log-transformed urine albumin-to-creatinine ratio (UACR), and incident HF by …

Trends In Glucagon-Like Peptide 1 Receptor Agonist Prescribing Patterns, Maria Ukhanova, Joseph S Wozny, Chau N Truong, Lopita Ghosh, Trudy M Krause

Faculty, Staff and Student Publications

Objective: Obesity affects more than 40% of US adults, increasing risks for cardiovascular disease and type 2 diabetes. Glucagon-like peptide 1 receptor agonists (GLP-1 RAs), initially indicated for diabetes, show promise in weight loss but face coverage issues, high costs, and premature prescribing from physicians. Research is needed to assess prescribing patterns, especially in patients without diabetes.

Study design: We conducted a retrospective, population-based, observational study using the Merative MarketScan Commercial Database and the Merative MarketScan Medicare Supplemental Database, which capture person-specific clinical utilization and expenditures. We analyzed GLP-1 RA prescribing rates from 2018 to 2023, comparing semaglutide with other …

Computational Frameworks To Unravel The Immune Landscape, Shan He

Dissertations and Theses (Open Access)

Recent advances in immunotherapy, including immune checkpoint blockade (ICB) and adoptive cell therapy, face challenges such as resistance and immune-related adverse events, partly due to our limited understanding of the immune signaling pathways. While high- throughput genomic data provide unprecedented resolution into these immune pathways, their full potential is limited by the lack of well-annotated, context-specific immune gene sets. To address this need, I developed a workflow to construct immune gene sets by integrating RNA- seq datasets and performing decomposition. Using this approach, I constructed 28 immune- specific gene sets from 83 bulk RNA-seq datasets and 12 Natural Killer (NK) …

Use Of The Protein Misfolding Cyclic Amplification For Food Safety And Drug Discovery, Maria R. Benavente Garcia-Huidobro

Dissertations and Theses (Open Access)

Prion diseases are fatal neurodegenerative disorders caused by the misfolding of the normal prion protein (PrP^C) into its infectious form (PrP^Sc). While the zoonotic potential of chronic wasting disease (CWD) remains uncertain, the presence of prions in food products raises public health concerns. Additionally, therapeutic strategies for prion diseases remain limited. This thesis presents a methodological exploration of the Protein Misfolding Cyclic Amplification (PMCA) technique to address these challenges in two key areas: (1) detecting CWD prions in processed meats subjected to common cooking procedures, and (2) identifying potential anti-prion compounds through a high-throughput PMCA adaptation. …

Predicting Genetic Interactions Using Functional Interaction Networks, Iulia Veronica Gheorghe

Dissertations and Theses (Open Access)

Mapping genetic interactions is central to understanding cellular systems and identifying therapeutic vulnerabilities, particularly in the context of cancer. Among these interactions, synthetic lethality, where simultaneous loss of two genes is lethal but loss of either alone is tolerated, offers a powerful framework for selectively targeting tumor-specific dependencies. In model organisms like S. cerevisiae, comprehensive double-knockout screens have revealed detailed genetic interaction maps, enabling systems-level insights into pathway structure, gene function, and cellular organization. Replicating this achievement in human cells, however, is complicated by the scale and complexity of the human genome. Recent advances in genome-wide CRISPR knockout screening have …

Structural Functional Investigation Of Hap40, Amanda M. Solbach

Dissertations and Theses (Open Access)

STRUCTURAL FUNCTIONAL INVESTIGATION OF HAP40

Amanda Marie Solbach

Dissertation Advisor: Sheng Zhang, Ph.D.

Huntington’s disease (HD) is a devastating neurodegenerative disorder caused by an expanded CAG trinucleotide repeat in the Huntingtin (HTT) gene, resulting in a mutant huntingtin (mHTT) protein with an elongated polyglutamine tract. While the genetic basis of HD is well established, the mechanisms underlying mHTT toxicity and its impact on cellular function remain incompletely understood. Recent discoveries implicate Huntingtin-associated protein 40 (HAP40) as a critical regulator of HTT stability and intracellular function. However, the physiological and pathological significance of this interaction has not been fully explored.

This …

Modeling Renal Anomalies Associated With Li-Fraumeni Patients: A Novel Role For P53 In Kidney Development, Alejandra Davilavaladez

Dissertations and Theses (Open Access)

Li-Fraumeni syndrome (LFS) is a heritable disorder caused by germline mutations in the TP53 gene that result in an increased risk of cancer. The TP53 tumor suppressor gene regulates cell division and prevents the accumulation of cells that may become cancerous. LFS patients are susceptible to various types of cancers, including osteosarcoma, soft tissue sarcoma, acute leukemia, and adrenal cortical tumors, as well as breast and brain cancer. Additionally, these patients have an increased risk of developing kidney, stomach, colon, pancreas, esophagus, lung, and gonadal germ cell cancers. Prior studies indicate that p53 is involved in kidney development. However, there …

Effects Of Sex And Aging In The Response To Global Cerebral Hypoperfusion, Alexis Mcalister

Dissertations and Theses (Open Access)

Introduction

The prevalence of dementia worldwide is projected to double by the year 2030 and triple by 2050. Vascular cognitive impairment and dementia (VCID) encompasses diseases that lead to cognitive decline and dementia due to cerebrovascular disease. VCID is the second most common form of dementia after Alzheimer’s disease, accounting for approximately 15- 40% of all dementia cases. Reductions in cerebral blood flow from intracranial and extracranial atherosclerosis increase VCID risk, even in the absence of overt clinical or imaging evidence of stroke/embolization. The pathology seen in patients with chronic cerebral hypoperfusion, such as inflammation, neuronal loss, white matter abnormalities, …

Microbial Metabolite Regulation Of Microglial Ahr Signaling In Alzheimer’S Disease, Ghalya E. Alrousan

Dissertations and Theses (Open Access)

Introduction: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-β plaque accumulation, neuroinflammation, and cognitive decline. Recent evidence suggests that systemic factors, particularly the gut microbiota and its metabolites, play a significant role in shaping brain immune responses, including microglial activation. However, the mechanisms linking gut dysbiosis to microglial dysfunction in AD are poorly understood. The aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor responsive to tryptophan metabolites, has recently gained attention as a key regulator of neuroinflammation and microglial function. I hypothesize that the loss of beneficial microbial AHR ligands, specifically indole derivatives, during aging and AD …

Autoantibody Profiling To Predict Response To The Anti-Pd-1 Therapy, Pembrolizumab, In Rare Tumors, M H Derbala, J Hajjar, B Stephen, S A Gurses, E Kwiatkowski, P Budde, H-D Zucht, M Bräutigam, A-S Lindemann, B A Abhari, M A Gouda, L Castillo, A Zarifa, J A How, E Rodriguez, J T Moyers, D S Hong, S Fu, F Meric-Bernstam, A Naing

Faculty, Staff and Student Publications

Background: Immune checkpoint inhibitors (ICIs) have limited response rates in selected patients and can cause potentially life-threatening immune-related adverse events (irAEs). This underscores the urgent need for the development of biomarkers predictive of ICI response. Pre-existing autoantibodies (AAbs) have been linked with responses to ICIs and the development of irAEs. We conducted AAb profiling to assess associations between baseline AAbs and clinical benefit (CB) in patients with rare tumors treated with anti-programmed cell death protein 1-based therapy.

Patients and methods: We conducted AAb profiling using Oncimmune's SeroTag multiplex antibody discovery technology and immune oncology array containing 1168 antigens. The study …

Racial Disparities In The Receipt Of Therapies For Cancer, Hypertension, And Diabetes, And In Mortality In A Large Population-Based Cohort Of Older Men With Prostate Cancer, Zhuoyun Li, Xianglin L Du

Faculty, Staff and Student Publications

Background: Racial disparities in treatment and mortality were widely studied among prostate cancer patients; however, few studies considered the prevalence of hypertension and diabetes and their treatment status.

Objectives: To determine whether there are racial discrepancies in the use of anti-cancer, antihypertensive, and antidiabetic drugs in a cohort of long-term survivors of prostate cancer diagnosed in 2007-2015; and to examine racial disparities in mortality after adjustments for their differences in those treatments.

Methods: We used the SEER (Surveillance, Epidemiology, and End Results)-Medicare linked database and included records for patients with prostate cancer at age 65 years or older diagnosed from …

The Effects Of A Tier 2 Intervention On The Behavior Of Elementary School Students Participating In Second Step: Enhancing A Schoolwide Social-Emotional Learning Curriculum, Charlotte Annalee Kennington

Theses and Dissertations

After reviewing the current research literature on the effects of social-emotional learning (SEL) on the behavior of elementary-age children, it was clear that there was limited research data on the effects of Tier 2 interventions designed to augment the effects of schoolwide SEL programs. Specifically, to what extent could a brief, group-delivered intervention improve the academic engagement, problem behavior, and socially appropriate comments of fifth-grade students receiving schoolwide SEL through Second Step in a traditional public school? Three fifth-grade students were recruited to participate in this study who all engaged in frequent problem behavior during Second Step lessons and throughout …

Executive Committee - Agenda, 08/01/2025, Academic Senate

Academic Senate Agendas

No abstract provided.

The Experiences Of Elite, Female Club Volleyball Players – An Interpretative Phenomenological Analysis, Chelsea Brehm

Dissertations

The purpose of this qualitative study was to investigate the lived experiences of female athletes participating in national-level club volleyball in a Midwestern U.S. state. Amid increasing sport privatization and a growing emphasis on early sport specialization, female athletes in club volleyball are navigating complex pressures tied to elite competition, college recruitment, and psychosocial well-being. Using Interpretative Phenomenological Analysis (IPA), this study sought to uncover how athletes experience and make meaning of their participation in this highly demanding sport structure.

Data collection included a demographic survey distributed to national-level athletes (n = 66) and in-depth, semistructured interviews with five female …

Chancery Court Applies Entire Fairness Standard Of Review In Assessing Actions Of Conflicted Fiduciaries Engaging In "Value-Destructive" Spac Transactions, Robert S. Reder, John Rand Dorney

Vanderbilt Law School Faculty Publications

In the Gig Cases, Vice Chancellor Will followed the line of analysis she first adopted in MultiPlan by applying traditional fiduciary principles to address conflicts inherent in the standard SPAC structure. First, the Vice Chancellor rejected application of the deferential business judgment rule in favor of the more exacting entire fairness standard, finding both a conflicted controller and a conflicted board. While maybe not outcome determinative, this standard of review places a heavy burden on fiduciary defendants that generally precludes pleading stage dismissal. Second, the Vice Chancellor closely parsed language in disclosures made to stockholders to support, at least at …

Internal Funding Newsletter, Academic Year 2024-2025, Office Of Research And Creative Activity, University Of Nebraska At Omaha

Internal Funding Newsletters

The University of Nebraska at Omaha is committed to educating people of the world and the Office of Research and Creative Activity is proud to contribute to UNO?s exceptional education, groundbreaking research, and the life-long success of students and alumni. UNO innovates for the public good through pragmatic and impactful research and discovery. This year's programs provided over $750,000 in awards for students and faculty. These projects included recording a new album of music for a saxophone, flute, and piano trio, understanding college campus bicycle theft, studying student perceptions of the difficulty of organic chemistry concepts, evaluating a therapy program …

Burning The Wick At Both Ends: A Three Paper Investigation Of Burnout And Educators, Karla P. Miner

All Dissertations

Researchers in the late 20th century identified the impact of burnout on organizational and individual success. The urgency to address burnout in education has intensified following the disruptions caused by the COVID-19 pandemic. Teacher burnout, characterized by exhaustion, cynicism, and feelings of inadequacy, has been a commonly discussed topic among educators internationally following the COVID-19 pandemic. Recent studies highlight the alarming rates of burnout among educators, emphasizing the need for targeted interventions to support well-being and mitigate educator attrition. This collection of papers addresses three primary aspects of burnout and practice: a literature review of individual and organizational practice, a …

Revolutionizing Digital Privacy Education For Older Adults: Enhanced Interventions And Ai-Assisted Learning Strategies, Heba Aly

All Dissertations

As older adults increasingly engage with digital platforms, they face unique privacy risks stemming from limited digital literacy, reduced trust in AI technologies, and constrained access—especially in rural or underserved communities. While digital tools offer benefits like social connection and information access, current privacy education efforts often neglect the needs of older adults. This dissertation addresses this gap by developing, testing, and refining digital privacy education interventions tailored for older adults, with a focus on trust, personalization, and AI-assisted learning.

Study 1 evaluates multiple instructional modalities across age groups, revealing older adults prefer structured videos and interactive tutorials, while younger …

Engaging Minds: Assessing The Impact Of Arts-Integration On Science Achievement And Engagement Using Planned Experimentation, Fonda G. Dupre

All Dissertations

Elementary science education is essential for fostering inquiry, critical thinking, and problem-solving, yet it is often reduced or deprioritized due to the pressures of high-stakes testing in reading and mathematics. Despite federal calls for a well-rounded education under the Every Student Succeeds Act (2015), instructional time for science remains limited in many schools, particularly in under-resourced and high-poverty contexts. This reduction of science instruction time exacerbates achievement gaps and limits student engagement and interest in STEM fields.

This planned experiment investigates whether Arts-Integrated science instruction can increase student engagement and improve academic achievement among fourth-grade students at Foothills Academy of …

More Than Numbers: Interrogating The Instructional Capacity Of Middle School Mathematics Teachers, Yashica R. Latimer

All Dissertations

This study examines how middle school mathematics teachers conceptualize and enact culturally responsive mathematics teaching (CRMT) within a district-supported professional learning initiative. Guided by the CRMT framework developed by Aguirre and Zavala (2013), the research explores how instructional decision-making intersects with equity-focused pedagogy.

Two central questions inform the study: (1) How do middle school mathematics teachers interpret and apply CRMT principles in their classroom practice? (2) What specific instructional strategies do teachers use to integrate cultural responsiveness into their instruction?

Using a qualitative multiple-case study design, data were collected from three teachers participating in a professional learning group called MORE …

Increasing Student Enrollment In The Dual-Language Mandarin Immersion Program: Leveraging Marketing And Outreach Within A Strategic Enrollment Management Framework, Na Zhang

All Dissertations

This study examines the impact of marketing and outreach strategies on enhancing family awareness and increasing enrollment in a Dual-Language Mandarin Immersion (DLMI) program in South Carolina. The history of bilingual education has shown an increased interest in recent decades. At the same time, Mandarin immersion programs continue to face challenges and under-enrollment. This study employs a mixed-methods design to collect data from surveys and interviews with parents of children entering kindergarten. The data collection also includes interviews with Mandarin Immersion teachers and attending community events. The purpose is to identify effective practices and ongoing barriers to enrollment. Informed by …

Transforming Childhood Adversity Into Executive Excellence: Impact On Firm Performance, Kimberly Byars

All Dissertations

Many successful business leaders have overcome difficult childhoods, yet little research has examined how early hardships might actually contribute to leadership effectiveness. This study investigated whether CEOs who experienced childhood adversity can transform these difficult experiences into strengths that improve their companies' performance.

The research surveyed 165 business owners across two groups: general business owners and automotive dealership owners. Participants answered questions about their childhood experiences, their ability to grow from trauma, and various psychological traits like grit, mental toughness, resilience, and growth mindset. Company performance data was also collected.

The findings challenge conventional wisdom that difficult childhoods necessarily harm …

Evaluating The Impact Of Medicaid Expansion On Non-Small Cell Lung Cancer Care And Health Disparities, Marvin Idoteyin Okon

All Dissertations

Persistent disparities in non-small cell lung cancer (NSCLC) outcomes reflect broader structural inequities shaped by race, place, and socioeconomic conditions. This dissertation examined trends in NSCLC outcomes over the past two decades and evaluated the impact of Medicaid Expansion (ME) under the Affordable Care Act on improving outcomes and reducing disparities, especially in marginalized communities.

Using nationally representative datasets, three interrelated studies were conducted. The first assessed trends in NSCLC incidence, early-stage diagnosis, and 3-year survival from 2002-2021, stratified by metropolitan status, deprivation (Social Deprivation Index), and segregation (Index of Concentration at the Extremes). While incidence declined and early-stage diagnosis …

Evaluating Covid-19, Influenza, And Rsv Vaccine Effectiveness, Iromi N. Jayawardena

All Dissertations

Respiratory infectious diseases, including COVID-19, influenza, and RSV, pose significant public health challenges, especially during the respiratory virus season. Vaccination remains the primary intervention to mitigate morbidity and mortality associated with these diseases. Vaccine effectiveness (VE) can vary between seasons and populations, necessitating continuous evaluation. This study aims to evaluate the effectiveness of the 2024-2025 COVID-19 mRNA vaccine, 2024-2025 seasonal influenza vaccine, and single-dose RSV vaccine over two seasons.

Utilizing electronic health records (EHRs) from the Prisma Health healthcare system, this dissertation emulated target trials to assess the vaccine effectiveness of each vaccine. Risk set propensity matching was used to …

Culturally Relevant Pedagogy In Undergraduate General Chemistry, Destinee J. Cooper

All Dissertations

General chemistry is a foundational course for advancement in most undergraduate STEM programs, but unfortunately, many students do not continue in STEM after their experiences in their general chemistry course. Culturally relevant pedagogy (CRP) has the potential to increase students’ positive experiences in general chemistry by centering their needs, identities, and backgrounds. However, this pedagogical approach has not been widely studied in the college general chemistry context. As such, my four-paper dissertation broadly aimed to explore both the implementation and outcomes of CRP in undergraduate general chemistry.

The first paper reviewed the literature on culture-based pedagogies across the full undergraduate …

Exploring Teacher Decision-Making Based On 4k Children’S Emotional Observations And Narratives: A Multiple Case Study, Keith Johnston

All Dissertations

The benefits of quality social-emotional instruction in early childhood programs are well established. The crux of delivering these benefits lies in teacher social-emotional decision-making in early childhood classrooms. While there is scant research on the topic, there is evidence that decentralizing social-emotional decision-making can help teachers achieve better outcomes by including families and other early childhood professionals, using data to inform decisions, and reviewing research. The current study is a multi-case qualitative analysis of two 4K teachers from a child development center in the South Carolina Upstate. It describes how the two subjects use social-emotional decision-making to support their students’ …

Black Women Policymakers And Black Feminist Approaches In United States Gender-Based Violence Policies: Analyzing Policy Making, Institutional, And Social Media Discourse Through The Narrative Policy Framework, Gugu Selela

All Dissertations

This research study examines how gender-based violence (GBV) policy in the United States marginalizes Black women through race-neutral language and punitive frameworks. Despite facing disproportionate violence, Black women are often excluded from policy narratives, debates, and institutional priorities. Grounded in Black Feminist Thought and the Narrative Policy Framework, this study investigates how exclusion operates across legislative, digital, and institutional domains, and how Black women in public service resist and reshape GBV policy through care-centered, survivor-informed practices. Focusing on the U.S. South, the study uses a qualitative, multi-method design. It analyzes ninety-three Senate committee transcripts from South Carolina, North Carolina, and …

Emotional Safety In Pediatrics: The Impact Of Child Life Services On Healthcare Professionals’ Perceptions Of Their Own, Patients’, And Families’ Outpatient Experiences, Jenni Davis

All Dissertations

Medical visits, regardless of setting, are stressful for children and their families. Care that focuses on the emotional safety of children and families can help reduce this stress. However, not all staff feel prepared to provide emotionally safe care. Child life specialists (CLSs) are specifically trained to support emotional needs during healthcare encounters. Their presence may help staff stress as well, not just stress for children and families.

This study used three surveys to understand stress among healthcare staff working in pediatric outpatient clinics and surgery settings, and how support from a CLS affects staff, children, and families. All staff …

Teacher Efficacy In Reading Intervention: The Role Of Coaching And Professional Development In Foundational Literacy, Susan S. Chapman

All Dissertations

This Dissertation in Practice utilized improvement science methods to increase teacher self-efficacy in foundational reading practices and to address the oral reading fluency (ORF) challenges of elementary students who consistently score below proficiency. Rooted in Bandura’s theory of self-efficacy and the Active View of Reading, the study aimed to build teacher confidence in delivering foundational reading instruction while improving student ORF rates. A Plan-Do-Study-Act (PDSA) cycle was implemented with second-grade teachers and targeted the following aim: increase ORF by 12 words correct per minute (wcpm) for students receiving Tier 3 intervention over an eight-week cycle. Coaching, using the student-centered coaching …

Exploring The Socio-Cultural Dynamics Of Nocturnal Urban Landscapes: A Case Study, Jie Kong

All Dissertations

This dissertation explores nighttime social leisure activities in public parks within urban working- and middle-class communities. As cities confront climate change, shifting work schedules, and post-pandemic lifestyles, neighborhood parks have gained renewed importance after dark, especially in areas where households have limited private space. These non-commercial nighttime uses are often overlooked in planning, design, and built environment studies, yet they play a vital role in fostering cultural identity, social connection, and community well-being.

Focusing on Williamsburg and Bushwick in Brooklyn, New York, this research investigates how public parks are used at night, by whom, and for what purposes. New York …