Digital Commons Network^™

Redressing The Harm Of Accelerated Approval, Laura Karas

Articles

The accelerated approval pathway of the United States Food and Drug Administration (FDA) enables drugs to come to market more quickly than would be possible under a traditional FDA approval pathway. Accelerated approval is based upon the agency's determination that changes in a surrogate or intermediate clinical endpoint are "reasonably likely" to predict a clinical benefit meaningful for patients. In essence, the pathway affords sick patients earlier access to potentially beneficial drugs while trials to confirm clinical benefit continue. Accelerated approval has been likened to a social compromise in which promising drugs enter the market sooner in exchange for a …

Hardware And Software Design For A Portable Surgical Training Simulator, Victoria Nelson

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

More than 51 million surgeries are performed on patients annually in the United States. That number grows to 310 million surgeries performed globally each year. Most surgeons go through a minimum of five years of residency – where they train and hone their surgical skills. It is important during this time, and throughout their careers, that they get plenty of practice. Surgical training is time intensive, expensive, and frequently under-resourced. There are finite amounts of surgical training modules for students to share at their facilities. The problem of getting adequate surgical training time continues to exist after surgeons begin their …

Owl Solar-Powered Link: Duck Radio Mesh For Autonomous Monitoring, Jaden Tran, Shane Williams

Electrical Engineering

The Solar Duck Sensor Node transforms a standard DuckLink into a fully self-sustaining environmental monitor. A compact solar panel / power bank module plugs into the power ports of both the DuckLink and the Raspberry Pi Zero 2 W, keeping them charged through day-night cycles. The Pi Zero 2 W will perform local processing of sensor data. Sensor output will come from the Raspberry Pi AI Camera and its object detection capabilities. This output will be distilled into metadata and advertised over BLE. The DuckLink captures these packets, encapsulates them into LoRa payloads, and forwards them across the ClusterDuck mesh …

Hurricane Helene And Impacts On Georgia Libraries, Wilhelmina Randtke, Melissa Johnson, Kathy Davies, Erin Prentiss, Brad Warren, Emily Rogers, Emily Harris, Will Petty

Georgia Library Quarterly

In late September 2024, Hurricane Helene moved from Florida up the east coast of the United States. The hurricane struck land in the Florida panhandle, and moved north up through North Carolina. It passed over much of Georgia. The hurricane made landfall at around 11pm in Perry, Florida on Thursday, September 26. That night, it moved up through Georgia, and through to North Carolina. Governor Brian Kemp issued a state of emergency for Georgia, and later a state of emergency for 41 counties in Georgia. This article shares the experiences of librarians in Georgia in responding to and living through …

Compliance And Systems Data Management Report: Monthly Waiver Participation Trends, August 2025, Tennessee. Department Of Disability And Aging

Compliance & System Data/Reports

This monthly report provides data on various aspects of the department's activities and programs.

August 1, 2025 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Targeting Mmp-9 Activation After Early-Life Seizures Reduces Seizure Susceptibility And Memory Deficits In A Larval Zebrafish Model., Christopher Stegmuller, Alfonsina Ramón, Kasulul Melissa Bhuiyan, Nat Berk, Rebecca Han, Faisha Salami, Marina D'Angelo, Jocelyn Lippman-Bell

PCOM Scholarly Works

One in 26 Americans experience seizures, with a high incidence occurring in the first years of life. Chronic consequences of prolonged early-life seizures (ELS) in humans and rodent models vary, but can include the development of epilepsy (spontaneous, recurrent seizures) and cognitive impairment. Because it is not clear how seizures might lead to these consequences, no therapeutic strategy exists to prevent or predict them. Here, we optimized a larval zebrafish ELS model to assess a therapeutic approach targeting post-ELS sequelae. Using increased seizure susceptibility as a readout of the epileptogenic process and a novel object recognition task to assess memory, …

Evaluating What Works: A Comparison Of Five Diabetes Prevention Programs For Latino Children, Ruchi Patel

Doctor of Nursing Practice Final Project Abstract

Background: Children in the Rio Grande Valley (RGV) are at increased risk of diabetes due to limited access to effective, culturally appropriate prevention programs. Existing programs are often time-intensive, require transportation, and lack cultural relevance, reducing participation and impacting outcomes. This project aimed to evaluate diabetes prevention programs (DPPs) in the literature and identify five that may benefit children in the RGV by reducing diabetes risk.

Methodology: The Eightfold Path policy analysis approach guided this project. A literature review identified DPPs for children, and the Critical Appraisal Skills Programme (CASP) was used to assess study quality. Limitations included difficulty finding …

The Lasting Impact Of Childhood Maltreatment On Parenting: A Qualitative Study, Leslie K. Moorman

Theses, Dissertations and Culminating Projects

This qualitative study explored how Child Protection Service (CPS)-involved parents made meaning of their parenting and what informed their meaning making. Bronfenbrenner’s Person Process Context Time (PPCT) framework was utilized to examine the context of parenting within the CPS system. The PPCT theoretical assumptions were used to discuss the results of the study. Semi-structured interviews were conducted with 10 participants, from diverse ethnic backgrounds. All but one returned for a second interview. The CPS-involved parents disclosed childhood experiences that were consistent with childhood maltreatment. The participants were preoccupied with stories of their own childhood and not wanting to parent like …

Project Choices: An Experimental Serious Video Game For Performance-Based Risk Assessment, Rachel Bomysoad

Theses, Dissertations and Culminating Projects

Risk assessment for future criminal conduct currently relies on evaluator ratings or self-report measures, with imperfect predictive utility. A new serious (clinical) video game, Project Choices, was developed for assessment and treatment purposes with persons involved with the criminal legal system. Project Choices offers performance-based measurement of individuals’ responses to realistic scenarios relevant to overall criminogenic risk and individual risk factors. The current study aimed to pilot test the newest version of Project Choices (Version 2) using a sample of university students (N = 100), examining gameplay performance metrics (number of risky decisions overall and within individual risk domains) for …

Electrophysiological Markers Of Emotion Dysregulation In Autistic Youth, Rachel G. Mcdonald

Theses, Dissertations and Culminating Projects

Emotion dysregulation (ED) is a transdiagnostic mechanism that is conceptualized as difficultly regulating emotions and deploying appropriate regulation strategies in response to environmental stimuli. Meta-analyses suggest that autistic people, across the lifespan, experience more severe ED as compared to both neurotypical people and those with mental health conditions. Despite elevated risk and evidence linking ED to disruptions in neural mechanisms, no studies to date have examined neural markers of ED in autistic populations. The current project uses multi-method and multi-informant measurement to examine similarities and differences in neural mechanisms of ED in autistic and non-autistic populations. Forty-four youth aged 11—17 …

Seeing Students For Part Of Who They Are: High School Counselors' Experiences Broaching, Jessica M. Miserentino

Theses, Dissertations and Culminating Projects

Broaching is raising issues of race, ethnicity, and culture (REC) in the counseling setting. Day-Vines and colleagues (2007) introduced this skill that involves counselors bringing topics of identity into the counseling space intentionally. This phenomenological study, guided by intersectionality, aimed to explore the experiences of high school counselors broaching REC. This study provided a further understanding and definition of broaching. Five main themes emerged to describe their experiences: 1) What is Broaching? 2) Broaching Strategies, 3) Broaching with Students and Various Stakeholders, 4) Systems of Power Impact Broaching, and 5) Professional Trajectory, Training, and Counselor Identity Impact Broaching. The findings …

Mind Mentor, The Workplace Mental Health Navigator: Evaluating The Utility Of A Self-Paced Web-Based Mental Health Awareness Training For Supervisors, Lauren Offermann

Theses, Dissertations and Culminating Projects

The growing prevalence of mental health challenges in the workplace – such as anxiety and depression, burnout, suicide, and substance abuse – has increased demand for evidence-based supervisor training programs that promote psychological well-being. This study evaluated the effectiveness of Mind Mentor: The Workplace Mental Health Navigator, a 1.5-hour, web-based, self-paced adaptation of the Mental Health Awareness Training (MHAT; Dimoff, 2016) for supervisors. The training aimed to enhance mental health knowledge, awareness, self-efficacy, and supportive behaviors among U.S.-based supervisors with at least one direct report. Using a pre/post/follow-up design (baseline N = 51, immediate post-test N = 35, and 4-week …

An Examination Of The Lived Experiences Of Community College Students Of Color Who Utilize On-Campus Food Pantries, Maria Luisa Marte

Theses, Dissertations and Culminating Projects

In this dissertation, I present the findings of a descriptive phenomenological study I conducted focused on examining the experiences of community college students of color who utilize on-campus food pantries, aiming to understand how these resources impact their well-being. Through in-depth interviews, two central themes emerged. The first theme, Introduction to the On-Campus Food Pantry, highlights the accessibility of the service, with participants emphasizing the simplicity and efficiency of the registration process as a key factor in their initial engagement. The second theme, Experiences Using the Pantry, reveals that students found the pantry environment to be welcoming and non-stigmatizing, fostering …

"It's A Calling That Won't Let You Rest": The Experiences Of Counselor Educators Of Color Who Teach Social Justice, Sunanda M. Sharma

Theses, Dissertations and Culminating Projects

Social justice advocacy has been described as a foundational ethical duty for all professional counselors (American Counseling Association, 2014). Counselor educators of color (CEOCs) have advocated for the advancement of multiculturalism and social justice in counseling (Sue et al., 1992; Vera & Speight, 2003). However, their lived experiences are not well-accounted for in the counseling literature. Grounded in critical race theory (CRT) (Delgado & Stefancic, 2017), this phenomenological study sought to explore the lived experiences of CEOCs who teach students to engage in systemic social justice advocacy (SSJA). Eleven participants described the essence of their experiences and four themes emerged …

The Lived Personal History Of Queer Teachers Engaged In Queer Pedagogy, Michael C. Shera

Theses, Dissertations and Culminating Projects

This study examines a group of five queer teachers of varied ages and genders who discussed their lived experiences navigating the heteronormativity of public school structures in conjunction with their work using queer pedagogy to support students. It answers the research question: How does the lived personal history of queer educators influence how, when, and in what ways they take up queer pedagogy? Employing a life history interview methodology, along with queer theory as a theoretical framework, this study explores intersections of the participants’ life history and their engagement in queer pedagogy to examine why and how they are driven …

Comparative Expression Of Cgmp-Dependent Protein Kinase G (Pkg) From Plasmodium And Toxoplasma, Tsopmo Asaah

Theses, Dissertations and Culminating Projects

Malaria and Toxoplasmosis are life threatening diseases to humans. The search for a cure and control of these diseases is still one of the major challenges of scientists worldwide. In this research we focused on two Malaria species; Plasmodium bergei² (Pb) and Plasmodium falciparum¹ (Pf) and also on Toxoplasma gondii. Part of the life cycle of these organisms is regulated by the enzyme cyclic GMP-dependent protein kinase G (PKG)⁴. This is our drug target in this research. We believe that inhibiting this enzyme will be a great step in fighting these diseases. In this research, we devised a comparative study …

Not Just A White People's Book Club: The Participatory Action Research Of An Educator Collaborative, Jessica E. Smedley

Theses, Dissertations and Culminating Projects

This participatory action research (PAR) study investigated the learning and action of a racial and social justice book club composed of educators within a public school district. Over several years, the group engaged in collaborative cycles of inquiry, reflection, and systemic action to deepen understanding of racism, power, and equity in education. Framed by Bronfenbrenner’s Ecological Systems Theory, Relational-Cultural Theory, and Transformative Learning Theory, this study explored how learning in community supported both personal and collective transformation. Findings highlight that the book club functioned as a relational and intellectual space where vulnerability, critical reflection, and mutual accountability fostered growth-fostering relationships …

Regulation Of Icer Degradation And Its Role In Melanoma, Justin Wheelan

Theses, Dissertations and Culminating Projects

Melanoma is the deadliest form of skin cancer, with 100,640 new cases and 8,290 deaths estimated in the United States in 2024. While targeted therapies and immunotherapy have improved patient outcomes, resistance remains a major challenge, necessitating new therapeutic approaches. Approximately 50% of melanomas harbor BRAFⱽ⁶⁰⁰ᴱ mutations, leading to constitutive MAPK pathway activation. Targeted small molecule therapies such as BRAF and MEK inhibitors are available and initially reduce tumor burden, however resistance frequently occurs, likely through many pathways including compensatory activation of cAMP signaling. ICER (Inducible cAMP Early Repressor), a transcriptional repressor of CREB-mediated gene expression, is absent in melanoma …

The Cost Of Strength: Navigating Systemic Racism And The Strong Black Woman Stereotype In The Workplace, Krystle M. Davis

Theses, Dissertations and Culminating Projects

This research defined and explored the lived experiences of Black women in leadership and the role of systemic racism on the performance of the strong Black woman stereotype in the workplace. Grounded in Black feminist thought, epistemology, and phenomenology, this qualitative study seeks to deepen understanding the lived experiences of Black women. This manuscript-style dissertation comprises two studies: Study 1 consisted of nine participants who contributed through Sista Circle focus groups and Study 2 consisted of fourteen participants who engaged in semi-structured interviews to defined and examined their workplace experiences. Situated at the intersection of race and gender, this research …

08-19-25 Hsc Committee Meeting Agenda, Patricia Serna

HSC Committee (A subcommittee of the UNM Board of Regents)

08-19-25 HSC Committee Meeting Agenda

A Pilot Study Exploring Vitamin D, Mental Health, And Gastrointestinal Health In Humans, Brianna C. Williams

Master's Theses

Mental disorders are experienced by nearly one billion people worldwide. Depression is one of the most common. Treatments exist, yet a devastating 75% of individuals suffering from depression do not receive adequate treatment. An emerging treatment strategy includes exploring the connection between mental health and nutrition, which includes the areas of gut health and nutrient deficiencies. Vitamin D is obtained through food, supplements, and sunlight. Many individuals are considered deficient (25[OH]D concentrations < 12 ng/mL) or insufficient (25[OH]D concentrations < 20 ng/mL). Purpose: This study aimed to explore mental and gastrointestinal (GI) health using surveys and lipopolysaccharide binding protein (LBP) concentrations, a biomarker of GI health, in individuals considered 25(OH)D deficient (DEF) vs not deficient (N-DEF). Methods: This cross-sectional study recruited physically active participants aged 18-45 years who underwent three evaluations in one visit. Health was assessed using surveys to evaluate mental health, GI symptoms, and vitamin D intake. Serum from fasting blood samples was used with an enzyme-linked immunosorbent assay to determine 25(OH)D and LBP concentrations. Unpaired t-tests were used to compare DEF vs N-DEF and significance was set at p < 0.05. Results: Thirty-two participants (mean age 25.3 ± 6.3 years) with mean and body fat percentage of 24.0% ± 10.7%, were placed into DEF (n=16) and N-DEF (n=16) categories. Interestingly, five of the 16 participants in DEF (31%) showed some level of depression (scores ranging from mild to severe) and only two of the 16 participants in N-DEF iv (13%) scored positively in the depression category (scores ranging from mild to moderate). Additionally, the participant with the lowest 25(OH)D concentration (5.42 ng/mL) was the only participant to meet the “severe” depression category criteria, with a score of 24 compared to other participants who scored within 0-16. Also, the only participant who scored “severe” in the stress category, was in the bottom 20% of 25(OH)D concentrations. As for GI health, the difference between average GI scores and average serum LBP concentrations between the groups were not statistically significant. Conclusion: There were no significant differences between DEF and N-DEF in perceived depression (p = 0.16), anxiety (p = 1.0), stress (p = 0.96), GI symptoms (P values ranged from 0.27 to 1.00), nor in LBP concentrations (p = 0.77). Funding: Support was received from the Graduate Student Association and College of Natural Health Sciences at the University of Northern Colorado.

Effects Of Chronic Marijuana Use On Postural Control During Quiet Standing, Johnathon S. Ashcraft

Master's Theses

Marijuana, Cannabis Sativa, is the most commonly used recreational drug in the United States, with more than 60 million people reporting use in 2022 (Substance Abuse and Mental Health Services Administration, 2023). As marijuana consumption has increased, so have questions surrounding its acute and long-term effects. Its acute effects are well documented; however, the long-term effects are not as well understood. It is hypothesized that chronic marijuana users will exhibit a decrease in postural stability during quiet standing when compared to non-users, so the purpose of this study was to compare postural control of chronic marijuana users and non-users in …

Investigating The Influence Of Experimental Parameters On The Formation Of Gold Nanoparticles: A Green Synthesis And Design Of Experiments Approach, Isaac Opeyemi Subuloye

Master's Theses

This thesis examines the green synthesis of gold nanoparticles using catechin, a naturally occurring plant-derived compound, as both a reducing and capping agent. The synthesis process was guided by a structured Design of Experiments (DOE) methodology to ensure systematic investigation and optimization. A two-phase experimental approach was adopted. First, a full factorial screening design was used to evaluate the effects of catechin concentration, NaOH concentration, and pre-reaction time. This was followed by an optimization phase using a face-centered composite design to identify conditions that produce nanoparticles with ideal characteristics. The nanoparticles were analyzed using UV-visible spectroscopy and dynamic light scattering …

Cultivating Identity, Workforce Readiness, And Heutagogical Lifelong Learning: The Case For Student-Trained Ai Agents In Postsecondary Education, James Hutson

Faculty Scholarship

The accelerated integration of human-centered artificial intelligence and human-computer intelligent interaction (HCII) into postsecondary education has inaugurated a paradigm shift in how learners develop cognitive, socio emotional, and professional competencies. This article argues that requiring students to iteratively build and refine custom AI agents—digital “clones” or GPTs trained on their evolving beliefs, knowledge, values, and interests addresses three pressing challenges facing contemporary higher education. First, the process of self-modeling via agent training compels deep self-reflection, fostering socio-economic development and identity formation during the critical neurodevelopmental period that extends into the mid-twenties. Second, as industry trends increasingly prioritize the creation of …

A Word From The Writing Team (August 2025), Pam Walter, Mfa

A Word From the Writing Team (Newsletter)

This issue includes:

• Publications Spotlight
• Join the Last Summer Writing Warriors Session Tomorrow
• Check out our Fall Workshops
• Two Ways to Fund Open Access Fees

Elbow Interpositional Arthroplasty Using An Achilles Tendon Allograft: A Case Report., Matthew Glazier, Morgan Turnow, Hunter Pharis, Taylor Manes, Hayden Schuette, Stephen Wiseman

Surgery Articles

INTRODUCTION: The treatment of post-traumatic elbow arthritis poses a significant challenge for orthopedic surgeons, especially in young active patients. Total elbow arthroplasty is often the recommended treatment option in older patients; however, interpositional arthroplasty remains a viable option in high-demand patients.

CASE REPORT: We report a case of a 50-year-old male who presented after the development of post-traumatic arthritis of the elbow after multiple prior surgeries. He was treated with an interpositional arthroplasty using an Achilles tendon graft and allowed immediate range of motion as tolerated in a hinged elbow brace without the use of any form of distraction external …

White Piedra, Jane Hong, Andrew Tran, Lisa Gelles

Student Scholarship

No abstract provided.

The Scoop, Vol. 12 Issue 5, August 2025, Health Sciences Library

Volume 12

Latest news and updates from the Health Sciences Library in our monthly newsletter for August 2025. Please see page 2 for a text-only version of this issue!

Nebline, August/September 2025

NEBLINE Newsletter Archive from Nebraska Extension in Lancaster County

Contents

Summertime’s Natural Light Show: Fireflies by Kait Chapman

Insect Science with Kids: Bug Collecting as a Tool to Learn

The Perfect Partnership: EFNEP and SNAP-Ed Join Forces for Lifelong Nutrition and Health by Emily Gratopp

Recipe of the month by Emily Gratopp: Fruit salsa & cinnamon chips

Southeast nebraska Pasture & Acreage Expo

Southeast Nebraska Alfalfa & Wheat Expo

Landlord/Tenant Cash Rent workshop

Vegetable Gardening in the Fall by Mary Jane Frogge

GRO Big Red virtual learning series

2025 perennial plant of the year: Blue mountain mint (Pycnanthemum muticum)

Garden guide: Things to do this month by …