Digital Commons Network^™

Enhancing Digital Health Development Through Speech Act Theory: Application To Peripartum Depression Management, Alexandra Zingg, Tavleen Singh, Michael Truong, Sahiti Myneni

Faculty, Staff and Student Publications

The peripartum period is a time of complex transition into motherhood when women may develop peripartum depression (PPD). Digital information sources can help prevent and monitor symptoms through social support and mental health knowledge. However, few studies have characterized the content and form of peer interactions in PPD online forums to inform interventions. In this paper, we present preliminary work using a dataset of 55,301 interactions to inform our digital health development. We combine manual coding for speech acts, behavioral theory mapping, and user engagement modeling to conceptualize dynamic digital education modules for PPD. Results reveal "Expressive" speech act, where …

Towards Data-Driven Science Literacy: Extracting Psycholinguistic Markers In Vaping-Related Online Peer Interactions, Michael Truong, Ahmed Abdelhameed, Tavleen Singh, Kirk Roberts, Sahiti Myneni

Faculty, Staff and Student Publications

Social media debates on e-cigarettes raise public health concerns due to evolving evidence and conflicting guidelines. We analyzed 25,127 vaping-related comments to explore how users discuss vaping-related topics. Our analysis revealed 25 topics grouped into three parent topics: positive effects of vaping, negative effects of vaping, and vaping-related news & information. Significant differences were observed in psycholinguistic characteristics with high emotional exchanges as positive and negative effects of e-cigarettes are debated. Our results can inform interventions promoting science literacy and misinformation resistance.

Efficient Training Corpus Retrieval For Large Language Model Fine Tuning: A Case Study In Cancer., Avisha Das, Chiamaka Diala, Guocai Chen, Zhao Li, Rongbin Li, Omer Anjum, W Jim Zheng

Faculty, Staff and Student Publications

The objective is to create an automated knowledge extraction tool for cancer research that builds high-quality academic corpora for LLM fine-tuning while investigating its effectiveness in interleukin-6 and bladder cancer domains. To address the current gap in knowledge retrieval techniques for cancer research data collection, we propose KnowledgePipeline, a novel automated tool that incorporates diverse aspects of academic papers and metadata. Our tool integrates content, co-citations, and co-authorship networks to construct domain-specific academic corpora suitable for fine-tuning LLMs. We leverage two LLMs (GPTJ-6.7B and Galactica30B) trained on domain-specific question-answer pairs from the refined data. The system's evaluation focuses on both …

Frontline Acalabrutinib, Lenalidomide And Rituximab For Advanced Stage Follicular Lymphoma With High Tumor Burden: Phase Ii Trial, Paolo Strati, Lei Feng, Jason R Westin, Ranjit Nair, Luis E Fayad, Maria A Rodriguez, Dai Chihara, Luis Malpica, Jared Henderson, Mariana Gallardo, Marissa Rivera, Iris Wang, Anastasiia Bolshakova, Anastasia Radko, David Kurtz, Stefan K Alig, Christopher R Flowers, Ash A Alizadeh, Sattva S Neelapu

Faculty, Staff and Student Publications

This phase II trial aims to determine the efficacy and safety of frontline acalabrutinib, lenalidomide and rituximab for patients with advanced stage follicular lymphoma (FL) and high tumor burden. The primary endpoint was best complete response (CR) rate; the secondary endpoints were overall response rate (ORR), duration of response measured as CR at 30 months (CR30), progression of disease at 24 months (POD24) rate, progression-free survival (PFS), overall survival and safety. Twenty-four patients with previously untreated FL were included in this phase 2 single arm study (NCT04404088). The most common grade 3-4 adverse events were neutropenia (58%) and …

Histologic And Immune Characterization Of Cutaneous Immune-Related Adverse Events Induced By Immune Checkpoint Inhibitors, Omar Pacha, Anisha B Patel, Jonathan L Curry, Cara L Haymaker, Nejla Ozirmak Lermi, Dzifa Yawa Duose, Ken Chen, Joud Hajjar, Aung Naing

Faculty, Staff and Student Publications

Background: Although immune checkpoint inhibitors (ICIs) are efficacious, they often cause immune-related adverse events (irAEs), most commonly cutaneous irAEs (CirAEs). The mechanisms underlying CirAEs remain unclear.

Methods: Attempting to better understand their mechanisms and histology we conducted a prospective study of 15 patients with advanced cancers treated with ICIs who developed grade 2 or higher CirAEs. Clinical and histologic characterization of biopsy specimens of CirAEs was performed. Histologic analysis of patient biopsy specimens were subdivided by epidermal reaction patterns that included spongiotic, lichenoid, and interface dermatitis patterns. A targeted RNA expression assay was used to identify immune markers in CirAE …

Lysosomes As Gatekeepers: How Lic1-Mediated Trafficking Regulates Angiogenesis And Vascular Morphogenesis, Dymonn Johnson

Arts & Sciences Graduate Student Theses and Dissertations

Dynein cytoplasmic 1 light intermediate chain 1 (LIC1, DYNC1LI1) is a core subunit of the dynein motor complex that plays a critical role in cytoplasmic cargo trafficking, including Rab-mediated endosomal recycling and lysosomal degradation. LIC1 interacts with various cargo adaptors, such as RILPL1 and RILPL2, to regulate these processes, and defects in this gene are predicted to impair dynein motor function, Rab binding, and lysosomal trafficking. Here, we identified a dync1li1 zebrafish mutant with a premature stop codon at the exon 12/13 splice acceptor site, that exhibits increased angiogenesis. In vitro, LIC1-deficient human endothelial cells show elevated cell surface levels …

The Illusion Of “El Chingon”: A Scoping Review On How Machismo Affects Mental Health And Behavior, Vanessa Estrada Garza

McNair Summer Research Program

Machismo is a set of cultural values tethered to the gender binary, defined by the specific gender roles and expectations that men have to act upon. These ideals create a male archetype based on aggression, stoicism, superiority, and the enabling of sexist attitudes. Research has shown that rigid hypermasculine attitudes have a negative effect on mental health (e.g., depression and anxiety symptoms) and behavior (e.g., aggression and substance abuse). However, given its cultural context, much less is known about how machismo may manifest based on different demographic variables. Therefore, the goal of this scoping review was to understand the relation …

Transcription Fidelity In The Face Of Oxidative Damage, Eastilan Gyiwah Appiah

Theses and Dissertations

It is very important that the process of transcription is correctly carried out in the cell for the faithful expression of the genetic code. However, should mistakes happen, they can result in transcription errors which interfere with the protein-making machinery of the cell. This will result in accumulation of proteins and dysfunctional proteins that have the potential of causing diseases like Alzheimer’s. Oxidative damage caused by hydrogen peroxide is known to cause transcription errors in organisms like yeast. It is therefore important to investigate the extent to which hydrogen peroxide can damage cells.

Optical Trapping For The Study Of The Chemical And Physical Dynamics Of Single Particles, Yukai Ai

Theses and Dissertations

This dissertation explores the combined technique of optical trapping and Raman spectroscopy (OT-RS) to study the physical and chemical properties, as well as the dynamic surface changes, of single aerosol particles in air. The study covers a wide range of aerosol types, including bioaerosols (such as pollen, bacteria, and fungi), dust particles (such as black carbon, terrestrial, and extraterrestrial materials), and liquid droplets (such as sea-spray aerosols). The optical trapping system used in this work is based on the universal optical trap (UOT), which is capable of trapping and manipulating a wide variety of particle types. These include both transparent …

Determining The Toxic Threshold And Other Use Characteristics For Industrial Hemp Seed Oil Used For Wood Product Protection, Daylan M. Barnes

Theses and Dissertations

Plant-based wood treatments have been utilized for many years, with varying success. Oils such as those extracted from linseed (flax), tung, and hemp plants have been used for thousands of years as finishes on wood. These are all drying oils, which dry to a film when exposed to air. Hemp seed oil has a high fatty acid content and can take a long time to dry on wood products but is valued in woodworking for being easy to use, food-safe, and having little to no odor. In this study, cold-pressed hemp seed oil, blended with a soybean carrier oil, is …

Integrated Analysis Of Untargeted Liver, Serum Metabolome And Gut Microbiome Following Selenium Deficiency Diet In Selenoh Knockout And Wildtype Mice, Richard Eugene Baird

Theses and Dissertations

Selenoprotein H (SELENOH) is an oxidoreductase located in the nucleolus, and its biochemical levels decrease with selenium (Se) deficiency, as reported in mammalian research. This current investigation aimed to understand the impact of nutritional Se deficiency on gut microbial composition and metabolomic profiles. The Firmicutes/Bacteroidota (F/B) ratio, linked to various health conditions, was balanced for wildtype (WT) mice (1.06). In contrast, selenoh knockout (KO) mice associated with dietary Se deprivation had a significantly (p < 0.002) lower ratio (0.56), suggesting dysbiosis. It is believed that SELENOH levels decreased due to the Se deficient diet, and the selenoh KO mice exhibited alterations in microbial community composition and metabolite profiles, as supported by correlative analyses. With respect to the bacterial communities, significant differences between diets occurred for three taxa, including Akkemansia mucinphila, Bacteroides caecimuris, and Parabacteroides goldsteinii. Candida tropicalis, Malassezia restricta, and Cyberlindnera jadinii were three abundant fungal yeasts. Only Cyberlindnera jadinii exhibited significantly greater relative abundance between genotypes and was more abundant in the selenoh KO versus WT mice. Correlation analyses between bacterial and fungal taxa revealed both positive and negative relationships, but no specific trends were observed. The liver and serum metabolomic data contained similar amino acids, lipids, proteins, and carbohydrates. Using NMR spectroscopy, 112 liver metabolites were detected, while GC-TOF-MS analysis of the serum revealed the presence of 172, comprising both polar and nonpolar compounds. The metabolite levels varied significantly when analyzed using multivariate models such as PCA and PLS-DA (VIP scores), particularly for glucose, taurine, lactate, and UDP-glucose, which are associated with energy production and cellular health. Overall, the Se deficient diet had the most significant impact on the microbial community structure and the concentration of key metabolites within liver tissues and serum. Correlation analyses conducted across studies revealed significant linear relationships between metabolites and the microbiome. However, these differences were associated with bacterial and fungal taxa containing low relative abundances. Based on these findings, further investigation into the impact of SELENOH homeostasis on microbial and metabolite profiles should be conducted using selenoh KO mice under various nutritional Se dietary levels.

Fungal Resistance Of Citric Acid Crosslinked Chitosan Treated Wood, Samuel Jacob Barton

Theses and Dissertations

Chitosan (CH), a linear polysaccharide biopolymer derived from chitin, is known for its antimicrobial and antifungal properties. However, its natural hydrophilicity limits its application as a wood preservative. This study explores the crosslinking of chitosan with citric acid (CA) to improve its stability and hydrophobicity, aiming to enhance its efficacy as a wood preservative. The study investigates fungal resistance against Gloeophyllum trabeum (brown-rot) and Trametes versicolor (white-rot) fungi using the AWPA E-10 soil block test for pine and gum samples vacuum-treated and dip-treated with CH-CA concentrations (CH 6%/CA 3%, CH 4%/CA 3%, CH 2%/CA 3%, and CH 1.5%/CA 3%). The …

Development And Application Of A Single Nucleotide Polymorphism Panel For Individual Identification And Population Genetic Assessment Of Swamp Rabbits, Chloe S. Beall

Theses and Dissertations

Swamp rabbits (Sylvilagus aquaticus) are a potentially useful indicator species for bottomland hardwood forest ecosystem health and can be monitored using fecal pellet surveys. Advances in genetic sequencing technology have allowed researchers to obtain genetic information about wildlife using non-invasive sampling. Genotyping-in-thousands by sequencing (GT-seq) allows researchers to target specific genetic markers selected to meet their objectives, such as differentiating individuals. We investigated the utility of GT-seq for genotyping DNA derived from swamp rabbit fecal pellets. We designed a GT-seq panel for swamp rabbits, then tested the panel on fecal samples collected in the Mississippi Delta. We developed a real …

Tools We Use: Evaluating Uav And Photogrammetry Workflows For Early-Stage Site Documentation; Comparative Analysis For Small Landscape Architecture Firms, Bryant Baugus

Theses and Dissertations

Landscape architects utilize advanced technologies in the design process. Advancements in automation and data capture have opened up new opportunities for UAVs and photogrammetry to produce high-resolution imagery, contours, and 3D models. By leveraging UAVs early in the design process, landscape architects are able to maximize advantages: site analysis through computational software, 3D sectional information, and hydrology prediction. This research focuses specifically on the advantages UAVs offer compared to established workflow methods. It examines four unique workflows for early-stage site documentation: capturing the site with UAVs through photogrammetry, generating a site plan from publicly available GIS data, gathering information from …

Cotton Response To Banded Vs. Broadcast Potassium Fertilizer Rates And Varietal Response Of Peanut To Disease Pressure In A Mid-South Growing Environment, Bryce Dale Bullock

Theses and Dissertations

Cotton and peanut are commonly grown in rotation for two reasons, cotton requires high fertility, and peanuts are susceptible to diseases which cannot survive on cotton. The objectives of these two studies were to determine if banding K2O closer to the rooting zone of cotton could potentially decrease the amount of potash required to decrease costs, and to determine varietal susceptibility of peanut to early and late leaf spot and southern blight. Application rates of K2O were determined based on soil tests with a full rate being 90 Kg ha-1 and a half rate being 45 Kg ha-1 banded and …

Variables That Affect Designers’ Use Of Edible Planting In Residential Landscape Design, Emily Margaret Butler

Theses and Dissertations

Edible landscaping or “foodscaping” has had a resurgence into the mainstream. Though many trailblazers aim to encourage edible landscaping through homeowners and renters, there seems to be a lack of initiative from designers. To identify the variables that can affect a designer’s use of edible planting in the residential Southeastern United States, research and statistical methods were employed. Beyond interviewing an expert in the field of edible planting in the residential space, a survey consisting of both Likert and open-ended questions was sent to licensed landscape architects in the Southeastern U.S. The survey was conducted using Qualtrics and analyzed using …

Influence Of Diverse Forage Environments On Honey Bee Colony Health, Angus Catchot Iii

Theses and Dissertations

Honey bees are important pollinators that face a multitude of stressors in their environment such as pathogens, parasite pressure, forage availability and pesticide exposure. This study examined how the makeup of different environments and the stressors related to those environments are affecting honey bee health in Mississippi. A field experiment was conducted during the first year of the study across four distinct landscapes ranging from intensively cultivated cropland to predominantly natural forage habitats to assess the impact of landscape availability on varying honey bee colony health parameters. Locations that had cultivated crops within foraging range produced more honey and brood …

American Officer Administration Development And Its Effects On Conduct, 1900-1970, David R. Burford

Theses and Dissertations

The 1970 U.S. Army War College Study on Military Professionalism concluded that officers were so obsessed with demonstrating loyalty, deference to authority, and promotion that they seemed to sacrifice their personal integrity. The findings shocked high-ranked Army officials. The detailed legislative history of Army officer administration from roughly 1900 to 1970 presented in this dissertation shows why and how these conditions came to exist. In nine chapters, the material revealed in magazines, periodicals, student research papers, statements at congressional debates, hearings and investigations, and various official and unofficial publications narrate the development of the post-World War II American officer governance …

Characterizing The Impact Of Cover Crop On Soil Microbiome Function Affecting C And N Inputs In Corn Production System, Durga Purushotham Mahesh Chinthalapudi

Theses and Dissertations

Cover cropping (CC) is a widely adopted strategy to improve soil health and microbial diversity in agroecosystems. However, its influence on microbial community dynamics and ecosystem functions remains context-dependent, particularly under variable nitrogen (N) inputs. This dissertation integrates a three-year field study (2021-2024) in corn-based systems with a meta-analysis of 473 soil samples from diverse Mississippi cropping systems to evaluate CC effects on soil microbial structure, function, and ecosystem multifunctionality. In the field study, soil bacterial and fungal communities were profiled using high-throughput amplicon sequencing (16S rRNA for bacteria, ITS2 for fungi). Seven CC treatments ryegrass, balansa, radish, red clover, …

Soil Ethics In Practice: Harvesting Conservation Choices Among Puerto Rican Coffee Farmers, Patricia Marie Cordero-Irizarry

Theses and Dissertations

Coffee farming in Puerto Rico has declined over recent decades, partly due to deteriorating soil quality. However, the decision-making process behind farmers’ adoption of soil conservation practices remains unclear, particularly the overlooked role of soil ethics, which emphasizes the moral principles guiding human relationships with the soil. This mixed-methods study examined coffee farmers’ adoption of soil conservation practices by integrating the Values-Beliefs-Norms (VBN) theory and a newly developed Soil Ethics Survey (SES) instrument for the quantitative component, while using Decision-Making Theory and Social Cognitive Theory to qualitatively explore how farmers’ experiences and reflections shape their soil ethics. Quantitative findings revealed …

Edna Surveillance And Population Genomics Of The Invasive Loaches Introduced To The United States, Tobin J. Davidson

Theses and Dissertations

Invasive species represent a growing threat to the ecosystems and economies of the United States. The southeastern United States is an aquatic biodiversity hotspot, and the decline of multiple native species already facing extinction is attributed to a rapidly growing number of nonindigenous freshwater fishes. Next-generation sequencing was used to analyze the population genomics of several populations of Pond Loach (Misgurnus anguillicaudatus) introduced to the United States. Three evolutionarily significant units of Misgurnus loaches were found, suggesting the invasion of multiple different species in the United States. Additionally, noninvasive environmental DNA (eDNA) protocol designed for early detection of invasive freshwater …

The Evaluation Of Traditional And Latency Based Functional Analyses On The Identification Of The Function Of Inappropriate Mealtime Behavior, Mallie N. Donald

Theses and Dissertations

Research indicates that up to 80% of children with developmental disabilities have feeding problems. Feeding problems typically coexist with the presence of inappropriate mealtime behavior which includes behaviors such as aggression, throwing food or utensils, or turning head away from the presented bite. As a result, functional analysis procedures are commonly used to determine the function of inappropriate mealtime behavior to later inform effective function-based interventions. Traditional functional analysis procedures utilize the measurement of the rate of inappropriate mealtime behavior. Several limitations exist within traditional procedures for the assessment of inappropriate mealtime behavior which include demands across all test and …

Mentorship In Music Education: Crafting A Supportive Path For New Teachers, Stephen P. Fields

Theses and Dissertations

Attrition rates among new secondary music educators is an ongoing problem. Many new music educators leave the profession in their first five years with many doing so between years two and three. This project examined the difficulties faced by new secondary music educators and how involvement in a structured mentorship program can aid in their growth and development. Bandura's (1977) social learning theory and Kolb's (1984) experiential learning theory was used in the creation of the practitioner’s manual. Three research questions were addressed in this study: (1) What challenges do early career music educators face and how can a structured …

Regulating Artificial Intelligence In The U.S.: A Historical-Innovation-Inspired Framework, Di Kevin Gao

Theses and Dissertations

The emergence of OpenAI\textquotesingle s ChatGPT has marked the dawn of a new Artificial Intelligence (AI) era, unleashing a wave of user excitement, moral panic, and apocalyptic warnings. Yet, these concerns have done little to slow the breakneck pace of AI development and deployment. Should the United States adopt the European Union\textquotesingle s top-down, legislation-first approach, or follow the United Kingdom\textquotesingle s bottom-up, court-driven model? This research draws from historical legislative parallels in the U.S. By examining past regulatory frameworks for disruptive technologies, including electricity, automobiles, the telephone, broadband internet, nuclear technology, cryptocurrency, commodity futures, modern pharmaceuticals, and social media, …

Understanding How Nws Meteorologists Tailor Hazardous Weather Messaging To Core Partners And Identify Local Vulnerabilities, Allison Camille Harvey

Theses and Dissertations

Over the past few decades, the National Weather Service (NWS) has continued to improve impact-based decision support services (IDSS) efforts to strengthen communication with core partners. This study addressed how a new spatially hazard-specific vulnerability tool called the Brief Vulnerability Overview Tool (BVOT) may impact how NWS meteorologists tailor messaging to their core partners. It was found that relationship building between NWS meteorologists and core partners is key to enhancing trust, especially during blue sky days. This was done by learning core partners’ needs, thresholds, and communication styles when presenting weather information. Core partners also noticed cues from NWS meteorologists …

Tabletop Role-Playing Games As A Therapeutic Intervention: Translating Ttrpgs To Therapy, Joanne Adelle Hillerman

Theses and Dissertations

The purpose of this study was to examine the aspects of tabletop role-playing games, or TTRPGs, that are appealing to therapists, aspects of TTRPGs that may be challenging for therapists to implement, and to identify outside factors that may associated with therapists’ interest in using TTRPGs. This study used the technology acceptance model (Davis, 1989) as a theoretical framework. A sample of therapists and mental health workers (N = 102) answered survey questions on their perceptions of the ease-of-use and usefulness of TTRPGs in therapy, their likelihood to use TTRPGs in therapy, and additional items measuring outside influences on their …

Topnet R1: A Multi-Stage Ai Framework For Topic Discovery In Scientific Abstracts, Md Elias Hossain

Theses and Dissertations

Scientific abstracts are rich sources of knowledge, yet extracting meaningful topics remains challenging due to limitations in existing topic modeling techniques. Traditional methods often struggle with interpretability, scalability, and contextual understanding. To overcome these issues, we introduce TopNet R1, a multi-stage ensemble framework that integrates traditional topic models with contextual embeddings from Bidirectional Encoder Representations from Transformers (BERT) and Generative Pre-trained Transformer 4 (GPT-4) large language models (LLMs). Top- Net R1 operates in three phases: (1) topic generation using Latent Dirichlet Allocation (LDA), Non-Negative Matrix Factorization (NMF), Latent Semantic Analysis (LSA), and Hierarchical Dirichlet Process (HDP); (2) LLM-assisted pattern recognition …

Strategic Use Of Exogenous Feed Enzymes And Sodium Bisulfate To Optimize Broiler Production, Spencer Thomas Karn

Theses and Dissertations

Poultry producers must continually evaluate nutritional strategies to enhance broiler performance and sustainability. Chapter II assessed sodium bisulfate (SB) applied to litter, feed, and water across a 42-day grow-out. Applying SB to litter reduced pH, while 0.3% and 0.4% dietary SB improved feed conversion ratio (FCR). Water acidification with SB during the final week did not impair performance, supporting its use as a preharvest intervention. Chapter III evaluated phytase at 500, 1500, and 2000 FTU/kg, with or without protease, in reduced amino acid diets over 56 days. Birds fed a nutrient-adequate diet with 1500 FTU/kg phytase outperformed all reduced-amino acid …

From Gametes To Genes: Genetic Quality Assessment Of Anuran Cryopreserved Spermatozoa And Derived Embryos, Trinity Isabella Kassuhn

Theses and Dissertations

Sperm cryopreservation is an important tool within the suite of assisted reproductive technologies (ART) as it enables long-term storage of genetically valuable gametes. However, knowledge of the diagnostic criteria for assessing sperm quality and the genetic consequences of using cryopreserved sperm in amphibians is limited. This gap has raised concerns in captive breeding and reintroduction programs regarding the potential impact that cryopreserved sperm and the derived embryos may have on a population. The thesis aims to investigate how sperm cryopreservation affects the genetic material in both sperm and resulting embryos, with implications for in situ and ex situ amphibian populations. …

Documenting Children’S Use, Physical Activity, And Social Play In Tom Lee Park’S Playscape, Laurel Kelton

Theses and Dissertations

The benefits of nature and physical activity on children’s health and development are well documented. However, many children lack access to nature and physical activity. Researchers have found that “innovative playgrounds” —which, by definition, are more likely to include natural elements that facilitate nature immersion— are associated with increased physical activity and duration of stay. This thesis is a case study of a public innovative playground at Tom Lee Park. It sought to understand the playground’s areas and physical characteristics that have higher levels of use, physical activity, and social play and longer durations of stay. Data was collected over …