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Reproducibility Of Statistically Significant Phase Iii Oncology Trials: An In Silico Meta-Epidemiological Analysis, Alexander D Sherry, Pavlos Msaouel, Avital M Miller, Timothy A Lin, Joseph Abi Jaoude, Ramez Kouzy, Adina H Passy, Tomer Meirson, Nikolaos Ignatiadis, Zachary R Mccaw, Erik Van Zwet, Ethan B Ludmir Aug 2025

Reproducibility Of Statistically Significant Phase Iii Oncology Trials: An In Silico Meta-Epidemiological Analysis, Alexander D Sherry, Pavlos Msaouel, Avital M Miller, Timothy A Lin, Joseph Abi Jaoude, Ramez Kouzy, Adina H Passy, Tomer Meirson, Nikolaos Ignatiadis, Zachary R Mccaw, Erik Van Zwet, Ethan B Ludmir

Faculty, Staff and Student Publications

Purpose: The conventional assumption that P values ≤ 0.05 imply reproducible effects has come under recent criticism. This concern is particularly relevant in oncology, as phase III oncology trials, which directly inform practice, are usually not repeated. Using advanced modeling techniques, we investigated the relationship between P values and reproducibility in oncology.

Methods: We obtained the signal-to-noise ratio distribution in phase III oncology using outcomes from 632 two-arm superiority trials enrolling 496,219 patients. With this distribution, we estimated successful replication probability as the probability that a replicate trial, having the same design, effect size, and standard error, would have a …


Birth Outcomes In The Hispanic Population In The United States: Trends, Variation, And Determinants (2011–2021), Yanchao Yang, Sota Fuji '27, Thinh Nguyen '26 Aug 2025

Birth Outcomes In The Hispanic Population In The United States: Trends, Variation, And Determinants (2011–2021), Yanchao Yang, Sota Fuji '27, Thinh Nguyen '26

Business Analytics Faculty Publications

Infants born to mothers who self-identify as Hispanic account for a substantial and growing share of births in the United States, yet limited research has examined disparities in birth outcomes across Hispanic origin subgroups. This study aims to document trends and identify important factors associated with Cesarean section (C-section), low birth-weight, and prematurity within the Hispanic population. We use data from the National Vital Statistics System (2011–2021), covering nearly all U.S. births. We compare outcomes across Hispanic, non-Hispanic White, and non-Hispanic Black mothers and further disaggregate by Hispanic origin (Mexican, Puerto Rican, Cuban, Central/South American, and Other/Unknown). We use logistic …


Effects Of Ambient Temperature On Nox Emissions From Heavy-Duty Diesel Vehicles Measured In Utah, Amber L. Gurecki Allen, Darrell B. Sonntag, Gary A. Bishop Aug 2025

Effects Of Ambient Temperature On Nox Emissions From Heavy-Duty Diesel Vehicles Measured In Utah, Amber L. Gurecki Allen, Darrell B. Sonntag, Gary A. Bishop

Fuel Efficiency Automobile Test Publications

This study investigates the effects of ambient temperature on NOx (NO + NO2) emissions from model year 2011 and later heavy-duty (HD) diesel vehicles. Emission measurements were collected in Perry, Utah, using the Fuel Efficiency Automobile Test (FEAT) remote sensing device. Data were limited to model year 2011 and later to focus on vehicles likely equipped with selective catalytic reduction (SCR) systems, which control tailpipe NOx emissions and are shown to be temperature sensitive. HD diesel vehicles measured in the winter of 2020 had consistently higher NOx emissions than those measured in the summer of 2023, most significantly for vehicles …


Projections Of Lightning‐Ignited Wildfire Risk In The Western United States, Dmitri A. Kalashnikov, John T. Abatzoglou, Frances V. Davenport, Zachary M. Labe, Paul C. Loikith, Danielle Touma, Deepti Singh Aug 2025

Projections Of Lightning‐Ignited Wildfire Risk In The Western United States, Dmitri A. Kalashnikov, John T. Abatzoglou, Frances V. Davenport, Zachary M. Labe, Paul C. Loikith, Danielle Touma, Deepti Singh

Geography Faculty Publications and Presentations

Cloud‐to‐ground (CG) lightning is a major source of summer wildfire ignition in the western United States (WUS). However, future projections of lightning are uncertain since lightning is not directly simulated by most global climate models. To address this issue, we use convolutional neural network (CNN)‐based parameterizations of daily June‐September CG lightning. CNN parameterizations of daily CG lightning occurrence at each grid cell use fields of three thermodynamic variables—ratio of surface Moist Static Energy (MSE) to 500 hPa saturation MSE, 700–500 hPa lapse rate, and 500 hPa relative humidity. Applying these parameterizations to the Community Earth System Model version 2 Large …


Exploring The Moderating Effect Of Boundary Management Strategy In A Remote Work Environment, Brandon M. Vasquez Aug 2025

Exploring The Moderating Effect Of Boundary Management Strategy In A Remote Work Environment, Brandon M. Vasquez

Master's Theses

Remote work has evolved significantly, especially during the COVID-19 pandemic, and continues to influence employee experiences in both positive and negative ways. Managing the separation between work and personal life is of importance. More specifically, using a boundary management strategy of segmentation may be more effective than an integration strategy because those who separate the two domains of work and family/personal life may be less prone to conflict in their lives. The present study aimed to examine the moderating effect of boundary management strategy on the relationship between remote work and job satisfaction, work-life balance, and well-being. Specifically, it was …


Phosphorylation Toggles The Sars-Cov-2 Nucleocapsid Protein Between Two Membrane-Associated Condensate States, Bruna Favetta, Huan Wang, Jasmine Cubuk, Arjun Singh, Mayur Barai, Cesar Ramirez, Haiyan Zheng, Adam J Gormley, N Sanjeeva Murthy, Gregory Dignon, Andrea Soranno, Zheng Shi, Benjamin S Schuster Aug 2025

Phosphorylation Toggles The Sars-Cov-2 Nucleocapsid Protein Between Two Membrane-Associated Condensate States, Bruna Favetta, Huan Wang, Jasmine Cubuk, Arjun Singh, Mayur Barai, Cesar Ramirez, Haiyan Zheng, Adam J Gormley, N Sanjeeva Murthy, Gregory Dignon, Andrea Soranno, Zheng Shi, Benjamin S Schuster

2020-Current year OA Pubs

The Nucleocapsid protein (N) of SARS-CoV-2 plays a critical role in the viral lifecycle by regulating RNA replication and by packaging the viral genome. N and RNA phase separate to form condensates that may be important for these functions. Both functions occur at membrane surfaces, but how N toggles between these two membrane-associated functional states is unclear. Here, we reveal that phosphorylation switches how N condensates interact with membranes, in part by modulating condensate material properties. Our studies also show that phosphorylation alters N's interaction with viral membrane proteins. We gain mechanistic insight through structural analysis and molecular simulations, which …


Artificial Intelligence In Ocular Transcriptomics: Applications Of Unsupervised And Supervised Learning, Catherine Lalman, Yimin Yang, Janice L. Walker Aug 2025

Artificial Intelligence In Ocular Transcriptomics: Applications Of Unsupervised And Supervised Learning, Catherine Lalman, Yimin Yang, Janice L. Walker

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Transcriptomic profiling is a powerful tool for dissecting the cellular and molecular complexity of ocular tissues, providing insights into retinal development, corneal disease, macular degeneration, and glaucoma. With the expansion of microarray, bulk RNA sequencing (RNA-seq), and single-cell RNA-seq technologies, artificial intelligence (AI) has emerged as a key strategy for analyzing high-dimensional gene expression data. This review synthesizes AI-enabled transcriptomic studies in ophthalmology from 2019 to 2025, highlighting how supervised and unsupervised machine learning (ML) methods have advanced biomarker discovery, cell type classification, and eye development and ocular disease modeling. Here, we discuss unsupervised techniques, such as principal component analysis …


Signaling By Intracellular Β2-Adrenergic Receptors Regulates Ampa Receptor Trafficking And Synaptic Plasticity, Boram Lee, Xiaomin Xing, Kyle E. Ireton, Bing Xu, Paul J. Gasser, Johannes W. Hell Aug 2025

Signaling By Intracellular Β2-Adrenergic Receptors Regulates Ampa Receptor Trafficking And Synaptic Plasticity, Boram Lee, Xiaomin Xing, Kyle E. Ireton, Bing Xu, Paul J. Gasser, Johannes W. Hell

Biomedical Sciences Faculty Research and Publications

Signaling by norepinephrine (NE) via adrenergic receptors (ARs) mediates attention, yet the underlying molecular mechanisms are largely unknown. AMPA receptors (AMPARs) form a complex with β2ARs, Gs, adenylyl cyclase, and protein kinase A (PKA) to augment AMPAR phosphorylation and, thereby, surface expression. We show that signaling by intracellular β2ARs is required for these effects and two different forms of long-term potentiation (LTP) that depend on β2AR signaling and phosphorylation of the AMPAR GluA1 subunit on S845. Inhibition of two NE transporters, the organic cation transporter 3 (OCT3) and the plasma membrane monoamine transporter (PMAT), impairs phosphorylation of the AMPAR GluA1 …


Effects Of Cryoprotective And Mitochondrial Stabilizing Agents On Vitrified Bovine Oocytes, Allison Hoang Aug 2025

Effects Of Cryoprotective And Mitochondrial Stabilizing Agents On Vitrified Bovine Oocytes, Allison Hoang

LSU Master's Theses

Oocyte vitrification success is highly dependent on cryoprotectant agent (CPA) choice as well as possible additives that could help preserve mitochondrial membrane potential (mMP), reactive oxygen species (ROS) production, and calcium homeostasis within the cell. It is a delicate balance between levels needed for proper oocyte function and activation and levels needed to induce apoptotic pathways. The results of oocyte cryopreservation determine the eventual oocyte viability and subsequent fertilization and embryo development.

In this study potential permeating cryoprotectant combinations were explored such as ethylene glycol (EG) and propylene glycol (PG) or EG in combination with dimethyl sulfoxide (DMSO). Also, the …


Cathartocytosis: Jettisoning Of Cellular Material During Reprogramming Of Differentiated Cells, Jeffrey W Brown, Xiaobo Lin, Gabriel Anthony Nicolazzi, Xuemei Liu, Thanh Nguyen, Megan D Radyk, Joseph Burclaff, Jason C Mills Aug 2025

Cathartocytosis: Jettisoning Of Cellular Material During Reprogramming Of Differentiated Cells, Jeffrey W Brown, Xiaobo Lin, Gabriel Anthony Nicolazzi, Xuemei Liu, Thanh Nguyen, Megan D Radyk, Joseph Burclaff, Jason C Mills

Faculty, Staff and Students Publications

Injury causes differentiated cells to undergo massive reprogramming to become proliferative and repair tissue via paligenosis. Gastric chief cells use paligenosis to reprogram into progenitor-like spasmolytic-polypeptide-expressing metaplasia (SPEM) cells. Stage 1 of paligenosis is the downscaling of mature cell architecture via a process involving lysosomes. Here, we notice that sulfated glycoproteins are not only digested during paligenosis but also excreted into the gland. Various genetic and pharmacological approaches show that endoplasmic reticulum membranes and secretory granule cargo are also excreted and that the process proceeds in parallel with but is mechanistically independent of autophagy. Three-dimensional light and electron microscopy demonstrated …


High-Speed Voltage Imaging Of Action Potentials In Molecular Layer Interneurons Reveals Sensory-Driven Synchrony That Augments Movement, Spencer T Brown, Meghana R Holla, Michelle A Land, Shuyuan Yang, Alex J Mcdonald, François St-Pierre, Indira M Raman Aug 2025

High-Speed Voltage Imaging Of Action Potentials In Molecular Layer Interneurons Reveals Sensory-Driven Synchrony That Augments Movement, Spencer T Brown, Meghana R Holla, Michelle A Land, Shuyuan Yang, Alex J Mcdonald, François St-Pierre, Indira M Raman

Faculty, Staff and Students Publications

Testing whether the synchrony of action potential firing is a cerebellar coding mechanism requires simultaneous recording, with high temporal fidelity, from populations of identified neurons. Here, we used targeted one-photon voltage imaging at 2–4 kHz to record action potentials from groups of ~10–300 molecular layer interneurons (MLIs) expressing a positively tuned, genetically encoded voltage indicator, FORCE1f or pAce. In awake resting mice, crus I MLIs fired brief (~1-ms) spikes at 20–60 spikes/s. Sensory stimuli of air puffs to the whiskers evoked short-latency (< 10 ms) increases in spiking probability. In most trials, >50% of MLIs fired synchronously with 4-ms temporal precision. The magnitude of puff-evoked whisks correlated tightly with …


Influenza-Associated Acute Necrotizing Encephalopathy In Us Children, Andrew Silverman, Rachel Walsh, Jonathan D Santoro, Katherine Thomas, Elizabeth Ballinger, Kristen S Fisher, Ajay X Thomas, Brian Appavu, Michael C Kruer, Derek Neilson, Jasmine Knoll, April N Sharp, Hannah E Edelman, Scott Otallah, Alexandra Morgan, Aniela Grzezulkowska, John Nguyen, Lekha M Rao, Shaina M Hecht, Laura Catalano, Hunter Daigle, Catherine Kronfol, Jessica Wharton, David Adams, Adam Z Kalawi, Michael Kung, Janetta L Arellano, Lauren Smith, Devorah Segal, Kristina Feja, Eileen Broomall, Anuj Jayakar, Sandra R Arnold, Hanna Retallack, Craig A Press, Grace Gombolay, Madeleine H Mclaughlin, Varun Kannan, Kavita Thakkar, Tasmia Rezwan, Erin Hulfish, Dalia Eid, Jennifer Meylor, Diane Peng, Ryan Hurtado, Taylor Nickerson, Iris Mandell, Abigail U Carbonell, Mallory Kerner-Rossi, Divya Jayaraman, Mallory Davis, Rosemary Olivero, Neel Shah, Christina M Osborne, Bo Zhang, Christopher Cortina, Adrienne G Randolph, Suchitra Rao, Thomas Larocca, Keith P Van Haren, Molly Wilson-Murphy Aug 2025

Influenza-Associated Acute Necrotizing Encephalopathy In Us Children, Andrew Silverman, Rachel Walsh, Jonathan D Santoro, Katherine Thomas, Elizabeth Ballinger, Kristen S Fisher, Ajay X Thomas, Brian Appavu, Michael C Kruer, Derek Neilson, Jasmine Knoll, April N Sharp, Hannah E Edelman, Scott Otallah, Alexandra Morgan, Aniela Grzezulkowska, John Nguyen, Lekha M Rao, Shaina M Hecht, Laura Catalano, Hunter Daigle, Catherine Kronfol, Jessica Wharton, David Adams, Adam Z Kalawi, Michael Kung, Janetta L Arellano, Lauren Smith, Devorah Segal, Kristina Feja, Eileen Broomall, Anuj Jayakar, Sandra R Arnold, Hanna Retallack, Craig A Press, Grace Gombolay, Madeleine H Mclaughlin, Varun Kannan, Kavita Thakkar, Tasmia Rezwan, Erin Hulfish, Dalia Eid, Jennifer Meylor, Diane Peng, Ryan Hurtado, Taylor Nickerson, Iris Mandell, Abigail U Carbonell, Mallory Kerner-Rossi, Divya Jayaraman, Mallory Davis, Rosemary Olivero, Neel Shah, Christina M Osborne, Bo Zhang, Christopher Cortina, Adrienne G Randolph, Suchitra Rao, Thomas Larocca, Keith P Van Haren, Molly Wilson-Murphy

Faculty, Staff and Students Publications

Importance: Acute necrotizing encephalopathy (ANE) is a rare, but severe, neurologic condition for which epidemiologic and management data remain limited. During the 2024-2025 US influenza season, clinicians at large pediatric centers anecdotally reported an increased number of children with influenza-associated ANE, prompting this national investigation.

Objective: To understand the clinical presentation, interventions, and outcomes among US children diagnosed with influenza-associated ANE.

Design, setting, and participants: This study was a multicenter case series of children diagnosed with ANE with longitudinal follow-up. A call for cases was issued via academic societies, public health agencies, and by directly contacting pediatric specialists at 76 …


Multiplex Imaging Mass Cytometry Reveals Prognostic Immunosuppressive Subpopulations And Macrophage-Driven Metastasis In Osteosarcoma, Benjamin B Gyau, Junyan Wang, Weiguo Wu, Brooks Scull, Angela M Major, Weidong Jin, Justin M M Cates, John Hicks, Tsz-Kwong Man Aug 2025

Multiplex Imaging Mass Cytometry Reveals Prognostic Immunosuppressive Subpopulations And Macrophage-Driven Metastasis In Osteosarcoma, Benjamin B Gyau, Junyan Wang, Weiguo Wu, Brooks Scull, Angela M Major, Weidong Jin, Justin M M Cates, John Hicks, Tsz-Kwong Man

Faculty, Staff and Students Publications

Osteosarcoma is a type of bone cancer that mostly affects kids and teens. The biggest danger is when the cancer spreads to the lungs, and current treatments do not work well for those cases. Immunotherapy, which helps the body’s immune system fight cancer, has worked for other cancers but is limited for osteosarcoma because we do not fully understand the environment around the tumor. Our research looked at various cells around the tumor to study why patients have worse outcomes. We found that certain cells, called M2 macrophages (M2) and myeloid-derived suppressor cells (MDSC), which weaken the immune system, are …


Computer-Aided Reading Of Chest Radiographs For Paediatric Tuberculosis: Current Status And Future Directions, Mackenzie Dupont, Robert Castro, Sandra V Kik, Megan Palmer, James A Seddon, Devan Jaganath Aug 2025

Computer-Aided Reading Of Chest Radiographs For Paediatric Tuberculosis: Current Status And Future Directions, Mackenzie Dupont, Robert Castro, Sandra V Kik, Megan Palmer, James A Seddon, Devan Jaganath

Faculty, Staff and Students Publications

Computer-aided detection (CAD) systems for automated reading of chest x-rays (CXRs) have been developed and approved for tuberculosis triage in adults but not in children. However, CXR is frequently the only adjunctive tool for clinical assessment in the evaluation of paediatric tuberculosis in primary care settings, and children would benefit from CAD models that can detect their unique clinical and radiographic features. To advance CAD for childhood tuberculosis, large, diverse paediatric CXR datasets linked to standardised tuberculosis classifications are required. These datasets would be used to train and validate paediatric-specific models for tuberculosis screening, diagnosis, and severity stratification. Previous studies …


Outcomes Of Brexucabtagene Autoleucel In Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia With Cns Involvement, Ibrahim N Muhsen, Gregory W Roloff, Rawan Faramand, Tamer Othman, Yannis Valtis, Noam E Kopmar, Simone E Dekker, Matthew Connor, Santiago Mercadal, Timothy E O'Connor, Kaitlyn C Dykes, Mohamed Ahmed, Nikeshan Jeyakumar, Amy Zhang, Katharine Miller, Katherine C Sutherland, Caitlin Guzowski, Vishal K Gupta, Navneet Majhail, Minoo Battiwalla, Melhem M Solh, Shahbaz A Malik, John Mathews, Caspian H Oliai, Paul Shaughnessy, Luke Mountjoy, Catherine J Lee, Aaron C Logan, Stephanie B Tsai, Jessica T Leonard, Marc Schwartz, Joshua P Sasine, Muthu Kumaran, Noelle Frey, Jae H Park, Divya Koura, Ryan D Cassaday, Bijal D Shah, Ibrahim Aldoss, Lori S Muffly, Laquisa C Hill Aug 2025

Outcomes Of Brexucabtagene Autoleucel In Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia With Cns Involvement, Ibrahim N Muhsen, Gregory W Roloff, Rawan Faramand, Tamer Othman, Yannis Valtis, Noam E Kopmar, Simone E Dekker, Matthew Connor, Santiago Mercadal, Timothy E O'Connor, Kaitlyn C Dykes, Mohamed Ahmed, Nikeshan Jeyakumar, Amy Zhang, Katharine Miller, Katherine C Sutherland, Caitlin Guzowski, Vishal K Gupta, Navneet Majhail, Minoo Battiwalla, Melhem M Solh, Shahbaz A Malik, John Mathews, Caspian H Oliai, Paul Shaughnessy, Luke Mountjoy, Catherine J Lee, Aaron C Logan, Stephanie B Tsai, Jessica T Leonard, Marc Schwartz, Joshua P Sasine, Muthu Kumaran, Noelle Frey, Jae H Park, Divya Koura, Ryan D Cassaday, Bijal D Shah, Ibrahim Aldoss, Lori S Muffly, Laquisa C Hill

Faculty, Staff and Students Publications

Patients with relapsed/refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL) with central nervous system (CNS) involvement (CNS B-ALL) have poor outcomes and were frequently excluded from CD19-targeting chimeric antigen receptor (CAR) T-cell clinical trials. The efficacy and safety of brexucabtagene autoleucel (brexu-cel) in adults with R/R B-ALL was established by the ZUMA-3 trial, which excluded patients with advanced or symptomatic CNS involvement. In this retrospective multicenter analysis, we investigated the safety and efficacy of brexu-cel in patients with CNS B-ALL using data from the ROCCA (Real-World Outcomes Collaborative for CAR T in ALL) consortium. Of 189 patients who received infusion, 31 …


Pfkfb3 Activates Cad To Enhance De Novo Pyrimidine Synthesis For Cell Growth, Qingen Da, Yongfeng Cai, Qian Ma, Qiuhua Yang, Yapeng Cao, Yaqi Zhou, Dingwei Zhao, Zhiping Liu, Jiean Xu, Junming Quan, Liang Zhang, Rui Wang, Xuejun Jiang, Xiao Liu, Kunfu Ouyang, Zhen Han, Jikui Liu, Tao Wang, Chunxiang Zhang, Neal L Weintraub, David J R Fulton, Jun Zhao, Mei Hong, Zigang Li, Yuqing Huo Aug 2025

Pfkfb3 Activates Cad To Enhance De Novo Pyrimidine Synthesis For Cell Growth, Qingen Da, Yongfeng Cai, Qian Ma, Qiuhua Yang, Yapeng Cao, Yaqi Zhou, Dingwei Zhao, Zhiping Liu, Jiean Xu, Junming Quan, Liang Zhang, Rui Wang, Xuejun Jiang, Xiao Liu, Kunfu Ouyang, Zhen Han, Jikui Liu, Tao Wang, Chunxiang Zhang, Neal L Weintraub, David J R Fulton, Jun Zhao, Mei Hong, Zigang Li, Yuqing Huo

Faculty, Staff and Students Publications

Aerobic glycolysis, termed the Warburg effect, is one of the aberrant metabolic pathways in highly proliferating cells. Glycolysis provides glycolytic metabolites to support the generation of biomass, such as nucleotides, amino acids, and lipids. Research on the direct interactions between glycolysis and other metabolic pathways is an emerging field that has garnered significant interest. Phosphofructokinase-2/fructose-2,6-bisphosphatase 3 (PFKFB3) activates glycolysis by synthesizing fructose-2,6-bisphosphate (F2,6BP), which allosterically activates the rate-limiting enzyme 6-phosphofructo-1-kinase (PFK-1). In this study, we found that PFKFB3 directly interacts with and regulates the phosphorylation of carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD), the enzyme catalyzing the first three …


37th Convocation Pakistan Aug 2025

37th Convocation Pakistan

Speeches from convocations, inaugurations, and major events

No abstract provided.


'What The World Would Be’: How Creating A Shared World Through Collaborative Roleplaying Helps Us Deal With Real-World Challenges, Pablo Muslera Aug 2025

'What The World Would Be’: How Creating A Shared World Through Collaborative Roleplaying Helps Us Deal With Real-World Challenges, Pablo Muslera

Imaginings: creative practice and inquiry

A creative prose artefact and critical exegesis illustrate how roleplaying games explore community and identity. A prose dramatisation of a cooperative TTRPG (table top roleplaying game) juxtaposes the collaboratively imagined world, and the reality from which it is an escape. Themes of gender identity, isolation, precarious work and fluctuating health are explored within the timeframe of the Covid outbreak in Adelaide mid-2020, with the roleplaying session serving as a respite from insecure work and health challenges, while supporting creative agency and the expression of meaningful selfhood through collaborative play and problem-solving. This reflects a broader phenomenon of the increased popularity …


The Monstrous Other: Exploring Negative Representations Of Queerness In Genre Cinema, Mark Gambino Aug 2025

The Monstrous Other: Exploring Negative Representations Of Queerness In Genre Cinema, Mark Gambino

Imaginings: creative practice and inquiry

The following literature review is an extract from my SAE University College Masters thesis, Disrupting negative representations of queerness in genre cinema, conferred in September 2024. The project explored representations of the queer Other in film horror, through artefact-exegesis, with the creative artefact, horror film Shadows, interrogating the coding of trans / queer characters as the ‘monstrous Other’ in the horror film genre, and how this notion can be subverted and transcended.


The Methodological Approach Of My Emergent Auto-Ethnographical Journey In Arts-Based Practice As Research (Abr): Music & Sound-Making, Meaning-Making, Self-Making, David L. Page Aug 2025

The Methodological Approach Of My Emergent Auto-Ethnographical Journey In Arts-Based Practice As Research (Abr): Music & Sound-Making, Meaning-Making, Self-Making, David L. Page

Imaginings: creative practice and inquiry

This article discusses the methodological approach of my professional Doctor of Creative Industries (DCI) Research Project 1 study. The aim of higher degree research (HDR) Project 1 was to investigate my DIY music & sound-making practice and self as a practitioner, in the process of creating and producing a DIY music artefact. Specifically: to investigate why I as the practitioner felt an authentic connection with one form of music & sound-making (acoustic instrument-based), and not a connection with another form of music & sound-making (digital virtual-based).


Montserrat Developments Impacting Local Coral Reefs, Emma I. Bartholomew Aug 2025

Montserrat Developments Impacting Local Coral Reefs, Emma I. Bartholomew

2025 Symposium

Montserrat is a small island in the Caribbean, and over half of the island is in the exclusion zone because of the active volcano, Soufrière Hills. In that half was the old capital, Plymouth, which has since been abandoned, and its old port. The old port was getting less reliable and accessible, so they decided to build a new port in Little Bay, closer to the seat of government in Brades. This study explored how the addition of the new port impacted the corals in that area. We explored several different bays and recorded the diversity and health of the …


Transforming Leadership Behaviors And Thriving Through The Storm In A High Reliability Organization, Rajveer Kaur, Jiji Andrews, Kambree Baxter Aug 2025

Transforming Leadership Behaviors And Thriving Through The Storm In A High Reliability Organization, Rajveer Kaur, Jiji Andrews, Kambree Baxter

Creating Healthy Work Environments (CHWE)

The structural inequities have affected critical care nurses, health care worker’s health and well-being (Durrah et al, 2022; Wells, S., 2024). Prioritizing nurse wellbeing has been formed to improve psychologically safe work environments associated with positively decreasing barriers in patient outcomes within the workforce (Wells, S., 2024). Authentic leaders developed patient advocacy, trusting relationships with their employees to increase the access to proper nursing services to enhance the ability to thrive at work ( Alhalal et al, 2024a; Durrah et al, 2022). Authentic leadership tool was introduced to design interventions and policies specifically for nurse manager’s authentic leadership style to …


Leveraging Meaningful Recognition To Create And Sustain Healthy Work Environments, Cindy Lefton Aug 2025

Leveraging Meaningful Recognition To Create And Sustain Healthy Work Environments, Cindy Lefton

Creating Healthy Work Environments (CHWE)

Meaningful recognition, a form of feedback describing how one makes a difference in the life of another, also serves to illustrate the elements of a healthy work environment in action. Focusing on meaningful recognition as a catalyst to shape and drive healthy work environments, attendees will be introduced to evidence-based budget neutral practices they can utilize to positively impact team members, workplace culture, and patient experience.


Transforming A Nurse Residency Program: Building Resilience To Enhance Professional Well-Being, Deborah Ambrosio Mawhirter, Maria L. Triolo Aug 2025

Transforming A Nurse Residency Program: Building Resilience To Enhance Professional Well-Being, Deborah Ambrosio Mawhirter, Maria L. Triolo

Creating Healthy Work Environments (CHWE)

Introduction: A nurse residency program fosters professional growth and aids in the transition into practice. As nurses enter the workforce, they may become overwhelmed and stressed. There is a growing recognition that nurses need assistance in developing skills for resilience. A process of adapting when faced with challenges such as stress and adversity. Educating nurses in a residency program by providing interventions to promote healthy behaviors, self- care and develop a resiliency plan enhances the work environment and allows nurses to flourish. Nurses that build self-care into personal resilience plans bolster individual wellness and promote wellness. Integrating a culture of …


Combining Organizational Assessment And Evidence-Based Strategies To Address Incivility In Nursing, Guillaume Ngonmeudje Aug 2025

Combining Organizational Assessment And Evidence-Based Strategies To Address Incivility In Nursing, Guillaume Ngonmeudje

Creating Healthy Work Environments (CHWE)

The workplace environment in healthcare is complex and negatively influenced by an increasing pattern of incivility. Recent reports of the increasing prevalence of incivility and related disruptive behaviors within nursing academic and clinical settings are alarming. Incivility threatens the sense of belonging needed to support and nurture the development of nursing students in the profession, and significantly impacts the work performance of front-line healthcare workers, contributing to medical errors and poor patient outcomes (Patel et al., 2022). Nurses and nursing students must be well equipped to effectively address incivility in the workplace and promote the collaboration necessary to optimize patient …


Enhancing Well-Being: Sensory Adhesive Strips And Box Breathing To Reduce Anxiety In Bsn Students, Beth Heuer, Tish Gill Aug 2025

Enhancing Well-Being: Sensory Adhesive Strips And Box Breathing To Reduce Anxiety In Bsn Students, Beth Heuer, Tish Gill

Creating Healthy Work Environments (CHWE)

In a recent meta-analysis, Vo et al.1 reported that most nursing students experienced moderate stress (42.1%) and mild to moderate anxiety (19.4%-25.1%). Both physiologic and psychological calming can be enhanced through controlled breathing techniques. Breathing techniques have emerged as potential tools for stress management and well-being. Controlled breathing influences respiratory rate by increasing vagal tone during slowed expiration.2 This reduction in respiratory rate can enhance mood and reduce negative emotions such as state anxiety.2

Recognizing the importance of addressing mental health in academic settings, this study was designed to teach a controlled breathing method (Box Breathing) to …


Aligning Operational Excellence With Sustainable Development Goals In A School Of Nursing, Ashley Leak Bryant, Gabrielle Leonard, Lakecha Alston, Julie Jacobson Vann, Valerie Howard Aug 2025

Aligning Operational Excellence With Sustainable Development Goals In A School Of Nursing, Ashley Leak Bryant, Gabrielle Leonard, Lakecha Alston, Julie Jacobson Vann, Valerie Howard

Creating Healthy Work Environments (CHWE)

Operational excellence is one of our priorities for the 2023-2028 strategic plan at our School of Nursing. The Office of Strategy and Global Affairs at UNC School of Nursing is committed to continuous improvement of sustainable operational excellence. The sustainable development goals/global goals were adopted by the United Nations in 2015, with a universal call to action to end poverty, protect the planet, and ensure that by 2030 all people enjoy peace and prosperity. The purpose is to present an overview of the formation, evolution, and evaluation of the Office of Strategy and Global Affairs in the School of Nursing …


Overcoming Challenges: Creating A Healthy Work Environment, Linda Eanes, Liji Mathew, Betty Phillips, Dalia Paul, Moncy Mathews Aug 2025

Overcoming Challenges: Creating A Healthy Work Environment, Linda Eanes, Liji Mathew, Betty Phillips, Dalia Paul, Moncy Mathews

Creating Healthy Work Environments (CHWE)

A healthy work environment improves patient outcomes and promotes resiliency by supporting the wellbeing of the nurses. The purpose of our study was to describe labor and delivery nurses’ experiences in caring for patients during the COVID-19 pandemic. We used a descriptive phenomenological design and purposeful sampling to recruit experienced labor and delivery nurses for flexible semi-structured face-to-face audiotaped interviews. Constant comparison was used to analyze data. Ten nurses employed in a labor and delivery unit in two acute care hospitals in southern Texas participated and were interviewed from June through August 2022.

Five distinct themes were identified: Psychological stress …


Finding The Right Fit: How Rotations And Mentorship Shape Successful Nursing Careers, Jessica Dunks, Lois Yearous, Judi Rhyner, Emily Calabro, Keith Jones, Earlene Reagan Aug 2025

Finding The Right Fit: How Rotations And Mentorship Shape Successful Nursing Careers, Jessica Dunks, Lois Yearous, Judi Rhyner, Emily Calabro, Keith Jones, Earlene Reagan

Creating Healthy Work Environments (CHWE)

Background: Nursing students often face challenges in gaining adequate exposure to diverse clinical settings. This can make choosing a first nursing job difficult, leading to potential dissatisfaction and turnover. In a 12-hospital system, a novel initiative was designed to address this issue by providing nursing students with immersive clinical experiences in various departments, facilitating a smoother transition into their professional nursing roles.

Methods: Nurse technicians (nurse techs) are nursing students hired into the system to gain hands-on experience. The pilot program was launched in May 2022 across 9 Collaborative Business Units (CBUs) within a hospital system in Washington state. The …


Social Capital In The Workplace For New Graduate Nurses: Maximizing Recruitment And Retention, Faye Ari Inumerables, Jennifer Emilie Mannino, Lisa A. Lumley, Kenya Williams, Pamela Watters, Fadjana Joseph, Kimberly Campbell-Taylor, Jennifer Hahl, Kathy Leistner, Mary Stevenson Aug 2025

Social Capital In The Workplace For New Graduate Nurses: Maximizing Recruitment And Retention, Faye Ari Inumerables, Jennifer Emilie Mannino, Lisa A. Lumley, Kenya Williams, Pamela Watters, Fadjana Joseph, Kimberly Campbell-Taylor, Jennifer Hahl, Kathy Leistner, Mary Stevenson

Creating Healthy Work Environments (CHWE)

Background: Given the widespread nursing shortages, prioritizing nurse recruitment and retention efforts is essential. Understanding the impact of new graduates' initial experiences on their decision to accept and remain in their roles is essential for educators, recruiters, and healthcare system administrators to gain valuable insights. Purpose: This study aimed to examine a national sample of new graduate nurses’ first job experiences through the lens of social capital. Theoretical Framework: Social capital (Bourdieu, 1986; Coleman, 1988; Putnam, 1994) asserts that social relationships create valuable networks that serve as resources to their members, extending reciprocal benefits for individuals and the organization, building …