Digital Commons Network^™

Loss Of Dihydroceramide Desaturase Drives Neurodegeneration By Disrupting Endoplasmic Reticulum And Lipid Droplet Homeostasis In Glial Cells, Yuqing Zhu, Kevin Cho, Haluk Lacin, Yi Zhu, Jose T Dipaola, Beth A Wilson, Gary Patti, James B Skeath

2020-Current year OA Pubs

Dihydroceramide desaturases convert dihydroceramides to ceramides, the precursors of all complex sphingolipids. Reduction of DEGS1 dihydroceramide desaturase function causes pediatric neurodegenerative disorder hypomyelinating leukodystrophy-18 (HLD-18). We discovered that

It Takes A Village: Addressing Community Needs To Implement Firearm Prohibitions For Domestic Violence Protective Order Respondents, Kellie R Lynch, Michael K Gusmano, Jeff R Temple, Sarah Lane

Faculty, Staff and Student Publications

Prohibiting domestic violence protective order (DVPO) respondents from firearms is an effective strategy to prevent intimate partner homicide. However, DVPO gun laws vary considerably across states, and the implementation of such laws is inconsistent across localities. Local context, such as resource availability, priorities, and politics, differs across types of communities and impacts the implementation of laws. We conducted in-depth key informant interviews with victim service and criminal justice professionals (N = 27) working in urban communities, rural communities, and statewide organizations to better understand: (a) what communities need to effectively prohibit DVPO respondents from firearms (i.e., the DVPO gun …

Epidemiology Of Shoulder Dislocations In The United States From 1990 To 2019: A Temporal Study Using The Global Burden Of Disease Database, Gabrielle Dykhouse, Ambrose Loc T. Ngo, Phillip C. Mckegg, Peter B. Spencer, Arsalaan Sayyed, Taylor J. Manes, Morgan Turnow, Nathaniel Long

Student Publications

Introduction

The shoulder joint is a common site for joint dislocation, with many individuals suffering from recurrent dislocations following treatment. The purpose of this study was to evaluate the epidemiology of shoulder dislocations in the United States from 1990 to 2019.

Methods

The Global Burden of Disease database was utilized to collect epidemiological data on shoulder dislocations in the United States (U.S.) from 1990 to 2019. These data included age-standardized rates of years lived with disability (YLDs), prevalence rates, and incidence rates per 100,000 people. Using the U.S. Census Bureau definitions, the data were stratified into four regions: the Northeast, …

Educator, Community And Student Reflections On Community-Engaged Research And Learning For Mathematics, Gareth A. Tribello, Jason Donaghy, Jyoutir Raj, Joshua Cunningham, Daniel Pyper, David Heaney, Kai Q. Lian, Sarah Conway, Judy Williams, Emma Mckenna

Irish Journal of Academic Practice

Community-engaged research and learning (CERL) is a constructivist pedagogy that involves students working on projects in collaboration with community partners. This approach was introduced to universities in the late 1960s, and although some disciplines have wholeheartedly embraced it, it is still rarely used in mathematics. This paper consists of a series of reflections written by educators, students, community partners and university leaders about a module in a mathematics degree that includes an element of CERL. These reflections demonstrate that community partners find value in the work done by mathematics students and that university leaders are broadly supportive of efforts to …

Poster: Threat Intelligence & Modeling Practices For Iomt Devices Using Wi-Fi Communications, Eva Wilson, Cody Ourique, Bernardo Flores

Faculty Research, Scholarly, and Creative Activity

The integration of internet connectivity into medical devices, known as the Internet of Medical Things (IoMT), is revolutionizing modern healthcare through remote monitoring and advanced diagnostics. Among these devices, the Continuous Positive Airway Pressure (CPAP) machine plays a critical role in managing patients with Sleep Apnea. However, the security of CPAP devices presents significant concerns due to potential vulnerabilities that could lead to critical failures, such as device shutdowns. An analysis was made of the device's connectivity interface, to identify potential exploit points and vulnerabilities. Additionally, we evaluated whether existing threat modeling frameworks - namely the MITRE Adversarial Tactics, Techniques, …

Heterozygous Variants In Plcg1 Affect Hearing, Vision, Cardiac, And Immune Function, Mengqi Ma, Yiming Zheng, Mingxi Deng, Shenzhao Lu, Xueyang Pan, Xi Luo, Michelle Etoundi, David Li-Kroeger, Kim C Worley, Lindsay C Burrage, Lauren S Blieden, Aimee Allworth, Wei-Liang Chen, Giuseppe Merla, Barbara Mandriani, Catherine E Otten, Pierre Blanc, Jill A Rosenfeld, Debdeep Dutta, Shinya Yamamoto, Michael F Wangler, Ian A Glass, Jingheng Chen, Elizabeth Blue, Paolo Prontera, Jeremie Rosain, Sandrine Marlin, Seema R Lalani, Hugo J Bellen, Undiagnosed Diseases Network

Duncan NRI Faculty and Staff Publications

Phospholipase C isozymes (PLCs) hydrolyze phosphatidylinositol 4,5-bisphosphate (PIP₂) into inositol 1,4,5-trisphosphate (IP₃) and diacylglycerol (DAG), important signaling molecules involved in many cellular processes including Ca²⁺ release from the endoplasmic reticulum (ER). PLCG1 encodes the PLCγ1 isozyme that is broadly expressed. Hyperactive somatic mutations of PLCG1 are observed in multiple cancers, but only one germline variant has been reported. Here, we describe seven individuals with heterozygous missense variants in PLCG1 [p.(Asp1019Gly), p.(His380Arg), p.(Asp1165Gly), and p.(Leu597Phe)] who present with hearing impairment (5/7), ocular pathology (4/7), cardiac septal defects (3/6), and various immunological issues (5/7). To model these …

A Protective Role Of Src-1 Against Aging Associated Cognitive Decline, Hesong Liu, Yongjie Yang, Jonathan C Bean, Yang He, Hailan Liu, Rambabu Majji, Chen Liang, Nan Zhang, Meng Yu, Longlong Tu, Qingzhuo Liu, Yue Deng, Kristine M Conde, Na Yin, Mengjie Wang, Yongxiang Li, Junying Han, Sanika Vattakuzhiyil Jossy, Megan Elyse Burt, Hari Krishna Yalamanchili, Chunmei Wang

Duncan NRI Faculty and Staff Publications

Introduction: Research indicates a strong correlation between obesity and the risk of dementia, both are linked to steroid receptor coactivator-1 (SRC-1), a transcriptional coactivator.

Methods: We used RNA sequencing analysis (RNA-Seq) to investigate the transcriptome of SRC-1-KO mice, and identified S100 calcium-binding protein A6 (S100A6), an AD associated gene, as one target of SRC-1. We tested cognitive behaviors in SRC-1-KO mice and mice with a humanized SRC-1 mutation (SRC-1L1376P), and performed promoter luciferase assays on S100A6.

Results: Loss of SRC-1 caused alterations in gene signatures that are commonly associated with neurodegenerative diseases, including AD, and diminished the neural plasticity of …

Nf1-Depleted Er+ Breast Cancers Are Differentially Sensitive To Cdk4/6 Inhibitors, Ze-Yi Zheng, Anran Chen, Eric J Jaehnig, Meenakshi Anurag, Jonathan T Lei, Long Feng, Chenwei Wang, Diana Fandino, Purba Singh, Hilda Kennedy, Ghazal Yadav, Craig T Vollert, Jill Tsai, Xi Chen, Yi Li, Bora Lim, Alastair Thompson, Shunqiang Li, Charles E Foulds, Bing Zhang, Matthew J Ellis, Eric C Chang

Faculty, Staff and Students Publications

Neurofibromin/NF1 is a RAS (rat sarcoma virus) GTPase activating protein and estrogen receptor (ER) transcriptional corepressor. NF1low status, identified by copy number loss or low mRNA/protein expression is associated with endocrine therapy resistance in approximately 20% of ER+/HER2− (human epidermal growth factor receptor 2) early-stage breast cancers. The identification of targeted treatments for NF1low ER+/HER2− breast cancer is therefore a priority. In this study proteogenomic analysis of ER+/HER2− breast cancer demonstrated that NF1low tumors exhibited elevated cyclin-dependent kinase 4/6 (CDK4/6) activity. In cell lines, NF1-deletion had a dual effect on CDK4 activity. First, by promoting ER recruitment to CCND1 …

The Perception Of Hooliganism And Its Impact Among Naia Collegiate Soccer Players, Eric Street, Fred Cromartie, Steve S. Chen, Brandon Spradley

Findings in Sport, Hospitality, Entertainment, and Event Management

There have been multiple studies with regard to the different aspects of soccer hooliganism throughout the world. Most commonly, studies of hooliganism covered areas such as harassment, vandalism, fighting, theft, public intoxication, and crowd disorder revolving around the games of soccer in various countries. This phenomenon has been studied among the major four professional sports in the United States, yet there has been no extensive research on soccer “hooliganism” associated with Major League Soccer (MLS). This study examined the survey responses from 101 National Association of Intercollegiate Athletics (NAIA) soccer players to identify their perceptions on severity of hooliganism and …

Implementation Of An Evidence-Based Emotional Wellness Program For First-Semester Nursing Students, Alana L. Long

Creating Healthy Work Environments (CHWE)

First-semester nursing student attrition rates average 35% in a community college located in the Mid-Atlantic region of the United States, with high-stress levels identified as a primary contributing factor. Addressing emotional wellness is critical to mitigating stress and improving retention among nursing students. This project implemented a 4-week evidence-based emotional wellness program to enhance students’ coping strategies, reduce perceived stress, and promote overall well-being. The Iowa Model of Evidence-Based Practice guided the development and implementation of the program, which included microlearning modules, nature-based experiential learning, meditation, and holistic activities. First-semester nursing students enrolled in a fundamentals of nursing course were …

Mhealth For Nurses' Mental Health, Cynthia Moore

Creating Healthy Work Environments (CHWE)

Background: Post-pandemic surveys show continue to show high rates of exhaustion, burnout, anxiety, and intention to leave the job in hospital nurses. Early-career nurses who experience burnout and exhaustion in the first 1-3 years of their career have a job turnover rate of approximately 46%, and are more prone to physical complaints, insomnia, and cognitive problems 10 years later. Few studies have focused on using mental health mobile apps (mHealth) in the hospital nurse population to help decrease the negative effects of a stressful work environment.

Purpose: This randomized controlled trial (RCT) pilot study has three aims: 1. to determine …

Hippocrates And Nightingale: Ancient Medicine And Modern Nursing, Callie Wiedle

Creating Healthy Work Environments (CHWE)

This presentation aims to examine and understand the influence that Hippocrates’ fundamental theories of medicine had on Florence Nightingale’s development of modern nursing care. Hippocrates has gained the nickname “the father of modern medicine” and Nightingale has claimed the title “the mother of modern nursing”. This presentation will argue that without Hipporcates’ revolutionary ideas in medicine the framework of modern nursing would have taken much longer to develop, if it was ever developed into what we know today. Nightingale took Hippocrates’ revolutionary ideas regarding hygiene, the environment, and holistic patient care; and adapted them into the systematic approach to modern …

Education, Evaluation, And Impact Of A Delegation Learning Session In The Care Pair Model, Tiffany Michelle Whitney

Creating Healthy Work Environments (CHWE)

This study examines the relationship of a structured educational intervention related to registered nurse (RN) delegated practice within the Care Pair Model (CPM) in a medical-surgical unit for its potential to expand the utilization of Nursing Assistants (NAs) in the nursing shortage in health care. CPM employs NAs as complement staff for RNs thus shortening workloads and improving patient care but relies on the RN's ability to communicate clearly and delegate responsibilities. A literature review done identifies that there is a gap in available information about CPM and delegation and thus this study looks at the educational intervention of delegation. …

Implementing Adjunct Surgical Count Technology, Herschel Bernard Holden

Creating Healthy Work Environments (CHWE)

Adjunct surgical count technology refers to advanced methods and systems designed to enhance the accuracy and efficiency of surgical counts, which are critical for preventing unintended retained surgical sponges. This technology often incorporates digital tools like barcode scanning, radiofrequency identification (RFID), and intelligent surgical sponges. Automating the counting process reduces human error, allowing for real-time tracking of sponges throughout the surgical procedure. This can involve using handheld devices or integrated systems that automatically log usage. The systems integrate with the electronic health record (EHR) and surgical management systems, providing comprehensive tracking reporting capabilities. This integration facilitates better communication among surgical …

Fast Births, Ready Nurses: Simulation Training For Emergency Nurses, Jamie Clemons

Creating Healthy Work Environments (CHWE)

The High-Fidelity Precipitous Delivery Management Simulation (PDM HFS) program was developed to address the critical need for specialized training among emergency department nurses, especially in rural communities where access to obstetric services is increasingly limited. As labor and delivery units continue to close, the responsibility for emergency departments to assume greater responsibility for managing precipitous deliveries and associated complications is increasing. The PDM HFS training program aims to enhance emergency department nurses' self-efficacy and clinical skills through high-fidelity simulation training, ultimately improving maternal outcomes. This study aims to evaluate the impact of the PDM HFS program in preparing emergency department …

Reminisce And Relive Joyful Memories Despite Dementia, Candice Cacal Nono

Creating Healthy Work Environments (CHWE)

Background: Dementia is a progressive neurological disease that affects cognition and behavioral and mood impairments, such as depression, that must be addressed. The DNP Project implemented an evidence-based intervention to improve healthcare outcomes involving depression in patients with dementia in a long-term care setting.

Problem: Dementia is a progressive neurological disease affecting mood and conditions that can lead to depression, affecting a patient’s quality of life. A quality improvement project was implemented in a long term care facility in Chicago, Illinois.

Methods: Eight residents with mild to moderate dementia participated in an eight-week Group Reminiscence Therapy program to measure the …

My Time With The Fusion Industry Association (“Fia”): Future-Focused Policy For A Fusion-Powered America, Erik J. Rorem

The Dialogue

No abstract provided.

Race To Robustness: Adaptation To Globalization In Authoritarian Regimes Of The Middle East, Lexi Eid

The Dialogue

The Middle East has been notably absent from the wave of democratization and failed to adapt to globalization since the 1990s. In the Middle Eastern countries, the economy has largely stagnated and the political system has remained authoritarian despite popular revolts during the Arab Spring. Earlier literature often emphasized the cultural and religious differences between the Middle East and the rest of the world. However, the Arab Spring proved that the Middle East could be a part of the democratization wave. More recent literature attempts to explain this surge of public response to the regime and explores how the authoritarian …

Unearthing The Promise And Peril Of Superfund Crackdowns With Esg, Abigail Kenwood

The Dialogue

No abstract provided.

Constraints And Conservatism: The Effect Of Presidential Choices On Voting Patterns Of Supreme Court Justices, Tyler Mccall

The Dialogue

The decisions of the Supreme Court are constantly featured in news headlines with the accusation that the core institution of the judicial branch is completely politicized. In fact, justices are directly chosen by presidents who have clear political and constitutional agendas. But what about justices whose voting behavior and opinions seem less politically motivated than others? One major answer to that query may lie in the difference between constrained and unconstrained choices. When a president chooses a nominee based on political promises made or limitations imposed by other branches of government, that choice is constrained because those nominees must appeal …

Understanding Child Noncompliance In The Early Care Setting, Melody Mann

McNair Research Journal SJSU

This study examines how teachers respond to children’s noncompliance in

early care settings. This structured observational study will focus on the

moment-to-moment interactions occurring within the preschool classroom

between both the child and teacher. It is predicted that (1) teacher’s direct

bids to children will promote greater instances of child compliance than

indirect bids, and (2) teachers’ responsive language will promote greater

instances of child compliance than restrictive language. The results of this

study will contribute to existing knowledge about the nature of teacher

child interactions in the early care settings.

Increasing And Improving Diversity And Hiring Of Individuals With Disabilities In The Workplace, Joshua Zhang

McNair Research Journal SJSU

This paper is a literature review of several literature on disability, diversity,

human resource/human resource management, and hiring in the

workplace/organization. The research question is how can employers

improve and increase hiring of individuals with disabilities in their

organizations? The objectives of this literature review paper are 1. Research

and analyze existing literature on disability, diversity, and workplace hiring,

2. Identify any limitations in gaps in research literature, and 3. Propose and

suggest areas and topics for future research. Each of the academic sources

in this paper are presented and discussed along with analysis. Additionally,

recommendations on how to best …

Same Face, Different Name - Colonialism, Colonization, And Capitalism: How To Combat The Insidious Capitalist Individualism That Denies Basic Human Rights To Us Citizens Via Community Centric Bartering, Nadia Loney

McNair Research Journal SJSU

This paper examines the effects of colonialism, colonization, and capitalism

on the social fabric of the United States and how severing key connections

within society has hindered the direct benefits of community. As has been

tested in various cities around the world, intentional bartering can create a

sustainable community and combat the devastating effects that these

systems have had on the environment and the escalation of violence both

internally and globally. Art aimed at community rebuilding and a

decentralization of the US dollar, can help facilitate innovation that heal

various social wounds.

Conscious Control: A Case Study On Self-Monitoring And Interventions In Maladaptive Daydreaming, Caleb Chan

McNair Research Journal SJSU

Maladaptive daydreaming (MD) is a persistent mental activity

characterized by immersive, excessive daydreaming that disrupts daily

life. This study examines the effectiveness of self-regulation strategies

in managing MD, including cognitive techniques, behavioral

adjustments, technology-assisted cues, and environmental

modifications. Using a single-subject ABA design, each intervention

phase lasted one week, with MD episodes tracked through self-reported

diaries and EEG monitoring. The results demonstrated that cognitive

reframing and task switching produced the most sustained reductions in

MD episodes, while technology-assisted cues had diminishing

effectiveness over time due to adaptation. Environmental modifications,

particularly workspace reorganization, con- tributed to long-term

improvements, while lighting adjustments …

Confronting The Digital Epidemic: Excessive Social Media Use (Smu) In The Wellbeing Of Young Adult Populations, Joanna Abellera

McNair Research Journal SJSU

This study will investigate the relationship between social media as a

mediator and its effects on depressive symptoms, using Social Comparisons

theory (SCT; Festinger, 1954) as a framework. A series of 8-10 articles,

obtained through the San Jose State Library Database and PsycINFO, will

explore the nature of social media addiction (SMA) and problematic social

media use (PSMU) and its relation to self-esteem of young adult

populations by comparing theoretical perspectives (i.e., cross-sectional and

experimental designs) in the literature. Studies have found that [increased

SMU has been correlated with negative outcomes such as depression,

loneliness, and increased envy]. Future studies …

Full Issue

McNair Research Journal SJSU

No abstract provided.

How Can A Strategic Plan Create And Sustain A Healthy Work Environment In The School Of Nursing?, Ashley Leak Bryant, Gabrielle Leonard, Lakecha Alston, Valerie Howard

Creating Healthy Work Environments (CHWE)

To achieve the sustainable development goals by 2030, our School of Nursing is addressing how we create and sustain a healthy environment as we lead our profession and improve lives for the public good. Our School of Nursing’s strategic plan has 3 mission critical priorities: responsible growth, inclusive excellence, and operational excellence. The Office of Strategy and Global Affairs aligned our global priorities with the School of Nursing's strategic plan: global education, Fulbright Specialist/Scholar and Visiting Professorships, and sustainability. In this presentation, we provide 3 examples of how our School of Nursing is creating and sustaining a healthy work environment …

Development Of An Integrative Health And Holistic Nursing Fellowship Program, Katrina Vigo, Annie Kaplon

Creating Healthy Work Environments (CHWE)

Nurses are at increased risk of burnout due to the high levels of stress in the healthcare work environment. Furthermore, burnout has negative effects on one’s physical, emotional, and behavioral health and can be linked to harmful clinical outcomes (Hetzel-Riggin, Swords, Tuang, Deck, & Spurgeon 2020). The development of a holistic, integrative health fellowship provides nurses with knowledge related to holistic nursing, integrative health, and the mind-body connection while equipping them with practical resiliency and coping skills to enhance their own personal and professional wellbeing and the wellbeing of patients, caregivers, and colleagues. Incorporating holistic nursing theory (American Holistic Nurses …

Utilizing Evidence To Increase Knowledge Of Best Practices To Prevent Bloodborne Pathogen Exposures, Alyssa Macmurphey

Creating Healthy Work Environments (CHWE)

Background: Nurses (RNs) are at risk for exposure to bloodborne pathogens (BBPs) like HIV and Hepatitis B and C. In 2023 at a Sacramento, CA level I trauma center there were 412 BBP exposures (BBPEs) reported, 143 involving RNs, costing the institution well over $700,000 on lab costs and exposure medications. Indirect costs of these exposures include lost work time, anxiety, and job burnout. BBPEs can be prevented with safety devices, best practices, and PPE use. Preventable BBPEs occur due to a lack of knowledge of these best practices. Prior to this project at this institution there was no in-person …

Rewind And Reflect: Using Video Elicitation To Enhance Virtual Patient Care, Paula Dianne Koppel, Michelle Webb, Jennie De Gagne, Paige Randall, Denise Napveux, Janelle Bludorn, Neil Prose, Aviva Emmons

Creating Healthy Work Environments (CHWE)

Background: Videoconferencing visits (VV) are an important medium for delivering healthcare worldwide, but clinicians remain uncertain about how to establish rapport in telehealth.^1,2 Teaching rapport-building to practicing clinicians who must adapt established behaviors for VV, requires more than providing information. While simulation and debriefing are effective in prelicensure programs,³ they are less feasible for established practitioners. Reviewing video recordings of actual patient encounters, however, is a useful strategy for changing practice patterns.^4-7 When clinicians view video recordings of their own patient interactions, it encourages them to discuss ideas not typically addressed and reveal tacit knowledge and skills …