Digital Commons Network^™

How Life-Cycle Real-World Evidence Can Bridge Evidentiary Gaps In Precision Oncology, Emanuel Krebs, Deirdre Weymann, Tania M. Bubela, Dean A. Regier

Office of the Provost

Precision oncology uses omics-based diagnostic technologies to inform histology-agnostic cancer treatment. To date, health system implementation remains limited owing to high uncertainty in regulatory and reimbursement evidence submissions. In this perspective, we describe a life-cycle approach to the evaluation of precision oncology technologies that addresses evidentiary uncertainty and is grounded in real-world evidence (RWE) derived using data routinely collected by healthcare systems. We consider the role for RWE in international regulatory and reimbursement decision-making, review common biases for observational precision oncology evaluations, make specific recommendations for RWE study design and analysis, and specify healthcare system requirements for data collection. We …

Crow's Nest, September 2, 2025, Crow's Nest Staff

Crow's Nest

The September 2, 2025, issue of Crow's Nest.

Climate-Induced Redistribution Of People Is Not Inveitable, Ingird Boas, Harald Sterly, Carol Farbotok, Mike Hulme, Hélène Benveniste, Kerilyn D. Schewel, Giovanni Betini, Marion Borderon, Roman Hoffmann, Kees Van Der Geest, David Durand-Delacre, Jan Selby, David J. Wrathall, Andrew Baldwin, Ailín Benítez Cortés, Kaderi N. Bukari, Simon Bunchuay-Peth, Simona Capisani, Samuel Nii Ardey Codjoe, Ruben Dahm, Camelia Dewan, Huub Dijstelbloem, Sonja Fransen, François Gemenne, Michele Dalla Fontana, Dorotha Hilhorst, Monica V. Iyer, Maggi W H Leung, Bishawjit Mallick, Kasia Paprocki, Meg Parsons, Patrick Sakdapolrak, Alex De Sherbinin, Farhana Sultana, Tearinaki P P Tanielu, Merewalesi Yee, Caroline Zickgraf

Geography and the Environment - All Scholarship

No abstract provided.

Synthetic Plasmodium Antigens, Compositions, And Uses Thereof, John H. Adams, Christopher L. King, Niraj H. Tolia, Edwin Chen, Nichole Diane Salinas, Miriam Thankam George, Francis B. Ntumngia, Samantha Jones Barnes

USF Patents

Provided herein are synthetic P. vivax antigens, antibodies and pharmaceutical formulations and vaccines thereof. Also provided herein are methods of treating and/or preventing Plasmodium infection and/or disease by administering the synthetic P. vivax antigens, antibodies and pharmaceutical formulations and vaccines thereof.

Lemena Holdings Llc V. Wo Kee Noodle Inc.

All Decisions

The court denied the tenant's motion to dismiss the nonpayment petition, which was based on a claim of res judicata from a prior dismissed case. The court found that the previous dismissal was due to a **defective rent demand**, a procedural prerequisite, and not a decision on the merits of the underlying claim for rent. Therefore, the doctrine of **res judicata** did not apply to bar the landlord from commencing a new proceeding after correcting the deficiency in the predicate notice. The court reasoned that a dismissal based on a failure to comply with a preliminary act does not preclude …

Enhancing Evidence-Based Practice: Picot Search In Cinahl Database – Evidence-Based Practice Council Monthly Meeting, Evelyn Wang

HSLIC Faculty and Staff Instructional Resources

This presentation introduces the PICOT Search feature in the CINAHL Database, demonstrating steps to activate PICOT on EBSCOhost and its application for precise clinical literature searches. The session provides practical guidance for clinicians and researchers to utilize evidence-based resources efficiently.

Good Newsletter September 2, 2025, Seattle University School Of Law Dean

GOOD NEWSletter

No abstract provided.

Students, Young Alumni Awarded National Scholarships To Study, Teach Abroad, Dave Larsen, Emily Clemenson

College of Arts and Sciences Newsroom

Students and recent graduates studied and taught in Bulgaria, Spain and the Netherlands

Clinical Testing For Covid-19, Influenza, And Rsv In Hospitalized Youths, 2016-2024., Ariana P. Toepfer, Rachel E. Rutkowski, Leila C. Sahni, Geoffrey A. Weinberg, Marian G. Michaels, Rangaraj Selvarangan, Mary Allen Staat, Natasha Halasa, Janet A. Englund, Julie A. Boom, Peter G. Szilagyi, Jennifer E. Schuster, Elizabeth P P. Schlaudecker, Laura S. Stewart, Eileen J. Klein, Samantha M. Olson, Sascha Ellington, Meredith L. Mcmorrow, Heidi L. Moline, Fatimah S. Dawood, New Vaccine Surveillance Network Collaborators

Manuscripts, Articles, Book Chapters and Other Papers

IMPORTANCE: Studies of COVID-19, influenza, and respiratory syncytial virus (RSV) disease clinical epidemiology, disease burden, and vaccine effectiveness often rely on clinical testing to identify cases, particularly with increasing use of electronic health record data. However, few data are available describing clinical testing practices to inform interpretation of these studies.

OBJECTIVE: To characterize clinical testing frequency for SARS-CoV-2, influenza, and RSV among children and adolescents hospitalized with acute respiratory illness during the 2016 to 2024 respiratory illness seasons by age, intensive care unit admission, and time period (2016-2020 and each season in 2020-2024); estimate the case fraction missed by clinical …

Comparison Of Crotalidae Immune F(Ab')2 (Equine) And Crotalidae Polyvalent Immune Fab (Ovine) At Establishing Control Of Initial Envenomation Symptoms In Louisiana Agkistrodon Envenomations, Taylor Sanders, Christine Murphy, Greggory Davis, Christina Aspinwall, Lauren Theriot, Christopher Mcvicker, Thomas Arnold

School of Medicine Faculty Publications

INTRODUCTION: Copperheads and cottonmouths are responsible for most snake envenomations in Louisiana. While the United States Food and Drug Administration has approved both Crotalidae polyvalent immune Fab (FabAV) and Crotalidae immune F(ab') (Fab2AV) for Agkistrodon envenomations, data is limited comparing their efficacies for this indication. METHODS: This is a retrospective study comparing FabAV to Fab2AV in the treatment of suspected Agkistrodon envenomations in Louisiana between April 2017 and October 2024. Cases identifying rattlesnakes were excluded. The primary outcome was the need for additional antivenom doses to achieve control after the initial antivenom dose. RESULTS: One hundred fifty-eight patients received FabAV …

Emerging Clinical Role Of Tavapadon, A Novel Dopamine Partial Agonist, In The Treatment Of Parkinson’S Disease, Alan D. Kaye, Bennett M. Ford, Brennan M. Abbott, Kalob M. Broocks, Sofia Novacic, Sahar Shekoohi

School of Medicine Faculty Publications

Tavapadon, a novel oral dopamine-D1R/D5R partial agonist, has been studied in recent years for the treatment of late-stage development Parkinson’s disease (PD). Levodopa, a dopamine precursor that currently remains the gold-standard first-line therapy for PD motor symptoms, serves as a benchmark against emerging dopaminergic agents. By selectively activating D1-family receptors on direct-pathway medium neurons, Tavapadon differs in that it delivers levodopa-level motor benefit while avoiding its many D2R/D3R-mediated adverse effects. In placebo-controlled trials, Tavapadon produced clear, clinically meaningful gains in motor function and day-to-day activities, as captured by the Unified Parkinson’s Disease Rating Scale (UPDRS). Recent late-stage results have revealed …

Opportunities And Challenges Of Artificial Intelligence Adoption In Democratization And Public Policy: A Case Study Of The Tangerang Live Application, Anis Fuad, Shanty Kartika Dewi, Yusa Djuyandi

Jurnal Wacana Politik

This study examines the role of the Tangerang LIVE application in promoting democratization and public policy through digital innovation. The approach used is exploratory qualitative, with literature studies, document analysis, and non-participatory observation of citizen interactions—including user reviews, agency responses, and bold media—from May 2024 to March 2025. Data were analyzed using thematic techniques assisted by NVivo, with validation through source triangulation. The focus of the study encompasses (1) citizen accessibility and participation (e-participation), (2) government transparency and accountability, and (3) digital democracy practices, including evidence-based policy deliberations. The results show that the LAKSA feature in Tangerang LIVE provides a …

Resilience As Resistance: Political Discourses Of Climate Adaptation Among Smallholder Coffee Farmers In Forest Conflict Zones Of Central Aceh Indonesia, Vellayati Hajad, Ikhsan Ikhsan, Nabila Hilmy Zafira, Sarini Vita Dewi

Jurnal Wacana Politik

Climate change has exerted significant social, economic, and environmental pressures on small-scale coffee farmers, particularly those living near protected forest areas. Declining yields, land limitations, and restrictive conservation policies have created complex tensions related to resource access and survival strategies. This study aims to analyze the political discourses embedded in the dynamics of land rights disputes and climate adaptation strategies of small-scale coffee farmers. Using a qualitative approach and Critical Discourse Analysis (CDA), the study explores how farmers negotiate, reject, and reinterpret state environmental regulations through everyday practices and narratives. This study’s findings reveal that coffee farmers’ adaptation strategies are …

Human Resource Management Practices And Employee Commitment In Public Agencies: A Sustainable Workforce Development Perspective From Enugu City, Nigeria, Chukwuebuka Victor Okorie, Leilani I. De Guzman

Journal of Management for Global Sustainability

This study investigates the implementation of sustainable human resource management (HRM) practices and their influence on employee commitment within public agencies in Enugu City, Nigeria. Anchored primarily in Social Exchange Theory (SET), the research explores how specific HRM practices—recruitment, training, rewards, and career management—affect affective, continuance, and normative commitment among customer relations employees. Employing a concurrent mixed-methods design, the study gathered quantitative data via structured questionnaires from 300 employees across five public institutions and qualitative insights through semi-structured interviews with 15 employees. Findings indicate a moderate application of sustainable HRM practices, with training perceived most favorably. Employee commitment levels were …

Integrated Clinical Research Ensembles, Sergey Tarima, John R. Meurer, David Friedland, Ndidiamaka Ojiako, Michael Anello, David Zimmerman, Renee Mccoy, Reza Shaker

Biostatistics Faculty Publications

Introduction: The study objective was to evaluate whether the formation and funding of team science-guided Integrated Clinical Research Ensembles (ICREs) enhance individual faculty productivity, measured by publication and impact factor adjusted citation rates. The setting was a multi-institutional NIH Clinical and Translational Science Award-supported hub. Methods: Monthly faculty publication and impact factor adjusted citation rates were analyzed using data extracted from the hub-managed Faculty Collaboration Database (FCD). The FCD imports indexed publications for all faculty members across four academic institutions, drawing from PubMed and faculty curriculum vitae. Monthly publication counts were modeled using Poisson regression, fitted using generalized estimating equations …

Approved Programs 9-2-25, Angela Brock

Programs Committee (PC)

No abstract provided.

Program Agenda 9-2-25, Angela Brock

Programs Committee (PC)

No abstract provided.

Examining The Role Of The M1 Motif Of Abcr1 Srna In Agrobacterium Tumefaciens, Daniel Arango-Cardona

Theses and Dissertations

Agrobacterium tumefaciens is a gram-negative alphaproteobacterium that is one of the causative agents of crown gall tumors on plants. Its ability to transform plants using its T-DNA has been studied to improve plant-mediated transformation. sRNAs are small regulatory RNAs that play a role in gene expression in a variety of organisms and bind to target proteins or mRNAs. A. tumefaciens contains two sibling sRNAs, called AbcR1 and AbcR2, which are conserved among alphaproteobacteria. A. tumefaciens AbcR1 and AbcR2 are closely related, exhibiting 69% sequence identity, similar secondary and tertiary structure, and a conserved motif, M2, believed to direct target interactions. …

09.02.2025 Ored Connect, Liz Williamson

ORED Newsletter

• NIH Specific Aims Statement RED Talk
• NSF Research Security Training 

Magnetic Nanoparticles Tethered With Zn–Dpa For The Removal Of Bacteria From Red Blood Cell Suspension, Tochukwu P. Okonkwo, Rajendra P. Gautam, Jacob B. Limburg, Breckin L. Forstrom, Bowen J. Houser, Aaron Rappleyea, Tyler P. Green, Joseph P. Talley, Alexander D. Daum, Stacey J. Smith, Karine Chesnel, William G. Pitt, Roger G. Harrison

Faculty Publications

Bacterial infections continue to drive the need for more effective and rapid methods for bacterial analysis. To address this, magnetic nanoparticles (MNPs) have emerged as promising tools, especially when their surfaces are modified with bacteria binders. The bis-zinc–dipicolylamine (Zn–DPA) complex is known for its broad affinity to bacteria. We have synthesized MNPs via a thermal decomposition method, encapsulated them in silica, modified their surface with Zn–DPA, and tested their ability to remove bacteria. The MNPs retain their superparamagnetic properties and crystallite structure after being encapsulated. The MNPs coated with silica and Zn–DPA effectively bind and remove both Gram-positive and Gram-negative …

Chapter 9 Bankruptcy: The Solution That Causes Problems, Peter C. Alexander

Brooklyn Journal of Corporate, Financial & Commercial Law

There is a little-known form of bankruptcy called a “Chapter 9,” reserved for insolvent cities, villages, and other municipalities. Occasionally, one reads about a city or a county that has filed for Chapter 9 relief, like Detroit, Michigan, or Orange County, California; however, it is very hard to file a Chapter 9 case, in part, because existing law requires a municipality to obtain permission from its home state before it can file for relief in the U.S. Bankruptcy Court. An additional constraint is that the only option municipalities have when seeking bankruptcy relief is to file a Chapter 9 because …

Wine Unwelcome: The Constitutional Contours Of Wine Regulation, Alexander Fallone

Brooklyn Journal of Corporate, Financial & Commercial Law

Wine retail shops face a dizzying labyrinth of state laws that severely restrict their ability to ship wine to out-of-state consumers. While the dormant Commerce Clause would normally strike down laws that impose restrictions on interstate commerce, wine (and alcoholic beverages) must contend with Section Two of the Twenty-first Amendment, which gives the states control over the importation and distribution of wine intending to be consumed within their borders. Court of Appeals cases interpreting Supreme Court precedent on the tension between the dormant Commerce Clause and Section Two have practically stripped the dormant Commerce Clause of any power. This Note …

Factors Contributing To The Demographic Cliff: More U.S. Women Of Childbearing Age, But Fewer Have Given Birth, Kenneth M. Johnson

Carsey Publications

In this brief, author Kenneth Johnson reports that in 2024 there were 5.7 million more childless women of prime child-bearing age than would have been expected given fertility patterns prior to the Great Recession, up from 2.1 million in 2016 and 4.7 million in 2022. There are 4 million more women aged 20–39 than in 2006, but 7 million fewer have given birth. The shift in fertility patterns has resulted in 11.8 million fewer babies in the past 17 years.

Fertility rate declines were greatest among women under 30, where childless rates increased the most. Childless rates increased modestly among …

September 2, 2025

The Gavel Gazette

No abstract provided.

A Pilot Study On Tissue Deformation Using An Integrated Sensor–Actuator Blood Collection Setup In Aquaculture (Salmo Salar), Ishrak Siddiquee, Md Ebne Al Ashad, Ahmed Hasnain Jalal

Electrical and Computer Engineering Faculty Publications

This pilot study presents a sensor–actuator setup designed to evaluate tissue deformation in Atlantic Salmon (Salmo salar) during needle insertion. The system integrates three types of low-cost, commercially available force sensors to capture force profiles and identify biomechanical events associated with tissue layer transitions. Controlled insertions were performed on a deceased specimen, and the resulting force data were analyzed to quantify insertion dynamics and estimate tissue deformation. A simulation model based on the recorded force values was developed to calculate stress distribution and deformation, which ranged from 0.001 µm to 8.4 µm and from 0.3 N/m2 to 4.9 N/m2, respectively. …

Network Meta-Analysis Of Randomized Controlled Trials Comparing Safety And Efficacy Of Pharmacological Treatments In Reducing Pain During Intrauterine Device Insertion, Ahmed Ashour, Ahmed H. Saad, Iman Elzahaby

Sultan Qaboos University Medical Journal

Conflicting evidence exists regarding the effectiveness of pharmacological interventions in reducing pain during intrauterine device (IUD) insertion. This study aimed to evaluate the safety and efficacy of various analgesics and to rank their effectiveness. A total of 71 randomized controlled trials (RCTs) involving 10,870 women were included. Data were sourced from PubMed, Cochrane Library, Scopus, and other databases up to September 2023. Analyses were performed using the Netmeta package in R, with results reported as standardized mean differences (SMDs) and risk ratios (RRs), each with corresponding 95% confidence intervals (CIs). Lidocaine 4% gel (5 mL) emerged as the most effective …

Opting Out: Over-Alerting And Warning Fatigue In The Era Of Wireless Emergency Alerts, Jeannette Sutton, Michele M. Wood

Emergency Preparedness, Homeland Security, and Cybersecurity Faculty Scholarship

While warning fatigue is commonly described among emergency management practitioners as a problem due to over-alerting, which leads to opting out, there has been limited research to define these concepts in a systematic manner that can inform policymaking around public alerting strategies, especially as they relate to Wireless Emergency Alerts (WEA). In this study, we draw from semi-structured interviews with emergency managers and open-ended responses from surveys with emergency managers and members of the public, to develop definitions of “over-alerting” and “warning fatigue” and to identify the conditions that cause the public to “opt out” of WEA messages. We conduct …

Path To Parenthood For Medical Residents And Fellows: The Impact Of Leave Policies On Parent Trainees At Oregon Health And Science University, Eline Lenne, Marie Soller, Gillian Lashen, Stephanie Dukhovny, Alinda Reimer, Susanne Klawetter, Emily Carter

School of Social Work Faculty Publications and Presentations

Residents and fellows in graduate medical education (GME) programs across the USA often complete training during childbearing years, presenting challenges for pregnant and parenting trainees balancing work and family. Institutional policies must better support these trainees. Previous studies show supported trainees experience reduced burnout, better health, and improved patient outcomes.

This study assessed the experiences and unmet needs of pregnant and parenting GME trainees and presents their recommendations for improved support.

Methods: Using a sequential explanatory mixed-methods design, we examined the unmet needs and challenges of pregnant and parenting trainees, and their recommendations for improvement. We distributed a survey to …

Psychopathology: Theory And Assessment, Russell Hall

Syllabi

No abstract provided.

Counseling Internship - Three, Jacqueline Smith

Syllabi

No abstract provided.