Digital Commons Network^™

Cemented Republic: Infrastructure And Slow Violence In Jun Cruz Reyes’S Ang Huling Dalagang Bukid At Ang Authobiography Na Mali: Isang Imbestigasyon, Jonah Leigh E. Ramos

Akda: The Asian Journal of Literature, Culture, Performance

To read the novel is to read history from a vantage point, and to read Jun Cruz Reyes’s metafiction novel, Ang Huling Dalagang Bukid at ang Authobiography na Mali: Isang Imbestigasyon (2011), is to read unaccounted-for experiences of violence in spaces that house the spectacle of national infrastructure. Informed by concepts from environmental humanities and urban studies, this paper explores the intersection of infrastructure and violence in Ang Huling Dalagang Bukid. It interrogates the choice experimental form of the novel, close reads descriptive passages about infrastructure, and highlights corresponding manifestations of slow violence impacting humans and nonhumans alike. The …

Icc Agenda 10-7-25, Angela Brock

Individual Course Committee (ICC)

No abstract provided.

Ucc Minutes 10-7-25, Angela Brock

UCC Agendas/Minutes

No abstract provided.

Functional Diversity In Gii.4 Norovirus Entry: Hbga Binding And Capsid Clustering Dynamics, B Vijayalakshmi Ayyar, Carmen V Apostol, Janam Jitendra Dave, Soni Kaundal, Joseph A Kendra, Frederick H Neill, Khalil Ettayebi, Sarah Maher, Ramakrishnan Anish, Gabriel I Parra, Göran Larson, Robert L Atmar, Sue E Crawford, B V Venkataram Prasad, Mary K Estes

Faculty, Staff and Students Publications

Human noroviruses (HuNoVs), especially GII.4 strains, are the leading cause of acute viral gastroenteritis worldwide, yet no approved vaccines or antivirals exist. The pandemic GII.4 Sydney 2012 strain enters cells via membrane wounding and clathrin-independent carrier-mediated endocytosis, but it is unclear whether this entry mechanism is conserved across GII.4 variants. We compared early binding and entry of multiple GII.4 variants using wild-type and mutant GII.4 virus-like particles (VLPs) and modified human intestinal enteroid cultures. Only a subset of GII.4 variants, including GII.4 Sydney, form distinct, histo-blood group antigen (HBGA)-dependent capsid clusters on the cell surface. Clustering strains display significantly enhanced …

Social Media, Social Sensibilities, And The Employment Relationship, Matthew W. Finkin

The Journal of Contemporary Legal Issues

Employers have long made decisions based on the applicant’s or incumbent employee’s respectability. Those whose transgress the bounds could be excluded; e.g., those who publicly embrace the Ku Klux Klan.[] In other words, frank speech—speech “unconstrained by anything that might normally encourage one to be more circumspect,”[] speech revealing one’s “true feelings, however repellant to popular morality”[]—is not invariably a good thing.[]

When social media came into wide use, employers extended their monitoring of applicants and incumbents for the acceptability of that speech.[] There is nothing new in that.[] In the absence of a clear direction embodied in law …

When Is Free Speech “Beyond” The Constitution?, Abner S. Greene

The Journal of Contemporary Legal Issues

The constitution of a nation without a state action doctrine might limit private restriction or compulsion of speech just as it limits the state. In such a nation, “free speech beyond the constitution” might not be a particularly meaningful concept. In the United States, however, the First Amendment’s free speech clause limits only what the federal, state, and local governments may do. As a nonconstitutional policy matter, it might or might not be a good idea for the government to impose First Amendment- like restrictions on private actors or for private actors to voluntarily impose First Amendment-like restrictions on themselves. …

Hear Me Out: What Is Our Obligation To Listen?, Thomas Healy

The Journal of Contemporary Legal Issues

Most scholarly discussions about “cancel culture” focus on the extent to which imposing economic or social sanctions on speakers violates the principle of free speech. In this essay, I consider a related question, which is whether deliberately avoiding, ignoring, or blocking speakers one disagrees with is antithetical to free speech. Although it might seem strange to suggest that a principle concerned with the right to speak entails an obligation to listen, I argue that genuine “good faith” listening is necessary to further the goals free speech is designed to serve. However, I also argue that this obligation is imperfect, or …

Genetics-Nutrition Interactions Control Diurnal Enhancer-Promoter Dynamics And Liver Lipid Metabolism, Dishu Zhou, Ying Chen, Panpan Liu, Kun Zhu, Juliet Holder-Haynes, S Julie-Ann Lloyd, Cam Mong La, Inna I Astapova, Seunghee Choa, Ying Xiong, Hosung Bae, Marlene Aguilar, Hongyuan Yang, Yu A An, Zheng Sun, Mark A Herman, Xia Gao, Liming Pei, Cholsoon Jang, Joshua D Rabinowitz, Samer G Mattar, Yongyou Zhang, Dongyin Guan

Faculty, Staff and Student Publications

The circadian clock controls 24-h rhythmic processes. However, how genetic variations outside clock genes impact peripheral diurnal rhythms remains largely unknown. Here, we find that genetic variation contributes to different diurnal patterns of hepatic gene expression in both humans and mice. Nutritional challenges alter the rhythmicity of gene expression in mouse liver in a strain-specific manner. Remarkably, genetics and nutrition interdependently control more than 80% of rhythmic gene and enhancer-promoter interactions (E-PIs), with a noncanonical clock regulator, estrogen-related receptor gamma (ESRRγ), emerging as a top transcription factor during motif mining. Knockout of Esrrγ abolishes strain-specific metabolic processes in response to …

The Latest In Resuscitation Research: Highlights From The 2024 American Heart Association's Resuscitation Science Symposium, Gabriela M Galli, Aarthi Kaviyarasu, Sachin Agarwal, Catherine R Counts, Tommaso Scquizzato, Betty Yang, Clark G Owyang, Ryan Coute, Simon Orlob, Lindsay Shepard, Saleem Halablab, James Horowitz, Sarah Perman, Ryan Morgan, Anne Grossestreuer, Jacob Vine, Nicholas Johnson, Luke Andrea, Ari Moskowitz, Benjamin Abella, Cameron Dezfulian, Walid H Farooqi, Felipe Teran

Faculty, Staff and Students Publications

No abstract provided.

Impact Of Obicetrapib On Major Adverse Cardiovascular Events In High-Risk Patients: A Pooled Analysis, Stephen J Nicholls, Adam J Nelson, Kausik K Ray, Christie M Ballantyne, Marc Ditmarsch, Douglas Kling, Andrew Hsieh, Michael Szarek, John J Kastelein, Michael H Davidson

Faculty, Staff and Students Publications

Background: The cholesteryl ester transfer protein inhibitor obicetrapib decreases levels of atherogenic lipids and raises high-density lipoprotein cholesterol (HDL-C).

Objectives: In this study, we sought to determine the effect of obicetrapib on cardiovascular events.

Methods: The effects of 10 mg obicetrapib and placebo daily on major adverse cardiovascular event (MACE) rates were investigated in a pooled analysis of 354 patients with heterozygous familial hypercholesterolemia (HeFH) and 2,530 patients with atherosclerotic cardiovascular disease (ASCVD) over 365 days. The association between on-treatment lipids and MACE were also investigated.

Results: The cohort (mean age 66 years, 36% female, ASCVD 82%, HeFH 27%, diabetes …

Efficacy Of Erdafitinib Before Or After Enfortumab Vedotin In Fgfr3-Altered Advanced Urothelial Cancer: Analysis Of The Unite Collaborative Study, Cindy Y Jiang, Hyunsoo Hwang, Ilana Y Epstein, Dimitra Rafailia Bakaloudi, Rafee Talukder, Amy K Taylor, Amanda Nizam, Tanya Jindal, Michael J Glover, Ali Raza Khaki, Pedro C Barata, Charles B Nguyen, Eugene Oh, Nancy B Davis, Hannah Mabey, Christopher J Hoimes, Sean T Evans, Bashar Abuqayas, Emily Lemke, Irene Tsung, Wei Qiao, Deepak Kilari, Yousef Zakharia, Mehmet A Bilen, Matthew I Milowsky, Sumit A Shah, Shilpa Gupta, Hamid Emamekhoo, Joaquim Bellmunt, Ajjai S Alva, Petros Grivas, Pavlos Msaouel, Vadim S Koshkin, Matthew T Campbell, Omar Alhalabi

Faculty, Staff and Students Publications

Background: Erdafitinib is approved for locally advanced/metastatic urothelial cancer (LA/mUC). As enfortumab vedotin (EV) plus pembrolizumab enters frontline management, outcomes with erdafitinib pre- and post-EV are clinically relevant but not specifically evaluated in clinical trials.

Methods: UNITE is a multi-institutional retrospective study of patients with LA/mUC treated with novel targeted agents. All patients with FGFR3 alterations treated with EV only, erdafitinib then EV (Erda->EV), and EV then erdafitinib (EV->Erda) were included. Sequential treatment with EV and Erda was not required. Primary endpoints were observed response rates (ORR) and progression-free survival (PFS); secondary endpoint was overall survival (OS).

Results: …

Phosphorylation Of Ryr1 At Ser2902 Decreases Ca2+ Leak In Skeletal Muscle And Susceptibility To Malignant Hyperthermia And Heat Stroke, Rachel Sue Zhen Yee, Chang Seok Lee, Ting Chang, Sung Yun Jung, Omar Yousif, Courtney Cavazos, John Colyer, Filip Van Petegem, George G Rodney, Susan L Hamilton

Faculty, Staff and Students Publications

The ryanodine receptor 1 (RYR1) is the sarcoplasmic reticulum (SR) Ca2+ release channel required for both skeletal muscle contraction and Ca2+ leak. Mutations in RYR1 cause malignant hyperthermia susceptibility (MHS) and enhanced sensitivity to heat stroke (ESHS), which can result in death due to excessive skeletal muscle thermogenesis upon exposure to volatile anesthetics or heat. Here, we investigated the molecular and physiological functions of phosphorylation of RYR1 at Ser2902 by the kinase SPEG (striated muscle preferentially expressed protein). Muscle from SPEG-deficient mice expressing RYR1 with a Ser2902 →Asp2902 (S2902D) point mutation to mimic phosphorylation by SPEG showed decreased SR Ca2+ …

Biliverdin Reductase A Is A Major Determinant Of Protective Nrf2 Signaling, Chirag Vasavda, Ruchita Kothari, Navneet Ammal Kaidery, Suwarna Chakraborty, Sunil Jamuna Tripathi, Ryan S Dhindsa, Cristina Ricco, Shruthi Shanmukha, Samaneh Saberi, Julia E Lefler, Priyanka Kothari, Kalyani Chaubey, Adele M Snowman, Michael C Ostrowski, Eugenio Barone, Lakshminarayan M Iyer, L Aravind, Sudarshana M Sharma, Andrew A Pieper, Bobby Thomas, Solomon H Snyder, Bindu D Paul

Duncan NRI Faculty and Staff Publications

Biliverdin reductase A (BVRA), the terminal enzyme in heme catabolism, generates the neuroprotective and lipophilic antioxidant bilirubin. Here, we identify a nonenzymatic role for BVRA in redox regulation. Through phylogenetic, genetic, biochemical, and enzymatic assays, we found that BVRA exerts critical nonenzymatic antioxidant activity. Transcriptomic analyses further revealed that BVRA physically and genetically interacts with nuclear factor erythroid-derived factor-like 2 (NRF2), a major transcriptional regulator of cellular redox signaling. ChIP-seq and RNA-seq analyses reveal that BVRA and NRF2 coordinate the expression of antioxidant genes, many of which are typically dysregulated in neurodegenerative conditions such as Alzheimer's disease. Thus, this noncanonical …

Fiber Recruitment Drives A Phase Transition Of Cell Polarization At A Critical Cell Spacing In Matrix-Mediated Tissue Remodeling, Xiangjun Peng, Yuxuan Huang, Wenyu Kong, Yanan Du, Elliot L Elson, Xi-Qiao Feng, Guy M Genin

2020-Current year OA Pubs

Biological tissues exhibit sharp phase transitions where cells collectively transition from disordered to ordered states at critical densities. We demonstrate through bio-chemo-mechanical modeling that this emergent behavior arises from a nonmonotonic dependence on nonlinear extracellular matrix (ECM) mechanics: mechanical communication between cells is optimized at intermediate stiffness values where cells can both generate sufficient forces and create strain-stiffened tension bands in the ECM. This balance establishes a critical cell spacing threshold for cell-cell communication ([Formula: see text]100 to 200 [Formula: see text]m) that is conserved across experimental observations for a broad range of cell types and collagen densities. Our model …

Re: Butte Priority Soil Operable Unit (Bpsou) Final Bres No. 35 Del Monte Reclamation Improvement Field Sampling Plan, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Methemoglobinemia-Induced Cardiac Dysfunction In A Pediatric Patient, Brian Drury, Chelsea Boyd, Kelsey Van Housen, Siraj Amanullah

Student Papers, Posters & Projects

Methemoglobinemia is a rare congenital or acquired cause of functional anemia resulting from oxidation of hemoglobin. Prompt recognition and treatment are critical to prevent tissue hypoxia and end-organ injury. While other complications are well described, cardiac dysfunction is rarely reported—especially in children. We present what, to our knowledge, is the first known case of methemoglobinemia-induced transient cardiac dysfunction—or “myocardial stunning— in a pediatric patient. This case underscores the importance of maintaining a high index of suspicion and assessing cardiac involvement in such patients. Early intervention can lead to full recovery and prevent long-term sequelae, even in the presence of multiorgan …

Scientific Authority In The Public Sphere: The Heroic Legacies Of Carl Sagan And Philip Zimbardo, Scott T. Allison

Heroism Science

This article examines the parallel trajectories of Carl Sagan and Philip Zimbardo as scientists who assumed the role of public intellectuals. Their careers highlighted the tensions and opportunities inherent in bridging scholarly research and public engagement. Sagan, an astronomer, popularized the cosmic perspective to promote planetary stewardship, while Zimbardo, a social psychologist, used compelling methodologies to explore the psychological underpinnings of cruelty and heroism. Both were, in their own ways, heroic in their commitment to making science accessible, employing storytelling and mass media to render complex concepts understandable and relevant, thereby expanding the societal relevance of their disciplines. However, their …

Wearable Single-Channel Electroencephalography, Brain Activity, And Putting Performance In Collegiate Golfers, Pradeep Vanguri, Savannah Calleja, Valerie G. Starratt, Marissa Bonsangue

Journal for Sports Neuroscience

Wearable Electroencephalography (EEG) is a noninvasive method for assessing brain activity. Outside of the context of a traditional medical or laboratory setting, this technology may provide insight into the study of brain activity during activity or sport. In golf, for example, similar research revealed associations in skilled golfers between activity in the alpha brain wave and conscious control of motor activity during putting. The purpose of this research was to further investigate the association between brain-wave activity and athlete performance using a wearable single-channel EEG device during putting in collegiate golfers. Male and Female golfers (n = 11) from …

Revisiting Least Restrictive Environment In Adapted Physical Education: A Framework For Evidence-Based Practice, Dillon R. Martinez, Samantha Charron

Essays in Education

This article addresses the implementation of Least Restrictive Environment (LRE) principles in adapted physical education. Despite the legal mandates established by the Individuals with Disabilities Education Act, the field faces significant challenges, including a shortage of qualified professionals, overemphasis on universal inclusion, and the exclusion of student voices from placement decisions. Through analysis of historical context, implementation challenges, and a proposed Student-Centered APE Placement Model (SCAPM), this article provides a preliminary framework for making evidence-based placement decisions that prioritize student success. By integrating perspectives from a preservice teacher education candidate and current higher education practice, the framework offers practitioners a …

Revisiting “Autobiographical Reflections: My Story”: A Reflection On The Unspoken And Misconveyed, Ronak Karami

Journal of International Women's Studies

This piece revisits and reflects on my feminist essay, “Autobiographical Reflections: My Story” (2020), published in the Journal of International Women's Studies. With the benefit of years of growth and introspection, I return to that work and see more than the story I once told. I now notice the silences between the lines, the nuances I overlooked, and the unintended messages my words may have carried. This reflection is not an attempt to erase my truth but rather an effort to revisit and refine it—to provide, within the confines of a few pages, greater clarity, accountability, and context where …

Evaluating Gender Policy In Kazakhstan: A Dual Perspective On Politics And Economics, Elmira Kagazbaeva, Ulzhan Kazybekova, Madina Axakalova

Journal of International Women's Studies

This article aims to advance gender studies in Kazakhstan by examining the underlying causes of inequality in the political and economic spheres. It holds both scientific and practical significance in identifying the challenges to gender equality in Kazakhstan and exploring potential solutions that could be applicable to other countries. The methodological framework of the study is grounded in a gender-based approach, complemented by general scientific and specialized methods of inquiry, including structural, functional, and content analysis of official documents. The research is supported by an analysis of official statistics and the legal framework governing gender-related issues. Kazakhstan’s gender policy is …

Antecedents And Measures Of Women’S Financial Empowerment: A Comprehensive And Global Literature Review, Priya Gupta, Mamta Aggarwal, Meera Bamba

Journal of International Women's Studies

Women’s financial empowerment has garnered greater interest in recent years, and numerous articles have highlighted gender disparities. In existing literature, antecedents and measures of economic empowerment are fragmented, with limited research that provides a comprehensive assessment framework. This systematic review aims to identify the determinants affecting women’s financial empowerment to develop a comprehensive framework to measure financial empowerment based on insights derived from an examination of 101 selected research articles published from 2001 to 2023 and exclusively sourced from the Scopus database. The search followed a comprehensive and systematic approach involving identification, selection, appraisal, and synthesis of the existing literature. …

Undoing Gender Performativities In Nawal El Saadawi’S Woman At Point Zero, Tobe Levin Von Gleichen, U. H. Ruhina Jesmin, Tasnuva Khair

Journal of International Women's Studies

Physician, psychiatrist, and Marxist activist for women’s rights, Nawal El Saadawi (1931-2021) published fiction and non-fiction exposing how a capitalistic, phallocratic social order keeps Egyptian women in thrall to men through violent suppression. Women are exploited by men, who see women as weak and prey on these presumed docile subordinates in a display of masculinity. Deciphering the effects of this gendered performativity through the lens of Judith Butler, El Saadawi’s novel Woman at Point Zero (1977/2015a), or Ferdaous, une Voix en Enfer (El Saadawi, 1977/2007) in French, provides a narrative whose significance is amplified by Butlerian theory. The protagonist, …

Keys For Success When Using An Integrative Interprofessional Teaching Model: A Synergistic Approach, Hon-Vu Quang Duong, Nina Marcellus, Sandip Thanki

Journal of Educational Research and Practice

This study presents a longitudinal analysis of the qualitative experiences and quantitative outcomes associated with integrative, interdisciplinary teaching in the context of a specific nursing course, Pathophysiology (NURS 337), at a public, 4-year, state college (now university). Spanning an 8-year period, from 2014–2022, the research compares two distinct student cohorts: one exposed to collaborative interdisciplinary teaching methods, the other to traditional non-collaborative instructional approaches. The findings reveal that integrative, interdisciplinary teaching yielded significant benefits across multiple metrics. Notably, integrative, interdisciplinary teaching contributed to a more normalized distribution of grades, higher student retention rates, and an elevated cumulative GPA at the …

Positive Education And Student Success In College: An Overview And Practical Implications, Lin L. Agler, Saurabh Gupta

Journal of Educational Research and Practice

Institutions of higher education are facing a historically challenging time as student graduation and retention rates continue to be less than ideal, especially since the start of the COVID-19 pandemic. This is a critical time of transition for the competitive structure of higher learning, as finances, technology, student success, and institutional rankings all have a joint leading position in this structure. Applying concepts of positive psychology to higher education has been shown to be advantageous for student success and retention. This strengths-based approach helps institutions remain innovative and competitive. However, instructors face a great challenge in effectively applying positive psychology …

A Proposed Model For Parental Partnership In Developing The Life Skills Of A Kindergarten Child In Light Of Reggio Emilia Approach, Manar Soud Alotaibi

University of Bisha Journal for Educational Sciences

The aim of the research is to shed light on the importance of developing the life skills of a kindergarten child, to identify the life skills that must be developed at this stage, and the importance of parental Involvement in developing these skills, to study and analyze the appropriateness of the Reggio Emilia approach to help the parents of a kindergarten child to partner in developing the life skills of their child, to identify the obstacles that limit the parents' involvement in developing the life skills of their child, and to present a proposed model to activate the parental involvement …

Double-Cone Spiralling Model: Integrating Ancestral Elements And Future Possibilities In Service Design, Zijun Lin, Riccardo Torta, Beatrice Villari

ServDes Conference Series

As an interdisciplinary approach, service design (SD) has integrated multidisciplinary perspectives to extend its capability and reinforce its transformative role in addressing service (eco)system transformations. However, as both external and internal ecosystem dynamics introduce growing complexity and uncertainty, SD must continue to evolve its frameworks. This paper proposes a double-cone spiralling interpretive model for SD, outlining a potential spiralling trajectory of system transformation by bridging ancestral elements with future possibilities. The interpretive model draws on emerging SD frameworks that integrate transdisciplinary knowledge and case study analyses of illustrative examples. It highlights the importance of systemically considering ancestrality, long-term temporality, and …

Empowering Rural Women Of Olasahi: Service Blueprint For A Community-Driven Sustainable Revenue Model, Gatikrushna Mohapatra, Seema Krishnakumar

ServDes Conference Series

This research paper explores the development of a sustainable business model for rural women in Olasahi, Jajpur, Odisha. Women in this region primarily engage in traditional snack-making but lack access to structured markets, have limited sources of revenue, and have limited financial awareness. The study integrates service design principles with entrepreneurship models to create a sustainable revenue framework enabling financial independence. A mixed-methods approach was employed, including surveys, focus group discussions, and case study analyses. The study highlights key barriers such as limited financial literacy, market inaccessibility, and a lack of structured business knowledge. It also identifies scalable solutions inspired …

Affordable Housing Using Bamboo: A Community-Driven Service Design Inquiry Using Creative What-If Exercises, Rajarshi Ray, Parthasarathi Mukhopadhyay

ServDes Conference Series

Affordable Housing (AH) remains a critical global issue, especially for economically weaker sections (EWS) of the developing countries like India. Non-affordability of typical building materials, make the EWS choose alternate materials like bamboo, which is traditionally-used in the tropics for being sustainable and affordable. However, challenges related to standardisation and societal perception hinder its mainstreaming. This warrants a holistic design approach like Service Design (SD), connecting different stakeholders involved with AH using bamboo, at the system level. While SD has wide application across different sectors, its role in building industry, remains relatively underexplored. Subsequently, four community-driven Indian initiatives are studied …

Invisible Hands, Indispensable Work: Human Centered Systemic Insights Into India’S Informal Service Of Domestic Work, Rahul Satish Mudukutore, Suprita Chaudhary, Debjani Roy, Veda Shetye, Mallika Kayastha

ServDes Conference Series

Domestic work in India constitutes a vast yet unregulated sector. This study employs a service centric approach to explore the systemic challenges faced by domestic workers. Through a mixed - methods approach including in - depth interviews, surveys, ethnographic studies, and service design analysis, we uncover key findings related to employment precarity, employer - worker power dynamics, and the informal nature of hiring practices. Our research highlights critical gaps in legal protections, lack of standardized employment contracts, and the socio - cultural barriers reinforcing domestic work as undervalued labour. Using stakeholder mapping, ecosystem analysis, and service blueprints, we identify intervention …