Digital Commons Network^™

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.

Positron Emission Tomography Reveals Increased Myocardial Glucose Uptake In A Subset Of Friedreich Ataxia Patients, R Mark Payne, Thomas M O'Connell, P Melanie Pride, Gregg R Wagner, George J Eckert, Tiffany R Johnson, Weinian Shou, Gary D Hutchins

Faculty, Staff and Student Publications

Why some but not all patients with the rare disease Friedreich ataxia (FRDA) are at increased risk of poor cardiovascular outcome and death is unclear and unpredictable. We investigated the hypothesis that mitochondrial dysfunction in FRDA leads to altered patterns of myocardial metabolic substrate utilization. We recruited 5 healthy controls (Ctl) and 11 FRDA participants. All underwent fasting myocardial positron emission tomography (PET scan) with 15O–H2O, 18F-FDG, and 11C-Palmitate. We conducted cardiac transcriptomics on mice with ablation of the Frda gene in heart to explore mechanisms of fuel substrate utilization. Five (45%) FRDA participants had an LV mass index (LVMi) …

Transdiagnostic Alterations In White Matter Microstructure Associated With Suicidal Thoughts And Behaviours In The Enigma Suicidal Thoughts And Behaviours Consortium, Laura S Van Velzen, Lejla Colic, Zuriel Ceja, Maria R Dauvermann, Luca M Villa, Hannah S Savage, Yara J Toenders, Niousha Dehestani, Alyssa H Zhu, Adrian I Campos, Lauren E Salminen, Martin Alda, Ingrid Agartz, Nina Alexander, Rosa Ayesa-Arriola, Elizabeth D Ballard, Nerisa Banaj, Carlotta Barkhau, Zeynep Başgöze, Jochen Bauer, Francesco Benedetti, Klaus Berger, Bianca Besteher, Katharina Brosch, Manuel Canal-Rivero, Simon Cervenka, Romain Colle, Colm G Connolly, Emmanuelle Corruble, Philippe Courtet, Baptiste Couvy-Duchesne, Benedicto Crespo-Facorro, Kathryn R Cullen, Udo Dannlowski, Jeremy Deverdun, Ana M Diaz-Zuluaga, Lorielle M F Dietze, Jennifer W Evans, Negar Fani, Kira Flinkenflügel, Naomi P Friedman, Ian H Gotlib, Nynke A Groenewold, Dominik Grotegerd, Tomas Hajek, Alexander S Hatoum, Marco Hermesdorf, Ian B Hickie, Yoshiyuki Hirano, Tiffany C Ho, Yuki Ikemizu, Frank Iorfino, Jonathan C Ipser, Yuko Isobe, Andrea P Jackowski, Fabrice Jollant, Tilo Kircher, Melissa Klug, Sheri-Michelle Koopowitz, Anna Kraus, Axel Krug, Emmanuelle Le Bars, Elisabeth J Leehr, Meng Li, Elizabeth T C Lippard, Carlos Lopez-Jaramillo, Ivan I Maximov, Andrew M Mcintosh, Katie A Mclaughlin, Sean R Mcwhinney, Susanne Meinert, Elisa Melloni, Philip B Mitchell, Benson Mwangi, Igor Nenadić, Stener Nerland, Emilie Olie, Victor Ortiz-García De La Foz, Pedro M Pan, Fabricio Pereira, Fabrizio Piras, Federica Piras, Sara Poletti, Andrew E Reineberg, Gloria Roberts, Rafael Romero-García, Matthew D Sacchet, Giovanni A Salum, Anca-Larisa Sandu, Carl M Sellgren, Eiji Shimizu, Harry R Smolker, Jair C Soares, J Douglas Steele, Frederike Stein, Dan J Stein, Benjamin Straube, Lea Teutenberg, Florian Thomas-Odenthal, Paula Usemann, Romain Valabregue, Johanna Valencia-Echeverry, Gerd Wagner, Gordon Waiter, Martin Walter, Heather C Whalley, Mon-Ju Wu, Tony T Yang, Carlos A Zarate, Andre Zugman, Giovana B Zunta-Soares, Kees Van Heeringen, Sanne J H Van Rooij, Nic Van Der Wee, Steven Van Der Werff, Paul M Thompson, Hilary P Blumberg, Anne-Laura Van Harmelen, Miguel E Rentería, Neda Jahanshad, Enigma Suicidal Thoughts And Behaviours Consortium, Lianne Schmaal

Faculty, Staff and Student Publications

Previous studies have suggested that alterations in white matter (WM) microstructure are implicated in suicidal thoughts and behaviours (STBs). However, findings of diffusion tensor imaging (DTI) studies have been inconsistent. In this large-scale mega-analysis conducted by the ENIGMA Suicidal Thoughts and Behaviours (ENIGMA-STB) consortium, we examined WM alterations associated with STBs. Data processing was standardised across sites, and resulting WM microstructure measures (fractional anisotropy (FA), axial diffusivity (AD), mean diffusivity and radial diffusivity) for 24 WM tracts and one global measure were pooled across 40 cohorts. We compared these measures among individuals with a psychiatric diagnosis and lifetime history of …

Distinct Spatiotemporal Patterns Of White Matter Hyperintensity Progression, Jinyong Chung, Gilsoon Park, Wi-Sun Ryu, Dawid Schellingerhout, Hang-Rai Kim, Dong-Seok Gwak, Elizabeth Haddad, Neda Jahanshad, Beom Joon Kim, Keun-Sik Hong, Hyerin Oh, Sang-Wuk Jeong, Joon-Tae Kim, Man Seok Park, Kang-Ho Choi, Kyungbok Lee, Tai Hwan Park, Sang-Soon Park, Jong-Moo Park, Kyusik Kang, Kyung-Ho Yu, Mi Sun Oh, Soo Joo Lee, Jae Guk Kim, Jae-Kwan Cha, Dae-Hyun Kim, Jun Lee, Moon-Ku Han, Yong-Jin Cho, Byung-Chul Lee, Philip M Bath, Joanna M Wardlaw, Hee-Joon Bae, Hosung Kim, Dong-Eog Kim

Faculty, Staff and Student Publications

White matter hyperintensity, a key imaging biomarker for brain health, has prognostic implications for stroke. Using a multicenter MRI dataset of 9179 stroke patients plus the UK Biobank (n = 36,210 low/high risk controls), we employ Subtype and Stage Inference modeling and identify three distinct white matter hyperintensity progression subtypes: fronto-parietal, radial, and temporo-occipital. Longitudinal validation confirms classification stability. The fronto-parietal subtype shows delayed onset and more hypertension, while the temporo-occipital subtype has more atrial fibrillation and coronary heart disease. The fronto-parietal and radial subtypes are linked to small vessel stroke, while the temporo-occipital subtype is linked to cardioembolism. The …

Leptin As A Key Driver For Organ Fibrogenesis, Xue-Nan Sun, Shiuhwei Chen, Shangang Zhao, Jan-Bernd Funcke, Megan Virostek, Line Pedersen, Chao Li, Chanmin Joung, Qian Lin, Yan Li, Ayanna Cobb, May-Yun Wang, Kyounghee Min, Lisandro Maya-Ramos, Giovanna Degasperi, Junquan Liu, Ningyan Zhang, Zhiqiang An, Diana R Tomchick, R Max Wynn, Da Young Oh, Philipp E Scherer

Faculty, Staff and Student Publications

Leptin, a hormone primarily secreted by adipocytes, regulates energy balance and systemic metabolism through its interaction with the leptin receptor (LEPR). Beyond these functions, leptin signaling has been implicated in the pathogenesis of tissue fibrosis. Here, we report the x-ray crystal structures of a leptin-neutralizing antibody (hLep3) in the unbound and leptin-bound states. The interaction of this antibody with leptin mimics the interaction of the LEPR with leptin, providing direct insights into the mechanism by which the antibody disrupts leptin signaling. We furthermore evaluate the therapeutic potential of neutralizing leptin with this antibody across distinct mouse models of fibrosis affecting …

Occ (Non-Sex Abuse) Committee Letter Objecting To Settlement Allocation Of Property

Catholic Dioceses in Bankruptcy

No abstract provided.

Re: Letter Response To Butte Priority Soils Operable Unit (Bpsou) Continued Use Of The Approved Surface Water Quality Assurance Project Plan Silver Bow Creek Butte Area Npl Site (Dated September 15, 2025), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

The Prospector, October 24, 2025, Utep Student Publications

The Prospector

No abstract provided.

Parental And Staff Experiences Of Participation In The Report-Bpd Feasibility Study: Insights From An Embedded Qualitative Research, Wisam Muhsen, Ana Guillot-Lozano, Jos M. Latour

School of Nursing and Midwifery

Highlights: What are the main findings? Parents exhibited a clear understanding of the study’s aims and procedures and expressed confidence in its safety, whereas healthcare professionals displayed inconsistent awareness. Both parents and staff valued participation, highlighted emotional and logistical challenges in the neonatal unit environment, and offered practical suggestions to improve future neonatal research engagement. What are the implications of the main findings? Sustained, multi-directional communication is essential to maintain staff engagement and ensure consistent understanding across all research stakeholders. Embedding family-centred, emotionally supportive strategies—such as structured reflective tools and timely feedback—can enhance ethical recruitment, retention, and data quality in …

Teaching The Teachers: Increasing Science-Literacy Integration In K-6 Classrooms, Brittany E. Kiser

Faculty and Staff Publications & Presentations

This session explores the crucial role of integrating hands-on science content within elementary literacy. Presenters will share pre-service teacher work and insights; participants will engage in hands-on activities demonstrating effective science-literacy integration for K-6 classrooms.

Compromised Pressure-Generating Capacity Of Diaphragmatic Muscle And Its Interaction With The Lower Rib Cage At High Lung Volume During Airway Occlusion, Aladin M Boriek, Noralis Rodriguez-Santiago, Sanghyun Kim, Aubri Ford, Shari Wynd, Rolf D Hubmayr

Faculty, Staff and Students Publications

The pressure generating capacity of the diaphragm is generally thought to be compromised at high lung volume either due to loss of curvature or loss of its membrane tension. At a state of hyperinflation during airway occlusion at total lung capacity, the diaphragmatic muscle is forced to contract from an initial shorter length, the zone of apposition narrows, insertional force on the chest wall is reduced and abdominal compliance falls. We hypothesize that these altered mechanical conditions at high lung volume lead to a loss of the pressure generating capacity that is mediated by excessive muscle shortening rather than loss …

Whole-Genome Sequencing Reveals Individual And Cohort Level Insights Into Chromosome 9p Syndromes, Yingxi Wang, Eleanor I Sams, Rachel Slaugh, Sandra Crocker, Emily Cordova Hurtado, Sophia Tracy, Ying-Chen Claire Hou, Christopher Markovic, Kostandin Valle, Victoria Tate, Khadija Belhassan, Elizabeth Appelbaum, Titilope Akinwe, Rodrigo T Starosta, Yang Cao, Amber Neilson, Yu Liu, Nathaniel Jensen, Reza Ghasemi, Tina Lindsay, Juana Manuel, Sophia Couteranis, Milinn Kremitzki, Jack Ustanik, Thomas Antonacci, Jeffrey K Ng, Andrew Emory, Laura Metz, Tracie Deluca, Katherine N Lyons, Toni Sinnwell, Brianne Thomeczek, Kymme Wang, Nick Sisneros, Megha Muraleedharan, Anantha Kethireddy, Marco Corbo, Harsha Gowda, Katherine A King, Christina A Gurnett, Susan K Dutcher, Catherine Gooch, Yang E Li, Matthew W Mitchell, Kevin A Peterson, Amjad Horani, Jill A Rosenfeld, Weimin Bi, Pawel Stankiewicz, Hsiao-Tuan Chao, Jennifer E Posey, Christopher M Grochowski, Zain Dardas, Erik G Puffenberger, Christopher E Pearson, Frank Kooy, Dale Annear, A Micheil Innes, Michael Heinz, Richard Head, Robert Fulton, Stephan Toutain, 9p-Arch, Lucinda Antonacci-Fulton, Xiaoxia Cui, Robi D Mitra, F Sessions Cole, Julie Neidich, Patricia I Dickson, Jeffrey Milbrandt, Tychele N Turner

Faculty, Staff and Students Publications

Background: Previous genomic efforts on chromosome 9p deletion and duplication syndromes have utilized low-resolution strategies (i.e., karyotypes, chromosome microarrays). These studies have provided important initial insights into these syndromes. This current study is the first large-scale whole-genome sequencing (WGS) study of 100 individuals from families with chromosome 9p syndromes.

Methods: Through the newly formed 9P-ARCH (Advanced Research in Chromosomal Health: Genomic, Phenotypic, and Functional Aspects of 9p-Related syndromes) research network, we assembled a cohort of individuals from families with chromosome 9p syndromes. WGS was applied to 100 individuals, and other genomic technologies were applied to a subset of individuals. To …

Racial Disparities In Clonal Hematopoiesis And Their Impact On Hematologic Malignancies, Zijian Zhang, Chao Cheng

Faculty, Staff and Students Publications

Clonal hematopoiesis of indeterminate potential (CHIP) is a known risk factor for hematologic malignancies (HM), but its distribution and clinical implications across diverse ancestries remain poorly characterized. In this study, we investigated CHIP and its progression to HM in a large, racially diverse cohort from the All of Us Research Program, comprising 245,388 participants. We identified 10,446 CHIP driver mutations in 9,476 individuals. Our analysis revealed clear racial disparities in CHIP prevalence and mutational profiles: African American (AA) individuals had higher odds of CHIP and exhibited distinct mutation patterns compared to White American (WA) individuals. Consistent with prior studies, CHIP …

Lorbin: Efficient Binning Of Long-Read Metagenomes By Multiscale Adaptive Clustering And Evaluation, Wei Xue, Zuo Liu, Yaozhong Zhang, Waseem Raza, Yarong Li, Li Jiang, Ye Tao, Jun Qian, Jousset Alexandre, Fang-Jie Zhao, Yangchun Xu, Fritz Sedlazeck, Qirong Shen, Gaofei Jiang, Zhong Wei

Faculty, Staff and Students Publications

Long-read sequencing has transformed metagenomics and improved the quality of metagenome-assembled genomes (MAGs). However, current binning methods struggle with identifying unknown species and managing imbalanced species distributions. Here, we present LorBin, an unsupervised binner specially designed to reconstruct MAGs in natural microbiomes. LorBin deploys a two-stage multiscale adaptive DBSCAN and BIRCH clustering with evaluation decision models using single-copy genes to maximize MAG recovery. LorBin outperforms six competing binners in both simulated and real microbiomes, including oral, gut, and marine samples. LorBin generated 15-189% more high-quality MAGs with high serendipity and identified 2.4-17 times more novel taxa than state-of-the-art binning methods. …

Whole-Genome Sequencing Reveals Individual And Cohort Level Insights Into Chromosome 9p Syndromes., Yingxi Wang, Eleanor I Sams, Rachel Slaugh, Sandra Crocker, Emily Cordova Hurtado, Sophia Tracy, Ying-Chen Claire Hou, Christopher Markovic, Kostandin Valle, Victoria Tate, Khadija Belhassan, Elizabeth Appelbaum, Titilope Akinwe, Rodrigo T Starosta, Yang Cao, Amber Neilson, Yu Liu, Nathaniel Jensen, Reza Ghasemi, Tina Lindsay, Juana Manuel, Sophia Couteranis, Milinn Kremitzki, Jack Ustanik, Thomas Antonacci, Jeffrey K Ng, Andrew Emory, Laura Metz, Tracie Deluca, Katherine N Lyons, Toni Sinnwell, Brianne Thomeczek, Katherine A King, Christina A Gurnett, Susan K Dutcher, Catherine Gooch, Yang E Li, Amjad Horani, Michael Heinz, Richard Head, Robert Fulton, Lucinda Antonacci-Fulton, Xiaoxia Cui, Robi D Mitra, F Sessions Cole, Julie Neidich, Patricia I Dickson, Jeffrey Milbrandt, Tychele N Turner, Et Al.

2020-Current year OA Pubs

BACKGROUND: Previous genomic efforts on chromosome 9p deletion and duplication syndromes have utilized low-resolution strategies (i.e., karyotypes, chromosome microarrays). These studies have provided important initial insights into these syndromes. This current study is the first large-scale whole-genome sequencing (WGS) study of 100 individuals from families with chromosome 9p syndromes.

METHODS: Through the newly formed 9P-ARCH (Advanced Research in Chromosomal Health: Genomic, Phenotypic, and Functional Aspects of 9p-Related syndromes) research network, we assembled a cohort of individuals from families with chromosome 9p syndromes. WGS was applied to 100 individuals, and other genomic technologies were applied to a subset of individuals. To …

Re: Butte Priority Soils Operable Unit Final Leak Infiltration Evaluation, Josh Bryson

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Revised Draft Final 2022 Insufficiently Reclaimed Sites Sampling: Bres No. 32 – Corra 2 Dump Site Evaluation Summary Report, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Revised Draft Final 2022 Insufficiently Reclaimed Sites Sampling: Bres No. 30 – Atlantic-1 Site Evaluation Summary Report, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Revised Draft Final Butte Priority Soils Operable Unit (Bpsou) Unreclaimed Sites: Ur-08 (Anderson Shaft) Remedial Action Work Plan (Rawp), Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Variables Affecting Extreme Poverty Of Agricultural Sector Households In Indonesia, Syafira Karunia Sari, Nucke Widowati Kusumo Projo

Jurnal Ekonomi dan Studi Pembangunan

This research aims to describe the characteristics of households and the variables that influence extreme poverty in agricultural sector households in Indonesia. This research used the Socio-Economic Survey 2022 with descriptive analysis and binary logistic regression. The results show that 20.78 percent of agricultural sector households are extremely poor. The characteristics of an extremely poor household are: the average number of household members is 5-6 people, the household head is male, the household head is of productive age, lives in a rural area, the maximum education level of the household member is a junior high school/equivalent, more than half of …

Three Generations Under One Roof?: A Study Of Interhousehold Transfers Among Sandwich Generation In Indonesia, Vianey Weda Rahesti, I Dewa Gede Karma Wisana

Jurnal Ekonomi dan Studi Pembangunan

Empirical studies show some negative effects that arise in sandwich generation households. Even the negative impact of the sandwich generation raises the behavior that they want to leave the house. However, the empirical studies only measure sandwich generation if the parents live in the households, so it is necessary to recalculate sandwich generation households in Indonesia through an interhousehold transfer mechanism. This study examines interhousehold transfer differences among sandwich-generation households between parents, siblings, and others in Indonesia. Using the Indonesian Family Life Survey (IFLS) 2014, this study found that 4.539 or 28,6 percent of households are classified as the sandwich …

The Impact Of Corruption And Fiscal Policy On Economic Growth In Asean Countries, Rizki Apriani, Abdul Bashir, Muhammad Subardin

Jurnal Ekonomi dan Studi Pembangunan

This study investigates the impact of government spending, the interaction between corruption and fiscal levels, government debt, and foreign direct investment on economic growth in seven ASEAN countries. Using the World Development Indicators database in the form of time series from the World Bank and the Asian Development Bank for 2000-2021. The approach used is panel data regression using a fixed effect model. The findings show that government spending and foreign direct investment have positive and significant contributions to the economic growth of seven ASEAN countries. There is strong evidence that the interaction between fiscal levels and corruption can distort …

Money Demand Stability With Endogenous Structural Breaks And The Role Of Payment System Innovation In Indonesia, Wishnu Badrawani

Jurnal Ekonomi dan Studi Pembangunan

This study examines the stability of the demand for money function in Indonesia using quarterly data from 2007 to 2021, employing Gregory-Hansen's (1996) cointegration test and Hendry's general-to-specific approaches. The cointegration and error correction models show a causal relationship between money demand and its conventional determinants and payment system innovation. Considering the central bank policy that part of economic reforms captured by the structural break in the cointegration test and the stability test results of the short-run analysis, we confirm the stable narrow money and currency demand and its dynamics in Indonesia. The Gregory and Hansen test found a cointegrating …

The Role Of Tourism Sector On Central Java Economy, Sotya Fevriera, Agatta Shelly Septya Agni

Jurnal Ekonomi dan Studi Pembangunan

The purpose of this research is to analyze the effect of the tourism sector on the economy of Central Java province. The analysis method is a random effect model (REM), which is estimated using data from 35 regencies/cities in Central Java during some periods between 2001 and 2023. The result shows that the number of tourists, the number of tourism objects, the number of lodgings, the number of restaurants, and the number of workers on the tourist object, each have a positive and significant effect on the real GRDP. Moreover, this research also found that there is a random effect …

Determinants Of Generation Z Working In The Formal And Informal Sectors In West Nusa Tenggara, Luluk Fadliyanti, Wan Roshidah Fadzim, Vici Handalusia, Muhammad Dzul Fadlli

Jurnal Ekonomi dan Studi Pembangunan

This study aims to analyze the factors influencing Generation Z’s decision to work in either the formal or informal sectors in West Nusa Tenggara. A descriptive quantitative approach combined with binary logistic regression analysis was employed. The population consists of 968 Generation Z individuals aged 15–26 years who are currently employed and earning income. The study utilizes secondary data from the August 2023 National Labor Force Survey (SAKERNAS), obtained from the Central Statistics Agency (BPS) of West Nusa Tenggara Province, covering respondents across ten districts and cities. The results indicate that income and age have a negative and statistically significant …

Does Gross Regional Domestic Product (Grdp) Affect Poverty In South Sulawesi? Two-Stage Least Squares (2sls) Approach, Abjinda Putra Asmara, Muh. Rasbi, Ishak Ishak, Fasiha Fasiha, Muhammad Nur Alam Muhajir, Muh. Abdi Imam

Jurnal Ekonomi dan Studi Pembangunan

This research aims to determine the simultaneous relationship between poverty and GRDP variables in South Sulawesi. This type of research is quantitative which focuses on revealing simultaneous relationships between variables. The population is Poverty and GRDP data for districts/cities in South Sulawesi Province in 2020. The sample used is a saturated sample of 24 districts/cities sourced from the central statistics agency. Next, this research data was analyzed using the Two-Stage Least Square (2SLS) method. The results of this research show that the poverty variable has a significant effect on GRDP at 5%. Meanwhile, the GRDP variable has a significant effect …

The Role Of Civic Society On E-Governance Adoption: Study On Village-Owned Enterprise Of Pangkah Wetan, Gresik Regency, Didied Poernawan Affandy, Eko Ganis Sukoharsono, Aulia Fuad Rahman, Zaki Baridwan

Jurnal Ekonomi dan Studi Pembangunan

This paper aims to examine the role of civic society on e-governance adoption and to investigate factors that affect the performance of village-owned enterprises as well as their impact. This study is descriptive research using a qualitative approach. Using in-depth interviews and direct observation of informants, the study maps some problems associated with the strategy of e-governance adoption on village-owned enterprise Pangkah Wetan. The case shows that the lack of civic society participation, which is typical across different organizations, does contribute to this problem. However, the main predicament lies with the fact that a good corporate governance principle is never …

Physical Exercise Intervention Improves Cardiac Function And Reduce Recurrences In Non-Permanent Atrial Fibrillation: A Systematic Review And Meta-Analysis, Editya Fukata, Rivaldo Hardani, Nabilah Mukti, Ferrisaga Pranawa, Fahmy Rusnanta, Ardian Rizal

Journal of the Saudi Heart Association

Objectives: Evidences indicate positive effect of physical exercise on exercise capacity and quality of life in patients with AF. However, whether it improves cardiac function and reverse cardiac remodeling in AF patients was unknown. We aim to evaluate the effects of exercise intervention on cardiac function and structure, and the risk of AF recurrence in patients with non-permanent AF. Methods: A systematic review and meta-analysis was conducted following PRISMA guidelines. Searches were performed in PubMed, ProQuest, Google Scholar, ScienceDirect, and Scopus to identify randomized controlled trials (RCTs) comparing exercise interventions combined with standard AF treatment versus standard treatment alone in …

Author Index, 12 Months Ended July 1976, American Institute Of Certified Public Accountants

Tax Adviser

No abstract provided.

Subject Index, 12 Months Ended July 1976, American Institute Of Certified Public Accountants

Tax Adviser

No abstract provided.