Digital Commons Network^™

Parental Psychosocial Outcomes After A Positive Newborn Screen For A Lysosomal Storage Disorder., Courtney D. Berrios, Randi N. Gadea, Meghan Strenk, Twisha Nadella, Jennifer L. Gannon, Janelle R. Noel-Macdonnell Phd

Manuscripts, Articles, Book Chapters and Other Papers

PURPOSE: This study explores the psychosocial impact of a positive newborn screen (NBS) result for four lysosomal storage disorders (LSDs) (Fabry disease, Krabbe disease, Mucopolysaccharidosis Type I, Pompe disease) across confirmatory results.

METHODS: Parents whose child who had a positive NBS for one of the included LSDs were recruited for a retrospective cohort (n = 80) or prospective, longitudinal cohorts (n = 50). Surveys assessed uncertainty, anxiety, intrusive or avoidant thoughts, and perceived vulnerability of their child's health. In-depth interviews explored the NBS experience and psychosocial response.

RESULTS: Participants experienced uncertainty and anxiety during confirmatory testing that improved as parents …

Comparison Of Model-Predicted And Observed Evinacumab Pharmacokinetics And Efficacy In Children Aged < 5 Years With Homozygous Familial Hypercholesterolemia., Sébastien Bihorel, Robert Dingman, Jeanne Mendell, Katy C. Norman, Richard T. George, Xue-Qiao Zhao, Robert Pordy, Daniel Garcia, Wendy S. Putnam, Geetha Raghuveer, Brian W. Mccrindle, Elena Fornari, Ivo Baric, Shubha Srinivasan, Melissa Diamond, Eliot A. Brinton, John D. Davis, A Thomas Dicioccio, Lutz Harnisch

Manuscripts, Articles, Book Chapters and Other Papers

Evinacumab, an angiopoietin-like 3 inhibitor, significantly reduces low-density lipoprotein cholesterol (LDL-C) in patients with homozygous familial hypercholesterolemia (HoFH). Herein, we report pharmacokinetic and efficacy analyses of evinacumab in <  5-year-old patients with HoFH. Population pharmacometric models characterizing evinacumab exposure and LDL-C response accounting for lipoprotein apheresis effect in ≥ 5-year-old patients were adapted for growth and maturation to predict and compare evinacumab and LDL-C concentrations across age/weight groups in virtual ≥ 6-month-old patients receiving 15 mg/kg evinacumab intravenous (iv) infusions every 4 weeks (q4w). As expected from allometric theory, weight-based dosing resulted in decreasing evinacumab exposures with declining body weight. Consistent with trends observed in > 5-year-old patients, the predicted percent change from LDL-C baseline (%∆LDL-C) was generally comparable or even higher in <  5-year-old patients (63.0%-68.5%) than in 5- to <  18-year-old patients (61.3%-67.8%) or adults (51.7%), with the predicted percentages of patients achieving %∆LDL-C > 50% also higher in <  5-year-old patients (82.0%-86.9%) versus 5- to <  18-year-old patients (72.0%-84.5%) and adults (54.8%). Through a managed access program, six 1- to <  5-year-old patients received between 5 and 23 iv infusions of 15 mg/kg evinacumab q4w. Rapid and clinically meaningful LDL-C reductions were observed, with %∆LDL-C at the last reported dose ranging from 41.3% to 77.3%. Based on the actual patient dosing and plasmapheresis history, model-predicted evinacumab and LDL-C concentrations were comparable to the observed data collected in the managed access program. Overall, this analysis provides evidence for the use of evinacumab 15 mg/kg iv q4w dosing regimen in 6-month-old to 5-year-old patients.

Iron Supplementation Switches Mode Of Cell Death To Ferroptosis During Acetaminophen-Induced Liver Injury In Mice Rendering It Resistant To N-Acetylcysteine., Olamide B. Adelusi, Aparna Venkatraman, Jephte Y. Akakpo, Anup Ramachandran, Hartmut Jaeschke

Manuscripts, Articles, Book Chapters and Other Papers

Acetaminophen (APAP) overdose can cause liver injury and is the leading cause of acute liver failure in Western countries. Hepatocellular necrosis induced by APAP involves the formation of a reactive metabolite, triggering mitochondrial oxidant stress and peroxynitrite formation. Iron-catalyzed protein nitration is critical for mitochondrial dysfunction and cell death in the absence of lipid peroxidation (LPO). However, co-treatment of APAP and ferrous sulfate aggravated protein nitration and liver injury but also triggered extensive LPO (measured as malondialdehyde and hydroxy eicosatetraenoic acid (HETE) species). The objective of this study was to evaluate whether the aggravated injury under these conditions is caused …

Preoperative Immobilization For Pediatric Femur Fractures., Connor Mathes, Leilani Mansy, Lisa Berglund, Caleb W. Grote

Manuscripts, Articles, Book Chapters and Other Papers

Guidelines for the definitive surgical management of pediatric femoral shaft fractures have recently been established. Initial preoperative immobilization of these patients varies by age and size; limited guidelines exist to guide caregivers in appropriate preoperative care. Here, we present our recommendations based on clinical experience and literature review. We prefer temporary splints for patients younger than 5 years and Bucks boot traction for skeletally immature patients older than 5 years. In small patients, the splint should extend past the iliac crest and down to the foot to ensure proper immobilization of the femur fracture. For Bucks boot traction, proper traction …

Bilateral Pleuropulmonary Blastoma In An Infant., R Guanà, E Zambaiti, Maria Grazia Sacco Casamassima, S Garofalo, L Lonati, E Stanton, F Gennari

Manuscripts, Articles, Book Chapters and Other Papers

No abstract provided.

Zero Fluoroscopy Ablation Of Arrhythmias In Patients With Congenital Heart Disease, Shailendra Upadhyay, Jenna Schermerhorn, Whitney Fairchild, Jamie Bopp, Irfan Warsy

Manuscripts, Articles, Book Chapters and Other Papers

Aims

Radiation-free catheter ablation is feasible with modern electroanatomic mapping systems. We aimed to evaluate the feasibility, safety, and outcomes of non-fluoroscopic ablation (NFA) in patients with congenital heart disease (CHD).

Methods

We retrospectively reviewed CHD patients who underwent NFA between November 2016 and January 2025. All procedures were performed using the CARTO 3D electroanatomic mapping system. Atrial, ventricular, and aortic geometries were reconstructed as needed. Catheter navigation and sheath placement were guided without fluoroscopy; intracardiac echocardiography was used selectively.

Results

Forty-two patients (23 females) with CHD underwent NFA. The median age was 14 years (range 4–56), and median weight …

Findings From A Pilot Project Highlight Lessons To Ensure Safe Cleaning Practices And Pesticide Use In At-Home Childcare Centers, Elizabeth Friedman, Luke Gard, Sherri G. Homan

Manuscripts, Articles, Book Chapters and Other Papers

Lead and pesticide exposure are leading environmental health concerns for children, and these exposures can result in long-term health consequences, including irreversible cognitive delay and endocrine dysfunction. A pilot program aimed to a) develop and disseminate educational materials and supplies and b) perform in-home childcare facility assessments to increase knowledge regarding lead and pesticide safety, provide education on the health impacts of elevated blood lead levels, and reduce exposure risks in these settings. The program was implemented in St. Louis, Missouri. From outreach and education efforts to interactive feedback, this article shares important lessons learned and highlights educational gaps that …

Metabolic Flexibility As A Candidate Mechanism For The Development Of Postoperative Morbidity, Pietro Arina, John Whittle, Maciej R Kaczorek, Davide Ferrari, Nicholas Tetlow, Amy Dewar, Robert Stephens, Daniel Martin, S Ramani Moonesinghe, Evangelos B Mazomenos, Mervyn Singer

Peninsula Medical School

BACKGROUND: This study investigates the role of metabolic flexibility in determining perioperative outcomes. Metabolic flexibility, a key feature of metabolic health, is the ability to efficiently switch between different fuel sources (predominantly carbohydrates and fats) depending on energy demands and availability. Given the rapidly changing physiological conditions in the perioperative period, we hypothesized that good metabolic adaptability could mitigate postoperative complications. METHODS: We conducted a retrospective observational study utilizing a prospectively collected, single-center preoperative cardiopulmonary exercise testing (CPET) database of patients undergoing a range of major surgeries between 2012 and 2022. On day 3, patients were categorized into 3 groups …

How Do Community Assets Support Health In A Rural Community? An Ethnographic Case Study, Jennie Hayes, Liz Edwards-Smith, Richard Byng, Kerryn Husk, Katrina Wyatt

Peninsula Medical School

Community assets (including voluntary, community, social enterprise and grassroots initiatives) have the potential to help address health inequalities. There is a growing understanding of the importance of putting communities at the heart of public health to improve population health. Understanding the mechanisms by which grassroots activities support health and wellbeing is important for making commissioning decisions, for community confidence and for the purposes of evaluation. This study takes an ethnographic case study approach to explore one rural community in the south-west of England. We observed activities and interactions, had informal conversations with residents and community leaders and conducted focus groups. …

Thalamocortical Structural Covariation Networks Are Related To Familial Risk For Schizophrenia In The Context Of Lower Nuclei Volume Estimates In Patients: An Enigma Study, Annalisa Lella, Linda A. Antonucci, Roberta Passiatore, Loredana Bellantuono, Pierluigi Selvaggi, Teresa Popolizio, Guido Di Sciascio, Alessandro Saponaro, Patrizia Ricci, John Blangero

School of Medicine Publications

Background

Structural brain differences in the thalamus and the cortex have been widely reported in schizophrenia (SCZ) relative to neurotypical control individuals (NCs). Most previous studies examined the thalamusas a whole as a single region of interest. In addition, findings in individuals at familial high risk for SCZ (FHRs) remain inconclusive. Here, we investigated whether local and network-wide thalamic-related structural alterations vary as a function of familial risk for SCZ.

Methods

Structural magnetic resonance imaging scans were obtained from 5197 participants (NC, n = 3409; FHR, n = 257; SCZ, n = 1531) across 32 cross-sectional samples within the …

Enhanced Recovery After Neurosurgery: A Narrative Review Comparing Clinical Outcomes, Protocols, And Challenges With Standard Postoperative Care, Tirath Patel, Hamza Yousuf Ibrahim, Rahma Naveed, Aziz Ur Rehman, Maryam Amir, Fatima Nasir, Anum Zia Khan, Nikhilesh Anand

School of Medicine Publications

Background: By integrating evidence-based pre-, intra-, and postoperative therapies, enhanced recovery after surgery (ERAS) protocols have transformed perioperative care in numerous surgical specialties. Although their use in neurosurgery aims to maximize patient recovery, minimize complications, and reduce hospital stays, the evidence remains heterogeneous, and large randomized controlled trials are scarce.

Objectives: This narrative review contrasts the clinical outcomes, advantages, and challenges of ERAS protocols with those of conventional postoperative care in neurosurgery, with a focus on cranial, spinal, pediatric, cancer, and functional procedures.

Methods: A thematic synthesis of peer-reviewed clinical evidence was conducted using PubMed, Scopus, and Google Scholar (2000-2025). …

Consumers Stabilize Grassland Ecosystem Functions By Destabilizing Belowground Communities Under Abiotic Stress, Jane M. Lucas, Michelle L. Budny, Nathan P. Lemoine

Biological Sciences Faculty Research and Publications

Consumers play a critical role in mediating plant and ecosystem responses to abiotic stress, yet their influence on belowground processes under changing environmental conditions remains underexplored. Insect consumers are vital components of grassland ecosystems that can shape ecosystem function and stability by mitigating how plant and microbial communities respond to abiotic stress, like drought. This study investigates how small-bodied consumers influence the magnitude and stability of grassland belowground functions across gradients of abiotic stress. We conducted a fully factorial field experiment manipulating consumer presence and induced drought over a growing season. Our results reveal that the presence of consumers stabilizes …

Improving Infant Continuity Of Care In An Academic Center Clinic: A Quality Improvement Project., Abiye Y. Okah, Morgen L. Govindan, Rachael D. Dameron, Kristi Williams

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: Continuity of care (COC) with an identified provider is a key principle of the patient-centered medical home. COC may be impacted by other activities that providers practicing in an academic center must engage in. The disruption of care processes during the COVID-19 pandemic led to a decrease in COC for infants attending our academic center's primary care clinic. We implemented a quality improvement (QI) project to improve the rates of infant COC.

METHODS: In 2021, we implemented a QI project with the aim of increasing the percentage of 12-month-old infants who had seen the same provider for at least …

Commentary: Delayed Climate Reporting Requirements Threaten Singapore’S Sustainability Leadership, Jiwei Wang, Holly I. Yang, Liandong Zhang

Research Collection School Of Accountancy

In a commentary by SMU Professor of Accounting (Practice) and Director of Master of Professional Accounting (MPA) and Master of Science in Accounting (MSA) programmes Wang Jiwei, SMU Associate Professor of Accounting, Lee Kong Chian Fellow and Co-Director (Academic Research) of the School of Accountancy Research Centre (SOAR) Holly Yang, and SMU Dean of School of Accountancy and Lee Kong Chian Professor of Accounting Zhang Liandong, they suggested that delaying climate disclosure requirements for small and mid-sized enterprises (SMEs) from 2025 to 2030 could weaken Singapore’s sustainable finance leadership, despite regulators saying the extension would help smaller firms build environmental, …

Associations Between Perceived Stress And Glycemic Measures: Gender And Age As Moderators, Ming-Hong Tsai, Charlene Enhui Goh, Michelle H. Lee, Francine Seah, Maybritte Lim, Eveline Febriana, Jiahui Fu, Julie K. Yip, Philip Presham, Sue-Anne Ee Shiow Toh

Research Collection School of Social Sciences

Introduction Prediabetes presents an opportunity for early intervention. Growing evidence suggests that psychological stress may contribute to glucose dysregulation, but the findings are inconsistent. This study aimed to clarify the association between perceived stress and glycemic measures, by first testing gender as a moderator, and then examining age as a moderator within each gender group. Research design and methods We analyzed cross-sectional data from 470 diabetes-free adults in Singapore. Participants completed the 10-item Perceived Stress Scale, comprising two subscales: perceived helplessness and perceived self-efficacy. Glycemic measures included fasting plasma glucose, glycated hemoglobin, and 2-hour plasma glucose (2h-PG) following an oral …

Research Nexus : Volume 31 - 2025, Office Of Research And Graduate Studies

Office of Research and Graduate Studies

• Researcher Spotlight
• Research Milestones & News
• AKU Kenya Achieves Platinum Certification in Financial Grant Practice
• Research Townhall – Pakistan and United Kingdom
• Research Magazine: In case you missed it!
• Capacity Building Initiatives
• Global Webinar Explores Innovations in Research Administration
• Webinar Strengthens Understanding of Ethical Review in Research
• Community of Practice Explores NIH Other Support Requirements
• The Collective Spark: Our Academic Entities, Institutes and Centres at Work
• New Guidelines Advance Sustainable Cloud Computing for Research in LMICs

Comparison Of Metal Nanoparticles As Antifungal Agents: Efficacy, Mechanisms, And Toxicity Against Candida, Aspergillus, And Cryptococcus, Ahmed Falah Imran, Hayder Hameed Saeed, Khaldoon Jasim Mohammed

AUIQ Complementary Biological System

Candida albicans, Aspergillus fumigatus, and Cryptococcus neoformans are the invasive fungi whose diseases are becoming a growing health issue in the global community, particularly in immunocompromised people. The increasing resistance of the conventional antifungals and the shortage of the existing treatment methods require alternative methods. The present review is an evaluation of the antifungal activity of metal-based nanoparticles, including silver (Ag), copper (Cu), zinc oxide (ZnO), titanium dioxide (TiO₂), and selenium (Se) in relation to the three predominant pathogenic fungi. It also talks about their mode of action, relative efficacy, toxicity and their possible future clinical …

Composing A Kaleidoscope: A Scholarly Personal Narrative Of Academia In A Time Of Digital Overload, Suzanne Porath

Mid-Western Educational Researcher

s Scholarly Personal Narrative (SPN) explores the experience of fractured academic identity amid illness, remote teaching, and digital saturation. Anchored in the methodology of SPN as described by Nash (2004) this narrative integrates personal storytelling with critical reflection and theoretical engagement. Drawing on Rushkoff’s concept of digiphrenia, Makowka’s fractal identity, and Gergen’s absent presence, the paper examines how academic life in the digital age increasingly demands simultaneous performances of self across disjointed timelines and virtual spaces. Through vignettes of presenting at concurrent conferences, teaching from chemotherapy bays, and supporting a dissertation defense in unlikely places, this piece reflects on the …

A Love Letter To My Sisters, Angel Jones

Gatherings

This epistolary submission is written in response to experiences at the State of Women of Color in NY Higher Education symposium in March 2025.

The Paradox Of The Broker: Why Educators Of Color Must Be Supported, Not Just Celebrated, Tatiana C. Parker

Gatherings

In this article, Dr. Tatiana C. Parker examines the transformative potential of social capital brokering within the higher education system, particularly for communities that have been systematically excluded through opportunity hoarding and network closures both historically and presently. Institutions of learning have long served as sites for the transmission of instrumental (tangible) and expressive (emotional) social capital returns. Yet, the same system that has supported mobility is now under attack through the divestment of education, ideological resistance, and the longstanding disenfranchisement of educators of color.

Drawing on her research regarding Black women and upward mobility, she asserts that when educators, …

Women, Race, Recovery: How Some Of History’S Most Impactful Thinkers Reflect On Their Own Healing, Karol Cooper

Gatherings

With examples from influential women of color feminists, the essay points to some obstacles in the way to developing a true practice of recovery for women of color academics whose research brings them in continual contact with histories and enactments of harm against women and people of color. As women of color in higher education, articulating our health and healing needs in our own terms would help us clear a path to promoting ourselves as whole and healthy persons, in addition to promoting us along a career path. The essay collects reflections on health struggles from famous women of color …

The Power Of Community: Creating Pathways For Women Of Color In Higher Education, Dayanara Vázquez Comas Psyd

Gatherings

This essay explores the transformative power of community for women of color navigating the challenges of higher education. Reflecting on personal experiences, it highlights the intersectionality of being both a woman and a member of a minority group in the U.S. Central to overcoming these obstacles is the support of a peer community, which fosters "community healing", a space for shared struggles, validation, and empowerment. The essay calls for intentional efforts to build inclusive communities, mentorship programs, and safe spaces that provide solidarity. It advocates for increased representation at all levels of the higher education journey, viewing it as an …

Calculating The Cost: Loss And Grieving Through The Demands Of Higher Education, Vanessa Rojas

Gatherings

To make it through my final year of my doctoral degree, I had to focus on my research more and my mom less. I had spent most of my life worrying and caring for my mom through her mental health struggles. In September 2017, my mom ended her life. I was pressured into returning to my academic responsibilities shortly after her death. I buried my emotions to get through it. Less than a year later, I started my career in higher education in New York immediately after submitting my dissertation, leaving myself no time to grieve or to be vulnerable. …

A Little Piece Of Her Dies, Keturah L. Hancock

Gatherings

This poem explores the emotional labor of being authentic in spaces not built for women of color. This poem specifically addresses the experiences of Black women. Often, Black women find themselves torn between maintaining peace and being themselves. The poem addresses concepts such as tone policing, code-switching, and expression. It honors Black women in academia who feel they have to shrink themselves to be seen. There is a sense of safety that comes with fitting in and not making waves in a predominantly white space. However, this poem offers an alternative, calling Black women to stand up for those who …

Guerrilleras: Speaking Truths And Strategizing Futures, Estela López

Gatherings

Women of color in higher education face a landscape that can be difficult to navigate for any number of reasons. For those who succeed, our successes and failures are hard fought and even harder won. This personal reflection considers my experiences participating in The State of Women of Color in New York Higher Education, and my goals for sharing about these aspects from my own career. I offer a goal that guided me through what I discussed at the symposium and saw interwoven throughout the day: women of color guerrilleras who come together in a coalition of warrior sisters to …

Gatherings 2.1 Acknowledgement, Table Of Contents And Editors, Roberta Hurtado

Gatherings

Roberta Hurtado, "Acknowledgement" -- Table of Contents -- Editorial Board.

Gatherings 2.1 (Complete Volume), Roberta Hurtado

Gatherings

Proceedings from The State of Women of Color in New York Higher Education.

Roberta Hurtado, "Acknowledgement" -- Table of Contents -- p. vi: Editorial Board.

Journal contents follow: p. 1: Roberta Hurtado (Ed.), "Introduction" -- p. 7: Liz Gil, "Community, Reflection, Wisdom" -- p. 9: Luisa Arroyo Cruzado (narrative) and Julie Fogden (image), "Guerrillera Blesson Interlude I" -- p. 11: Heather Hathaway Miranda, "Round Tables" -- p. 13: Estela López, "Guerrilleras: Speaking Truths and Strategizing Futures" -- p. 17: María Luisa Arroyo Cruzado (narrative) and Julie Fogden (image), "Guerrillera Blesson Interlude II" -- p. 19: Jeanine Irons, "No More Hester …

A Second Chance At The Second Amendment, Blake Creekmur

Kentucky Law Journal

No abstract provided.

The Wnba's 2020 Collective Bargaining Agreement: A Slam Dunk For Working Women And Mothers, Josh Lens

Kentucky Law Journal

No abstract provided.

Faux Federalism, Amanda B. Hurst

Kentucky Law Journal

No abstract provided.