Digital Commons Network^™

Cultivating A Sense Of Community: International Students Navigating Community Engaged Learning Opportunities In Line With Their Social Goals, Katherine Lyon, Nicole Malette

Journal of Comparative & International Higher Education

International students often envision their time studying abroad with particular academic, professional, social, linguistic, and identity-related goals in mind (Fong, 2011; Jones, 2013; Montgomery & McDowell, 2009; Page, 2019; Page & Chahboun, 2019). Post-secondary institutions can provide resources and opportunities to help this heterogeneous group of students bring their vision into fruition. One such opportunity is community engaged learning (CEL), which has been shown to help students expand their social and academic abilities as they make contributions to an organization (Arnold, 2019; Greenberg, London & McKay, 2020; Mayer et al., 2019). Through in-depth interviews with 25 new international students who …

Liver-Directed Base Editing Of Abcc6 Prevents Ectopic Calcification In A Variant-Humanized Mouse Model Of Pseudoxanthoma Elasticum, Lauren C. Testa, Dora Obiri-Yeboah, Hooda Said, Ping Qu, Michael A. Levine, Mohamad-Gabriel Alameh, Kiran Musunuru, Qiaoli Li, Xiao Wang

Department of Biochemistry and Molecular Biology Faculty Papers

Pseudoxanthoma elasticum (PXE) is an autosomal recessive connective tissue disorder characterized by ectopic calcification of elastic fibers throughout the skin, retina, and arteries. It is caused by pathogenic variants in ABCC6 , which encodes a transmembrane transporter that primarily localizes to hepatocytes. Loss of ABCC6 function in hepatocytes leads to systemic deficiency of inorganic pyrophosphate (PPi), a potent inhibitor of calcification; such depletion of PPi from the circulation is responsible for multisystemic ectopic calcification seen in PXE. Therefore, liver-targeted variant correction by genome editing and subsequent restoration of systemic PPi may offer a one-and-done therapeutic approach for PXE. The ABCC6 …

Impact Of Peek Implant Surface Design On Postoperative Complications In Cranioplasty: A Retrospective Review, Carmen A Zavala, Laura Zima, Subhiksha Srinivasan, Sanjay V Neerukonda, Mark J Dannenbaum

Faculty, Staff and Student Publications

Background: The aim of this study was to evaluate and compare complication rates and clinical outcomes associated with smooth and perforated polyetheretherketone (PEEK) implants used in cranioplasty.

Methods: A retrospective analysis of 94 patients who underwent cranioplasty with either smooth (n = 45) or perforated (n = 49) PEEK implants over a five-year period was conducted. Patient demographics, comorbidities, reasons for initial craniectomy, time interval between craniectomy and cranioplasty, postoperative complications, hospital stays, and rates of revision surgeries were analyzed. Multivariate logistic regression was used to control for confounding factors.

Results: No statistically significant differences were observed in demographic characteristics, …

Integrative Profiling Strategies To Guide Personalized Therapy In Mantle Cell Lymphoma: A Pilot Study, Yang Liu, Holly A Hill, Yijing Li, Joseph Mcintosh, Vivian Jiang, Fangfang Yan, Yixin Yao, Yue Fei, Jared Zhang, Lawrence Qu, Jun Yao, Preetesh Jain, Ken Chen, Michael Wang

Faculty, Staff and Student Publications

Mantle cell lymphoma (MCL) responds to frontline therapy but is susceptible to relapse. While Bruton's tyrosine kinase inhibitors (BTKi) achieve high response rates, most patients eventually experience disease progression. Predicting responses to subsequent treatments remains challenging due to the lack of an established platform. Heterogeneity in gene alterations and cellular pathways contribute to resistance, complicating treatment approaches. Here, we present a multi-modal profiling platform, targeting key pathways rather than focusing on singular DNA-associated lesions. We identified dysregulated signaling pathways by performing gene expression profiling on 20 MCL samples using a custom MCL MATCH gene set and analyzed the data with …

Shp2: A Redox-Sensitive Regulator Linking Immune Checkpoint Inhibitor Therapy To Cancer Treatment And Vascular Risk, Silvia Fernanda López Moreno, Stefania Assunto Lenz, Bernardo Casso-Chapa, Angelica Paniagua-Bojorges, Jung Hyun Kim, Nicolas L Palaskas, Kevin T Nead, Venkata S K Samanthapudi, Gilbert Mejia, Oanh Hoang, Jonghae Lee, Steven H Lin, Joerg Herrmann, Guangyu Wang, Syed Wamique Yusuf, Cezar A Iliescu, Noah I Beinart, Charlotte Manisty, Masuko Ushio-Fukai, Tohru Fukai, Pietro Ameri, Roza I Nurieva, Michelle A T Hildebrandt, Keri Schadler, Efstratios Koutroumpakis, Sivareddy Kotla, Nhat-Tu Le, Jun-Ichi Abe

Faculty, Staff and Student Publications

Src homology 2-domain containing protein tyrosine phosphatase 2 (SHP2), encoded by the Ptpn11 gene (Tyrosine-protein phosphatase non-receptor type 11), is a key downstream effector of PD-1/PD-L1 signaling and is likely important, in addition to immune modulation, in tumor development and vascular homeostasis. SHP2 conveys PD-1 mediated inhibitory signaling in T cells, and is emerging as a therapeutic target. Importantly, there is an association between immune checkpoint inhibitors (ICIs), immune-related adverse events (irAEs), and cardiovascular complications, underscoring the need to understand SHP2’s role in these processes. This review aims to summarize current knowledge on SHP2/PTPN11 biology, its role in immune …

Exploring The Interplay Between Hypertension And Osteoporosis: A Narrative Review, Yolanda V. Gutierrez, Ronald Shaju, Alyssa A. Sepulveda, Seval Coban

School of Medicine Publications

Hypertension and osteoporosis are highly prevalent chronic conditions that have significant implications for global health, especially in aging populations. While these conditions have traditionally been viewed as separate, emerging research suggests a strong pathophysiological link between the two. Understanding these shared mechanisms may help improve screening and guide integrated management strategies. This narrative review was conducted between January 2024 and July 2025 using PubMed, ScienceDirect, and Google Scholar. The search strategy used the Boolean string: (“hypertension” OR “high blood pressure”) AND (“osteoporosis” OR “bone loss”), supplemented with pharmacologic terms (“ACE inhibitors,” “angiotensin receptor blockers,” “thiazide diuretics,” “beta-blockers”, “SERMS”, “Bisphosphonates”, “Denosumab”, …

2025-11-21 Faculty Regent Report, Morehead State University. Faculty Senate.

Faculty Senate Records

A summary of the Board of Regents meeting of November 21, 2025 as reported by the Faculty Regent.

Considerations And Guidelines For Clinical Training And Professional Practice In The Area Of Psychotherapy Termination, Elyssa L. Jampolsky

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Treatment termination occurs, invariably, in every psychotherapy relationship. Closing the therapy relationship is often a complex process and requires targeted training for psychotherapists to terminate treatment competently and in a way that preserves gains made and fosters continued client growth. Discontinuation of psychotherapy services requires practitioners to apply ethical knowledge, clinical expertise, and relational boundaries. Further, the nuances of forced, end-of-year termination in clinical training environments necessitates targeted supervision and explicit guidelines. Surprisingly, termination practices are underemphasized in training programs and in the literature. The current paper will review the extant literature related to psychotherapy termination broadly as well as …

Culturally Aware Mindfulness Training For Army Leaders: A Scalable Solution To Strengthen Mental Readiness, Katherine Dutler (Skowronski)

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

This doctoral paper examines cost-effective, easily distributed mindfulness practices as a force-multiplier for psychological readiness in the U.S. Army. Daily mindfulness reduces symptom burden, raises distress tolerance, and sharpens performance—all without added equipment, appointments, or cost. However, stigma, long waitlists, and civilian-centric messaging still deter soldiers from adapting mindfulness practices. Rather than replacing clinicians, the program functions as preventive maintenance and a bridge while soldiers await care, thereby easing load on an overtaxed system. By embedding mental fitness alongside physical PT, the Army can advance its mandate to “deploy, fight, and win” with forces that are both mentally and physically …

Norms For Scaling Up Small And Sick Newborn Care: An Overview Of Reviews, Natalie A. Strobel, Georgia Whisson, Derek Swe, Amy Budrikis, Karen M. Edmond

Research outputs 2022 to 2026

Background: The World Health Organization (WHO) and the United Nations Children's Fund (UNICEF) currently have no benchmarks or 'norms' for scaling up small and sick newborn (SSN) service delivery in health facilities in low- and middle-income countries (LMICs). Our objective was to understand which systematic reviews had addressed the following norms in the last five years: number of SSN beds per live births in a district or similar administrative unit (admission beds); space requirements for SSN units, including mother-infant dyads (space); health workforce ratios in SSN units (workforce); and travel time to health facilities with SSN units (travel time). Methods: …

How Students Of Osteopathy And Physiotherapy View And Perceive Each Other’S Practice, Heather Donaldson, Alec Rickard

School of Health Professions

Purpose: Physiotherapists and Osteopaths have been found to have more similarities than differences but are they able to work well together when necessary. The two professions are likely to share patient populations due to their similarities and it has been found that there are benefits for both clinicians and patients when they are able to work together. Students start to establish their professional identity and lay the foundation of their knowledge of other professions during degree learning, therefore do these professions have knowledge of the other profession and do their views and perceptions align with working in an interprofessional collaboration.Methods: …

Pragmatic Textualism, Brian G. Slocum, Kevin Tobia

Duke Law Journal

Traditional textualism instructs judges to adhere to a statute's linguistic meaning and reject as irrelevant its interpretive consequences. Justice Scalia famously contrasted his restrained textualist judge with "Mr. Fix-It," a judge who inappropriately weighs consequences. Today, however, textualists increasingly embrace consequentialist reasoning. This Article documents this undertheorized shift and the emerging textualist efforts to justify it, including Justices Kavanaugh and Barrett's arguments for nonliteralism and judicial sensitivity to context. This Article critiques these efforts: Modern textualist theory lacks a compelling explanation for its newfound reliance on interpretive consequences.

Next, we offer a novel theory of the linguistic role for interpretive …

An Examination Of Disparities In Adhd Diagnosis Between Men And Women, Julia Holloway

University Honors Theses

Attention Deficit Hyperactivity Disorder has become an increasingly popular area of study over the last decade. The rise in cases over the same period likely explains this trend, as does ADHD’s status as one of the most commonly encountered neurodevelopmental disorders. While much of this research has served as an invaluable asset to both practitioners and patients there are still blind spots which have yet to be addressed by the existing body of research. This progress in our understanding of ADHD has gone far in illuminating the biases which have set the precedent for treatment and diagnosis, however, widespread understanding …

Understanding The U.S. Maternal Healthcare System At The Intersection Of Asian American Birth Outcomes And The Model Minority Stereotype: A Literature Review, Sophia Hevel

University Honors Theses

This thesis aims to explore the maternal healthcare system in the United States as it pertains to Asian American birthing people, the ways in which their racial, ethnic, and cultural identities are interacted with within the U.S. Healthcare system, and subsequently the detrimental effects of the medical system's devaluation of culturally specific birthing and postpartum practices have on Asian American birthing experiences. This will be accomplished through an exploration of the United States' maternal healthcare system, or rather, its crisis; how Asian Americans navigate a system that has not been structured to support their specific needs; and lastly, a discussion …

Art And Critical Thinking, Audrey Nixon

University Honors Theses

The voice of art molds and dictates norms and behaviors of society. Art eases people into sitting with discomfort or alternate ideas of the world. I work with mixed-media collage to respond and react to culture and the current American political climate. Through the act of expressing and working through thoughts and emotions, art teaches people how to process, it teaches histories of resistance, and empathy. Artists have the ability to engage their audience to critically think about what is happening in our world. By channeling expression and passion, art can help people make necessary connections about concepts that lead …

Risk Factors For Unexpected Death In Patients Identified By A Communication And Resolution Program, Peter Lodato, Neal D. Goldstein, Alexandra M, Mapp, Adebayo Gbadebo, David A. Paul

Department of Pediatrics Faculty Papers

Many patients experience unexpected harm while receiving healthcare, with a lasting impact on patients, families, and caregivers. Communication and Resolution Programs are being adopted with increased frequency, as a more systematic, transparent, and equitable approach to these unexpected outcomes. The aim of this study was to identify whether demographic factors played a role in identifying patients with unexpected death, as managed in our CRP. This nested case-controlled compared 236 patients who experienced an unanticipated death with 2,360 controls who died expectedly over a 10-year period. Patients with unexpected death were more likely to be Black (AOR 2.18 95% CI 1.01-4.68), …

Patent Monopsonies, Roy Baharad, Gideon Parchomovsky

Duke Law Journal

Conventional wisdom perceives patent protection as a necessary evil. Patent protection, the argument goes, raises the prices of patented products and processes, thus restricting access to innovation. But without it, not enough innovation will be produced. Hence, generations of scholars have sought ways to curb the market power of patentees via various legal interventions, such as prizes, compulsory licenses, and other forms of regulation. All have tacitly assumed that eroding the market power of patentees would result in a competitive market for innovation that would put an end to the allocative inefficiencies and distributional inequities that emanate from patent protection. …

Incubators Of Innovation: Finding A Place For Title Ix In Religious Charter Schools, Emily Bass

Duke Law Journal

Since the early 1990s, many people across the country have embraced charter schools as "incubators of innovation." Charter schools are publicly funded, tuition-free, K–12 schools that have more flexibility than traditional public schools in curriculum, staffing, and more. With this flexibility, charter schools constantly test new approaches, aiming to inspire educational reform.

In recent years, some have begun calling for a new kind of charter school: the religious charter school. In May 2025, the Supreme Court deadlocked in Oklahoma Statewide Virtual Charter School Board v. Drummund, a case involving St. Isidore, the nation's first explicitly religious charter school. For …

Barriers And Facilitators To Engaging With Academia: A Black Dental Student Perspective – Pilot Study., Amitha Ranauta, Favour Onwudiwe, Tanaka Anthony Jeremy Kadiyo, Obioma Mofiyinfoluwa Ukoha, Rachel Adebukola Anuoluwa Ogunleye, Vivienne Banke Onamusi, Nicole Meerah Elango, Oluwasola Helen Asaolu, Antonia Oluwatosin Oluwakemi Ajayi, Modupe Toluwanimi Osunkoya, Kaamilah Shitta-Bey, Amy Maame Aba Amanfu, Cathy Coelho, Alasdair Robertson, Julie Monk, Nikos Donos, Sally Hanks

Peninsula Dental School

Introduction This pilot study investigates barriers and facilitators to Black dental students' engagement with academic careers in dentistry, focusing on underrepresentation in academia despite efforts to diversify the workforce. Methods and results Through qualitative analysis of focus group discussions with Black dental students from two UK dental schools, several key themes emerged. Participants highlighted the importance of active patronage in addressing underrepresentation, advocating for proactive support systems beyond mere mentoring. They also emphasised the significance of various forms of capital – economic, cultural, and social – in shaping career trajectories and success in academia. Intersectionality, encompassing experiences of sexism, racism, …

Exploring The Perceived Management Priorities Between Physiotherapy And Osteopathy For Chronic Low Back Pain, Mollie Ford, Alec Rickard

School of Health Professions

Purpose:Physiotherapists and osteopaths are integral to the management of chronic low back pain (CLBP), yet patient confusion often arises due to overlap in their roles and techniques. Whilst existing literature has examined the approaches of each profession separately, limited research explores the perceived roles and management priorities. Thus, the aim of this study was to explore the perceived roles and management priorities of physiotherapists and osteopaths in addressing CLBP.Methods:A qualitative phenomenological design was used. Individual online semi-structured interviews were conducted with five UK-based healthcare professionals; two physiotherapists and three osteopaths. Participants were recruited through volunteer sampling and data was collected …

Antidepressant Use In Older Age Bipolar Disorder (Oabd): Results From The Gage-Bd International Consortium, P. J. Chen, Lisa T. Eyler

Faculty Scholarship

Background Antidepressants are still commonly prescribed in bipolar disorders, despite ongoing controversy of the potential risk of inducing hypomania/mania. There is limited knowledge about the characteristics of antidepressant use in older age bipolar disorder (OABD; age ≥50) in the current literature. Aim To describe antidepressant use, sociodemographic and clinical correlates of a global sample of OABD individuals. Methods The Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE-BD) consortium provided cross-sectional international data on OABD individuals ( n = 746) and younger-age bipolar disorder (YABD, age <50 years; n = 692) regarding antidepressant use. Multivariate logistic regression was employed to assess the association between AD use with demographic and clinical variables. Results Of 1252 participants, 33.1 % of OABD individuals and 38.1 % of YABD individuals were using antidepressants. In multivariable models among OABD, antidepressant use was associated with BD type II (OR = 1.61, 95 % CI: 1.09–2.38), higher depression severity (mild-to-moderate: OR = 1.86, 95 % CI: 1.13–3.06; severe: OR = 4.23, 95 % CI: 2.38–7.50), lower YMRS scores (OR = 0.93, 95 % CI: 0.89–0.97), female sex (OR = 1.37, 95 % CI: 1.00–1.89), lower education (OR = 0.61, 95 % CI: 0.43–0.86), and being unemployed (OR = 0.69, 95 % CI: 0.50–0.96). Antidepressant monotherapy was reported in 18 % of OABD users ( n = 46) and 19 % of YABD users ( n = 51). These findings suggest that both clinical severity and sociodemographic characteristics influence antidepressant prescribing in OABD. Conclusion Antidepressant use was less prevalent in OABD compared to YABD, and associated with female sex, lower education, lack of occupation, type II BD, higher depression severity and lower mania scores. In OABD, antidepressants appear to be used more commonly in contexts where they may be clinically more indicated, such as increased depression severity.

The Effect Of Uterine Entry Technique On Chorioamniotic Membrane Separation In Fetoscopic Laser Photocoagulation For Twin-To-Twin Transfusion Syndrome: Protocol For A Randomized Controlled Trial, Brian A Burnett, Jessian L Munoz, Rebecca M Johnson, Christian M Parobek, Luis E Delgadillo Chabolla, Cara Buskmiller, Roopali V Donepudi, Magdalena Sanz Cortes, Michael A Belfort, Ahmed A Nassr

Faculty, Staff and Students Publications

Background: Chorioamniotic membrane separation (CAS) is a recognized complication of fetoscopic laser photocoagulation (FLP) for twin-to-twin transfusion syndrome (TTTS), associated with increased risks of preterm prelabor rupture of membranes (PPROM) and preterm birth (PTB). Although CAS is well described, its incidence and relationship to specific surgical techniques, particularly the method of uterine entry, are not well defined in the published literature. No randomized trials have evaluated whether entry technique influences the risk of CAS.

Methods: We present the protocol for a randomized controlled trial comparing sharp-trocar and Seldinger uterine entry techniques for FLP in TTTS diagnosed between 16 + 0 …

Identifying Compounds To Treat Opiate Use Disorder By Leveraging Multi-Omic Data Integration And Multiple Drug Repurposing Databases, Jeran K Stratford, Megan Ulmer Carnes, Caryn Willis, Melyssa S Minto, Logain Elnimeiry, Ravi Mathur, Matthew Schu, Bryan C Quach, Javan Carter, Tracy Nolen, Nathan Vandergrift, Thomas R Kosten, Eric Otto Johnson, Bradley T Webb

Faculty, Staff and Students Publications

Genes influencing opioid use disorder (OUD) biology have been identified via genome-wide association studies (GWAS), gene expression, and network analyses. These discoveries provide opportunities to identifying existing compounds targeting these genes for drug repurposing studies. However, systematically integrating discovery results and identifying relevant available pharmacotherapies for OUD repurposing studies is challenging. To address this, we've constructed a framework that uses existing results and drug databases to identify candidate pharmacotherapies. For this study, two independent OUD related meta-analyses were used including a GWAS and a differential gene expression (DGE) study of post-mortem human brain. Protein-Protein Interaction (PPI) sub-networks enriched for GWAS …

Diras3-Derived Cyclic Peptides Disrupt Kras-Raf Interaction And Kras Nanoclustering, Suppressing Kras-Driven Pancreatic And Ovarian Tumors, Joshua P Gray, Gamze Bildik, Ha-Neul Kim, Margie N Sutton, Jing Wang, Amarachi O Osuji, Nefeli Batistatou, Hailing Yang, Weiqun Mao, Zhi Tan, Geneviève M C Gasmi-Seabrook, Junchen Liu, John F Hancock, Christopher B Marshall, Joshua A Kritzer, Mitsuhiko Ikura, Robert C Bast, Steven W Millward, Zhen Lu

Faculty, Staff and Students Publications

Mutations in KRAS drive 88% of pancreatic ductal adenocarcinomas (PDAC) and up to 40% of low-grade serous ovarian cancers (LGSOC), making KRAS a long-standing therapeutic target. We previously showed that DIRAS3 binds RAS, forming heterodimers that disrupt RAS clustering and downstream MAPK signaling. Building on this, we developed conformationally constrained DIRAS3-derived peptides using two cyclization strategies and characterized them by NMR and biolayer interferometry. These cyclic peptides attenuate the interaction between KRAS and the BRAF RAS-binding domain, penetrate cells efficiently, and inhibit KRAS nanoclustering on the inner leaflet of the plasma membrane. Functionally, they reduce cell viability and suppress PDAC …

Deletion Of Fibro-Adipogenic Progenitors-Specific Follistatin Impairs Muscle Function And Accelerates Skeletal Muscle Atrophy In Obese Mice, Muhammad Rahil Aslam, Muhammad Bilal, Allah Nawaz, Tomonobu Kado, Shinya Abe, Nguyen Quynh Phuong, Memoona, Sana Khalid, Le Duc Anh, Ayumi Nishimura, Yoshiyuki Watanabe, Yoshiko Igarashi, Naeem Iqbal, Maki Yokoyama, Yasuhiro Onogi, Kennichi Hirabayashi, Hiroyuki Miwa, Takumi Era, Martin M Matzuk, Seiji Yamamoto, Koichi Ikuta, Isao Usui, Kohta Kobayashi, Toshihiko Satake, Masaru Kato, Shiho Fujisaka, Kazuyuki Tobe

Faculty, Staff and Students Publications

Background: Follistatin is a potent regulator of various TGF-β superfamily members, including myostatin (MSTN) and activin A. Previous studies have shown that follistatin is crucial in enhancing myogenesis during acute muscle injury. The mechanism by which fibro-adipogenic progenitors (FAPs)-specific follistatin influences muscle homeostasis in obese mice remains unknown. Therefore, we investigated the physiological role of follistatin in PDGFRα-positive FAPs in the regulation of muscle homeostasis and exercise in obese mice.

Methods: A PDGFRα-specific follistatin knockout (follistatin KO) mouse model was generated using PDGFRα-GFP-CreERT2 (PDGFRα-GCE) and follistatinflox/flox mice. These mice were fed a 60% high-fat diet (HFD) for 20 weeks, followed …

Multi-Parametric Profiling Of Il-7-Augmented Gd2cart Products In A Phase 1 Clinical Trial, Sarah Schulenberg, Martí Farrera-Sal, Michelle Loeser, Lukas Ehlen, Stephan Schlickeiser, Samira Picht, Lena Peter, Marco Mai, Candise L Tat, Jacqueline Keye, Desiree Kunkel, Frank Lin, Cliona M Rooney, Bilal Omer, Michael Schmueck-Henneresse

Faculty, Staff and Students Publications

CAR T cell (CART) therapy holds promise for cancer treatment, but heterogeneity among products limits clinical effectiveness, making systematic profiling essential to identify predictors of success. Recently, a phase 1 clinical trial investigated whether a constitutively active IL-7 receptor (C7R) could safely improve the function and persistence of GD2-directed CARTs (GD2.CARTs) in pediatric patients with high-grade CNS tumors. We analyzed infusion products from trial participants using a custom-designed 33-color full spectrum flow cytometry (FSFC) panel combined with an image-based tumor killing assay to characterize CART products and evaluate the impact of C7R on GD2.CART performance. Patient-specific variations in T cell …

Alteration Of Gut Microbial Ecology By The Direct Activation Of The Brain: Inverse Gut-Microbiome-Brain Dynamics, I-Ching Wang, Jessica L Swanson, Jillian L Waters, Mikhail Y Kochukov, Shelly A Buffington, Sean W Dooling, Benjamin R Arenkiel, Mauro Costa-Mattioli

Faculty, Staff and Students Publications

The gut-microbiome-brain axis is a bidirectional communication system influencing host physiology and overall fitness. While "bottom-up" effects-where gut microbes influence brain function and behavior-are well established, direct evidence for "top-down" modulation-where the brain shapes the gut microbial ecology-remains elusive. Here, we show that the selective expression of the bacterial ion channel mNaChBac in glutamatergic lateral habenula (LHb) neurons increases their bursting activity and leads to endophentypes associated with depression. Importantly, this chronic activation leads to changes in the gut microbiome composition over time, as reflected by shifts in alpha-diversity and alterations in specific microbial taxa. These findings provide direct evidence …

Early Versus Late Weight-Bearing After Ankle Fracture Surgery: A Comparative Review, Bishr Elsharydah, Sarah N. Powell, Urvaksh Avanthsa, Zachary Shorts, Hannah Sudhakar, Megan J. Blount, Ivan Marrufo, Irina D. Sokolik

Student Publications

Early weight-bearing (EWB) and late weight-bearing (LWB) protocols are the two primary regimens implemented for patients following ankle fracture surgery, yet their outcomes remain variable. This review aimed to assess these protocols, including their limitations and implications, to support more tailored postoperative management and ultimately improve patient recovery. EWB demonstrated superior short-term outcomes compared to LWB, including higher functional assessment scores, improved range of motion, and earlier return to work times. However, patients in this group revealed lower protocol adherence and higher wound-related issues in select patients, including complication and reoperation rates. As a result, LWB is more often favored …

Isolated Ipsilateral Hemiparesis From A Pyramidal Decussation Infarct: A Rare Case Confirmed By Magnetic Resonance Imaging, Ali Thahab, Sumeet Bhardwaj, Maher Asfour, Belal Asfour

Student Publications

A 38-year-old male smoker with chronic hypertension, anxiety secondary to alcohol withdrawal, chronic alcohol use, and a history of noncompliance with prescribed medications presented with 2 weeks of progressive left-sided weakness, numbness, dizziness, and gait instability. He also reported a month-long history of facial drooping that had not been formally evaluated. Brain magnetic resonance imaging revealed a small acute/subacute infarct in the left posterolateral cervicomedullary junction, at the level of the pyramidal decussation, which produced ipsilateral motor and sensory symptoms. This is a rare presentation of a stroke causing purely ipsilateral neurologic deficits and served as an important reminder of …

Martial Arts Studies: A Commentary On The Exploration Of Consciousness In Modern Martial Arts, James H. Sutton

Journal of Conscious Evolution

The rapid globalization of martial arts has reconditioned how the beliefs, customs, and philosophies of traditionally based systems are interpreted and applied in modern practice. As contemporary scholarship struggles to accommodate the cultural histories, myths, and traditions that permeate the perception of martial arts in modern contexts, the focus of inquiry has shifted towards explaining cultural variations in practice rather than understanding the nature of self-awareness derived from self-practice. Consequently, the deeper meanings of martial arts as pathways to personal and transpersonal awareness are often invalidated in favor of objective and verifiable explications. In short, the role of consciousness is …