Digital Commons Network^™

Identifying Gaps Through Fetal Infant Mortality Review, Angela M. Schooley

Biennial Convention (CONV)

In the United States, about 23,000 liveborn babies die before their first birthday (National Center for Fatality Review and Prevention (NCFRP), October, 2021). Almost an equal number of babies are stillborn (NCFRP, October 2021). Reducing stillbirths and newborn deaths is a global priority. Ensuring all childbearing women and babies receive the right care, at the right time, from the right people is vital to reduce fetal infant deaths (Homer et al, 2020). The Fetal and Infant Mortality Review (FIMR) examines fetal and infant deaths (National Center for Fatality Review and Prevention (NCFRP), 2024a). FIMR is community owned and action-oriented to …

Sense Of Belongingness In The Nursing Profession: Perception Of Students In A Ghanaian University, Gloria Achempim-Ansong

Biennial Convention (CONV)

The nursing profession is a noble and demanding vocation that requires a deep sense of commitment, compassion, and resilience. Nurses play a pivotal role in providing high-quality care to patients, promoting health and well-being, and serving as advocates for their patients and the healthcare system. However, the journey to becoming a nurse is often fraught with challenges, particularly for undergraduate nursing students who are navigating the complexities of academic and clinical training. Sense of belongingness plays a crucial role in shaping the academic, clinical, and social experiences of undergraduate nursing students.

This study sought to explore the sense of belongingness …

Design And Refinement Of Cybercelltm, A Virtual Reality Health Education Program For Adolescents And Young Adults With Sickle Cell Disease, Aimee Hildenbrand, Melanie Pitone, Benjamin Bear, Corinna L. Schultz, Sherman Finch, Danielle Morley, Stephanie Hubbard, Alyssa Decino, Melissa A. Alderfer, Lori E. Crosby, Fredric Freeman

Department of Pediatrics Faculty Papers

For people living with sickle cell disease (SCD), the risk for disease complications and premature death rises sharply in adolescence and young adulthood, when chronic organ damage is compounded by reduced preventive care. To make informed health care decisions, adolescents and young adults (AYAs) require effective education about their health condition and treatment options. We aimed to systematically design and develop a user-centered, evidence-based virtual reality (VR) health education program to optimize the use of SCD therapies among AYAs with SCD. We engaged a diverse team including AYAs with SCD and their caregivers, multidisciplinary SCD clinicians and researchers, patient education …

Live-Cell Quantitative Monitoring Reveals Distinct, High-Affinity Gβγ Regulations Of Girk2 And Girk1/2 Channels, Reem Handklo-Jamal, Tal Keren Raifman, Boris Shalomov, Patrick Hofer, Uri Kahanovitch, Theres Friesacher, Galit Tabak, Vladimir Tsemakhovich, Haritha P Reddy, Orna Chomsky-Hecht, Debi Ranjan Tripathy, Kerstin Zuhlke, Carmen W Dessauer, Enno Klussmann, Yoni Haitin, Joel A Hirsch, Anna Stary-Weinzinger, Daniel Yakubovich, Nathan Dascal

Faculty, Staff and Student Publications

Gi/o protein-coupled receptors (GPCRs) inhibit cardiac and neuronal excitability via G protein-activated K+ channels (GIRK), assembled by combinations of GIRK1 - GIRK4 subunits. GIRKs are activated by direct binding of the Gβγ dimer of inhibitory Gi/o proteins. However, key aspects of this textbook signaling pathway remain debated. Recent studies suggested no Gi/o-GIRK pre-coupling and low (>250 µM) Gβγ-GIRK interaction affinity, contradicting earlier sub-µM estimates and implying low signaling efficiency. We show that Gγ prenylation, which mediates Gβγ membrane attachment required for GIRK activation, also contributes to the Gβγ-GIRK interaction, explaining the poor affinity obtained with non-prenylated Gβγ. Using quantitative …

Stiefel Md Anderson Oropharynx Cancer (Mda-Opc) Cohort: A Single-Institution, Prospective Longitudinal Outcomes Study, Amy Moreno, Ariana J Sahli, Faye Johnson, Xiaowen Sun, Carly Barbon, Waree Rinsurongkawong, Wenye Song, Flavie M Luciani, Han Liang, Jun Li, Wei Liu, J Jack Lee, S J Frank, Stephen Lai, Clifton Fuller, Katherine Hutcheson

Faculty, Staff and Student Publications

Purpose: The MD Anderson Oropharynx Cancer (MDA-OPC) cohort is a unique single-institution, prospective longitudinal cancer cohort. The cohort aims to enhance the therapeutic index of OPC management by supporting data needs for independent investigators to conduct rigorous observational studies examining exposures and factors associated with acute and late toxicities, cancer progression, recurrence, new malignancies and quality of life in OPC survivors.

Participants: A total of 1811 patients with OPC with a minimum follow-up of 6 months have been consented to our prospective registry between 18 March 2015 and 29 December 2023. Clinical and treatment (Tx) data are available on all …

Mycobacterium Chelonae Outbreak Investigation At A Quaternary Pediatric Hospital Following The Opening Of A Leed-Certified Critical Care Tower: Where Does Water Sustainability Intersect With Infection Control?, Andrea L Ankrum, Silvia M Caceres, Michael Torsell, Elaine Epperson, Vinicius Calado Nogueira De Moura, Jennifer J Gilick, Michael Strong, Qingyun Liu, Matthew J Strand, Rachel N Wilsey, Jennifer R Honda, Jane E Gross, Felicia A Scaggs-Huang

Faculty, Staff and Student Publications

Objective: Investigate the increased incidence of Mycobacterium chelonae positive respiratory cultures in hospitalized patients.

Design: Apply the Healthcare-Associated Links in Transmission of Nontuberculous Mycobacteria (HALT NTM) toolkit to an outbreak investigation of M. chelonae.

Setting: Quaternary-care pediatric hospital and medical center in the United States with a recently opened LEED-certified critical care tower.

Patients: Adult and pediatric patients with M. chelonae positive respiratory cultures between June 2022 and January 2024.

Methods: An epidemiological investigation involving clinical and laboratory practices, water management, building construction and renovation projects. Environmental sampling of air vents, water sources and endoscope reprocessing equipment was performed. M. …

Analysis Of A Deeply-Phenotyped Familial Hypercholesterolemia Cohort From Mexico Shows A Role For Both Rare And Common Alleles Across Known Dyslipidemia Genes And Reveals Structural Variation In A Novel Locus, Nicholas Katsanis, Niki Mourtzi, Consuelo D Quinto-Cortés, Alexandro J Martagon, Alexander G Ioannidis, Francisco M De La Vega, Jeff Gulcher, Ming Ta Michael Lee, Mohammad A Faghihi, Arturo Lopez-Pineda, Sonia Moreno-Grau, Daniel Mas Montserrat, Míriam Barrabés, David Bonet, Pavel Salazar Fernandez, Jeff Wall, Babak Moatamed, Roopa Mehta, Gabriela A Galan-Ramirez, Rafael Zubirán, Daniel Elias-Lopez, Teresa Tusié-Luna, Carlos A Aguilar-Salinas, Carlos D Bustamante

Faculty, Staff and Student Publications

Familial hypercholesterolemia (FH) is a genetic disorder driven in part by mutations in three genes that encode components of the cholesterol pathway: LDLR, APOB, and PCSK9. However, the majority of FH genetics has been performed in individuals of European descent. Here, we leveraged a cohort of 300 patients from the Mexican FH registry to understand how rare, high liability alleles and common variants might contribute to shaping individual risk. Using a combination of whole exome and of short- and long-read whole genome sequencing, we report three key findings. First, we observed that rare pathogenic point mutations and structural variants in …

Naphthalimide-Based Type-I Nano-Photosensitizers For Enhanced Antitumor Photodynamic Therapy: H2s Synergistically Regulates Pet And Self-Assembly, Huiyu Niu, Songnan Wang, Yang Liu, Nana Ma, Shuaiwei Cheng, Beidou Feng, Hyunsun Jeong, Yonggang Yang, Ge Wang, Tony D James, Juyoung Yoon, Jonathan L Sessler, Hua Zhang

Faculty, Staff and Student Publications

Photodynamic therapy (PDT) relies on a combination of light and photosensitizers (PSs) to achieve local control over cancerous lesions. However, it is subject to limitations, including tumor hypoxia, low tumor targeting, off‐target phototoxicity, and always‐on fluorescence. Here, we propose a design strategy for activated nano‐PSs (N‐PSs) to simultaneously overcome the limitations of PDT, wherein photoinduced electron transfer (PeT) is coupled with an endogenous H2S‐regulated self‐association process to promote Type‐I photochemical reactions. Using theoretical calculations, spectral analysis, and microscopic imaging, we verified the generation of self‐assembly and occurrence of PeT. And it was also shown that H2S could synergistically inhibit the …

Serum Levels Of Uchl1 And S100b In Covid-19 And Multiple Sclerosis Patients: A Comparative Study In Erbil City, Krg, Iraq, Daldar Fares Jeejo, Mayada Noori Iqbal, Nisreen Sherif Alyasiri

Baghdad Science Journal

Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) and S100B are proteins involved in neuronal development and damage. Their levels in serum have been proposed as potential biomarkers for various neurological conditions, including COVID-19 and Multiple Sclerosis (MS). The study aimed to compare serum levels of UCHL1 and S100B among COVID-19 patients, MS patients, and healthy controls, and to assess the correlation between these biomarkers in the context of COVID-19. This cross-sectional study included 91 COVID-19 patients, 29 MS patients, and 50 healthy controls from the Kurdistan Region (KRG) of Iraq. Serum levels of UCHL1 and S100B were quantified using enzyme-linked immunosorbent assay …

Efficient Face Mask Recognition Model Based On Deep Learning And Multi-Machine Learning Classifiers, Hassenien Ali Hussein, Firas Muneam Bachay, Saffa Jasim Mosa, Mohammed Hasan Abdulameer

Baghdad Science Journal

Safety in chemical and biological laboratories requires face masks. Nevertheless, the masked face images present obstacles to accommodate the wide pose variations, low resolution, changes in size and incomplete cropping, and varying emotive expressions, making feature extraction and recognition robust difficult. To decern between faces with proper, improper, and no facemask, Deep Learning (the use of Convolutional Neural Networks (CNNs)) and classifiers such as SoftMax, Support Vector Machines (SVM) and K-Nearest Neighbors (KNN) were used. The methodology utilized the 2075 AR face images that contain various resolutions, orientations, and occlusions. The paper develops a Deep Learning-based model utilizing CNNs and …

Enhancing Brain Mri Classification With Gray Wolf Optimization And Swin Transformers, Lamyaa Fahem Katran, Ebtesam N. Alshemmary, Waleed A. Al-Jawher

Baghdad Science Journal

With the rapid advancement of computational power, deep learning has become integral to medical imaging. Convolutional Neural Networks (CNNs) are widely applied to brain MRI scans for tumor classification due to their strong localization and recognition capabilities. However, their limited ability to capture long-range dependencies often leads to information loss and reduced performance in complex feature extraction. To overcome this, the Swin Transformer introduces a hierarchical attention mechanism with shifted windows that preserves spatial relationships and enhances the modeling of global contexts. This architecture improves the detection of intricate tissue textures and supports high-resolution reconstruction of MRI images. Furthermore, integrating …

Bladder Prolapse (Cystocele) Among African, Asian, And Middle Eastern Women: A Clinical And Socio-Cultural Perspective, Gayathri Delanerolle, Vindya Pathiraja, Tharanga Mudalige, Nirmala Rathnayake, Abirame Sivakumar, Wijamunige Nimesha Prashadini, Nihal Mohamed Al Riyami, Lamiya Al-Kharusi, Mohammad Haddadi, Fred Tweneboah-Koduah, Om Kurmi, George Uchenna Eleje, Peter Phiri, Lauri Romanzi, Sohier Elneil

Department of Obstetrics and Gynecology Faculty Papers

Bladder prolapse, also known as cystocoele, is the most common form of pelvic organ prolapse (POP), significantly affecting women's physical, sexual, and psychosocial health, particularly in low- and middle-income countries (LMICs). Despite its widespread prevalence and disabling consequences, bladder prolapse remains under-recognised and inadequately addressed in global health strategies. Prevalence estimates vary widely across regions, from 3%-64.6%, influenced by diagnostic methods and cultural reporting biases. Common risk factors include high parity, early childbirth, prolonged labour, poor postpartum care, malnutrition, obesity, and ageing. Clinical diagnosis often relies on simplified grading systems in resource-limited settings. Conservative treatments like pelvic floor muscle training …

A Contemporary Review On Heart Failure With Improved Ejection Fraction, Allison Weiss, Ambre Flowers, Scott D Eisenberg, Lingling Wu, Mario Rodriguez, Muzamil Khawaja, Errol Moras, Carl J Lavie, Gregg C Fonarow, W H Wilson Tang, Biykem Bozkurt, Chayakrit Krittanawong

Faculty, Staff and Students Publications

Heart failure is a complex condition caused by various etiologies that reduce cardiac output or increase cardiac pressures. It is classified by left ventricular ejection fraction, a key prognostic factor. New therapies, devices, and better management of secondary causes have improved outcomes. A recently identified group-those with heart failure and improved ejection fraction-shows better prognosis. This review explores its definition, causes, clinical significance, and management strategies.

Final Butte Priority Soils Operable Unit (Bpsou) Insufficiently Reclaimed Sites Remedial Action Work Plan (Rawp): Bres No. 104 (Colorado Dump) North Slope, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Barriers And Facilitators To Lifestyle Behavior Change And Goal Setting In Adolescents With Polycystic Ovary Syndrome., Manasa Gadiraju, Joy Y. Kim, Erin M. Green, Alexandra Macmillan Uribe, Honghui Chang, Tania S. Burgert, Melissa D. Olfert, Heidi Vanden Brink

Manuscripts, Articles, Book Chapters and Other Papers

PURPOSE: To identify barriers and facilitators to lifestyle modifications and goal setting and characterize goal setting for adolescents with polycystic ovary syndrome (PCOS).

METHODS: Retrospective chart review of registered dietitian nutritionist (RDN) nutrition notes from 118 adolescents with PCOS 11-21 years evaluated at a multi-specialty PCOS clinic. Goals, barriers, and facilitators were coded using open coding and a priori objectives and characterized for emerging themes using qualitative content analysis.

RESULTS: Five major themes of barriers and facilitators to behavior change emerged: interest and motivation, family involvement, resources and food environment, taste preferences, and self-efficacy. RDNs set ≥3 goals with 52%, …

The Global Hypophosphatasia Registry: Lessons Learned From A Decade Of Real-World Data., Priya S. Kishnani, Lothar Seefried, Keiichi Ozono, Gabriel Ángel Martos-Moreno, Cheryl Rockman-Greenberg, Deborah Fowler, Luke K. Burke, William R. Mowrey, Eric T. Rush, Peter R. Ebeling, Wolfgang Högler, Agnès Linglart, Shona Fang, Anna Petryk, Kathryn M. Dahir

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: Hypophosphatasia (HPP) is an inherited, metabolic, rare disease characterized by a high level of clinical heterogeneity. In response to this robust heterogeneity, the Global HPP Registry was formed to characterize the types of manifestations that patients may experience, as well as to compile information on genetic underpinnings of the disease, overall impact on patient quality of life, and safety and effectiveness of enzyme replacement therapy. The objective of this review was to synthesize key learnings gained from the Global HPP Registry, which is now in its tenth year of enrolling patients.

METHODS: Registry data were analyzed to provide up-to-date …

Geographic And Socioeconomic Predictors Of Early Follow-Up Loss In Patients Undergoing Pituitary Neuroendocrine Tumors (Pitnets) Resection: A Retrospective Review Of 1143 Cases, Daniel Quintana, Rithvik Ramesh, Robert C. Osorio, Wesley Shoap, Paul Mcmillan Villalobos, Philip V. Theodosopoulos, Sandeep Kunwar, Jose Gurrola, Ivan H. El Sayed, Manish K. Aghi, Ezequiel Goldschmidt

School of Medicine Faculty Publications

OBJECTIVE: Postoperative follow-up after PitNET resection is essential for monitoring tumor recurrence and endocrinological deficits. Despite advances in telehealth, loss to follow-up remains a persistent challenge across neurosurgical patients. This study aims to identify factors to identify patients are at higher risk of being lost to follow-up after surgery. METHODS: A retrospective analysis was conducted on 1,143 adult patients who underwent PitNET resection between 2012 and 2019 at a single institution. Clinical and radiological data were analyzed to assess loss to follow-up in the cohort. Multivariable logistic and negative binomial regression models were used to identify factors independently associated with …

Between Sovereignty And Commons: Legal Frameworks For Digital Data Governance In India, Anushka Sachan

Journal of Law and Public Policy

This legislative note critically examines the Indian Digital Personal Data Protection (DPDP) Act, 2023, with a focus on its provisions that imply data sovereignty and their implications for the governance of digital commons. Drawing on the seminal works on data commons, the note explores the conceptual and practical tensions between centralised data sovereignty, participatory, and decentralised models of data stewardship. While data sovereignty is often justified on grounds of national security and control, it may inadvertently hinder the development of inclusive and accountable frameworks for managing data as a public good.

The Effect Of Three Precooling Methods On Endurance Performance In Active Men, Bahman Mirzae, Mohammadreza E. Toloee, Omid Malekshahi, Victor Romano

International Journal of Exercise Science

International Journal of Exercise Science 18(6): 1410-1421, 2025. https://doi.org/10.70252/ERZX6867 The study aimed to compare the effect of three precooling techniques (internal, external, and combined) on the time to reach exhaustion in active men. Eight active men (23 ± 2 yrs; 178 ± 6 cm; 73 ± 11 kg) participated] in 4 exhaustive test sessions with a minimum power output of 40Wmax. Sessions included consumption of 7.5 grams of ice water with a temperature of -1 degree per kilogram of body weight, cold towels (4-6°C) used to cool the skin surface], a combination of ice water consumption and a towel cooling, …

Shu World Review- November 23rd 2025, Diplolab

SHU World Review

No abstract provided.

State Of California Cannabis Reporting, University Of Mississippi – National Center For Cannabis Research And Education

California

No abstract provided.

Analysis Of The Submergence, Landing, And Navigation Of An Autonomous Underwater Landing Vehicle, Theresa Wainwright

Electronic Theses and Dissertations

Autonomous Underwater Landing Vehicles allow for seafloor data to be taken in multiple locations with little to no human intervention. The movement of these vehicles needs to be analyzed through simulated to ensure the correct programming of vehicle missions. This analysis includes the surface navigation, the drift experienced by the vehicle during descent, and the seafloor stability of the vehicle. The results then inform the limitations of this vehicle and the necessary adjustments to subsequent versions. Surface navigation allows understanding of vehicle movement between ascent locations, waypoints, and descent locations. Drift during descent allows for visual of the vehicle’s movements …

Exploring The Recognition Of Internalizing Problems Among Black Students: Delving Into The Youth Mental Health Help-Seeking Pathway, Marketta A. Adams

LSU Master's Theses

The mental health of Black adolescents is a growing concern, with high prevalence rates of internalizing disorders such as anxiety and depression. National studies report that nearly 47% of Black adolescents experience a mental health disorder by age 18, with over 60% reporting moderate to severe depressive symptomology. Despite these alarming rates, Black youth underutilize mental health services, often due to cultural stigma, limited access to culturally competent care, and under-recognition of their mental health needs. This study aimed to explore problem recognition as a key component in the mental health help-seeking pathway for Black adolescents in school settings. Grounded …

“What Are We And What’S Coming Next?”: Queer People’S Experiences During Sociopolitical Unrest In The Us, Ariana Cristal Morales

Master's Theses

Queer (lesbian, gay, bisexual, transgender, queer, or other gender and sexual identities) folx have become a major focal point during political elections. As political climates have projected forced attacks towards queer populations, society has followed suit. Investigation on the impacts of such changes towards queer folx is important to uncover, as sociopolitical climates have shifted within the last 10 years in the US. The present study utilizes a phenomenological framework to understand the lived experiences of queer participants living in the US from 2015-2025 during political and social shifts. Semi-structured interviews were utilized to explore 10 queer participant’s lived experience …

War Abstracted, Jay Hatfield

Electronic Theses and Dissertations

War Abstracted is an exhibition in response to the devastation of war. The body of work encapsulates three years of artistic exploration at Florida Atlantic University. The exhibit is a reaction to contemporary conflicts, both global and domestic. It is neither a glorification nor a condemnation of war. The exhibition reflects my experience as a Marine Corps Scout during the Gulf War, the challenges of reintegrating into society with post-traumatic stress disorder (PTSD), and uncertainty. It also engages broader themes of global warming and gun violence. Through a diverse range of materials, methods, and presentations, the work navigates personal and …

Sustained Cellular Survival Amid Amyloid Beta (Aβ) Burden, Giselle Shim

Electronic Theses and Dissertations

Amyloid beta (Aβ) accumulation is a hallmark of Alzheimer’s disease (AD), persisting in the brain for years. Despite its neurotoxic potential, widespread neuronal death is not consistently observed. Histopathological analysis indicates that most neurons remain viable, suggesting an altered survival state under chronic Aβ burden. This study integrates clinical, imaging, and in vitro evidence to characterize this non-lethal state. FDG-PET imaging reveals reduced glucose metabolism. In vitro, Aβ exposure leads to decreased uptake of glucose and amino acids. Reductions in ATP levels and AMPK activity indicate impaired metabolic regulation. Despite these metabolic disruptions, cell death is not observed, implying a …

Profiling Tumour-Infiltrating Immune Cells In A Large Paediatric Medulloblastoma Cohort: A Retrospective Analysis, Mingze Chen, Xiangjun Shi, Yi Wang, Jiao Zhang, Jirong Guo, Xiuchen Guan, Yu Sun, Wenhao Wu, Chunde Li, Yongji Tian, Yunwei Ou, Tian Li, Kai Jiang, Michael D Taylor, Xuebin Liao, Liwei Zhang, Tao Sun

Faculty, Staff and Students Publications

Background: Tumour-infiltrating immune cells exert both pro-tumour and anti-tumour effects on intracranial tumours. In this study, we investigated the prognostic value of various infiltrating immune cells in medulloblastoma (MB) within a large cohort.

Methods: We employed multiplex immunofluorescent (mIF) staining of tissue microarrays to assess the densities of T cells, B cells, NK cells, macrophages, and immune checkpoints in tumour samples from 249 primary paediatric patients with primary MB. Overall survival (OS) analysis, progression-free survival (PFS), and Cox regression analyses were utilised to explore potential relationships between immune cell densities and survival outcomes. Subsequently, multivariate Cox regression was validated using …

Shepherding In France: The Ambiguities Of Caring For Nonhuman Animals In The Roya Valley, France, Daina Pupkevičiūtė

Journal of Ecological Anthropology

F

For over half a century, wolves in France were extinct. In the absence of predators, the shepherds became accustomed to leaving the sheep roaming freely in the mountains in relative safety. However, at the end of the 1980s, wolves returned, resulting in many victims, conflicts, and a stark division between those either for or against the wolf or otherwise sometimes framed as those against or for the survival of the mountain pastoralism tradition. This text looks at the caring relationships humans, such as shepherds, villagers, and others, have towards sheep, wolves, and the landscape in the Roya Valley in …

The Influence Of Russian Folklore On Perceptions Of Female Heroism, Mariia V. Subbotina

Heroism Science

This article examines how Russian folklore traditions have shaped cultural perceptions of female heroism. The study addresses the limited attention given to gendered aspects of heroism, particularly “female” models, which are often linked to self-sacrifice and resilience, in contrast to “male” heroism associated with physical strength and risk. As the first stage of a larger project, this research aims to introduce the issue and identify key archetypes of female heroism. Based on an analysis of A.N. Afanasyev’s collection of fairy tales, three central archetypes of active heroines are identified: the Warrior Woman (Marya Morevna), the Wise Maiden/Enchantress (Vasilisa the Beautiful), …

Masthead, Cleveland State Journal Of Law And Health

Journal of Law and Health

No abstract provided.