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Articles 55561 - 55590 of 1791685
Full-Text Articles in Entire DC Network
Trauma-Informed Care In Oncology, Susan K. Lee, Kevin R. Clark
Trauma-Informed Care In Oncology, Susan K. Lee, Kevin R. Clark
Biennial Convention (CONV)
Introduction: Trauma-informed care (TIC) refers to the widespread impact of trauma on patients, focusing on safety, trust, empowerment, and collaboration. Oncology patients are particularly vulnerable to trauma due to the emotional and physical distress associated with cancer diagnoses and treatments. This literature review examined the role of TIC in oncology, emphasizing its effects on patient outcomes, healthcare provider practices, and challenges in implementation.
Methods: A systematic review was conducted using PRISMA guidelines. Studies published from 2018 to 2024 were selected from PubMed, CINAHL, and PsycINFO. Keywords included "trauma-informed care," "oncology," "patient outcomes," and "interdisciplinary collaboration". A total of 10 studies …
Newly Graduated Registered Nurses Evolving Identity Of Social Justice: A Novel Middle-Range Theory, Mary Erin Hoying, Karen J. Foli, Vicki Simpson, Dongjuan Xu
Newly Graduated Registered Nurses Evolving Identity Of Social Justice: A Novel Middle-Range Theory, Mary Erin Hoying, Karen J. Foli, Vicki Simpson, Dongjuan Xu
Biennial Convention (CONV)
Background: Nursing has long been rooted in social justice, with many pioneering figures advocating for health equity in marginalized communities (Pittman, 2019; Thurman, 2017). The 31% attrition rate among New Graduate Registered Nurses (NGRNs), many of whom leave within their first year, may reflect moral distress faced in environments where equity is not prioritized (ANA, 2015; Epstein et al., 2020; National Academies of Sciences, Engineering, and Medicine, 2021). There is a pressing need for a stronger focus on preparing NGRNs to incorporate social justice into practice to improve community health outcomes.
Purpose: NGRNs undergo significant professional and personal transformations during …
Promoting Collaborative Practice: Interprofessional Education Synergy, Amanda Hudgins, Janice Evans Hawkins, Michelle Thompson, Tom Campbell, Tammy Speerhas, Corrin Gillis
Promoting Collaborative Practice: Interprofessional Education Synergy, Amanda Hudgins, Janice Evans Hawkins, Michelle Thompson, Tom Campbell, Tammy Speerhas, Corrin Gillis
Biennial Convention (CONV)
Background: Interprofessional collaboration among health providers is essential to achieve optimal patient outcomes. Because team-based care is the expected practice among healthcare providers, interprofessional education (IPE) experiences are essential for achieving the foundational knowledge, skills, and abilities to prepare the future healthcare workforce. Interprofessional education, once considered an elective option, is now a curricular requirement of healthcare programs. The purpose of this presentation is to share an effective interprofessional education model that is easily accessible and attainable, improves learning outcomes, and meets curricular requirements across different healthcare professions.
Methods: Students from multiple healthcare disciplines (Nursing, Physical Therapy, Occupational Therapy, Speech …
Becoming A Sexual Assault Nurse Examiner (Sane), Marivic B. Torregosa
Becoming A Sexual Assault Nurse Examiner (Sane), Marivic B. Torregosa
Biennial Convention (CONV)
Aim: The purpose of this study was to describe the lived experiences of nurses on their journey before and after becoming a sexual assault nurse examiner (SANE).
Design: A qualitative descriptive research design was used in this study.
Methods: A semi-structured interview was conducted among ten nurses who completed SANE training from a medically underserved community.
Findings: Perceptions of being valued and supported and program rigor influenced trainees’ commitment to complete the SANE program. Misconceptions about the role changed as trainees were immersed in the training. Being isolated and underutilized from the health care delivery system and the broader …
An Academic-Practice Partnership: A Patient Care Technician Program Advancing Careers In Health Care, Diane Shea, Dympna O'Carroll, Rebecca White, Karina Yotts
An Academic-Practice Partnership: A Patient Care Technician Program Advancing Careers In Health Care, Diane Shea, Dympna O'Carroll, Rebecca White, Karina Yotts
Biennial Convention (CONV)
Purpose: The Patient Care Technician (PCT) pipeline program was developed to address a shortage in unlicensed personnel and provide a pathway for incumbent staff to complete an entry-level clinical training program in an academic and healthcare setting. Optimizing a clinical academic affiliation, the college created a tailor-made program to address the unique requirements of the acute care setting. Eight of the eleven students were multi lingual learners, and all had tenure at the hospital as valued and reliable employees. Students completed six days in lecture, skills lab, and simulation and five days orienting to hospital-specific education. Clinical instructors, known to …
Introduction, Einat Albin
Introduction, Einat Albin
Comparative Labor Law & Policy Journal
PRIVACY PROTECTION has become an increasingly complex and controversial issue, fuelling academic and policy discussions, particularly in relation to new technological advancements. On one hand, there are concerns arising from new technologies becoming the “Big Brother” who is “watching you,” to borrow George Orwell’s iconic phrase from his dystopian novel 1984 — a true panopticon, a modern system of power infringing upon individual liberty, autonomy, and dignity. Concerns also arise from the blurring of boundaries between work life and private life, a phenomenon closely associated with these technologies, which encroach on individuals’ private spheres. On the other hand, some argue …
Bring Your Own Device — Now Hand It Over! Rescuing Workers’ Privacy During Data Searches, Virginia Mantouvalou, Michael Veale
Bring Your Own Device — Now Hand It Over! Rescuing Workers’ Privacy During Data Searches, Virginia Mantouvalou, Michael Veale
Comparative Labor Law & Policy Journal
Technological advancements pose serious threats to workers’ privacy. This article focuses on practices that greatly blur the line between workers’ private life and life at work, such as the practices of “bring your own device,” and linking cloud storage to personal and work devices. The first sees workers allowed to use personal devices for work-related activities, potentially for several employers. The second sees workers using online storage for personal and professional reasons, linking this storage to personal and work devices. Such practices can be useful for workers. However, they also present challenges for workers’ privacy, particularly when other legal frameworks …
Privacy As Professional Identity, Einat Albin
Privacy As Professional Identity, Einat Albin
Comparative Labor Law & Policy Journal
This article explores an important course of action to safeguarding privacy in the workplace, grounded in the professional identity of workers and their corresponding moral and ethical duties towards clients or patients. Described as “privacy as professional identity,” this concept is developed through two key contributions. First, the article argues that workers who are ethically and legally obligated to protect the confidentiality and privacy of their clients or patients — such as psychologists and lawyers — also inherently safeguard their own personal privacy. This argument is substantiated through illustrative examples and anchored in theoretical frameworks concerning the right to privacy. …
Liability, Property, And Inalienability Rules In Employee Data Regulation, Matthew T. Bodie
Liability, Property, And Inalienability Rules In Employee Data Regulation, Matthew T. Bodie
Comparative Labor Law & Policy Journal
Legal protections for workers’ data have usually taken the form of privacy protections designed to deter data processing that is excessive or invasive. Such protections generally fall into the category of liability rules, under which rights can be infringed as long as compensation is provided for the violation. As Guido Calabresi and A. Douglas Melamed have described in “Property Rules, Liability Rules, and Inalienability: One View of the Cathedral,” liability rules are contrasted with either property rules that prevent the involuntary transfer of rights or inalienability rules that prohibit rights transfers altogether. This article explores how property rules and inalienability …
Data-Driven Collective Rights, Tomer Shadmy
Data-Driven Collective Rights, Tomer Shadmy
Comparative Labor Law & Policy Journal
Technological asymmetries in data-driven workplaces increasingly shape power dynamics between employers and employees. This article argues that safeguarding workers’ rights requires transforming collective labour rights into collective technological capabilities. Rather than viewing data rights narrowly as privacy issues, it reframes them as central to broader labour protections. As artificial intelligence enhances employers’ ability to monitor and exploit worker data, workers must be equipped with tools to analyse and act on their collective data. Employers now extract significant value from aggregated personal data, positioning workers as unwitting data providers and limiting workers’ agency. While current laws focus on individual data rights, …
Comment - The Collective Aspect Of Job Seekers’ Data Rights, Katrina Ligett, Ayelet Gordon-Tapiero
Comment - The Collective Aspect Of Job Seekers’ Data Rights, Katrina Ligett, Ayelet Gordon-Tapiero
Comparative Labor Law & Policy Journal
THE WORKPLACE is a complex and dynamic environment that mirrors societal relations and interactions. Given the inherent imbalance of power between employers and workers, as well as the lack of bargaining power of any individual worker, worker unions have emerged to provide workers with a collective voice and place them on more even footing with their employers, allowing them to achieve more than any single worker could on their own (Bok, 1971). Through the assertion of their members’ collective rights, worker unions have played a pivotal role in promoting rights such as fair wages, safe work conditions, health benefits, and …
It Takes Three To Tango: Labour Law, Data Protection, And Collective Voice For The Regulation Of New Technologies In The Workplace, Emanuele Dagnino
It Takes Three To Tango: Labour Law, Data Protection, And Collective Voice For The Regulation Of New Technologies In The Workplace, Emanuele Dagnino
Comparative Labor Law & Policy Journal
The prospect of algorithmic management of workers poses a risk to their dignity, freedom, health and safety and privacy. In their responses to this changed context, German, Italian, and Spanish labour regulators have taken different approaches. This article compares each jurisdiction’s approach to regulation by considering their distinctive features, functions, and objectives. The article goes on to consider the degree to which each jurisdiction’s approach to technological innovation in the workplace is a product of path-dependency, i.e., the extent to which responses to historical technological innovations in the workplace and established conceptions of the exercise of managerial prerogatives through technologies …
Prior Incarceration And Dental Insurance Trajectories Throughout Older Adulthood, A Testa, L Mijares, D B Jackson, V Maroufy, R Samper-Ternent, A C Neumann, R Mungia, K T Ganson, J M Nagata, T Oates
Prior Incarceration And Dental Insurance Trajectories Throughout Older Adulthood, A Testa, L Mijares, D B Jackson, V Maroufy, R Samper-Ternent, A C Neumann, R Mungia, K T Ganson, J M Nagata, T Oates
Faculty, Staff and Student Publications
Objectives: This study examines the relationship between prior incarceration and dental insurance trajectories throughout older adulthood.
Methods: A nationally representative sample of adults aged 55 y and older who participated in the 2012-2020 Health and Retirement Survey was analyzed (n = 6,383). Group-based trajectory modeling was used to identify distinct patterns of dental insurance coverage across the 8 survey waves. Multinomial logistic regression was used to assess the association between prior incarceration and dental insurance trajectory group membership.
Results: Four dental insurance trajectories were identified: persistent dental insurance (30.0%), intermittent high insurance (16.4%), intermittent low insurance (20.4%), and no …
Oshiro V. Oshiro [State Of Nevada], 141 Nev. Adv. Op. 59 (Nov. 26, 2025), Richard Reid
Oshiro V. Oshiro [State Of Nevada], 141 Nev. Adv. Op. 59 (Nov. 26, 2025), Richard Reid
Nevada Supreme Court Summaries
No abstract provided.
Predicting The Response Of Triple Negative Breast Cancer To Neoadjuvant Systemic Therapy Via Biology-Based Modeling And Habitat Analysis, Casey E Stowers, Chengyue Wu, Clinton Yam, Jingfei Ma, Gaiane M Rauch, Thomas E Yankeelov
Predicting The Response Of Triple Negative Breast Cancer To Neoadjuvant Systemic Therapy Via Biology-Based Modeling And Habitat Analysis, Casey E Stowers, Chengyue Wu, Clinton Yam, Jingfei Ma, Gaiane M Rauch, Thomas E Yankeelov
Faculty, Staff and Student Publications
Despite being the standard-of-care treatment, neoadjuvant therapy (NAT) attains a complete response only in approximately half of the patients with triple negative breast cancer. Thus, methods to predict and optimize patient response to NAT are needed. Previously, we employed patient-specific MRI data to calibrate a biology-based mathematical model that describes cell movement, proliferation, and death due to drug at the tumor level and cell proliferation at an image voxel level. We now extend our approach by using MRI data to group voxels into "habitats" whereby tumor cells of a habitat share the same proliferation. With this approach, we now calibrate …
Impact Of Atrial Fibrillation, Diabetes Mellitus, And Obesity On Outcomes With Aspirin Avoidance And Hemocompatibility With A Left Ventricular Assist Device: An Analysis From The Aries-Hm3 Trial, Nir Uriel, Ivan Netuka, Ulrich P Jorde, Francis D Pagani, Jason N Katz, Jean M Connors, Peter Ivak, Daniel Zimpfer, Yuriy Pya, Jennifer Conway, Finn Gustafsson, Sriram Nathan, Anna Mara Scandroglio, Christopher Hayward, David A D'Alessandro, Morgan Collins, Nicholas Dirckx, Mandeep R Mehra
Impact Of Atrial Fibrillation, Diabetes Mellitus, And Obesity On Outcomes With Aspirin Avoidance And Hemocompatibility With A Left Ventricular Assist Device: An Analysis From The Aries-Hm3 Trial, Nir Uriel, Ivan Netuka, Ulrich P Jorde, Francis D Pagani, Jason N Katz, Jean M Connors, Peter Ivak, Daniel Zimpfer, Yuriy Pya, Jennifer Conway, Finn Gustafsson, Sriram Nathan, Anna Mara Scandroglio, Christopher Hayward, David A D'Alessandro, Morgan Collins, Nicholas Dirckx, Mandeep R Mehra
Faculty, Staff and Student Publications
Background: The ARIES-HM3 trial demonstrated the safety and effectiveness of aspirin elimination from the antithrombotic regimen after HeartMate 3 (HM3) left ventricular assist device (LVAD) implantation. We explored the interaction of atrial fibrillation, diabetes mellitus, and obesity (AF/DM/Ob) with aspirin elimination on hemocompatibility-related adverse events at 1-year postimplant.
Methods: This prospective, double-blind, placebo-controlled trial randomized patients with an HM3 LVAD implant to receive aspirin (100 mg/d) or placebo, in addition to a vitamin K antagonist. The primary endpoint was survival free of nonsurgical (>14 days postimplant) hemocompatibility-related adverse events, including stroke, pump thrombosis, bleeding, and arterial peripheral thromboembolism at …
Loss Of Idh1 And Idh2 Mutations During The Evolution Of Metastatic Chondrosarcoma, William Cross, Iben Lyskjær, Christopher Davies, Abigail Bunkum, Ana Maia Rocha, Tom Lesluyes, Fernanda Amary, Roberto Tirabosco, Cristina Naceur-Lombardelli, Mariam Jamal-Hanjani, Charles Swanton, Nischalan Pillay, Simone Zaccaria, Adrienne M Flanagan, Peter Van Loo
Loss Of Idh1 And Idh2 Mutations During The Evolution Of Metastatic Chondrosarcoma, William Cross, Iben Lyskjær, Christopher Davies, Abigail Bunkum, Ana Maia Rocha, Tom Lesluyes, Fernanda Amary, Roberto Tirabosco, Cristina Naceur-Lombardelli, Mariam Jamal-Hanjani, Charles Swanton, Nischalan Pillay, Simone Zaccaria, Adrienne M Flanagan, Peter Van Loo
Faculty, Staff and Student Publications
Driver mutations in IDH1 and IDH2 are initiating events in the evolution of chondrosarcoma and several other cancer types. Here, we present evidence that mutant IDH1 is recurrently lost in metastatic central chondrosarcoma. This may reflect either relaxed positive selection for the mutant IDH1 locus, or negative selection for the hypermethylation phenotype later in tumor evolution. This finding highlights the challenge for therapeutic intervention by mutant IDH1 inhibitors in chondrosarcoma.
Interplay Of Menopause, Coronary Artery Calcium Score And Cardiovascular Disease Risk, Tanisha Mishra, Diksha Sanjana Pasnoor, Murtaza Gandhi, Nida Mohamed, Shaylika Chauhan, Kokou Adompreh-Fia, Kesha Mayank Doshi, Prerana Sevella, Rupak Desai
Interplay Of Menopause, Coronary Artery Calcium Score And Cardiovascular Disease Risk, Tanisha Mishra, Diksha Sanjana Pasnoor, Murtaza Gandhi, Nida Mohamed, Shaylika Chauhan, Kokou Adompreh-Fia, Kesha Mayank Doshi, Prerana Sevella, Rupak Desai
Abington Jefferson Health Papers
BACKGROUND: Postmenopausal women face an increased risk of cardiovascular disease (CVD) due to estrogen withdrawal, which exacerbates traditional cardiovascular risk factors such as dyslipidemia, glucose intolerance, and hypertension. Coronary Artery Calcium Score (CACS), a well-established marker of subclinical atherosclerosis, has emerged as a key predictor of adverse cardiovascular events. Despite the recognized association between menopause and heightened CVD risk, there remains a paucity of literature exploring the specific role of menopause in influencing CACS and its implications for cardiovascular morbidity and mortality.
AIM: To examine the interplay between menopause, CACS, and cardiovascular health by synthesizing existing literature.
METHODS: A comprehensive …
“The Greatest Invasion In History”: The Nineteenth Century Nativist Theory Behind Trump’S 2025 Immigration Agenda, Tamara Shamir
“The Greatest Invasion In History”: The Nineteenth Century Nativist Theory Behind Trump’S 2025 Immigration Agenda, Tamara Shamir
NULR Online
No abstract provided.
Investigating The Neuronal Role Of The Proteasomal Atpase Subunit Gene Psmc5 In Neurodevelopmental Proteasomopathies, Sébastien Küry, Janelle E Stanton, Geeske M Van Woerden, Amélie Bosc-Rosati, Tzung-Chien Hsieh, Lise Bray, Marielle Oloudé, Cory Rosenfelt, Marie Pier Scott-Boyer, Victoria Most, Tianyun Wang, Jonas J Papendorf, Charlotte De Konink, Wallid Deb, Virginie Vignard, Maja Studencka-Turski, Thomas Besnard, Anna M Hajdukowicz, Franziska G Thiel, Sophie Wolfgramm, Laëtitia Florenceau, Silvestre Cuinat, Sylvain Marsac, Yann Verrès, Audrey Dangoumau, Léa Poirier, Ingrid M Wentzensen, Annabelle Tuttle, Cara Forster, Johanna Striesow, Richard Golnik, Damara Ortiz, Laura Jenkins, Jill A Rosenfeld, Alban Ziegler, Clara Houdayer, Dominique Bonneau, Erin Torti, Amber Begtrup, Kristin G Monaghan, Sureni V Mullegama, Catharina M L Nienke Volker-Touw, Koen L I Van Gassen, Renske Oegema, Mirjam S De Pagter, Katharina Steindl, Anita Rauch, Ivan Ivanovski, Kimberly Mcdonald, Emily Boothe, Andrew Dauber, Janice Baker, Noelle Andrea V Fabie, Raphael A Bernier, Tychele N Turner, Siddharth Srivastava, Kira A Dies, Lindsay C Swanson, Carrie Costin, Alali Abdulrazak, Rebekah K Jobling, John Pappas, Rachel Rabin, Dmitriy Niyazov, Anne Chun-Hui Tsai, Karen Kovak, David B Beck, May Christine V Malicdan, David R Adams, Lynne Wolfe, Rebecca D Ganetzky, Colleen C Muraresku, Davit Babikyan, Zdeněk Sedláček, Miroslava Hančárová, Andrew T Timberlake, Hind Al Saif, Berkley Nestler, Kayla King, M J Hajianpour, Gregory Costain, D'Arcy Prendergast, Chumei Li, David Geneviève, Antonio Vitobello, Arthur Sorlin, Christophe Philippe, Tamar Harel, Ori Toker, Ataf Sabir, Derek Lim, Mark J Hamilton, Lisa J Bryson, Elaine Cleary, Sacha Weber, Trevor L Hoffman, Anna M Cueto-González, Eduardo F Tizzano, David Gómez-Andrés, Marta Codina-Solà, Athina Ververi, Efterpi Pavlidou, Alexandros Lambropoulos, Kyriakos Garganis, Marlène Rio, Jonathan Levy, Sarah J Langas, Anne M Mcrae, Mathieu K Lessard, Maria Daniela D'Agostino, Isabelle De Bie, Meret Wegler, Rami Abou Jamra, Susanne B Kamphausen, Viktoria Bothe, Lorraine Potocki, Eric Olinger, Yves Sznajer, Elsa Wiame, Michelle L Thompson, Molly C Schroeder, Catherine Gooch, Raphael A Smith, Arti Pandya, Larissa M Busch, Uwe Völker, Elke Hammer, Kristian Wende, Benjamin Cogné, Bertrand Isidor, Jens Meiler, Clémentine Ripoll, Stéphanie Bigou, Frédéric Laumonnier, Peter W Hildebrand, Evan E Eichler, Kirsty Mcwalter, Peter M Krawitz, Florence Roux-Dalvai, Ype Elgersma, Julien Marcoux, Marie-Pierre Bousquet, Arnaud Droit, Jeremie Poschmann, Andreas M Grabrucker, Francois V Bolduc, Stéphane Bézieau, Frédéric Ebstein, Elke Krüger
Investigating The Neuronal Role Of The Proteasomal Atpase Subunit Gene Psmc5 In Neurodevelopmental Proteasomopathies, Sébastien Küry, Janelle E Stanton, Geeske M Van Woerden, Amélie Bosc-Rosati, Tzung-Chien Hsieh, Lise Bray, Marielle Oloudé, Cory Rosenfelt, Marie Pier Scott-Boyer, Victoria Most, Tianyun Wang, Jonas J Papendorf, Charlotte De Konink, Wallid Deb, Virginie Vignard, Maja Studencka-Turski, Thomas Besnard, Anna M Hajdukowicz, Franziska G Thiel, Sophie Wolfgramm, Laëtitia Florenceau, Silvestre Cuinat, Sylvain Marsac, Yann Verrès, Audrey Dangoumau, Léa Poirier, Ingrid M Wentzensen, Annabelle Tuttle, Cara Forster, Johanna Striesow, Richard Golnik, Damara Ortiz, Laura Jenkins, Jill A Rosenfeld, Alban Ziegler, Clara Houdayer, Dominique Bonneau, Erin Torti, Amber Begtrup, Kristin G Monaghan, Sureni V Mullegama, Catharina M L Nienke Volker-Touw, Koen L I Van Gassen, Renske Oegema, Mirjam S De Pagter, Katharina Steindl, Anita Rauch, Ivan Ivanovski, Kimberly Mcdonald, Emily Boothe, Andrew Dauber, Janice Baker, Noelle Andrea V Fabie, Raphael A Bernier, Tychele N Turner, Siddharth Srivastava, Kira A Dies, Lindsay C Swanson, Carrie Costin, Alali Abdulrazak, Rebekah K Jobling, John Pappas, Rachel Rabin, Dmitriy Niyazov, Anne Chun-Hui Tsai, Karen Kovak, David B Beck, May Christine V Malicdan, David R Adams, Lynne Wolfe, Rebecca D Ganetzky, Colleen C Muraresku, Davit Babikyan, Zdeněk Sedláček, Miroslava Hančárová, Andrew T Timberlake, Hind Al Saif, Berkley Nestler, Kayla King, M J Hajianpour, Gregory Costain, D'Arcy Prendergast, Chumei Li, David Geneviève, Antonio Vitobello, Arthur Sorlin, Christophe Philippe, Tamar Harel, Ori Toker, Ataf Sabir, Derek Lim, Mark J Hamilton, Lisa J Bryson, Elaine Cleary, Sacha Weber, Trevor L Hoffman, Anna M Cueto-González, Eduardo F Tizzano, David Gómez-Andrés, Marta Codina-Solà, Athina Ververi, Efterpi Pavlidou, Alexandros Lambropoulos, Kyriakos Garganis, Marlène Rio, Jonathan Levy, Sarah J Langas, Anne M Mcrae, Mathieu K Lessard, Maria Daniela D'Agostino, Isabelle De Bie, Meret Wegler, Rami Abou Jamra, Susanne B Kamphausen, Viktoria Bothe, Lorraine Potocki, Eric Olinger, Yves Sznajer, Elsa Wiame, Michelle L Thompson, Molly C Schroeder, Catherine Gooch, Raphael A Smith, Arti Pandya, Larissa M Busch, Uwe Völker, Elke Hammer, Kristian Wende, Benjamin Cogné, Bertrand Isidor, Jens Meiler, Clémentine Ripoll, Stéphanie Bigou, Frédéric Laumonnier, Peter W Hildebrand, Evan E Eichler, Kirsty Mcwalter, Peter M Krawitz, Florence Roux-Dalvai, Ype Elgersma, Julien Marcoux, Marie-Pierre Bousquet, Arnaud Droit, Jeremie Poschmann, Andreas M Grabrucker, Francois V Bolduc, Stéphane Bézieau, Frédéric Ebstein, Elke Krüger
Faculty, Staff and Students Publications
Neurodevelopmental proteasomopathies are a group of disorders caused by variants in proteasome subunit genes, that disrupt protein homeostasis and brain development through poorly characterized mechanisms. Here, we report 26 distinct variants in PSMC5, encoding the AAA⁺ ATPase subunit PSMC5/RPT6, in individuals with syndromic neurodevelopmental conditions. Combining genetic, multi-omics and biochemical approaches across cellular models and Drosophila, we unveil the essential role of proteasomes in sustaining key cellular processes. Loss of PSMC5/RPT6 function impairs proteasome activity, leading to protein aggregation, disruption of mitochondrial homeostasis, and dysregulation of lipid metabolism and immune signaling. It also compromises synaptic balance, neuritogenesis, and neural progenitor …
Transcription-Replication Collisions Trigger High-Fidelity Replication Reset, Matthew B Cooke, Kobie T Welch, Laura Deus Ramirez, Katelin M Hagstrom, Alice X Wen, Jennifer A Halliday, Susan M Rosenberg, Christophe Herman
Transcription-Replication Collisions Trigger High-Fidelity Replication Reset, Matthew B Cooke, Kobie T Welch, Laura Deus Ramirez, Katelin M Hagstrom, Alice X Wen, Jennifer A Halliday, Susan M Rosenberg, Christophe Herman
Faculty, Staff and Students Publications
Double-stranded DNA ends arise from external agents or cellular processes like transcription-replication collisions (TRCs), threatening genome stability. Here, we performed genomic CRISPRi screens to uncover DNA end formation factors in Escherichia coli. We discovered that translation-transcription decoupling causes DNA end formation through a TRC-dependent pathway, which is lethal when DNA end processing by RecBCD is disrupted, but not when recombination is disrupted. We find that TRCs cause replisome stalling followed by "rear-ending" from trailing replisomes which generates free DNA ends, rather than strand breaks. Surprisingly, these DNA ends are resolved through a process we call "replication reset", where the stalled …
Waiting Room And Hallway Care For Older Adults: A Qualitative Study With Emergency Nurses And Technicians, Sarah J Nessen, Ari B Friedman, Annika R Bhananker, K Jane Muir, Anita N Chary
Waiting Room And Hallway Care For Older Adults: A Qualitative Study With Emergency Nurses And Technicians, Sarah J Nessen, Ari B Friedman, Annika R Bhananker, K Jane Muir, Anita N Chary
Faculty, Staff and Students Publications
Background: Emergency Department (ED) crowding places older ED patients at risk for adverse outcomes. Crowding often necessitates ED waiting room and hallway care, but there has been limited research on approaches to care for older adults in these settings. Frontline clinician insights can inform best practices for older adults in the context of the ongoing ED crowding crisis. Our objective was to describe the experiences of emergency nurses and technicians in providing waiting room and hallway care for older adults.
Methods: This qualitative study used individual, semi-structured interviews with a purposive sample of 20 ED nurses and technicians at a …
Multimodal Cardiac Imaging Of Immune-Mediated Complications Post Heart Transplantation: A Contemporary Review, Bruno Bezerra Lima, Tam T Doan, Atilla Feher, James C Wilkinson, Marvin W Kronenberg, Chloe Carr, Malek Nayfeh, Tania Ruiz, Luke L Laws, Melissa Lou Silva, John A Wells, Leandro Slipczuk, Emily T Lippincott, John J Carr, Kaushik Amancherla, Cameron Henry, David Parra, Kelly Schlendorf, Quinn S Wells, Sean G Hughes, Jonathan Soslow
Multimodal Cardiac Imaging Of Immune-Mediated Complications Post Heart Transplantation: A Contemporary Review, Bruno Bezerra Lima, Tam T Doan, Atilla Feher, James C Wilkinson, Marvin W Kronenberg, Chloe Carr, Malek Nayfeh, Tania Ruiz, Luke L Laws, Melissa Lou Silva, John A Wells, Leandro Slipczuk, Emily T Lippincott, John J Carr, Kaushik Amancherla, Cameron Henry, David Parra, Kelly Schlendorf, Quinn S Wells, Sean G Hughes, Jonathan Soslow
Faculty, Staff and Students Publications
Heart transplantation significantly enhances survival and quality of life for patients with end-stage heart failure. Despite advances in surgical and postoperative care, immune-mediated complications, acute graft rejection and cardiac allograft vasculopathy (CAV), remain major barriers to long-term success. Acute rejection predominantly affects early posttransplant survival, whereas CAV becomes a leading cause of mortality in later years. The gold standards for diagnosis, endomyocardial biopsy for rejection and coronary angiography for CAV, are invasive and imperfect. Noninvasive multimodality imaging is increasingly used to complement or, in selected scenarios, defer invasive testing. Echocardiography with strain detects early myocardial dysfunction when ejection fraction is …
Clinical And Implementation Outcomes Of An Antimicrobial Stewardship Intervention For Rapid Blood Culture Diagnostics, Monica Abdelnour, Christine R Lockowitz, Evan E Facer, Andrew Atkinson, Sara Malone, Virginia R Mckay, Rebekah E Dumm, Alexander S Plattner, Matthew M Sattler, Jason G Newland
Clinical And Implementation Outcomes Of An Antimicrobial Stewardship Intervention For Rapid Blood Culture Diagnostics, Monica Abdelnour, Christine R Lockowitz, Evan E Facer, Andrew Atkinson, Sara Malone, Virginia R Mckay, Rebekah E Dumm, Alexander S Plattner, Matthew M Sattler, Jason G Newland
2020-Current year OA Pubs
OBJECTIVE: To evaluate the clinical and implementation outcomes of an antimicrobial stewardship program (ASP) intervention to improve antibiotic therapy for a rapid diagnostic test (RDT) for bloodstream infections (BSIs).
DESIGN: Retrospective pre and postintervention study.
SETTING: Single pediatric tertiary center from August 2022 to May 2024.
PARTICIPANTS: Patients presenting with a positive blood culture accompanied by the Verigene (VG) Gram-positive Blood Culture Nucleic Acid (BC-GP) assay. Implementation outcomes surveys were completed by infectious diseases (ID) clinicians and non-ID clinicians.
METHODS: We implemented a 24 hours a day, 7 days a week (24/7) ASP intervention to improve response to BC-GP assay …
An Updated Perspective On Learning, Andrew S. Gibbons Iii
An Updated Perspective On Learning, Andrew S. Gibbons Iii
Faculty Publications
The subject of human learning is revisited. The emergence of new research findings in cognitive neuroscience and related disciplines using new imaging tools and techniques has revealed the existence of not one but two complementary learning systems. A newly-discovered prospection process, interacting with both memory systems, has been revealed as the pivotal mechanism of learning that leads to new experience and new memory records. The universal impact of emotion on this process also receives a new emphasis. This, coupled with the ever-present social environment, show learning to be the result of conversational activity. The existence of this more complete and …
High Prevalence And Atypical Genotype Distribution Of Oral Human Papillomavirus In An East African Hiv Cohort: A Cross-Sectional Study, Ian G. Munabi, Adriane Kamulegeya, Dunstan Kalanzi, David P. Kateete, Fred Collins Semitala, Catherine-Lutalo Mwesigwa, Samuel Kalungi, Jennifer E. Cameron, Kimon Divaris, William Buwembo
High Prevalence And Atypical Genotype Distribution Of Oral Human Papillomavirus In An East African Hiv Cohort: A Cross-Sectional Study, Ian G. Munabi, Adriane Kamulegeya, Dunstan Kalanzi, David P. Kateete, Fred Collins Semitala, Catherine-Lutalo Mwesigwa, Samuel Kalungi, Jennifer E. Cameron, Kimon Divaris, William Buwembo
School of Medicine Faculty Publications
BACKGROUND: Globally, Human Papillomavirus type 16 (HPV-16) is the predominant genotype associated with oropharyngeal cancers. However, little is known about the prevalence and type distribution of Oral Human Papillomavirus (OHPV) in people living with HIV (PLWHIV) in the East African region. The objective of this study was to document the prevalence and circulating genotypes of OHPV infection in a large cohort of PLWHIV attending an urban HIV clinic in Eastern Africa METHODS: This was a cross-sectional study among 1,715 participants of the Makerere University Joint AIDS Program clinic, located in Kampala, Uganda, in East Africa. A salivary sample was collected …
Cognitive Testing Of Candidate Items In A Wellbeing Measure Developed For Aboriginal And Torres Strait Islander Peoples, Alana Gall, Gail Garvey, Kate Anderson, Abbey Diaz, Kirsten Howard
Cognitive Testing Of Candidate Items In A Wellbeing Measure Developed For Aboriginal And Torres Strait Islander Peoples, Alana Gall, Gail Garvey, Kate Anderson, Abbey Diaz, Kirsten Howard
Journal of the Australian Indigenous HealthInfoNet
Purpose Health and wellbeing for Aboriginal and Torres Strait Islander peoples is poorly understood, due to commonly used measures of quality of life and wellbeing not aligning with their collectivist worldviews. The need to develop a wellbeing measure, grounded in the aspects of life that Aboriginal and Torres Strait Islander people identify themselves as important, was therefore a priority. The current study aimed to cognitively assess the face and content validity of a new wellbeing measure under development for Aboriginal and Torres Strait Islander adults. Methods We employed a qualitative cross-sectional cohort design. Forty-nine unique draft wellbeing statements underwent cognitive …
Helping Craft Beer Hunters Make Their Next Great Beer Discovery, Mark Mitchell, Sheila Mitchell
Helping Craft Beer Hunters Make Their Next Great Beer Discovery, Mark Mitchell, Sheila Mitchell
Atlantic Marketing Journal
The number of craft beer producers and consumers in the United States has increased dramatically over the last ten years. This manuscript provides an overview of the craft beer marketplace in the United States with a focus on the craft brewers and retailers as well as the consumers who favor craft beers. Craft beer enthusiasts are a “consumption community” or, a group of consumers who share a deep involvement with the craft beer category. This study presents a list of common business practices designed to appeal to this unique consumer group.
Trusted Advisor: Reality Or Fading Myth?, Stephen C. Carlson, Susanna Warnock, Gerald Sullivan, Margaret Ryder
Trusted Advisor: Reality Or Fading Myth?, Stephen C. Carlson, Susanna Warnock, Gerald Sullivan, Margaret Ryder
Atlantic Marketing Journal
The role of trusted advisor has long differentiated the role of community banking from traditional national banks in its relationship with small businesses. This study serves two purposes. First is to confirm presence of a trusted advisor relationship and secondly, understand the impact of digital banking services on the community banker – small business owner relationship. Using data collected in a survey of community bankers and small business owners in five southeastern United States, this study assesses the viability of the trusted advisor construct by applying the Integrative Model of Organizational Trust (Mayer, Davis, & Schoorman, 1995, 2007), trust-building behaviors …
Effects Of Rehabilitative Device On Parkinsonian Gait, Brooke N. Ray, Ksenia I. Ustinova, Joseph E. Langenderfer
Effects Of Rehabilitative Device On Parkinsonian Gait, Brooke N. Ray, Ksenia I. Ustinova, Joseph E. Langenderfer
International Journal of Exercise Science
International Journal of Exercise Science 18(7): 1422-1440, 2025. https://doi.org/10.70252/TGOI6101 Parkinson’s disease (PD) is second in occurrence among neurodegenerative disorders after Alzheimer’s disease and significantly impacts gait and mobility. This research tested the effect of the NewGait rehabilitative device in PD impaired individuals. Twenty individuals with PD participated in this study. Walking gait for three conditions were analyzed: Normal, wearing NewGait and Post-NewGait. Standard spatial and temporal analysis measures as well as nonlinear measures from recurrence quantification were compared to determine any effects of the device on walking gait. NewGait was perceived to be both comfortable to wear as well as …