Digital Commons Network^™

Next-Generation Salmonella Inactivated Vaccine Platforms And Phytobiotic-Modulated Immune Responses In Poultry, Santiago Uribe Diaz

Graduate Theses and Dissertations

Here, a comprehensive understanding of immune responses triggered by either a multimeric CD40 receptor-agonistic DNA aptamer-based or mannosylated chitosan-based Salmonella Enteritidis inactivated vaccine platforms, along with phytobiotic supplementation as an immune modulatory strategy in response to Salmonella lipopolysaccharides, is presented. This dissertation supports the development of next-generation Salmonella vaccine platforms that simultaneously stimulate both protective cell-mediated and humoral immune responses, while indicating the potential immunomodulatory effects of phytobiotics supplementation to reduce the immunological impact of Salmonella lipopolysaccharides in chickens. The first chapter describes that both vaccine platforms administered in broiler chickens initiated local inflammatory responses, recruiting heterophils and macrophages from …

Social Support And Depression In Latinx Youth: A Meta-Analysis, Dulce Diaz Benitez

Graduate Theses and Dissertations

Although previous meta-analyses have found significant relationships between social support and youth outcomes, neither has included ethnicity as a moderator or even described the ethnic breakdown in the studies analyzed (Chu et al., 2010; Rueger et al., 2016). Studies that have looked at the relationship between social support and outcomes in Latinx youth have found mixed findings. This study examined the relationship between social support and depression in Latinx youth living in the United States. This study also explored differences in the strength of the relationship between social support and depression in several previously studied moderators (function of social support, …

Emotion Regulation Flexibility And Well-Being In College Athletes In Aesthetic Sports, Kaitlyn D. Chamberlain

Graduate Theses and Dissertations

This study examined emotion regulation flexibility and well-being (including psychological well-being, physical well-being, perceived sport performance and worth of sport participation) in athletes in aesthetic sports. This population experiences high environmental demands and constraints and thus low control over their environment. Collegiate athletes within aesthetic sports and female athletes experience specific social factors and demands that threaten their well-being, compared to those experienced by male athletes and athletes within non-aesthetic sports. Consistent with the transactional theory of stress and coping, individuals with less power to regulate their environment will require greater ability to regulate themselves in accordance with their changing …

Perception Of Drinking Water Quality Among Arkansas Residents, Kolade Olawale Olatunde

Graduate Theses and Dissertations

Objective: Perceptions of drinking water quality influence public trust, water consumption behaviors, and the willingness to invest in infrastructure improvements. Despite the importance of safe drinking water, regional and socio-economic disparities impact how residents perceive their tap water and their readiness to pay for enhancements. While past research indicates that negative views of tap water quality have resulted in behavioral changes, the connection between perception and actual household water usage remains ambiguous. This study aims to investigate how perceptions of drinking water quality differ across regions in Arkansas and how residents are willing to invest in quality improvements. Method: A …

World On Fire: The Hunger Games And The Rhetoric Of Revolution, Rachel Olivares

Electronic Theses and Dissertations

In the decade between 2010 and 2020, more people participated in mass protests than at any other point in human history. From the Arab Spring to Occupy Wall Street and Hong Kong’s “umbrella movement,” street demonstrations exploded on a global scale. This period of global unrest coincided with another explosion: the dystopian young adult series The Hunger Games surged in popularity, quickly becoming a cultural phenomenon. Following the release of the book series and its subsequent film adaptations, The Hunger Games became a global symbol of grassroots resistance as social and political movements adopted the language and symbols of its …

Exploring Bonding Through Outdoor Recreation In Foster Care Utilizing Attachment Theory, Casandra L. Barnes

Communication & Theatre Arts Theses

As of 2024, there are over 328,000 children in foster care in the United States (AFCARS, 2024), many of whom experience disrupted attachments and trauma that hinder their ability to form healthy relationships. Drawing from attachment theory, this study explores how outdoor recreational activities can facilitate bonding between foster parents and their foster children. Using a mixed method approach this explorative research project consisted of two phases: a pilot study at the Virginia zoo involving foster families participating in a cooperative outdoor activity and completing post event surveys, and semi-structured interviews with foster parents to examine lived experiences of bonding …

Assessing The Impact Of Maternal Oral Health On The Risk Of Adverse Birth Outcomes, May Amr Salama

Health Services Research Dissertations

Preterm birth (PTB) and low birth weight (LBW) are leading causes of neonatal morbidity and mortality. Maternal periodontal disease (PD) has been increasingly linked to these adverse birth outcomes (ABOs), yet questions about causality and treatment effectiveness persist due to study design heterogeneity and potential unmeasured confounding. These gaps hinder the development of clear clinical and public health guidelines. This dissertation addresses these gaps through three interconnected studies assessing the relationship between maternal oral health and ABOs.

The first study employed a meta-epidemiological analysis of 62 original studies from nine systematic reviews to evaluate the impact of unmeasured confounding on …

Graduate Physical Therapy Students Perceived Benefit Of Prior Anatomy Experiences Following Their First Semester Graduate Physical Therapy Anatomy Course, Austin Alexander

EVMS School of Health Professions Theses & Dissertations

Human anatomy stands as a cornerstone prerequisite for admission into graduate-level Physical Therapy Programs. As such, prior anatomy experiences need to prepare students for success in graduate-level coursework. However, studies have demonstrated that undergraduate anatomy courses vary in their ability to predict success in graduate Physical Therapy anatomy coursework. This research aimed to utilize students' perceptions of their undergraduate anatomy experiences to predict grades in graduate-level Physical Therapy anatomy coursework. The multinomial logistic regression in this study revealed that the absence of perceived preparedness was a significant predictor of membership in the C graduate anatomy grade group. Students who did …

Promises And Perils Of Generative Artificial Intelligence: A Narrative Review Informing Its Ethical And Practical Applications In Clinical Exercise Physiology, Oscar Lederman, Alessandro Llana, James Murray, Robert Stanton, Ritesh Chugh, Darren Haywood, Amanda Burdett, Geoff Warman, Joanne Walker, Nicolas H. Hart

Research outputs 2022 to 2026

Generative Artificial Intelligence (GenAI) is transforming various sectors, including healthcare, offering both promising opportunities and notable risks. The infancy and rapid development of GenAI raises questions regarding its effective, safe, and ethical use by health professionals, including clinical exercise physiologists. This narrative review aims to explore existing interdisciplinary literature and summarise the ethical and practical considerations of integrating GenAI into clinical exercise physiology practice. Specifically, it examines the ‘promises’ of improved exercise programming and healthcare delivery, as well as the ‘perils’ related to data privacy, person-centred care, and equitable access. Recommendations for the responsible integration of GenAI in clinical exercise …

Thermal Management Of Power Electronic Converters In Electric Motor Drives Using Active Thermal Control And Active Cooling, S M Imrat Rahman

All Dissertations

The application of power electronic converters (PEC) in electric vehicles (EVs) has significantly increased due to their enhanced controllability and flexibility. Additionally, Permanent Magnet Synchronous Machines (PMSMs) are favored in EVs for their higher torque, efficiency, performance, and heat dissipation capabilities compared to asynchronous machines. The reliable operation of power converters in PMSM drives is crucial for EV operation, and this is driving interest in developing innovative and sustainable technologies that ensure the safe and reliable functioning of PECs. One of the main challenges in achieving reliable PECs is designing effective thermal management systems to control junction temperature and reduce …

Reverse (Bio)Engineering: A Machine Learning Approach To Optimize Baseball Pitcher Health And Performance, Robert C. Moore

All Dissertations

Ball tracking systems are becoming ubiquitous in sport, creating an unprecedented opportunity for big data applications to optimize human health and performance. These applications are especially common in baseball, a sport known for analyzing ball flight data to quantify performance. Analysts routinely use ball flight data to identify the attributes of top performing pitchers, finding that the best pitchers throw with optimal combinations of release speed and spin to precise locations. However, for certain pitchers, the throwing motion required to produce optimal ball flight places exceedingly high biomechanical load on the elbow, and consequently injury rates continue to rise. This …

Contributions To Statistical Modeling And Estimation Of Rainfall Intensity–Duration–Frequency Curves, Jiyun Huang

All Dissertations

Extreme rainfall can cause flooding, damage infrastructure, and create serious risks for communities. Engineers use Intensity-Duration-Frequency (IDF) curves to estimate precipitation extremes over different lengths of time, such as one hour or one day, and the average time one would expect wait for one of these events to occur. Several approaches exist for estimating IDF curves, but no single approach is known to be best in all cases. In this dissertation, I study statistical methods that aim to improve IDF curve estimation. I use the Canadian Regional Climate Model (CanRCM4) Large Ensemble, which contains 35 independent climate simulations. These simulations …

The Influence Of Tert-Butylhydroquinone (Tbhq) On Acod1/Irg1-Driven Inflammatory Pathways, Alyssa M. Whisel

All Dissertations

The demand for processed foods has led to increased use of synthetic phenolic antioxidants (SPAs), notably tert-butylhydroquinone (TBHQ), to inhibit lipid oxidation and prolong shelf life. While TBHQ is deemed safe at regulated levels, concerns arise from studies indicating potential adverse effects such as oxidative stress, genotoxicity, and impaired immune function. To investigate TBHQ's immunomodulatory effects, RAW 264.7 murine macrophages were pre-treated with TBHQ and subsequently stimulated with lipopolysaccharide (LPS) or polyinosinic-polycytidylic acid (poly I:C, PIC) to simulate bacterial or viral challenges. Results demonstrated that TBHQ at high non-cytotoxic doses reduced nitric oxide and IL-10 production while promoting phagocytosis and …

Teacher Self-Efficacy As A Moderator Of The Relationship Between Perceived Stressors And Overall Stress During The Covid-19 Pandemic: A Study Of Dominican Public-School Teachers In The Usaid Leer Project, Yira I. Vargas

All Dissertations

This study examined the predictive and moderating roles of teacher self-efficacy (TSE) in the relationship between teacher perceived COVID-19 pandemic-related stressors and overall stress among public-school teachers in the Dominican Republic. Using secondary data from the USAID Leer Project (2021), the study analyzed responses from 142 teachers who completed validated instruments measuring teacher self-efficacy (TSES), pandemic-related teacher stressors (Oros et al., 2020), and perceived stress (PSS-14). The study had three main objectives: (1) to examine whether pandemic-related stressors negatively predicted teacher self-efficacy in student engagement, instructional strategies, and classroom management; (2) to determine whether teacher self-efficacy moderated the relationship between …

An Experimental Evaluation Of A Gamified Learning Approach To Address Bullying Knowledge, Perceptions, And Self-Efficacy Among Elementary Students: Playing Yozgoo In Albania, Sashen Rexhepaj

All Dissertations

This study evaluated the effectiveness of Yozgoo's web-based gamified educational intervention in enhancing elementary school students’ knowledge, attitudes, and self-efficacy related to bullying prevention in Albania. Utilizing a true experimental pre-test and post-test control group design, the study involved 120 students (ages 10-12) equally divided by gender and randomly assigned to either an experimental group (n = 60) or a control group (n = 60). The experimental group participated in Yozgoo gameplay sessions over six to eight weeks, while the control group engaged in standard activities without exposure to the intervention.

Three validated measures were administered to assess outcomes: …

Digital Reflections: Evaluating Body Dissatisfaction In Xr Through Eye- And Body-Tracked Virtual Humans, Deyrel Diaz

All Dissertations

In an era where digital and physical realities increasingly intertwine, the perception of body image is undergoing a significant transformation. Traditional understandings of body dissatisfaction, long studied in relation to psychological distress and eating disorders, are now being reshaped by technologies such as Virtual Reality (VR), Augmented Reality (AR), and Artificially Intelligent (AI)- generated media. These technologies have introduced novel ways of experiencing and interacting with the human form, raising critical questions about their impact on self-perception and internalization of beauty standards.

As virtual representations become more prevalent in entertainment, social media, and interactive platforms, it is becoming more crucial …

Evaluating The Efficacy Of Extracorporeal Shockwave Therapy In Postoperative Rehabilitation After Anterior Cruciate Ligament Reconstruction: A Meta-Analysis, Maryam Salimi, Alireza Keshtkar, Seyedarad Mosalamiaghili, Walter Lowe, Aamir Ahmad, Arash Sharafatvaziri

School of Medicine Publications

Background: Recovering from anterior cruciate ligament (ACL) reconstruction can be challenging. While standard rehabilitation helps restore knee function, many patients still face a slow or incomplete recovery. Extracorporeal shockwave therapy (ESWT) has recently gained attention as a potential way to speed up healing and improve outcomes when added to traditional rehab.

Aim: To explore whether combining ESWT with standard postoperative rehabilitation truly leads to better recovery compared with rehab alone.

Methods: A systematic review and meta-analysis were conducted using the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines, evaluating participant status following ACL reconstruction with standard rehabilitation and without …

Archetypes Of Ai Adoption: A Snapshot In Time Of Philanthropic Practice, Grace Lyn Higdon, Linda Raftree

The Foundation Review

The authors identified four archetypes describing philanthropic funders’ approach to AI: The Curious, The Doers, The Dreamers, The Skeptics.

The authors did not find major differences found across foundations based on their geographic location, though there were differences found based on their mission and values. Feminist and social justice funders in the Global South demonstrated more skepticism than others.

Even in seemingly benign or straightforward applications, AI systems demonstrate unpredictable behavior, leading to most foundations proceeding with caution.

The rapid pace of AI has meant that formal AI policies are rare, though foundations align on some common “red lines” that …

Case Study: Using Ai To Design More Effective, Efficient, And Equity Focused Grant Application Review Processes, Emily Yu, Bryan Speelman

The Foundation Review

Grants fuel millions of organizations and advance social innovation across sectors. In the United States, foundations and corporations respectively awarded $103.5B and $36.5B to nonprofits in 2023 alone (Childress, 2024; Lilly Family School of Philanthropy, 2024).

By extension, grant applications play a critical role in how grant recipients are identified and selected. While many funders are eager for more streamlined and equitable processes to review grant applications, the process remains primarily a manual and time consuming one (Hewlett Foundation, 2021). These factors leave some funders implementing grant application processes potentially at odds with their impact goals. Examples include restricting who …

The Ai Contributor: A New Thought Partner In Systems Change, Jewlya Lynn, Rachel Reichenbach

The Foundation Review

Many foundations are making long-term commitments to advancing systemic change, continually adapting and refining their approaches along the way. An emerging and often underutilized tool in their systems change toolkit is generative artificial intelligence (AI).

AI is enhancing practices across philanthropy, often focused on increasing efficiencies and scaling or streamlining human tasks. What if we instead focus on what AI can do that is distinctly different from what a human can offer? In the world of systemic change, we continue to struggle with the complexity and intractability of systems and finding moments when systems can be shifted. AI can be …

Beyond Transactions: Building Relational Partnerships Between Evaluators And Foundations, Lauren Beriont, Cassie Bruny, Madison N. Garcia, Ebonie Guyton, Chelsey Hurt, Leah Josephson, Kate Mallula, Mary Mattson, Rory Neuner, Ramona Perry, Andrea Prado Tuma, Sarah Smith, Kim Van Der Woerd, Sofia Vitalis

The Foundation Review

The co-authors have framed this article as an emergent learning journal of sorts, summarizing observations, findings, and key takeaways; walking the reader through the process, key tensions, and classic myths they identified; and highlighting principles they uncovered that underlie and lay the groundwork for imagining more equitable ways for evaluation consultants and foundations to act in relationships.

Base Building Evaluation: Three Opportunities To Improve Its Use And Relevance, Katie Fox, Margaret A. Post

The Foundation Review

The concept of base building comes from the traditions of electoral and labor organizing, where organizers focus on drawing leadership from a specific constituency or geography. Base building is foundational to organizing efforts. It involves the recruitment, training, and leadership development of people who are often most directly impacted by the issues and causes that organizing focuses on.

In recent years, base building has seen increased interest and investment from the philanthropic sector as funders recognize base building as critical to community-led change. As funders expand their investment in base building, they increasingly seek information and data about base building …

When Shift Happens: Navigating Toward A Framework For Responsible Philanthropic Exits, Laila Bell, Stephanie Teleki, Jaime Vazquez

The Foundation Review

Philanthropy can be a powerful force for social change, with influence extending far beyond the funding period. When foundations decide to cease funding in a specific area, how they exit can significantly impact the field they are leaving in both the short- and long-term. A poorly executed exit risks blindsiding grant partners and communities, damaging key relationships, undermining progress, and potentially leaving the field worse off than it was found. In contrast, a responsible exit can help the work continue long after the foundation ceases its funding.

What defines a responsible exit? In this article, learning leaders at three different …

Philanthropy As Risk Capital: Shaping Trust And Learning At The Speed Of Ai, Nina Sabarre, Clara Bennett, Laura Chavez-Varela

The Foundation Review

As artificial intelligence rapidly reshapes society, philanthropy is increasingly called to act as "risk capital" for the public good. But risk alone is not enough. Without rigorous, field-wide learning, philanthropy's bold bets may remain isolated and short-sighted, failing to catalyze the systemic change this moment demands.

This article draws on three sources of learning at Omidyar Network—an evaluation of The Tech We Want initiative, external strategy consultations with 29 stakeholders, and early learnings from a generative AI portfolio—to identify how philanthropy can uniquely "de-risk" AI innovation for collective benefit.

Through trust-based partnerships, ecosystem infrastructure support, and narrative change, these learning …

Navigating Safety: A Mixed-Methods Examination Of Supportive Workplace Practices In Maritime Contexts, Rebecca N. Pool

All Dissertations

Maritime Sailors operate in high-demand and high-risk environments that require sustained adherence to strict safety standards. Using the Conservation of Resources theory (COR), this dissertation examines how supportive workplace practices impact job stress and foster increased safety compliance among U.S. Navy personnel. Using a mixed-methods design, two studies were conducted with data from the Afloat Safety Climate Assessment Survey (ASCAS). Study 1 analyzed quantitative survey responses from active-duty Sailors (N = 15,517) nested in 1,033 departments nested within 122 ships to test a multilevel moderated mediation model linking social support, job stress, psychological safety, and safety compliance. Results indicated …

Particle Migration In Non-Newtonian Fluid Flows Through Curved Microchannels, Sanskruti Ramesh Raut

All Dissertations

Innovations in microfabrication over the past three decades have enabled the development of microfluidic devices with intricate channel geometry. Microfluidic platforms offer controlled manipulation of fluids and particles by leveraging the internally induced and/or externally imposed force field(s). The demand for compact microchannel geometry has turned the attention toward curved microchannels with significantly reduced footprints. However, most of the previous studies in curved microchannels have been limited to particle migration in Newtonian fluids. The influence of fluid rheology has remained largely unexplored.

In the first part of this dissertation, we present a systematic experimental study on the influences of fluid …

Accident Data Analytics And Ai-Based Auditory Enhancement For Highway Construction Safety, Thinh Nguyen

All Dissertations

This research develops data-driven and AI-enhanced approaches to improve worker safety in highway construction environments. The study integrates advanced analytics and auditory signal enhancement to identify high-risk worker behaviors and improve real-time safety warnings. The work consists of three core studies. The first study applies Sequential Pattern Mining and Social Network Analysis to more than 1,000 construction accident reports to identify high-risk worker actions and their hidden sequential relationships with accident types and consequences. These insights reveal sector-specific risk patterns, supporting the creation of targeted, data-informed safety interventions. The second study introduces an AI-based auditory enhancement model built on a …

Enhancing Teacher Planning Practices To Improve Teacher Self-Efficacy Through Professional Learning Communities, Philip L. Price

All Dissertations

This improvement science dissertation investigated the impact of implementing Professional Learning Communities (PLC) on teacher self-efficacy at Parkway Elementary, a Title I school serving a diverse student population with historically lower academic performance. The study addressed the problem of low teacher self-efficacy, a critical factor influencing Tier 1 instructional quality and student outcomes. Utilizing the Plan-Do-Study-Act cycle, this research tested the theory that adopting a four-question framework within weekly collaborative grade-level meetings would measurably increase teacher self-efficacy. Seven teachers participated in the research, with data collected through the Teacher Sense of Efficacy Scale, semi-structured interviews, and PLC observations. Quantitative findings …

Purifying Circular Rna Therapeutics, Karen Guillen-Cuevas

All Dissertations

Circular RNA (circRNA) has emerged as a promising therapeutic modality due to its enhanced stability and resistance to exonuclease degradation compared with linear mRNA. However, its stability and functionality depend strongly on achieving high purity, and current methods such as size-exclusion chromatography suffer from peak overlap, low yields, and poor scalability. This dissertation addresses these limitations by developing ultrafiltration-based strategies to purify circRNA directly from in vitro transcription (IVT) and self-splicing (circularization) reactions. First, the feasibility of ultrafiltration was demonstrated using polyethersulfone membranes, where sieving coefficients and critical flux values of circRNA, precursor RNA, and nicked RNA were measured to …

Exploring Glycosomes As Therapeutic Targets For Trypanosoma Brucei, Sabrina Sutton Pizarro

All Dissertations

Trypanosoma brucei is a protozoan parasite which causes human African trypanosomiasis and the livestock wasting disease, nagana. These parasites have highly specialized peroxisomes, called glycosomes, which house a variety of essential metabolic pathways, including glycolysis. Glycolysis is the sole means of energy production in the infective life stage of T. brucei making glycosomes and the glycolytic pathway promising targets for therapeutic strategies. In this work, we have studied the glycosome as a therapeutic target from multiple perspectives. The first portion of this work addresses drug trafficking. The efficacy of small-molecule inhibitors of glycosomal enzymes is restricted by the rate of …