Digital Commons Network^™

A Ralgef Inhibitor Suppresses Lung Cancer Stem Cell Development And Tumorigenesis., Raphael Ngozichi Suarez Jigo

Electronic Theses and Dissertations

The RALGEF family of proteins are direct downstream effectors of the RAS oncoprotein. RALGEFs act as guanine nucleotide exchange factors (GEFs) for downstream RAL proteins, thus tying RAS to the regulation of RAL. Genetic studies have demonstrated RAL proteins to be key drivers of RAS-driven transformation and metastasis. Furthermore, this pathway has been implicated in chemoresistance, exocyst-mediated transport, and the modulation of cancer stem cells. Previous work in our lab reported the activity of a novel pan-RALGEF inhibitor (C4-180) against RAS-driven pancreatic cancer models. Here we show the agent to be active against in vitro and in vivo models of …

A Comparision Of Teachers' Ratings Of Published Versus Ai-Generated Descriptions Of Evidence Based Practices In Education., Lora T. Hall

Electronic Theses and Dissertations

The persistent gap between educational research and classroom practice continues to limit teachers’ use of evidence-based practices (EBPs), despite strong empirical support and federal mandates encouraging their implementation. A key barrier to closing this research-to-practice gap is the limited accessibility, usability, and perceived relevance of traditional research dissemination formats. With the rapid rise of artificial intelligence (AI) tools capable of summarizing and restructuring complex information, this study examined whether AI-generated practitioner-oriented descriptions of an EBP would be rated differently from a published practitioner article on the same practice. Using an experimental cross-sectional survey design, 70 in-service teachers were randomly assigned …

An Exploration Of Factors Associated With Sport Fan's' Choice Of Ticketing Platforms., Jacob Owsley

Electronic Theses and Dissertations

This research study examined key experiential and demographic factors associated with sport consumers’ choice of online ticketing platforms. The research applied the technology acceptance model (TAM) to examine how trust, official sponsorship, user interface design, and price consciousness are associated with consumers’ choice between different online ticketing platforms.. Data were collected from 312 adult sport consumers in the United States through an online survey distributed across six Reddit communities focused on ticketing or research activities. Participants included individuals who bought tickets to professional sports events and attended these events during the last 12 months. The expert review process and two …

Integrating Due Process Into Large Language Models., Joshua Paul Johnson

Electronic Theses and Dissertations

This research investigates the ability of large language models (LLMs) to recognize due process issues. Due process is a legal concept focused on the protection of the individual during interactions with government when life, liberty, or property are being impacted. Due process presents both substantive and procedural aspects that are challenging to incorporate into generative artificial intelligence. Through assessing model performance, creating benchmarking techniques, retrieval-augmented generation (RAG), and fine-tuning, this work seeks to measure due process recognition performance and improve performance in identifying due process issues. The results of evaluating larger parameter LLMs such as from Google, Meta, and OpenAI …

Understanding Social And Cognitive Influences In Medical Students' Learning Processes For Step 1: An Interpretivist Case Study., Ashley Elaine Triplett

Electronic Theses and Dissertations

This qualitative interpretivist case study explores, at a singular institution, medical students’ perspectives on the social and cognitive factors influencing the learning process as students prepare for the Step 1 examination. While prior research regarding medical students Step 1 preparation have focused primarily on wellness, stress, and career outcomes, limited studies have examined medical students' lived experiences to navigate what occurs during the learning process while they prepare for this critical exam. Utilizing a qualitative case study approach, this dissertation draws on fourteen student interviews, seven that passed Step 1 on their first attempt, and seven that failed. Findings reveal …

The Important Of Female Coaches: What Barriers They Face, Why They Stay, And What Can Be Done To Attract More., Hayley E. Yourous

Electronic Theses and Dissertations

After the passage of Title IX, there has been an increase in the number of females participating in sports; however, the same cannot translate to women in coaching or leadership positions (Acosta & Carpenter, 2014; Hart et al., 1986; LaVoi & Baeth, 2018). The purpose of this hermeneutic phenomenological study was to explore the lived experiences of females who had served as head coaches in the high school setting with at least eight years of experience as a head coach. The NCAA (2022) reported in 2020 that female coaches accounted for 41.3% of female teams' head coaches, both intercollegiate and …

Building Bridges: An Appreciative Inquiry Approach To The Development Of Professional Learning To Enhance Teacher–Student Relationships For Students With Emotional Behavioral Disorders., Renee Renz

Electronic Theses and Dissertations

Positive teacher-student relationships are essential to student success yet are often difficult to create and maintain with students identified with Emotional Behavioral Disorders (EBD). Students with EBD frequently struggle with emotional regulation and disruptive behaviors, making relationships and trust both essential and challenging. This study addressed the need for professional learning that equipped educators with strategies to build and maintain positive relationships with students with EBD in secondary school settings. Guided by a participatory action research design, this study used Appreciative Inquiry as a framework for engaging expert secondary teachers from Kentucky in co-constructing professional learning. Appreciative Inquiry focused on …

The Autonomic And Arrhythmogenic Effects Of Gestational E-Cigarette Exposure., Brittany Rachelle Reynolds

Electronic Theses and Dissertations

Introduction. E-cigarettes (e-cigs) have been shown to be pro-arrhythmic in both human and male rodent studies; however, little is known about how e-cig use impacts patients with a predisposed heightened risk for arrhythmias, including pregnant women. Both pregnancy and e-cig use have independently been shown to increase heart rate, diminish heart rate variability, and increase ventricular premature beats, which is suspected to be due to sympathetic dominance. Importantly, β-blockers have been shown to reduce sympathetic activity, reduce heart rate, increase HRV, and reduce arrhythmias. Thus, the use of β-blockers may help prevent adverse health effects driven by sympathetic dominance from …

Tumor Infiltrating Lymphocytes: From Discovery To Clinical Application., Lewis Clayton Chew

Electronic Theses and Dissertations

This thesis explores the evolution of TIL therapy from its discovery to clinical application, focusing on its use in treating metastatic cancer. Adoptive cell therapy (ACT), particularly TIL therapy, has emerged as a promising alternative to traditional treatments like chemotherapy. This review article traces the historical development of TILs, highlighting key experiments and clinical trials that have shaped its understanding and application as a therapeutic strategy for patients with metastatic and difficult to treat cancers including melanoma. Importantly, this article highlights recent advancements, including the FDA approval of Lifileucel, and explores emerging strategies to enhance therapeutic efficacy of TILs through …

Be Yourself: Life History Of Gay K-12 Educators In Kentucky And Their Lived Experiences., Kevin L. Garner

Electronic Theses and Dissertations

This qualitative life history study explored the lived experiences of gay male educators navigating authenticity, visibility, and advocacy in K–12 schools across Kentucky. Using Queer Theory as the primary framework, complemented by Queer Pedagogy, Culturally Relevant Pedagogy, and Minority Stress Theory, the research examines how social, institutional, and political contexts shape the professional lives and identity expression of gay men working in educational settings. Semi-structured, in-depth interviews were conducted with ten participants, each sharing life narratives that illuminated the intersection between personal authenticity and professional identity within politically and religiously conservative environments. Through reductive analysis and thematic …

Source Code: A Trade-Related Barrier To The Right To Repair, Anthony D. Rosborough

Reports & Public Policy Documents

In recent years, conflicts between software access restrictions and Right to Repair (R2R) legislation have become a growing concern for policymakers and repair advocates around the world. Consumers have come to increasingly depend on electronic devices that integrate sophisticated hardware and embedded software. When those devices break or require maintenance, owners often lack the software or software-based tools required to fix them. In some cases where replacement parts and information may be readily available, device software and software-integrated tools present a barrier to independent repair. In response, legislators in both the United States and the European Union have been enacting …

Isolated Dc-Dc Converter For An Ev Microgrid, Oscar Yu, William Leiker

Electrical Engineering

This product is a redesign of a DC-DC buck-boost converter which utilizes a new topology, the flyback converter, for use in an electric vehicle (EV) as a microgrid. The main driver behind the redesign is to provide electrical isolation between elements in the microgrid. The EV microgrid consists of the battery, motor, external DC and AC ports, and the power electronics (DC-DC converter and AC-DC inverter) which were designed and built in previous senior projects. Using EV’s as microgrids can help relieve stress from the main power grid caused by charging electric vehicles. Implementing EV’s as a microgrid enables the …

Articulator Volume 31, Issue 4

Metro Denver Dental Society Articulator Magazine

The 4^th Quarter 2025 of the MDDS Articulator Magazine offers a preview of the 2026 Rocky Mountain Dental Convention, taking place January 22–24 in Denver. The collection spotlights RMDC speakers and the future of dentistry, from the rise of AI and the shift toward integrated whole-health care to the hidden challenges of chronic illness, and a commitment to preserving natural dentition. The articles challenge dental professionals to rethink assumptions, embrace interdisciplinary collaboration and adopt more personalized and evidence-driven approaches to care.

Hkc03 - Leading A Horse To Water: Understanding The Potential Consequences Of Ordeals In Subsidized Tariff Pricing, Evan Plous Kresch, Carlota Loran Lopez

Oberlin College Kasper Economics and Business Working Paper Series

Water utilities attempting to balance widespread network access with financial stability in providing services often employ Increasing Block Tariffs (IBTs), where volumetric rates increase nonlinearly with water consumed. The widespread adoption of IBTs by utilities across the world is partly attributed to their ability to cross-subsidize smaller monthly users; however, this often leads to the undesirable outcome that large poor households are shifted into higher tariff blocks. To address this, water utilities often adopt a“social tariff”, with significantly lower rates specifically targeted at poor households. However, most of these social tariff policies require households to opt-in or apply to the …

The Impact Of Supply Chain Structure Diversification On High-Quality Development: A Moderating Perspective Of Digital Supply Chains, Fei Song, Mark Wu, Ruizhi Liu

Business Faculty Publications

This study examines how supply chain structure diversification drives high-quality enterprise development in the digital economy. Using panel data from Chinese listed non-financial firms (2009–2023), we find that diversification of both suppliers and customers significantly improves firms’ total factor productivity (TFP), and the results remain robust after controlling for endogeneity. Mechanism analyses show that diversification enhances innovation capability, sustainability performance, and risk resilience, while digital supply chains strengthen these effects by improving information flow and coordination. Heterogeneity tests reveal that the impact is greater for firms with higher operational efficiency, cultural synergy, and information transparency. Overall, the findings highlight that …

The Icj’S Advisory Opinion On Climate Change, Maria Antonia Tigre, Maxim Bönnemann, Antoine De Spiegeleir

Sabin Center for Climate Change Law

This open-access edited volume offers the first comprehensive analysis of the International Court of Justice’s 2025 Advisory Opinion on the obligations of States in respect of climate change, one of the most consequential developments in international climate law since the adoption of the Paris Agreement. Bringing together leading scholars and practitioners from across public international law, human rights law, environmental law, and global governance, the book examines how the Court reframed climate change as a matter of binding legal obligation rather than political discretion.

The contributions explore the Opinion’s articulation of state duties under treaties, customary international law, and general …

The Legal Framework For Enhanced Rock Weathering In Minnesota, Ashwin Murthy, Korey Silverman-Roati, Romany M. Webb

Sabin Center for Climate Change Law

This paper focuses on one form of carbon dioxide removal, terrestrial enhanced rock weathering, which involves spreading finely ground alkaline rocks over land. Scientists posit that the alkaline materials will bond with carbon dioxide in the air, sequestering it in mineral form, potentially for tens of thousands of years. Within the U.S., Minnesota is thought to be an ideal location for enhanced rock weathering, as it has pre-existing silicate rock reserves and quarrying infrastructure, and appropriate land. However, before enhanced rock weathering can be deployed at scale, further research is required to verify its effectiveness, co-benefits, and risks.

Currently in …

Equality In Sentencing Mitigation, John B. Meixner Jr.

Fordham Law Review

As guilty-plea rates have skyrocketed, sentencing has become an increasingly important part of criminal procedure. With judges often wielding significant discretion at sentencing, a key question is how judges interpret mitigation: evidence about the defendant’s background or the case that supports a reduced sentence. Past empirical research—both experimental and in real-world cases—indicates that mitigation plays an important role in determining sentences. But does mitigation help everyone, or does it reinforce inequalities that frequently infect other areas of criminal procedure? Do low-income Black defendants with appointed counsel benefit from sentencing mitigation as much as wealthier White defendants with private attorneys? Do …

An Arendtian Politics Of Life, Kamryn M. Carter

Senior Theses

As defined in The History of Sexuality (1978), Michel Foucault’s concept of biopolitics focused on a specifically modern phenomenon in which biological processes are used to regulate populations. This concept has been influential in modern analyses of the state such as that of Giorgio Agamben, who sought to both correct and complete biopolitics with his concept of homo sacer as part of his analysis of the concentration camp. This thesis brings the theory of biopolitics into conversation with Hannah Arendt’s politics of life. It seeks to determine the degree to which biopolitics — as seen in the work of Michel …

Prostitution In Video Games: Stigma, Violence And Male Pleasure, Laura Aguilera-Ávila, Lara Escobar Hernández

Dignity: A Journal of Analysis of Exploitation and Violence

Prostitution has traditionally been framed in society as a space significantly determined by patriarchal hierarchies, in addition to being affected on many occasions by stigmatisation and violence. The representation of prostitution and of those who practice it in the media is a topic of special interest, since the discourses and messages disseminated by the media play a fundamental role in socialisation. Video games are not exempt from this debate: with millions of players worldwide and a special reach among young people, they are among the most influential media outlets today. This qualitative research analyses a series of titles, both AAA …

A Change In Practice: Improving Uti Management In A Long-Term Care Facility By Implementing Rapid Urinary Culture Collection Protocols To Enhance Timely Treatment And Reduce Hospitalizations, Tania Ojeda

Doctor of Nursing Practice

ABSTRACT

Background: Urinary tract infections (UTIs) remain a leading cause of morbidity among elderly residents in long-term care facilities, where diagnosis is frequently delayed due to atypical presentation, cognitive impairment, and inconsistent urine specimen handling. Purpose: This quality improvement (QI) project aimed to improve the timeliness and accuracy of UTI management in a memory care facility through standardized evidence-based protocols. Objectives: The project sought to ensure that: (a) 100% of staff would be educated on the protocol; (b) 100% of residents with suspected UTIs would have urine sent for urinalysis and culture within 8 hours of symptom onset; (c) 100% …

Implementation Of The Modified Severity Assessment Scale (Msas) For Alcohol Withdrawal In An Inpatient Psychiatric Unit, Grace R. Lindsey

Doctor of Nursing Practice

Background: Alcohol withdrawal is a potentially life-threatening condition frequently seen in psychiatric inpatient settings, especially among individuals with co-occurring alcohol use disorder and mental illness. The Clinical Institute Withdrawal Assessment for Alcohol Scale-revised, while widely used, depends on patient self-report, making it less effective for individuals with altered mental status or psychosis.

Purpose: This quality improvement project implemented the Modified Severity Assessment Scale, an objective, observation-based alcohol withdrawal protocol, in an inpatient psychiatric setting to improve safety, treatment accuracy, and care standardization.

Objectives: The project focused on ensuring full staff adoption of the protocol, reducing intensive care unit transfers …

Examining And Addressing Increased Hospital Inpatient Falls Rates At An Urban Community Hospital, Juan Lira

Doctor of Nursing Practice

Abstract

Background: Falls are the leading cause of reported injuries within the hospital setting. Injuries from falls occur in about20-45% of the time and is the leading cause of injury and injury death among the adult population. Inpatient falls are associated with an additional $14,0000 per occurrence and a prolonged hospitalization by 6.3 days. Increased falls rates affect hospitals rating, accreditation and reimbursements. This hospital is experiencing inpatient falls that exceed national average and corporate goals.

Purpose: The purpose of this project is to reduce the hospital falls rate by 10% within 90 days of initiating evidence-based evaluation and facility-wide …

Implementation Of An Information Sheet For Pediatric Patients With Autism Spectrum Disorder In An Inpatient Setting To De-Escalate Aggressive Behaviors And Reduce Seclusion Rates, Megan R. Castro

Doctor of Nursing Practice

Introduction: Research shows that most seclusion events in pediatric psychiatric settings involve pediatric patients with neurodevelopmental disorders, particularly autism spectrum disorder (ASD). A lack of provider expertise contributes to elevated seclusion rates, highlighting the need for evidence-based, ASD-informed care.
Purpose: To reduce seclusion events within a pediatric psychiatric facility in South Texas, by implementing an evidence-based intervention upon admission that could decrease aggressive behaviors and the likelihood of requiring seclusion. Evidence summary: Literature and guidelines underscore the importance of identifying sensory triggers and calming strategies at admission. Collaborative care and personalized interventions, such as a patient information sheet that identifies …

Implementing A Cardiac Catheterization Pre-Procedure Protocol To Decrease Avoidable Same-Day Cancellations, Christina C. Perry

Doctor of Nursing Practice

Background and significance of the problem: Pediatric congenital heart defect patients are amongst the sickest hospital population. These patients require planned palliation in the cardiac catheterization lab (cath lab), which has a limited number of providers and appointments available. In the cath lab, the percentage of avoidable same-day cancellations for interventional procedures was found to be greater than 30%, representing significant resource utilization opportunities.

Purpose: The purpose of this project was to develop and implement a standardized, evidence-based pre-procedure protocol to decrease avoidable same-day cath lab cancellations.

Goals and objectives: The goals of this project were a 10% decrease in …

Impact Of Rendering Wastewater Variability On Electrocoagulation - Electroflotation, Katie L. Hardison

All Theses

Rendering is a resource recovery technique commonly utilized to recover fats and proteins from unused animal parts discarded during meat processing and slaughter. Resource recovery involves converting waste products into valuable products. Rendering generates large volumes of heavily polluted wastewater. Pollutant concentrations can vary significantly, although rendering wastewater (RW) has extremely high concentrations of fats, oils, and greases (FOG). To remove pollutants, first chemicals called coagulants are added to RW to encourage pollutants to clump together to form flocs. The flocs are then floated to the surface and removed through the addition of air in a process called dissolved air …

Power, Interests, And Maternal Health Care: A Political Economy Analysis Of Service Delivery Redesign In Kenya, Jacinta Nzinga, Easter Olwanda, Kennedy Opondo, Hillary Kimutai, Jan Cooper, Brian Arwah, Benjamin Tsofa, Edwine Barasa, Kevin Croke

Institute for Human Development, East Africa

The maternal and newborn health (MNH) service delivery redesign (SDR) in Kakamega County, Kenya, represents the country's first system-level reorganization of MNH services. The reform aimed to improve care quality and reduce mortality by centralizing delivery services at designated hubs. Using a political economy lens, we examined how ideology, political dynamics, and institutional structures shaped the agenda-setting, adoption, implementation, and sustainability of SDR. We drew on data from document reviews, stakeholder analysis, semi-structured interviews, and non-participant observation to assess the structural, contextual, and institutional factors influencing the reform. Ambiguity around SDR's purpose contributed to the community's uncertain engagement characterized by …

Evaluating The Housing Disparities Surrounding 1890 Land-Grant Universities And 1862 Land-Grant Universities In The South, Jimmy Henry

All Dissertations

This dissertation investigated the disparities in housing and economic development surrounding 1890 and 1862 land-grant universities in the southern United States, highlighting the differences between Historically Black Colleges and Universities (HBCUs) established by the 1890 Morrill Act, and Predominantly White Institutions (PWIs) established under the 1862 Morrill Act. These Morrill Acts established the first federal support for higher education in agriculture and mechanical arts, granting land and, in the case of 1862 institutions, financial resources:

This dissertation was guided by six research questions, applied by both the Hedonic Price Model and comparative analysis: (1) How do housing structure types differ …

John Henryism And The African American Experience: An Exploration Of Risk And Protective Factors And Health Outcomes, Joseph L. Twitdy

All-Inclusive List of Electronic Theses and Dissertations

Racial discrimination has been tied to adverse mental and physical health outcomes among African Americans. In the face of this adversity, African Americans have developed strategies for coping with everyday experiences of discrimination. One such coping method is based on the concept of John Henryism. The folktale of John Henry tells the story of an African American steel-driver racing against a steam-powered drill to clear a path for trains through a mountain. Although John Henry wins the race, he later dies due to exhaustion, ultimately passing with his hammer in his hand. The psychological concept of John Henryism (JH) refers …

Leadership With A Counseling Perspective: Exploring The Influence Of Counseling Skills On Elementary Principalship Effectiveness, Julie Thacker

All-Inclusive List of Electronic Theses and Dissertations

The purpose of this study was to determine if there are counseling skills that effective elementary school principals possess and to identify those counseling characteristics. The participants consisted of elementary school principals holding membership in the Indiana Association of School Principals. They were asked about school locale, type, administrator gender and race, building level, pre-service training institution, years as an administrator, length of time in current school, counseling licensure, and presence of a licensed school counselor in the school. A total of 201 participants began the survey, and 143 completed it, resulting in a completion rate of 71%. Through exploratory …