Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medicine and Health Sciences (325784)
- Social and Behavioral Sciences (259242)
- Law (183147)
- Education (153958)
- Arts and Humanities (123212)
-
- Life Sciences (116434)
- Medical Specialties (77034)
- Physical Sciences and Mathematics (64844)
- Higher Education (59357)
- Public Health (55643)
- Business (51254)
- History (50476)
- Psychology (48833)
- Medical Sciences (45194)
- Sociology (43965)
- Communication (43609)
- Engineering (41052)
- Nursing (34141)
- Public Affairs, Public Policy and Public Administration (33193)
- Library and Information Science (25740)
- Environmental Sciences (24937)
- United States History (21830)
- Religion (21812)
- Diseases (21751)
- Journalism Studies (21680)
- Mass Communication (21326)
- Educational Administration and Supervision (18004)
- Economics (17951)
- Rehabilitation and Therapy (16630)
- Social History (16393)
- Institution
-
- University of New Mexico (56018)
- University of New Hampshire (43697)
- University of Nebraska - Lincoln (37647)
- University of Montana (27877)
- The Texas Medical Center Library (27454)
-
- University of Colorado Law School (24806)
- University of Mississippi (24678)
- University of South Florida (22929)
- Murray State University (21689)
- Washington University School of Medicine (20184)
- University of Kentucky (18291)
- Georgia Southern University (18175)
- San Jose State University (17419)
- Chulalongkorn University (17317)
- Walden University (16767)
- Utah State University (16513)
- Western Kentucky University (16401)
- Thomas Jefferson University (16382)
- Western Michigan University (16145)
- Gallaudet University (15146)
- Eastern Illinois University (15078)
- Sigma Theta Tau International Honor Society of Nursing (14730)
- Nova Southeastern University (14525)
- University of Central Florida (14425)
- University of Alabama at Birmingham (14418)
- Virginia Commonwealth University (14278)
- University of North Dakota (13937)
- California Polytechnic State University, San Luis Obispo (13717)
- Brigham Young University (12756)
- Bowling Green State University (12539)
- Keyword
-
- Newspaper (30168)
- Humans (28522)
- Female (13573)
- Education (13405)
- COVID-19 (12863)
-
- Student newspaper (12363)
- Male (11816)
- Newspapers (10319)
- Newsletter (9998)
- Animals (9188)
- Bowling Green State University (8945)
- Spartan Daily (8774)
- EIU (8523)
- Michigan (7935)
- History (7325)
- Higher education (7290)
- Eastern Illinois University (7249)
- United States (7247)
- Daily Eastern News (7141)
- Adult (7027)
- BG News (7010)
- Faculty (6313)
- N.M. (6305)
- Mental health (6222)
- Pennsylvania (6209)
- B.G. News (5981)
- Mice (5892)
- Collegeville (5821)
- Middle Aged (5769)
- Students (5680)
- Publication Year
-
- 2026 (48583)
- 2025 (75572)
- 2024 (79511)
- 2023 (77310)
- 2022 (76356)
-
- 2021 (76678)
- 2020 (74484)
- 2019 (65553)
- 2018 (61994)
- 2017 (60656)
- 2016 (57374)
- 2015 (53342)
- 2014 (48962)
- 2013 (45570)
- 2012 (44640)
- 2011 (38421)
- 2010 (35742)
- 2009 (32209)
- 2008 (29304)
- 2007 (26421)
- 2006 (24592)
- 2005 (22437)
- 2004 (20418)
- 2003 (18895)
- 2002 (17894)
- 2001 (16929)
- 2000 (16435)
- 1999 (15086)
- 1998 (14738)
- 1997 (14291)
- Publication
-
- Theses and Dissertations (30811)
- Walden Dissertations and Doctoral Studies (15576)
- Electronic Theses and Dissertations (15545)
- Faculty Publications (14368)
- Faculty, Staff and Student Publications (13689)
-
- Dissertations (12709)
- Session Laws 1951-2000 (12443)
- Faculty Scholarship (10225)
- Spartan Daily (School of Journalism and Mass Communications) (8078)
- Faculty, Staff and Students Publications (7732)
- Daily Mississippian (all digitized issues) (7637)
- Articles (7455)
- Open Access Publications (7412)
- 2020-Current year OA Pubs (7383)
- BG News (Student Newspaper) (7107)
- Santa Fe New Mexican, 1883-1913 (6966)
- Master's Theses (6843)
- Montana Kaimin, 1898-present (6764)
- Theses (6568)
- Chulalongkorn University Theses and Dissertations (Chula ETD) (6481)
- Browse All News (6430)
- Masters Theses (6389)
- The Murray Ledger & Times (6370)
- Honors Theses (5931)
- Doctoral Dissertations and Projects (5824)
- Session Laws 2001-Present (5710)
- USF Tampa Graduate Theses and Dissertations (5473)
- International Nursing Research Congress (INRC) (5316)
- Graduate Theses, Dissertations, and Problem Reports (ETD) (5148)
- Saudi Medical Journal (5073)
- Publication Type
Articles 52831 - 52860 of 1791776
Full-Text Articles in Entire DC Network
Medical Education Conference 2025, Sultan Qaboos University
Medical Education Conference 2025, Sultan Qaboos University
Sultan Qaboos University Medical Journal
No abstract provided.
Towards Resilient Data Governance: An Industry Study On Practitioner Perspectives On The Current State Of Data Governance, Anthony Mazzarella Iii
Towards Resilient Data Governance: An Industry Study On Practitioner Perspectives On The Current State Of Data Governance, Anthony Mazzarella Iii
Theses and Dissertations
Experts agree that data governance is crucial for managing data as an asset, yet in practice, it remains inconsistently defined, unevenly implemented, and poorly understood. Earlier industry studies offered valuable descriptive benchmarks of governance adoption and professional roles, but provided limited theoretical insight and little empirical evidence explaining how governance functions within organizations. Building on this foundation, the current research offers a more substantial and analytically rigorous contribution by transforming descriptive observations into empirical explanations. Through a collaborative academic–industry partnership, the study utilizes a global survey of 565 respondents (348 valid cases) to analyze governance structures, motivations, challenges, and the …
2026 Favorite Foods Festival Participation Packet For Rockingham And Strafford Counties, Caitlin Wollack
2026 Favorite Foods Festival Participation Packet For Rockingham And Strafford Counties, Caitlin Wollack
UNH Cooperative Extension
No abstract provided.
Midweek Memo, Georgia Southern University
Midweek Memo, Georgia Southern University
Midweek Memo
- Applaud
- Remember
- Share
- Experience
- Around the Nest
Anti-Imperialism & Neo-Colonialism, The Philosophical Discussion Group
Anti-Imperialism & Neo-Colonialism, The Philosophical Discussion Group
The Philosopher's Stone
- Anti-Imperialism & Neo-Colonialism
Examining The Impact Of Social Media On The Nutrition Decisions Of College Students And Their Attitudes Toward Nutritional Guidelines, Katlyn Neibaur
Examining The Impact Of Social Media On The Nutrition Decisions Of College Students And Their Attitudes Toward Nutritional Guidelines, Katlyn Neibaur
Undergraduate Honors Theses
Social media is becoming an increasingly popular platform used by young people to garner information, but this information is not always accurate. Understanding the degree of influence social media has on college students’ dietary habits and attitudes toward nutritional guidelines is vital for improving nutrition literacy efforts and creating policies to protect against nutritional misinformation. This study examined the associations between the social media habits of college students, their attitudes toward nutritional guidelines, and their ability to detect nutritional misinformation. A cross-sectional survey was conducted with 457 undergraduate students at Brigham Young University. The content validity of the survey was …
Explainable Ai For Liver Transplant Survival Prediction: Integrating Immunological Mismatch Features, Sourab Shaik
Explainable Ai For Liver Transplant Survival Prediction: Integrating Immunological Mismatch Features, Sourab Shaik
Honors Projects
Liver Transplantations are crucial treatment for end-stage liver disease. However, a persistent deficit of donor organs necessitates maximizing the utility of each available graft to minimize failure rates. We evaluated whether donor–recipient molecular immunogenicity metrics - Electrostatic and Hydrophobic Mismatch Scores (HMS/EMS) and eplet-based counts - improve post–liver-transplant survival prediction. The analytic cohort comprised adult, first time, single-organ deceased-donor transplants drawn from Scientific Registry of Transplant Recipients; follow-up was truncated at five years, and the endpoint was all-cause graft failure (earliest of graft failure or death; otherwise, censored). HLA variables were derived via high- resolution conversion and molecular mismatch computations …
Strategies For Improving Supported Employment Services For Adults With Intellectual And Developmental Disabilities, Janelle Latoya Bailey
Strategies For Improving Supported Employment Services For Adults With Intellectual And Developmental Disabilities, Janelle Latoya Bailey
Walden Dissertations and Doctoral Studies
There is a growing need for supported employment services and improved programming among people with intellectual/developmental disabilities (I/DD). The research question for this study was; what are human service staff and administrators’ experiences and perceptions of what is working well in supported employment programs, and how to improve the services offered to adults with I/DD in a northeastern county? The tenets of Kurt Lewin’s change model form the theoretical framework for the study, to serve as a foundation for effective change. A force field analysis approach was used to gather narrative written data from open ended questionnaire responses to grasp …
Effective Leadership Strategies Used To Retain Volunteers In Nonprofit Organizations, Celine Ejoh Njeck
Effective Leadership Strategies Used To Retain Volunteers In Nonprofit Organizations, Celine Ejoh Njeck
Walden Dissertations and Doctoral Studies
Abstract Nonprofit organizations provide critical services that address social, cultural, and economic needs within communities. Nonprofit leaders who cannot retain volunteers risk reduced organizational capacity, interruptions in program delivery, and weakened ability to achieve program objectives. Grounded in servant leadership theory, the purpose of this qualitative pragmatic inquiry project was to identify and explore the effective strategies nonprofit leaders use to retain volunteers to support their program objectives. Participants were six nonprofit leaders in north Texas who have successfully retained volunteers to support their program objectives. Data was collected using semi structured interviews and a review of publicly available documents …
Social And Contextual Factors Influencing Hypertension Among Latino Men Living In California, Leslie Ivett Ortega
Social And Contextual Factors Influencing Hypertension Among Latino Men Living In California, Leslie Ivett Ortega
Walden Dissertations and Doctoral Studies
Hypertension remains a critical and often silent public health issue that disproportionately affects Latino men in California. This quantitative, retrospective cross-sectional study explored the social and contextual factors influencing hypertension among this vulnerable population. Using the 2019 Behavioral Risk Factor Surveillance System dataset, which included a sample size of 2,060 participants, the study examined the relationship between hypertension and key variables including primary care utilization, health insurance, smoking, physical activity, mental health, and marital status, while controlling for age, education, and income. Guided by the health belief model, binary logistic regression analyses found health insurance and primary care utilization significantly …
An Examination Of Psychosocial Factors Related To Male Serial Killers, Rachael Elizabeth Tubbs
An Examination Of Psychosocial Factors Related To Male Serial Killers, Rachael Elizabeth Tubbs
Walden Dissertations and Doctoral Studies
Historically, studies on serial murderers have not concentrated in depth on analyzing what psychosocial factors are or how they could influence a man to become a serial killer. The focus of this qualitative study was on the psychosocial characteristics of male serial killers that are from, and based in, the United States. Using a case study analysis approach, the life course of serial killers in the FGCU Radford Database was analyzed to identify themes of adverse childhood experiences such as physical, emotional, or psychological abuse; abandonment by parent or guardian; limited or no social bonds; witnessing abuse; and signs of …
Narratives Of Sexual Self-Esteem As A Domain Of Sexual Well-Being In Cisgender Women’S Long-Term Intimate Relationships, Lisa Criswell
Narratives Of Sexual Self-Esteem As A Domain Of Sexual Well-Being In Cisgender Women’S Long-Term Intimate Relationships, Lisa Criswell
Walden Dissertations and Doctoral Studies
Only within the last few decades has female sexual health become a topic of focus for researchers and practitioners to begin focusing on, leading to a gap in research between female sexual health and male sexual health. This has led to lack of knowledge and understanding on female sexual dysfunction and how interventions can effectively address it. An identified gap in knowledge of female sexual health and self-esteem is the lack of understanding of female narratives. This study was developed with the purpose of filling that gap and addressing domains within sexual health and self-esteem through exploration of the narratives …
Hidden Threats In Water: The Global Rise Of Emerging Contaminants, Baljit Singh, Abhijnan Bhat, Gayathree Thenuwara, Kamna Ravi, Azza Silotry Naik, Christine O’Connor, Furong Tian
Hidden Threats In Water: The Global Rise Of Emerging Contaminants, Baljit Singh, Abhijnan Bhat, Gayathree Thenuwara, Kamna Ravi, Azza Silotry Naik, Christine O’Connor, Furong Tian
Research Outputs: 2025-Present
The general spread of water safety awareness and enforcement often masks the escalating risks of emerging contaminants (ECs) that evade standard detection and monitoring techniques. Traditional monitoring infrastructures depend heavily on localized laboratory-based testing, which is expensive, time-consuming, and reliant on specialized infrastructure and skilled personnel. While specific types of ECs and detection technologies have been examined in numerous studies, a significant gap remains in compiling and commenting on this information in a concise framework that incorporates global impact and monitoring strategies. We aimed to compile and highlight the impact ECs have on global water safety and how advanced sensor …
Facilitating Timely Initiation Of Hiv Care Through An Interdisciplinary, Algorithm-Guided Approach, Courtney Harris
Facilitating Timely Initiation Of Hiv Care Through An Interdisciplinary, Algorithm-Guided Approach, Courtney Harris
DNP Projects
ABSTRACT
BACKGROUND: Initiation of antiretroviral therapy (ART) within twenty-four hours of an HIV diagnosis is safe, shortens time to viral suppression, improves retention in care, and contributes to reduced HIV transmission at the community level (Bacon et al., 2021). Despite this evidence, patients across the United States do not universally receive timely HIV care (Bertolino et al., 2023). Barriers to early ART initiation include lack of staff buy-in, logistical challenges, and socioeconomic factors affecting patients (Doshi et al., 2023).
LOCAL PROBLEM: A small HIV care clinic in the southern United States observed a similar discrepancy, noting inconsistent timely initiation of …
The Rising Age Of The First-Time Homebuyer: A Comprehensive Analysis Of Barriers For Emerging Adults, Stephanie Miller
The Rising Age Of The First-Time Homebuyer: A Comprehensive Analysis Of Barriers For Emerging Adults, Stephanie Miller
Honors Projects
The average age of a first-time homebuyer in the United States was 38 years old in 2024. This is a significant increase compared to previous generations, who often achieved homeownership in their late twenties. This project examines structural, economic, and sociological barriers that prevent emerging adults, particularly recent college graduates, from entering the housing market. Through an analysis of national data from the National Association of Realtors, the U.S. Government Accountability Office, and Freddie Mac, this paper examines how inflation, limited housing inventory, stagnant wages, restrictive zoning policies, and increasing debt amounts have had disproportionate effects on young buyers. Regardless …
Influence And Excess: A Study Of Alcohol’S Governmental, Societal, Biochemical, And Enzymatic Impact In The U.S And Other Countries Around The World, Thomas W. Snider
Influence And Excess: A Study Of Alcohol’S Governmental, Societal, Biochemical, And Enzymatic Impact In The U.S And Other Countries Around The World, Thomas W. Snider
Senior Honors Theses
The conduct of the thesis is to explore the intricacies of alcohol consumption. The thesis will outline the history of alcohol and the societal pressures and conduct of drinking with relation to the government. After the history of alcohol has been defined, the thesis will move into the chemistry portion, delineating the absorption, digestion, metabolism, and excretion of alcohol. This is the portion of the thesis that will contain the quantitative data and source material as much research has already been conducted regarding these components of alcohol consumption. The condition of the research is that the data will be collected …
Neighborhood Disorder And Psychosocial Functioning: Evidence Of Resilience Among Racial/Ethnic Minority Groups, Maverick E. Morales
Neighborhood Disorder And Psychosocial Functioning: Evidence Of Resilience Among Racial/Ethnic Minority Groups, Maverick E. Morales
Student Scholar Symposium Abstracts and Posters
Perceived neighborhood disorder has been linked to poor well-being. In the United States, racial/ethnic minorities are more likely to live in disordered neighborhoods than non-Hispanic White residents. However, it is unclear whether this exposure changes the relationship between perceived neighborhood disorder and psychosocial functioning. Racial/ethnic minorities may draw upon sources of resilience (e.g., religiosity/spirituality), protecting them from neighborhood disorder. Using data from the Health and Retirement Study, the present study examined perceived neighborhood disorder and psychosocial functioning (i.e., life satisfaction, anxiety, perceived stress, and loneliness) to test the following hypotheses: (1) higher perceived neighborhood disorder will relate to worse psychosocial …
Exploring The Potential Of Martian Agriculture: Assessing Viability And Nutritional Composition Of Plants Cultivated In Martian Regolith, Abigail Ross
Honors Theses
In addition to sunlight and water, plants can utilize a small number of nutrients from the soil to biosynthesize all the materials that are needed for growth and development. However, plants require an environment where they are able to obtain those nutrients, such as iron, magnesium, potassium, sulfur, and nitrogen. Environmental factors determine the types and accessibility of nutrients available to plants. Plants then take up these nutrients from the soil to aid in biological mechanisms and the synthesis of important molecules needed for growth and development. Ascorbic acid, commonly known as Vitamin C, is a vital molecule that is …
Evaluation Of A Nurse-Led Echo® Education Series: Telementoring Priority Equitable Primary Care, Bettina H. Riley, Emily S. Bentley, Misty Guy, Pam Johnson, Shannon Powell-Lewis, Joyce Pittman, Jo Ann Otts, Katherine Bydalek, Caleb Howard
Evaluation Of A Nurse-Led Echo® Education Series: Telementoring Priority Equitable Primary Care, Bettina H. Riley, Emily S. Bentley, Misty Guy, Pam Johnson, Shannon Powell-Lewis, Joyce Pittman, Jo Ann Otts, Katherine Bydalek, Caleb Howard
Biennial Convention (CONV)
An Extension for Community Healthcare Outcomes (ECHO®) evidence-based global model provided the framework for a nurse-led professional education series focused on priority topics supporting equitable primary care. A Nursing Recruitment and Education to Expand Access to Culturally-Aligned Healthcare (Nursing REEACH) ECHO® was a goal of a Health Resources and Service Administration (HRSA) of the U. S. Department of Health and Human Services grant. The grant provided resources to increase nursing workforce and capabilities in rural and underserved communities through deployments of graduate nurses in mobile clinics. A grant sub-goal was to expand access to evidence-based services in the community through …
Do Community-Engaged Initiatives Promote Mental Health And Well-Being In Under-Resourced Settings?, Muhammad Chutiyami, Natalie Cutler, Sopin Sangon, Tusana Thaweekoon, Patcharin Nintachan, Wilai Napa, Phachongchit Kraithaworn, Jo River
Do Community-Engaged Initiatives Promote Mental Health And Well-Being In Under-Resourced Settings?, Muhammad Chutiyami, Natalie Cutler, Sopin Sangon, Tusana Thaweekoon, Patcharin Nintachan, Wilai Napa, Phachongchit Kraithaworn, Jo River
Biennial Convention (CONV)
Community-engaged initiatives are recognized as promising strategies for addressing disparities in mental health outcomes in resource-constrained settings. An understanding of the scope/effectiveness of these initiatives in diverse contexts remains limited. Our international team systematically examined community-engaged mental health and wellbeing programs in Low-Middle-Income Countries (LMICs) and under-resourced settings in High-Income Countries (HICs), evaluating level of community engagement and impact on mental health outcomes.
Five academic databases were searched for eligible primary studies published in English up to August 2024. Studies involving community members targeting one or more mental health outcomes were included. Data were extracted using a structured tool, quality …
Young Adults' Experiences With Text Messaging Intervention For E-Cigarette Cessation In Rural Areas, Redson Biswick Machongo, Vipavee Thongpriwan, Seok Hyun Gwon, Devon Noonan
Young Adults' Experiences With Text Messaging Intervention For E-Cigarette Cessation In Rural Areas, Redson Biswick Machongo, Vipavee Thongpriwan, Seok Hyun Gwon, Devon Noonan
Biennial Convention (CONV)
Introduction: Electronic Nicotine Delivery Systems (ENDS, commonly known as e-cigarettes) use has increased rapidly among young adults (YAs, 18-24 years) in rural communities. E-cigarette use is a higher risk factor for both cardiovascular and pulmonary diseases. Addressing the disturbing rates of e-cigarette use in YAs requires cessation resources to be available and accessible. Regrettably, rural community residents have limited access to cessation resources. The purpose of this study was to explore YAs' perceptions and experiences engaging in text-message intervention to assist with vaping cessation effectively.
Methods: A qualitative investigation with individual interviews was conducted. Participants (n = 8) were from …
Legal Considerations On Predictive Policing Based On Italian ‘Algorithmic Administration’ Principles, Stefano Rossa
Legal Considerations On Predictive Policing Based On Italian ‘Algorithmic Administration’ Principles, Stefano Rossa
Yearbook of Antitrust and Regulatory Studies
In Beck’s current risk society, the State is faced with a dilemma. To fail before the risk but to keep the sphere of citizens’ rights intact; or not to fail but to restrict fundamental rights? This payoff turns out to be the main issue that juridical reflections on the use of predictive technology tools in the public sector must consider. Policing is an administrative function that is mainly composed of acts of a preventive nature. By using ICT, it is possible to employ AI systems with a very high rate of certainty to ‘predict’ future crime scene. But is it …
2025-12-03 Letter To The Editor: Student Letter To Su Administration Regarding Interim President, Seattle University
2025-12-03 Letter To The Editor: Student Letter To Su Administration Regarding Interim President, Seattle University
The Spectator Online
No abstract provided.
A Curriculum For Teaching English-Speaking Fluency, Jue Xia
A Curriculum For Teaching English-Speaking Fluency, Jue Xia
Master's Projects and Capstones
This field project intends to apply theories of second language acquisition to practical implementations. The purpose of this project is to design a curriculum that teaches speaking fluency to low level English literacy English as a Second Language (ESL) learners. The theoretical frameworks it uses are Stephen Krashen’s Input Hypothesis Theory (Brown 2014, p.288), Barry McLaughlin’s Attention-Processing Model (Brown 2014, p.292), Lev Vigotsky’s Sociocultural Theory (Brown 2014, p.295). Fink’s (2003) Integrated Course Design model gives important insights when designing the curriculum. In the project, the author developed three themed units to teach speaking skills. In each unit, three modules are …
Teaching Dental Public Health Using A Socially Accountable Approach, Anastasios Plessas, Martha Paisi, Nilufar Ahmed, Zoe Brookes, Robert Witton
Teaching Dental Public Health Using A Socially Accountable Approach, Anastasios Plessas, Martha Paisi, Nilufar Ahmed, Zoe Brookes, Robert Witton
Peninsula Dental School
Traditional approaches to dental public health education across Europe remain dominated by lecture-based learning which often fail to cultivate critical reflection on inequities, privilege, and the broader social determinants of oral health. Social accountability has been recognized as core competency for dental graduates, requiring dental professionals to align professional practice with the health needs of communities. Community-engaged education is a promising pedagogical model that situates learning within real-world contexts, fosters empathy, cultural competence, and advocacy skills, and strengthens professional identity formation. This paper discusses the Peninsula Dental School’s innovative model, which integrates community engagement, reflective practice, and interprofessional education within …
Spartan Daily, December 03, 2025, San Jose State University, School Of Journalism And Mass Communications
Spartan Daily, December 03, 2025, San Jose State University, School Of Journalism And Mass Communications
Spartan Daily, 2025
Volume 165, Issue 41
Long-Term Outcomes And Treatment Patterns In Waldenström Macroglobulinemia Patients Who Discontinue Bruton Tyrosine Kinase Inhibitor (Btki) Therapy, Karan L Chohan, Lorenzo Gensini, Sherif Seif, Xiaowen Sun, Lei Feng, Melody R Becnel, Mahmoud M Gaballa, Hans C Lee, Oren Pasvolsky, Krina K Patel, J Christine Ye, Donna M Weber, Robert Z Orlowski, Sheeba K Thomas
Long-Term Outcomes And Treatment Patterns In Waldenström Macroglobulinemia Patients Who Discontinue Bruton Tyrosine Kinase Inhibitor (Btki) Therapy, Karan L Chohan, Lorenzo Gensini, Sherif Seif, Xiaowen Sun, Lei Feng, Melody R Becnel, Mahmoud M Gaballa, Hans C Lee, Oren Pasvolsky, Krina K Patel, J Christine Ye, Donna M Weber, Robert Z Orlowski, Sheeba K Thomas
Faculty, Staff and Student Publications
No abstract provided.
Cdk2 Inhibition Enhances Cdk4/6 Inhibitor Antitumor Activity In Comprehensive Breast Cancer Pdx Model Screen, Nealia C House, Maxine M Chen, Sima Khazaei, Victoria Brown, Philip Ramsden, David H Peng, Sydney Moore, Liang Yuan, Rentian Wu, Fangyang Wang, Linjie Luo, Ningping Feng, Christopher A Bristow, Timothy A Yap, Khandan Keyomarsi, Joseph R Marszalek, Scott Ribich, Mikael L Rinne, Lakshmi B Muthuswamy, Kerrie L Faia
Cdk2 Inhibition Enhances Cdk4/6 Inhibitor Antitumor Activity In Comprehensive Breast Cancer Pdx Model Screen, Nealia C House, Maxine M Chen, Sima Khazaei, Victoria Brown, Philip Ramsden, David H Peng, Sydney Moore, Liang Yuan, Rentian Wu, Fangyang Wang, Linjie Luo, Ningping Feng, Christopher A Bristow, Timothy A Yap, Khandan Keyomarsi, Joseph R Marszalek, Scott Ribich, Mikael L Rinne, Lakshmi B Muthuswamy, Kerrie L Faia
Faculty, Staff and Student Publications
Aberrant cyclin-dependent kinase 2 (CDK2) activity is implicated as a resistance mechanism to CDK4/6 inhibitors (CDK4/6i) in hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) breast cancer. Using preclinical patient-derived xenograft models, the CDK2i + CDK4/6i combination was active broadly across CDK4/6i-resistant and -naïve HR+ and triple-negative breast cancer models. A novel, weighted mRNA expression signature involving CCND1, CCNE1, RB1, and CDKN2A (p16) predicted response to combined inhibition of CDK2 and CDK4/6. Addition of endocrine therapy significantly enhanced antitumor activity in HR+ models, providing preclinical proof-of-concept for the broad antitumor activity of the triple combination. Early clinical data demonstrated …
The Nature And Distribution Of Road Sediment Contaminants In The Greater Las Vegas, Nevada Area, K. J. Gokey, M. Gillis, Kenneth L. Brown, N. Renkes, C. L. Mcleod, M.P.S. Krekeler
The Nature And Distribution Of Road Sediment Contaminants In The Greater Las Vegas, Nevada Area, K. J. Gokey, M. Gillis, Kenneth L. Brown, N. Renkes, C. L. Mcleod, M.P.S. Krekeler
Geology and Environmental Geoscience Faculty Publications
Road sediment is an underutilized medium in the investigation of environmental pollution, yet it serves as both a source and sink for a wide array of pollutants. In urban areas especially, contaminants present within road sediment have the potential to pose human health risks depending on the abundance, chemical, and physical nature of these contaminants as well as the duration (i.e. acute or chronic) of exposure. Las Vegas, Nevada is currently one of the fastest growing urban areas in the United States and is therefore a prime location for the investigation of potential environmental contaminants and pollutants in road sediment. …
Unsaturated Fatty Acid Oil-Based Microdroplets: A Promising Novel Class Of Microdroplets, Ramiz S. Alejilat
Unsaturated Fatty Acid Oil-Based Microdroplets: A Promising Novel Class Of Microdroplets, Ramiz S. Alejilat
Seton Hall University Dissertations and Theses (ETDs)
Droplet-based microfluidics has rapidly advanced numerous fields, including chemistry, biology, materials science, medicine, food science, and cosmetics. In these systems, fluorocarbon oil combined with fluorinated surfactants is the preferred medium for fluid encapsulation, offering exceptional stability and biocompatibility essential for sensitive biological and chemical processes. However, growing concerns about the environmental and biological risks associated with fluorinated chemicals have prompted a search for alternatives.
This study is the first to explore the use of unsaturated fatty acids derived from emu oil for microdroplet formation. We characterized droplet formation based on flow rates and the presence non-fluorinated surfactant at a certain …