Digital Commons Network^™

First-In-Child Phase I Trial Of P-Stat3 Inhibitor Wp1066 In Pediatric Brain Tumor Patients, Robert C Castellino, Hope L Mumme, Andrea T Franson, Bing Yu, M Hope Robinson, Kavita Dhodapkar, Dolly Aguilera, Matthew J Schniederjan, Rohali Keesari, Zhulin He, Manoj Bhasin, Waldemar Priebe, Amy B Heimberger, Tobey J Macdonald

Faculty, Staff and Student Publications

Background: WP1066 is an orally bioavailable, small molecule inhibitor of activated p-STAT3 that has demonstrated preclinical efficacy in pediatric brain tumor models.

Methods: In a first-in-child, single-center, single-arm 3+3 design Phase I clinical trial, ten patients were treated with WP1066 twice daily, Monday-Wednesday-Friday, for 14 days of each 28-day cycle to determine the maximum tolerated dose (MTD)/maximum feasible dose (MFD) of WP1066. Compassionate use treatment with WP1066 in three pediatric patients with H3.3 G34R/V-mutant high-grade glioma (HGG) is also described.

Results: There was no significant toxicity and the MFD was determined to be 8 mg/kg. Treatment-related adverse events were Grade …

Delayed Delivery Of Antibiotics By Ultrasound-Mediated Rupture Of Polylactic Acid Pockets: In Vitro And In Vivo Studies, Selin Isguven Billmyer, Priscilla Machado, Ryan Tomlinson, Lauren J. Delaney, Ji-Bin Liu, Alexander H Harris, Eric Mclaughlin, Noreen J. Hickok, Flemming Forsberg

Department of Radiology Faculty Papers

Surgical site infections are a devastating complication of instrumented orthopaedic surgery, particularly in the spine. Bacterial biofilms, once formed on the implant surfaces, exhibit antibiotic tolerance and immune escape, which lead to treatment challenges. Up to 9% of instrumented spine surgeries result in infection, despite the use of systemic antibiotics and local, powdered antibiotics for prophylaxis. The bacteria that survive the initial prophylaxis may be susceptible to a second, high dose of antibiotic prophylaxis prior to establishing at the site. Hence, we designed a local drug delivery system consisting of polylactic acid (PLA) film pockets that can be noninvasively triggered …

The Moral Crisis Of Maternal Mortality In The Us, Jensen F. Ware

Honors Theses

This thesis argues that the US crisis of maternal mortality is not an unavoidable tragedy, but a moral and policy failure. I argue that maternal well‑being is one of the most important indicators of a society’s overall health. When mothers receive the care, respect, and support they need, it reflects the strength of healthcare systems, the culture, and our commitment to future generations. The continued loss of mothers from preventable deaths reveals a system that fails many women and their families, especially Black women, low‑income women, and those in rural communities. First, I introduce the issue of maternal mortality in …

Quality Improvement (Qi) Project Aimed At Reducing 30-Day Hospital Readmissions For Patients With Congestive Heart Failure (Chf) Through Checklist Implementation, Gary Gutierrez

Seton Hall University Dissertations and Theses (ETDs)

Abstract

Congestive Heart Failure (CHF) remains a leading cause of preventable 30-day hospital readmissions,

especially in outpatient and transitional care settings. This quality improvement (QI) initiative was

launched within a private internal medicine practice in Essex County, New Jersey, to address this issue

by implementing a standardized CHF management checklist. The checklist focused on four key

components: (a) comprehensive medication reconciliation, (b) tailored patient education, (c) timely

follow-up appointments, and (d) improved interdisciplinary communication. By integrating evidence-

based practices into a structured workflow, the QI project aimed to improve care coordination,

empower patients to manage their condition, and reduce preventable …

The Impact Of Social Factors On Vagally Mediated Parasympathetic Activity, Andrew Scot Proctor

Theses and Dissertations

Loneliness and social disconnection are recognized risk factors for morbidity and mortality, yet the psychophysiological pathways remain contested. This dissertation examines how social factors relate to vagally mediated parasympathetic activity indexed by heart rate variability (HRV) and tests whether conversational interventions with a human or a large-language-model (LLM)-based companion can acutely reduce loneliness and enhance connection. Across two university sites (BYU, UCSD), N=297 participants (18-27 years) were randomized to (a) a reciprocal self-disclosure conversation with a trained human confederate, (b) a parallel, vocalized LLM chatbot conversation, or (c) a non-social, vocal reading control. Resting HRV (RMSSD, SDNN, HF-HRV) was recorded …

Paradigm Pivot: Envisioning A New Education System To Cultivate An Era Of Human Intelligence, Heather J. Leslie Phd

Learning Design Center: Staff Scholarship

This think piece proposes a new paradigm for the education system that moves towards more humane practices and away from more mechanistic, standardized practices in order to cultivate intrinsic motivation, authenticity, and the capacity for each person to develop their unique human abilities in the era of artificial intelligence.

Structural Birth Defects And Leukemia Risk In Children With Down Syndrome, Ching-Ju Hsu, Jeremy M Schraw, Sonja A Rasmussen, Tiffany M Chambers, Tania A Desrosiers, Chad D Huff, Amanda E Janitz, Russell S Kirby, Eirini Nestoridi, Wendy N Nembhard, Jason L Salemi, Charles Shumate, Jean Paul Tanner, Mahsa M Yazdy, Michael E Scheurer, Karen R Rabin, Philip J Lupo

Faculty, Staff and Students Publications

Birth defects are associated with increased cancer risk in the general pediatric population, yet their impact on leukemia risk in children with Down syndrome (DS) remains uncertain. We assessed this using data from 26,660 children with DS in the Genetic Overlap Between Anomalies and Cancer in Kids Registry Linkage Study. Among them, 71.9% had at least one major birth defect, predominantly involving the cardiac (64.2%), musculoskeletal (21%), and gastrointestinal systems (6.8%). The cumulative incidence of acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) was comparable in children with and without co-occurring defects. Adjusted hazard ratios (aHR) for ALL and …

Atypical Spindle Cell Lipomatous Tumor: A Scoping Review Of Current Insights Into Diagnosis, Pathogenesis, And Management, Noor Chughtai, Jordan Shelestak, Cortland Brown, Jared Nichols

Student Publications

Atypical spindle cell/pleomorphic lipomatous tumor (ASPLT) is a recently recognized benign adipocytic neoplasm, distinguished by specific histopathological and immunohistochemical features. Although traditionally classified as a tumor of the limbs and limb girdles, emerging evidence suggests a broader anatomic distribution. A systematic review of the literature was conducted using PubMed to identify ASPLT case reports published within the past decade. Cases were included if they had a confirmed ASPLT diagnosis, while reports describing unrelated neoplasms or limited by language barriers were excluded. Thirteen cases met the inclusion criteria. Data on patient demographics, tumor characteristics, immunohistochemical profiles, and diagnostic methodologies were extracted …

Editorial: Advancing Understanding Of Neonatal Bacterial Infections., Susana Chavez-Bueno, Shelley M. Lawrence

Manuscripts, Articles, Book Chapters and Other Papers

No abstract provided.

Enhancing Graduate Employability Through The Role Of The School Career Center (Bursa Kerja Khusus) At Smkn 1 Bandung, Dwi Purwanto, Didik Nurhadi, Widiyanti Widiyanti

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

This study examines the role of the Bursa Kerja Khusus (BKK) in enhancing graduate employability at SMKN 1 Bandung. Using a qualitative descriptive design, data were collected through interviews with BKK staff, teachers, alumni, and industry partners, supported by observations and document analysis. The findings reveal that BKK functions as a strategic bridge between school and industry by providing digital job information services, facilitating structured recruitment processes, and maintaining strong industry partnerships. These practices effectively support graduates’ transition into the workforce. However, challenges persist, particularly related to limited soft skills and occasional mismatches between school competencies and industry demands. Supporting …

The Story Of Albert E. Horsley, James R. Nix

Ellen White Issues Symposium

No abstract provided.

Development Of Contemporary Issues Related To Ellen G. White, Alberto R. Timm

Ellen White Issues Symposium

No abstract provided.

Pxj Volume 12 – Key Theme Summary And Article Index, Patient Experience Journal

Patient Experience Journal

Volume 12 of the Patient Experience Journal showcases a global dedication to advancing human experience in healthcare, illuminating both existing challenges and crucial emerging practices. The content, spanning three issues, emphasizes that improving the human experience is not a temporary initiative but rather the essential foundation for building trust, ensuring safety, facilitating healing, and sustaining organizational resilience. The overarching message of Volume 12 is that human experience is the heart of healthcare. It is actively shaped through shared purpose, design, empathy, communication, and partnership. The journal calls for a future where every voice is heard, every story matters, every …

Effects Of Hambeles (Myrtus Communis L.) Leaf On In Vitro Ruminal Fermentation Parameters, Methane Production And Protozoa Counts, Çağrı Kale, Fatma Özkan, Taylan Aksu, Devrim Saripinar Aksu, Nuriye Tuğba Bingöl, Mehtap Güney, Süleyman Ercüment Önel

The Thai Journal of Veterinary Medicine

Current ruminant nutrition studies are based on improving rumen fermentation to enhance performance and reduce greenhouse gases. For this purpose, the use of herbal-based feed supplements has become widespread. To determine the effects of adding Hambeles (Myrtus communis L.) leaf to some roughage on rumen fermentation parameters by in vitro gas production technique. Corn silage, alfalfa hay and wheat straw were used as roughage. Hambeles leaf was added to roughage at the rate of 0%, 3%, 6%, 9% of the dry matter. According to the data obtained, it was determined that adding 6% and 9% Hambeles leaves to corn …

Core And Characteristic Oral Microorganisms In The Giant Pandas (Ailuropoda Melanoleuca) Suggested Plenty Of Antibiotic Resistance Prevalence: A Mini Review, Han Long, Haifeng Liu, Caiwu Li, Xiaoping Ma, Guangneng Peng, Zhijun Zhong, Chengdong Wang, Ziyao Zhou

The Thai Journal of Veterinary Medicine

The giant panda (Ailuropoda melanoleuca) is a world-recognized rare wildlife endemic to China. Oral microorganisms may cause dental and other systemic diseases. Additionally, antibiotic resistance in this cute mammal may spread widely to travelers. In this mini review, we illustrated the oral core microorganisms of the giant pandas and their characteristics, as well as their prevalence of antibiotic resistance genes. Although there is limited availability in panda sample collection, researchers have made great efforts to find the characteristics of the giant pandas’ oral microbiota, including Enterococcus faecium, Enterococcus faecalis, and Staphylococci, with antibiotic resistance genes optrA …

The Tax Adviser, Volume 3, Number 2, February 1972, American Institute Of Certified Public Accountants

Tax Adviser

No abstract provided.

Index: Subject Index—12 Months Ended January 1972; Author Index—12 Months Ended January 1972, American Institute Of Certified Public Accountants

Tax Adviser

No abstract provided.

Tax Trends, Harry Z. Garian

Tax Adviser

No abstract provided.

Washington Report: Revenue Sharing Or Share The Wealth - It’S On The Way, Gilbert Simonetti Jr.

Tax Adviser

No abstract provided.

Estate Planning: Short-Term Trusts Are Not Dead!, Bernard Barnett

Tax Adviser

No abstract provided.

Index: Subject Index -12 Months Ended December 1971; Author Index -12 Months Ended December 1971, American Institute Of Certified Public Accountants

Tax Adviser

No abstract provided.

And Then There Were Two: Navigating Library Services Through Institutional Change, Joni Addis

South Carolina Libraries

Based on an SCLA conference presentation, this article reflects on one small academic library’s journey through university-wide rightsizing and the impact it had on library services. The loss of positions necessitated across-the-board changes in the division of responsibilities and library operations. In the current climate of higher education in the United States, library staff at other institutions should prepare now for possible staffing challenges in the future. Practical takeaways learned through navigating institutional change are discussed, along with an action plan for library administrators and leaders.

Sir Sultan Mahomed Shah Aga Khan Iii - One Of Muslim World's Most Visionary And Influential Leaders

University anniversary celebration materials

No abstract provided.

Artificial Intelligence And The Translation Of Culture-Specific Terms On Arabic Monolingual Signs At Aseer Tourist Sites, Saudi Arabia, Ali Mohammad A. Alghamdi, Bakr Bagash Mansour Ahmed Al-Sofi

UB Journal for Humanities

Artificial intelligence (AI) tools are increasingly used in various fields, including the translation of signs within linguistic landscapes. This field-based study investigates the performance of AI tools, namely, Google Gemini and DeepSeek, in translating culture-specific terms (CSTs). To this end, Arabic monolingual signs at tourist sites in Aseer region in Saudi Arabia were documented and a comparative content analysis approach was employed to evaluate the accuracy, cultural sensitivity, and contextual relevance of the AI-generated translations. These translations were then compared to human translations using the same criteria designed for independent human evaluation. The findings indicated that Gemini consistently outperformed DeepSeek …

Filling In The Gaps: How The Equal Employment Opportunity Commission Can Enhance Protections For H-1b Visa Holders, Mahi Patel

Northwestern Journal of Law & Social Policy

H-1B Specialty Occupations Visas allow numerous foreign nationals to obtain a pathway for entry into the United States through their hard-earned efforts and specialized skills. After meeting stringent requirements and completing complex processes, holders of H-1B visas may begin working in America. Unfortunately, when these individuals come to the land of opportunity, they encounter a harsh reality of employment: the incessant discriminatory abuse of H-1B visa holders by their employers. H-1B employees endure severe working conditions, long hours, unattainable deadlines, wage disparities, and racial biases as they navigate an unknown nation. Employers tend to exploit H-1B workers because these visa …

Disclosures, Disclaimers, And Disinformation Advertising, Areeb Asif

Northwestern Journal of Law & Social Policy

Every regular internet user in the United States has been exposed to fake news at some point. Most of them, if not all, would agree that this problem needs a solution. Nevertheless, even as fake news has taken on unforeseen prominence in recent years, very little concrete action has been taken to curb its impact on American society. Some scholars have chalked this up to the Supreme Court’s expansive conception of the First Amendment, which makes it incredibly challenging to regulate political speech. Others posit that the problem is Section 230, which allows platforms to profit from fake news without …

Acute Effects Of Multi-Joint Eccentric Exercise On Lower-Extremity Muscle Activation Measured During Land And Water Walking, Brayden Worley, Brennan J. Thompson, Jon Carey, Talin Louder

Kinesiology and Health Science Student Research

Falls are a leading cause of injury and loss of independence in older adults, often linked to deficits in lower-limb muscle function and gait mechanics. Eccentric exercise can improve muscular resilience, while aquatic walking offers a safe, supportive environment to retrain gait; however, little is known about how these modalities interact at the neuromuscular level. This study compared lower-limb muscle activation during gait on land and in water, before and after an acute bout of eccentric exercise, in healthy young adults. Surface electromyography was collected from the tibialis anterior (TA), gastrocnemius medialis (GM), vastus lateralis (VL), and biceps femoris (BF) …

Personal Healthcare Networks: Integrative Review Of Patient-Centered Social Network Analysis Studies, Tyler Gaedecke, Sarah Harkins, Walter Bockting, Kasey Jackman

Biennial Convention (CONV)

Background: Social network analysis is an interdisciplinary social science methodology used to investigate relationships between individuals, communities, and systems. In health research, it has often been used to research interpersonal dynamics on healthcare teams. However, it is infrequently applied to the patient perspective of those teams. One kind of social network analysis, the “personal” network, collects data based on one’s own perception of their connections and relationships. This methodology may be useful to gain the patient’s perspective on accessing healthcare services.

Purpose: To describe and evaluate empirical research using social network approaches to capture the patient perspective about healthcare teams’ …

The Chemistry Of Color: A Comparative Analysis Of Natural And Synthetic Dyes In Textile Application, Caitlyn Pinaga Cpht

Honors Program Theses and Research Projects

The Chemistry of Color: A Comparative Analysis of Natural and Synthetic Dyes in Textile Application examines how color functions at the intersection of chemistry, culture, and environmental responsibility. This project traces the evolution of dyeing from ancient natural pigment traditions, rooted in ecological knowledge, agricultural practices, and cultural identity, to the industrial rise of synthetic dyes, whose laboratory precision enabled unprecedented consistency, brightness, and global textile expansion. Through experimental swatch analysis, the study compares the behavior of natural dyes derived from plants and food sources with modern fiber-reactive and synthetic dye classes on a range of fibers including cotton, bamboo …

Tonight’S Top Story: Analyzing English And Spanish-Language National And Local Newscasts For Content Differences, Esteban N. Serrano

Honors Program Theses and Research Projects

Spanish-language media alongside its equivalent English-language counterpart, assumingly operate with reporting facts truthfully. However, no studies have compared the accuracy of equitable reporting between English and Spanish-language news, particularly television newscasts. Limited existing research claims that differences, such as the structure of news stories and their placement in a broadcast, may skew a narrative for those who prefer to absorb Spanish-language news in comparison to those who absorb English-language news. In this study, through use of mixed methods, U.S. market’s English and Spanish broadcast news-affiliated stations are examined to draw conclusions on whether or not there are differences in news …