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Ole Miss Student Joins Elite Cohort Of Newman Civic Fellows, Marisa C. Atkinson Dec 2025

Ole Miss Student Joins Elite Cohort Of Newman Civic Fellows, Marisa C. Atkinson

University of Mississippi News

OXFORD, Miss. – University of Mississippi junior Emerson Morris takes pride in her community and home state, and she hopes to channel her passion to one day advocate for underserved regions of the South.


Give Me Your Hungry, Your Poor: How Welfare Restrictions Perpetuate Recidivism, Kaitlyn Hammond Dec 2025

Give Me Your Hungry, Your Poor: How Welfare Restrictions Perpetuate Recidivism, Kaitlyn Hammond

Vanderbilt Social Justice Reporter

No abstract provided.


Tennessee’S Families Rights And Responsibilities Act: A Risky Gamble With Adolescent Health And Safety, Oluwafunmilayo Oguns Dec 2025

Tennessee’S Families Rights And Responsibilities Act: A Risky Gamble With Adolescent Health And Safety, Oluwafunmilayo Oguns

Vanderbilt Social Justice Reporter

No abstract provided.


Looking Down The Road: The First Steps To A Public Interest Law Career, Amy Leipziger Dec 2025

Looking Down The Road: The First Steps To A Public Interest Law Career, Amy Leipziger

Vanderbilt Social Justice Reporter

No abstract provided.


April 4, 1968: A Law Student’S Night In The Memphis Jail, Alex Jay Hurder Dec 2025

April 4, 1968: A Law Student’S Night In The Memphis Jail, Alex Jay Hurder

Vanderbilt Social Justice Reporter

No abstract provided.


Rapid Detection Of Chicken Residues On Poultry Plant Surfaces Using Color And Fluorescence Spectrometry, Clark Griscom, Dongyi Wang, Corliss A. O'Bryan, Rimmo Room, Philip G. Crandall Dec 2025

Rapid Detection Of Chicken Residues On Poultry Plant Surfaces Using Color And Fluorescence Spectrometry, Clark Griscom, Dongyi Wang, Corliss A. O'Bryan, Rimmo Room, Philip G. Crandall

Food Science Faculty Publications and Presentations

Color and fluorescence spectrometry were evaluated as rapid, objective tools for verifying the cleanliness of poultry-processing food-contacting surfaces contaminated with a model chicken solution across six common materials. Both techniques detected chicken residues at dilutions several orders of magnitude below human visual and olfactory thresholds, with stainless steel and blue plastic yielding the largest color differences between clean and contaminated states and fluorescence measurements remaining highly sensitive on all tested surfaces. Representative limits of detection were on the order of 1:50-1:100 dilution of chicken residue for color measurements on most surfaces and approximately 1:50 for fluorescence measurements, compared with human …


Applied Methods For Matching Implementation Strategies To Determinants: A Scoping Review Of Scientific And Grey Literature, And Qualitative Exploration Of Practice Experiences, Christiaan Vis, Leti Van Bodegom-Vos, Bethany Hipple-Walters, Byron J Powell, Erwin Ista, Femke Van Nassau Dec 2025

Applied Methods For Matching Implementation Strategies To Determinants: A Scoping Review Of Scientific And Grey Literature, And Qualitative Exploration Of Practice Experiences, Christiaan Vis, Leti Van Bodegom-Vos, Bethany Hipple-Walters, Byron J Powell, Erwin Ista, Femke Van Nassau

2020-Current year OA Pubs

BACKGROUND: Tailored implementation addresses the inherent dynamic complexity and heterogeneous nature of implementation practice. In general, tailored implementation involves setting implementation objectives, identifying determinants, matching strategies to those determinants, and developing an evaluation plan. How matching a specific implementation strategy to a determinant is done remains largely unknown. This study aimed to provide an overview of methods for matching strategies that have been applied in research and practice.

METHODS: A scoping review of scientific and grey literature was conducted. A Rapid Assessment Procedure approach guided the design and analysis. Five online scientific bibliographic databases and various Dutch websites were searched …


Shaping Oman’S Child Health Future By 2040: Key Projections For Population And Workforce In Developmental-Behavioural Paediatrics, Watfa Al-Mamari, Ahmed B. Idris, Rola Al-Balushi, Kamila Al-Alawi, Saquib Jalees, Ahmed Al-Saidi Dec 2025

Shaping Oman’S Child Health Future By 2040: Key Projections For Population And Workforce In Developmental-Behavioural Paediatrics, Watfa Al-Mamari, Ahmed B. Idris, Rola Al-Balushi, Kamila Al-Alawi, Saquib Jalees, Ahmed Al-Saidi

Sultan Qaboos University Medical Journal

No abstract provided.


Using Ecorevelatory Design And Landscape Biography To Promote Ecological Literacy In Menomonee Valley, Milwaukee, Wi, Usa, Jennifer Engelke Dec 2025

Using Ecorevelatory Design And Landscape Biography To Promote Ecological Literacy In Menomonee Valley, Milwaukee, Wi, Usa, Jennifer Engelke

Cities and the Environment (CATE)

Menomonee Valley in Milwaukee, Wisconsin, USA, has undergone a remarkable transformation from a defunct brownfield site into a vibrant landscape of community parks within a revitalized industrial corridor. This change was driven by ecological restoration, stormwater management, and renewed connections to the Menomonee River. Central to this transformation was the use of ecorevelatory design, which draws on historical narratives and site-specific stories to highlight the presence and importance of more-than-human elements such as water, vegetation, and wildlife. To assess how contemporary users engage with these ecological features, the study employed stakeholder interviews, intercept surveys, and site observations. These methods explored …


Trematodes Detected In An Exotic Population Of Red Swamp Crayfish From An Urban Storm Drain In Los Angeles, Jason M. Post, Emily S. Bailey, Rachael J. Post Dec 2025

Trematodes Detected In An Exotic Population Of Red Swamp Crayfish From An Urban Storm Drain In Los Angeles, Jason M. Post, Emily S. Bailey, Rachael J. Post

Cities and the Environment (CATE)

The red swamp crayfish, Procambarus clarkii is an exotic aquatic crustacean with global prevalence. Native to the Southeastern United States, this species has been introduced for aquaculture as it is a popular food fishery resource. A well-documented host for trematodes, P. clarkii is a known vector for parasitic, fungal, and viral infections. Procambarus clarkii has demonstrated the ability to consume exotic snails such as Melanoides tuberculata as a means of controlling snail-borne infections. In this study, an isolated exotic P. clarkii specimen was collected from an urban waterway in Los Angeles, California adjacent and draining into the largest remaining wetland …


The Ascot App – A Plant Tracking Smartphone Tool For Field-Based Community Science, Demian A. Willette, Aaron W. Floreani, Stephanie A. Flores, Milla P. Markovic, Coby T. Sanders, Evan Yu, John David N. Dionisio Dec 2025

The Ascot App – A Plant Tracking Smartphone Tool For Field-Based Community Science, Demian A. Willette, Aaron W. Floreani, Stephanie A. Flores, Milla P. Markovic, Coby T. Sanders, Evan Yu, John David N. Dionisio

Cities and the Environment (CATE)

Urban tree planting efforts have accelerated globally, but systematic monitoring of planted trees, particularly of survivorship and growth, lags behind. To help address this challenge, we developed and implemented the Ascot App, a free, mobile-based tool designed to streamline citizen science data collection in urban habitat restoration projects. Deployed at a Miyawaki-style microforest in Ascot Hills Park, Los Angeles, the app enables volunteers with minimal training to scan QR-coded tags on seedlings and submit standardized, timestamped plant health data via an intuitive interface. The app reduces user error through simplified prompts and integrates directly with a web-based administrative portal for …


Why Do People Use Rat Poison To Manage Rats? A Mixed Methods Study In A Large American City, Maureen H. Murray, Danielle German, Jacqueline Y. Buckley, Seth B. Magle, Kaylee A. Byers Dec 2025

Why Do People Use Rat Poison To Manage Rats? A Mixed Methods Study In A Large American City, Maureen H. Murray, Danielle German, Jacqueline Y. Buckley, Seth B. Magle, Kaylee A. Byers

Cities and the Environment (CATE)

Commensal rats are managed worldwide using rat poisons known as anticoagulant rodenticides (ARs). ARs are a global health and conservation issue as they sicken and kill non-target animals that consume bait or poisoned rats. The public can use AR bait to manage rats without oversight, and so understanding why people use ARs is critical to reducing public use of, and demand for, ARs. We used a sequential explanatory mixed methods approach to examine 1) urban residents’ perceptions and use of rat poison, 2) drivers of rat poison use, and to 3) describe the reasons that poison was used. We surveyed …


Exploring The Individual Relationships Of Mothers' And Fathers' Parenting Styles With Emerging Adults' First-Term Gpa, Tiffany Fox Okeke Dec 2025

Exploring The Individual Relationships Of Mothers' And Fathers' Parenting Styles With Emerging Adults' First-Term Gpa, Tiffany Fox Okeke

Theses and Dissertations

Parenting styles have most often been studied through the lens of adolescent academic outcomes but less is known about how mothers' and fathers' parenting styles influence academic performance separately, especially during the critical transitionary period to post-secondary education. This study examines how mothers' and fathers' parenting styles distinctly shape emerging adults' first-term academic outcomes during their postsecondary education, with a focus on the dimensions of parental warmth and control. The study uses the National Longitudinal Survey of Youth 1997 dataset and the NLSY97 Post-Secondary Transcript Data focusing on the 1997-2005 cohorts (N=3,478) along with OLS regression analyses to predict emerging …


A Comprehensive Study Of Integration And Alternatives For Concrete In The Construction Industry, Saee Sawlikar Dec 2025

A Comprehensive Study Of Integration And Alternatives For Concrete In The Construction Industry, Saee Sawlikar

Theses

Concrete dominates the building industry as a construction material, frequently used due to its versatile, enormous application properties and the flexibility it offers. When just traditional concrete is considered, it contributes to only 8% of the total global warming potential. However, due to its countless vast applications, it’s energy and emissions consumption is up to roughly 35% and 38% respectively when compared with other industries. The study focuses on proposing three alternative low-carbon concrete materials with modified component chemical properties with reference to concrete itself and will test if any material could replace and surpass the benefits offered by concrete …


Relationship Between Muscle Activation And Kinematic Features During Baseball Pitching, Maxwell Skene Dec 2025

Relationship Between Muscle Activation And Kinematic Features During Baseball Pitching, Maxwell Skene

Theses

Background: Baseball pitching is a biomechanically complex, high-velocity movement that places substantial demands on the upper extremity. Inefficient coordination between muscle activation and kinematic sequencing has been associated with reduced performance and increased injury risk, particularly at the shoulder and elbow. However, the integrated relationship between muscle activation patterns and three-dimensional kinematic features during pitching is not well-documented. Purpose: The purpose of this study was to examine the relationship between throwing-arm muscle activation patterns and three-dimensional kinematic characteristics during fastball pitching, with particular emphasis on segmental accelerations, proximal–distal sequencing, and the directional structure of movement quantified using Relative Dimensional Contribution …


Matter Of Mantilla V. New York City Dept. Of Hous. Preserv. & Dev. Dec 2025

Matter Of Mantilla V. New York City Dept. Of Hous. Preserv. & Dev.

All Decisions

In this CPLR article 78 proceeding, the Court of Appeals affirmed the denial of a tenant's succession rights to a deceased brother's Mitchell-Lama apartment. The landlord (HPD) found the tenant failed to prove primary residency for the required one-year period prior to the brother's death, despite being an eligible family member and listed on income affidavits. While the tenant presented some evidence like SNAP correspondence and power of attorney over the brother's bank account, the Court held the agency had a rational basis for concluding this was insufficient. The Court emphasized its deferential standard of review for administrative determinations, upholding …


Spatial Conversations: Opportunities To Share Geographic Knowledge, L. Jesse Rouse, Barbara L. Maclennan, Susan J. Bergeron, H. Franklin Lafone Dec 2025

Spatial Conversations: Opportunities To Share Geographic Knowledge, L. Jesse Rouse, Barbara L. Maclennan, Susan J. Bergeron, H. Franklin Lafone

Anthropology and Geography

For more than twenty years geographers have taken advantage of “new media” to share information, make connections, and expand the “spatial conversation.” As blogs opened the door for informal self-publishing and communicating about narrow, focused topic areas, geographers began to use emerging media platforms to present ideas to a broader audience, more quickly and interactively, as new data and technologies became available. Audio podcasts and videos broadened the platforms for dissemination and provide a greater level of immersion through digital media. Between the open publishing and subscription opportunities, and interaction provided through comments and social media engagement, a dialectic was …


Investigating The Regulatory Impact Of Non-Coding Rnas On Meis1, Salma Fahim Dec 2025

Investigating The Regulatory Impact Of Non-Coding Rnas On Meis1, Salma Fahim

Theses and Dissertations

Myeloid ecotropic virus insertion site 1 (MEIS1) is a transcription factor involved in a myriad of functions such as hematopoiesis, cardiac regeneration, cell cycle progression, cell proliferation, and limb and organ development. Precise control of MEIS1 expression and function is essential for maintaining cellular homeostasis and preventing pathological conditions including cancer. Emerging evidence suggests that non-coding RNAs (ncRNAs) play a significant role in fine-tuning MEIS1 activity. Unmasking these regulatory mechanisms could provide potential therapeutic strategies for conditions where MEIS1 is aberrantly expressed. The present dissertation presents a comprehensive overview of current knowledge on MEIS1, synthesizing findings from the literature to …


Staff Education To Improve Patient Medication Adherence For Schizophrenia Using Long-Acting Injectables, Adela Ghogomu Dec 2025

Staff Education To Improve Patient Medication Adherence For Schizophrenia Using Long-Acting Injectables, Adela Ghogomu

Walden Dissertations and Doctoral Studies

This doctoral project was conducted as a staff education initiative based on a comprehensive literature review that emphasized the importance of staff education in improving healthcare outcomes. The practice problem identified was a lack of staff knowledge and education regarding long-acting injectables (LAIs) in clients with schizophrenia, which contributed to inconsistent support for client medication adherence. It was essential to address this issue because nurses play a crucial role in medication management, patient education, and adherence support. The practice-focused question explored was: Will staff education regarding the use of long-acting injectables in clients with schizophrenia to enhance medication adherence improve …


Teachers’ Perceptions Of Employer-Provided Afterschool Childcare As A Retention Strategy: A Herzberg-Informed Qualitative Case Study, Lakinsha R. Swinton Dec 2025

Teachers’ Perceptions Of Employer-Provided Afterschool Childcare As A Retention Strategy: A Herzberg-Informed Qualitative Case Study, Lakinsha R. Swinton

Walden Dissertations and Doctoral Studies

Teacher retention has been a growing issue, as the rate of teacher vacancies has continued to increase after the COVID-19 pandemic. The increase in teacher vacancies after the pandemic highlighted the importance of retaining and attracting highly qualified teachers for schools and school districts. A coastal South Carolina school district had been providing employee support services to retain current staff and create a competitive advantage over other school districts in attracting new staff. The purpose of this generic qualitative study is to examine the perception of classroom teachers regarding the efficacy of free afterschool childcare as an employee support service …


A Comprehensive Review Of Dental Diseases Detection And Classification Based On Artificial Intelligence Techniques, Nermeen N. Noaman, Yasmin M. Alsakar, Naira E. Elazab, Waleed M. Mohamed, Mohamed E. Ezzat, Mohammed M. Elmogy Dec 2025

A Comprehensive Review Of Dental Diseases Detection And Classification Based On Artificial Intelligence Techniques, Nermeen N. Noaman, Yasmin M. Alsakar, Naira E. Elazab, Waleed M. Mohamed, Mohamed E. Ezzat, Mohammed M. Elmogy

Mansoura Engineering Journal

In dentistry, many diseases, such as gum, cavities, and oral cancer, affect people of all ages. Early treatment and diagnosis are crucial for minimizing dental diseases' effect on overall health and saving money in the long run. Traditional dental diagnosis methods, such as manual probing and visual inspection, are time-consuming and can be subject to human errors. Hence, a computer-aided diagnosis system based on computer vision and artificial intelligence (AI) techniques is needed. The considerable progress in computer vision and AI techniques offers many possibilities in dental diagnosis based on dental X-ray imaging modalities. Dental X-rays are used to diagnose …


Child Maltreatment And Recidivism: Do Maltreatment Patterns Influence General And Violent Reoffending?, Nan Li, Matt Shelton, Elena L. Grigorenko Dec 2025

Child Maltreatment And Recidivism: Do Maltreatment Patterns Influence General And Violent Reoffending?, Nan Li, Matt Shelton, Elena L. Grigorenko

Psychological Science Faculty Publications

This study examined whether patterns of maltreatment predicted reoffending among 5,194 justice-involved youth (JIY) from a large Texas juvenile probation department. Using latent class analysis on five maltreatment types (physical abuse, emotional abuse, sexual abuse, neglect, and exposure to domestic violence), we empirically identified three classes: “Poly-victimization” (17.8%; high across all types), “Psychological Maltreatment” (15.3%; high emotional abuse and neglect), and “Low Maltreatment” (66.9%; low/moderate across types). JIY in the “Poly-victimization” and “Psychological Maltreatment” classes were more likely to engage in general and violent reoffending within 1 year controlling for covariates. These findings highlight the varying importance of different maltreatment …


Pooled Randomised Quartet Trials Assessing Effectiveness Of A Single Pill For Hypertension, Simone Marschner, Mark D Huffman, Desi Quintans, Jody Ciolino, Abigail Baldridge, Danielle Lazar, Emily R Atkins, Graham S Hillis, Mark R Nelson, Markus Schlaich, Anthony Rodgers, Clara K Chow Dec 2025

Pooled Randomised Quartet Trials Assessing Effectiveness Of A Single Pill For Hypertension, Simone Marschner, Mark D Huffman, Desi Quintans, Jody Ciolino, Abigail Baldridge, Danielle Lazar, Emily R Atkins, Graham S Hillis, Mark R Nelson, Markus Schlaich, Anthony Rodgers, Clara K Chow

2020-Current year OA Pubs

BACKGROUND: Hypertension is a major cause of premature death worldwide, controlled by only one in five adults. Two trials (Australia and USA) found a single quadpill containing a quarter dosage of four classes of medication effective in reducing blood pressure (BP) among participants with hypertension. By pooling these trials, we can estimate the overall benefit of the quadpill and its heterogeneity across subgroups and two important barriers for BP control: clinician medication inertia and participant medication adherence.

METHODS: In a prespecified pooled individual participant data analysis of two QUARTET randomised, multicentre, double-blinded trials in people with hypertension using ≤1medication, quadpill …


Presence Of Eosinophils May Represent An Earlier Stage In Achalasia Pathogenesis, Andrea Costantini, Chandra Prakash Gyawali, Francesca Forattini, Valentina Angerilli, Matteo Ghisa, Luca Provenzano, Giovanni Capovilla, Loredana Nicoletti, Michele Valmasoni, Matteo Fassan, Edoardo Vincenzo Savarino, Renato Salvador Dec 2025

Presence Of Eosinophils May Represent An Earlier Stage In Achalasia Pathogenesis, Andrea Costantini, Chandra Prakash Gyawali, Francesca Forattini, Valentina Angerilli, Matteo Ghisa, Luca Provenzano, Giovanni Capovilla, Loredana Nicoletti, Michele Valmasoni, Matteo Fassan, Edoardo Vincenzo Savarino, Renato Salvador

2020-Current year OA Pubs

BACKGROUND: Intraepithelial eosinophils have been described in patients with esophageal motor disorders. Conversely, motor disorders and even achalasia have been reported in patients with eosinophilic esophagitis (EoE).

OBJECTIVES: This prospective study aimed to further investigate the association between eosinophilia and achalasia.

DESIGN: This is a prospective study.

METHODS: A series of 30 consecutive treatment-naïve achalasia patients (mean age: 45.5 years, 53% female) undergoing laparoscopic myotomy were prospectively enrolled. Preoperative demographic and clinical data, radiological findings, and high-resolution manometry (HRM) features were collected. Patients underwent upper endoscopy with biopsy sampling before surgery, and two samples of distal esophageal muscle were obtained …


Limited Agreement On Acl Tear Location Between Arthroscopy And Mri: A Prospective Evaluation, Richard Silverman, Derrick M Knapik, Matthew V Smith, Jonathan C Baker, Kelby Napier, Matthew J Matava, Robert H Brophy Dec 2025

Limited Agreement On Acl Tear Location Between Arthroscopy And Mri: A Prospective Evaluation, Richard Silverman, Derrick M Knapik, Matthew V Smith, Jonathan C Baker, Kelby Napier, Matthew J Matava, Robert H Brophy

2020-Current year OA Pubs

BACKGROUND: Renewed interest in anterior cruciate ligament (ACL) preservation has led to increased focus on tear location within the knee joint in treatment decisions, with primary ACL repair reserved for proximal tears. Retrospective studies have reported varying tear locations in adults when assessed on magnetic resonance imaging (MRI), with few studies comparing tear location on MRI versus intraoperative findings.

PURPOSE: To prospectively determine the distribution of ACL tear location assessed on MRI versus intraoperative evaluation to test the hypothesis that < 15% of ACL tears are proximal type avulsions.

STUDY DESIGN: Cohort study (Diagnosis); Level of evidence, 2.

METHODS: A total of 174 patients with clinically confirmed full-thickness ACL …


Estoppel Without Regard To Equity? The Puzzling Omission Of Promissory Estoppel’S Inequity Condition In Canada, Marcus Moore Dec 2025

Estoppel Without Regard To Equity? The Puzzling Omission Of Promissory Estoppel’S Inequity Condition In Canada, Marcus Moore

All Faculty Publications

Promissory estoppel plays an important role in enabling the enforcement of promises not made for consideration in cases where the promise was intended to and did induce a party to change its position in regard to preexisting legal rights. However, Canadian law on estoppel has been plagued by confusion and misunderstanding. This article addresses the internationally notable absence of an inequity requirement from promissory estoppel in Canada. The requirement’s absence is peculiar, in that estoppel’s very foundation is in equity, and it must assure that its effect is indeed equitable. Drawing on the Supreme Court of Canada’s decision in Trial …


Omics Approaches To Understand Cardiovascular Disease, Zeeshan Ahmed, Goo Jun Dec 2025

Omics Approaches To Understand Cardiovascular Disease, Zeeshan Ahmed, Goo Jun

Faculty, Staff and Student Publications

Omics approaches have emerged as indispensable tools in unravelling the intricate molecular landscape of cardiovascular disease (CVD) by providing comprehensive insights into the underlying mechanisms driving CVD pathogenesis, progression, and response to therapy. Integrative omics approaches further enhance our understanding by integrating multi-omics data to explain complex molecular networks and identify novel disease pathways. In this collection of BMC Cardiovascular Disorders, we invited submissions on omics approaches to investigate and understand CVD. Successfully achieving the goals of this collection, we were able to publish some interesting and impactful research articles after a rigorous peer review process.


Chronic Absenteeism: A Case Study In A Central Virginia High School Investigating Student Habits And Potential Interventions, Ronald R. Proffitt Dec 2025

Chronic Absenteeism: A Case Study In A Central Virginia High School Investigating Student Habits And Potential Interventions, Ronald R. Proffitt

Graduate Dissertations and Theses

Abstract

The purpose of this single case study was to discover and determine the contributing factors for chronic absenteeism for high school students at a rural Central Virginia high school in order to discover potential solutions to increase attendance and to combat chronic absenteeism. An additional factor considered was habits that may have formed during the COVID-19 pandemic, which may have led to an increase in chronic absenteeism rates. The theory that guided this study was Bronfenbrenner’s (1979) Ecological Systems Theory, as it directly addressed how a child relates and reacts to their environments based upon their interactions. The participants …


Wild Robots: Humans, Wilderness, And Technology In Becky Chambers’ Monk And Robot Series, Melissa Moore Dec 2025

Wild Robots: Humans, Wilderness, And Technology In Becky Chambers’ Monk And Robot Series, Melissa Moore

Honors Theses

As technology advances and the environment deteriorates, the way people view the relationships between technology, wilderness, and humans becomes essential for society to move forward. To investigate perceptions about technology’s place in an environmentally conscious society, this project examines manifestations of wilderness/wildness and technology in Becky Chambers’ Monk and Robot series through the lens of ecocriticism. Using Timothy Morton's concept of the ecological thought as a framework for analysis, the circumstances present in the novel suggest that the triangle separating humans, wilderness, and technology has actually collapsed, replaced by an enmeshment of technology, wilderness, and humanity.


Transposable Element-Derived Mir-28-5p And Mir-708-5p: Exploring Potential Roles In Lung Cancer, Sergiu Chira, Cornelia Braicu, Stefan Strilciuc, George A Calin, Ioana Berindan-Neagoe Dec 2025

Transposable Element-Derived Mir-28-5p And Mir-708-5p: Exploring Potential Roles In Lung Cancer, Sergiu Chira, Cornelia Braicu, Stefan Strilciuc, George A Calin, Ioana Berindan-Neagoe

Faculty, Staff and Student Publications

Background: Transposable elements are normally silenced by epigenetic mechanisms; however, during malignant transformation, epigenetic alterations enable transposons to produce functional molecules like miRNAs. Among these, LINE-2 (L2) elements can generate miRNAs capable of regulating key genes, including tumor suppressors. Two L2-derived miRNAs, miR-28 and miR-708, have been linked to lung cancer, yet the mechanisms underlying their dysregulation remain poorly understood. Our study reveals how genomic context contributes to aberrant gene expression through comprehensive bioinformatic analyses.

Methods: Using bioinformatics analysis, we evaluated the expression of miR-28 and miR-708 in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) datasets from TCGA. …