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Articles 49801 - 49830 of 1791780
Full-Text Articles in Entire DC Network
Innocent Until Proven Guilty, Disenfranchised All The Same: Hidden Voter Suppression Within American Jails, Kennedy Hill
Innocent Until Proven Guilty, Disenfranchised All The Same: Hidden Voter Suppression Within American Jails, Kennedy Hill
Arkansas Law Review
Jails throughout the United States hold thousands of legally eligible voters who have not been convicted of a crime While those convicted of felonies are often statutorily disenfranchised, pretrial detainees retain their civil rights—including the right to vote. In theory, this should guarantee them a voice. In practice, pretrial detention operates like a legal disqualification. Without meaningful enforcement mechanisms, the right to vote becomes hollow.
This Comment argues that implementing a national standard based on the proactive policies of Massachusetts and Nevada will ensure accessible voting for pretrial detainees. To build that argument, this Comment first explores the low level …
Workplace Retaliation And The Intersection Of Protected Conduct And Job Performance, Chris M. Schmidt
Workplace Retaliation And The Intersection Of Protected Conduct And Job Performance, Chris M. Schmidt
Arkansas Law Review
A host of statutory schemes seek to ensure equal employment opportunities in the United States by eradicating workplace discrimination (“EEO laws”). Consider two foundational pillars necessary for these EEO laws to strike the desired balance between individual rights and workplace efficiency. First, employees require robust protection from retaliation if they engage in protected conduct—for example, by reporting perceived discrimination. Second, employers can—and ideally, should—make employment decisions based on how an employee performs the job.
The interests in robust protection and performance-based decision-making serve the purposes of our EEO laws and are well-established. Rarely do they conflict (to the contrary, they …
Conservatorship: An Enabler Of Involuntary Servitude, Jesse Long
Conservatorship: An Enabler Of Involuntary Servitude, Jesse Long
Arkansas Law Review
What happens when the conflict of interest relates to the conservatee’s substantial talents and their potential earnings? In this circumstance, a conservator has a perverse incentive to profit off of and coerce their conservatee into labor which serves to benefit the conservator—a kind of involuntary servitude that would seem to implicate the plain text of the Thirteenth Amendment of the United States Constitution.
This Note proceeds in three parts. Part I describes the history of conservatorships, why they were created, and the problematic issues that have arisen from the conservatorship system. Part II analyzes how the lack of meaningful judicial …
The Kids Aren’T Alright, Amy B. Levin
The Kids Aren’T Alright, Amy B. Levin
Arkansas Law Review
It is not new that students struggle in law school. Research has shown for decades that, while students generally begin law school with healthy well-being, the competitive nature of law school combined with the stress of the Bar and securing post-Bar employment causes increased anxiety, depression, isolation, and related symptoms among students, especially women and underrepresented groups. What is new is the sheer number of law students struggling with serious mental health challenges today—a number that has reached crisis proportions.
This Article is divided into four parts. In Part I, I explore the mental health landscape for high school, college, …
Arkansas Law Review - Volume 78 Issue 3, Journal Editors
Arkansas Law Review - Volume 78 Issue 3, Journal Editors
Arkansas Law Review
No abstract provided.
“We Talked About Straight People Sex”: The Health Education Experiences Of Queer And Trans Youth In Utah, Sonny Partola
“We Talked About Straight People Sex”: The Health Education Experiences Of Queer And Trans Youth In Utah, Sonny Partola
Journal of Multicultural Affairs
This article explores how Utah’s health education curriculum shapes the experiences of queer and trans youth. Drawing on critical ethnography conducted at an urban public high school, the study foregrounds the voices of six queer and trans students. Findings reveal that abstinence-focused and heteronormative curricula render these youth invisible, exclude critical information on queer, trans, and intersex health, and compromise students’ well-being. Participants described feelings of discomfort, irrelevance, and pressure to act as informal educators for peers. Their accounts highlight the urgent need for queerly responsive health education that affirms diverse identities, normalizes inclusion, and provides accurate, relevant information. Such …
“A Bright Spot Of Community”: Finding Joy And Creating Connections In A Landscape Of Crises, Silvia Knighten
“A Bright Spot Of Community”: Finding Joy And Creating Connections In A Landscape Of Crises, Silvia Knighten
Culture, Society, and Praxis
In this dissertation, I examine the Sofa Singers, an online choir formed at the start of the pandemic. Through twice-weekly meetings over Zoom and daily interactions on a private Facebook group, individuals actively work to create their community. Using sensory engagement, technological materials, and monetary fees, participants in the community come to understand their place through affective memories and social relationships. From inside the community, members are able to make sense of the multiple crises they are experiencing; as elderly and retired, my interlocutors struggle to feel included in a space and time built to exclude them. The constancy of …
Exploring The Experiences Of Higher Education Students With Invisible Disabilities, Haley Malinverno
Exploring The Experiences Of Higher Education Students With Invisible Disabilities, Haley Malinverno
Culture, Society, and Praxis
This research analyzes textual data derived from Reddit communities to examine the lived experiences of higher education students and alumni with invisible disabilities (swID). The application of concepts and models of critical disability theory (CDT) are adopted to contextualize student experiences. This study answers two research questions, the first being: R1 - How do reported barriers impact swID in higher education? I find that barriers faced by swID relate to inequities of systemic ableism, with difficulties being a direct side-effect of the inflexible nature of academia. These barriers impact swID in the following ways: The demands of higher education causes …
#Diydiabetes: Type One Diabetes, Stigma, And Control In Digital Networks Of Diy Looping, Sophia M. Shelley
#Diydiabetes: Type One Diabetes, Stigma, And Control In Digital Networks Of Diy Looping, Sophia M. Shelley
Culture, Society, and Praxis
The general public’s awareness of type one diabetes is often lacking and filled with misinformation that can lead to stigma around the disability. Often type one diabetics have to fend for themselves through the means of “DIY diabetes.” The delay in technological innovations and the slow approval rate of Health Canada, compared to the US Food and Drug Administration, makes improving the lives of those with diabetes much more challenging. The self-management of the disability enables diabetics to take agency of their treatment plan and is the primary reason for DIY diabetes. The main reason for this research is to …
Global Prevalence Of Hyperhomocysteinemia Among Adults With Hypertension: A Narrative Review, Wangkheimayum Ashalata Devi Phd Scholar, Dr. Melita Sheilini Associate Professor, Dr. Rinchen Doma Bhutia Assistant Professor, Corresponding Author: Dr.Melita Sheilini, Associate Professor,Department Of Medical-Surgical Nursing, Manipal College Of Nursing, Manipal Academy Of Higher Education, Manipal, Udupi District, Karnataka, India.Contact Number- 8095976561. Email Id: [email protected]
Global Prevalence Of Hyperhomocysteinemia Among Adults With Hypertension: A Narrative Review, Wangkheimayum Ashalata Devi Phd Scholar, Dr. Melita Sheilini Associate Professor, Dr. Rinchen Doma Bhutia Assistant Professor, Corresponding Author: Dr.Melita Sheilini, Associate Professor,Department Of Medical-Surgical Nursing, Manipal College Of Nursing, Manipal Academy Of Higher Education, Manipal, Udupi District, Karnataka, India.Contact Number- 8095976561. Email Id: [email protected]
Manipal Journal of Nursing and Health Sciences
Background: Elevated blood homocysteine (Hcy) levels are a hallmark of hyperhomocysteinemia (HHcy), a metabolic disorder that is known to be a risk factor for cardiovascular illnesses. It greatly raises the risk of vascular problems when combined with hypertension (HTN). However, there are few statistics on the prevalence of HHcy in individuals with HTN. Objective: The present review aims to estimate the global prevalence of HHcy among adults with HTN and to highlight regional disparities, associated risk factors, and implications for clinical practice. Method: The comprehensive literature search was conducted using the PubMed and Google Scholar search engines. Studies published in …
Interventions To Promote Menstrual Health Among Adolescents In Lmic’S: Protocol For A Systematic Review, Precilla Dsilva, Sudhir Prabhu Dr, Prajna Kumari Dr, Baby S. Nayak Dr, Judith Noronha Dr
Interventions To Promote Menstrual Health Among Adolescents In Lmic’S: Protocol For A Systematic Review, Precilla Dsilva, Sudhir Prabhu Dr, Prajna Kumari Dr, Baby S. Nayak Dr, Judith Noronha Dr
Manipal Journal of Nursing and Health Sciences
Background: Menarche brings out significant change in each girl’s life. Coping with the discomforts and adopting the body changes becomes a biggest challenge for every teen. Cost effective non pharmacological interventions will help to bring about improvement in the general wellbeing and quality of life in each adolescents life.
Objective: This review aims to determine the different menstrual interventions adopted by adolescent girls residing in Low and Middle Income Countries (LMIC’s). The Review question will be :What interventions are currently available, and how do they contribute in promoting menstrual health among adolescents from LMICs
Methods: This review will include …
Effectiveness Of Mobile Health Interventions On Cardiovascular Health Among Young Adults – A Systematic Review Protocol, Charlet Jasmine Vaz Mrs, Melita Sheilini Dr, Linu Sara George Dr, Edlin Glane Mathias Dr, Vani Lakshmi R Dr
Effectiveness Of Mobile Health Interventions On Cardiovascular Health Among Young Adults – A Systematic Review Protocol, Charlet Jasmine Vaz Mrs, Melita Sheilini Dr, Linu Sara George Dr, Edlin Glane Mathias Dr, Vani Lakshmi R Dr
Manipal Journal of Nursing and Health Sciences
Abstract
Introduction: Globally, cardiovascular diseases (CVDs) continue to be the primary cause of death and healthcare costs despite significant advancements in treatment effectiveness. The majority of deaths related to CVDs are highly common in countries with middle and low incomes. Objective: To determine the effectiveness of mobile health interventions on cardiovascular health among young adults. Method: A Search will be conducted using PICO format. Primary studies will be searched through electronic databases: Scopus, PubMed (MEDLINE), Web of Science, ProQuest, Embase and CINAHL(Ebsco). The review will only include studies conducted between January 2010 to July 2024 in English. Two authors will …
Yoga And Breathing Techniques For Fear Of Childbirth (Foc) And Quality Of Sleep Among Antenatal Women During Pregnancy – A Systematic Review Protocol, Anjana Sharma, Sonia R B D’Souza Dr., Shripad Hebbar Dr., Govardhan Reddy G Dr.
Yoga And Breathing Techniques For Fear Of Childbirth (Foc) And Quality Of Sleep Among Antenatal Women During Pregnancy – A Systematic Review Protocol, Anjana Sharma, Sonia R B D’Souza Dr., Shripad Hebbar Dr., Govardhan Reddy G Dr.
Manipal Journal of Nursing and Health Sciences
Abstract
Objectives: The objective of this study was to determine the effectiveness of Yoga and breathing techniques in decreasing Fear of Childbirth (FOC) and improving the quality of sleep among antenatal women. Introduction: Pregnancy, labor, and childbirth experiences for women are diverse. One of the issues faced by pregnant women is FOC, which can be stressful for mothers and their families. The global prevalence of FOC among women is 14%, while in India it is 17.7%. Fearful mothers may lack confidence in their ability to give birth, be swayed by unfavorable stories about the process, fear getting hurt during delivery, …
Preliminary Insights From Hospital Records: Disseminated Intravascular Coagulation In Pregnancy And Postpartum In A Tertiary Care Hospital In Karnataka, Mitchelle Shilpa Lewis Ms, Judith Angelitta Noronha Dr
Preliminary Insights From Hospital Records: Disseminated Intravascular Coagulation In Pregnancy And Postpartum In A Tertiary Care Hospital In Karnataka, Mitchelle Shilpa Lewis Ms, Judith Angelitta Noronha Dr
Manipal Journal of Nursing and Health Sciences
Introduction- During pregnancy and labor, women undergo changes in their bodies, and are at risk for various complications during this period of life. Disseminated intravascular coagulation (DIC)during pregnancy is a debilitating, life-threatening condition that impacts the health of women.
Purpose- This study aimed to identify the incidence ,factors predisposing women to DIC and the treatment modalities used for women during pregnancy and postpartum to manage DIC
Materials and Methods- A retrospective cohort study was conducted to identify incidence, symptoms, laboratory findings, treatment, and maternal outcomes for the last five years. Records of the patients diagnosed with DIC during pregnancy and …
A Descriptive Study To Assess The Life Skills Among Adolescents In Tea Garden Of Assam., Catherine Kujur, Sandeep Kollipara, Chitra Bora
A Descriptive Study To Assess The Life Skills Among Adolescents In Tea Garden Of Assam., Catherine Kujur, Sandeep Kollipara, Chitra Bora
Manipal Journal of Nursing and Health Sciences
Abilities that facilitate human to adjust with the numerous challenges of life are life skills . Adolescent is a stage of transition, where changes occur physically and psychologically and adolescents need to change and adapt towards these transitions in order to deal effectively in life. The current study focused to assess the life skills of tea garden teenagers. Descriptive research design with quantitative research approach was selected . The adolescents aged between 14 years to 17 years who had studied upto class VI were included in the study through total enumeration method with sample size 300. Socio-demographic datasheet (10 items) …
Effect Of Planned Teaching On The Necklace Method Of Natural Family Planning Among Female Students In Moodbidri, Manisha S. Poojary, Prof. Jenviv Kavitha D,Silva
Effect Of Planned Teaching On The Necklace Method Of Natural Family Planning Among Female Students In Moodbidri, Manisha S. Poojary, Prof. Jenviv Kavitha D,Silva
Manipal Journal of Nursing and Health Sciences
Introduction: The necklace method is a contemporary natural family planning approach that empowers women by enhancing accessibility, addressing knowledge deficiencies, and assisting couples in effectively planning and spacing their pregnancies. Objectives: This study aimed to evaluate the effectiveness of a structured teaching program on the knowledge of the necklace method as a natural family planning method among female students. Methods: A quantitative research design with a quasi-experimental approach, utilising a one-group pre- and post-test format, was employed. The study involved 60 female students from selected degree colleges in Moodbidri. Participants were chosen using a probability stratified random sampling technique. Data …
Impact Of The Covid-19 Outbreak On The Emotional Responses And Self-Protective Behaviors Of Nursing Students., Banisha Lyngdoh Nonglait, Jyothsna Jennifer Hans, S P Sagar, Gayatri Poojari, Sanju Pant, Maria Pais Dr
Impact Of The Covid-19 Outbreak On The Emotional Responses And Self-Protective Behaviors Of Nursing Students., Banisha Lyngdoh Nonglait, Jyothsna Jennifer Hans, S P Sagar, Gayatri Poojari, Sanju Pant, Maria Pais Dr
Manipal Journal of Nursing and Health Sciences
Background: The COVID-19 pandemic has disrupted nearly every aspect of our society. The higher education sector is no exception. Students face an increasingly unstable environment, impacting their physical and emotional health.
Objectives: The study aims to determine students' emotional responses to the impacts of the COVID-19 outbreak. It also assesses their behavior in protecting themselves from cross-contamination during this period.
Methods: A descriptive survey design was used in this study, which included 61 undergraduate students. To collect data, researchers employed socio-demographic questionnaires alongside a structured attitude survey designed to assess emotional responses and self-protective behaviors related to COVID-19. The reliability …
Evaluating The Impact Of Targeted Training On The Attitude And Knowledge Of Evangelical Pastors On Hiv In Tamil Nadu: A Pre-Test Post-Test Study, Ruth Duraiswamy Mrs
Evaluating The Impact Of Targeted Training On The Attitude And Knowledge Of Evangelical Pastors On Hiv In Tamil Nadu: A Pre-Test Post-Test Study, Ruth Duraiswamy Mrs
Manipal Journal of Nursing and Health Sciences
Abstract
Introduction: HIV/AIDS continues to be a significant global health challenge, with persistent stigma and misinformation hindering effective management, particularly within faith-based communities. Hence a study aimed to evaluate the impact of targeted training on the attitudes and knowledge of evangelical pastors in Tamil Nadu, India, regarding HIV was organized so that the pastors who are faith leaders in the Christian community can work towards removing stigma and ill treatment of HIV patients in the society. Objective: the objectives of the study were to assess the baseline knowledge and attitudes of evangelical pastors in Tamil Nadu regarding HIV, providing …
A Cautionary Tale: Increasing Research In Ophthalmology Residency Applications, Stephanie C. Nguyen, Eric L. Wan, Reena A. Garg, Jay M. Lustbader
A Cautionary Tale: Increasing Research In Ophthalmology Residency Applications, Stephanie C. Nguyen, Eric L. Wan, Reena A. Garg, Jay M. Lustbader
Journal of Academic Ophthalmology
The increasing emphasis on research productivity in ophthalmology residency applications reflects broader shifts in medical education and raises important questions about equity, authenticity, and holistic evaluation. As grading systems and standardized examinations move toward pass/fail formats, research has become one a principal way for applicants to distinguish themselves from other applicants. While this shift has increased scholarly output, it has also exacerbated disparities in access to mentoring, encouraged superficial research engagement, and may undermine diversity within the field. Evidence consistently shows that diversity among physicians improves patient outcomes and promotes equitable care, underscoring the need for the residency selection process …
Assessing United States Ophthalmology Departments By Faculty Academic Achievement, Jovany J. Franco, Austin T. Gregg, Jeremy N. Shapiro, Ashley K. Roth, Eric T. Strand, Dhruva Gupta, Ariane D. Kaplan
Assessing United States Ophthalmology Departments By Faculty Academic Achievement, Jovany J. Franco, Austin T. Gregg, Jeremy N. Shapiro, Ashley K. Roth, Eric T. Strand, Dhruva Gupta, Ariane D. Kaplan
Journal of Academic Ophthalmology
Background: Reputation-based rankings of U.S. ophthalmology departments strongly influence trainee and faculty decision-making but rely heavily on subjective survey data. Objective, transparent methodologies for comparing academic achievement across departments are lacking.
Purpose: To assess U.S. ophthalmology departments using a novel, objective, standardized, and transparent system employing three measures of faculty academic achievement: National Institutes of Health (NIH) funding, lifetime Hirsch (h)-index, and journal impact factor (JIF)-weighted journal editorial board membership.
Methods: In this cross-sectional study, a list of ophthalmology residency-trained faculty was compiled for each U.S. ophthalmology department with an associated residency training program. Faculty member NIH …
Impact Of Video-Guided Indirect Ophthalmoscopy On Medical Student Confidence And Ability, Kyle Vinson, Eleanor Burton, Abdullah Abou-Samra, Caroline Kim, Amen Nigussie, Roshni Dholkawala, Michael Cusick, Gabrielle Turski, Arjun Dirghangi, Arthi Venkat
Impact Of Video-Guided Indirect Ophthalmoscopy On Medical Student Confidence And Ability, Kyle Vinson, Eleanor Burton, Abdullah Abou-Samra, Caroline Kim, Amen Nigussie, Roshni Dholkawala, Michael Cusick, Gabrielle Turski, Arjun Dirghangi, Arthi Venkat
Journal of Academic Ophthalmology
Background: Binocular indirect ophthalmoscopy (BIO) is a challenging skill to learn and teach.
Purpose: To evaluate the utility of video-guided BIO for training medical students without prior BIO experience using Scanoptix, a novel, wireless, ophthalmoscope-mounted camera.
Methods: This was a mixed-methods study including a survey and prospective, double-armed intervention. Medical students at the University of Virginia School of Medicine without prior BIO experience were recruited via email and randomized into video-guided and non-video-guided indirect ophthalmoscopy training groups (VIO and nVIO, resp.). Both groups underwent a demonstration session led by a retina specialist followed by an instructional session …
Morbidity And Mortality Conference In Ophthalmology: Pilot Study On Maximizing Quality While Optimizing Education, Shwetha Mudalegundi, Andrew Melson, Alice Yang Zhang, Daniel Tu, Jamie Rosenberg, Daniel Moore, Daniel Knoch, Jessica M. Kang, Fasika Woreta, Laura Green, Ramya Swamy, Anjali Tannan, Saras ` Ramanathan
Morbidity And Mortality Conference In Ophthalmology: Pilot Study On Maximizing Quality While Optimizing Education, Shwetha Mudalegundi, Andrew Melson, Alice Yang Zhang, Daniel Tu, Jamie Rosenberg, Daniel Moore, Daniel Knoch, Jessica M. Kang, Fasika Woreta, Laura Green, Ramya Swamy, Anjali Tannan, Saras ` Ramanathan
Journal of Academic Ophthalmology
Background: Discussion of medical and surgical adverse events between peers and learners allows for all members of a learning community to benefit from lessons learned while assessing and resolving the events. The methods by which adverse events are discussed in academic ophthalmology departments and how those discussions impact attending and resident education have received little attention in the published literature.
Purpose: To report the results of our survey of U.S. academic ophthalmology residency programs using a mixed methods analysis to determine the current frequency, structure, purpose, and outcomes of morbidity and mortality (M&M) or other quality improvement conferences. …
Unravelling The Dual Role Of Naringenin In Response To Cytotoxicity Caused By Indomethacin And Diclofenac, Kaitsuda Saiprom, Cherdsak Boonyong, Suree Jianmongkol
Unravelling The Dual Role Of Naringenin In Response To Cytotoxicity Caused By Indomethacin And Diclofenac, Kaitsuda Saiprom, Cherdsak Boonyong, Suree Jianmongkol
The Thai Journal of Pharmaceutical Sciences
Background: Indomethacin and diclofenac exhibited similar cytotoxic mechanisms, involving the generation of cell stress, disruption of mitochondria, and lysosome functions. Recently, we reported that naringenin, a natural bioactive flavonoid, elicited cytoprotection against indomethacin but not diclofenac in Caco-2 cells.
Objectives: This study investigated whether these divergent effects were associated with lysosomal integrity and autophagy.
Methods: Caco-2 cells were treated with naringenin (100 μM; non-cytotoxic concentration) for 24 h, followed by either indomethacin or diclofenac (1000 μM). After 72-h treatment, cell viability, apoptosis and lysosomal integrity were measured by methylthialazole tetrazolium, neutral red uptake, annexin V/propidium iodide staining, …
Perceptions And Expectations Of Healthcare Professionals About The Roles Of Pharmacists At A Tertiary Care Hospital, Pimpiorn Punturat, Kornkaew Chanthapasa
Perceptions And Expectations Of Healthcare Professionals About The Roles Of Pharmacists At A Tertiary Care Hospital, Pimpiorn Punturat, Kornkaew Chanthapasa
The Thai Journal of Pharmaceutical Sciences
Background: Pharmacy education in Thailand has shifted toward a patient-centered approach through the implementation of the 6-year Doctor of Pharmacy (Pharm D.) program. Despite this transition, pharmaceutical care services remain limited due to challenges such as inadequate clinical skills, communication barriers, and differing perceptions among healthcare professionals. The perceptions and expectations of healthcare professionals about pharmaceutical care have not been fully examined in a tertiary hospital in Thailand. Objective: The objective of the study was to examine and compare the perceptions and expectations of pharmacists’ role in pharmaceutical care among physicians, nurses, and pharmacists at a tertiary care …
Pharmacovigilance Practices For New Drugs In Thailand: A Situation Analysis In Tertiary And University Hospitals, Nisittra Polkot, Osot Nerapusee, Pantira Parinyarux, Puree Anantachoti
Pharmacovigilance Practices For New Drugs In Thailand: A Situation Analysis In Tertiary And University Hospitals, Nisittra Polkot, Osot Nerapusee, Pantira Parinyarux, Puree Anantachoti
The Thai Journal of Pharmaceutical Sciences
Background: In 2017, Thailand’s Food and Drug Administration introduced a risk-based safety monitoring program (SMP) aimed at strengthening pharmacovigilance (PV) for new drugs, including new chemical entities and biologics. Despite this policy shift, drug safety monitoring continues to rely primarily on spontaneous adverse drug reaction (ADR) reporting. This study aimed to explore the implementation of PV practices for drugs with SMP status in selected tertiary and university hospitals in Thailand.
Materials and Methods: A qualitative study was conducted using in-depth interviews. Pharmacists and physicians involved in drug safety monitoring were invited. Eight hospitals (five university and three tertiary …
Exploring Phytoconstituents For Parkinson’S Disease: Insights From Network Pharmacology, Molecular Modeling And In Vivo Investigations, Shiva Priya, Divakar Selvaraj, Rashi Jain, Kavyashree G. S., Soumya V., Venkatesh Gunasekaran, Ramu G., Saravanan Jayaram
Exploring Phytoconstituents For Parkinson’S Disease: Insights From Network Pharmacology, Molecular Modeling And In Vivo Investigations, Shiva Priya, Divakar Selvaraj, Rashi Jain, Kavyashree G. S., Soumya V., Venkatesh Gunasekaran, Ramu G., Saravanan Jayaram
The Thai Journal of Pharmaceutical Sciences
Background: The network pharmacology approach is used to identify novel therapeutic agents that target multiple disease targets through analysis of complex disease networks by integrating systems biology and computational approaches. Objectives: The present study aims to identify the principal targets implicated in the pathogenesis of Parkinson’s disease (PD) and major phytoconstituents that could potentially modulate the major targets to achieve therapeutic benefits in PD through a network pharmacology-based approach. Materials and Methods: The DisGeNET database was used to select the major targets involved in the pathogenesis of PD. The most important targets among the selected proteins were …
Isolation And Antibacterial Evaluation Of Bioactive Compounds From Mussaenda Philippica A.Rich.: A Bioassay-Guided Approach, M. Rifqi Efendi, Mesa Sukmadani Rusdi, Muhammad Iqbal, Ilham Padavi, Sri Indah Pirmawati, Deddi Prima Putra
Isolation And Antibacterial Evaluation Of Bioactive Compounds From Mussaenda Philippica A.Rich.: A Bioassay-Guided Approach, M. Rifqi Efendi, Mesa Sukmadani Rusdi, Muhammad Iqbal, Ilham Padavi, Sri Indah Pirmawati, Deddi Prima Putra
The Thai Journal of Pharmaceutical Sciences
Background: Mussaenda philippica A.Rich. (commonly known as Nusa Indah in Indonesia), a member of the Rubiaceae family, has been traditionally used throughout Southern Asia to treat various ailments, including bacterial infections, inflammation, ulcers, and liver disorders. These medicinal uses are particularly associated with its bark, leaves, sepals, and root. Objectives: This study aimed to isolate and identify bioactive compounds from M. philippica white modified sepals using a bioassay-guided approach and evaluate their antibacterial activity.
Materials and Methods: The study consisted of four main stages: (i) methanol extraction and liquid–liquid partitioning of M. philippica sepals; …
Optimizing Solvent Composition For Enhanced Extraction Of Phenolic Content And Antioxidant Activity From Coleus Scutellarioides Through I-Optimal Mixture Design, Sinta Mutiara Dwi Lestari, Utami Dyah Syafitri, Waras Nurcholis
Optimizing Solvent Composition For Enhanced Extraction Of Phenolic Content And Antioxidant Activity From Coleus Scutellarioides Through I-Optimal Mixture Design, Sinta Mutiara Dwi Lestari, Utami Dyah Syafitri, Waras Nurcholis
The Thai Journal of Pharmaceutical Sciences
Background: Reactive oxygen species are unstable molecules that contribute to oxidative stress and are associated with numerous degenerative diseases. The leaves of Coleus scutellarioides are rich in phenolic and flavonoid compounds, which possess strong antioxidant properties.
Objectives: This study aimed to optimize the composition of water, ethanol, and methanol as solvents using the I-optimal mixture design to enhance the extraction of total phenolic content (TPC), 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, and ferric reducing antioxidant power (FRAP).
Methods: Each extraction was performed by macerating 1 g of powdered C. scutellarioides leaves in 20 mL of the designated …
Hot-Melt Extrusion-Based Solid Dispersion Of Aripiprazole: Preparation, Characterization, And In Vitro Evaluation, Nensi Raytthatha, Jigar Ramanlal Vyas
Hot-Melt Extrusion-Based Solid Dispersion Of Aripiprazole: Preparation, Characterization, And In Vitro Evaluation, Nensi Raytthatha, Jigar Ramanlal Vyas
The Thai Journal of Pharmaceutical Sciences
Background: Aripiprazole (ARI), a biopharmaceutics classification system (BCS) class IV drug, exhibits poor water solubility and low permeability, resulting in limited bioavailability. Addressing these challenges requires innovative approaches to enhance solubility. This study focuses on the development and evaluation of solid dispersions (SDs) of ARI using “hot-melt extrusion,” (HME) a scalable and solvent-free method known for its ability to create stable amorphous structures. Soluplus® (SP) and Kollidon® 30 were employed as hydrophilic polymeric carriers to improve the solubility and stability of the amorphous drug form. Results: SDs were prepared by taking drugs and carriers (SP and Kollidon …
(((Qpie))) Prior Art Declaration 4 Of 9 From Particles To Resonance Science, Teddy Burroughs
(((Qpie))) Prior Art Declaration 4 Of 9 From Particles To Resonance Science, Teddy Burroughs
Defensive Publications Series
The Grand Unified Theory (QPIE)
Perspective Is Everything – What we are Believing, Expecting and Feeling in Life Matters
(((QPIE))) Prior Art Declaration 4 of 9 From Particles to Resonance Science
From Particles to Resonance: A Formal White Paper on QPIE, NSRF, and the Recovery of a Suppressed Scientific Paradigm
Part I
The Long Suppression of the Substrate: From Aether to Particles
Abstract
For more than three centuries, Western science has been dominated by a particle-centric, binary, and reductionist worldview. This paradigm—while extraordinarily successful at engineering and mechanization—has systematically excluded relational meaning, coherence, and nonlocal structure from its formal models. …