Digital Commons Network^™

Adapter Changes Of Central Line Patients On Total Parenteral Nutrition, Courtney Erin Schappell

Walden Dissertations and Doctoral Studies

Central line-associated bloodstream infections (CLABSIs) remain a significant and preventable patient safety issue, especially among hospitalized patients receiving total parenteral nutrition (TPN). Patients on TPN face a higher risk of infection due to the high glucose content of the solution and the frequent access required for central line therapy. The Centers for Disease Control and Prevention and the Agency for Healthcare Research and Quality have recognized CLABSI prevention as a national priority. In addition, there is emphasis on high-risk groups like patients receiving TPN. The Infusion Therapy Standards of Practice, an evidence-based guideline, recommends catheter care, including timely adapter (i.e., …

A Phase-Ii Randomized Controlled Pilot And Feasibility Study Of Nicotinamide Riboside Supplementation In Older Adults With Amnestic Mild Cognitive Impairment, Christopher R. Martens, Kevin P. Decker, Theodore M. Deconne, Faria Sanjana, Fiona Horvat, Nicholas A. Rizzi, Catherine Awad, Elizabeth Habash, Joshua C. Hobson, Michael L. Armstrong, Nichole Reisdorph, Ryan T. Pohlig, Alyssa M. Lanzi, Curtis L. Johnson, Matthew L. Cohen, James M. Ellison

Department of Psychiatry and Human Behavior Faculty Papers

Abstract

Background

The decline of nicotinamide adenine dinucleotide (NAD+) with aging may elevate risk of Alzheimer’s disease and related neurocognitive disorders (ADRD) by impairing cellular energy metabolism and reducing cerebral blood flow.

Method

We conducted a 12-week double-blind, randomized, placebo-controlled pilot study to evaluate the safety, tolerability, and preliminary efficacy of the NAD+ precursor, nicotinamide riboside (NR; 500 mg b.i.d.), for enhancing cognitive function and cerebral perfusion in older adults with mild cognitive impairment (MCI).

Result

52 participants (33 females, 19 males) were randomized and 42 completed the trial (NR = 22, placebo = 20). Adherence was similar between groups …

Nurse Practitioner-Led Mobile Clinics: A Lifeline For Underserved Communities, Michelle Hepburn

DNP Qualifying Manuscripts

Traditional brick-and-mortar clinics have failed underserved populations, especially those who are unhoused, living with serious mental illness or experiencing substance use disorders. Nurse practitioner (NP)-led mobile health clinics (MHC) offer an exceptional opportunity to impact healthcare for underserved populations. This model addresses the constructs of social determinants of health replacing episodic care with longitudinal outreach. It offers an equitable and scalable model that is transformative; reducing disparities, and promoting sustainable health outcomes for underserved populations, and it creates a pathway that reduces avoidable emergency department visits and advances health equity.

State Of California Cannabis Reporting, University Of Mississippi – National Center For Cannabis Research And Education

California

No abstract provided.

The Nonlinguistic Factors That Predict Spanish Oral Proficiency, Merrie Kay Ames

Theses and Dissertations

This study investigates the predictive power of self-assessment and nonlinguistic factors in determining Spanish oral proficiency among university learners. Drawing on data from 2,475 undergraduate students enrolled in a third-year Spanish course at Brigham Young University, the research examines how self-assessed speaking ability and experiential background variables--including age of acquisition, mission service, dual immersion, and study abroad--influence Oral Proficiency Interview - Computer (OPIc) scores. A one-way ANOVA revealed a statistically significant but modest relationship between students' calibration (self-assessment minus actual ability) and their OPIc ratings, suggesting that learners can generally approximate their speaking proficiency within two sublevels. A multiple regression …

Integration Of Afghan Refugee Professionals Into American Society, Khatera Bahrami

Walden Dissertations and Doctoral Studies

This study explored the social and psychological challenges Afghan refugee professionals experienced when they entered the U.S. workforce after being forcibly displaced. Trauma, job loss, and cultural adjustment significantly impacted their mental health and reintegration. The study examined how social and psychological obstacles impacted their cultural adjustment, well-being, and capacity to deal with credentialing and professional demands. This research employed a qualitative phenomenological design, grounded in Conservation of Resources (COR) Theory and the Stress Appraisal Model, using 60-minute audio-only, semi-structured interviews with 10 Afghan refugee professionals. Using Reflexive Thematic Analysis (RTA), according to the findings, participants faced challenges relating to …

Chaminade Julienne Senior Named 2026 W.S. Mcintosh Scholar, University Of Dayton

News Releases

Johanna Matota, a senior at Chaminade Julienne Catholic High School, earned the W.S. McIntosh Memorial Leadership Award.

Machine Learning–Based Prediction Of Potentially Inappropriate Prescribing In Geriatric Patients Presenting To The Emergency Department At Al-Qatif Central Hospital, Saudi Arabia, Aymen Alqurain

Saudi Toxicology Journal

Potentially inappropriate prescribing (PIP) is an avoidable factor leading to adverse drug events in older adults, particularly in the emergency department (ED). This study aimed to train and validate a machine learning (ML) model to predict the probability of PIP in elderly patients in the ED. This retrospective analysis encompassed patients aged 65 years and above who presented to the Al-Qatif Central Hospital. PIPs were identified using a validated screening tool designed for older persons to ensure appropriate treatment. Variables have been detected by least absolute shrinkage and selection operator regression. An extreme gradient boosting model was trained and assessed …

Investigating Trust Between Hispanic Immigrants And Law Enforcement, Nina Marie Morales-Perez

Walden Dissertations and Doctoral Studies

In this qualitative study, the evolving perceptions of law enforcement among child immigrants from Central and South America following their immigration to the United States were investigated. Anchored in social learning theory, the aim was to discern whether interactions with law enforcement in their home countries and the United States influence these perceptions. A phenomenological approach was used to conduct in-depth interviews with six Latino individuals who immigrated between the ages of 7 and 17 and are at least 18 years old at the time of their interview. Participants were recruited through purposeful sampling, and interview questions were used to …

Unintended Consequences Of California’S Proposition 12 Affecting Low-Income Communities, Blanca Estella Garcia

Walden Dissertations and Doctoral Studies

The background of this study established context describing the 2018 implementation of Proposition 12 in California, a law intended to improve animal welfare standards. The central problem identified the law’s unintended effects on multiple stakeholders, which prior literature suggested could include increased production costs and limit consumer access. However, existing studies have focused on theoretical and economic projections, leaving gaps in understanding secondary data research and practical impacts on farmers and low-income consumers. The purpose of the study was to examine unforeseen consequences of Proposition 12, with attention to its direct and indirect impacts on animal welfare, farmers, and low-income …

The Mitochondria Is The Source Of Hepatic Amyloid Precursor Protein And Peripheral Amyloid Beta: Implications Of Alcohol-Induced Liver Steatosis In Alzheimer's Disease, Josephine Chu, Ross A. Steinberg, Brian Carson, Devaraj Venkatapura Chandrashekar, Rachita K. Sumbria, Derick Han

Pharmacy Faculty Articles and Research

Background

Alcohol-induced liver injury occurs in the pericentral region of the liver and can induce mitochondrial remodeling and exacerbate Alzheimer's Disease (AD) progression. Subpopulations of mitochondria: general mitochondria (GM), peridroplet mitochondria (PDM) and endoplasmic reticulum(ER)-bound mitochondria (ERM) maintain cellular homeostasis via energy synthesis, lipid homeostasis, and regulation of intracellular calcium. Hepatic amyloid precursor protein (APP) is a source of peripheral amyloid beta (aB) and affects AD pathology in the brain. Understanding the localization and expression of hepatic APP in mitochondrial subpopulations are critical to understanding aB metabolism and may play a role in identifying a potential mechanism for metabolic dysfunction. …

Implementing Sbar-Based Staff Education And A Diabetes-Specific Discharge Checklist To Reduce Patient Identification Errors During Handoffs, Maragarate Nesoa

Walden Dissertations and Doctoral Studies

This doctoral project was an organization change initiative using staff education to reduce patient identification errors during handoffs among older adults with Type 2 Diabetes (T2DM). Misidentification during transitions of care contributes to medication errors, unnecessary readmissions, and preventable adverse events

Research And Innovation Update, December 23, 2025, Office Of The Vice President For Research And Innovation

Office of Research, Economic Engagement and Outreach

No abstract provided.

Investigating The Relationship Between Breast Cancer Risk Factors And An Ai-Generated Mammographic Texture Feature In The Nurses' Health Study Ii, Xueyao Wu, Shu Jiang, Aaron Ge, Constance Turman, Graham Colditz, Rulla M Tamimi, Peter Kraft

2020-Current year OA Pubs

The mammogram risk score (MRS), an AI-driven mammographic texture feature, strongly predicts breast cancer risk independently of breast density, though underlying mechanisms remain unclear. Using data from the Nurses' Health Study II (292 cases, 561 controls), we validated MRS's association with breast cancer and evaluated its relationships with established breast cancer risk factors through observational analyses, polygenic score analyses, and Mendelian randomization. MRS was significantly associated with breast cancer risk before (OR=1.92 per SD increase; 95% CI:1.57 to 2.35; 10-year AUC=0.69) and after adjustment for predicted BI-RADS density (OR=1.85; 95% CI:1.49 to 2.30). Early life body size and adult body …

Association Of Shock Index And Variants With Mortality In Acute Pulmonary Embolism, Cameron P Upchurch, Kristen Sanfilippo, Daphne Lew, Maanasi Samant, Rachel Mcdonald

2020-Current year OA Pubs

INTRODUCTION: Pulmonary embolism (PE) is common with potential for morbidity and mortality. Several PE risk-stratification tools exist; however, more granular and patient-specific indicators of potential decompensation or short-term mortality that can be easily obtained are needed for the bedside clinician to further sub-stratify risk and inform management decisions. We sought to determine the association of early emergency department (ED) measurement of the shock index (SI) and SI variants (modified SI, SI to peripheral oxygen saturation ratio, age-adjusted SI, respiratory-adjusted SI, and double product) and mortality among patients with acute PE.

METHODS: This was an observational case-control study of adult patients …

Soluble Urokinase Plasminogen Activator Receptor And Acute Kidney Injury In Hematopoietic Cell Transplantation, Bhavna Bhasin-Chhabra, Tao Wang, John E Levine, Shalini Shenoy, Miguel-Angel Perales, Asad Bashey, Hershel Raff, Wael Saber

2020-Current year OA Pubs

Acute kidney injury (AKI) frequently follows hematopoietic cell transplantation (HCT). Soluble urokinase-type plasminogen activator receptor (suPAR) is a biomarker of AKI in the general population. We evaluated suPAR and its association with AKI requiring dialysis (AKI-D) in patients undergoing allogeneic HCT (alloHCT). Performance of suPAR was compared with serum creatinine (sCr) and neutrophil gelatinase-associated lipocalin (NGAL). Data were obtained from the Blood and Marrow Transplant Clinical Trials Network 1202 cohort, an observational study of 1709 alloHCT recipients. Adults aged ≥18 years with AKI-D after HCT were included. Adults who did not develop AKI were included as controls and matched 1:1. …

Predictive Modeling Of Hematoma Expansion From Non-Contrast Computed Tomography In Spontaneous Intracerebral Hemorrhage Patients, Natasha Ironside, Shinjini Kundu, Et Al.

2020-Current year OA Pubs

Hematoma expansion is a consistent predictor of poor neurological outcome and mortality after spontaneous intracerebral hemorrhage (ICH). An incomplete understanding of its biophysiology has limited early preventative intervention. Transport-based morphometry (TBM) is a mathematical modeling technique that uses a physically meaningful metric to quantify and visualize discriminating image features that are not readily perceptible to the human eye. We hypothesized that TBM could discover relationships between hematoma morphology on initial Non-Contrast Computed Tomography (NCCT) and hematoma expansion. 170 spontaneous ICH patients enrolled in the multi-center international Virtual International Trials of Stroke Archive (VISTA-ICH) with time-series NCCT data were used for …

Light-Induced Oslike1 Phosphorylation Enhances Rice Resistance Against Blast Disease, Jiangtao Liu, Lei Su, Wenya Wang, Jintao Wang, Weizhong Chen, Zhixiang Yang, Leiyun Yang, Gang Li, Xinyu Liu, Haifeng Zhang, Zhongqiang Qi, Yongfeng Liu, Yuqiang Liu, Ping Wang, Muxing Liu, Zhengguang Zhang

School of Graduate Studies Faculty Publications

Rice blast caused by Magnaporthe oryzae poses a major threat to world food supply. Conditions conducive to the disease include insufficient light. Our previous studies found that light-dependent phosphorylation of light-harvesting complex II protein (LHCB5) mediates rice immunity; however, the underlying mechanisms, in particular, the upstream regulators of LHCB5 phosphorylation, remain unknown. Here, we show that OsLIKE1 functions as a lectin receptor-like kinase (LecRLK) to play a critical role in rice resistance against M. oryzae. OsLIKE1 interacts with and phosphorylates LHCB5. In addition, we find two phosphorylation sites in the kinase domain of OsLIKE1 important for its auto-phosphorylation and phosphorylation …

Characterization Of Aluminum Black Dross Leachate From The Tertiary Smelting Industry In Jombang, East Java, Maya Lukita, Etty Riani, Ahyar Ismail, Zaenal Abidin

Makara Journal of Science

Aluminum black dross is a type of hazardous waste because it readily reacts with water to produce gas. Previous studies have reported the potential dangers of aluminum black dross to humans and the environment. This study examined the characteristics of aluminum black dross from Jombang Regency, East Java Province. The properties investigated included the volume of gas produced during leaching, the solubility of salts and aluminum under various conditions, and the mineral characteristics analyzed via Fourier transform infrared (FTIR) spectroscopy, X-ray fluorescence (XRF), and X-ray diffraction (XRD). Notably, 115 mL of gas was produced from each 0.5 g of aluminum …

Synergistic Effects Of Gfap With Tnfr1 And Tnfr2 On Conversion To Ad Dementia And Overall Survival Across The Alzheimer’S Disease Spectrum, Laura Alejandra Ramirez Tirado, Ann D. Cohen, C. Elizabeth Shaaban, Cristy Matan, Brian J. Lopresti, Milos D. Ikonomovic, Thomas K. Karikari, Victor L. Villemagne, Oscar L. Lopez

Department of Neurology Faculty Papers

Background: We recently reported synergistic effects of TNFR1 and TNFR2 with
astrogliosis resulting in greater vascular burden and neurodegeneration, particularly in
Aβ+ participants. Here, we aimed to assess the interactions of peripheral inflammation
and astrogliosis on incidence of AD dementia and mortality. We hypothesized
synergistic effects with astrogliosis resulting in increased incidence of dementia, and
mortality, particularly in Aβ+ participants.
Methods: Participants of the Gingko evaluation of memory (GEM) study underwent
PiB-PET scans between 2009-2018. GFAP and peripheral inflammatory markers were
measured in 2009 by immunoassay. We evaluated the relationship of peripheral
markers of inflammation (TNFR1,TNFR2) and astrogliosis (GFAPdementia incidence …

The Role Of Reproductive Aging And Surgeries For Alzheimer’S Disease And Related Dementias (Adrd) Diagnoses In The Cardiovascular Health Study, Alexis Reeves, Oscar L. Lopez, Michelle D. Shardell, Hoda S. Abdel Magid, C. Elizabeth Shaaban, Michelle C. Odden

Department of Neurology Faculty Papers

Abstract

Background

Most US individuals with ADRD are women. Menopause typically occurs in midlife, accompanied by declines in potentially neuroprotective and cardioprotective hormones. Earlier menopause leads to earlier exposure to decreased sex hormones, potentially increasing ADRD risk. Surgical menopause via reproductive surgeries may cause a sudden loss of hormones and may represent be a modifiable risk factor for ADRD. We aimed to determine if menopausal type and age are associated with physician adjudicated-ADRD diagnoses.

Methods

Data were from 3371 women prospectively followed from age 65+ years. Participants self-reported age of menopause and/or surgeries, hormone-therapy, education, and race (Black/White). For this …

Seth Matlick, Seth Matlick, Erin Elder

Oral Histories of Farming along the Middle Rio Grande

No abstract provided.

Correlational Study Of Health Checkups And Patient Wellness: Epidemiological Evaluation On Prophylaxis Pathways, Samantha H. Beaubrun

Walden Dissertations and Doctoral Studies

Health checkups and wellness visits are a vital pathway to early detection and diagnosis of disease. It is not known whether young adults, insured or not, are opting into preventive care services to optimize health status via health checkups/wellness visits at primary care academic health centers. The purpose of this quantitative study was to examine the relation of wellness visits to healthcare insurance and health status while adjusting for gender among young adults ages 18–35 years in the United States. A descriptive correlational design was used with the 2023 National Health Interview Survey data set (N = 6,544). The results …

Draft Final Quarterly Operations And Maintenance Report: Butte Treatment Lagoon System – Third Quarter 2025, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

957 Park Avenue Llc V. Ordonez

All Decisions

The Appellate Term, First Department, affirmed a Civil Court final judgment awarding possession to the landlord in a holdover summary proceeding. The tenant, claiming succession rights as a non-traditional family member to a deceased rent-controlled tenant, failed to establish the requisite emotional and financial commitment and interdependence. The courts found the relationship was "one-sided," lacking mutual support as required by NY City Rent & Eviction Regs § 2204.6[d]. The decision highlights the high burden on a tenant seeking non-traditional family member succession, noting the trial court's warranted conclusion based on the asymmetric dynamic of the relationship.

Simultaneous Initiation Of Finerenone And Empagliflozin Across The Spectrum Of Kidney Risk In The Confidence Trial, Muthiah Vaduganathan, Jennifer B Green, Hiddo J L Heerspink, Sung Gyun Kim, Johannes F E Mann, Janet B Mcgill, Amy Mottl, Masaomi Nangaku, Julio Rosenstock, Peter Rossing, Li Li, Na Li, Katja Rohwedder, Charlie Scott, Rajiv Agarwal

2020-Current year OA Pubs

BACKGROUND: The CONFIDENCE (COmbinatioN effect of FInerenone anD EmpaglifloziN in participants with CKD and type 2 diabetes using a UACR Endpoint) trial investigated the safety and efficacy of simultaneously initiating finerenone and empagliflozin for patients with chronic kidney disease (CKD) and type 2 diabetes. This prespecified analysis aimed to determine if the predicted risk of kidney disease progression, based on KDIGO risk categories, influenced the benefits and safety of this combination therapy.

METHODS: The double-blind, double-dummy trial randomized 818 adults with CKD and type 2 diabetes [urine albumin-creatinine ratio (UACR) ≥100 to < 5000 mg/g] to receive once-daily finerenone plus empagliflozin, finerenone alone or empagliflozin alone, all in addition to a renin-angiotensin system inhibitor. The relative change in UACR from baseline to day 180 (primary endpoint) and a >30% reduction in UACR (secondary endpoint) across KDIGO …

Ribosomal Protein Control Of Hematopoietic Stem Cell Transformation Through Regulation Of Metabolism, Bryan Harris, Stephen Sykes, Et Al.

2020-Current year OA Pubs

We report here that expression of the ribosomal protein RPL22 is frequently reduced in human myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML), and reduced RPL22 expression is associated with worse outcomes. Mice null for Rpl22 display characteristics of an MDS-like syndrome and develop leukemia at an accelerated rate. Rpl22-deficient mice also display enhanced hematopoietic stem cell (HSC) self-renewal and obstructed differentiation potential, which arises not from reduced protein synthesis but from altered metabolism, including increased fatty acid oxidation (FAO) and a striking induction of the stemness factor Lin28b in the resulting leukemia. Lin28b promotes a substantial increase in lipid …

Hospital Healthcare Worker Clothes Uses Compared To The Infection Control Guidelines, Peshraw Yassin Sharif, Ramand Mohammed Haji

Hilla University College Journal For Medical Science

Background: Hospital clothing can inadvertently be a vector for harmful microbes, spreading pathogens through direct contact or airborne particles when clothes are touched or disturbed. Contaminated linens and clothing not only place patients at risk but also threaten the safety of healthcare workers. The current study compares the daily use of healthcare workers’ hospital clothes according to the infection prevention and control guidelines.

Method: A descriptive cross-sectional study was conducted on 450 healthcare staff providing medical care to patients in Raparin province, Iraq healthcare settings. The study was carried out from 4^th November 2023 to 20^th January 2024. …

Electrochemical Behavior Of Dental Alloys After Surface Modification By Sputtering Coating Technique, Noor Muneerabdulsahib, Nidhal Sahib Mansoor, Muna Noori Ismail

Hilla University College Journal For Medical Science

For metallic materials, the corrosion behavior is the most important property to be considered due to the biocompatibility and cytotoxicity of the products of the corrosion process in vivo. Numerous coating processes have been developed to improve corrosion resistance, enhance the metal’s surface qualities, and increase its service life. The purpose of this review was to gather data on the corrosion of alloys in dentistry and plasma sputtering coating techniques to improve the surface characteristics of substrates. Several databases, including google scholar, pubmed, science direct, and web of science were searched electronically, and a manual search of the scientific literature …

Risk Factors For Hepatitis B Virus Infection Among Patients Attending Health Facilities In Sulaimani City, Iraq: A Case-Control Study, Bestun Ibrahim Hama Rahim

Hilla University College Journal For Medical Science

Background: The hepatitis B virus is a major threat to public health because it causes disease. Approximately 5% of people worldwide are chronically infected, and this virus has infected approximately one-third of the population. The purpose of this study was to assess the risk factors for hepatitis B transmission among patients who visit medical institutions in Sulaimani City.

Method: A case-control study was carried out among 240 individuals (120 cases and 120 controls) visiting health facilities in Sulaimani City between August 11 and December 31, 2024. Convenient sampling was used for selecting participants. Data on demographics, behavioural risk factors, and …