Digital Commons Network^™

Investigation Of Regulated Cell Death (Rcd) Modalities Induced By Copper(Ii), Manganese(Ii) And Silver(I) Complexes Containing Bridging Dicarboxylate And 1,10-Phenanthroline Ligands, Ella O'Sullivan

Doctoral

With the increasing global cancer burden in recent years, there is an urgency to develop novel chemotherapeutic agents. Transition metal complexes represent an attractive class of candidates, owing to their unique electronic and stereochemical properties, as well as their capacity for ligand exchange, redox activity, and catalytic reactivity. These characteristics enable cellular signalling mechanisms that lead to tumour cell cytotoxicity via regulated cell death (RCD) mechanisms. The conventional RCD mechanisms of apoptosis and autophagy are attractive targets for the development of novel complexes because tumour cells evade apoptosis but use autophagy as a survival mechanism when under stress. Therefore, novel …

Context Matching Is Not Reasoning When Performing Generalized Clinical Evaluation Of Generative Language Models, Andrew Wen, Qiuhao Lu, Yu-Neng Chuang, Guanchu Wang, Jiayi Yuan, Jiamu Zhang, Liwei Wang, Sunyang Fu, Kurt D Miller, Heling Jia, Steven D Bedrick, William R Hersh, Kirk E Roberts, Xia Hu, Hongfang Liu

Faculty, Staff and Student Publications

Current discussion surrounding the clinical capabilities of generative language models(GLMs) predominantly centers around multiple-choice question-answer(MCQA) benchmarks derived from clinical licensing examinations. While accepted for human examinees, characteristics unique to GLMs bring into question the validity of such benchmarks. Here, we validate five benchmarks using eight GLMs, ablating for parameter size and reasoning capabilities, validating via prompt permutation three key assumptions that underpin the generalizability of MCQA-based assessments: that knowledge is applied, not memorized, that semantic consistency will lead to consistent answers, and that situations with no answers can be recognized. While large models are more resilient to our perturbations compared …

Context Matching Is Not Reasoning When Performing Generalized Clinical Evaluation Of Generative Language Models, Andrew Wen, Qiuhao Lu, Yu-Neng Chuang, Guanchu Wang, Jiayi Yuan, Jiamu Zhang, Liwei Wang, Sunyang Fu, Kurt D Miller, Heling Jia, Steven D Bedrick, William R Hersh, Kirk E Roberts, Xia Hu, Hongfang Liu

Faculty, Staff and Student Publications

Current discussion surrounding the clinical capabilities of generative language models(GLMs) predominantly centers around multiple-choice question-answer(MCQA) benchmarks derived from clinical licensing examinations. While accepted for human examinees, characteristics unique to GLMs bring into question the validity of such benchmarks. Here, we validate five benchmarks using eight GLMs, ablating for parameter size and reasoning capabilities, validating via prompt permutation three key assumptions that underpin the generalizability of MCQA-based assessments: that knowledge is applied, not memorized, that semantic consistency will lead to consistent answers, and that situations with no answers can be recognized. While large models are more resilient to our perturbations compared …

Comparing The Effectiveness Of Eggshell Spectra From Laser-Induced Break-Down Spectroscopy And Near-Infrared Spectroscopy Using Principal Compo-Nent Analysis To Determine The Authenticity Of Organic Eggs, Ahmad Qusthalani, Rara Mitaphonna, Muliadi Ramli, Rajibussalim Rajibussalim, Kurnia Lahna, Nasrullah Zaini, Nasrullah Idris

Makara Journal of Science

This study aimed to explore the potential of modern spectroscopy in the authentication of organic and non-organic chicken eggs using near-infrared spectroscopy (NIRS) and laser-induced breakdown spectroscopy (LIBS) spectra. A total of 175 eggs were analyzed, which were grouped into seven categories based on the source of feed given: 100% organic, 100% non-organic, 75% organic, 75% non-organic, 50% organic, free-range chickens, and eggs obtained from the local traditional market. Each group consisted of 25 eggs. NIRS spectra were recorded in the wavelength range of 350–2500 nm, whereas LIBS spectra were recorded in the range of 200–900 nm. A total of …

Information System To Elucidate Dna Sequencing Based On Machine And Deep Learning Techniques, Suhiar Mohammed Zeki Abd Alsammed

Baghdad Science Journal

The elucidation of DNA sequencing provides great importance in increasing the comprehension of organisms' genomic functions. However, the investigation of concealed structural information preserved within Deoxyribonucleic Acid (DNA) sequencing represents an outstanding challenge. Recently, machine and deep learning have become the techniques of preference for various tasks of genomics modeling, involving the prediction of genetic variation influence on the mechanisms of gene regulation like DNA receptivity and splicing. Therefore, this paper presented an information system for elucidating DNA sequencing data using diverse machine and deep learning techniques. In this system, two encoding methods are utilized for modifying the DNA sequencing …

Collagen Type Ii-Targeting Lentiviral Gene Therapy For Mucopolysaccharidosis Iva, Betul Celik, Sampurna Saikia, Shaukat Khan, Krishna Sai Musini, Shunji Tomatsu

Department of Pediatrics Faculty Papers

Mucopolysaccharidosis (MPS IVA) is caused by pathogenic variations in the GALNS gene, leading to the accumulation of glycosaminoglycans in tissues and causing progressive skeletal lesions. While conventional lentiviral vectors (LVs) provide long-term stable expression, they do not deliver therapeutic levels to bone and cartilage. We hypothesized that engineering the LV envelope with a collagen type II-targeting peptide (WYRGRL) increases the binding affinity of the LVs for bone and cartilage. These modified vectors carrying the CBh and COL2A1 promoters delivered the GALNS gene to MPS IVA newborn mice via intravenous (IV) or intraarticular (IA) administration. The peptide-modified LVs exhibited markedly increased …

Loss Of The Maternal Effect Gene Nlrp2 Impairs Embryonic And Extra-Embryonic Development, Revealing A Novel Genetic Cause Of Congenital Anomalies†, Momal Sharif, Zahra Anvar, Imen Chakchouk, Sara H El-Dessouky, Roni Zemet, Eric C Kao, Wessam E Sharaf-Eldin, Ying-Wooi Wan, Zhandong Liu, Pengfei Liu, Michael Jochum, Ignatia B Van Den Veyver

Duncan NRI Faculty and Staff Publications

Maternal-effect genes (MEGs) play a crucial role in early mammalian development, and their dysfunction can lead to severe embryonic and extra-embryonic abnormalities. NLRP2, a MEG that encodes a subcortical maternal complex (SCMC) protein, has been implicated in preimplantation development, but its role after implantation remains underexplored. In this study, we investigated the developmental consequences of maternal Nlrp2 loss-of-function in a maternal knockout (KO) mouse model at embryonic day 11.5. Embryos derived from Nlrp2-KO females have abnormal yolk sac vasculature, increased embryonic resorption, craniofacial abnormalities, neural tube defects, and congenital heart defects. Placental architecture is disrupted with an altered junctional zone …

A Spatiotemporal Model Of Cxcl10 As A Master Regulator Of Immune Evasion And Metastasis In Osteosarcoma, Benjamin B Gyau, Tsz-Kwong Man

Faculty, Staff and Students Publications

The C-X-C motif chemokine ligand 10 (CXCL10) is implicated in the progression of osteosarcoma (OS), the most aggressive pediatric bone malignancy. However, its role often presents a profound clinical paradox: although high circulating levels are strongly linked to poor prognosis, its canonical function is to recruit anti-tumor immune cells. This review unravels these contrasting roles by proposing a novel spatiotemporal model. We argue that in the early stages, immune-evading OS cells initiate the formation of a pre-metastatic niche (PMN) in the lungs, creating a localized inflammatory environment that becomes the primary source of elevated circulating CXCL10. As the disease progresses, …

Amino Acid Signaling In Skeletal Muscle Is Blunted By Prematurity In A Piglet Model, Antonio C Ramos Dos Santos, Agus Suryawan, Ki Beom Jang, Rosemarie D Parada, Mahmoud A Mohammad, Marta L Fiorotto, Teresa A Davis

Faculty, Staff and Students Publications

Background: Preterm (PT) infants are at increased risk for reduced postnatal lean mass accretion. We established that the feeding-induced stimulation of protein synthesis in skeletal muscle is blunted in piglets born PT compared with those born at term.

Objectives: We evaluated the extent to which key components of the amino acid-sensing pathways that regulate mechanistic target of rapamycin complex 1 (mTORC1) activation contribute to anabolic resistance in skeletal muscle of piglets born PT compared with those born term.

Methods: Piglets delivered by cesarean section 10 d PT (n = 23) or at term (n = 22) were administered total parenteral …

Spinal Cord Injury In The Context Of Major Motor Vehicle Collision Trauma: A Retrospective Ecological Analysis Of Global Estimates Across Income Groups, Tim Nutbeam, Jessica Caterson, Colleen J. Saunders, Hendry R. Sawe, Sabariah Faizah Jamaluddin, Ian Roberts, Jason E. Smith, Paulus Ambunda, Willem Stassen

Peninsula Medical School

Introduction: Road traffic injuries (RTIs) are a leading cause of death globally, especially in low- (LICs) and middle-income countries (LMICs). Despite this burden, post-crash care remains underdeveloped. Many clinical principles of post-crash care focus on spinal cord injury (SCI), yet its incidence is poorly understood. The aim of this study was to describe the incidence of death and non-fatal RTI with a specific focus on SCIs using Global Burden of Disease (GBD) 2019 data. Methods: A retrospective ecological analysis was conducted using GBD 2019 data for 204 countries and territories (2012–2019). We examined the MVC-related mortality, SCIs, and major non-fatal …

Standardizing Assessment Of Clinical Performance In Physical Therapy: From Good Intentions To Shared Standards, Arvie Vitente, Carmina Rafael, Rolando Lazaro

Philippine Journal of Physical Therapy

Clinical education is the crucible in which physical therapy students integrate knowledge, skills, and professional judgment into safe, ethical, and person-centered practice. Yet globally, the assessment of clinical performance remains highly variable, shaped by disparate tools, rubrics, and levels of assessor preparation. While several countries have adopted nationally standardized approaches to clinical assessment, many contexts—including the Philippines—continue to rely on locally developed or institution-specific systems, resulting in inconsistent expectations, inequitable student experiences, and limited capacity for benchmarking, research, and quality improvement. This editorial argues that good intentions alone are insufficient and that the profession must move toward shared, trustworthy standards …

Precision Education In Health Sciences Education: A Call-To-Action For Developing An Interprofessional Strategy, Arvie Vitente, Jennifer Bosworth, Robert Sweet, Rebecca Cozzi, Christopher Galloway, Piotr Szczurek, Melanie Obispo-Young, Eron Bozec, Erica Brkovic, Tina Bobo, Jennifer Lubinski

Philippine Journal of Physical Therapy

Introduction. Growing learner diversity, expanding biomedical knowledge, and rapid clinical digitization have exposed the limits of on-size-fits-all health sciences training. Competency-Based Education (CBE) has sharpened the focus on outcomes, yet many programs still move learners through fixed sequences, infrequent assessments, and retrospective remediation. Precision Education (PE) offers a complementary, data-enabled approach that uses learning analytics, artificial intelligence (AI), and continuous feedback loops. Embedded within CBE, PE converts competencies from static milestones into dynamic trajectories that can be measured, visualized, and adjusted in real time across the curriculum. This abstract highlights the need for an interprofessional strategy to design, fund, and …

Supply Chain Network Based On Blockchain And Intelligent Agent, Hiba Hamdi Hassan, Rana Fareed Ghani

Journal of Soft Computing and Computer Applications

In agricultural supply chains, the complexity and indeterminacy pose serious challenges to traceability, reliability and confidence today. This challenge is especially acute in the olive oil industry where adulteration, wrong labeling, and uneven chemical quality threaten the actual well-being of producers and consumers. The project aims to design a blockchain-based hybrid architecture with intelligent agents (FNNs) to enhance transparency, reliability and responsiveness in the olive oil supply chain. The Blockchain component enables a completely open, tamper-proof ledger to be built in a very decentralized way and preserved as an archive of every account of its transactions. The intelligent agents contribute …

Tax Trends, E. S. Linett

Tax Adviser

No abstract provided.

Tax Clinic, Peter Elder

Tax Adviser

No abstract provided.

Estate Planning: Significant Recent Developments Concerning Estate Planning (Part I), Byrle M. Abbin, Robert H. Daskal, David K. Carlson

Tax Adviser

No abstract provided.

Tax Trends, E. S. Linett

Tax Adviser

No abstract provided.

The Tax Adviser, Volume 5, Number 11, November 1974, American Institute Of Certified Public Accountants

Tax Adviser

No abstract provided.

Tinig-Karakter Sa Mga Pader: Graffiti, Bandalismo, At Mga Banyulatin Sa Piling Panitikang Filipino (Character-Voices On Walls: Graffiti, Vandalism, And Latrinalia In Select Philippine Literature), Harvey James G. Castillo

Filipino Faculty Publications

Makailang beses lilitaw sa tradisyonal na midya at social media sa nagdaang kalahating dekada ang ilang pagtutol, pagbabawal, at pandidiri sa mga graffiti at nagsusulat ng mga graffiti mula sa parehong mamamayan at maykapangyarihan. Bunsod ng paggamit ng mga militanteng grupo sa graffiti bilang anyong pamprotesta sa Kalakhang Maynila, tatagurian ng nakararami ang gayong mga sulatin bilang bandalismo o paninira lamang sa pampubliko o pribadong pagmamay-ari. Taliwas ito sa balintunang paggamit din ng estado at merkado sa graffiti, o estetika ng graffiti, sa pamamahala ng espasyo o pagbebenta ng produkto. Sa ganang ito, bumabaling ang pag-aaral sa panitikan bilang lunan …

Robinson Jeffers' Roan Stallion, Tamar And Other Poems: Centennial Reflections, Rja

Jeffers Studies

No abstract provided.

Comparative Transcriptomics Reveals Novel And Differential Long-Noncoding Rna Responses Underlying Interferon-Mediated Antiviral Regulation In Porcine Alveolar Macrophages, Jiuyi Li, Oluwaseun Adeyemi, Laura C. Miller, Yongming Sang

Food and Animal Sciences Faculty Research

Porcine reproductive and respiratory syndrome virus (PRRSV) is a major threat to the global swine industry. Long non-coding RNAs (lncRNAs) are emerging as crucial regulators of antiviral immunity, but their roles in porcine alveolar macrophages (PAMs)—the primary target of PRRSV—remain poorly characterized. This study presents a genome-wide analysis of lncRNA expression in PAMs stimulated with a PRRS modified live virus (MLV) vaccine and two type I interferons, IFN-α1 and IFN-ω5. Whole-transcriptome sequencing identified over 2000 differentially expressed lncRNAs, with IFN-ω5 inducing the most extensive transcriptional reprogramming. Weighted gene co-expression network analysis (WGCNA) revealed interferon-specific lncRNA-mRNA modules, and functional enrichment showed …

State Of California Cannabis Reporting, University Of Mississippi – National Center For Cannabis Research And Education

California

No abstract provided.

Standardizing Assessment Of Clinical Performance In Physical Therapy: From Good Intentions To Shared Standards, Arvie Vitente, Carmina Rafael, Rolando Lazaro

Rehabilitation Sciences Department Faculty Articles

Clinical education is the crucible in which physical therapy students integrate knowledge, skills, and professional judgment into safe, ethical, and person-centered practice. Yet globally, the assessment of clinical performance remains highly variable, shaped by disparate tools, rubrics, and levels of assessor preparation. While several countries have adopted nationally standardized approaches to clinical assessment, many contexts—including the Philippines—continue to rely on locally developed or institution-specific systems, resulting in inconsistent expectations, inequitable student experiences, and limited capacity for benchmarking, research, and quality improvement. This editorial argues that good intentions alone are insufficient and that the profession must move toward shared, trustworthy standards …

Biomechanics Of The Ribs During Respiration At The Costotransverse Joint: An In-Vivo Retrospective Pilot Study, Michael Maninang, Greg Almeter, Erik Pearson, Arvie Vitente

Rehabilitation Sciences Department Faculty Articles

Introduction: Scarce in‑vivo data describe how ribs move at the costotransverse joints during quiet breathing—knowledge critical to thoracic biomechanics and pain mechanisms. This pilot study uses four‑dimensional computed tomography (4D‑CT) to quantify, for the first time, the three‑dimensional magnitude and direction of rib motion at these joints throughout quiet respiration.

Methods: This retrospective, descriptive pilot study analyzed ten 4D‑CT scans obtained from patients undergoing thoracic imaging prior to radiation therapy. End‑expiration and end‑inspiration phases were aligned with a demons deformable‑registration algorithm. For each costotransverse joint, the three‑dimensional displacement vector, its absolute magnitude, and its components along the lateral–medial (L–M), …

Sex Differences In The Association Of Vascular Risk And Apoe Genotype With Cognitive Decline And Dementia: Evidence From A U.S. Longitudinal Study, Longjian Liu, Jintong Hou, Saishi Cui, Xiaopeng Zhao, Zuolu Liu, J. Craig Longenecker, Nathalie S May, Jin Jun Luo, Rose Ann Dimaria-Ghalili, Howard J. Eisen

Division of Cardiology Faculty Papers

BACKGROUND: Sex differences in the association between vascular factors and cognitive outcomes remain unclear. We aimed to investigate the associations of blood pressure metrics (hypertension, systolic blood pressure [SBP), pulse pressure, ankle and brachial pressures, and ankle to brachial pressure index [ABI]) with the risk of cognitive decline and dementia.

METHODS: We conducted a population-based longitudinal analysis using data from the Atherosclerosis Risk in Communities (ARIC) study (begun in 1987-1989) in the United States. We analyzed a total of 12,268 participants aged 45-64 years who had validated exposure measurements, cognitive function tests (first administrated 1990-1992), and followed up for incidence …

How Youth Think About Structural, Individual, And Random Sources Of Wealth Inequality, Amanda R. Burkholder, Riley N. Sims, Melanie Killen

Open Access Fund Publications

This study investigated how youth evaluate wealth inequalities, and whether youth differentiate structural, individual, and random explanations for why such inequalities exist. Understanding these distinctions is necessary for addressing exclusionary attitudes, biases, and discriminatory behaviors that emerge in childhood which have deleterious outcomes for youth. The present study included 262 youth (56.1% female; 27% Black, 49% White, 6.5% Asian American or Pacific Islander, 6% Latine, 6% multiracial, 6% other) who were 9 to 14-years-old, living in the Mid-Atlantic region of the U.S., and from primarily middle to high-middle income backgrounds. Participants evaluated wealth inequalities of different causes, reasoned about their …

Hospital–Medicare Advantage Vertical Integration And Cardiopulmonary Care In Integrated Hospitals, Geronimo Bejarano, Meehir N. Dixit, Alexander P. Philips, Karen E. Joynt Maddox, Meredith B. Rosenthal, Amal Trivedi, David J. Meyers

2020-Current year OA Pubs

No abstract provided.

Tumor Biology And Access To Care And Metastatic Breast Cancer Outcomes, Matthew R. Dunn, Sarah C. Van Alsten, Marc A. Emerson, Katherine Reeder-Hayes, Terry Hyslop, Melissa A. Troester

Kimmel Cancer Center Faculty Papers

PURPOSE: To understand how access to care influences metastatic breast cancer burden (MBC) while accounting for molecular tumor characteristics, and identify interventions to reduce metastatic disease burden.

METHODS: The Carolina Breast Cancer Study is a population-based cohort with invasive breast cancer (diagnosed 2008-2013). Both de novo metastasis (stage IV at diagnosis) and distant recurrence were evaluated (12 years of follow-up. Tumor data were from medical records, pathology reports, and RNA expression data. Social variables and access to care were from participant surveys. Generalized linear models were used to estimate associations of biological and access characteristics with MBC; Cox models were …

Classifying Glaucoma Disease Images Via Deep Neural Network Technique, Maysoon Jaaffar Rahim, Ali Abid Dawood Al-Zuky, Fatin Ezzat Muhy Al-Dean Al-Obaidi

Baghdad Science Journal

A class of eye diseases known as glaucoma refers to a category of eye disease which is often associated with increased intraocular pressure, and can damage the eye by destroying nerve cells in the retina in addition to the eye's optic nerve. The accuracy of diagnosing glaucoma eye disease depends on the knowledge and experience of the ophthalmologist. Therefore, the need for automatic feature extraction from the retinal image is crucial for the diagnosis of glaucoma eye disease. The current article introduces a multi-layer deep neural network model with convolution and classification layers. The originality of the current search focuses …

Enhancing Patient Experience In Indian Healthcare: A Key Component For Successful Medical Tourism, Elizabeth G. Clark, Elizabeth Ziemba

Visions in Leisure and Business

Post-pandemic, Indian hospital chains have been increasingly expanding their bed capacity, either by constructing new hospitals or acquiring existing healthcare infrastructure in select markets. (1, 2,) A frequent strategy cited for attracting both domestic and international patients is “medical tourism” or “medical value travel.” This paper examines the concept of patient experience and argues that, for India to become a competitive medical tourism destination, hospital operators must prioritize the development and enhancement of patient experience initiatives. By focusing on the quality of patient interactions and care, Indian hospitals can better attract patients from abroad while ensuring sustainable growth and improved …