Digital Commons Network^™

Patient-Related Factors Influencing Delays In Oral Cancer Diagnosis: Insights From Pakistan, Muhammad Usman Amanat, Hutcha Sriplung, Duangporn Kerdpon

Journal of Dental Sciences

Background/purpose South Asia has a high burden of oral cancer (OC); however, delays in diagnosis remain under-researched. The study investigated delay intervals in OC diagnosis and the contributing factors in rural Pakistan, considering its unique sociocultural context. Materials and methods This multi-center cross-sectional study employed a structured questionnaire to interview 152 oral squamous cell carcinoma (OSCC) patients. The diagnostic intervals were determined using the Aarhus Statement. Logistic regression assessed the association between independent factors and delay types. Results Patient delays occurred in 76.3 % of cases, mostly due to appraisal delays (65 %), while diagnostic delays appeared in 51.3 %. …

Relationship Between Tooth Loss And Tongue Pressure And The Effectiveness Of Removable Denture For Older People Requiring Long-Term Care, Madoka Funahara, Yuki Sakamoto, Haruka Oyama, Sakiko Soutome

Journal of Dental Sciences

Background/purpose Aspiration pneumonia is a major health concern among older adults, particularly those requiring long-term care. It is often caused by silent aspiration of saliva-containing pathogenic bacteria and exacerbated by impaired oral and swallowing functions. Tongue pressure is a key factor in maintaining these functions, and its decline is associated with increased bacterial amount in the saliva and higher mortality. However, the relationship among tongue pressure, occlusal status, and prosthetic treatment in older individuals requiring care remains unclear. This study aimed to investigate the association between tooth loss and decreased tongue pressure in older individuals requiring long-term care, and to …

Improvement In Oral Hygiene Among Bedridden Patients Following Domiciliary Dental Care: A Retrospective Study, Min Yee Ng, Chuan-Hang Yu

Journal of Dental Sciences

Background/purpose Domiciliary dental care (DDC) offers dental services in the comfort of a patient's home, typically for bed-bound patients. Poor oral hygiene in this group has been associated with pneumonia. Although DDC reduces the risk of pneumonia, its impact on oral hygiene has not been explored yet. Therefore, this retrospective study aimed to investigate the effectiveness of DDC in improving oral health in bedridden patients. Materials and methods We retrospectively reviewed individuals who received dental services and evaluated their oral hygiene status using the plaque index (PI). Demographic data (age, sex, cause of bedridden state) and oral findings (DMFT, number …

Challenges And Best Practices For The Development Of Coastal Hazard Decision Support Tools, Noah Hallisey

Open Access Dissertations

There is growing interest in developing Decision Support Tools (DSTs) supporting emergency managers and other decision-makers during coastal storm events. Yet many tools fail to inform decision-making due to challenges associated with their development and transition into operational tools for real-time decision-making. This dissertation investigates these challenges and offers best practices for their development and implementation for real-world decision-making through a literature review, interviews with subject matter experts in the United States, and a real-world case study.

Manuscript 1 reviews existing published literature to understand whether and how tool developers are incorporating emergency managers in the development of DSTs and …

Assessing Sandfly & Mosquito Abundance, Richness, And Diversity In Villaflora, Ecuador: Linking Disease Vectors To Disease Risk, Carlia Rose Lopez

Student Scholarship

No abstract provided.

Great Power Competition In Africa: Sustaining Openness Amidst Transnational Threats And Authoritarian Fragmentation, Chick Edmond

Political Science & Geography Faculty Publications

As the United States seeks to position itself in an increasingly competitive world, Africa has emerged as an increasingly key arena of great power competition where the United States, China, and Russia are competing to determine the nature of political norms, economic governance and security architecture on the continent.

The combination of growing transnational threats (such as terrorism, pandemics, climate-related instability, and digital vulnerability), and growing authoritarianism, has transformed the continent into a testbed for competing visions of international order. In light of this backdrop, this paper posits that the United States must pursue a strategy of sustained strategic openness …

The Evolving Beijing Consensus: Chinese Communist Party Political Control And Economic Trade Offs, Ian Murphy

Political Science & Geography Faculty Publications

China’s rapid economic rise and unique development trajectory have long been the subject of scholarly debate, often framed through the concept of the “Beijing Consensus” as an alternative to the Washington Consensus. While initial conceptualizations highlight innovation, sustainability, and national sovereignty, later analyses highlighted elements like state capitalism and authoritarianism, particularly in the wake of the 2008 Global Financial Crisis. This paper argues that the Beijing Consensus is undergoing a significant evolution under Chairman Xi Jinping, increasingly prioritizing the Chinese Communist Party’s political security, regime stability, and ideological control at the expense of economic growth. This marks a notable departure …

Evidence-Based Policymaking And Global Governance: An Examination Of The Role Of The Policy Studies Organization And Ecosoc, Chick Edmond

Political Science & Geography Faculty Publications

Transnational challenges, such as climate change, global inequality, pandemics, digital governance, and institutional legitimacy crises, are becoming increasingly complex, therefore, the demand for evidence-based decision-making has become an important developing normative and practical issue in the area of global governance. The Economic and Social Council (ECOSOC) is the principal organ of the UN responsible for coordinating policy processes across all areas of economic, social and development issues. However, despite ECOSOC’s ability to make decisions concerning how the world addresses these problems, it has been widely criticized for being unable to translate expert knowledge into tangible policy outcomes. Therefore, this paper …

How Autistic Children Define Novel And Real Words, Henry James Tomiser

Graduate Research Theses & Dissertations

Word knowledge is highly valuable to Autistic individuals, and although much research has characterized Autistic children’s vocabulary breadth (i.e., the number of lexical entries), less attention has been paid to vocabulary depth (i.e., the richness with which one understands a given word). In this exploratory post-hoc study, 11 Autistic children (one assigned female at birth) participated in novel and real word learning paradigms in which child-friendly referents were paired with CVCV word forms. Participants were then asked to provide open-ended definitions of the words. Definitions were parsed into meaningful subunits, or semantic features. Semantic features were coded by type of …

Exploring Factors Predicting Teachers’ Intentions To Use Digital Games In Saudi Elementary Schools, Thamarah M. Alqahtani

Graduate Research Theses & Dissertations

Despite the potential benefits of integrating digital games in teaching and learning environments, little research has been carried out to understand the perception of elementary school teachers in the Kingdom of Saudi Arabia (KSA) towards integrating digital games into the classroom. This study aims to understand Saudi elementary teachers’ intention of using the digital games in elementary school classrooms using Theory of Planned Behavior (TPB) model, and to provide crucial insights for the KSA’s Ministry of Education’s (MOE) administrators in developing evidence-based teacher training and effective school technology-integration policies. The Theory of Planned Behavior (TPB) was used to assess Saudi …

Influence Of Parental Immigration On Children Of Latino Immigrants’ Attachment And Substance Use, Leilanis Cancel-Lopez

Graduate Research Theses & Dissertations

This study aimed to explore how children of Latino immigrants described their attachment and substance use experiences. The narrative that formed implies that throughout their adolescence, children of Latino immigrants use substances in part to cope with their parents’ heightened expectations for the participants to perform well in school/work/life. Additional results find that children of Latino immigrants also form a sense of exoneration for their parents upon reaching young adulthood. Clinical implications include the use of a systemic perspective when approaching children of immigrants when treating substance use and the inclusion of this narrative when creating prevention strategies for immigrant …

Madness In The Mixtape: Gothic Literature And Pop Music, Nicholas Dertinger

Graduate Research Theses & Dissertations

In Gothic literature, madness has often been connected to the outliers of what is considered socially normal. This dissertation explores the enduring theme of madness, particularly the figure of the “madwoman,” in both women’s literature and in its “afterlife”—or continuing conversation with—contemporary pop music. Through a comparative analysis of songs including Kate Bush’s “Wuthering Heights” (1978), Beyoncé’s “Hold Up” (2016), Lady Gaga’s “Plastic Doll” (2020), Olivia Rodrigo’s “good 4 u” (2021), Billie Eilish’ “What Was I Made For?” (2023), Paramore’s cover of “Burning Down the House” (2024), Taylor Swift’s “mad woman” (2020) and Florence + the Machine’s “Dream Girl Evil” …

Testing A Self-Affirmation Intervention To Increase The Likelihood Of Seeking Emotional Social Support, Selena Heinlein

Graduate Research Theses & Dissertations

Needing help is a common occurrence in the everyday lives of many people. Seeking help, however, is not. Even though most people experience needing help regularly, many people do not ask for help. Not asking for help when it is needed may be caused by several factors. Some people may not ask for help because they think it is going to be awkward, while others may not ask for help because they think they are going to be negatively perceived by others. These fears may get worse when needing to seek emotional social support for a personal issue, since this …

Effects Of Desiccation On Invasive Faucet Snail (Bithynia Tentaculata) And Trematode Survival, Elise Marie Jordahl

Graduate Research Theses & Dissertations

Parasitism is one of the most common and diverse life history strategies, yet relatively little is known about the role of parasites as invasive species. Invasive species, which present one of the greatest threats to biodiversity, often need to overcome adverse environmental conditions as they establish and spread in new habitats. Invasive parasites are subject to these same conditions, though the effects may be mediated through their hosts. Here, I use an invasive snail and its trematode parasites to quantify the effects of desiccation on survival to better understand how processes of invasion play out in host-parasite systems. The faucet …

Hot Topic Of The Cold War: Analyzing The Bomb In American Media During The Late Twentieth Century, Ryan Lambert

Graduate Research Theses & Dissertations

This thesis explores nuclear war–related media (i.e., media involving “the Bomb”) from the late twentieth century, beginning in the early 1950s and ending in the late 1990s, although media from the 2000s and beyond are briefly touched on. Unlike other studies of nuclear war narratives, this analysis intends to explore this media through a rhetorical framework of an “eroding” society, and the “erosion” concepts of the 50s–70s paved the way for cumulative “erosion” storylines in the 80s (the height of the Cold War), and then “restoration” storylines in the 90s (after the end of the Cold War). This framework is …

Photovoice Exploration Of Afghan Refugee Background Women's Food-Related Well-Being, Eileen C. Lindemann

Graduate Research Theses & Dissertations

More than 117,000 Afghans have been relocated to the United States following the U.S. military withdrawal in August 2021. Research indicates that Afghan refugees resettled in the U.S. are at increased risk of psychological distress, with Afghan women particularly susceptible compared with Afghan men, and diet-related chronic disease. However, research also shows that traditional food and eating customs foster cultural identity, social support, integration, and well-being. The purpose of this study was to collaboratively explore the food-related well-being and daily life contexts of resettled refugee participants through the photovoice method, a participatory research strategy in which participants photograph aspects of …

Personality Theories, Leswin Laubscher

Open Education Materials

Introduction to Personality Theories

Implementation Of The Downes Scoring Tool, Jennifer Oney

Doctor of Nursing Practice (DNP) Scholarly Projects

Background

Respiratory Distress Syndrome (RDS) is a leading cause of morbidity and mortality in premature infants. It is managed with continuous positive airway pressure (CPAP), but CPAP can mask the signs of RDS, and delay surfactant therapy.

Purpose

This quality improvement project (QI) was to assess healthcare providers’ confidence in RDS and surfactant therapy through pre- and post- surveys and provided education on RDS and the implementation of the Simplified Downes Scoring Tool to assess respiratory distress in premature infants (25-36 weeks gestation).

Methods

In a Level III NICU, healthcare providers received education on RDS and the scoring Tool, they …

Impact Of Fast Track On Emergency Department Length Of Stay, Kayce Carrick Bsn, Rn, Kelsey Richmond Rn, Stacy Duncan Rn

Nurse Residency Posters

Facilitator: Melissa Harper, BSN, RN

OhioHealth O'Bleness Hospital

Impact Of Exercise And Cognitive Behavioral Therapy On Anxiety And Depression, Ranjita Subedi, Rachel Affeldt, Abigail Bentley, Gavin Gump, Madison Mitchell, Taylor Rodgers, Bayley Mullins, Libbie Woodland, Sophia Rubenkoenig

Nurse Residency Posters

OhioHealth Grant Medical Center

Hands-Free Tech For Fall Prevention, Sierra Dixon Rn, Jessica Gillam Rn, Bryan Hatheway Rn, Taightam Hicks Bsn, Rn, Kelsey Tignor Bsn, Rn, Hailie Tomsik Rn, Jeremiah Waworoendeng Rn

Nurse Residency Posters

Facilitator: Kasey Gillen, MHA, BSN, RN, NPD-BC

OhioHealth Mansfield Hospital

Impact Of Intentional Leadership Styles On Staff Nurse Satisfaction And Retention, Monica Patrick Rn, Camie Mitchell Rn, Amelia Kennedy Rn, Rachel Geiger Rn, Zachary Foster Rn, Katherine Leahy Rn

Nurse Residency Posters

Facilitator: Tess Wagner, BSN, RN

OhioHealth Riverside Methodist Hospital

Air Quality Risks In Public Housing, Brynn Sheehan, Carolyn Caraballo Velez, Vaughan W. Rees, Miasha T. O'Neal, Kristen E. Moore, Katie M. Jones, Jessica Meadows, Sarah Gehlert, Richard Grucza, Andrew Plunk, Kelli J. England

Department Psychiatry & Behavioral Science Faculty Publications

Importance Public housing residents face elevated environmental health risks, yet indoor air quality in these settings remains underexamined. OBJECTIVE: To evaluate indoor air quality in public housing 5 years after implementation of the federal smoke-free housing policy and compare it with outdoor air quality in the same regions.

Design, Setting, and Participants A 1-year cohort study of indoor air quality (particulate matter ≤2.5 μm in diameter [PM2.5]) across 12 multifamily public housing communities in southeastern Virgina for individuals 65 years and older or persons with disability in cities with the highest rated outdoor air quality. Indoor PM2.5 was continuously measured …

Medical Image Feature Extraction And Selection Based On Inception V3 And Gini Index For Cervical Cancer Cells Identification, Rachida Assawab, Mounir Ouzir, Badreddine Benyacoub, Abderrahim Electrochemical Sensor For Tenofovir Allati, Ismail El Moudden

Research and Infrastructure Service Enterprise (RISE) Faculty Publications

Background: Cervical cancer remains the fourth most common cancer in women globally, with 604,000 new cases annually. Early detection through cytological screening is critical, but manual interpretation suffers from high false negative rates and requires expert pathologists often unavailable in resource-limited settings.

Methods: We developed a novel hybrid framework combining InceptionV3-based deep feature extraction with Gini Index feature selection for automated cervical cancer cell classification. Using the Herlev dataset (917 Pap smear images: 242 normal, 675 abnormal), we extracted 2048 deep features and applied systematic feature selection to identify optimal discriminative subsets. Comprehensive clustering analysis (K-means, K-medoid, Fuzzy clustering) validated …

Hu308, A Selective Cannabinoid Type-2 Receptor Agonist, Mitigates Sars-Cov-2 Spike Protein-Induced Acute Lung Injury In Mice, Janette Lockett, Gregory Nicholson, Nicholas Richards, Ryan Washington, Nagaraja Nagre

Department of Biomedical and Translational Sciences Faculty Publications

Introduction

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to pose major health challenges despite effective vaccination efforts. The sustained occurrence of breakthrough infections and emerging variants of the virus highlights the need for additional therapeutic strategies. Given the anti-inflammatory role of the cannabinoid type 2 receptor (CB2R), we examined the effect of CB2R activation in SARS-CoV-2 spike protein subunit 1 (S1SP)-induced acute lung injury (ALI).

Methods

ALI was induced in mice by intratracheal (i.t.) administration of S1SP, followed by treatment with the CB2R agonist HU308 (5 mg/kg, intraperitoneal: i.p.) 1 h …

P38 Mapk Is Involved In Epigenetic Regulation Of Fibrotic Genes In Replication Induced Senescence In Lung Fibroblasts, Shan Zhu, Jennifer Q. Zhou, Kan Wang, Ming-Lei Guo, Yan Sanders

Department of Biomedical and Translational Sciences Faculty Publications

Fibroblast activation is essential for tissue repair following injury; however, prolonged activation drives pathological fibrosis. Idiopathic pulmonary fibrosis (IPF), a progressive and age-associated lung disease, is characterized by aberrant fibroblast activation, with increasing evidence implicating senescent and near-senescent fibroblasts in its pathogenesis. However, the underlying mechanisms remain poorly defined. In this study, we investigated whether histone modification is involved in TGF-β1 treated lung fibroblasts and contributes to the fibrotic phenotype. Human IMR90 lung fibroblasts at low and high population doubling levels (LPDL and HPDL), as well as primary IPF fibroblasts, were used in this study. In response to TGF-β1, both …

Deletion Of Stim1 In Treg Cells Protects Against Lung Fibrosis And Associated Cardiovascular Complications In A Pre-Clinical Mouse Model, Nagaraja Nagre, Balaji Srinivas, Nicholas Richards, Ryan Washington, Gregory Nicholson, Yan Sanders, Beata Kosmider, Khalid Matrougui

Department of Biomedical and Translational Sciences Faculty Publications

Idiopathic pulmonary fibrosis (IPF) is a progressive and incurable lung disease characterized by excessive tissue remodeling and impaired gas exchange. Evidence highlights the critical interplay between immune regulation, calcium signaling, and redox biology implications in the pathogenesis of fibrotic lung disease. Regulatory T-cells (Tregs), known to modulate cardiovascular and immune function, are diminished in IPF, contributing to inflammation and tissue damage. Here, we demonstrate that the stromal interaction molecule 1 (STIM1), a key regulator of intracellular calcium homeostasis, is significantly upregulated in Treg cells isolated from IPF patients and mice subjected to bleomycin-induced lung injury. This upregulation is associated with …

Senescent Fibroblasts In Aging And Pulmonary Fibrosis, Sara B. Palega, Aiwei Y. Borengasser, Yan Y. Sanders

Department of Biomedical and Translational Sciences Faculty Publications

Aging is a major risk factor for many chronic lung diseases, including Idiopathic Pulmonary Fibrosis (IPF), a fatal and incurable disease characterized by progressive fibrotic remodeling. Age-associated structural alterations, impaired regenerative capacity, and dysregulated cellular signaling collectively create a pro-fibrotic microenvironment. A central driver of this pathological shift is the accumulation of senescent cells, which undergo irreversible growth arrest and develop a robust pro-inflammatory senescence-associated secretory phenotype (SASP). Emerging evidence identifies senescent lung fibroblasts as critical mediators of IPF pathogenesis. These cells promote excessive extracellular matrix deposition, myofibroblast differentiation, and tissue stiffening, while simultaneously impairing epithelial regeneration. Together, these effects …

Lipid And Foam Cell Accumulation As Novel Pathological Features Of Benign Prostatic Hyperplasia, Dita Julianingsih, Samara V. Silver, Thaissa Horne, Kasun Gunawardena, Savannah Ward, Alicia Malewska, Douglas Strand, Julius Nyalwidhe, Ilya Sobol, Petra Popovics

Department of Biomedical and Translational Sciences Faculty Publications

Background

Benign prostatic hyperplasia (BPH) encompasses a heterogeneous set of pathological processes that instigate lower urinary tract symptoms (LUTS). Using a mouse model of steroid hormone imbalance-induced lower urinary tract dysfunction, we identified luminal lipid-laden foamy macrophages, although their presence and contribution to human pathology have not yet been established. The objective of this study was to determine whether luminal macrophages are associated with human BPH and to assess how lipid accumulation relates to underlying pathological features and clinical parameters.

Methods

Whole-mount tissue sections from simple prostatectomy specimens and prostates from healthy donors were used to evaluate the association of …

Supramolecular Self-Assemblies Of Ru( Ii ) Phototherapeutics: Biological Activity Of Micro- And Nano-Particles Acting As Reservoirs, Jérôme Laisney, Sarah M. Kriger, Dmytro Havrylyuk, Jason M. Unrine, David K. Heidary, Edith C. Glazer

Chemistry Faculty Publications

Ruthenium( II) coordination complexes have many appealing properties as prodrugs, but can suffer from poor aqueous solubility and short circulation times, drastically decreasing efficiency in vivo. Nanoformulations using a variety of carriers, such as inclusion in polymers/lipids or adsorption on inorganic nanoparticles have been applied to overcome this limitation, but unfortunately, these approaches raise additional concerns regarding the fate of the carriers, with potential long-term toxicity and accumulation in vital organs. Here, we present an alternative delivery strategy with formation of pure and polymer-supported supramolecular self-assemblies of Ru(II) complexes acting as ‘‘reservoirs’’. A facile preparation of size-controlled particles was achieved …