Digital Commons Network^™

Prevalence, Perception, And Prevention: Tobacco And Nicotine Use Amongst Middle And High School Students, Samantha Fischer

Schultz-Werth Award Papers

This study examines data from a survey conducted with South Dakota middle and high school principals about tobacco and nicotine use on school grounds and school district tobacco policies. The project was implemented through the South Dakota State University Population Health Evaluation Center and was sponsored by the South Dakota Department of Health Tobacco Control Program. Over 1.58 million high school students and 640,000 middle school students reported using some type of tobacco product in a 2024 report (United States Food and Drug Administration (FDA), 2024). Of the middle and high school students who previously used tobacco products sometime in …

Spanish Speakers And Healthcare: Experiences And Perceptions, Ainsley Boucher

Schultz-Werth Award Papers

The Spanish-speaking population in the United States is large and diverse. As such, individual perceptions regarding healthcare access and quality held by native Spanish speakers vary widely. In order to provide insight into local healthcare access, a customized survey was developed and distributed to a workplace in the Brookings area. Responses varied considerably, reflecting a diversity of experiences and perceptions. Determinants such as language barriers, occupational health risks, and various socioeconomic factors may affect healthcare access and quality for native Spanish speakers in the United States.

The Dietary Burden Of Phosphorus And Aluminum In Ready-To-Eat Wheat Flour Tortillas Exceeds That Of Corn Tortillas: Implications For Patients With Chronic Kidney Disease, Kate Chander Chiang, Robert Yokel, Jason M. Unrine, Kamyar Kalantar-Zadeh, Ajay Gupta

Pharmaceutical Sciences Faculty Publications

Background: Ready-to-eat, shelf-stable tortillas contain several phosphorus- and aluminum-containing additives that may increase the risk of adverse events in patients with chronic kidney disease (CKD).

Objective: The present study aimed to measure the dietary aluminum and phosphorus burden in store-bought corn and wheat flour tortillas. Design: This cross-sectional study analyzed the elemental content of commercially available corn and wheat flour tortillas collected from 2019 to 2020.

Setting: Twenty-one elements were quantified by ICP-MS and ICP-OES from 14 corn and 13 wheat flour tortilla brands purchased from local supermarkets in Southern California in 2019–2020.

Statistical analyses performed: Multiple group comparisons were …

Altered Bile Acid Transport In Liver Disease, Sarah Cayton, Lindsay C. Czuba

Pharmaceutical Sciences Faculty Publications

Background/Objectives: Bile acids, synthesized from cholesterol in the liver, are amphipathic molecules that play an integral role in lipid digestion and absorption, while also serving as systemic endocrine hormones. They continuously undergo enterohepatic circulation, where they interact with various transporter proteins. Dysregulated bile acid transport is associated with the pathogenesis of liver disease. This review summarizes the key findings relating to bile acid transport expression and activity in the pathogenesis of liver disease.

Methods: A review of the literature was performed using PubMed and relevant terms including, but not limited to, “bile acid transporters”, “liver disease”, and “bile acid uptake …

Chronic Alcohol Consumption Disrupts The Gut Microbial And Metabolic Landscapes, Madison B. Blanton, Ethan G. Napier, Katelyn E. Keen, Ethan V. Stuart, Isaac R. Cinco, Hami Hemati, Ronald C. Bruntz, Landon Wilson, Stephen Barnes, Rupak Khadka, Kathleen A. Grant, Ilhem Messaoudi

Pharmaceutical Sciences Faculty Publications

Introduction: Alcohol use disorder (AUD) increases incidence of infections, organ damage, and cancers. Aberrant inflammation is likely a driver of these adverse outcomes. Indeed, chronic alcohol consumption (CAC) rewires macrophages/monocytes toward a hyper-inflammatory phenotype. Prior studies showed increased gut permeability and dysbiosis. Translocation of host- and microbial-derived metabolites could trigger the hyper-inflammatory responses generated by macrophages/monocytes. However, the exact changes in these metabolites remain poorly defined due to confounders that complicate clinical studies and the differences between human and rodent gut microbiomes.

Methods: Here, we utilized a non-human primate model of ethanol self-administration to characterize alcohol-induced alterations in gut microbes …

Optimized Nano-Bilosomes Loaded Ocular Insert As A Promising Approach For Boosting Voriconazole Ocular Bioavailability: In-Vitro, Microbiological, And In-Vivo Assessments, Eman Gomaa

Nanotechnology Research Centre

The eye possesses numerous physiological barriers that significantly limit the absorption of administered drugs, as only < 5 % get through. These barriers restrict drug bioavailability, often necessitating multiple dosing, which can lead to poor patient compliance. The study goal is to efficiently incorporate Voriconazole (VRC), a wide-spectrum antifungal candidate with a short half-life, into stable, biocompatible, non-irritating bile salt nanoparticles (Bilosomes, BLOs) to enhance its ocular delivery. Bilosomes were prepared by the ethanol injection method. Experimental (33) Box–Behnken Design (BBD) was employed; the amount of bile salt, cholesterol, and span-60 were chosen as independent variables, while entrapment efficiency (EE%), cumulative VRC release (Q8h), particle size (PS), zeta potential (ZP), and polydispersity index (PDI) were the dependent variables. The formula of optimization showed EE% (59.04 ± 1.88 %), cumulative release after 8 h (81.35 ± 0.69 %), PS (222.53 ± 2.04 nm), ZP (−72.53 ± 1.75 mV), and PDI (0.225 ± 0.03). It was chemically characterized using DSC and FTIR. Its spherical arrangement was confirmed using TEM. For ophthalmic application, the optimized formula was included in ocular inserts to extend ocular residence time while minimizing dosing frequency. The optimal VRC-loaded bilosomal ocular insert met the acceptable physicochemical criteria, was sterilized using UV radiation for conducting microbiological assay, in-vivo study, and pharmacokinetic analysis. For safety evaluation, an eye irritation study and histopathological examination were conducted. The results confirmed its effectiveness as evidenced by a significantly larger inhibition zone and 8.39-fold enhancement in VRC bioavailability compared to its suspension. These findings support the potential of bilosomes-loaded ocular insert as an effective ocular delivery of VRC.

Infantile Epileptic Spasms Syndrome: Clinical Profile And Outcomes At A Tertiary Hospital In Kenya, Peninah Mwangi, Katherine Oyieke, Sam Gwer, Pauline Samia

Paediatrics and Child Health, East Africa

Background: Infantile epileptic spasms syndrome (IESS) is characterised by onset of epileptic spasms between 3 and 12 months, with or without typical hypsarrhythmia, and developmental stagnation or regression. There are limited data on the clinical profile and treatment outcomes of IESS in sub-Saharan Africa.

Objective: To describe the clinical profile and treatment outcomes of infants diagnosed with and managed for IESS at Aga Khan University Hospital, Nairobi.

Methods: Records of children aged 3–24 months diagnosed with IESS between January 2012 and December 2021 were identified from the hospital information system using the terms “infantile spasm”, “epileptic spasms”, …

Beyond Fixed Thresholds: Per-Label Calibration For Fine-Grained Emotion Detection On The Goemotions Dataset, Sai Puneet Naga Venkata Subramanyam Patchipulusu

Selected Full-Text Master Theses 2021-

This study investigates the effectiveness of five community fine-tuned transformer models for fine-grained emotion detection on the GoEmotions dataset: SamLowe/roberta- base-go_emotions (RoBERTa-base), cirimus/modernbert-base-go-emotions (ModernBERT), mrm8488/deberta-v3-base-goemotions (DeBERTa-v3-base), bhadresh-savani/bert-base-go- emotion (BERT-base-cased),and tasinhoque/distilbert-go-emotions (DistilBERT) . While the original GoEmotions research by Demszky et al. (2020) established a BERT-base baseline with a macro-F1 of 0.46, this thesis extends that work through independent empirical evaluation of five derivative models, systematic per-label threshold optimization, and comparative analysis of architectural trade-offs across the full transformer model family. Using the GoEmotions simplified test split (5,427 examples across 28 categories), all five models were evaluated at a fixed 0.5 …

Establishing A Public Health Surveillance System For The Opioid Crisis: The Experience Of The Healing Communities Study, Bridget Freisthler, Daniel J. Feaster, Charles Knott, Marc Larochelle, John Mccarthy, Svetla Slavova, Sharon L. Walsh, Jennifer Villani

Biostatistics Faculty Publications

Introduction: Efforts to reduce opioid overdose deaths in the United States have been stymied by the lack of timely and standardized population-level data for local, state, and national levels. The U.S. has a strong national need for linking opioid and other drug overdose surveillance data to service utilization data for overdose prevention and treatment to inform resource allocation and response planning.

Methods: We provide insight on the challenges of identifying, obtaining, and harmonizing administrative outcome data across four states using the collective experience from the HEALing Communities Study to test a community-engaged, data-driven, population-level intervention to reduce opioid overdose deaths. …

Pediatric Clinical Reasoning Labs’ Impact On Student Self-Efficacy In Pediatric Physical Therapy Education, Bethany Early

Dissertations

All graduates of entry-level Doctor of Physical Therapy (DPT) programs must be competent to work with patients across the lifespan and high levels of perceived self-efficacy (SE) may be a predictor of future success. Experiential learning is an effective teaching and learning strategy used within Pediatric PT education (PedPTE). This study examined the extent to which pediatric clinical reasoning labs impact student SE within PedPTE, and to what extent does previous experience or interest in pediatrics have on perceived SE.

The methodology was a sequential explanatory mixed methods research design. Quantitative data collection included 27 second year DPT students, utilizing …

Enabling Communication Resiliency In The Connected Car Environment, Antonio Guerrero-Ibáñez, Juan Contreras-Castillo, Sherali Zeadally, Een-Kee Hong

Information Science Faculty Publications

Connectivity has become integral to various application domains, with the automotive sector as a prime example. Advances in electronics, computing, and telecommunications have driven the evolution of the connected car ecosystem, transforming it into a data-rich environment that enhances road safety, efficiency, and overall mobility. However, the success of this ecosystem depends on seamless, reliable, and resilient communications. We identify key challenges that may affect communications in the connected car environment and discuss solutions that enhance resiliency and robustness. Finally, we propose a multi-layered network architecture that will enhance communication resilience in the connected car ecosystem.

Curriculum In Pharmacoepidemiology Training Programs: A Cross-Sectional Study To Assess Educational Needs And Alignment With Core Competencies, Amie Goodin, Deborah Layton, Ryan Chung, Vicki Osborne, Chioma Ejekam, Xiaojuan Li, Xuerong Wen, Kristian B. Filion, Luciane Cruz Lopes, Daniela C. Moga

Pharmacy Practice and Science Faculty Publications

Purpose: Pharmacoepidemiology is a key discipline for evidence-based decision-making, yet its educational programs have not been systematically assessed for alignment with international core competencies. Our objectives were to evaluate curricula alignment of pharmacoepidemiology training programs with ISPE-recommended core competency themes and identify key curriculum content development areas.

Methods: The ISPE Core Competencies Workgroup and ISPE leadership developed a curriculum and needs assessment survey, incorporating feedback from global members. The survey was electronically distributed to leaders of pharmacoepidemiology training programs (e.g., department chairs and program directors) using the ISPE contact database, followed by snowball sampling to enhance representation. Institutional respondent characteristics …

Family Functioning And Stress In Arab American Young Adults, Sahar Kaouk

Selected Full-Text Dissertations 2020-

Family functioning plays a central role in the lives of Arab American young adults, yet little research has examined how family dynamics relate to stress in this population. Guided by Bowen’s (1978) Family Systems Theory, this study investigated the relationship between family functioning and perceived stress, as well as the roles of Differentiation of Self (DoS), Reflective Coping, and collectivistic orientation. Participants included 225 young adults ages 18 to 25 who self-identified as Arab American. Data were collected using self-report measures, and structural equation modeling was used to test the hypothesized model. Results indicated that family functioning was indirectly related …

Delivering Safe Sleep And Breastfeeding Education To Pregnant And New Mothers Through Private Facebook Groups: Study Protocol For A 4-Armed Randomized Controlled Trial, Rebecca F. Carlin, Margaret G. Parker, Ann L. Kellams, Fern R. Hauck, Stephen Kerr, Benjamin T. Cornwell, Marc T. Kiviniemi, Nicole Geller, Katherine E. Boguszewski, Michael J. Corwin, Eve R. Colson, Rachel Y. Moon

Health, Behavior & Society Faculty Publications

Background: Annually, more than 3500 US infants die suddenly and unexpectedly. Many sudden unexpected infant deaths (SUID) are preventable with greater adherence to safe infant sleep guidelines. There are racial and economic disparities in guideline adherence and SUID rates. Education alone has proven ineffective at altering behavior for many parents, and social networks and social norms regarding infant care have been found to influence rates of unsafe sleep. Using the power of social networks to shape social norms by delivering education through moderated online social media groups provides a unique opportunity to influence these practices in large groups of parents. …

Hyena Den Distribution, Human-Hyena Interactions And Mitigation Strategies In The Greater Amboseli Ecosystem, Katherine Elizabeth Davis Matczak

Honors Theses and Capstones

The Spotted Hyena (Crocuta crocuta) is a prevalent predator across Africa, recognized for their noticeable gait and powerful jaws which enable them to maul and scavenge on prey. Due to human population growth and encroachment onto wildlife territory, the overlap between human settlements and hyena den sites has become a growing concern, particularly regarding livestock predation. Livestock is intrinsic to livelihoods across Africa, with most individuals deriving their livelihoods from pastoralism. This paper provides an evaluation of den proximities to communities, hyena diet preference, human-hyena conflict/attitudes, and mitigation strategies used to protect hyenas, livestock, and the people. Results …

Mindfulness Matters: Reducing Anxiety In Prelicensure Undergraduate Nursing Students Using Virtual Reality Meditation Prior To High Fidelity Simulation., Lindsey K. Hildreth

Honors Theses and Capstones

Abstract:

The aim of this study was to evaluate the effectiveness of a 5-minute virtual reality (VR) meditation intervention in reducing self-reported anxiety among prelicensure nursing students immediately prior to their participation in a high-fidelity clinical simulation. Anxiety levels were measured using a Visual Analog Scale (VAS) and compared between students who participated in the VR meditation intervention and those in a control group receiving standard prebrief, and no VR meditation. It was hypothesized that students who engage in VR meditation would demonstrate a reduction in anxiety compared to students in the control group.

Current And Historical Occurrences Of Rare Coastal Plants In The Hampton Falls Salt Marshes, Liliana T. Chirichella

Honors Theses and Capstones

A botanical survey of two sites in the Hampton Falls saltmarshes was conducted to document the occurrences of a list of eleven endangered and threatened coastal plants listed in the Natural Heritage Bureau’s NH Rare Plant List. This survey was conducted in fulfillment of the NH Native Plant Protection Act to highlight and identify target species in an area where restorative runneling is to be implemented in order to restore proper hydrology and prevent further expansion of mega-pools in the Little River and Depot Road salt marsh sites, which have been subject to historical ditching and are a part of …

After The Impact: Balance Function In Women With Repeated Concussions, Caroline M. Stack

Honors Theses and Capstones

Balance deficits following repeated mild traumatic brain injuries are well documented, yet research examining the delayed outcomes specifically in college-aged women remains limited. The present study investigated whether women with a history of two or more mTBIs exhibit lasting balance impairments compared to women with zero or one prior mTBI, tested at least six months after their most recent injury. Thirty-four English-speaking women (ages 18-30) recruited from the University of New Hampshire were assigned to a repetitive mTBI group or a control group. Balance was assessed using the Balance Error Scoring System and a MetaMotion inertial measurement sensor positioned on …

Exploring The Association Between Internal Body Temperature And Metabolic Status In Early Lactation Jersey Cattle, Alexandra Ferreri, Claira Seely

Honors Theses and Capstones

No abstract provided.

Preserved Artificial Grammar Learning In Individuals With Parkinson’S Disease: A Systematic Review, Sarah I. Cranna

Honors Theses and Capstones

Abstract

            Implicit statistical learning is a crucial cognitive function that is highly involved in the learning and processing of language. Since both language and implicit statistical learning are supported by the basal ganglia through cortico-striatal networks, disruptions to this network could result in their impairment. Parkinson’s Disease (PD) can therefore be used to model disruptions to this system as it is primarily characterized by dysfunction in the basal ganglia. Thus, this review aims to examine the current literature studying the performance of individuals with PD on artificial grammar tasks in order to investigate the impact of impaired basal ganglia function …

An Intersectional Investigation Of Gendered Racial Microaggressions And Asian American Women’S Body Appreciation, Liujun Chen, Xiaoyin Liu, Thomas P. Le, Lydia H.R. Ahn

Psychology Faculty Research and Scholarship

While some research has explored the cultural correlates of negative body image among Asian American women, fewer studies have addressed what may contribute to body appreciation among Asian American women. We recruited a sample of 234 Asian American women via Prolific, who completed an online survey. Specifically, the present study examined (1) whether gendered racial microaggressions were associated with body appreciation among Asian American women, (2) whether resistance and empowerment against racism moderated this association, and (3) whether three subscales of internalized racism—self-negativity, weakness stereotypes, and appearance bias—mediated this association. A regression analysis showed a negative association between gendered racial …

The Impact Of Intimate Partner Violence On Victims’ Mental, Physical, And Economic Well-Being: A Comprehensive Literature Review (2012–2022), Kerry Lee, Jennifer L. Mezzapelle, Lyric N. Russo, Emily M. Douglas, Denise A. Hines

Graduate School of Social Work and Social Research Faculty Research and Scholarship

Intimate partner violence (IPV) remains a significant global public health concern, drawing increasing attention due to its profound impact on victims. A systematic review by Lawrence et al. (2012) demonstrated that IPV victims of physical and psychological abuse experience higher rates of physical injuries, poorer health outcomes, poorer physical functioning, and increased psychological symptoms compared to non-victimized individuals. Building on this work, we conducted a systematic review of 159 quantitative studies published between 2012 and 2022.

Across the included studies, more than half had samples ranging between 100-500 (52.8%, n=84) in size, were cross-sectional (84.9%; n=135), and utilized …

Shared Decision-Making And Coping During Fertility Treatments: Understanding Black Women’S Experiences Using A Reproductive Justice Lens, Lindsay Griffin

Bryn Mawr College Dissertations and Theses

Black women are up to twice as likely to experience infertility requiring fertility treatment to conceive, however Black women’s experiences of infertility and seeking medical treatment to become pregnant is sparsely represented in current empirical literature. Research on the topic of infertility and seeking fertility treatments has correlated infertility and fertility treatments with anxiety and depressive symptoms, but few studies have explicitly examined how Black women cope with these experiences. This dissertation study applied a Reproductive Justice lens to explore and understand 15 Black women’s experiences with seeking and receiving fertility treatments, experiences with shared decision-making for treatments to become …

Examining Structural Stigma In American Policy Making: A Case Study Of California Senate Bill 403, Anjali Bushan

Bryn Mawr College Dissertations and Theses

The South Asian American community is one of the fastest growing communities in the United States (Budiman & Ruiz, 2021). While research has explored various aspects of the South Asian American diaspora, limited research has focused on the caste system in the diaspora. This study examined caste on a macro level in American policy making. Using a qualitative case study design, it explored how the policy making process of California Senate Bill 403, a bill intended to prohibit caste discrimination, impacted structural stigma on caste and demonstrated interest convergence between caste supremacy and white supremacy in the United States. Findings …

Feasibility Of Brief Behavioral Telehealth Interventions For Sleep And Pain In Adults With Chronic Musculoskeletal Orofacial Pain: An Idiographic Clinical Trial, Linda Sangalli, Gabriel Gilmore, Isabel Moreno-Hay, Lauren N. Whitehurst, Anna Alessandri-Bonetti, Ian Andres Boggero

Oral Health Science Faculty Publications

Objective: Brief behavioral interventions targeting pain (Physical Self-Regulation, PSR) or sleep (Brief Behavioral Intervention for Insomnia, BBTI) show promise for interdisciplinary management of chronic pain, though their feasibility with chronic musculoskeletal orofacial pain (MSK-OFP) populations remains underexplored. This pilot study assessed the feasibility of a randomized clinical trial (RCT) of these interventions in a university-affiliated tertiary OFP clinic and explored clinical changes in pain, sleep, and other secondary outcomes.

Methods: Treatment-seeking participants (N=19) with chronic MSK-OFP and insomnia were randomized to three-session PSR or BBTI. At pre- and post-intervention, participants completed questionnaires (assessing pain intensity, insomnia symptomatology, sleep …

Expression Pattern Of The Hifα-Family In Equine Chorioallantois During Pregnancy And Placental Pathology, Yatta Boakari, Hossam El-Sheikh Ali, Gustavo Henrique Doná Rodrigues Almeida, Kirsten E. Scoggin, Claudia Barbosa Fernandes, Sophia Panelli Marchio, Mats H. T. Troedsson, Ana Claudia Oliveira Carreira

Maxwell H. Gluck Equine Research Center Faculty Publications

Equine placental dysfunction impairs fetal growth and disrupts pregnancy outcomes. Despite many advances in diagnosis, the molecular pathophysiology of equine placentitis and premature placental separation remains poorly understood. However, the hypoxia-inducible factor (HIF-α) pathway is related to placental hypoxia, and its modulation in placental diseases has been shown in other species. Therefore, we hypothesized that in conditions marked by equine placental dysfunction, oxygen deprivation in the chorioallantois membrane triggers the activation of the HIF-α pathway, which is related to molecular alterations associated with placental insufficiency. Accordingly, we compared the expression of HIF1A, HIF2A, HIF3A, and HIF1AN genes in equine chorioallantois …

Teaching Kitchen Safety Using A Modified Coach In The Kitchen Curriculum Paired With Behavioral Skills Training Procedure With Young Adults With High Functioning Autism, Ryan Michael Groeneweg

Dissertations and Theses

Few intervention studies address the needs of young adults with high‑functioning autism spectrum disorder (ASD) as they transition toward adulthood. This study used a single‑subject multiple‑baseline design across participants and skills to evaluate the effects of a modified Coach in the Kitchen curriculum paired with Behavioral Skills Training (BST) on the acquisition of kitchen safety behaviors. Three adults with high‑functioning autism were taught task‑analyzed steps for safe use of a kitchen peeler, knife, and hot liquids. Instruction incorporated modeling, rehearsal, feedback, prompting, and strategies for generalization and maintenance. Performance was measured as the percentage of safety steps correctly completed during …

Health Care Fraud And The End Of Chevron, Joan H. Krause

Faculty Publications

What do the Environmental Protection Agency’s “plantwide” definition of a “stationary” pollution source,” a National Marine Fisheries Service determination of who pays for fishing boat observers, and a Department of Health and Human Services rule governing the marketing of prescription drugs have in common? In short, a government agency’s interpretation of a federal statute. All three cases go to the heart of the administrative state: the ability of an agency, staffed by experts in the field, to interpret static statutory language to offer practical guidance to an ever-evolving industry.

The same is true of health care fraud, although it is …

From Rwanda To Montreal To Cedar Lake, Shane Niyonzima, Beverly Matiko

Lake Union Herald

No abstract provided.

Major Grant Received For Online School Psychology Program, Andrew Francis

Lake Union Herald

No abstract provided.