Digital Commons Network^™

Cross-Neutralization And Antigenic Characterization Of Simian And Equine Group A Rotaviruses, Shalini Soni, Lianne G. Eertink, Ni Shuisong, Alan T. Loynachan, Samantha M. Barnum, Emma Adam, Michael A. Kennedy, Dan Wang, Feng Li

Veterinary Science Faculty Publications

Rotaviral diarrhea in foals is caused by two dominant G3P[12] and G14P[12] genotypes of equine rotavirus A (ERVA). Protection of foals against ERVA infection and disease is achievable by passive antibody transfer through colostrum from mares receiving inactivated monovalent G3P[12] vaccine. Simian rotavirus SA11 G3P[2] is also included in ERVA vaccines to protect foals. Here, we characterized cross-neutralization and protection among three distinctive rotaviruses carrying the same or different G (defined by VP7) or P (defined by VP4) genotype by using a rabbit and equine monospecific antisera panel coupled with structural and computational analyses of viral epitopes. Data from these …

Dark And Camouflaged Genomic Regions Remain Challenging In Chm13, Mark E. Wadsworth, Madeline L. Page, Bernardo Aguzzoli Heberle, Justin B. Miller, Cody J. Steely, Mark T. W. Ebbert

Sanders-Brown Center on Aging Faculty Publications

Comprehensive genomic analysis is essential for advancing our understanding of human genetics and disease. However, short-read sequencing technologies are inherently limited in their ability to resolve highly repetitive, structurally complex, and low-mappability genomic regions, previously coined as “dark” regions. Long-read sequencing technologies, such as PacBio and Oxford Nanopore Technologies (ONT), offer improved resolution of these regions, yet they are not perfect. With the advent of the new Telomere-to-Telomere (T2T) CHM13 reference genome, exploring its effect on dark regions is prudent. In this study, we systematically analyze dark regions across four human genome references—HG19, HG38 (with and without alternate contigs), and …

Toward A Predictive Model Of Success In Contingency Management: A Proof Of Concept Study Utilizing Behavioral Economic, Clinical Severity, And Alcohol Use Severity Measures, Haily K. Traxler, Christopher T. Franck, Mikhail N. Koffarnus

Behavioral Science Faculty Publications

As contingency management (CM) moves from research to practice, researchers have a responsibility to outline the minimum procedural necessities that lead to an effective, sustainable treatment that can be implemented as a mainstream therapy for substance use disorders. To begin identifying the minimum requirements, the purpose of the current study was to provide framework and a first step toward building a risk calculator that predicts treatment outcomes in CM, and can predict the optimal incentive size to prescribe by evaluating behavioral economic factors, demographic variables, and use severity measures in individuals who completed CM treatment for alcohol use. Participants were …

Strengthening Rural Health Care: A Scoping Review Of Nurse Recruitment And Retention Strategies, Kelley Arredondo, Laura Witte, Alexander Paterson-Roberts, Alexandra Caloudas, Matthew Vincenti, Bradley V Watts, Bronwyn Sutherland, Hilary Touchett

Library Staff Publications

Background: Despite nursing being the largest US health profession, only 16% of registered nurses (RNs) practice in rural areas, where health care access is limited. This significantly impacts rural residents, including over 2.7 million rural veterans receiving care at the Veterans Health Administration, leading to compromised health outcomes. Nurses are vital in primary care, improving coordination and management of chronic conditions.

Objectives: Identify recruitment and retention programs for rural nurses (licensed vocational nurses/licensed practical nurses and RNs), including strategy characteristics and location.

Research design: We conducted a scoping review of published and gray literature. Eligible studies targeted US rural nurse …

From The Desk Of The Editors: Dr. Alex Garcia-Putnam And Amelia Sethi (Student Co-Editor), Alex Garcia-Putnam, Amelia Sethi

Spectrum

No abstract provided.

Decreasing The Prevalence Of Hiv/Aids Misinformation And Stigma In South Africa, Matt Jasper

Spectrum

Misinformation about HIV/AIDS, an insidious disease spread by contact with infected blood, semen, vaginal fluid, or breast milk, persists in South Africa, a long-time epicenter for the pandemic. One of the largest contributors to the continuation and social harm associated with this disease is stigma. In a study that examined stigma towards HIV/AIDS in South Africa using surveys, 76% of people stated that people living with HIV (PLWHIV) experience stigma and are treated differently. Along with this, 45% of people reported that they were uncomfortable being around PLWHIV, and among those that have the disease, 73% believe that disclosing their …

How Racial Discrimination Accelerates Biological Aging, Leah Maddison

Spectrum

No abstract provided.

Does Neanderthal Dna Impact Modern Behavioral And Psychological Traits, Kiernan Werchniak

Spectrum

No abstract provided.

Physical Health Impacts Of Increased Digital Technology Use, James Poupolo

Spectrum

No abstract provided.

Poverty And Health: Skeletal Evidence Of Syphilis At Charity Hospital Cemetery #2, New Orleans, Louisiana (1842-1929), Connor Lincoln

Spectrum

No abstract provided.

Fostering Student Joy And Motivation For Reading, Meghann Mcdonald

Master of Education in Transformational Teaching and Learning

Noting the decline in students’ access to school library spaces, along with growing educator discourse surrounding declining youth reading enjoyment, the critical question emerged: What classroom strategies increase students’ motivation and enjoyment of reading? This classroom inquiry took place in a sixth-grade Humanities classroom of 21 students at a small Catholic school in North Seattle. Drawing from research surrounding aesthetic reading, reader identity, student agency, and reading community, the study investigated how an independent reading routine, student choice in text selection, and peer interactions around reading influenced students’ motivation and enjoyment of reading. Data was collected over a three-week period …

The Joy Of Reading: An Action Research Project, William Cronin

Master of Education in Transformational Teaching and Learning

This study is to investigate what impact sustained silent reading in class will have on student enjoyment in reading. The study was conducted over a two-week period in which students were given 10-15 minutes for sustained silent reading of a hard-copy book of their choice at the end of each class meeting. They were then asked in a survey how they felt after reading, and to give a reason why they answered in that way. Students were also surveyed at the beginning and end of the study with a series of questions about their reading habits and enjoyment level. The …

Antimicrobial Activity Of Violacein Extracted ​ From Janthinobacterium Lividum​, Catherine M. Brownhill-Slatore

Scripps Senior Theses

Abstract

Antibiotic-resistant bacteria have been a threat since the discovery of antibiotics. The increased rise of antibiotic-resistant bacteria has created an immediate need for new antibiotics. Violacein, a purple bisindole pigment produced by Janthinobacterium lividum, has been shown to be a promising new antibiotic. Its efficacy has not been completely demonstrated, and this project aims to further investigate the effectiveness of violacein as an antibiotic. To do this, a minimum inhibitory concentration (MIC) test was conducted. Violacein was grown, extracted, purified, and tested across concentrations ranging from 1.0 to 500.00 µg/mL to cover values well above and below previously cited …

Data-Driven Thresholds For Standardized Classification Of Severe Alzheimer’S Disease Neuropathology Using Digital Neuropathology, Ryan K. Shahidehpour, Allison M. Neltner, Mitchell A. Klusty, Cole Corbett, Angelique D. Gonzalez, David A. Gutman, David W. Fardo, Adam D. Bachstetter, Cody Bumgardner, Margaret E. Flanagan, Peter T. Nelson

Sanders-Brown Center on Aging Faculty Publications

Alzheimer's disease neuropathological changes (ADNC)—operationalized with semi-quantitative parameters—represent the consensus-based gold standard for diagnostic evaluation of disease severity. Although useful, ADNC diagnostic frameworks have limitations, particularly in advanced disease stages where pathological severity varies widely within a given diagnostic category. Further, some individuals lacking cognitive impairment are inappropriately categorized as having severe ADNC. In this study, quantitative pathology metrics and alternative tissue sampling schemes were integrated with data about premortem cognitive status, in order to derive clinically informed neuropathologic diagnostic thresholds. Specific goals of the current study were to generate data-driven, standardized diagnostic cut-points, with the most severe stages of …

Clonal Expansion Of Cytotoxic Cd8⁺ T Cells In Lecanemab-Associated Aria, Lance A. Johnson, Kai Saito, Akhil V. Pallerla, Jessica L. Funnell, Ashley R. Ezzo, Chelsea M. Song, Douglas A. Harrison, Noah J. Norton, Lauren C. Moore, Linda J. Van Eldik, David W. Fardo, Greg E. Cooper, Josh M. Morganti

Sanders-Brown Center on Aging Faculty Publications

Amyloid-related imaging abnormalities (ARIA) are the principal safety concern limiting anti-amyloid therapies for Alzheimer’s disease, yet their biology remains unclear. Here we show, through multi-omic profiling of peripheral blood from three ARIA+ patients and matched controls, that ARIA is associated with coordinated reprogramming of CD8 + T cells. CD8+ effector memory (TEM) and terminally differentiated (TEMRA) subsets were expanded, clonally enriched, and transcriptionally primed for cytotoxicity and vascular trafficking. Transcription factor inference and metabolomics converged on glycolytic reprogramming favoring short-lived effector function. Ligand-receptor modeling revealed enhanced monocyte-to-T cell signaling through antigen presentation, adhesion, and chemokine axes, while integration with a …

Developing A Community-Driven, Locally Sourced Medically Tailored Meal Model: A Pilot Linking Healthcare, Farmers, And Patients, Julie Brown, Ashton Potter, Leandra Forman, Jairus J. Rossi, Anna Cason, Christa Mayfield, Alison Gustafson

Dietetics and Human Nutrition Faculty Publications

Background: Food is Medicine (FIM) programs improve health outcomes by integrating nutrition interventions into healthcare delivery, yet gaps remain in community partner capacity and local food system integration. This program aimed to build community capacity to develop a locally sourced, medically tailored meal (MTM) model connecting farmers, healthcare providers, and patients. Methods: Meals were developed by a registered dietitian following American Heart Association (AHA) Heart-Check and MyPlate nutrition standards. Recipes were adapted for freezing, scaled for production, and sourced from 26 central Kentucky farms. Eligible participants with hypertension or type 2 diabetes (T2D) were referred through the Food as Health …

Library Advisory Council 2025-2026 End Of Academic Year Report, Central Washington University

Library Advisory Council for CWU Libraries

Library Advisory Council 

2025-2026 

End of Academic Year Report 

Infringement Through Imitation: Ai Chatbots And The Characters They Infringe, Isabella Herrera

Fordham Intellectual Property, Media and Entertainment Law Journal

Chatbots that purport to embody the personas of copyrighted characters are poised to be a central issue for the IP legal field and the entertainment industry. In September of 2025, Disney sent a cease-and-desist letter to Character.AI, a leader in the “character” chatbots market, demanding removal of numerous chatbots that were reportedly based on characters from Disney franchises like Star Wars, Marvel, and the Pixar films. Character.AI allegedly removed all infringing characters, however it remains unclear whether character chatbots platforms are required to do so under IP law. This Note addresses the issue of copyright infringement for character chatbots and …

Knowledge Based Automated Planning For Non-Coplanar Vmat Stereotactic Radiosurgery In Ocular Malignancies, Chase Cochran, Shane Mccarthy, William St. Clair, Damodar Pokhrel

Radiation Medicine Faculty Publications

Background and Purpose: Stereotactic radiosurgery/radiotherapy (SRS/SRT) has emerged as a less invasive alternative to enucleation in the management of ocular malignancies. SRS/SRT planning is time-consuming, complex, and the plan quality depends on the experience of the treatment planner. We demonstrate the use of RapidPlan modeling in conjunction with HyperArc for the treatment of ocular diseases to improve planning efficiency, consistency, and quality.

Materials and Methods: A HyperArc-based RapidPlan (HARP) model was iteratively trained on 80 patient datasets that simulated ocular malignancies. Twenty additional patient datasets were reserved for model testing and comparison with manual plans. Each testing dataset was both …

Designing Theranostic Radiopharmaceutical Trials For Uterine Cervix Cancer, Denise Fabian, Molly E. Buffington, Brianna S. Cagle, Steve M. Keefe, Michael K. Schultz, Charles A. Kunos

Radiation Medicine Faculty Publications

Designing and interpreting early phase trials of theranostic radiopharmaceuticals remains challenging because it is difficult to isolate effective levels of activity in enriched patient populations that would be worth following up in later-phase development. This study explores the known challenges and emerging opportunities for clinical research on patients with uterine cervical cancer. We identified eight randomized combination trials for advanced-stage uterine cervix cancer that were activated between 2011 and 2022 and tabulated their results to determine whether combinations were better than individual constituents and which suitable study population is best situated for the study of a new theranostic agent. In …

Broadening The Fetal Alcohol Paradigm: Bdnf Methylation As A Link Between Paternal Alcohol Use And Offspring Neurodevelopmental Deficits, Caitlin E. Muñoz

Scripps Senior Theses

Developmental effects of fetal alcohol exposure are extensively documented as a consequence of maternal gestational alcohol consumption. However, similar consequences of paternal alcohol consumption remain understudied. This proposed pilot study will examine preconception paternal alcohol consumption within its capacity to induce heritable epigenetic modifications in sperm, such that offspring are susceptible to adverse in utero neurodevelopment and neonatal neurobehavioral outcomes. Specifically, it will examine DNA methylation patterns along the brain-derived neurotrophic factor (BDNF) exon IV promoter in paternal spermatozoa. BDNF exon IV is considered a key locus in neurogenesis regulation, synaptic plasticity, and cortical development. It is hypothesized that BDNF …

Ghostwriting The Government, Bridget C.E. Dooling

Marquette Law Review

Ghostwriting is when a writer prepares materials to be issued under someone else’s name. The word describes a politician’s use of a speechwriter, a student’s purchase of a term paper, or a tongue-twisted admirer asking a poet to craft a love letter on his behalf. It also happens inside organizations every day: staff draft documents for others “up the chain” to sign. But when legislators rely on staff and lobbyists to draft bills, when an agency head relies on staff or contractors to write a rule, and when a judge relies on her clerk for a draft opinion, the benefits …

Public Rights, Democracy, And The Separation Of Powers, James L. Huffman

Marquette Law Review

This Article examines the concept of public rights in the contexts of democratic governance and the constitutional separation of powers. While the concept of public rights has a long history in Anglo-American law, over the last several decades, the term is often employed with only vague reference to its historic meanings and with little or no definition. With reliance on the centrality of the concept of rights in American constitutional government, it is commonly claimed that public rights, like private rights, can be enforced in the courts as constraints on legislative and executive actions.

In American caselaw public rights have …

Narrating Institutional Becoming: Faith, Leadership, And Identity Reconstruction During A College-To-University Transition, Viviene H. Dyer

Dissertations

Problem

The contributions of faith-based higher education institutions to the tertiary landscape in small island developing states are insufficiently addressed in the scholarly literature. Consequently, there is limited understanding of how these institutions navigate organizational transitions and respond to capacity gaps that the public sector is unable to fill within dynamic cultural and regulatory environments. This gap is especially evident for Seventh-day Adventist institutions, whose efforts to preserve mission and identity during periods of institutional change remain underexamined and poorly documented.

Purpose

The purpose of this narrative inquiry study was to examine how university administrators influenced the development and ongoing …

A Qualitative Multiple Case Study Exploring Shifts In Thinking Of Principals Through Initiatives To Foster Relational Leadership Conducive To Retaining Teachers In High-Minority, High-Poverty Public Schools, Rita Seay

Dissertations

Problem

The public education system is broken, and teacher shortages have reached a crisis, especially in some specialty fields in United States (Carrillo & Salhotra, 2022; Podolsky et al., 2016). Lately, the teacher workforce has been described as a “leaky bucket” (Podolsky et al., 2016, p. 1). Indeed, the problems are complex in poor socioeconomic communities with racial and ethnic groups of students because teachers struggle to make a difference and, in most cases, fail due to insurmountable situations that are beyond their scope of influence (Rondfeldt et al., 2013). Evidence published that students suffer immensely from a broken, segregated …

Collegial Support As A Key Component Of Beginning Special Education Teacher Retention, Olivia A. Brammer

All Electronic Theses and Dissertations

This thesis reviews current studies to examine how collegial support is a key component of beginning special education teacher retention through classroom and instructional support, observations and coaching, and emotional and mental health support. The literature shows that across rural and urban school districts in the United States, colleagues and their support play an important role in the retention of beginning special education teachers. The thesis also points to the need for further research on mentorship and induction programs for beginning special education teachers as they navigate their unique roles. While the results show the impact of collegial support on …

Finding Meaning And Value In Old Age, Jane Nell Morgan

All Electronic Theses and Dissertations

This project addressed finding meaning and value in old age. The research conducted explored barriers to achieving meaning and value and how to overcome those obstacles. The research specifically focused on senior adults who reside in a Christian-based assisted living home located in the Twin Cities, Minnesota. In response to this problem, the researcher studied the lives of three older biblical characters, Jacob, the author of Psalm 71, and Anna, and reviewed relevant literature on barriers senior citizens face today. In addition, research included the damaging effects older adults face when they fail to find meaning in their lives and …

The Presence Of Predators Moderates Evolutionary Responses Of Trinidadian Killifish To A Novel Parasite, Anne E. Christian

Biology Dissertations

The Healthy Herds Hypothesis suggests the idea that prey populations derive a benefit from their predators: predators reduce the exposure of their prey to infectious disease, both by limiting prey population densities and by eliminating sick individuals. Much research has focused on the balancing effect that predators have on ecosystems. There is a current need for research into whether these effects cause evolutionary shifts in prey populations, where strong predation pressure prevents prey species from evolving physiological tolerance or resistance to infectious agents. Parasites especially often have rapid effects on host evolution, due to exploitative interactions.

I seek to address …

Hosts, Scouts, And Female Indentured Sexual Servitude In Contemporary Japan, Caroline Norma, Seiya Morita

Dignity: A Journal of Analysis of Exploitation and Violence

This article sweeps away glossy abstractions obscuring the indenturing of women in sexual servitude in Japan. These abstractions were generated by anthropologists writing in English in the first two decades of the 21^st century who inverted the relationship between perpetrator and victim to suggest that female customers exploited hosts. To overturn this view and expose the ‘gendered reality that [i]s really going on’ in Japan, this article differently explains from a feminist perspective how present-day host and scout businesses indenture Japanese women in sexual servitude. This role is one of both procuring victims as well as keeping young women …

Implementation Of A Turn Team To Reduce Hospital-Acquired Pressure Injuries In A Medical Intensive Care Unit, Heather A, Adair

Doctor of Nursing Practice Final Project Abstract

Implementation of a Turn Team to Reduce Hospital-Acquired Pressure Injuries in a Medical Intensive Care Unit

PURPOSE

The project aimed to reduce hospital-acquired pressure injury (HAPI) rates in a Medical Intensive Care Unit (MICU) by improving nurses' knowledge of the Braden Scale and implementing a structured two-nurse turn team workflow to reposition high-risk patients every two hours.

RESULTS

Repositioning compliance improved substantially and consistently exceeded the project goal of 90% after implementing a pod-based workflow. The HAPI prevalence rate decreased from a baseline of 8% to below the project goal of ≤5% during implementation but was not sustained in the …