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The Impact Of Awareness Of Campus Health Services On Utilization Of Medical Care Among Residential Students At Liberty University, Catherine Pandagade Jan 2026

The Impact Of Awareness Of Campus Health Services On Utilization Of Medical Care Among Residential Students At Liberty University, Catherine Pandagade

Masters Theses

College students represent the most prominent group of individuals when considering their lifestyles throughout aging. Therefore, this age group serves as a good opportunity for health education that could build positive health behaviors for life. Existing literature have said that the 18-25 year olds tend to have fewer resources and be often uninsured and have the highest rates of preventable diseases.2 Objective: The aim of this research is to investigate the impact of awareness and its subsequent effect on utilization of available health resources on campus among the student population of Liberty University. Additionally, the purpose of the research through …


Estimation Of The Reliability Function Of The Maxwell - Boltzmann Distribution Using The M-Robust Estimation Methods And Comparing Them With Conventional Methods, Shaymaa Riyadh Thanoon Jan 2026

Estimation Of The Reliability Function Of The Maxwell - Boltzmann Distribution Using The M-Robust Estimation Methods And Comparing Them With Conventional Methods, Shaymaa Riyadh Thanoon

Baghdad Science Journal

To achieve the best possible outcomes. The reliability function estimation was also established for the In this study, the scal parameter Maxwell distribution was estimated using both traditional and robust methods, and the results were compared typical estimation methods, which included the Maximum Likelihood method (MLE), the moments method (MOM), and the M- robust method The results were compared using the mean error squared (MSE). The M-robust technique was found to have the lowest mean square error across all sample sizes, as demonstrated by the findings hence, it is regarded as being more effective than the conventional estimate methods. In …


Robust Qr Code Counterfeit Detection By Integrating Vgg19 Neural Embedding And Triplet Loss, Gede Putra Kusuma, Yulianto Yulianto, Renaldy Fredyan, Hendi Chandi, Jeffry William Tan, Philip Kwan, Muhammad Dafa Syukur Jan 2026

Robust Qr Code Counterfeit Detection By Integrating Vgg19 Neural Embedding And Triplet Loss, Gede Putra Kusuma, Yulianto Yulianto, Renaldy Fredyan, Hendi Chandi, Jeffry William Tan, Philip Kwan, Muhammad Dafa Syukur

Baghdad Science Journal

Detecting counterfeit Quick Response codes plays a critical role in protecting the integrity of products and documents. This paper presents a novel methodology to increase the reliability of QR code counterfeit detection by integrating neural embedding VGG19 and triplet loss. The approach uses deep neural networks. Specifically, the modification of the VGG19 architecture is used to extract unique features from QR codes. These features are embedded in a multi-dimensional space using neural embedding methods. The use of the triplet loss function aims to increase the discriminative power of the embeddings, ensuring the discriminative power of the embeddings, and ensuring that …


From Retaliation To Restoration: Evaluating Norwegian Prison Rehabilitation Models For United States Integration, Lucas I. Abbott Jan 2026

From Retaliation To Restoration: Evaluating Norwegian Prison Rehabilitation Models For United States Integration, Lucas I. Abbott

Doctoral Dissertations and Projects

This study evaluates the viability of implementing Norwegian rehabilitative frameworks within the American prison system by gathering the perspectives of formerly incarcerated men in the United States. Using a qualitative phenomenological design, the research sought to understand how American offenders perceive Norwegian normalization techniques, such as single-occupancy rooms, humane architectural environments, respectful inmate-officer relationships, and their potential to promote rehabilitation and reduce recidivism. Fifteen participants who had served a minimum of three weeks in correctional institutions completed open-ended questionnaires analyzed through conceptual content analysis. Findings revealed strong support for individualized rooms, normalized environments, and increased positive human interaction as transformative …


Vocal Strain In General Music Educators: Choral Vs. Instrumental Training, Jennifer Mclean Stadelmeyer Jan 2026

Vocal Strain In General Music Educators: Choral Vs. Instrumental Training, Jennifer Mclean Stadelmeyer

Doctoral Dissertations and Projects

Elementary general music educators are at high risk for vocal strain due to the continuous demands of speaking, singing, and classroom management throughout the school day. Prolonged vocal strain can result in voice loss, vocal cord damage, and hoarseness. While the issue of vocal health in educators is widely acknowledged, limited research examined the specific factors contributing to vocal strain among general music educators, particularly in relation to their training backgrounds. This quantitative, causal-comparative study investigated the difference in vocal strain between choral-trained and instrumental-trained music educators teaching elementary general music. Participants included elementary general music educators (N = 12) …


Examining The Psychological Impact Of Adverse Childhood Traumatic Experiences In Adult Survivors: Creating A Community Of Awareness And Intervention, Lawanda T. Mobbs Jan 2026

Examining The Psychological Impact Of Adverse Childhood Traumatic Experiences In Adult Survivors: Creating A Community Of Awareness And Intervention, Lawanda T. Mobbs

Doctoral Dissertations and Projects

Childhood trauma encompasses experiences such as abuse, neglect, and household dysfunction, experiences which have profound and lasting effects on an individual’s development and well-being. These behaviors can manifest in many ways. The intricate interplay between childhood trauma, mental health challenges, and maladaptive behaviors creates a complex clinical picture, often requiring specialized and trauma-informed approaches within the community. Understanding the efficacy of interventions tailored to this population is crucial for improving the quality of life and fostering resilience. Despite extensive research, there remain significant gaps in understanding the full scope of these effects and how to mitigate them. This study investigated …


African American Adult Male Survivors Of Childhood Sexual Abuse And Their Subsequent Experiences In Intimate Partner Relationships, Christian Lee Jefferson Jan 2026

African American Adult Male Survivors Of Childhood Sexual Abuse And Their Subsequent Experiences In Intimate Partner Relationships, Christian Lee Jefferson

Doctoral Dissertations and Projects

The purpose of this qualitative interpretive phenomenology study is to explore the lived experiences of African American adult male survivors of childhood sexual abuse within intimate partner relationships. The problem is that it is not known how African American adult male survivors of childhood sexual abuse describe their present or past intimate partner relationships experience or the impact that childhood sexual abuse has on their intimate partner relationships. Research shows how experiences of sexual abuse create difficulty in managing intimate partner relationships. Many survivors of childhood sexual abuse often had damaging effects on adults with their romantic relationships. Findings from …


The Relationship Between The Health Science Reasoning Test And Successful Completion Of An Associate Degree Nursing Program: A Retrospective Predictive Study, Joyce A.Ajkuce Kucerovy Jan 2026

The Relationship Between The Health Science Reasoning Test And Successful Completion Of An Associate Degree Nursing Program: A Retrospective Predictive Study, Joyce A.Ajkuce Kucerovy

Doctoral Dissertations and Projects

The purpose of this study was to retrospectively identify whether the addition of an entrance exam such as the Health Science Reasoning Test (HSRT) to the current admission criteria of an associate degree nursing (ADN) education program would aid in selecting students with the highest chance of successfully completing the program and entering the workforce. A nonexperimental, retrospective, quantitative, predictive correlational study design was used. A retrospective convenience sample of 320 first-year nursing students in an ADN education program was obtained. The G* power analysis showed a minimum sample size of 107 students was needed. Statistical analysis involved a multiple …


Investigating The Reliability And Validity Of The Social Connectedness Instrument Among U.S. Adults, Blake A. Fraser Jan 2026

Investigating The Reliability And Validity Of The Social Connectedness Instrument Among U.S. Adults, Blake A. Fraser

Doctoral Dissertations and Projects

Growing evidence shows that poor social connectedness is becoming a public health threat, with rising prevalence and connections to poor mental and physical health across the lifespan. Therefore, there is an urgent need to develop feasible and effective social connectedness interventions. There is limited evidence for the effectiveness of current interventions, with studies recommending tailoring the intervention to an individual’s specific social connection needs. However, previous measures of social connectedness provide little information about potentially modifiable contributors of poor connection. Thus, the Social Connectedness Instrument (SCI) was developed to fill in this gap by proposing two novel latent constructs of …


Racial Bias, Mindfulness, And Motivation Among Mental Health Clinicians, Deirdre Y. Burton Jan 2026

Racial Bias, Mindfulness, And Motivation Among Mental Health Clinicians, Deirdre Y. Burton

Doctoral Dissertations and Projects

Racial bias is linked to poor mental health outcomes and obstructs clinician-client relationships. Mental health clinicians (MHCs) may express implicit bias, expanding disparities for people of color. Mindfulness and motivation to respond without prejudice (MRP) are associated with reduced racial bias, yet few studies have examined these constructs among MHCs. Therefore, the purpose of the study was to evaluate relationships between mindfulness, MRP, and implicit racial bias. Licensed MHCs (n = 47, 85.1% female, 59.6% African American, mean age 50 years) participated in a convergent parallel mixed-methods study involving an online survey [Race Implicit Association Test (Race IAT), the Five …


A Phenomenological Study Of The Personal And Professional Experiences Of U.S. Police Leaders Who Led Their Agency Through A Line-Of-Duty Death, Elizabeth A. Cary Jan 2026

A Phenomenological Study Of The Personal And Professional Experiences Of U.S. Police Leaders Who Led Their Agency Through A Line-Of-Duty Death, Elizabeth A. Cary

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to describe the personal and professional experiences of police leaders from across the United States who led their agencies through line-of-duty deaths (LODD). The social constructivist worldview guided this study as Creswell and Poth (2025) suggest that it captures complicated and multifaceted subjective meanings of individuals. Transformational leadership theory was the lens through which this research was conducted. Police leaders are faced with personnel, political, societal, and generational challenges following the events of Ferguson, George Floyd, the COVID-19 pandemic. This is on top of the already stressful and traumatic work police officers face …


Resiliency Among Service Industry Workers: A Biopsychosocial-Spiritual Assessment, Winston King Jan 2026

Resiliency Among Service Industry Workers: A Biopsychosocial-Spiritual Assessment, Winston King

Doctoral Dissertations and Projects

The purpose of this study was to quantify service industry workers’ resiliency’s relationships with their emotional intelligence, understanding of differing personality types, spiritual resiliency, and substance abuse, as these are all applicable to the biopsychosocial-spiritual model, which served as the theoretical framework. The study included administering the Brief Resilience Scale (BRS), the Schutte Self-Report Emotional Intelligence Test (SEIT), a self-reporting of employees’ understanding of differing personality types, a self-reporting of employees’ spiritual resiliency, and the Substance Use Brief Screen (SUBS) to social science graduate students working in the service industry. Resiliency was identified as the predictor variable and the other …


A Qualitative Exploration Of Global Remote Leadership, Melissa Morrison Jan 2026

A Qualitative Exploration Of Global Remote Leadership, Melissa Morrison

Doctoral Dissertations and Projects

Leaders of organizations have faced many changes with respect to remote work. As face-to-face interactions decrease, the opportunities and challenges of technological and digital advancement further the complexity of remote work. Leaders serve as prominent figures who use remote technology to communicate and interact with employees that report to them. The relationship between remote work and the development of meaningful social interactions remains largely unexplored (Clark et al., 2018). This phenomenological study explored the described experiences of remote leaders, the role that identity development plays in the success of leadership remote work, how their identity development impacts their well-being and …


Evaluation Of Handgrip Strength As A Surrogate Measure For Athletic Performance Metrics And Lower-Body Strength In High School Boys Basketball Players, Joseph R. Northcutt Jan 2026

Evaluation Of Handgrip Strength As A Surrogate Measure For Athletic Performance Metrics And Lower-Body Strength In High School Boys Basketball Players, Joseph R. Northcutt

Doctoral Dissertations and Projects

This quantitative correlational study examined relationships between bilateral handgrip strength (HGS) and athletic performance metrics, including vertical jump height, barbell squat one-repetition maximum (1RM), sprint speed, agility, and upper-body muscular endurance (push-up repetitions), in adolescent male basketball players. The study also evaluated whether inter-limb strength asymmetry was associated with the athletic performance outcomes.

29 male athletes aged 14-18 years participated in the research that included handgrip strength, vertical jump, lane agility drill, shuttle run, ¾-court sprint, push-up repetitions, and 1RM barbell squat. Statistical analyses were conducted using Jeffreys’s Amazing Statistics Program (JASP) and included Pearson product-moment correlations, Shapiro-Wilk assumption testing, …


Prevalence Of Intimacy Satisfaction In Relation To Burnout And Trauma Saturation Of First Responders, Krystoffer L. Bowman Jan 2026

Prevalence Of Intimacy Satisfaction In Relation To Burnout And Trauma Saturation Of First Responders, Krystoffer L. Bowman

Doctoral Dissertations and Projects

A shared understanding of this issue enables us to recognize the uniqueness of each individual’s experience, supported by the consistent commitment of trauma-saturated professionals. But what happens when these individuals become so accustomed to trauma that they can no longer recognize it as such? When their professional identity is inherently tied to continuous exposure to trauma, they may unconsciously adopt emotional distancing as a coping mechanism, which can appear to others as a fixed personality trait or lifestyle, even outside the workplace. This professional emotional distancing, often a consequence of growing burnout and trauma saturation, may negatively impact intimacy satisfaction. …


Evaluating Theories On End-Of-Life Dreams And Visions With Similar Phenomena In Trauma-Related Populations, Christopher Channy Vinson Jan 2026

Evaluating Theories On End-Of-Life Dreams And Visions With Similar Phenomena In Trauma-Related Populations, Christopher Channy Vinson

Doctoral Dissertations and Projects

A grounded theory approach was used to conduct a study on participants (N=24) who were veterans with trauma-related dreams or who had a near-death experience. Research questions were designed to qualitatively examine the lived experiences of dreams and visions in a non-end-of-life setting. This allowed the data to give greater insight into the end-of-life phenomenon and deepen the body of knowledge on dreams and visions in general. A survey consisting of the PTGI-SF, LuCiD, NExS, and the Greyson NDE, along with open-ended survey questions designed to record dream narratives for a thematic analysis, was used. The dream narratives were coded …


Officers On Patrol: Perspectives Of An Arrest On Past And Present Law Enforcement Officers, Shanee N. Ellington Jan 2026

Officers On Patrol: Perspectives Of An Arrest On Past And Present Law Enforcement Officers, Shanee N. Ellington

Doctoral Dissertations and Projects

While attempting to apprehend suspects, police officers must contend with complex obstacles arising from the arrest's legal, ethical, and sociopolitical context. Officers had to follow their department’s guidelines while also developing legal procedures when carrying out an arrest. The study focused on how an officer’s perception of arrest decisions and procedures encapsulated challenges and ethical dilemmas. Through a semi-structured interview with twenty respondents, this research explored the implications of arresting behaviors on officers’ professional identity formation and development. The data analysis followed the grounded theory approach, which focused on identifying differences and similarities between former and current officers over time. …


Examining The Intergenerational And Transgenerational Impact Of Military-Related Posttraumatic Stress Disorder On Academic Success In College Students In The United States, Kimberlee Bazo Jan 2026

Examining The Intergenerational And Transgenerational Impact Of Military-Related Posttraumatic Stress Disorder On Academic Success In College Students In The United States, Kimberlee Bazo

Doctoral Dissertations and Projects

Military families and caregivers have unique experiences with their service member which can both enhance and challenge their daily lives. The purpose of this dissertation was to examine the transgenerational and intergenerational impact of military-related posttraumatic stress disorder (PTSD) on academic success in college students in the United States. This non-experimental, quantitative research design utilized both descriptive and correlational data analysis. Self-report measures and grade point average (GPA) provided the data from a total of 67 participants, as determined by an a priori analysis, for the results and subsequent discussion sections. Participants were recruited through a variety of sources using …


Exploring The Counselor Identities Of Latina Counselors Through The Lens Of Their Familial, Cultural, And Religious Contexts: A Phenomenological Study, Samuel Landa Jan 2026

Exploring The Counselor Identities Of Latina Counselors Through The Lens Of Their Familial, Cultural, And Religious Contexts: A Phenomenological Study, Samuel Landa

Doctoral Dissertations and Projects

Developing a counselor identity is an essential component of becoming a counselor. There are several factors influencing the developmental process. Though there are several studies that explore the topic of counselor identity development, the research on what this process entails for Latina counselors is limited. Thus, this transcendental phenomenological qualitative study explores how family, culture, and religion influence the counselor identity development of Latina counselors. This study utilized Schlossberg’s transition theory (1981) to observe how these factors become evident in the first year of their Council for Accreditation of Counseling and Related Educational Program (CACREP) and how they influenced their …


Examining Perceived Problem-Solving Skills, Parenting Styles, And Biblical Principles: Insights From Parents Or Guardians Of African American Teen Males, Dorothy Farrow Jan 2026

Examining Perceived Problem-Solving Skills, Parenting Styles, And Biblical Principles: Insights From Parents Or Guardians Of African American Teen Males, Dorothy Farrow

Doctoral Dissertations and Projects

This quantitative study examined the relationship among parenting styles, the use of biblical principles in parenting, and the problem-solving skills of African American male teenagers aged 14 to 17 years in Cuyahoga County, Ohio, as perceived by their parents or guardians. The study addressed a significant gap in existing literature by integrating biblical teachings with established psychological theories on parenting. The primary theoretical frameworks included Baumrind's parenting styles theory and Bandura's social cognitive theory. Using the Kruskal–Wallis H and chi-square tests, the study assessed the potential relationships among parenting styles, biblical use in parenting, and parent-perceived problem-solving skills of their …


Experiences Of Victim Advocates Serving Military Sexual Assault Victims In The State Of New York: A Phenomenological Study, Neisha Louhar Jan 2026

Experiences Of Victim Advocates Serving Military Sexual Assault Victims In The State Of New York: A Phenomenological Study, Neisha Louhar

Doctoral Dissertations and Projects

The purpose of this phenomenological study is to describe victim advocates’ (VAs’) experiences serving victims of sexual assault (SA) in the State of New York. Current researchers emphasize experiences in the areas of professional satisfaction, development of new skills, and work relationships. The theories guiding the current research are Maslow’s hierarchy of needs and social cognitive theory (SCT). Maslow’s hierarchy of needs suggests that individuals are motivated to meet their needs in a specific order. Social cognitive theory’s observational learning shapes decision-making factors. have an important role in supporting victims of SA emotionally. Understanding victims’ experiences can provide awareness of …


Partners No More? Government And Philanthropy Navigate A Fractured Relationship, Jill Roof, Jeff Williams Jan 2026

Partners No More? Government And Philanthropy Navigate A Fractured Relationship, Jill Roof, Jeff Williams

Research, Reports, and Publications

No abstract provided.


Beyond Good Intentions, Nonprofits Must Show Good Work To Build Trust, Emily Doebler, Jennifer Lawson, Brenda Falk Jan 2026

Beyond Good Intentions, Nonprofits Must Show Good Work To Build Trust, Emily Doebler, Jennifer Lawson, Brenda Falk

Research, Reports, and Publications

No abstract provided.


Community-Led Movements Are Driving Climate Action, Trish Abalo, Emily Doebler Jan 2026

Community-Led Movements Are Driving Climate Action, Trish Abalo, Emily Doebler

Research, Reports, and Publications

No abstract provided.


The Evolving Landscape Of Philanthropy: Collective Practices, Digital Tools, And The Search For Connection, Michael D. Layton Jan 2026

The Evolving Landscape Of Philanthropy: Collective Practices, Digital Tools, And The Search For Connection, Michael D. Layton

Research, Reports, and Publications

No abstract provided.


Egfr Inhibitor-Resistant Lung Cancers Exhibit Collateral Sensitivity To A Covalent, Cysteine-Independent Keap1 Oligomerizing Molecular Bridge, Christopher F Bassil, Kerry Dillon, Gray R Anderson, Benjamin Mayro, Kayleigh N Askin, Peter S Winter, Stefan Harry, Samuel Gruber, Tierney M Hall, Jacob P Hoj, Christian Cerda-Smith, Haley M Hutchinson, Shane T Killarney, Ava Heffernan, Caroline Teddy, Katherine R Singleton, Li Qin, Kévin Jubien-Girard, Cécile Favreau, Guillaume Robert, Barr Tivon, Ella Livnah, Nir London, Rachid Benhida, Patrick Auberger, Ann Marie Pendergast, Liron Bar-Peled, David M Lonard, Anthony R Martin, Alexandre Puissant, Kris C Wood Jan 2026

Egfr Inhibitor-Resistant Lung Cancers Exhibit Collateral Sensitivity To A Covalent, Cysteine-Independent Keap1 Oligomerizing Molecular Bridge, Christopher F Bassil, Kerry Dillon, Gray R Anderson, Benjamin Mayro, Kayleigh N Askin, Peter S Winter, Stefan Harry, Samuel Gruber, Tierney M Hall, Jacob P Hoj, Christian Cerda-Smith, Haley M Hutchinson, Shane T Killarney, Ava Heffernan, Caroline Teddy, Katherine R Singleton, Li Qin, Kévin Jubien-Girard, Cécile Favreau, Guillaume Robert, Barr Tivon, Ella Livnah, Nir London, Rachid Benhida, Patrick Auberger, Ann Marie Pendergast, Liron Bar-Peled, David M Lonard, Anthony R Martin, Alexandre Puissant, Kris C Wood

Faculty, Staff and Students Publications

Targeted therapies have revolutionized cancer care. Unfortunately, most patients develop refractory, multifocal resistance to these therapies within a matter of months. Here, we demonstrate that the evolution of resistance to EGFR inhibitors in EGFR-mutant non-small cell lung cancer endows cells with hypersensitivity to a PAINS-like small molecule, MCB-613. Systematic proteomic, functional genomic, and biochemical studies revealed that MCB-613 binds KEAP1 in a covalent, cysteine-independent fashion, acting as a divalent molecular bridge that relies upon lysine residues in the KEAP1 dimerization domain to join monomers of KEAP1 together. Oligomerization of KEAP1 by MCB-613 sets into motion a fatal cascade of KEAP1 …


Developing Pattern Recognition And Interpretable Convolutional Neural Network Based Frameworks For Identifying Drug Resistant And Pan Cancer Mirnas From Expression Data, Joginder Jsingh Jan 2026

Developing Pattern Recognition And Interpretable Convolutional Neural Network Based Frameworks For Identifying Drug Resistant And Pan Cancer Mirnas From Expression Data, Joginder Jsingh

Doctoral Theses

Micro Ribonucleic Acids (miRNAs) are short length (∼24) non-coding RNAs and are considered as key biomarkers in cancer diagnosis and treatment. They play a vital role in classifying cancer patients from normal ones and drug resistant patients from control ones. The control patients are those who have not received any drug for cancer treatment. The objective is to identify a subset of miRNAs those help in the classification of the patients using expression data. The thesis is comprised of four contributory chapters in addition to an introduction and conclusion. In the first two contributory chapters, computational methods for ranking and …


Progress And Challenges In Profiling Protein-Rna And Protein-Associated Rna-Rna Interactions, Zhuoyi Song, Eric L Van Nostrand Jan 2026

Progress And Challenges In Profiling Protein-Rna And Protein-Associated Rna-Rna Interactions, Zhuoyi Song, Eric L Van Nostrand

Faculty, Staff and Students Publications

RNA binding proteins (RBPs) play essential roles in post-transcriptional gene regulation by interacting with a wide range of RNA targets. In addition to regulating RNA processing via individual RBP-RNA interactions, there is a growing appreciation of the regulatory impact of protein-associated RNA-RNA interactions that include both well-studied examples of small regulatory RNAs (e.g. microRNAs, snRNAs, snoRNAs, piRNAs) guiding ribonucleoprotein complexes to their targets as well as structured RNA elements defining the interaction landscape for an RBP. To elucidate the full scope of RBP-RNA interactions, CLIP ( crosslinking and immunoprecipitation)-based methods have emerged as powerful tools. Even with the wide application …


Ophiobolin A Impacts Mitochondrial Redox Biology In An Epithelial-Mesenchymal Transition (Emt)-Specific Manner, Haleigh N Parker, Yongfeng Tao, Jenna Tobin, Kayla L Haberman, Samantha Davis, Emily York, Alysia Martinez, Nobuyuki Matsumoto, Jaquelin Aroujo, Jun Hyoung Park, Bernd Zechmann, Benny Abraham Kaipparettu, Angela Boari, Christie M Sayes, Antonio Evidente, Alexander Kornienko, Benjamin Cravatt, Daniel Romo, Joseph H Taube Jan 2026

Ophiobolin A Impacts Mitochondrial Redox Biology In An Epithelial-Mesenchymal Transition (Emt)-Specific Manner, Haleigh N Parker, Yongfeng Tao, Jenna Tobin, Kayla L Haberman, Samantha Davis, Emily York, Alysia Martinez, Nobuyuki Matsumoto, Jaquelin Aroujo, Jun Hyoung Park, Bernd Zechmann, Benny Abraham Kaipparettu, Angela Boari, Christie M Sayes, Antonio Evidente, Alexander Kornienko, Benjamin Cravatt, Daniel Romo, Joseph H Taube

Faculty, Staff and Students Publications

Breast cancer progression is facilitated by the epithelial to mesenchymal transition (EMT), generating cancer cells with enhanced metastatic capacity and resistance to chemotherapeutics. The fungus-derived sesterterpenoid natural produce compound, ophiobolin A (OpA), possesses nanomolar cytotoxic activity and a high therapeutic index, although its molecular targets and mechanism of action are not well characterized. Herein, we utilized a model of mammary epithelial cells and breast cancer cell lines with and without EMT features to characterize the mechanism of selectivity towards EMT(+) cells by OpA. Proteins interacting with OpA in EMT(+) cells, including mitochondrial glutathione transporter SLC25A40, were identified through via mass …


Resolution Of A Human Chromosomal Mystery: Evolutionary Complexity Revealed, Jeffrey Rogers Jan 2026

Resolution Of A Human Chromosomal Mystery: Evolutionary Complexity Revealed, Jeffrey Rogers

Faculty, Staff and Students Publications

The human complement of chromosomes differs from our closest primate relatives by virtue of a unique chromosome fusion event. In this issue of Cell Genomics, Yang et al. provide the first detailed analysis of the site of chromosome fusion and reconstruct the complex evolutionary relationships among the genomic elements within the human fusion site and their related sequences in our great ape relatives.