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Potensi Pakan Serat Dan Daya Dukungnya Terhadap Populasi Ternak Ruminansia Di Wilayah Kabupaten Garut, U. Hidayat Tanuwiria, A. Yulianti, A. Mushawwir

Jurnal Ilmu Ternak Universitas Padjadjaran

Penelitian ini bertujuan untuk mempelajari potensi pakan asal limbah tanaman pangan dan daya dukungnya terhadap populasi ternak ruminansia di wilayah kabupaten Garut. Penelitian dilakukan dengan cara survey dan pengumpulan data sekunder.  Hasil penelitian menunjukkan bahwa Potensi pakan asal rumput alam dan jerami asal limbah tanaman pangan di seluruh wilayah kabupaten Garut adalah 414.211,1 ton bahan kering (BK) yang terdiri atas 151.395,6 ton BK asal rumput dan 262.815,5 ton BK asal limbah tanaman pangan. Daya dukung pakan terhadap populasi ternak adalah 124.706 satuan ternak (ST), yang terdiri atas 45.580,5 ST ternak ruminansia kecil dan 79.125,5 ST ternak ruminansia besar.

Kata Kunci …

Penggunaan Rumput Laut Dan Sekam Padi Sebagai Sumber Serat Dalam Ransum Terhadap Kadar Lemak Karkas Babi, K. Budaarsa, P.H. Siagian, Kartiarso

Jurnal Ilmu Ternak Universitas Padjadjaran

Penelitian-penelitian  yang telah dilakukan menunjukkan adanya suatu hubungan yang sangat kuat antara penyakit jantung dengan tingginya tingkat kolesterol plasma pada manusia dan spesies yang lainnya, termasuk babi. Hal ini sebabkan adanya persamaan anatomi dan fisiologi angara babi dan manusia,  informasi terhadap faktor-faktor yang mempengaruhi tingkat lemak tubuh di manusia dapat direfleksikan dengan kondisi yang sama pada babi. Suatu review terhadap beberapa beberapa literatur pada manusia bahwa kandungan  serat pada makanan dapat mereduksi lemak tubuh.  Babi  Landrace lepas sapih sebanyak 35 ekor dengan berat antara 8 – 10 kg telah digunakan untuk menentukan pengaruh pemberian rumput laut dan sekam padi sebagai …

Pengaruh Pemberian Antanan (Centella Asiatica) Sebagai Penangkal Cekaman Panas Dalam Ransum Broiler Yang Mengandung Hidrolisat Bulu Ayam, Engkus Kusnadi

Jurnal Ilmu Ternak Universitas Padjadjaran

Penelitian telah dilaksanakan untuk mempelajari pengaruh pemberian antanan (Centella asiatica) sebagai penangkal anti stress dalam ransum ayam broiler yang mengandung hidrolisat bulu ayam. Pada penelitian ini menggunakan 81 ekor broiler umur 10 hari. Terdapat dua macam perlakuan yang diberikan. Perlakuan pertama adalah tiga level kandungan antanan (0, 5, dan 10% kandungan antanan dalam ransum). Perlakuan kedua adalah tiga level tepung bulau (0, 4,8%, dan 9,6% tepung bulu dalam ransum). Hasil penelitian menunjukkan bahwa 5% kandungan antanan dalam ransum cenderung meningkatkan konsumsi pakan dan pertambahan berat badan, dan 4,8% kandungan tepung bulu dalam ransum tidak menurunakn konsumsi pakan dan …

Potensi Pakan Asal Limbah Tanaman Pangan Dan Daya Dukungnya Terhadap Populasi Ternak Ruminansia Di Wilayah Sumedang (Agriculture By Product As Potential Feed And Its Carrying Capacity In Sumedang), U. Hidayat Tanuwiria, N. Mayasari, A. Yulianti

Jurnal Ilmu Ternak Universitas Padjadjaran

Penelitian ini bertujuan untuk mempelajari potensi pakan asal limbah tanaman pangan dan daya dukungnya terhadap populasi ternak ruminansia di wilayah kabupaten Sumedang. Penelitian dilakukan dengan cara survey dan pengumpulan data sekunder.  Hasil penelitian menunjukkan bahwa Potensi pakan asal rumput alam dan jerami asal limbah tanaman pangan di seluruh wilayah kabupaten Sumedang adalah 284.784,72 ton bahan kering (BK) yang terdiri atas 86.937,65 ton BK asal rumput dan 197.847,07 ton BK asal limbah tanaman pangan. Daya dukung pakan terhadap populasi ternak adalah 85.739,79 satuan ternak (ST), yang terdiri atas 26.174,21 ST ternak ruminansia kecil dan 59.565,58 ST ternak ruminansia besar. Potensi protein …

Pemanfaatan Gelatin Tepung Sagu (Metroxylon Sago) Sebagai Bahan Pakan Ternak Ruminansia (Utilization Of Sago (Metroxylon Sago) Gelatin As Feed Ruminant), Harry Triely Uhi

Jurnal Ilmu Ternak Universitas Padjadjaran

Telah dilakukan penelitian pemanfaatan gelatin sagu sebagai bahan pakan ternak ruminansia. Tujuan penelitian untuk mengetahui suhu, waktu dan ratio volume air yang tepat selama pemanasan sampai terbentuknya gelatinisasi. Justifikasi terjadinya proses gelatinisasi didasarkan atas rusaknya bentuk granula yang dilihat dengan  mikroskop elektron dan mikroskop polarisasi. Perlakuan yang digunakan R1 (Tepung sagu 100 gram + suhu   80 ⁰C); R2 (Tepung sagu 100 gram + suhu   85 ⁰C); R3 (Tepung sagu 100 gram + suhu   90 ⁰C); R4 (Tepung sagu 100 gram + suhu   95 ⁰C); dan R5 (Tepung sagu 100 gram + suhu 100 ⁰C). Parameter …

Pengaruh Tepung Cangkang Rajungan (Portunus Pelagicus) Sebagai Sumber Kitin Dalam Ransum Terhadap Kandungan Lemak Feses Dan Efisiensi Pakan Tikus Putih (Rattus Norvegiccus) Strain Wistar (The Effect Of Crabs Shells (Portunus Pelagicus) As A Source Of Chi, Muhamad Fatah Wiyatna, Irba U. Warsono, Aminuddin Parakkasi

Jurnal Ilmu Ternak Universitas Padjadjaran

Cangkang rajungan mengandung kitin yang persentasenya paling besar berupa polisakarida. Kitin dan derivat-derivatnya telah banyak digunakan dalam berbagai keperluan terutama untuk kesehatan. Penelitian ini dilakukan dengan tujuan untuk mengetahui pengaruh pemberian tepung rajungan sebagai sumber kitin terhadap efisiensi pakan dan kandungan lemak feces tikus putih Rattus norvegicus) strain Wistar. Penelitian menggunakan rancangan acak lengkap pola faktorial 2x5 dengan tiga kali ulangan. Faktor pertama adalah jenis kelamin dan kedua level tepung rajungan yaitu 0%, 5%, 10%, 15%, and 20%. Hasilnya penelitian menunjukkan tidak ada interaksi antara jenis kelamin dengan kandungan teung rajungan dalam ransum. Kandungan lemak dalam feces tertinggi diperoleh …

Pengaruh Lama Penyimpanan Semen Cair Ayam Buras Pada Suhu 5 0c Terhadap Periode Fertil Dan Fertilitas Sperma (The Storage Time Effect Of The Local Chicken Chilled Semen At 5 0c On Fertility And Fertile Period Of Sperm), Nurcholidah Solihati, Ruhijat Idi, Rangga Setiawan, I.Y. Asmara

Jurnal Ilmu Ternak Universitas Padjadjaran

Tujuan penelitian ini untuk mengetahui sejauh mana pengaruh lama penyimpanan semen cair ayam buras pada suhu 5⁰C terhadap periode fertil dan fertilitas sperma.  Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) dengan 3 perlakuan dan setiap perlakuan diulang 6 kali.  Lama penyimpanan yang digunakan dalam penelitian ini adalah penyimpanan 1 jam (0 hari), 24 jam (1 hari) dan 48 jam (2 hari).  Peubah yang diukur adalah periode fertil dan fertilitas sperma. Data yang diperoleh dianalisis dengan analisis sidik ragam, dan untuk mengetahui perbedaan antar perlakuan diuji dengan menggunakan uji jarak berganda Duncan. Hasil penelitian menunjukan bahwa lama penyimpanan semen …

Dietary Nitrate Supplementation Worsens Resistance Exercise Performance In Resistance-Trained Females, Sydney N. Brennan, Raymond T. Gerardo, Trevor J. Molnar, Justin M. Foster, Ryan Tran, Kyle S. Geppert, Christopher B. Sottile, Michael Egiazarian, Abigail F. Ballhagen, Stewart D. Gonzalez, Adam Pennell, Rachel Tan

International Journal of Exercise Science: Conference Proceedings

Dietary nitrate supplementation appears to preferentially target type II muscle fibers for beneficial effects; however, research examining the efficacy of nitrate in females and resistance exercise is scarce. PURPOSE: To investigate if dietary nitrate, provided as concentrated nitrate-rich beetroot juice (BR), improved resistance exercise performance in back squat and bench press compared to nitrate-depleted beetroot juice (PL) in resistance-trained females. METHODS: Eighteen resistance-trained females aged reported to the lab for a total of four visits over a 2-week period. Participants performed a one repetition maximum protocol (1RM) and familiarization to the experimental protocol, and were assigned in a randomized, double-blind …

Glycemic Control After Meals On People With Type 2 Diabetes And Prediabetes Following Resistance Exercise, Isaac Chapman, Kosar Valaei, Oscar Chavez, Marissa Ramirez, Jacob Dawes, Maja Gebauer, Christine M. Mermier, Jonathan Little, Luotao Lin, Gretchen M. Ray, Roberto Mota Alvidrez, Zachary A. Mang, Fabiano Amorim, Valmor Tricoli, Flavio De Castro Magalhaes

International Journal of Exercise Science: Conference Proceedings

Resistance exercise (RE) has been shown to improve glycemic control after a meal in type 2 diabetes (T2D) and prediabetes under controlled laboratory settings. PURPOSE: To investigate the effects of RE on glycemic control in a free-living environment. METHODS: This was a 4-arm randomized crossover study involving 22 participants with T2D (n=12) or prediabetes (n=10). Glucose was monitored using a continuous glucose monitoring device through the experimental situations that involved three separate exercise sessions: a high-intensity RE session (3 sets x 8 reps, 75%-1RM, 120 sec interval), a rest-redistribution RE session (6 sets x 4 reps, 75%-1RM, 60 sec interval), …

Body Composition Of Older Active Adults: The Huntsman Senior Games Study, Abby M. Hansen, Dale R. Wagner Facsm, Heather Feeny, Paxton Catillon, Alyssa Mcnutt, Elizabeth Cafferty, Ben Taylor, Matthew Densley, Nicolas Clark, Andrew Creer

International Journal of Exercise Science: Conference Proceedings

Body composition variables are important when it comes to studying athletic performance. With an aging population, being actively engaged in athletic competition in one’s “golden years” is more common than in previous generations. However, there is a lack of normative data for senior athletes relative to their younger counterparts. PURPOSE: The purpose of this study was to analyze the correlation between age and both body fat percentage (%BF) and fat-free mass index (FFMI) in senior athletes and classify the percentile ranks of these body composition variables. METHODS: Data were collected using an InBody 770 Multi-Frequency Bioelectrical Impedance Analysis machine. Data …

Effects Of Hypobaric Hypoxia During Intermittent Cycling Bouts On Markers Of Acute Kidney Injury, Jacob D. Dawes, Alyssa R. Bailly, Jonathan W. Specht, Christopher B. Hart, Mateo Griego, Marissa Ramirez, Kaia G. Allen, Alexander Smaragdas, Fabiano T. Amorim

International Journal of Exercise Science: Conference Proceedings

Many individuals travel to high altitudes for recreational or occupational purposes. Hypobaric hypoxia (HH) at altitude decreases arterial oxygen saturation (SaO₂), reduces oxygen delivery to tissues, and can adversely affect organ function. Exercise, independent of HH, significantly decreases renal blood flow (RBF). Therefore, performing exercise in HH may further impair oxygen delivery and place additional strain on the kidneys. While the impact of chronic HH on kidneys has been documented, there is limited research on the risk of acute kidney injury (AKI) under these conditions. PURPOSE: To investigate the effects of acute HH exposure during intermittent exercise …

Can Passive Water Immersion Shape Force Production Capacity?, Joonsun Park, Talin Louder

International Journal of Exercise Science: Conference Proceedings

Previous studies have shown mechanistic neurophysiological evidence to foster motor cortical and plasticity alongside improved cerebral perfusion. Although evidence remains limited, these neural effects suggest passive immersion may enhance force output capacity. PURPOSE: This study aimed to investigate the acute effects of passive water immersion in a seated position on lower-extremity isometric strength as measured by isometric mid-thigh pull (IMTP) performance on land. METHODS: Thirty-three active young adults (age: 22.64 ± 4.18 years, height: 174.55 ± 10.28 cm, mass: 81.45 ± 18.77 kg) completed both land and water conditions (LC and WC), with pre- and post-tests using within …

Effect Of Previous Night Alcohol On Thermoregulatory And Physiological Strain During Prolonged Physical Work In The Heat, Marissa Ramirez, Jonathan W. Specht, Flavio De Castro Magalhaes, Fabiano Amorim, Whitley C. Atkins

International Journal of Exercise Science: Conference Proceedings

Many occupational workers engage in strenuous physical work in hot environments for prolonged periods, placing them at risk of heat-related illness due to increasing physiological strain identified by increasing core temperature (Tcore) and heart rate (HR). Lifestyle behaviors, such as smoking, caffeine and alcohol consumption, and sleep deprivation, may further exacerbate heat strain and increase susceptibility to heat-related illness. Notably, alcohol consumption the night before work, and the subsequent hangover, may amplify physiological strain by impairing heat dissipation. However, no previous studies have evaluated the impact of alcohol hangover on heat strain during physical work in the heat. PURPOSE: …

Evaluating The Accuracy Of Sex-Dependent Algorithms In Commercial Wrist-Worn Wearables For Exercise Energy Expenditure, Olivia R. Perez, Dustin W. Davis, Michael W. H. Wong, James W. Navalta Facsm

International Journal of Exercise Science: Conference Proceedings

Commercial wrist-worn wearable devices are popular among sports and health enthusiasts. Energy expenditure (EE) is a valuable measurement returned from these devices, but the accuracy is variable. A gap exists in sport and exercise science concerning sex-specific accuracy and input algorithms. Purpose: This study aimed to evaluate the sex-specific validity of five commercial wrist-worn wearable devices in estimating exercise EE, with indirect calorimetry as the criterion. Methods: 97 adult participants were outfitted with two devices (n = 20 per device), one set to the "female" sex option on the right wrist and the other set to the "male" sex …

Sex-Specific Changes In Pbmc Mitochondrial Respiration Following Acute Exercise, Ryan R. Moon

International Journal of Exercise Science: Conference Proceedings

Exercise-trained individuals exhibit greater immune system function, which may be attributed in part to enhanced peripheral blood mononuclear cell (PBMC) function. Exercise training is a potent stimulator of mitochondrial adaptation, which may help explain improvements in immunity. However, the mechanisms by which exercise acutely modulates PBMCs to promote beneficial adaptations remain unclear. Purpose: The purpose of this study was to test the hypothesis that a single bout of aerobic exercise modulates PBMC mitochondrial function. Methods: Twenty-eight healthy young adults (13 females, 15 males; age 21.84 ± 2.78 years) completed a graded exercise test (VO₂max: 41.4 ± 7.64 ml O₂·kg⁻¹·min⁻¹) followed …

The Association Between Muscular Strength And C-Reactive Protein Among Post-Menopausal Women: Effect Modification By Hormone Replacement Therapy, Sarah Krager, Bethany Barone-Gibbs, Amanda Paluch, Samantha Ehrlich, Amy Miller, William Boyer

International Journal of Exercise Science: Conference Proceedings

Previous studies suggest that the inflammatory marker C-reactive protein (CRP) may be elevated in post-menopausal women taking hormone replacement therapy (HRT). Muscular strength is associated with more favorable CRP profiles. However, this association has not been examined among post-menopausal women on HRT. PURPOSE: This study aims to examine the association of lower leg strength and CRP while considering potential effect modification by HRT using a representative sample of U.S. adults. METHODS: The final sample (n=1,238) included post-menopausal women (≥50 years) who participated in the 1999-2002 National Health and Examination Survey (NHANES). CRP was examined continuously and categorically (/dl vs 3-10 …

Possible Intervertebral Disc Disease Related To Ventricular Tachycardia In A Labrador Retriever, Nadthagarn Glaewketgarn, Sirilak Disatian Surachetpong

The Thai Journal of Veterinary Medicine

Ventricular arrhythmia (VA) is a common arrhythmia in dogs. Several extracardiac causes such as pain may contribute this condition. This case report describes a 9-year-old neutered male Labrador Retriever with ventricular tachycardia (VT) potentially related to severe neck pain due to intervertebral disc disease (IVDD). The dog was referred with a sign of inability to walk, tachypnea and an irregular heartbeat. Electrocardiography confirmed VT at 160-200 bpm and an increased cardiac troponin I level (35.22 ng/ml). Despite antiarrhythmic treatment, the VT persisted. Cardiac evaluation revealed no structural abnormalities. Interestingly, VT episodes were provoked by cervical palpation and resolved following analgesic …

A Critical Appraisal On The Injury Susceptibility Of Underground Metalliferous Mine Workers: Application Of Logistic Regression Model, Sudip Das, Falguni Sarkar, P.S. Paul, B.K. Pal

Journal of Sustainable Mining

The aim of this study is to analyze the occupational injury data of Indian underground metalliferous mines for scrutinizing the injury proneness of different groups of mine workers. In this context, injury records from 2011 to 2022 were obtained from underground metalliferous mines situated at Eastern part of India. The data were characterized and segregated based on different individual and workplace level variables. The workplace injury is categorized as ‘no injury’ and ‘all injury’. Subsequently, Frequency and Classification Based analysis (FCBA), Standardized Injury Rate (SIR) analysis and Logistic Regression Model (LRM) analysis were performed sequentially (FCBA-SIR-LRM) to predict the susceptibility …

Modulation Of Hypothalamic–Limbic Circuits Regulating Appetite In Response To Health Lifestyle In Obese Adults, Nour Shakir Rezaieg, Muthanna M. Awad

Karbala International Journal of Modern Science

Background: Overeating leads to obesity a low-grade inflammatory disease. In this context, aguati-related neuropeptide (AgRP) and ghrelin are pivotal players in appetite regulation, while chemerin is an adipose tissue-secreted adipokine that contributes to low-grade inflammation associated with obesity. Objective: This study used a healthy lifestyle program designed for each obese participant to identify diet-related neuro-hormonal changes in appetite regulation. Design, Setting, and Participants: This a longitudinal quasi-experimental controlled study was conducted from 1^st December 2024, to 30^th July 2025, at University of Anbar. The sample included 100 participants, 50 obese (weight between 100–140 kg) and 50 healthy participants …

Evaluation Of Mcf-7 Breast Cancer Cell Cytotoxic And Antioxidant Activities Of Peptide Fractions From Symbiotic Bacteria Of Jellyfish Catostylus Sp., Eka Sry Wahyuni, Ahyar Ahmad, Muhammad Nasrum Massi, Sofa Fajriah, Randi Rimpung, Muh. Akbar Ardiputra, Harningsih Karim, Irda Handayani

Karbala International Journal of Modern Science

Marine-derived symbiotic microorganisms are recognized as a promising source of bioactive compounds with potential therapeutic applications, yet research on jellyfish-associated bacteria remains limited. This study examines the bioactivity of peptide fractions derived from symbiotic bacteria isolated from the jellyfish Catostylus sp., collected from the coastal waters of South Sulawesi, Indonesia, with a focus on their anticancer and antioxidant properties. Following sample collection, the symbiont bacteria were isolated, enzymatically hydrolyzed, and purified before their biological activity was evaluated. Preliminary cytotoxicity screening using the brine shrimp lethality assay revealed that the extracellular peptide fraction (5–10 kDa) and intracellular peptide fraction (3–5 kDa) …

Betting On The Future By Re-Discovering The Past: History Of Hospital Infrastructure In Early Las Vegas And Southern Nevada, Aidy Weeks

Library Faculty Research

In the summer of 2025, the library director began reviewing resources available from the University Libraries Special Collections Portal to learn about early hospital infrastructure in Las Vegas and Southern Nevada. Using the keyword “hospital”, they reviewed 1,000 records to locate primary resources that could help tell the story of Las Vegas’s first hospital and Southern Nevada early history. In total, they located photos, oral histories, city documents, and newspaper articles, to help put together a timeline of which hospitals, current events, and key figures were critical in establishing a medical presence in Las Vegas and Southern Nevada. Information was …

20% Caloric Restriction Did Not Impact Bone Health Nor Exercise-Induced Elevations In Bone Mass In Young Female Rats, Ken D. Sumida, Brady Slater, Haley Folta, Kassandra Lee, Sarina Karwande, Quinton Wong, S. Victoria Jaque, Frank Frisch

Health Sciences and Kinesiology Faculty Articles

The purpose of this study was to determine if a 6-week 20% caloric restrictive (CR) diet, with or without resistance training, would impact bone health in growing young female rats. Forty female rats (~ 5 wks old) were randomly divided into the following groups: baseline (n = 8), sedentary fed a normal diet (N, n = 8), sedentary fed a 20% CR diet (D, n = 8), resistance trained fed a normal diet (NT, n = 8), and resistance trained fed a 20% CR diet (DT, n = 8). The exercise groups were conditioned to climb a vertical ladder …

Plasma Proteomic Profiling Reveals Distinct Protein Signatures Associated With Hepatocellular Carcinoma In Chronic Hepatitis B Infection, Sidnooma Véronique Zongo, Michael A. Bauer, Lassina Traore, Tegwinde Rebeca Compaore, Albert Théophane Yonli, Augustin Tozoula Bambara, Palwendé Romuald Boua, Roger Arsène Sombié, Oumar Barro, Sosthene K. Somda, Mahamoudou Sanou, Jeremy James Martinson, Jean Christopher Chamcheu, Lewis R. Roberts, Mitesh J Borad, Bolni Marius Nagalo, Alan J Tackett, Adama Sanou, Florencia Wendkuuni Djigma, Jacques Simpore

Faculty Publications

Background

Chronic hepatitis B virus (HBV) infection is a leading cause of hepatocellular carcinoma (HCC), yet reliable biomarkers for early detection and risk stratification remain limited. This study aimed to identify plasma proteins associated with disease progression from chronic HBV infection to HCC.

Methods

Plasma proteomic profiling was conducted using high-resolution LC–MS/MS on samples from healthy controls, chronic HBV carriers, patients with cirrhosis, and individuals with HBV-associated HCC. Differentially expressed proteins were identified through bioinformatics analysis, and protein–protein interaction networks were reconstructed to assess functional relevance.

Results

Eight proteins displayed distinct, stage-specific expression patterns along the disease continuum. ICAM1, TIMP1, …

California Couple Adds $3 Million To Scholarship Fund, Tina H. Hahn

University of Mississippi News

OXFORD, Miss. – Bill and Melanie Roper, of La Jolla, California, are deepening their commitment to University of Mississippi students by adding $3 million to the Bill and Melanie Roper Scholarship Endowment, which began with a $2 million gift in 2022.

Host-Derived Interleukin-1Α Drives Tumor Immunosuppression By Reprogramming Tumor-Associated Myeloid Cells, Manikanda Raja Keerthi Raja, Gourab Gupta, Grace Atkinson, Katie Kathrein, Alissa R. Armstrong, R. Michael Gower, Igor Roninson Ph.D., Eugenia Broude, Mengqian Chen Ph.D., Hao Ji, Chang-Uk Lim, Hongjun Wang, Daping Fan, Peisheng Xu Ph.D., Hexin Chen

Faculty Publications

Myeloid cells are highly heterogeneous and play key roles in establishing an immunosuppressive tumor microenvironment (TME), but the mechanisms controlling their differentiation remain unclear. Using orthotopic murine breast cancer models, we investigated how interleukin-1α (IL-1α) influences this process. Deletion of host Il1α resulted in rejection of transplanted tumors. Single-cell RNA sequencing identified CX3CR1⁺ macrophages as the main source of IL-1α in the TME. Il1α deficiency disrupted monocyte–macrophage differentiation, reducing CX3CR1⁺ macrophages and increasing iNOS⁺ macrophages. Myeloid cells from Il1α⁻/⁻ hosts induced lower PD-1 and CTLA-4 expression in co-cultured CD8⁺ T cells than those from wild-type hosts. CellChat analysis showed …

Quality Control Of Actinium-225 And 225ac-Radiopharmaceuticals: Francium-221 To Be Or Not To Be?, Miguel Toro-Gonzalez, Luke Wheeless, Vijai Kumar Reddy Tangadanchu, Cory Hawkins, Shannon Provo, William Smith, Michael Hommen, Dan Devries, Jim Harvey, Tyler Drum, Diane S Abou

2020-Current year OA Pubs

BACKGROUND: Actinium-225 radiopharmaceuticals have drawn great interest in cancer therapy due to their tumor-specific delivery of cytotoxic alpha-particles. Quality control (QC) is critical for these potent agents and there is currently no consensus for best practice of actinium-225 QC. Detection of actinium-225 (T

RESULTS: The plastic silicon scanner resulted in RCY% differences between 30 min and > 5 h evaluations, whereas the gas-filled proportional counter, when varying voltages, showed minor differences. Similarly, HPGe-TLC demonstrated equivalent RCY% between both equilibria. The NaI(Tl), LSC- TLC, and HPLC-gamma counting significantly underestimated RCY% or RCP% at 30 min. Considering gamma well counting LOQ and

CONCLUSION: …

Plans4care, A Web Application Providing Caregivers Personalized Solutions To Manage Dementia-Related Care Challenges: Proof Of Concept And Efficacy Trial, Laura N. Gitlin, Eric Jutkowitz, Catherine V. Piersol, Sokha Koeuth, Taylor Sivori, Melinda J. Webster, Rachel N. Barnett, David L. Roth

Department of Occupational Therapy Faculty Papers

OBJECTIVE: Few dementia caregivers have access to evidence-based support programs. Web applications (app) may address this gap. Plans4Care, a web app, provides caregivers with on-demand personalized solutions to address care challenges. We present results of a proof-of-concept study and describe a trial protocol to test efficacy.

METHODS: To use Plans4Care, caregivers respond to brief onboarding questions, assess dementia patients' cognitive function, identify care challenges, and generate "action plans" (personalized strategies). Telehealth sessions with dementia-trained care advisors are available. A proof-of-concept study evaluated a clickable prototype using standardized technology scales to determine if >75 % scored positively on four criteria (acceptability, …

Paywall Payout: A Three Year Review Of The Soml Open Article Fund, Aidy Weeks

Library Faculty Research

In 2022, the School of Medicine Library launched the Open Article Fund as a way to support faculty, residents, and fellows with their scholarly activities when submitting open access publications that would otherwise be ineligible for funding through the University Libraries fund which limited recipients to tenure-track faculty. After feedback from the Kirk Kerkorian School of Medicine Office of Research, The pilot fund was structured after the University Libraries funds with some modifications including awarding $2,000 instead of $1500 towards a publication, allowing for publications in hybrid journals, and requiring multi-author team submissions. The fund was initially supported by $30,000 …

Reducing Work-Related Screen-Time In Healthcare Workers During Leisure Time (Reduce Screen) - A Randomized Controlled Trial, Karsten Bartels, Karan Shah, Emelind Sanchez Rodriguez, Julie T Hoffman, Megan L Rolfzen, Juana Mora Valdovinos, Afton L Hassett, Daniel I Sessler

Faculty, Staff and Student Publications

The ubiquitous availability of work-related applications on personal devices makes healthcare workers prone to working during leisure time. We tested the hypothesis that an intervention to reduce work-related screen time during a weekend off reduces stress in healthcare workers in a pragmatic parallel design randomized controlled trial between November 2021 and November 2023. Healthcare workers using a smartphone with a work email application were eligible. Randomization was 1:1 to no treatment or a threefold educational intervention to: 1) activate automated responses to emails received, 2) reduce screen time, and 3) uninstall work applications from personal devices. The primary outcome was …

Foxo1 Inhibition And Fadd Knockdown Have Opposing Effects On Anticancer Drug-Induced Cytotoxicity And P21 Expression In Osteosarcoma Cells, Danielle Walker, Antanay Hall, Alexis Bonwell, Nancy Gordon, Danielle Robinson, Mario G Hollomon

Faculty, Staff and Student Publications

Forkhead box class O1 (FOXO1) and fas-associated death domain (FADD) regulate cell death pathways and homeostatic processes such as cell cycle progression and apoptosis. FADD phosphorylation promotes nuclear localization of FOXO1, and FOXO1 regulates FADD expression. Therefore, it is plausible that FOXO1 and FADD have synergistic or antagonistic effects on cell cycle regulation and the response to anticancer drug treatment in cancer cells. In the present study, we report that AS1842856-mediated inhibition of FOXO1 reverses anticancer drug-induced cytotoxicity, while FADD knockdown increases anticancer drug-induced cytotoxicity in osteosarcoma (OS). Reversed anticancer drug-induced cytotoxicity was accompanied by G2/M cell cycle arrest and …