Digital Commons Network^™

Payload Diversification Overcomes Resistance And Guides Sequential Antibody-Drug Conjugate Therapy In Breast Cancer, Dileep Reddy Rampa, Minji Seo, Nanae Ogata, Zhaoxuan Yang, Nithya Sridhar, Fujii Takeo, Chalothorn Wannaphut, Jennifer A Maynard, Kyoji Tsuchikama, George W Sledge, Naoto T Ueno, Jangsoon Lee

Faculty, Staff and Student Publications

Purpose: Antibody-drug conjugates (ADCs) have transformed the treatment of breast cancer. FDA-approved ADCs such as trastuzumab deruxtecan (T-DXd), sacituzumab govitecan (SG), and datopotamab deruxtecan (Dato-DXd) have demonstrated clinical benefit; however, drug resistance will almost inevitably emerge in the metastatic setting, and there is no established strategy for selecting subsequent ADCs after disease progression to the first exposure to the ADC. This study aimed to define mechanisms of acquired resistance and evaluate rational sequencing approaches.

Experimental design: We generated breast cancer cell lines resistant to T-DXd (TDXd-R) and SG (SG-R). We assessed antigen expression, internalization, and resistance pathways, including efflux transporter …

Mapping Post-Rainfall Recovery In Arid Regions Using A Hierarchical U-Net, Xin Hong

All Works

The United Arab Emirates (UAE) experienced an extreme rainfall event between April 15 and 17, 2024, and that resulted in severe flooding in its coastal regions. Dubai was among the most affected regions. This study applies a hierarchical deep learning model on PlanetScope imagery to detect flood inundation, quantify flood extent by land cover, and examine short-term recovery dynamics. While earlier work detailed the methodological development of a hierarchical U-Net model (Hong et al., in press), here we emphasize its application for monitoring resilience trajectories in an arid urban environment. Results show that approximately 22 km² of land was …

Metaverse-Enabled Digital Twins For Business And Smart Cities: Toward A Human-Centered Framework For Digital Transformation, Rasem Qudaih, Nicholas Caldwell, Imen Ben Salem, A. Karthi

All Works

Digital Twin (DT) technologies are increasingly changing how businesses and cities model, assess, and enhance complex systems. Traditional DTs have served as static representations of tangible assets, providing monitoring and predictive functionalities. However, minimal stakeholder engagement and a focus on specific sectors have often limited their full potential. The rise of the metaverse, reinforced by Extended Reality (XR) technologies, presents a unique chance to evolve DTs into immersive, interactive, and human-centered platforms for collaborative decision-making. This integration allows stakeholders to visualize and engage with multidimensional data in real time, facilitating predictive analysis, scenario planning, and participatory governance. In business environments, …

Assessing Mangrove Ecosystem Health And Identifying Optimal Planting Regions Using Remote Sensing And Gis In The Uae, Imen Ben Salem, A. Karthi, Yousef Nazzal

All Works

Mangrove forests play a critical role in carbon sequestration, biodiversity preservation, and coastal resilience, making their conservation and restoration essential in climate change mitigation. This study uses traditional field evaluations and remote sensing and geoinformatics (GIS) methods to examine how mangrove ecosystems in the United Arab Emirates (UAE) have changed over time and space. We used Landsat satellite data from 2001 to 2024 and a set of vegetation indices, including SMRI, NDVI, GNDVI, EVI, and NDCI, to examine spatial patterns in biomass distribution, vegetation density, and overall ecosystem health. CO2 sequestration is a bit more climate-impact resilient. Even though the …

Mapping Urban Vegetation Changes Using Planetscope Imagery And Gis: A Case Study Of The 2024 Dubai Flood, Sumayya Almansoori, Xin Hong

All Works

In April 2024, unexpected heavy rainfall triggered one of the most severe flooding events in Dubai’s recent history, causing widespread concern for urban infrastructure and green spaces. This study evaluates the flood’s impact on urban vegetation in South Dubai using high-resolution PlanetScope satellite imagery and the Normalized Difference Vegetation Index (NDVI). Vegetation conditions before and after the flood (April 14 and April 18–19, 2024) were quantified and compared using NDVI analysis within QGIS to assess changes in vegetation health and coverage. Results indicate significant declines in vegetation health in areas dominated by intensive turf management, such as Damac Hills and …

Spatially Distinct Cellular And Molecular Landscapes Define Prognosis In Triple-Negative Breast Cancer, Kavitha Mukund, Darya Veraksa, David Frankhouser, Lixin Yang, Jerneja Tomsic, Raju Pillai, Srijan Atti, Zahra Mesrizadeh, Daniel Schmolze, Jovanny Zabaleta, Xiao-Cheng Wu, Mary-Anne Leblanc, Lucio Miele, Augusto Ochoa, Victoria Seewaldt, Shankar Subramaniam

School of Medicine Faculty Publications

Triple-negative breast cancer (TNBC) is a prevalent breast cancer subtype with the lowest 5-year survival. Several factors influence outcomes, but their inherent molecular and cellular heterogeneity are increasingly acknowledged as crucial determinants. Here, we report on the spatio-molecular heterogeneity underlying TNBC tumors in a retrospective, treatment-naive cohort with differential prognoses (17 good prognoses [GPx] >15-year survival and 15 poor prognoses [PPx] < 3-year survival]) profiled using GeoMx Digital Spatial Profiler. Analyses reveal that epithelial and microenvironment (TME) states are transcriptionally distinct between groups. Invasive GPx epithelia show an increase in immune transcripts, with a more immune-rich TME (via IF). PPx epithelia, in contrast, are more metabolically and translationally active, with a mesenchymal/fibrotic TME. Pre-cancerous epithelia in PPx exhibit a presence of aggressiveness, marked by increased EMT signaling and complement activity. We identify distinct epithelial gene signatures for PPx and GPx that can accurately classify diagnostic samples and likely inform therapy.

Expression Spectrum Of Te-Driven Transcripts In Human Adult Tissues, Benpeng Miao, Xinlong Luo, Amina Ademovic, Yushan Yang, Tao P Wu, Bo A Zhang

Faculty, Staff and Students Publications

Background

Transposable elements (TEs) are vital components of eukaryotic genomes and have played a critical role in genome evolution. Although most TEs are silenced in the mammalian genome, increasing evidence suggests that certain TEs are actively involved in gene regulation during early developmental stages. However, the extent to which human TEs drive gene transcription in adult tissues remains largely unexplored.

Results

In this study, we systematically analyze 17,329 human transcriptomes to investigate how TEs influence gene transcription across 47 adult tissues. Our findings reveal that TE-driven transcripts are broadly expressed in human tissues, contributing to both housekeeping functions and tissue-specific …

A Bovine Cell Line Resistant To Japanese Encephalitis Virus Entry But Permissive To Post-Entry Replication, Sang-Im Yun, Young-Min Lee

Animal, Dairy, and Veterinary Science Faculty Publications

Japanese encephalitis virus (JEV) is a mosquito-borne zoonotic orthoflavivirus that poses a significant global health threat. It causes severe neuroinflammatory disease in humans and reproductive failure in swine. Because of the broad host range and cell tropism of JEV, identifying animal cell lines resistant to infection has been a persistent challenge. In this study, we demonstrate that Madin–Darby bovine kidney (MDBK) cells are resistant to JEV infection yet remain fully permissive to viral replication when transfected with viral genomic RNA. Using immunoblotting, immunofluorescence, and flow cytometry, we show that MDBK cells, unlike the highly susceptible baby hamster kidney (BHK-21) cells …

Cxcr4-Targeted Theranostics In Non-Hodgkin Lymphoma: Present Evidence And Future Directions, Marcus Yoakam, Uma A. Obalapuram, Kameron Hahn, Samir Dalia

Student Publications

Non-Hodgkin lymphoma (NHL) is a biologically heterogeneous group of lymphoid malignancies with variable clinical outcomes despite advances in chemotherapy, immunotherapy, and cellular therapies. The C–X–C chemokine receptor 4 (CXCR4)/ C–X–C motif chemokine ligand 12 (CXCL12) axis plays a central role in lymphocyte trafficking, survival, and tumor microenvironment interactions. It is frequently dysregulated in NHL, making it an attractive target for precision oncology. CXCR4- directed theranostics combines molecular imaging and targeted radionuclide therapy, enabling real-time assessment of receptor expression, patient stratification, and personalized treatment delivery. Diagnostic positron emission tomography imaging using ⁶⁸Ga-pentixafor reliably visualizes CXCR4-expressing disease, while therapeutic agents, such …

Seizure Presentation Of A Grade Ii Astrocytoma In A Patient With Ollier's Disease: A Case Report And Brief Review, Marissa Vail, Hunter Slosser, Robert Steele, Brian Curtis, Daniel Henry

Student Publications

Ollier's disease (enchondromatosis) is a dysplasia of cartilage characterized by multiple enchondromas. Current evidence supports a measurable prevalence of concurrent gliomas in patients with Ollier's disease. In patients with Ollier's disease, isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) mutations were shown to be a predisposing factor to the development of astrocytomas in conjunction with subsequent mutations in adenosine triphosphate (ATP)-dependent helicase ATRX (ATRX) and tumor protein p53 (TP53). We present the case report of a 21-year-old man with an adolescent diagnosis of Ollier's disease who developed a grade II astrocytoma in early adulthood. The patient presented to the …

Expression Spectrum Of Te-Driven Transcripts In Human Adult Tissues, Benpeng Miao, Xinlong Luo, Amina Ademovic, Yushan Yang, Tao P Wu, Bo A Zhang

2020-Current year OA Pubs

BACKGROUND: Transposable elements (TEs) are vital components of eukaryotic genomes and have played a critical role in genome evolution. Although most TEs are silenced in the mammalian genome, increasing evidence suggests that certain TEs are actively involved in gene regulation during early developmental stages. However, the extent to which human TEs drive gene transcription in adult tissues remains largely unexplored. RESULTS: In this study, we systematically analyze 17,329 human transcriptomes to investigate how TEs influence gene transcription across 47 adult tissues. Our findings reveal that TE-driven transcripts are broadly expressed in human tissues, contributing to both housekeeping functions and tissue-specific …

Establishing Functional Communication Responses And Mands: A Scoping Review Of Teaching Procedures And Implications For Future Investigation., Kyle W. Dawson, Amanda N. Zangrillo, Samantha J. Bryan, Rebecca J. Barall, Colin G. Wehr

Manuscripts, Articles, Book Chapters and Other Papers

The functional communication response (FCR) shares fundamental properties with the mand, with both responses linking the relevant motivating operation and the reinforcer maintaining a response. The FCR differs from the mand in that the communication response has the expressed intention of replacing challenging behavior by providing an outlet to access the same functional reinforcer. Research describes the development of mand and FCR repertoires; however, no research to date elucidates differences and similarities in how these repertoires are established. A scoping review was selected to systematically map and compare instructional procedures across FCT and mand training studies. In this scoping review, …

Beyond The Rash: Cutaneous Peripheral T-Cell Lymphoma As A Diagnostic Pitfall In Primary Care, Jared Hensley, Aura Calderon, Blake Martin, Cristina Kochi, Andres Suarez Parraga

School of Medicine Publications

Cutaneous manifestations of T-cell lymphomas may resemble common dermatologic or infectious conditions, increasing the risk of delayed recognition. We report a 78-year-old woman with known peripheral T-cell lymphoma (PTCL) who presented with a rapidly progressive, diffuse erythematous rash accompanied by cervical lymphadenopathy. Initial evaluation prioritized more common etiologies; however, inpatient medicine broadened the differential diagnosis, prompting early hematology and oncology consultation. Contrast-enhanced CT of the neck demonstrated multiple enlarged, partially necrotic left cervical lymph nodes consistent with disease progression. After multidisciplinary discussions and consideration of prognosis, the patient elected palliative-focused management with oncology follow-up. This case underscores the importance of …

Educational Design Models In Transition: A Comparative Review, Tofan Stofiana, Yeti Mulyati, Andoyo Sastromihardjo, Dadang Sunendar

Journal of Educational Research and Practice

A persistent gap between educational theory and classroom practice underscores the need for methodological approaches that are reflective, participatory, and context responsive. This study provides a comparative review of four major educational design models, including research and development (R&D); Analysis, Design, Development, Implementation, and Evaluation (ADDIE); design-based research (DBR); and educational design research (EDR), to examine their theoretical orientations and contemporary applications. A systematic literature synthesis and bibliometric mapping were conducted on 80 peer-reviewed journal articles indexed in Scopus between 2020 and 2025. The findings reveal that ADDIE remains the most frequently applied framework due to its procedural clarity and …

Analysis Of The Effect Of Neuro-Developmental Treatment (Ndt) On Gross Motor Function In Children With Spastic Diplegic Cerebral Palsy: A Systematic Review, Haunan Naja Izdihar, Aditya Denny Pratama

Jurnal Vokasi Indonesia

Effectiveness of Neurodevelopmental Treatment (NDT) in Children with Spastic Diplegia Cerebral Palsy: A Systematic Review

Background:
Neurodevelopmental Treatment (NDT) is commonly used in pediatric rehabilitation to improve motor function in children with cerebral palsy, particularly those with spastic diplegia.

Methods:
This systematic review followed PRISMA 2020 guidelines. Seven studies published between 2018 and 2024 were identified through electronic databases, including PubMed, Scopus, ProQuest, ScienceDirect, SpringerLink, Cochrane Library, Google Scholar, and Crossref.

Results:
The included studies reported improvements in gross motor function, posture, balance, and daily functional independence following NDT, particularly when combined with other therapeutic interventions. However, outcome measures and …

Father Knows Best? Not Here: Metaphors Of Kinship And Kingship In Haudenosaunee, Aristotelian, And Confucian Political Thought, Ian Kalman

Comparative Philosophy

The notion that the organization of large-scale social structures are rooted in domestic ones has a longstanding history in both Chinese and Greek classical political philosophy. Aristotle and Confucius independently reasoned that a good family, one with a strong father, mapped onto a good state, one with a strong king - though they differed on the details. While there is a strong literature juxtaposing these two titans, less attention has been paid to how their ideas compare with other philosophical traditions. This article provides an anthropological intervention to the comparative study of Confucius and Aristotle – while both autonomously argued …

Procedure To Evaluate Artificial Intelligence (Ai) Output For Educational And Clinical Tasks, Lynn Gilbertson, Cody Marie Busch, Jon Spike, Kaitlin Demoss, Jae Thompson

Teaching and Learning in Communication Sciences & Disorders

As generative artificial intelligence (AI) becomes more ubiquitous and accessible, there is a call to promote awareness, implementation, and evaluation skills among AI users. Free AI platforms offer unprecedented opportunities to transform how education and healthcare tasks are approached. However, a process for evaluating AI output has yet to be standardized. The current study implemented a structured process for guiding graduate and undergraduate students through critical evaluations of various AI platforms, promoting students' critical thinking and career readiness.

Assessing Learning In Simulation Learning Experiences In Graduate Programs For Speech-Language Pathology: A Phenomenological Study, Robyn Walker, Casey Ozaki

Teaching and Learning in Communication Sciences & Disorders

The purpose of this study was to use qualitative inquiry to explore how faculty assess student learning in clinical simulation-based learning experiences (SBLEs) used to demonstrate clinical competence in graduate programs in Communication Sciences and Disorders: Speech-Language Pathology (CSD). The following research questions were addressed: How do faculty experience the assessment of learning in SBLE? In what ways do faculty assess student learning in SBLE specifically designed to meet clinical competency standards? What, if any, effect has the COVID-19 pandemic had on the use of SBLE and assessment of student learning used to address clinical competency standards? A total of …

Uconn Lco/Gr Battery Fast Charging Dataset, Sina Navidi, Sourav Das, Benjamin Nowacki, Pranav Shrotriya, Jun Xu, Chao Hu

REIL Datasets

This dataset comprises 76 Powerstream LiR 2032 lithium cobalt oxide/graphite (LCO/Gr) coin cells used to study Coulombic efficiency and long-term degradation under fast charging conditions. The dataset includes 40 cells tested using SOC-sweep experiments and 36 cells evaluated using benchmark fast charging protocols. SOC-sweep experiments were conducted at four target SOH levels (100%, 90%, 80%, and 70%) and across multiple charging C-rates (1.5C–3.5C) to characterize the dependence of Coulombic efficiency on SOC, C-rate, and SOH. Benchmark tests were designed to assess protocol-dependent degradation and consisted of repeated blocks of charge-discharge cycling followed by reference performance tests (RPTs) to measure capacity. …

Profile: Susan Feldman

Creative Nonfiction Magazine

No abstract provided.

If And When, Mimi Schwartz

Creative Nonfiction Magazine

No abstract provided.

Miss Eartha M. M. White, President The Clara White Mission Calling Card

Eartha M. M. White Textual Material

Card: Calling card with caption: Miss Eartha M. M. White, President of the Clara White Mission S4-1192

Minding Machines: A Note On Alienation, Sascha Engel

Fast Capitalism

This paper discusses an underrepresented dimension of contemporary alienation: that of machines, and particularly of computing machines. The term 'machine' is understood here in the broadest sense, spanning anything from agricultural harvesters to cars and planes. Likewise, 'computing machine' is understood broadly, from homeostatic machines, such as thermostats, to algorithmic universal machines, such as smartphones. I suggest that a form of alienation manifests in the functionalist use and description of machines in general; that is, in descriptions of machines as mere tools or testaments to human ingenuity. Such descriptions ignore the real and often capricious existence of machines as everyday …

Max Weber's Odyssey: The Wild West, The Frontier, And The Capitalist Spirit, David Norman Smith

Fast Capitalism

This article examines one aspect of Weber's thinking with respect to the United States: his view of frontier regions as new horizons for capitalism. This was not an incidental or side issue for Weber, whose famed analysis of The Protestant Ethic and the Spirit of Capitalism was only half-finished when he traveled through the United States in 1904. Nor is Weber's outlook on this topic immaterial for contemporary historians, many of whom now affirm quasi-Weberian views under such rubrics as "the New Western" history. A full account of Weber's notion of the frontier would exceed the limits of a journal …

Divining Domination: Steve Bannon As A Political Mystagogue, Tony Allen Feldmann

Fast Capitalism

Right-wing commentators (on tv, radio, newspapers, documentaries, or the internet) are often considered a source of misinformation and radicalization in American politics. Understanding the role of such commentators in the political sphere has taken on new significance since the election of Trump, who regularly takes talking points as well as political advice from prominent figures in right-wing media. The purpose of these political "shock jocks" also extends beyond mere political commentary: They offer their audience a framework for understanding the world. This framework contains certain reified perceptions of society and history. Durkheim and those working in his tradition have long …

Hamlet's Father: Hauntology And The Roots Of The Modern Self, Lukas Szrot

Fast Capitalism

In his 1949 work Hamlet's Ghost, Richard Flatter wrote of the ghost of Hamlet's father that the play ultimately belongs to him, to the ghost.   Modernity, like the play, belongs to its ghosts, to its dead fathers haunting their wayward sons, the metaphysical specters it imperfectly endeavors to exorcise. Critical theory has often focused on the possibility, and the contours, of a utopia populated by liberatory spirit and liberated persons. Less well explored, however, are the implications for tradition, religion, and the transmission of culture at a metaphorical echelon—those ostensibly "pre-modern" ideas which the broader project of Enlightenment liberalism never …

Sociopoetics In The Works Of Shakespeare, Thomas Bechtold

Fast Capitalism

This study is meant to develop an immanent critique following the dialogism of socio-poetics in the literary criticism of Mikhail Bakhtin. Socio-poetics in the reception and composition of Shakespeare's works reflect the first intimations of social and political transformation to a modern nationalized society from a premodern feudal society. This study explores Shakespeare's use of metaphor through his dramatizations and characterizations at the dawn of modernity and the decline of feudalism: identifying contradictions and tensions that intimate this transformation in English society and language, and, providing an approach to this globalizing language that partakes in simultaneous modes of confabulation and …

The Beatings Will Continue Until Morale Improves, Mark P. Worrell

Fast Capitalism

Introduction to the Symposium: "Cultural Reflections of Capital."

Author Biography

Mark P. Worrell, SUNY Cortland Professor, Retired

Full Issue, Fast Capitalism Editorial Team

Fast Capitalism

No abstract provided.

Have A Heart For The Holocene: The Politics Of Ark Activism, Collaborative Conservation, And Sponsored Survival At Museums, Timothy W. Luke

Fast Capitalism

No abstract provided.