Digital Commons Network^™

Downregulation Of Slc40a1 Leads To Iron Accumulation In Fibrotic Lung Fibroblasts, Quanjin Dang, Chaoqun Huang, Yurong Liang, Akshaya Surendran, Dharanya Muthiah, Kishore Vaddadi, Sankha Hewawasam, Tingting W Mills, Lin Liu

Faculty, Staff and Student Publications

Iron is an essential nutrient for almost all organisms. However, excess iron generates reactive oxygen species and causes tissue injuries. Iron is implicated in idiopathic pulmonary fibrosis (IPF). In this study, we examined iron accumulation in fibrotic lung fibroblasts and the underlying mechanisms. We hypothesize that the downregulation of Solute Carrier Family 40 Member 1 (SLC40A1) results in iron accumulation in lung fibroblasts of IPF patients. Using a Prussian Blue iron staining, we found that iron accumulated in the fibrotic region of the lungs from IPF patients and bleomycin- and asbestos-induced lung fibrosis mice. Iron was partially co-localized with the …

An Application-Based Ontological Knowledge Base Of Medications To Support Health Literacy And Adherence For The Consumer Population: An Aging Population Use Case, Clifford Chen, Muhammad Amith, Kirk Roberts, Rebecca Mauldin, Renata Komalasari, Cui Tao

Faculty, Staff and Student Publications

No abstract provided.

The Origin Of Hepatocellular Carcinoma Depends On Metabolic Zonation, Jason Guo, Roger Liang, Andrew Chung, Zhijie Li, Boyuan Li, Eric Chen, Lin Li, Jingjing Wang, Meng-Hsiung Hsieh, Ivy Xiangyi Fang, Benjamin Kroger, Yunguan Wang, Min Zhu, Xiongzhao Ren, Greg Mannino, Yuemeng Jia, Yonglong Wei, Stephen Moore, Daniel J Siegwart, Stephen S Chung, Zixi Wang, Tripti Sharma, Suman Komjeti, Yi Han, Purva Gopal, Guanghua Xiao, Tao Wang, Hao Zhu

Faculty, Staff and Student Publications

The origin of cancer is poorly understood because premalignant cells are rarely followed in their native environments. Although the spatial compartmentalization of metabolic functions is critical for proper liver function, it is unknown whether cancers arise from some zones but not others and whether there are metabolic determinants of cancer risk. Zone-specific, mosaic introduction of Ctnnb1 (catenin beta 1) and Arid2 (AT-rich interaction domain 2) mutations, commonly co-mutated genes in hepatocellular carcinoma (HCC), in mouse models showed that position and metabolic context determine clone fates. Ctnnb1/Arid2-driven cancers were much more likely to arise in zone 3. The …

Quaker Campus, January 29, 2026 (Vol. 24, Issue 7), Whittier College

Quaker Campus

No abstract provided.

2026-01-29 Faculty Senate Meeting Minutes, Morehead State University. Faculty Senate.

Faculty Senate Records

Faculty Senate meeting minutes from January 29, 2026.

2026-01-29 Faculty Senate Newsletter, Morehead State University. Faculty Senate.

Faculty Senate Records

Faculty Senate newsletter from January 29, 2026.

Artificial Intelligence In Higher Education, Opportunities, And Challenges: A Review, Sharifa Alblooshi

All Works

Artificial intelligence (AI) is a growing force of change in higher education, providing assistance to students, teachers, and administrators in teaching, learning, and administration. As AI technologies advance rapidly, they present a combination of significant opportunities and complex challenges. In this study, we examine the role of AI in higher education, highlighting both its positive and negative impacts, as well as current policy gaps and issues arising from its deployment. The literature on the topic was reviewed to determine how AI decisively impacts teaching and learning, the role of AI in assessments and academic integrity, as well as ethics, psychological …

European Ai Fomo: The European Commission Sacrifices The Digital Acquis At The Altar Of Ai Hype, Felix Bieker, Katherine Nolan

Research Outputs: 2025-Present

No abstract provided.

Dhodh Links Mitochondrial Bioenergetics, One-Carbon Metabolism, And Dna Repair To Sustain Aggressive Prostate Adenocarcinoma, Saiswaroop Rajaratnam, Danthasinghe Waduge Badrajee Piyarathna, Ranjit K Mehta, Venugopalareddy Mekala, Jun Hyoung Park, Uttam Rasaily, Vani Venkatappa, Karthik Reddy Kami Reddy, Vasanta Putluri, Kaveri Goel, Sandra L Grimm, Sai Manohar Thota, Taylor Morrison, Cristian Coarfa, Benny Abraham Kaipparettu, Chao Cheng, Nagireddy Putluri, Jeffrey A Jones, Mukesh K Nyati, Michael Ittmann, Natalie R Gassman, Arun Sreekumar

Faculty, Staff and Students Publications

Background

Dihydroorotate dehydrogenase (DHODH) is a mitochondrial enzyme that connects de novo pyrimidine biosynthesis with the electron transport chain (ETC) function. However, its broader role in prostate cancer (PCa) signaling and response to therapy remains unclear.

Methods

We combined transcriptomic, metabolomic, epigenomic, and functional analyses with clinical outcome data to explore the effects of DHODH depletion in ancestry-annotated European American (EA) and African American (AA) prostate cancer cell line models.

Results

DHODH was markedly overexpressed in malignant prostate epithelial cells and was abundant in tumors. Its knockdown hindered cell proliferation by causing pyrimidine depletion, while unexpectedly increasing oxidative phosphorylation, ETC …

January 29, 2026, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Use Of Electrocardiograms To Identify Coronary Artery Disease: Cross-Validation Of An Artificial Intelligence Model, Michael Leasure, Indu Poornima, Adam Butchy, Utkars Jain, Devin Vasoya, Michael Warnick, Brent Williams, John Rehder, Prahlad Menon, Veronica A. Covalesky, Gary S. Mintz

Department of Medicine Faculty Papers

BACKGROUND: The current gold standard for the diagnosis of coronary artery disease (CAD) is invasive angiography; however, it is an invasive procedure. Therefore, we developed an artificial intelligence model designed to predict significant CAD from a resting digital 12-lead electrocardiogram (ECG).

OBJECTIVES: This retrospective study assessed the model's ability to predict clinically significant CAD in a patient population presenting for coronary angiography.

METHODS: From 2019 to 2021, 16,476 patients had a resting 12-lead digital ECG recorded within 90 days prior to coronary angiography. The artificial intelligence model was developed using 10-fold cross-validation methodology. Clinically significant disease was defined as angiographic …

Analysis Of Active Ingredients In Medicinal Herbs With High-Performance Liquid Chromatography And Related Technologies: A Review, T.-H. Tsai, C.-Y. Hong, C.-F. Chen

Journal of Food and Drug Analysis

An increasing number of analytical techniques have been brought to bear on the herbal drugs used in traditional Chinese medicine. This in turn has led to improved quality control of medicinal herbs, ingredient stability and shelf-life tests, ensurement of the concentrations of herbal drug ingredients in biological fluids, and pharmacokinetic studies. In the past decades, gas chromatography has been the method of choice for the analysis of volatile compounds, while liquid chromatography is a highly successful separation technique for nonvolatile molecules. Recently, high-performance liquid chromatography coupled with various column and detection systems have become some of the most important techniques …

A Strengths, Weaknesses, Opportunities, And Threats (Swot) Analysis Of Chatgpt In Academic Help-Seeking, Fan Yang

International Journal of Teaching and Learning in Higher Education

This study explores the use of ChatGPT as a help-seeking tool in educational contexts, examining both its potential benefits and costs through a SWOT (Strengths, Weaknesses, Opportunities, and Threats) analysis. The purpose is to provide a comprehensive understanding of the various internal and external factors that either promote or hinder the use of ChatGPT for academic help-seeking. The strengths of ChatGPT, such as its 24/7 availability to provide immediate responses, non-judgmental tone, and the ability to provide personalized help based on specific prompts, position itself as a valuable resource for help-seekers. However, the low quality of the responses generated by …

Review Of Moravian Women’S Memoirs: Their Related Lives, 1750-1820, Marlyn Mcgary Klee

Communal Societies

No abstract provided.

Just To Breathe: Personal Recollections Of Synanon Founder Chuck Dederich, Ellen Broslovsky

Communal Societies

No abstract provided.

The Commune That Didn’T Come To Town: The Love Israel Family And A Small Town In Idaho, Charles P. Lewarne

Communal Societies

No abstract provided.

“I Am, Dear Sir, Your Grateful Disciple, Margaret Chappellsmith.”, Clark Kimberling

Communal Societies

No abstract provided.

Regional Differences In The Size And Composition Of Communal Membership: The Shakers, 1850-1870, Bradley B. Andrew, Metin M. Cosgel

Communal Societies

No abstract provided.

Seizing The "Organic" Moment: Cuba's Agricultural Crossroads And Certified Organic Export Potential, Wesley J. Hevia, Michael T. Olexa, Thomas T. Ankersen, William A. Messina Jr.

Florida Journal of International Law

Cuba has been referred to as "the world's first national experiment in sustainable agriculture." Given the critical shortages in chemical inputs to Cuba's agricultural sector following the loss of Soviet economic support and subsidization, this may well be a fitting description. Cuba's use of the term "organic" to describe some of its agricultural production can be misleading. Not all of Cuba's "organic" products would satisfy the organic certification requirements for most developed countries. That being said, Cuba is shipping certified organic fresh citrus and citrus juices into EU markets. With proper investments and implementation of the appropriate procedures and protocols, …

Exploring Cuba's New Role In The World Economy: Paths And Perils, Wentong Zheng

Florida Journal of International Law

With the normalization of relations with the United States and other countries, Cuba is ushering in a new era with unprecedented opportunities in a globalized world. Participating in the world economy, however, is a risky proposition. It requires policymakers to carefully weigh the pros and cons of each development path and choose the one that best suits Cuba. It also requires policymakers to be prepared for the perils, both economic and legal, that may arise from Cuba's participation in the world economy. This Article explores Cuba's new role in the world economy and the perils that accompany this new role. …

State Capitalism In Cuba: The Lessons Of The Literature On State Owned Enterprises And Market Liberalization, D. Daniel Sokol

Florida Journal of International Law

This Article outlines core concerns for Cuba in its market liberalization process. First, from the agency cost perspective, it explores the limitations of state owned enterprises (SOEs) versus private (publicly traded) firms. Then, it examines the empirical literature on SOEs and SOE reforms and privatizations. Next, the Article offers a number of possible policies going forward that will allow Cuba to reform its state capitalism to benefit Cuba's consumers. Such reforms include SOE corporatization, SOE privatization, and the introduction of a competition policy system to Cuba (as effective corporate governance and competition may be substitutes for each other).

U.S.-Cuba Trade And The Challenge Of Diversifying A Sugar Economy, 1902-1962, Carmen Diana Deere

Florida Journal of International Law

This Article gives a detailed analysis of Cuba's non-sugar and tobacco exports (NST) to the United States, focusing on the development of non-traditional exports of fruits and vegetables.

Food Security, Industrialized Agriculture, And A Changing Global Climate: Perspectives On The United States And Cuba, Mary Jane Angelo

Florida Journal of International Law

This Article outlines the challenges of feeding a growing population in a time of climate change and in the shadow of the risks presented by industrialized agriculture. Part II presents an overview of current food insecurity and explores the likely exacerbation that will result from the impacts of climate change. Part III compares the evolution of agricultural systems in the United States and Cuba. This part also examines the environmental harms caused by industrialized agriculture in the United States and the limited protection offered by U.S. environmental law to protect against these harms. This part then turns to the evolution …

Agricultural Policy And Rural Development In Cuba, The Public Agriculture Section, Maritza De La Caridad Mc Cormack Bequer

Florida Journal of International Law

No abstract provided.

Environmental Legislation And Institutional Framework In Cuba, Daimar Cánovas González

Florida Journal of International Law

No abstract provided.

General Overview Of Cuban Family Law Legislation, Ana María Álvarez-Tabío Albo

Florida Journal of International Law

This Essay will take four routes that converge at multiple points. First, we will review the social context prevailing when the Family Code (Código de Familia) was promulgated on March 8, 1975, coinciding with International Women's Day. Afterwards, we will briefly refer to other pieces of legislation that complete the universe of judicial ordinances protecting the family. Next, we will dedicate more time to examining the fundamental characteristics of the principal institutions of Cuban Family Law. Finally, we will see the challenges that must be confronted in the prevailing reality in the Cuban family and society.

Instruments Of Environmental Governance: A Guarantee Of Substainability In Cuba, Dagniselys Toledano Cordero

Florida Journal of International Law

No abstract provided.

Review Of “The Pursuit Of A Dream”, Luther E. Smith Jr.

Communal Societies

No abstract provided.

Group Conformity And The Amplification Of Deviance: A Comparison Of Hutterite And Mormon Dress Codes, Bron B. Ingoldsby

Communal Societies

No abstract provided.

Between Zion And Babylon. The Application Of The Total Institution Model To A Christian Charismatic Community: The Case Of The Jesus Fellowship, Stephen Hunt

Communal Societies

No abstract provided.