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Articles 35041 - 35070 of 1791783
Full-Text Articles in Entire DC Network
Italian Medical Students' Knowledge, Attitudes And Beliefs About Medical Marijuana And Their Implications On The Italian Medical Curriculum, Sneh S. Shah, Roberta Pastorino, Phd, Giovanni Gambassi, Md
Italian Medical Students' Knowledge, Attitudes And Beliefs About Medical Marijuana And Their Implications On The Italian Medical Curriculum, Sneh S. Shah, Roberta Pastorino, Phd, Giovanni Gambassi, Md
Alpha Omega Alpha Research Symposium Posters
Purpose: Medical marijuana is gaining clinical and legislative relevance in Italy, yet little is known about Italian medical students’ knowledge, attitudes, and preparedness regarding its therapeutic use. As future physicians, medical students will play a key role in integrating cannabis-based therapies safely into patient care. This study assessed Italian medical students’ perceived knowledge, clinical exposure, and attitudes toward medical marijuana, and evaluated implications for the medical curriculum.
Methods: A cross-sectional, anonymous online survey was distributed to students across Italian medical universities from May 2023 to March 2024. The survey used Likert-scale items to assess attitudes, perceived knowledge, educational exposure, and …
Increasing Physical Activity In Moderate-Severe Traumatic Brain Injury: Protocol For A Two-Stage Randomized Controlled Trial Of A Remote, Mhealth-Enhanced Intervention, Tessa Hart, Monica Vaccaro, Lauren Krasucki, Inna Chervoneva, Amanda Rabinowitz
Increasing Physical Activity In Moderate-Severe Traumatic Brain Injury: Protocol For A Two-Stage Randomized Controlled Trial Of A Remote, Mhealth-Enhanced Intervention, Tessa Hart, Monica Vaccaro, Lauren Krasucki, Inna Chervoneva, Amanda Rabinowitz
Moss-Magee Rehabilitation Papers
OBJECTIVE: Protocol for randomized controlled trial (RCT) examining effects of novel, remotely delivered intervention (called GetUp&Go) to increase physical activity (PA) in chronic, moderate-severe traumatic brain injury (msTBI), including a mobile health (mHealth) component.
DESIGN: RCT (Clinicaltrials.gov NCT06028334) with 1:1 randomization to 10 weeks of immediate treatment (IT) or waitlist (WL), with primary outcome measured at 10 weeks. A second randomization to 10 weeks of continued mHealth support vs. no treatment will allow for examination of effects of mHealth on maintenance of treatment gains.
PARTICIPANTS: 70 community-dwelling adults ≥6 months post msTBI; medically cleared and physically/ cognitively able to participate; …
Employment Research, Vol. 33, No. 1, January 2026
Employment Research, Vol. 33, No. 1, January 2026
Employment Research Newsletter
No abstract provided.
Sherice Sargent V. School District Of Philadelphia
Sherice Sargent V. School District Of Philadelphia
2026 Decisions
USDC for the Eastern District of Pennsylvania
Pacific Rxtracts - February 2026, Pacific Rxtracts
Pacific Rxtracts - February 2026, Pacific Rxtracts
Pacific RxTracts
Articles:
- Reducing Proteinuria – FDA Accelerates Approval of Sibeprenlimab
- FDA Approves Oral Semaglutide as First GLP-1 Pill for Weight Loss
- New First-Line Digital Treatment for Generalized Anxiety Disorder
- Ammoxetine: A Potential New Antidepressant For Major Depressive
- Extended-Release Buprenorphine Dosing in Individuals With High-Risk Opioid Use
- Managing Acute Agitation Without Injections: Oral Medications in the ED
- Prescription Stimulant Continuation in Pregnancy and Birth Outcomes
- Zoliflodacin - A New Treatment For Gonorrhea
- Intranasal Dexmedetomidine for Postoperative Sleep Quality After Gynecologic Laparoscopy
- FDA Approves Depemokimab, the First Twice-Yearly Biologic for Severe Eosinophilic Asthma Cancer Care
- Engineering Allogeneic CD7-Targeted CAR-T Cells Through Targeted Base …
Intouch Week Of February 2, 2026, New York Medical College
Intouch Week Of February 2, 2026, New York Medical College
InTouch
- Campus Illumination and Panel Discussion Honors Holocaust Remembrance Day
- Where Experience Becomes Evidence: Advancing Transplant Education at NYMC
- D.P.T. Student Experience
- Love at NYMC
Lgbtqiapn+ Leadership: Barriers And Challenges In Organizational Work Relations, Luiz Henrique Gardini De Silva, Emerald Jay D. Ilac, Tatiani Schmitt
Lgbtqiapn+ Leadership: Barriers And Challenges In Organizational Work Relations, Luiz Henrique Gardini De Silva, Emerald Jay D. Ilac, Tatiani Schmitt
Leadership and Strategy Faculty Publications
To identify the main barriers and challenges faced by LGBTQIAPN+ leaders in the workplace and examine their relationships with leadership self-efficacy. Methodology: Data collection involved LGBTQIAPN+ individuals in leadership positions, resulting in responses from 1,156 participants. To test the proposed theoretical model, Structural Equation Modeling analysis was performed. Main results: The findings highlighted issues related to group composition and diversity in sexual orientation and gender identity as the main barriers and challenges. The validation of the hypotheses supported the notion that the difficulties experienced by LGBTQIAPN+ individuals at work can provide them with valuable skills that lead to leadership, making …
Abandoned Priorities And Cases In Limbo: An Analysis Of Title Ix Enforcement In The First Year Of Trump’S Second Term, Jessica Lee, Westley Shaw
Abandoned Priorities And Cases In Limbo: An Analysis Of Title Ix Enforcement In The First Year Of Trump’S Second Term, Jessica Lee, Westley Shaw
Center for WorkLife Law
During President Trump’s second term, the Department of Education’s Office for Civil Rights has resolved far fewer cases than his first term or the ten year average, and has not resolved a single case of discrimination based on sexual assault, sexual harassment, or pregnancy/parental status.
Faculty Senate Minutes February 2, 2026, Utah State University
Faculty Senate Minutes February 2, 2026, Utah State University
Faculty Senate & Faculty Senate Executive Committee
- Call to Order
- University Business
- Faculty Senate Business
- Reports
- School of Graduate Studies
- Professional Responsibilities and Procedures Committee (PRPC)
- Office of Research
- Old Business
- New Business
- Information
- Adjourn - 4:43 pm
Residual Jim Crow Ideals And Healthcare For Black Women, Keion Daniels
Residual Jim Crow Ideals And Healthcare For Black Women, Keion Daniels
Father Jack McGrath, S.M., Research Award Presentations
Keion Daniels is a recipient of the 2026 Father Jack McGrath, S.M., Award for Research in Catholic Intellectual Traditions.
Experiences Of Stigma And Barriers To Care Among Transgender And Gender Expansive Populations Seeking Mental Healthcare, Amanda Veldorale-Griffin, Elizabeth Banks, Elizabeth Patrick, Judith Cannon, Caidan Thomas Smith
Experiences Of Stigma And Barriers To Care Among Transgender And Gender Expansive Populations Seeking Mental Healthcare, Amanda Veldorale-Griffin, Elizabeth Banks, Elizabeth Patrick, Judith Cannon, Caidan Thomas Smith
Marriage and Family Therapy Faculty Articles and Research
Transgender and gender expansive (TGGE) people experience increased risk for mental health issues and suicidality, as well as significant barriers to mental healthcare, due to stigma and discrimination, including from mental healthcare providers. A sample of 945 TGGE participants completed self-report surveys, measuring experiences of stigma and barriers to care, and counselor competence. Data were divided into two groups by age and analyzed through linear regressions and one-way ANOVAs. Across groups, participants (approximately 58% of younger participants and 49% of older participants) reported experiencing stigma from a healthcare provider, and all reported some barriers to care, with more than half …
Health Mentor Perspectives On (In)Effective Healthcare Teams: Insights To Inform Care Coordination For Chronically Ill Populations, Arianna Baffa, Kelly Tran, Jane Tobias, Dnp, Crnp-Pc, Nethra S. Ankam, Md, Maria Brucato, Phd
Health Mentor Perspectives On (In)Effective Healthcare Teams: Insights To Inform Care Coordination For Chronically Ill Populations, Arianna Baffa, Kelly Tran, Jane Tobias, Dnp, Crnp-Pc, Nethra S. Ankam, Md, Maria Brucato, Phd
Phase 1
Background
- Disability and chronic illness are a major public health burden in the US
- More than a quarter of Americans report a functional disability1
- ~129 million Americans have at least one major chronic disease2
- Interprofessional teamwork and coordination of care have potential to support the quintuple aim of healthcare3
- Patients with multiple chronic conditions and lower confidence in managing their own health experience more care coordination challenges4
- Patient perspectives are needed to improve healthcare services for chronically ill populations, but limited awareness of team approaches in care presents a methodological challenge to …
Critical Student Agency In An Integrated Social Studies Unit, Bolaji Bamidele, Kristin A. Searle
Critical Student Agency In An Integrated Social Studies Unit, Bolaji Bamidele, Kristin A. Searle
Instructional Technology and Learning Sciences Student Research
Background: Research has highlighted the value of centering student voices and agency in classroom contexts, yet few curricula explicitly foreground critical agency in their design. This qualitative case study examines how students enact agency within an integrated curriculum that combines computer science, social studies, and Indian Education for All (IEFA) standards. The unit focused on tribal sovereignty and why treaties still matter for indigenous people today, enabling students to connect their lived experiences to broader sociopolitical contexts. Data were collected through classroom observations, student and teacher interviews, and student artifacts. Results: Analysis revealed that students performed agency in three interrelated …
Graduate Council Minutes 2026-02-02, Northern Illinois University
Graduate Council Minutes 2026-02-02, Northern Illinois University
Graduate Council Archives
No abstract provided.
Designing A Multilingual Instructional Language Tool For Patient Communication In Interventional Radiology, Samuel Almodóvar, Ahlam Houssein, Gregg Khodorov, Md, Mba, Sahib Sohal, Md, Robert Pugliese, Pharmd, David Dwyer, Md
Designing A Multilingual Instructional Language Tool For Patient Communication In Interventional Radiology, Samuel Almodóvar, Ahlam Houssein, Gregg Khodorov, Md, Mba, Sahib Sohal, Md, Robert Pugliese, Pharmd, David Dwyer, Md
Alpha Omega Alpha Research Symposium Posters
Introduction: Current efforts to provide language-inclusive radiological care fall short, resulting in suboptimal imaging, increased procedural time, and greater radiation exposure. Inadequate language accessibility results in poor communication, suboptimal care, and increased patient dissatisfaction. A digital language tool was developed to provide patient instructions during interventional radiology (IR) procedures, addressing this gap and enhancing patient care.
Methods: Observations were carried out to better understand workflow during IR procedures and identify how to incorporate the tool. We conducted interviews with IR physicians, nurses, and technologists to gather common procedural phrases and patient instructions. Spanish and Mandarin were selected because they are …
Exploring Physician Views On Birth Method And Route Of Delivery, Vivian Nguyen, Vincenzo Berghella, Md
Exploring Physician Views On Birth Method And Route Of Delivery, Vivian Nguyen, Vincenzo Berghella, Md
Alpha Omega Alpha Research Symposium Posters
Purpose: In the United States, rates of cesarean deliveries (CD) have been increasing. Despite recommendations from the American College of Obstetrics and Gynecology to prevent increasing rates of CDs, planned CD has been associated with lower rates of perinatal deaths and better maternal outcomes when compared to planned vaginal delivery (VD). However, the data is limited, so it is important that we conduct randomized controlled trials (RCTs) comparing maternal and perinatal outcomes in planned CD vs planned vaginal delivery (VD) for nulliparous, term, single, vertex pregnancies. The purpose of study is to survey obstetricians and gynecologists (ob/gyns) on their …
Medicine During The Holocaust: A Comparative Study Of Righteous Dutch, German, And Italian Physicians, Vincent Tse, Salvatore Mangione
Medicine During The Holocaust: A Comparative Study Of Righteous Dutch, German, And Italian Physicians, Vincent Tse, Salvatore Mangione
Alpha Omega Alpha Research Symposium Posters
Purpose: Authoritarianism can hinder altruism, even among physicians, the most altruistic members of society. Hence, we postulated that the proportion of doctors who saved Jews during the Holocaust (i.e. “Righteous Among the Nations”) was higher in a democratic country like the Netherlands as compared to authoritarian ones like Germany and Italy.
Methods: We analyzed the Yad Vashem database and other census data to determine the total populations, numbers of physicians, numbers of “Righteous”, and numbers of “Righteous” physicians in Germany, Italy, and the Netherlands during WWII. A chi-squared analysis for independence evaluated the association between proportion of “Righteous” physicians to …
Exercise Performance In Ordinary Children And Adolescents: Baseline, Pandemic, And Post-Pandemic, Abby Skiena, Gina D'Aloisio, Ms, Takeshi Tsuda, Md
Exercise Performance In Ordinary Children And Adolescents: Baseline, Pandemic, And Post-Pandemic, Abby Skiena, Gina D'Aloisio, Ms, Takeshi Tsuda, Md
Alpha Omega Alpha Research Symposium Posters
Background: The COVID-19 pandemic might have created considerable negative impacts on the physical fitness of ordinary adolescents, which may pose a major threat to long-term cardiovascular health.
Methods: Healthy adolescents (ages 11 to 18) who underwent cardiopulmonary exercise testing (CPET) were grouped into baseline (~ 3/2020), pandemic (4/2020 ~12/2022), and post-pandemic (1/2023~ 5/2024) periods. Data are shown as mean ± standard deviation.
Results: Peak oxygen consumption (VO2/kg) and peak work rate (WR/kg) were significantly reduced during pandemic in both sexes and did not improve during post-pandemic in males (Table 1). The decline of peak oxygen pulse (OP/kg) …
Characterizing The Effects Of Antimuscarinics On Rhoa Signaling, Zuhra Tukhtamisheva, Elizabeth L. Mcduffie, Jordan Lee, Steven S. An, Reynold A. Panettieri Jr., Charles Scott
Characterizing The Effects Of Antimuscarinics On Rhoa Signaling, Zuhra Tukhtamisheva, Elizabeth L. Mcduffie, Jordan Lee, Steven S. An, Reynold A. Panettieri Jr., Charles Scott
Alpha Omega Alpha Research Symposium Posters
Purpose: Airway hyperresponsiveness in asthma is driven by acetylcholine-mediated activation of the muscarinic acetylcholine 3 receptor (M3R), promoting bronchoconstriction, mucus hypersecretion, and airway remodeling. Despite directly targeting this pathway, antimuscarinics remain adjunctive rather than first-line therapy, suggesting a disconnect between biological rationale and clinical efficacy. Recent work from the Scott Lab at Thomas Jefferson University demonstrates that M3R in human airway smooth muscle (HASM) cells drives muscle shortening through G12/13–driven RhoA signaling rather than through Gq/11-dependent calcium flux. We therefore investigated whether clinically prescribed antimuscarinics effectively inhibit G12/13-dependent RhoA signaling in HASM cells.
Methods: …
Interrelationship Between Body Mass Index, Venous Sinus Pressures, Craniospinal Elastance, And Intracranial Pressure In Idiopathic Intracranial Hypertension, Rachel Wang, Ba, Bs, Scott W. Keith, Phd, Pascal M. Jabbour, Md, Stavropoula I. Tjoumakaris, Md, Michael J. Marmura, Md, Michael R. Gooch, Md, Hsiangkuo Yuan, Md, Phd
Interrelationship Between Body Mass Index, Venous Sinus Pressures, Craniospinal Elastance, And Intracranial Pressure In Idiopathic Intracranial Hypertension, Rachel Wang, Ba, Bs, Scott W. Keith, Phd, Pascal M. Jabbour, Md, Stavropoula I. Tjoumakaris, Md, Michael J. Marmura, Md, Michael R. Gooch, Md, Hsiangkuo Yuan, Md, Phd
Alpha Omega Alpha Research Symposium Posters
Purpose: To investigate the interrelationship between body mass index (BMI), venous sinus pressure (VSP), and craniospinal elastance in determining lumbar puncture opening pressure (LP OP) in idiopathic intracranial hypertension (IIH).
Methods: A single-center retrospective chart review was conducted to identify patients who received venous manometry (8/2021-11/2025) followed by LP within 7 days before stenting. VSPs were measured at standardized locations, including the torcula (TP) and sigmoid/jugular (SIJ) sinuses. Elastance was calculated as (OP – closing pressure)/volume of CSF removed. Statistical analysis (JASP 0.19.3) was performed using generalized linear model (Gaussian identity; scaled center) to assess relationships between LP OP, BMI, …
Comparative Analysis Of Fsrt And Srs For Vestibular Schwannoma Using A Large Multi-Institutional Dataset, Ian Argento, Bs, Daniel Uralov, Md, Jacob Beiriger, Md, Anika Walia, Bs, Kalena Liu, Bs, Wenyin Shi, Md, Jacob B. Hunter, Md
Comparative Analysis Of Fsrt And Srs For Vestibular Schwannoma Using A Large Multi-Institutional Dataset, Ian Argento, Bs, Daniel Uralov, Md, Jacob Beiriger, Md, Anika Walia, Bs, Kalena Liu, Bs, Wenyin Shi, Md, Jacob B. Hunter, Md
Alpha Omega Alpha Research Symposium Posters
Purpose: Stereotactic radiosurgery (SRS) and fractionated stereotactic radiotherapy (FSRT) both achieve high control rates of vestibular schwannomas (VS), but their comparative effects on functional outcomes remain uncertain. Prior studies are limited by small sample sizes and heterogeneous methods.
Methods: Deidentified data were analyzed from 100 healthcare organizations through TriNetX. Adults with VS (ICD-10: D33.3) and sensorineural hearing loss (H90.A/H90.1–H90.8) were included. Patients with neurofibromatosis or prior surgical resection were excluded. Treatment cohorts consisted of single-session SRS or ≥2-sessions of FSRT. Propensity score matching (1:1) yielded 909 patients per cohort. Outcomes—including hearing loss, cerebral edema, hydrocephalus, and cranial nerve …
Assessing Familiarity And Comfortability Of Phase 2 Skmc Students In Working With The Intellectually Disabled Population, Lily N. Dudash, Jessica Tomaszewski, Md, Talia Gillespie, Katie Labgold, Phd, Mph
Assessing Familiarity And Comfortability Of Phase 2 Skmc Students In Working With The Intellectually Disabled Population, Lily N. Dudash, Jessica Tomaszewski, Md, Talia Gillespie, Katie Labgold, Phd, Mph
Alpha Omega Alpha Research Symposium Posters
Purpose: People living with an intellectual or developmental disability (IDD) are at increased risk of poor health outcomes due to inadequate access to quality healthcare. Literature suggests that trainees are underprepared to adjust their clinical practice to treat these patients, which may implicate undergraduate medical education curriculum. This study assessed the comfortability of SKMC students who have completed Phase 2 of the JeffMD curriculum in performing clinical tasks while caring for patients with IDD, and if that comfort is affected by prior experience. We predict that students will report low levels of comfort and be engaged in an educational intervention. …
The Impact Of Neighborhood Socioeconomic Factors And Insurance Status On Outcomes Following Reduction Mammoplasty, Teresa Chan, Kelsey Van Housen, Mspas, Emily Isch, Md, Judith Monzy, Julianne Bartz, Matthew Jekins, Md, David Kim, Md, Andrew Newsman, Md, Heather Mcmahon, Md
The Impact Of Neighborhood Socioeconomic Factors And Insurance Status On Outcomes Following Reduction Mammoplasty, Teresa Chan, Kelsey Van Housen, Mspas, Emily Isch, Md, Judith Monzy, Julianne Bartz, Matthew Jekins, Md, David Kim, Md, Andrew Newsman, Md, Heather Mcmahon, Md
Alpha Omega Alpha Research Symposium Posters
Purpose: The impact of socioeconomic status (SES) and neighborhood-level deprivation on surgical outcomes in breast reduction remains unclear. This study evaluated the effect of area deprivation index (ADI) and insurance status on postoperative outcomes following reduction mammoplasty.
Methods: A retrospective review of reduction mammoplasty cases was conducted at a single institution over a 7-year period. Patients ≥18 years old who underwent reduction mammoplasty for benign macromastia were included. Zip-code linked ADI, insurance type, and postoperative complication rate were assessed.
Results: A total of 594 patients were analyzed. Mean age was 36.2 ± 13.1 years and mean body mass index (BMI) …
Neck Circumference As A Novel Predictor Of Cardiovascular Risk Assessed Using Framingham And Prevent Equations, Stephen Garrova, Roshaan Gilani, Steven Muller, Jean Pierre Charpentier, Brian Fedgchin, Glenn Cooper, Cindy Cheng
Neck Circumference As A Novel Predictor Of Cardiovascular Risk Assessed Using Framingham And Prevent Equations, Stephen Garrova, Roshaan Gilani, Steven Muller, Jean Pierre Charpentier, Brian Fedgchin, Glenn Cooper, Cindy Cheng
Alpha Omega Alpha Research Symposium Posters
Purpose: While body mass index (BMI) and waist circumference (WC) are standard clinical tools for anthropometric cardiovascular risk assessment, they are limited by measurement variability and patient discomfort. Neck circumference (NC) may offer a novel, convenient, and accurate alternative anthropometric measure for assessment of cardiovascular risk.
Methods: Standardized anthropometric measurements (NC, WC, BMI) were obtained by trained medical students from eligible patients (n = 110, 68% female, 75% African American) from primary care and cardiology offices in an IRB-approved cohort study with retrospective chart review. Electronic medical record data extraction via double data entry was used to calculate cardiovascular …
Jefferson Heart Health (Jhh): A Successful Student-Delivered Motivational Interviewing Pilot Program To Lower Cardiovascular Disease (Cvd) Risk, Nicholas Tomasko, Bs, Cindy Cheng, Md, Phd, Rafael Hernandez, Bs, Alessandra Sapon, Bs
Jefferson Heart Health (Jhh): A Successful Student-Delivered Motivational Interviewing Pilot Program To Lower Cardiovascular Disease (Cvd) Risk, Nicholas Tomasko, Bs, Cindy Cheng, Md, Phd, Rafael Hernandez, Bs, Alessandra Sapon, Bs
Alpha Omega Alpha Research Symposium Posters
Purpose: The Jefferson Heart Health (JHH) program utilizes student health coaching by trained undergraduate and medical students supporting patients to sustain lifestyle changes and subsequently determine: how can we effectively educate patients by improving adherence to lifestyle recommendations? Also, what is the effectiveness of student-delivered health coaching for reducing patient cardiovascular risk? With our unique student-delivered program, we promote cost-effective lifestyle interventions for lowering overall cardiovascular disease (CVD) burden.
Methods: We successfully completed a four-week pilot with consistent patient attendance. Certified student JHH coaches, supervised by the certified obesity-management specialist and principal investigator, met weekly with 23 patients: 82.6% female/17.4% …
Systematic Evaluation Of Batch Effects In The Cancer Genome Atlas Program Underscores The Need For Batch-Controlled Analysis, Zhongxuan Chen, Stepan Nersisyan, Isidore Rigoutsos, Eric Londin
Systematic Evaluation Of Batch Effects In The Cancer Genome Atlas Program Underscores The Need For Batch-Controlled Analysis, Zhongxuan Chen, Stepan Nersisyan, Isidore Rigoutsos, Eric Londin
Alpha Omega Alpha Research Symposium Posters
Purpose: To systematically assess the impact of batch effects on differential expression of isomiR, mRNA, and non-coding RNA (sncRNA) across 13 The Cancer Genome Atlas (TCGA) cancer types and develop a standardized, batch-controlled analysis protocol for TCGA datasets.
Methods: Data analysis and visualization were performed using Python v3.12. Plots were generated using matplotlib and seaborn. isomiR, mRNA, and sncRNA sequences across 13 TCGA cancer types were used. Principal Component Analysis (PCA) was performed using scikit-learn for dimensionality reduction. Differential expression was conducted using DESeq2 under the following protocols: 1) primary tumor samples vs matched normal samples processed in the same …
Elucidating The Binding Site Of The Arrestin-Biased Agonist Icl1-20, Kesara Wein, Roger Armen, Jeffrey L. Benovic, Charles P. Scott
Elucidating The Binding Site Of The Arrestin-Biased Agonist Icl1-20, Kesara Wein, Roger Armen, Jeffrey L. Benovic, Charles P. Scott
Alpha Omega Alpha Research Symposium Posters
Background and Purpose: 6.7 million Americans live with congestive heart failure (CHF). In CHF, catecholamines are released into cardiac tissue, bind β-adrenergic receptors (βARs), and activate G-protein signaling cascades, causing ischemia and apoptosis. Accordingly, β-blockers are used to antagonize catecholamine binding to βARs and suppress apoptotic downstream effects. However, β-blockers have dose-limiting hypotension, bradycardia and fail to stimulate the cardioprotective β-arrestin signaling pathway. These limits create opportunities for the development of drugs that selectively stimulate β-arrestin signaling while suppressing cardiotoxic G protein signaling. We have previously reported a biased agonist of the β-arrestin pathway (ICL1-20) that selectively stimulates β-arrestin recruitment …
Survival Impact Of Intraoperative Co2 Dysregulation In Patients Undergoing Pancreaticoduodenectomy For Pancreatic Ductal Adenocarcinoma, Ashley Wetzel, Andrea Feci, Joseph Gorman, Isabel Lavine, Edoardo Manca, Richard Zheng, Md, Nader Hanna, Md, Harish Lavu, Md, Charles J. Yeo, Md, Avinoam Nevler, Md
Survival Impact Of Intraoperative Co2 Dysregulation In Patients Undergoing Pancreaticoduodenectomy For Pancreatic Ductal Adenocarcinoma, Ashley Wetzel, Andrea Feci, Joseph Gorman, Isabel Lavine, Edoardo Manca, Richard Zheng, Md, Nader Hanna, Md, Harish Lavu, Md, Charles J. Yeo, Md, Avinoam Nevler, Md
Alpha Omega Alpha Research Symposium Posters
Purpose: Pancreatic ductal adenocarcinomas (PDAC) are aggressive malignancies with poor prognoses. Emerging evidence suggests tissue hypercapnia (elevated CO2) promotes aggressive, treatment resistant tumor biology. End-tidal CO2 (ETCO2) offers a composite measure of ventilation, systemic perfusion, and tissue CO2 production. During curative-intent pancreaticoduodenectomy, we hypothesized that intraoperative ETCO2 could serve as a marker of tissue CO2 dyscapnia; both low levels indicating decreased circulatory reserves and high levels indicating tissue hypercapnia may result in worse outcomes.
Methods: We conducted a retrospective review (2017-2023) of 343 patients undergoing pancreaticoduodenectomy for PDAC. Intraoperative ETCO2 data …
Evaluating The Impact Of Bard1 Isoform Targeting On Pdac Growth And Response To Olaparib, Lily Zekavat, Samuel Zion, Boxuan Wei, Avinoam Nevler, Aditi Jain
Evaluating The Impact Of Bard1 Isoform Targeting On Pdac Growth And Response To Olaparib, Lily Zekavat, Samuel Zion, Boxuan Wei, Avinoam Nevler, Aditi Jain
Alpha Omega Alpha Research Symposium Posters
Background
- BRCA-Associated Ring Domain 1 (BARD1), a heterodimeric binding partner of the tumor suppressor BRCA1, plays an essential role in homologous recombination-mediated DNA repair. Mutations in BARD1 increase cancer susceptibility and result in a molecular phenotype that predicts sensitivity to poly (ADP-ribose) polymerase inhibition (PARPi), including Olaparib.
- Several alternatively spliced isoforms of BARD1, including BARD1δ and BARD1φ, have also been implicated in tumor progression. These isoforms, characterized by deletion of exons 2-6 and 3-6, respectively, lack the RING domain required for BRCA1 interaction (Figure 1).
- Upregulation of BARD1 isoforms is associated with poor prognosis in several tumor types. However, the …