Digital Commons Network^™

Mutant Kras In Brain Endothelial Cells Promotes Vascular Inflammation And Impairs Vascular Integrity In Brain Arteriovenous Malformation, Jung-Eun Park, Bridger H Freeman, Hyejin Park, Sehee Kim, Adrian E Bafor, Ohnmar Myint, Song Gao, Zhen Xu, Jakob Körbelin, Jaroslaw Aronowski, Peng Roc Chen, Eunhee Kim, Eun S Park

Faculty, Staff and Student Publications

Somatic KRAS (KRASG12V) mutation in endothelial cells (EC) induces brain arteriovenous malformation (bAVM) that could lead to vascular instability and ultimately bleeding. However, the causes of bAVM instability remain unclear. Here we demonstrate that KRASG12V expressing cultured ECs (KRAS-G12V-EC) have increased expression of pro-inflammatory mediators and reduced expression of blood-brain-barrier (BBB) junction constituents. The conditioned medium from KRAS-G12V-EC can activate BV2-microglia (BV2-MG) and conditioned media from this primed BV2-MG can compromise the expression of EC-junction constituents when added to wild-type ECs. In an in vitro BBB model, KRAS-G12V-EC form a dysfunctional EC barrier that is further disrupted, leading to lower …

Transformative Technology And Shortening The Statute Of Limitations Applicable To Taxpayers, Jay A. Soled, Leslie Book

Faculty Publications

When it comes to submitting tax returns and paying taxes, most taxpayers understand the nature of their civic duties and do so dutifully, if not willingly. However, many taxpayers fail to grasp why the IRS has such an elongated time period—namely, three years— to audit their tax returns and propose an assessment. Indeed, when the IRS exercises its oversight authority, records may no longer be available, and memories may be dulled.

Since the original institution of the three-year tax assessment limitations period nearly a century ago, tremendous technological strides have been made. Indeed, over ninety percent of income tax returns …

Meta-Analytic And Economic Evaluation Of Fungicide Programs Applied For Managing Sclerotinia Stem Rot In Soybean Across The North Central United States, Hope Renfroe-Becton, Maria Oros, Adam M. Byrne, Martin I. Chilvers, Nathan Kleczewski, Horacio D. Lopez-Nicora, Brian D. Mueller, Daren S. Mueller, Damon L. Smith, Darcy E P Telenko, Richard Wade Webster

APC Fund Awardees

Farmers in the North Central United States are at risk of having soybean yield robbed due to infection by Sclerotinia sclerotiorum, the causal agent of Sclerotinia stem rot (SSR). While certain management strategies, such as wide row spacings, lower plant populations, and resistant varieties, can reduce SSR development, there is often a negative yield impact associated with these strategies. Conversely, chemical management strategies do not have an associated yield drag, and therefore, they have been the primary tool for suppressing SSR development. Independent chemical programs were evaluated across eight states from 2017 to 2024, resulting in 32 site-years (n = …

Visual Healing In Visual Communication Design: Exploring Calm Aesthetics For The Psychological Well-Being Of Urban Society, Siti Indah Lestari, Ivo Ramadhani

Bahasa dan Seni: Jurnal Bahasa, Sastra, Seni, dan Pengajarannya

This study investigates the concept of visual healing from a Visual Communication Design (VCD) perspective, focusing on its potential contribution to emotional comfort and psychological well-being among urban office workers. Contemporary workplace environments are increasingly characterized by prolonged screen exposure, dense visual information, and sustained cognitive demands, conditions that intensify visual fatigue and psychological strain. In this context, the study positions visual design not merely as an aesthetic practice, but as a psychologically responsive medium capable of shaping users' emotional experiences in everyday work settings. Employing a qualitative Research through Design (RtD) methodology, the study treats the design process as …

Emotional Intelligence And Problem-Solving Correlations And Impact On Employability: A Case Study From The Uae, Ganka Ivanova, Rakan Alhrhasheh

All Works

In this study, we aim to address questions about how UAE Leadership Development Plans and Employability connect with current students in UAE classrooms by evaluating the correlation between the employability of UAE university students and their emotional intelligence (EI) and problem-solving skills. Moreover, we cover what must be considered in the curricula of UAE Universities to prepare future leaders to lead the workforce. To that end, we employed an employability test developed by AQR International UK and collected data from 310 undergraduate students aged 17 to 55. Both EI and problem-solving skills were strongly positively correlated with employability (p < .001). Even though male participants scored higher than female participants for EI and problem-solving skills, analysis of variance revealed nonsignificant gender differences (p > .05 …

More Hours, More Work: Head Start Expansions Boost Maternal Employment, Chloe R. Gibbs, Esra Kose, Maria Rosales Rueda

Upjohn Institute Working Papers

Women’s employment remains highly sensitive to childcare constraints, making childcare availability a critical lever for supporting mothers’ labor force attachment. We study the effects of expanded full-day programming in Head Start, using the 2016 federal funding initiative that targeted grantees with low full-day enrollment. Linking administrative program data, geo-coded center locations, and household data on employment, we estimate a difference-in-differences design by comparing mothers of young children in treated and untreated areas. The policy increased full-day enrollment by 19 percent and raised single mothers’ employment (1.9%), hours (2.5%), and earnings (6.5%). Results show that extending program duration meaningfully improves maternal …

Green Synthesis Of Clitoria Ternatea L. Silver Nanoparticles Into Cotton Fabric For Antibacterial Activity, S. D. Hasarangi, J. A. L. P. Jayasinghe, S. M. J. C. Abhayasekara, M. S. D. Fernando, L. M. Hettihewa

Journal of Innovation in Science, Engineering and Technology

Clitoria ternatae L. is a medicinal plant rich in bioactive compounds and green synthesis of silver nanoparticles (AgNPs) using plant extracts offers a sustainable approach with reduced toxicity and minimum environmental impact. In this study, AgNPs were synthesized using aqueous extract of C. ternatae flowers and coated onto cotton fabric to evaluate its antibacterial activity. Dried flower powder (0.02 g) was extracted with distilled water and silver nanoparticles were synthesized using silver nitrate solution (3 mM) under at 50 °C. The nanoparticles were characterized using UV-Vis spectroscopy, Dynamic Light Scattering (DLS), Fourier Transform Infrared Spectroscopy (FTIR). Incorporation on cotton fabric …

Formulation And Development Of Herbal Sunscreen Gel From Leucas Zeylanica And Tagetes Erecta, P. K. Wanniarachchi, W. M. K. M. Ratnayake

Journal of Innovation in Science, Engineering and Technology

Leucas zeylanica (Family: Lamiaceae) and Tagetes erecta (Family: Asteraceae) are annual herbs traditionally used in home remedies and Ayurvedic medicine. Although both plants have been individually studied for their pharmacological properties, their synergistic effects and combined use in cosmetic formulations for sun protection have not been previously reported. This study aimed to evaluate the synergistic antioxidant and photoprotective activities of 95% ethanol extracts of the aerial parts of L. zeylanica, flower heads of T. erecta, and their combinations (1:1, 1:2, and 2:1). Antioxidant activity was assessed using the DPPH radical scavenging assay, with ascorbic acid as the positive …

Formulation And Development Of Skincare Cream Using Pleurotus Djamor, K. A. E. Madushanka, W. V. P. M. Weligalla, K. D. K. P. Kumari, W. M. K. M. Ratnayake

Journal of Innovation in Science, Engineering and Technology

Mushrooms have emerged as versatile and valuable resources in the cosmetic industry, offering a plethora of benefits that range from skincare to haircare formulations. As natural alternatives to synthetic ingredients, mushrooms not only cater to the growing consumer demand for sustainable and eco-friendly products but also offer unique properties such as antioxidant, anti-inflammatory and moisturizing effects. Hence, Pleurotus djamor, which is a grown mushroom in Sri Lanka was selected to prepare a new cream formulation for skincare. In the study, an aqueous extract of P. djamor (AEPD) was used and phytochemical screening was done to screen alkaloids, saponins, flavonoids, …

Identification Of Hnf1a Variants In A Mody-Suspected Sri Lankan Cohort Using Targeted Sanger Sequencing, V. R. Martin, V. Fonseka, A. N. Senanayake, S. M. Perera, N. Hemachandra, P. Weerasooriya, S. M. Samarasinghe, L. M. Hettihewa

Journal of Innovation in Science, Engineering and Technology

Among the many risk factors for Diabetes Mellitus (DM), genetic variations play an important role. Maturity Onset Diabetes of the Young (MODY) has emerged as a monogenic form of diabetes affecting young adults. MODY can be developed before the age of 25, emphasizing the urgent need for the identification of prognostic biomarkers for the early detection. MODY3 is a sub type that can be characterized by the impaired insulin secretion. HNF1A (HNF1 homeobox A) gene variants were reported to be associated with predisposing to MODY3 subtype. We conducted a pilot study to evaluate the genetic background of the suspected MODY3 …

Novel Technique For Enhancing The Therapeutic Efficacy Of Coenzyme Q10 In Transdermal Drug Delivery Systems For Skin Rejuvenation, L. M. Hettihewa, K. G. P. Wasana, Y. M. Imendra, G. P. C. Weerasooriya, W. M. K. M. Rathnayake

Journal of Innovation in Science, Engineering and Technology

Coenzyme Q10 (CoQ10) is a very imperative compound for electron transport chain in mitochondria and exerts its effects as cutaneous antioxidant. All human cells have CoQ10, and sometime deficiency had been identified due to genetic defects or with ageing. Supplements with COQ 10 are commonly used enteral and dermal application for the prevention and treatment of aging. Delivery of dermal CoQ10 is very limited due to its poor penetration and unstable compounds. systematic review was conducted by our research group through electronic databases using preclinical and randomized controlled trials to evaluate the efficacy and stability of improved delivery systems of …

Assessment Of Antioxidant Retention Of Boiled And Non-Boiled Aqueous Extracts Of Broccoli, Cabbage, Kohlrabi And Cauliflower In Sri Lanka, D. M. S. S. Dassanayake, B. C. K. Kumari, P. R. H. Perera, G. M. Yasasvi, L. M. Hettihewa, W. M. K. M. Ratnayake

Journal of Innovation in Science, Engineering and Technology

The comparison of antioxidant activities between non-boiled and boiled aqueous extracts of selected vegetables from the Brassica oleracea L. species is an interesting study topic, particularly in a context like Sri Lanka, where traditional and modern medicinal practices often emphasize the role of dietary plants in health. Hence, this was aimed to evaluate the antioxidant potential of boiled and non-boiled aqueous extracts (BAE and NBAE respectively) of selected vegetables belonging to the Brassica oleracea L species, which are commonly consumed as a raw vegetable in fresh salads as well as a cooked vegetable in curry or fried form i.e. Brassica …

Assessment Of In-Vitro Anti-Diabetic And Antioxidant Activities Of Selected Edible Mushrooms, Agaricus Bisporus (Button Mushroom), Pleurotus Cystidiosus (Abalone) And Pleurotus Ostreatus (American Oyster) In Sri Lanka, E. J. Siriwardene, G. S. D. Nawaruwan, A. H. M. A. N. Abesinghe, H. D. Dedigama, K. H. E. Fernando, K. D. K. P. Kumari, W. M. K. M. Ratnayake

Journal of Innovation in Science, Engineering and Technology

Mushrooms are a valuable source of proteins and vitamins as well as a food source with several pharmacological values. Hence, Higher mushroom consumption can lower the risk of certain diseases. However, a literature survey revealed that published scientific information on the therapeutic potential of some edible mushrooms is still being determined. Hence, this study evaluated and compared the antioxidant and α -amylase potential of some of the three commonly used mushroom varieties in Sri Lanka i.e. Agaricus bisporus (Button mushroom), Pleurotus cystidiosus (Abalone mushroom) and Pleurotus ostreatus (American oyster). The antioxidant activity of hot aqueous extracts of the above three …

Body Mass Index And Clinical Phenotypes Of Primary Dysmenorrhea In Female University Students: Evidence From Sri Lanka Using Walidd Scoring, H. K. A. N. Senanayake, K. L. A. S. I. Liyanarachchi, J. K. M. Jagoda, S. A. S. A. Maheepala, L. C. Mallawa, P. W. T. M. Dayarathne, Y. T. R. Somisena, L. M. Hettihewa

Journal of Innovation in Science, Engineering and Technology

This research investigates the relationship between body weight and the severity and characteristics of primary dysmenorrhea among female undergraduates in Sri Lanka, using the WaLIDD Score as an evaluative tool. The study aims to assess the practicality of the WaLIDD Score in native settings, examining its correlation with pain intensity, pain location, and common medication patterns, while addressing gaps in previous research conducted in Sri Lanka. A quantitative cross-sectional study was conducted among 389 female university students aged 19–27 years from both state and non-state universities in Sri Lanka, selected through stratified random sampling. Participants with chronic or menstrual diseases, …

Conceptual Analysis Of Ārthavavaha Srotas (Female Reproductive System): A Review Of The Theories And Literature, Pushpa Kulanatha, H. L. M. G. Sajeewani

Journal of Innovation in Science, Engineering and Technology

The reproductive health of females during their fertile years is foundational for individual well-being and societal prosperity. The purpose of this study was to bridge the analytical and epistemological gaps currently existing in the literature regarding Ārthavavaha Srotas (ĀvS), the Ayurvedic concept of the female reproductive system. A comprehensive literature review was conducted using forward and backward searches to analyse authentic Ayurvedic texts (Caraka and Sushruta Samhitas) alongside contemporary research articles published between 2014 and 2024. The analysis identified ten specific aspects of the ĀvS where prior interpretations were superficial or unclear. The results of this study epistemologically validate ancient …

The Prospector, Februrary 16, 2026, Utep Student Publications

The Prospector

No abstract provided.

Strspy2.0: Unlocking The Potential Of Long Reads For Forensic Dna Profiling, Courtney L Hall, Rupesh K Kesharwani, Katherine E Mcbroom Henson, Bupe Kapema, Nicole R Phillips, Fritz J Sedlazeck, Roxanne R Zascavage

Faculty, Staff and Students Publications

Forensic human identification relies on length-based differences in short tandem repeats (STRs) across autosomal and Y chromosomes, which require separate reactions and provide limited resolution. While next-generation sequencing offers greater discriminatory power, most platforms are expensive and restricted to traditional lab settings. Nanopore sequencing has the potential to change this with the real-time, portable MinION sequencer. However, forensic-specific tools that generate STR profiles compatible with established length-based databases are lacking. To address this, we developed STRspy2.0, which simultaneously profiles autosomal and Y-STRs using nanopore reads. STRspy2.0 produced accurate profiles for 54 multiplexed control libraries and 41 mock casework samples (blood, …

Modeling Spasticity: A Systematic Review, Gaby Gonzalez Chan, Jonathan Marsden, Alexander Besinis, Pablo Borja, Hilary Gunn

School of Health Professions

Spasticity, a type of hypertonia characterized by a velocity-dependent increase in muscle tone, is associated with damage to the brain and/or spinal cord in different neurological conditions. However, secondary non-neurological factors, such as soft tissue changes, can complicate the assessment and differentiation of the underlying causes. Accurate assessment is crucial for effective treatment planning, with clinicians relying on passive movement to grade the ‘feel’ of the spastic limb. This review aims to identify and evaluate the feasibility of spasticity models or simulations for clinical teaching. Models based on human spastic limbs were examined, with no restrictions on specific conditions or …

Author Correction: Intracranial Directed Connectivity Links Subregions Of The Prefrontal Cortex To Major Depression, John Myers, Jiayang Xiao, Raissa K Mathura, Ben Shofty, Victoria Gates, Joshua Adkinson, Anusha B Allawala, Adrish Anand, Ron Gadot, Ricardo Najera, Hernan G Rey, Sanjay J Mathew, Kelly Bijanki, Garrett Banks, Andrew Watrous, Eleonora Bartoli, Sarah R Heilbronner, Nicole Provenza, Wayne K Goodman, Nader Pouratian, Benjamin Y Hayden, Sameer A Sheth

Faculty, Staff and Students Publications

No abstract provided.

Myelodysplastic Syndrome Secondary To Chimeric Antigen Receptor T-Cell (Car-T) Therapy For The Treatment Of Relapsed/Refractory Multiple Myeloma, Waqqas Tai, Daniel Kim, Joe Dib, Jessica Thomas, Swathi Gopishetty, Precious Idogun, Afoma Anyadibe, Anuoluwa Ayetoran, Syed Zaidi, Savitha Balaraman, Ishmael Jaiyesimi

Student Publications

We present the case of a 65-year-old man with relapsed/refractory multiple myeloma (RRMM) who developed therapy-related myelodysplastic syndrome (MDS) following chimeric antigen receptor T-cell (CAR-T) therapy with idecabtagene vicleucel (ide-cel). The patient, initially diagnosed in 2019, underwent multiple lines of therapy, including high-dose melphalan with autologous stem cell transplantation, before receiving ide-cel for progressive disease. Despite initial remission, a day 100 bone marrow biopsy revealed MDS with a 7q deletion, a cytogenetic abnormality not present on prior marrow evaluations. While CAR-T therapy has revolutionized RRMM treatment, long-term complications such as therapy-related hematologic malignancy remain under-recognized.

The temporal relationship between CAR-T …

Chimes: February 16, 2026, Calvin University

Chimes

Faculty Senate approves a reduction in graduation credit-hour requirement by Maya Oeverman

Fluoridation documentary examines how we talk about politics by Alec DeYoung

Track and field gains momentum as indoor championships are underway by Zach Kern & Hendrick Beelen

Lent: Going back to basics by Ella Vanden Berg

What it means to be American by Maya Oeverman

How A Holistic Approach To People Of Reproductive Age Can Support Access To Preconception Care For People Living With Health Conditions: Findings From A Realist Evaluation, Heather Hopper, Kerryn Husk, Kate Maslin, Jill Shawe

School of Nursing and Midwifery

This realist evaluation explored how access to preconception care works for people with pre-existing health conditions, for whom, and in what contexts. Thirty one participants (women of reproductive age, partners, and healthcare professionals) were interviewed using qualitative realist methods. Iterative analysis refined 35 initial programme theories into 13 middle range theories. The theory reported here identifies healthcare professionals’ knowledge of sexual and reproductive health, understanding of pregnancy planning, and enquiry regarding pregnancy intention as key mechanisms. In the context of diagnosis or review, these resources support holistic and individualized preconception care, enabling improved preconception health and reduced adverse maternal and …

Molecular Detection Of Genes Encoded For Biofilm Formation In Bacteria Isolated From The Oral Cavity Of Patients, Tebarek Al-Taei, Ali A. Al-Hisnawi

Karbala International Journal of Modern Science

Background: A biofilm is a collection of the microbial cells attached to the surface that are encased in a matrix of extracellular polymers. Biofilm formation creates a physical and chemical barrier that prevents antibiotics from reaching bacterial cells, resulting in treatment failure and reinfection. The present study aimed to investigate the biofilm formation in bacteria isolated from the oral cavity of patients.

Methods: In this study, 150 bacterial isolates were obtained from tooth and gum surface swabs of male and female patients of different ages who visited specialized centers and dental clinics in Babylon City after they were clinically diagnosed …

Assessment Perception: Delivery Matters, Nicole Marie Arcuri Sanders, Chelsey Simmons

Journal of Counselor Preparation and Supervision

Perception shapes how individuals experience the world and guides their actions toward personal goals. In counseling, clients’ accurate understanding of assessment results is essential for informed decision-making and effective treatment engagement. Mental health clinicians have an ethical responsibility to communicate findings in ways that safeguard client welfare and empower both clients and stakeholders to collaborate in care. This conceptual manuscript introduces the BRIEF (Brief, Relevant, Interpretive, Empathetic, and Factual) Feedback Integration Framework, a structured model for delivering assessment feedback ethically and accessibly. Integrating cognitive, developmental, and cultural considerations. BRIEF provides counselors, supervisors, and educators with a practical strategy for improving …

Addressing Saintly Corrections: An Integrative, Developmental Approach To Counselor Bias Management, Travis Walker, Jennifer M. Cook

Journal of Counselor Preparation and Supervision

No person is without biases, even the most culturally adept among us. Managing biases is critical to counselors’ continued journey of understanding clients contextually and holistically. In this article, we describe two novel bias management concepts: A specific type of bias called saintly corrections and the more clinically fruitful approach of realistic corrections. We define and illustrate saintly and realistic corrections, outline a multifold approach (i.e., cognitive complexity, cultural identity development, and the multicultural orientation model) for remediating saintly corrections, and offer recommendations counselor educators can use during planned and contextual learning opportunities, including an example of a contextual …

Teaching Multicultural Counseling: A Phenomenological Exploration Of Counselor Educators’ Voices, Cameka Hazel, Paul Leheste, Raymond Blanchard

Journal of Counselor Preparation and Supervision

This study explored the perceptions of counselor educators who taught the graduate level multicultural counseling course. Six participants shared experiences, leading to four themes: personal and professional rewards, who is fit to teach? dealing with resistance and difficult conversations and limited time and class size. Implications for counselor education are discussed.

Competencies And Preparation For Addressing Poverty In Counselor Education: A Q Methodological Study, Seneka Rachel Gainer

Journal of Counselor Preparation and Supervision

This study explored the competencies needed to prepare counselors to address the systemic and relational impacts of poverty within counselor education. Using Q methodology, expert participants identified critical knowledge, skills, and awareness factors required for effective practice. Two distinct factors emerged: (1) the centrality of relational competencies such as empathy, cultural humility, and trust-building, and (2) the necessity for curriculum-wide integration of poverty-specific training and systemic advocacy. Findings highlight the need for counselor education programs to embed poverty-related competencies across curricula, foster interdisciplinary collaboration, and develop experiential and advocacy-based training models. Implications for counselor education, accreditation standards, and professional development …

Counselors’ Experiences Of The Alliance In Videoconference Supervision: The Role Of Nonverbals, John E. Trenery, Azra Karajic Siwiec, Randall L. Astramovich

Journal of Counselor Preparation and Supervision

The role of nonverbal immediacy and intimacy in shaping the supervisory alliance during videoconference-based clinical supervision is understudied. Using a generic qualitative research design, data were collected from 15 practicing counselors through semi-structured interviews. Thematic analysis identified six primary themes, highlighting both the perceived barriers and the essential role of nonverbal cues, as well as the need for amplified behaviors in video-based interactions. The findings point to significant gaps in telesupervision training and introduce a novel framework to strengthen telepresence in videoconference supervision. This study offers actionable insight for educational institutions and governing bodies, emphasizing the importance of targeted curricula …

Dismantling Racism In The Classroom: Recommendations For White Male Counselor Educators, Jason L. Vannest, Rebecca J. Vannest, Lorise D. Grey

Journal of Counselor Preparation and Supervision

In response to the historical tradition of Eurocentrism and Whiteness in counseling programs in the United States, the American Counseling Association (ACA) and the Association for Counselor Education and Supervision (ACES) have challenged their members to confront implicit bias, become allies with Black Indigenous People of Color (BIPOC), and commit to challenging racism and implicit bias. Despite these robust calls to disrupt racism and implicit bias, counselor educators - specifically White male counselor educators (WMCEs) - may wonder how to effectively take action due to their own racial identity. Several factors may contribute to WMCEs' reticence to deconstruct racism and …

The Feminist Impostor Phenomenon Approach (Fipa): A Feminist Approach To Addressing Impostor Phenomenon In Novice Counselors, Isabel Springer, Kelly Emelianchik-Key

Journal of Counselor Preparation and Supervision

Impostor Phenomenon (IP) is known to affect new professionals in health professions, yet there is little to no academic literature available on how it affects early career counselors and how it can be addressed. Novice counselors (NC) frequently experience extreme anxiety and feelings of fraudulence around their professional performance. Feminist mentorship and interventions can help alleviate IP and foster self-efficacy and confidence in new counseling professionals. The Feminist Impostor Phenomenon Approach (FIPA) consists of a three-hour workshop educating participants through a feminist lens about IP and relevant coping strategies, and subsequent weekly consciousness-raising groups where coping strategies are reinforced, and …