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Bronchiectasis In Children, Murat Kuru, Tamer Altınok

Journal of Pediatric Infectious Diseases

Bronchiectasis, although less common in children than in adults, is an important long-standing respiratory disease marked by permanent enlargement of the bronchi and impaired airway function. The main symptom is a chronic wet cough. This condition presents a considerable health challenge in children, especially in developing countries where access to healthcare may be limited. Although cystic fibrosis (CF)-related bronchiectasis is relatively common, non-CF bronchiectasis, often triggered by post-infectious causes, predominates in pediatric populations. The diagnosis of bronchiectasis is confirmed by demonstrating a bronchoarterial ratio > 0.8 on high-resolution computed tomography. Medical treatment includes mucolytic agents, bronchodilators and antibiotics. Surgical resection of …

Heart Rate Variability In Children With Moderate And Severe Traumatic Brain Injury: A Prospective Observational Study, Sophie Martin, Geneviève Du Pont-Thibodeau, Andrew Je Seely, Guillaume Emeriaud, Christophe L. Herry, Morgan Recher, Jacques Lacroix, Laurence Ducharme-Crevier

Journal of Pediatric Intensive Care

Objective: To assess feasibility of continuous monitoring of heart rate variability (HRV) in children with traumatic brain injury (TBI) hospitalized in a Pediatric Intensive Care Unit (PICU) and collect preliminary data on the association between HRV, neurological outcome and complications. Method: Prospective observational cohort study in a tertiary academic PICU. Children are admitted to the PICU 24 h after moderate or severe TBI were included. Children suspected of brain death at PICU entry or with a pacemaker were excluded. Children underwent continuous monitoring of electrocardiographic (ECG) waveforms over 7 days post TBI. HRV analysis was performed retrospectively, using a standardized, …

Unplanned Extubations In Pediatric Critical Care: A Case-Control Study, Krista Wollny, Cameron B. Williams, Raghad Al-Abdwani, Carol Cartelle, Jason Macartney, Helena Frndova, Norbert Chin, Christopher Parshuram

Journal of Pediatric Intensive Care

Objectives: To quantify associations between the risk of unplanned extubation and patient-, environment-, and care-related factors in pediatric critical care; and to compare outcomes between children who did and did not experience an unplanned extubation. Methods: Retrospective case-control analysis including patients <18 years who experienced an unplanned extubation during ICU admission (2004-2014). Cases were matched by age, duration of mechanical ventilation, and date to control-patients (4:1) who were intubated but did not experience an unplanned extubation. Conditional logistic regression was used to evaluate associations between unplanned extubations and the abstracted characteristics. Results: We identified 1601 eligible controls matched to 458 case-patients. When adjusted for confounders, eight variables were associated with unplanned extubation: three patient-related factors (previous ICU admission, previous intubation, and the volume of secretions); one environment-related factor (patient room set-up); and four care-related factors (intubation route, and the use of sedation, muscle relaxation and restraints). Patients who had an unplanned extubation had longer length of stay, but lower rate of mortality. Conclusions: This is the largest case-control study identifying variables associated with unplanned extubation in pediatric critical care. Several are potentially modifiable and may provide opportunities to improve quality of care in controlled ICU environments.

Utility Of Pediatric Early Warning Sign Score In Predicting Outcome Of Picu Admissions At A Suburban Tertiary Care Hospital, Deepika Aggarwal, Shahzad Alam, Rufaida Mazahir, Rupa Rajbhandari Singh, Baljeet Maini

Journal of Pediatric Intensive Care

Background: Assessment of the severity of illness is very important in ICU care for quality assessment, assessing prognosis, and proper counselling. The goal of the study was to see how well the Pediatric Early Warning Score (PEWS) predicted the outcome of PICU patients. Methods: This prospective cross-sectional study included children under 18 years of age. PEWS was calculated at presentation. The outcomes analysed were mortality (primary outcome), need for mechanical ventilation, inotropic support, and length of stay (LOS). A median score was calculated and compared across the outcome groups. The performance of the PEWS was assessed for calibration and discrimination, …

Dexmedetomidine Opioid Sparing Effect In Mechanically Ventilated Children (Dose): Trial Of Fentanyl Vs. Fentanyl + Dexmedetomidine For Maintenance Of Sedation, Mara L. Becker, Gwenyth Fischer, Chi D. Hornik, Omar Alibrahim, Kelechi Iheagwara, Kamal Abulebda, Andora L. Bass, Katherine Irby, Anjali Subbaswamy, Elizabeth E. Zivick, Jill Sweney, Anne G. Stormorken, Erin E. Barker, Shruthi Mahadaveiah, Riad Lutfi, Michael C. Mccrory, John M. Costello, Kate G. Ackerman, Jennifer C. Munoz-Pareja, Bryan J. Feger, J. Michael Dean, Daniel F. Hanley, Rachel G. Greenberg, Radhika Avadhani, Richard E. Thompson, Daniel K. Benjamin, Christoph P. Hornik, Kanecia O. Zimmerman

Journal of Pediatric Intensive Care

Objectives: To observe the mean daily dose of fentanyl required for adequate sedation in critically ill, mechanically ventilated children randomized to receive dexmedetomidine or placebo. Methods: We conducted Dexmedetomidine Opioid Sparing Effect in Mechanically Ventilated Children (DOSE), a multicenter, double-blind, randomized, placebo-controlled, dose-escalating trial. We enrolled children aged 35 weeks post-menstrual to 17 years (inclusive) admitted across 13 pediatric multidisciplinary and cardiac intensive care units. Adequate sedation was based on a State Behavioral Score and Richmond Agitation-Sedation Scale of -1 or lower. Only the first two dexmedetomidine dosing cohorts opened for enrollment, due to early trial closure during the coronavirus …

Variability In Clinician Awareness Of Intravenous Fluid Administration In Critical Illness: A Prospective Cohort Study, Stephen M. Gorga, Alexander L. Sliwicki, Julie Sturza, Erin F. Carlton, Ryan P. Barbaro, Rajit K. Basu

Journal of Pediatric Intensive Care

Objective: Intravenous (IV) fluids are commonly administered to critically ill children, but clinicians lack effective guidance for the correct dose and duration of therapy resulting in variation of prescribing habits which harm children. It is unknown if clinicians recognize the amount of IV fluid that patients receive. We aimed to determine clinician accuracy in the identification of the volume of IV fluids patients will receive over the next 24 hours. Methods: Prospective cohort study enrolled all patients admitted to the PICU from May-August 2021 at the University of Michigan’s C.S. Mott Children’s Hospital Pediatric Intensive Care Unit (PICU). For each …

Emergent Bedside Re-Sternotomy: An Innovative Simulation Model For Training Pediatric Cardiac Intensive Care Teams, Toluwani Akinpelu, Nikhil R. Shah, Mohammed Alhendy, Malarvizhi Thangavelu, Karen Weaver, Nicole Muller, James Mcelroy, Utpal S. Bhalala

Journal of Pediatric Intensive Care

Introduction: Cardiac tamponade after cardiac surgery is a life-threatening event that requires simultaneous resuscitation and emergent re-sternotomy by the intensive care team. A simulated scenario using an innovative mannequin with sternotomy wound has the capability of reproducing cardiac arrest associated with postoperative tamponade. We evaluated the validity of this mannequin to investigate the confidence level and crisis resource management skills of the team during bedside re-sternotomy to manage postoperative cardiac tamponade. Methods: The simulation scenario was developed using the sternotomy mannequin for a pediatric cardiac intensive care unit (CICU) team. The case involved a 3-year-old male, intubated, mechanically ventilated after …

Issue 480 February 19-March 5, 2026, The Local Voice

The Local Voice

Featured Articles: "Mississippi Arts Commission Funds Writer Studio at Greenfield Farm."; "Beth Ann Fennelly’s The Irish Goodbye and the Art of Truth-Telling."; "The View Beyond The Balcony: Ice Storm Fern in Your Own Words."

Outbound Investment Restrictions And International Law’S Challenge, Harlan Grant Cohen

Seattle University Law Review

The Outbound Investment Rule, restricting U.S. investment in certain Chinese advanced technology sectors, has largely been portrayed as an incremental measure, a modest extension to fill loopholes in the existing investment screening regime. But while perhaps the logical next step in the securitization of the economy, the Outbound Investment Rule actually reflects a momentous shift in the relationship between governments and business, one playing out in the United States and around the world and worth attention. Unlike traditional investment screening, the Outbound Investment Rule operates like a sanctions regime, designed not to protect the U.S. economy, but to hamper the …

Orthognathic Surgery: Why Is It Done?, Mia Gou

Mentorship Program 2025-2026

No abstract provided.

“Lifesaver” Training: Promoting Safety And Emergency Preparedness In A Higher Education Workplace, Allison R. Jones, Nanci A. Claus, Stephanie Hammond, Karen L. Heaton, Summer Langston Powers, Penni I. Watts

Creating Healthy Work Environments (CHWE)

Workplace violence and unintentional injury in settings of higher education have increased in frequency in recent years. The National Institute for Occupational Safety and Health developed a set of practices, programs, and policies collectively known as Total Worker Health®, that includes emphasis on promoting workplace safety and injury prevention. Nurses in academic roles present a unique population in that they have foundational healthcare education but may limited in or far removed from prior emergency response training. Further, little research exists on implementation and outcomes of workplace safety programs in settings of higher education. We developed and implemented an internal, voluntary …

An All-Inclusive Toolkit For Managing Workplace Violence In Healthcare, Brittney L. Williamson, Melissa Rouse

Creating Healthy Work Environments (CHWE)

Violence against nurses is a nationwide problem that has set the stage for unhealthy work environments and has driven nurses away from patient care. So, what can be done to retain our nurses and provide safer work environments? By creating an all-inclusive toolkit for managing violent and aggressive patients, this healthcare organization has made great strides to better protect their nurses.

Impact: To address this problem head on, evidence-based practices were used to develop an all-inclusive toolkit to implement a multifaceted approach to assessment, de-escalation, and allocation of resources. This approach took the guesswork out of what steps to take …

Using Simulation To Mitigate Workplace Violence, Lynda Sanchez, Monique D. Wilson, Derek Sanchez

Creating Healthy Work Environments (CHWE)

Workplace violence is not new to healthcare whether it is interprofessional, nurse to nurse, doctor to nurse, patient/patient family to healthcare worker. (Kumari et al., 2022) There is a need to provide the healthcare worker with tools and training on ways to mitigate workplace violence (WPV). Simulation is an effective evidence-based teaching and evaluation method often used in healthcare. (Brown et al., 2018; Gutiérrez-Puertas et al., 2020) In an attempt to mitigate WPV this organization began a mandated training using didactic classes from an external training program. This program involved required computer-based pre-work and attendance at a three-hour class which …

Resilient Dispute Resolution Systems For International Energy Conflicts, Guillermo J. Garcia Sanchez

Seattle University Law Review

Energy-related conflicts are on the rise, spanning diverse issues such as the impacts of rare mineral mining on local communities, the impacts of sanctions on energy investments due to the Russia-Ukraine war, and the impacts of expanded subsidies on the electric vehicle and solar panel industries. Increasingly, companies, communities, and governments are clashing over the challenges of pursuing disparate and sometimes competing energy policies. This Article argues that dispute resolution mechanisms in the energy investment sector must be fundamentally rethought. Traditional semi-adjudicatory models, which focus on winners and losers, fail to accommodate the complex and multifaceted nature of contemporary energy …

Restricting Data Flows Is A Sign Of Weakness, Nikolas Guggenberger

Seattle University Law Review

There has been a seismic shift in American attitudes toward the free flow of data across borders.  In less than a decade, the United States has transitioned from condemning barriers to digital trade to constructing a digital fortress of its own. It passed legislation requiring TikTok’s parent company to divest its U.S. operations or face a nationwide ban affecting 170 million U.S. users, citing national security concerns about its ties to China and the potential for data surveillance and content manipulation. Upon legal challenge by TikTok on First Amendment grounds, the Supreme Court affirmed the ban’s constitutionality. Recent federal legislation …

Product Nationality And Corporate Identity, Trang (Mae) Nguyen

Seattle University Law Review

Global supply chains have long depended on a deceptively technical device: the attribution of a “nationality” to goods. A trade law principle, rules of origin assign products an “economic passport” that governs how they are treated at the border, including what markets they may enter and which tariff rates apply. In recent years, however, product nationality has taken on a new and far more ambitious role. As U.S. trade policy increasingly intersects with national security and human rights policy, policymakers rely on nationality-based measures to police supply chain linkages, curb geopolitical issues, and discipline firms for their links to forced …

Global Supply Chain Resilience In Emerging Technologies: A Case Study Of Bitcoin Mining, Kishanthi Parella, Carla L. Reyes

Seattle University Law Review

The United States has put into motion bold plans in critical and emerging technologies to bolster its national and economic security.  For example, the federal government created a national bitcoin strategic reserve and a stockpile of other cryptocurrency; while several states have committed to or are considering similar goals.  However, the security of these reserves is dependent on two types of supply chains within the Bitcoin mining industry: analogue supply chains, relating to the physical components needed for Bitcoin mining, and data supply chains, relating to the complex and layered logistical network of actors that create input into the software …

Disruption Of Proteoglycan 4 (Prg4)-Cd44 Signaling Modulates Chronic Synovitis In Conditionally Inactivated Mice, Khaled A. Elsaid, Ling Zhang, Thomas Zhao, Ava Marks, Derek Jenkins, Gregory D. Jay

Pharmacy Faculty Articles and Research

Background

Proteoglycan-4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblasts and superficial zone chondrocytes. PRG4 inhibits synovial macrophage (SM) activation via xanthine oxidase (XO) and hypoxia inducible factor alpha (HIF-1α) suppression. We aimed to evaluate the contribution of PRG4-CD44 interaction to synovial homeostasis and investigate PRG4’s signaling dysfunction in synovial tissues from patients with osteoarthritis (OA). We hypothesized that CD44 mediates synovitis due to PRG4 loss and that PRG4 signaling dysfunction is associated with high-grade synovitis in OA.

Methods

Prg4^{FrtloxP/FrtloxP} are transgenic mice wherein tamoxifen (TAM) inactivates the Frt allele and creates a knockout state (Prg4^{FrtKO/FrtKO …}

Conditioned Feed Aversion As A Means Of Conditioning Livestock To Avoid Consuming Toxic Plants Growing In South Africa : An Overview, Leendert D. Snyman, Frederick D. Provenza

Poisonous Plant Research (PPR)

Significant economic losses to the livestock industry are caused by the ingestion of toxic plants in South Africa, among which the most dangerous ones are Moraea pallida (geeltulp), Urginea/Drimea sanguinea (rooislangkop), Senecio latifolius (Staggers Ragwort), and Geigeria ornativa (vermeerbos). Conditioned feed aversion is a potential means to address this issue. Treating animals with an aversive substance along with an extract of the sensory characteristics of a specific plant conditions animals to avoid the plant. Geigeria ornativa, unlike the other three plants, is non-aversive. Following treatment for aversion, the induced aversion fades with time and eventually breaks down. Continuous exposure …

The Indiana Statesman, February 19, 2026, Indiana State University

Student Newspaper

Alex Kor speaks to Honors College; A Tad of Grad: An exhibition of color and wonder

February 19, 2026, Caa

Minutes

No abstract provided.

Volume 49 Masthead

Seattle University Law Review

Volume 49 Masthead

A Comparative Study Of Chinese And American Approaches To Shaping International Outer Space Law And Norms, Ariel G. Silverman

Seattle University Law Review

This article explores convergences and divergencies in the United States and PRC’s responses to the stalemate in the United Nations over the future of outer space resource governance. I do so by systematically analyzing these leading space-faring nations’ policy-positions and tactics deployed to shape norms around three substantive areas of outer space resource governance: rights of ownership and scope of utilization of space resources, mechanization of the “benefits sharing” principle, and the rights and responsibilities of the private sector. I theorize that these leading space-faring nations have adopted divergent approaches due to their differing historical relationships with international law and …

A Phenomenological Approach To Spastic Movement Disorders: An International Expert Panel Consensus, Bo Biering-Sørensen, Jörg Wissel, Raymond Rosales, Rajiv Reebye, Jorge Jacinto, Gerard E Francisco, Peter Sanderson, Per Ertzgaard

Faculty, Staff and Student Publications

Background and objectives: Hyperkinetic movement disorders, characterized by complex and overlapping motor patterns, present significant challenges in classification and treatment. The inconsistency in definitions and descriptors complicates both research and clinical communication. This study aims to provide an overview of current terminology and definitions related to spasticity and other hyperkinetic movement disorders associated with central nervous system lesions. We propose a unified terminology and classification system for spastic movement disorders (SMD).

Methods: In this scoping review, definitions of spasticity, dystonia, tremor, chorea, hemiballismus, athetosis, myoclonus, and dyssynergia were reviewed, with emphasis on overlaps and diagnostic challenges among these disorders. The …

Management Of Alcohol Withdrawal Syndrome In The Emergency Department, Janet Fuller

Walden Dissertations and Doctoral Studies

This Doctor of Nursing Practice project involved development and approval of a clinical practice guideline (CPG) for management of alcohol withdrawal syndrome (AWS) in the emergency department (ED) of a large community trauma center in the southeastern United States. AWS is a common, potentially life-threatening condition requiring timely assessment and intervention to prevent. Variability in ED screening and treatment contributes to delayed intervention, increased rapid response activations, and intensive care transfers. The project purpose was to develop and obtain expert approval of an evidence-based CPG using the Clinical Institute Withdrawal Assessment for Alcohol–Revised (CIWA-Ar) tool to support standardized screening, symptom-triggered …

Cv: Jennifer Tello Buntin (Sociology), Jennifer Tello Buntin

Sociology Department Faculty Curricula Vitae

No abstract provided.

Finance Committee Meeting - Open Session Book 02/19/2026, Uc Law Sf

2026 Board of Directors Agenda and Materials

No abstract provided.

Educational Policy Committee Meeting – Open Session Book 02/19/2026, Uc Law Sf

2026 Board of Directors Agenda and Materials

No abstract provided.

Detecting And Managing Youth At Risk For Suicide: Using Research To Inform Practice, Lisa M. Horowitz

Grand Rounds

No abstract provided.

Table Of Contents

Seattle University Law Review

Table of Contents