Digital Commons Network^™

Peri-Operative Warfarin Protocol To Decrease Length Of Stay After Left Ventricular Assist Device Implantation, Laura Hencken, Gillian Grafton, Long To, Hassan Nemeh, Jennifer A. Cowger

Pharmacy Meeting Abstracts

Purpose: A limitation to left ventricular assist device (LVAD) implantation is cost with fixed reimbursement rates for the LVAD implantation hospitalization regardless of hospital length of stay and costs. Patients must have a therapeutic INR on warfarin prior to discharge which can take days and delay discharge. The purpose of this study is to evaluate the impact of a peri-operative warfarin protocol on decreasing length of stay during index LVAD implantation.

Methods: This is a retrospective single center study of adult patients undergoing LVAD implantation between January 1, 2019 and December 31, 2020. Patients who died during the admission were …

Improving Cancer Survivor Quality Of Life Through Exercise Rehabilitation, Vincent Falzone

Research Papers

No abstract provided.

Physical Activity/Sport Performance And The Benefits Of Virtual Reality- A Systematic Review, Madeline Rushing

Research Papers

No abstract provided.

High School Students’ Math And Science Motivation Profiles: Stability And Relationship With Their Stem Career Aspirations, Jiali Zheng

Theses and Dissertations

Motivation to study mathematics and science is an important influencing factor of career aspirations in STEM fields which predicts STEM major choice in college and STEM careers after graduation. Using restricted data from a nationally representative sample HSLS:09, the current study identified U.S. high school students’ motivation profiles in mathematics and science courses in 9^th and 11^th grade, examined the stability of these profiles across the two time points, and studied the association between 11^th grade motivation profiles and STEM career aspirations. Differences between male and female students in motivation profiles, profile stability and career aspirations were …

Mediator Kinase Inhibitors For Breast Cancer Therapy, Xiaokai Ding

Theses and Dissertations

Breast cancers (BrCa) that overexpress oncogenic tyrosine kinase receptor HER2 are treated with HER2-targeting antibodies (such as trastuzumab) or small-molecule kinase inhibitors (such as lapatinib). However, most patients with metastatic HER2+ BrCa have intrinsic resistance and nearly all eventually become resistant to HER2-targeting therapy. Resistance to HER2-targeting drugs frequently involves transcriptional reprogramming associated with constitutive activation of different signaling pathways. We have investigated the role of CDK8/19 Mediator kinase, a regulator of transcriptional reprogramming, in the response of HER2+ BrCa to HER2-targeting drugs. Selective CDK8/19 inhibitors (senexin B and SNX631) showed synergistic interactions with lapatinib and trastuzumab in a panel …

Comparative Assessment Of The Fate And Toxicity Of Chemically And Biologically Synthesized Silver Nanoparticles Toward Juvenile Clams, Mercenaria Mercenaria, Amar Yasser Al-Rshim

Theses and Dissertations

Engineered nanomaterials (ENMs) with unique nanoscale properties, including novel optical behavior and superparamagnetic, are continually being developed for biomedical and industrial applications. In specific biomedical applications, ENMs are surface-functionalized using polymers, proteins, and other stabilizing agents to facilitate their resistance to salt-induced aggregation. Since their colloidal stability in high ionic-strength matrices, functionalized ENMs are anticipated to be persistent aquatic contaminants. Despite their potential environmental significance, the persistence of surface-functionalized ENMs as individually stabilized nanoparticles in marine environments is largely unknown. Further, few studies have investigated the fundamental factors that influence ENMs uptake and fate/transport processes in ecologically susceptible aquatic biota, …

Comfort Food For The Ears: Exploring Nostalgic Trends In Popular Music Of The Twenty-First Century, April K. Balay

Theses and Dissertations

This thesis will examine trends in twenty-first-century American popular music characterized by a sonority sometimes labeled “retro” or “vintage,” the production of which, I contend, often corresponds to periods of cultural upheaval, and social, political, and economic change. Engaging specifically with music produced during the COVID-19 pandemic of 2020, the economic recession of 2008, and the terrorist attacks of September 11, 2001, my work will strive to update the dialogue between music in this century with the styles of the past that it recalls. By examining music beginning in the year 2001 and analyzing airplay charts and recording techniques, I …

Evaluation Of The Perceived Benefit Of A Psychiatric Resource For Parents Of Children With 22q11.2 Deletion Syndrome, Kayla Blankenship

Theses and Dissertations

The objective of this study was to assess the perceived utility of an educational resource booklet addressing the psychiatric manifestations and mental health considerations within 22q11.2 deletion syndrome (22q11.2DS).

Seventy-three parents of children with 22q11.2DS completed online surveys before and after reading the booklet. The surveys assessed personality factors and feelings of empowerment, worry, self-stigma, and ability to tolerate uncertainty.

Participants reported that the booklet was easy to understand, provided better understanding of 22q11.2DS and mental illness, answered questions about mental illness associated with the condition, improved knowledge of strategies for protecting the mental health of children with the condition, …

Homestead Vegetable And Poultry Production And Related Practices: An Assessment In Nepal, Shiva Bhandari

Theses and Dissertations

Consumption of nutrients-rich foods like diverse vegetables, eggs, and meat throughout a year remains a challenge in low- and middle-income countries due to poor availability, accessibility, and affordability. One important way to overcome the challenge is to promote households’ own production of these foods and encourage individuals to consume. Improving household production of the foods necessitates understanding whether active participation and performance of frontline workers in the communities and performing improved production-related practices can translate into improved production of nutrients-rich foods. This study had two specific aims. The first aim was to examine demographic, socio-economic, and programmatic determinants of active …

The Effects Of The Online Remediation Of Phonological Processing Deficits On Functional Reading Abilities In Students With Dyslexia, Fletcher Bowden

Theses and Dissertations

Dyslexia affects between 5% and 18% of Americans and is caused by difficulty with phonological processing. This study investigates the impact of an online intervention designed to remediate phonological processing deficits on reading accuracy, fluency, and comprehension. It also investigates changes to student self-concept and parent perceptions of their children’s reading attitudes and abilities as a result of the online intervention.

Ten students participated in the intervention; assessments were administered at the beginning and at the midpoint of the treatment. Scores in Phonological Processing and Alternate Phonological Processing, as measured by the CTOPP-2, demonstrated large to very large effect sizes, …

The Relation Between Adhd Symptoms And Alcohol And Marijuana Use Outcomes Among College Students: The Mediating Role Of Experiential Avoidance, William Joshua Bradley

Theses and Dissertations

Individuals with attention-deficit/hyperactivity disorder (ADHD) are at significantly greater risk for alcohol and marijuana misuse and abuse compared to their peers. College students with ADHD may be particularly vulnerable to problematic alcohol and marijuana use, given the widespread use and abuse of these substances by college students generally and liability associated with ADHD specifically. Experiential avoidance, or avoidance of unwanted thoughts, feelings, and other internal experiences, is positively associated with ADHD symptoms and substance use problems. However, it is unclear what role experiential avoidance plays in the relation between ADHD and alcohol and marijuana use. This study examined whether experiential …

“Why Do I Have To Learn This Anyway?”: A Qualitative Investigative Action Research Study Into The Tension Between The Rural, Working-Class Masculine Student And The Formal Educative Structure, Joshua Matthew Bowers

Theses and Dissertations

The specific problem of practice on which this study was focused is the tension experienced between the rural (National Center for Education Statistics, 2016), workingclass (Draut, 2018) masculine (Connell, 1995) student and the formal educative structure. The purpose of this investigative action research study was to identify and clarify in my context the unique tension experienced between the rural, working-class masculine student and the formal educative structure. This tension I refer to as tention, as tention is a variant of tension (Oxford English Dictionary, 1994, p. 789), and the rural, workingclass masculine student is, at his unique nexus of intersectionality, …

Assessing Parental Satisfaction Of Current Fragile X Syndrome Resources Provided At Diagnosis, Megan Michalski

Theses and Dissertations

Diagnosis of a child with fragile X syndrome (FXS) is associated with parental anxiety. Existing literature recommends FXS resources, but there has not been a formal assessment of when parents learn about these resources, or their satisfaction with them. Studies have demonstrated negative feelings surrounding the diagnostic experience of FXS. This exploratory analysis assessed the gap in knowledge on parental satisfaction of the recommended resources from healthcare providers during the time of diagnosis. We predicted parents would not be satisfied with the way resources were presented to them. We discussed parental satisfaction or dissatisfaction, utility of the recommended resources, and …

Life In The Time Of Covid-19: The Everyday Impacts Of The Pandemic In Amman, Jordan, Patrick Mckenzie

Theses and Dissertations

The COVID-19 pandemic and the responses taken to combat it caused enormous changes to the everyday lives of people around the world. Jordan, in its early success against the virus and with its large refugee population, represents a unique country in which to study these everyday impacts. From May to August of 2021, I conducted ethnographic fieldwork in the Jordanian capital city of Amman while working with the refugee nongovernmental organization the Collateral Repair Project. In this thesis, I explore the COVID-19 Spectacle, examining the ways in which policies and discourses at the national and international scales bled into the …

Suas And Deep Learning For High-Resolution Monitoring Of Tidal Marshes In Coastal South Carolina, Grayson R. Morgan

Theses and Dissertations

Tidal marshes are dynamic environments, now more than ever threatened by both natural and anthropogenic forces. Best practices for monitoring tidal marshes, as well as the environmental factors that affect them, have been studied for more than 40 years. With recent technological advances in remote sensing, new capabilities for monitoring tidal marshes have emerged. One of these new opportunities and challenges is hyper-spatial resolution imagery (<10 >cm) that can be captured by small unmanned aerial systems (sUAS). Aside from enhanced visualization, structure-from-motion (SfM) technology can derive dense point clouds from overlapped sUAS images for high resolution digital elevation models (DEMs). …

Examining Parental Disclosure To Unaffected Siblings Of Children Diagnosed With Rett Syndrome, Rachel Nicely

Theses and Dissertations

Rett syndrome is a neurodevelopmental disorder that is inherited in an X-linked dominant manner due to pathogenic variants in the MECP2 gene that are almost always de novo. It is one of the most common causes of developmental delay and intellectual disability in females and occurs in about 1 in 10,000 females. While there is valuable literature surrounding the impact of a neurodevelopmental diagnosis on unaffected siblings, there are no articles about the impact of a disclosure of Rett syndrome to unaffected siblings and the needs of parents during this disclosure. This study aimed to examine the disclosure process …

Moderating Effects Of Parental Feeding Practices And Emotional Eating On Dietary Intake Among Overweight African American Adolescents, Mary Quattlebaum

Theses and Dissertations

This study examined the effects of parental feeding practices and adolescent emotional eating (EE) on dietary outcomes among overweight African American adolescents. Based on Family Systems Theory, it was hypothesized that parental feeding practices, such as parental monitoring and responsibility, would buffer the effects of EE on poor dietary quality, whereas practices such as concern about a child’s weight, restriction, and pressure-to-eat would exacerbate this relationship. Adolescents (N = 127; Mage = 12.83 ۫.74; MBMI % = 96.61 ± 4.14) provided baseline data from the Families Improving Together (FIT) for a Weight Loss trial and an ancillary study. Dietary outcomes …

Graph Neural Network And Phylogenetic Tree Construction, Gaofeng Pan

Theses and Dissertations

Deep Learning had been widely used in computational biology research in past few years. A great amount of deep learning methods were proposed to solve bioinformatics problems, such as gene function prediction, protein interaction classification, drug effects analysis, and so on; most of these methods yield better solutions than traditional computing methods. However, few methods were proposed to solve problems encountered in evolutionary biology research. In this dissertation, two neural network learning methods are proposed to solve the problems of genome location prediction and median genome generation encountered in phylogenetic tree construction; the ability of neural network learning models on …

Investigating The Role Of Stressful Life Events And Emotion Regulation As Potential Antecedents Of Gratitude In Early Adolescents, Olivia Schmitke

Theses and Dissertations

ABSTRACTThe construct of gratitude has gained interest over the last decade along with the rise of positive psychology. Gratitude’s significant relations with psychological and psychosocial factors have been shown in prior research, although support for such relations in children and adolescents exists, to date the literature is more robust around adults. Additionally, presumed antecedents of individual differences in gratitude have been acknowledged. The present study included a sample of 1872 middle school students and aimed to build on previous work to explore the influence of emotion regulation (i.e., cognitive reappraisal and expressive suppression) in the development of gratitude among youth …

Sexual Health Education For Children With Neurodevelopmental Disorders: Genetic Counselor And Pediatrician Perspectives, Mary Catherine Smith

Theses and Dissertations

Many barriers prevent individuals with disabilities from receiving appropriate sexual health education (SHE), including deficits in socialcommunication skills and lack of resources and trained educators. There are few guidelines specifically addressing how to accommodate for providing SHE to individuals with disabilities. Healthcare professionals who are trained in working with adolescents with disabilities, such as pediatric genetic counselors, developmental-behavioral pediatricians (DBP), and neurodevelopmental disabilities (NDD) subspecialty pediatricians, could fill this gap. The purpose of the current study was to assess what informational items pediatric genetic counselors, DBP, and NDD subspecialty pediatricians felt were most essential to include in SHE for children …

The Impact Of Framing On Natural Gas Pipeline Siting In Virginia, Ritvik Shukla

Theses and Dissertations

Natural gas has become a major share of energy consumption in the U.S. over the past two decades. This rise has resulted in considerable investment in the natural gas pipeline network so that the supply can be maximized. However, pipeline infrastructures, much like other fossil fuel energy infrastructures and activities, have an uneven distribution of benefits and costs across different regions. In regions where natural gas activities and infrastructure are being developed, local communities can become increasingly dependent on natural gas systems for stable revenue and employment. Such communities risk becoming “locked in” to carbon energy at a time when …

The Effects Of Ionizing Radiation On Domestic Dogs: Ancestry And Genetic Structure Of Free-Roaming Dog Populations In Chernobyl, Ukraine, Gabriella Jean Spatola

Theses and Dissertations

This thesis is concerned with the effects of ionizing radiation on domestic dogs (Canis lupus familiaris) which were commonly used as laboratory subjects during the era of atomic bomb testing (1950s - 1980s). Early laboratory studies on radiation effects in dogs provided important foundations of knowledge for research that has more recently shifted to natural populations exposed to ionizing radiation from nuclear accidents. A unique group of free-roaming dogs reside in an environment polluted by radioactive contamination deposited during the Chernobyl nuclear disaster of 1986, providing one such opportunity to study the effects of ionizing radiation on dogs …

Infertility Education For Men With Cystic Fibrosis And Its Effects: Outlooks On Fertility And Birth Control, Allison Elizabeth Perez Szczepanski

Theses and Dissertations

Many men with Cystic Fibrosis (CF) are infertile; however, few studies have evaluated fertility outlook of men with CF since the advent of modulator therapy. As predicted survival and quality of life improve, family planning is an area of increased interest for the CF community. The current study surveyed men with CF to explore their outlook on fertility, family planning, and birth control use with the option to receive a home fertility test and follow-up interview with study staff.

Seventy-five men with CF completed the survey and 53 (71%) believed they were likely infertile. Most recalled learning about infertility between …

Gatekeeping Blackness: Roles, Relationships, And Pressures Of Black Television Journalists At A Time Of Racial Reckoning, Denetra Walker

Theses and Dissertations

Building on Du Bois’ (1903) concept of double-consciousness, Critical Race Theory, and communications theories including Gatekeeping, this dissertation aims to provide understanding of the experiences of Black broadcast journalists at a racially contentious time in American history. In 2020-2021, following the deaths of Black Americans at the hands of police and subsequent Black Lives Matter protests, and during a global pandemic, a “racial reckoning” ensued throughout the nation. The reckoning, which continued through the writing of this dissertation, was a salient issue for news media. Through my positionality as a Black female forever journalist, I interviewed 29 Black journalists who …

Resurrecting A Nation Through Silk And Diplomacy: American Material Culture And Foreign Relations During The Reconstruction Era, Paige Weaver

Theses and Dissertations

The Reconstruction Era, a time of immense change in American culture and society, is often conceptualized as a wholly domestic affair; however, a closer analysis of the work of American diplomats scattered throughout the world reveals the impact of foreign policies and relationships on the development of the nation state, as well as cultural values. With this broadened perspective, Reconstruction becomes a more complicated period of entangled international concerns and influences in a globally connected world.

This thesis argues that intricate international relations and complex foreign policies helped shape American identity and values at home. Diplomats abroad in countries such …

Adsorption Of Microcystins To Sediment Affects Their Bioavailability And Remediation, Ashley Womer

Theses and Dissertations

The freshwater harmful algae Microcystis spp produces a family of toxins called microcystins1. These species of algae are known to release microcystins from their cells directly into the surrounding water2. This creates an array of human health risks depending on the fate and transport of the toxins in the water column3,4. Risk modelling and previous literature has shown that sediment is a sink for free microcystin, microcystin can be stably adsorbed to sediment for hundreds of years, and its adsorption to sediment is determined by the sediment adsorption partitioning coefficient (Kd)5,6,7. In this work it is hypothesized that the sediment …

Associations Between Child Characteristics And Maternal Mental Health In Families Of Children With Autism, Fragile X Syndrome, And Autism Associated With Fragile X Syndrome, Tiffany Nicole Worley

Theses and Dissertations

The present study examined the association between various child characteristics and maternal mental health concerns in three high-risk groups of mothers ± those of children with non-syndromic autism spectrum disorder (NSASD), mothers of children with fragile X syndrome (FXS), and mothers of children with fragile X syndrome and autism (FXS+ASD). Research has shown that mothers of children with NSASD and FXS are thought to share a degree of genetic vulnerability to mental health concerns it is key to examine the various other factors that may contribute to difficulties within the family system and maternal stress, depression, and anxiety.

Participants for …

“Zoom Degrees”: A Reflection On Education And Experience During The Covid-19 Pandemic Of The 2020s, Campbell Childers

Theses and Dissertations

This thesis is a self-reflection on time in the three-year Master of Fine Arts in Theater program at the University of South Carolina, during the 2020 rise of the Covid-19 Pandemic and the years after. It is a chronologically structured examination of two years of academic experiences, both prior to and during the pandemic, and one year of professionally application experience post-pandemic. The academics cover course experiences to production assignments and design opportunities, going into detail on the student’s process and thoughts at the time. The reflections on professional experience discuss the student’s future goals and how they have evolved …

Race, Racial Matching, And Cultural Understanding As Predictors Of Treatment Engagement In Youth Mental Health Services, Wendy Chu

Theses and Dissertations

Racially marginalized youth experience barriers that impact their ability to maximally benefit from mental health services; thus, efforts to identify strategies that support youth treatment engagement may address mental health and treatment disparities. This study examined the role of youth race, youth-therapist racial matching, and youthreported therapist cultural understanding on youth’s early treatment engagement in mental health services. The youth sample (n = 1159; M_age = 13.8 years, SD = 2.9; 52.1% female) comprised of 778 (67.1%) Latinx, 221 (19.1%) African American, 139 (12.0%) White, and 21 (1.8%) Asian American clients. The therapist sample (n = 126; Mage …

Supervisory Allyship For University Custodial Staff, Daniel Colascione

Theses and Dissertations

This study will examine the lived experiences of campus custodians in search of creating an anti-racist workplace. Custodians will have the opportunity to share about their experiences involving racism and will be asked to explain their expectations of leadership in creating an anti-racist workplace. This study seeks to understand the expectations Black staff members have of their departmental and university level leadership to identify ways to narrow the gap between their expectations and the support they receive from those in positions capable of doing so.