Digital Commons Network^™

Jnk And Nf-Κb Cell Signaling Pathways In Cardiovascular Disease Present Potential Targets For Curcumin Therapy, Mary Richfield

Senior Honors Theses

Curcumin (diferuloylmethane) is a compound derived from the rhizomes of Curcumin longa that has been long used for medicinal purposes. Curcumin alleviates the pathology of cardiovascular diseases, including atherosclerosis, aneurysm, and cardiomyopathy. The mechanism of curcumin therapy is under active research. The NF-κB and JNK pathways are two that curcumin interacts with to block inflammatory processes, apoptosis, and fibrotic tissue remodeling to prevent the pathologies of cardiovascular disease. While curcumin has demonstrated powerful mediation of cardiovascular disease, its bioavailability in body tissues is limited due to the instability and hydrophobicity of its structure. Further work is underway to stabilize …

The Cutaneous Microbiome Of The Eastern Red-Spotted Newt (Notophthalmus Viridescens) And Its Role As Defense Against Fungal Pathogens, Joseph Bierbaum

Senior Honors Theses

Chytridiomycosis is a life-threatening disease which infects amphibian species worldwide. Chytrid fungi Batrachochytrium dendrobatidis (Bd) and Batrachochytrium salamandrivorans have been found to be the primary causes of chytridiomycosis. In past research, it has been found that the skin microbiome of certain amphibian species could have fungal inhibition properties, reducing the effects of the chytrid fungi. In this study, 15 eastern red-spotted newts (Notophthalmus viridescens) were collected, to determine if cutaneous bacteria of the newts secrete antifungal compounds. Pure cultures of each bacterium morphotype were produced from mass culture plates, with 188 morphotypes being isolated. The antifungal properties …

The Role Of Mtorc1 In Autophagy As It Relates To Cancer, Olivia Robinson

Senior Honors Theses

The mammalian target of rapamycin complex 1, mTORC1, is composed of several subunit proteins with many cellular responsibilities including participation in a complex cell signaling cascade leading to autophagy, which is the regulated degradation of cell components. mTORC1 is frequently mutated or dysregulated within human cancer. Normally, mTORC1 functions to provide efficient regulation of autophagy according to intracellular levels of growth factors, amino acids, nutrients, oxygen levels, and more that can either inhibit mTORC1 and upregulate autophagy or activate mTORC1 and downregulate autophagy. A better understanding of mTORC1 is imperative to preparing cancer therapy treatments. Various cancerous tissue types require …

Communicating Comfort In Crisis: A Literature Review On Overcoming The Emergency Room Environment To Foster The Nurse-Patient Relationship, Faith G. Davenport

Senior Honors Theses

The average emergency room patient is not receiving the compassionate nurse-patient communication that patients experience on other hospital floors. Fewer positive nurse-patient interactions prompt patients to state that they feel uncomforted and dissatisfied on hospital exit surveys, inciting hospital management to investigate how to reverse this trend to retain their federal funding. Emergency room nurses cite multiple barriers inherent in their work environment that prevent them from building rapport with their patients, including a layout not conducive to private conversations, strict time constraints, and a fluctuating workload. Working for a prolonged period under these conditions is driving many nurses to …

Hamstring And Quadriceps Strength Ratio In Collegiate Wrestlers, Jesse Redding

Senior Honors Theses

ACL injuries are a significant risk for athletes across sports. One of the sports that reports the highest rate of ACL injury is wrestling. The mechanism of injury among wrestlers appears to be unique and has limited data compared to other sports. Several nonmodifiable risk factors have been studied for ACL injury, as well as several modifiable risk factors that include BMI, muscular composition, and high-risk movements. The hamstring to quadriceps strength ratio (H:Q) is one aspect of muscular composition that has received little attention in collegiate wrestlers. The purpose of this study was to analyze the H:Q strength ratio …

The Yeast Glucose Sensing Receptor Is Stabilized By Interaction With Casein Kinases, Emma E. Mohler

Senior Honors Theses

Many metabolic diseases are rooted in the inability to process glucose or regulate its uptake. These processes can be explored using yeast as a model. Rgt2 is a glucose sensing receptor in yeast, and it detects glucose concentration outside the cell. This receptor is present on the plasma membrane in high glucose conditions but absent in low glucose. Western blot and a yeast two-hybrid assay were used to investigate the relationship between Rgt2 and the plasma membrane-tethered yeast casein kinases, Yck1 and Yck2. This research demonstrated that in high glucose, Rgt2 is stabilized on the plasma membrane by interaction with …

Situational Crisis Communication Theory And The British Royal Family, Addison Shaw

Senior Honors Theses

This thesis will analyze the public relations of the British Royal Family as seen through the lens of Timothy Coombs’ Situational Crisis Communication Theory (SCCT). Coombs’ (2007) theory provides a theoretical framework and guidelines for crisis response strategies when organizations experience a crisis. This thesis will particularly evaluate the public relations of the British Royal Family during the aftermath of Princess Diana’s death by examining primary artifacts such as newspaper articles and public statements made by the organization and the public. Furthermore, this thesis fills in the research gap regarding the evolution of the public’s perception of an organization with …

Evaluating Validity And Deviant Personality: What The Myers Briggs Type Indicator Overlooks, Mikayla Burton

Senior Honors Theses

Perhaps the most widely recognized personality assessment in the world, the MBTI has been implemented as a valuable predictive and diagnostic tool by innumerable businesses, coaches, psychologists, and interested individuals. However, recent research has shown that the MBTI is host to a variety of significant validity issues, and the test altogether fails to address any aspects of deviant personality. A review will draw attention to the consequential validity issues of the MBTI, its overlooking of deviant personality characteristics, and the repercussions of using such an unsound and exclusive personality test. The suitability of HEXACO as a viable alternative for the …

Impact Of Risk Perception And Risk Tolerance On Investment Portfolio Decisions, Claire Covey

Senior Honors Theses

Average individual investor returns drastically underperform standard investment benchmarks, with common attributing factors including relying on instincts and overconfidence in trading ability. Neural processing, financial risk, risk perception, and risk tolerance literature show how instinctual reactions form and how those reactions affect risk decision-making under the Prospect theory. Examining the effect of neural processing and risk framing on subjective risk perception allows a measurement of the indirect impact on risk tolerance. The stable factors of risk tolerance directly impact investment risk decisions. There are implications of accurately assessing risk tolerance in a client/advisor relationship. Advisor application of a proper risk …

The Theme Park Throwdown: The Successes And Failures Of Ip-Related Attractions And Expansions In Disney Theme Parks And Strategies For The Future, Aubree Zern

Senior Honors Theses

The Disney brand invokes strong feelings of loyalty from supporters and dissatisfaction from its opponents, and it many facets play an important part in society (Havard et al., 2021). It is certainly true that “the Magical World of Disney remains unsurpassed in terms of brand name recognition, planning complexity, and detailed execution. It is the paradigmatic ideal of how architecture can establish a universe around its landscape” (Dalov, 2019, p.10). For nearly 70 years, the Imagineers cultivated an idea from the mind of one man into a global phenomenon of twelve theme parks and counting (Tang & Iwerks, 2019). The …

Sleep Disruptions Within The Hospital, Faith Walls

Senior Honors Theses

The circadian rhythm is a complex and interwoven system within each human being that creates an internal clock each day. However, patients in all hospital settings continue to have their sleep disrupted by many factors. Seep being disrupted in the hospital patients can develop serious complications. To this day, the issues causing have not been adequately assessed and therapeutically intervened with consistency within nursing practice. Using the Whittemore and Knalf Framework, this integrative review will examine the literature on aspects of inpatient care that contribute to circadian disruptions within hospitals. By doing so, the research can be built upon with …

An Overview Of The Forensic Analysis And Use Of Non-Human Dna, Kaelyn Long

Senior Honors Theses

DNA is present in every living organism on Earth. DNA is also present in a few non-living biological agents such as DNA-containing viruses, and is additionally unique to particular groups of organisms and often even to individuals. This characteristic allows DNA to be quite useful in forensic investigations. This study takes an in-depth look at the forensic use of non-human DNA. DNA analysis is a key component of many forensic investigations, but the majority of these analyses are focused on human DNA. This review examines the ways in which non-human DNA can be useful to forensic investigations. The various unique …

Exploring Water Filtration Methods For Implementation In Rural Mozambique, Cole Glasson

Senior Honors Theses

Of Mozambicans living in rural areas, nearly two-thirds are without access to clean drinking water sources, leading to waterborne diseases and diarrhea. Thus, a great need exists for an effective and sustainable water treatment solution for rural Mozambicans. Boiling, solar disinfection, and membrane-based processes are analyzed with respect to their effectiveness and economic sustainability in an attempt to propose a solution to those living in rural Mozambique. The most sustainable option is membrane-based processes, with two particular systems showing the most promise: Skyhydrant™ and LifeStraw®. These two ultrafiltration system are extremely effective at retaining almost all forms of bacterial and …

Sars-Cov-2 Reveals That Chimeric Agents Are The Bioweapons Of The Future, Rachel Craig

Senior Honors Theses

Bioweapons programs have existed since their development during the Cold War. These biowarfare programs initially utilized naturally occurring pathogens capable of infecting crops, livestock populations, and human populations. Anthrax is a widely exploited bioagent responsible for attacks ranging from the Germans’ deployment in World War I to the mailing of anthrax through the postal service in attempts on U.S. senators’ lives. With the development of genetic manipulations, the Soviet Union began modifying anthrax to resist detection and treatment. With the continued advancement of science and technology, a new bioagent has entered the scene – the man-made chimeric virus. Chimeric viruses …

The Pathology And Treatment Of Osteoporosis, Shea Munnikhuysen

Senior Honors Theses

Osteoporosis is a disease that causes bone fragility and decreased bone mass. Osteocytes and signaling molecules regulate the function of osteoclasts and osteoblasts. The RANK pathway is a key regulator in osteoclastogenesis. When the osteoclastic function is greater than osteoblastic function, bone integrity decreases. Causes of osteoporosis include hormones, medications, and diet. Treatments for osteoporosis are hormonal, medicinal, and lifestyle changes. More research needs to be done to find more effective medications with fewer negative side effects to improve the overall quality of life for patients. Currently, lab trials are being done on potential new medications to treat osteoporosis.

Determining The Genomic Localization And Binding Partners Of Zinc Finger Protein 410, Mariko Locke

Senior Honors Theses

The results of a folate deficiency study affecting cognition in mice suggested the altered genes may be controlled by a transcription factor known as Zinc Finger Protein 410 (Zfp410). Due to a lack of literature on Zfp410’s interacting proteins and DNA-binding location, our study aims to further elucidate the role Zfp410 plays in affecting cognition. A custom antibody was used to determine the Zfp410 isoforms present in mouse and rat brains. Moreover, the antibody was used to determine the binding partners of Zfp410 in the brain and locate specific genomic regions/sequences with which it associates in vivo. These results may …

The Effect Of Creative Art Therapy On Trauma Victims Suffering From Post-Traumatic Stress Disorder, Sophia Swiatek

Senior Honors Theses

When confronted with a traumatic situation, individuals’ brains often face difficulty in storing and/or processing such experiences. Unfortunately, this presents challenges for accessing those memories later in life, especially if the individuals are solely using speech-based techniques to do so. This fact has spurred research on whether various other therapeutic techniques, such as Creative Art Therapy (CAT), can produce better results in improving the mental health of a trauma victim suffering from Post-Traumatic Stress Disorder (PTSD). This study attempts to uncover whether age, gender, and/or type of therapy play a significant role in the improvement of CAT clients’ mental health …

Non-State Actors "Under Color Of Law": Closing A Gap In Protection Under The Convention Against Torture, Anna R. Welch, Sangyeob Kim

Faculty Publications

The world is experiencing a global restructuring that poses a serious threat to international efforts to prevent and protect against torture. The rise of powerful transnational non-state actors such as gangs, drug cartels, militias, and terrorist organizations is challenging states’ authority to control and govern torture committed within their territory.

In the United States, those seeking protection against deportation under the Convention Against Torture (“CAT”) must establish a likelihood of torture at the instigation of or by consent or acquiescence of a public official acting in an official capacity or other person acting in an official capacity. However, what is …

Lived Experiences Of Adults Formally Raised By Grandparents On Their Connection To The School Community While In High School, Karen M. Maguire

All Theses And Dissertations

This qualitative interpretative phenomenological analysis sought to understand the lived experiences of connectedness to the secondary school community of children raised by grandparents, told from the reflective viewpoint of the grandchildren now as adults. Although the relationship between grandparents and the grandchildren they raise has been studied, how those grandchildren connect to the school community has yet to be explored and was the focus of this study. Research on grandchildren raised by grandparents and student connection to the school community provided valuable insight, highlighting the need for additional exploration in this area. Education researchers have studied student engagement quite thoroughly, …

Did The Clean Air Act Improve Environmental Justice Disparities?, Jared Jageler

Economics Honors Projects

This paper analyzes the differential impacts of the 1990 Clean Air Act Amendments (CAAA) on the racial pollution exposure gap, also known as the Environmental Justice (EJ) gap. Using recently developed, Census tract-level satellite data of PM2.5 pollution, I test whether CAAA non-attainment status and resulting State Implementation Plans decreased pollution in high-percentage Black and Hispanic areas more than in non-high percentage Black and Hispanic tracts. My results confirm that the CAAA reduced overall pollution concentrations in the U.S. and decreased the absolute level of the Environmental Justice gap. A heterogeneity analysis provides evidence that the results are primarily driven …

Accreditation Woes: Thinking Outside The Box For Program And Course Assessment Design – Competency And Outcome Rubrics In Canvas, Nicole Espinoza

UNLV Best Teaching Practices Expo

Using competency-based rubrics and proper assessment design in course, program, and/or university levels allows for an instructor and administration to see the level of knowledge attainment for student, course, or full program. This poster will showcase how a degree program approached assessments with a new lens - using Canvas rubrics and outcomes. It will showcase the piloted program data for the MHA program. Even though this data is specific to a graduate degree program, this assessment design can be used by all individuals, courses, and programs!

In Situ Recording Of Mars Soundscape, S. Maurice, B. Chide, N. Murdoch, R. D. Lorenz, D. Mimoun, R. C. Wiens, Arya Udry, The Supercam Team

Geoscience Faculty Research

Before the Perseverance rover landing, the acoustic environment of Mars was unknown. Models predicted that: (1) atmospheric turbulence changes at centimetre scales or smaller at the point where molecular viscosity converts kinetic energy into heat1, (2) the speed of sound varies at the surface with frequency2,3 and (3) high-frequency waves are strongly attenuated with distance in CO2 (refs. 2,3,4). However, theoretical models were uncertain because of a lack of experimental data at low pressure and the difficulty to characterize turbulence or attenuation in a closed environment. Here, using Perseverance microphone recordings, we present the first characterization of the acoustic environment …

Microbial Contamination On Ambulance Surfaces: A Systematic Literature Review, Adam Obenza, Patricia Cruz, Mark Buttner, D. Woodard

Environmental & Global Health Faculty Research

Healthcare-associated infections (HAIs) are infections that patients acquire while receiving medical treatment in a healthcare facility. During ambulatory transport, the patient may be exposed to pathogens transmitted from emergency medical service (EMS) personnel or EMS surfaces. The aim of this study was to determine whether organisms commonly associated with HAIs have been detected on surfaces in the patient-care compartment of ambulances. Five electronic databases – PubMed, Scopus, Web of Science, Embase and Google Scholar were used to search for articles using inclusion and exclusion criteria following the PRISMA checklist. Inclusion criteria consisted of articles published in English, between 2009 and …

Insar As A Tool For Monitoring Hydropower Projects: A Review, J. Aswathi, R. B. Binoj Kumar, Thomas Oommen, E. H. Bouali, K. S. Sajinkumar

Michigan Tech Publications, Part 1

This paper provides a review of using Interferometric Synthetic Aperture Radar (InSAR), a microwave remote sensing technique, for deformation monitoring of hydroelectric power projects, a critical infrastructure that requires consistent and reliable monitoring. Almost all major dams around the world were built for the generation of hydropower. InSAR can enhance dam safety by providing timely settlement measurements at high spatial-resolution. This paper provides a holistic view of different InSAR deformation monitoring techniques such as Differential Synthetic Aperture Radar Interferometry (DInSAR), Ground-Based Synthetic Aperture Radar (GBInSAR), Persistent Scatterer Interferometric Synthetic Aperture Radar (PSInSAR), Multi-Temporal Interferometric Synthetic Aperture Radar (MTInSAR), Quasi-Persistent Scatterer …

Effectivenessofnursingguidelinesonnursesperformanceregardinghighalertmedications, Sara Sayed Abdalla

Nursing

No abstract provided.

Program: The Sound Of Music, University Of Dayton, Teejai Dorsey

Dance and Theater Programs

Music by RICHARD RODGERS

Lyrics by OSCAR HAMMERSTEIN II

Book by HOWARD LINDSAY and RUSSEL CROUSE

Suggested by "The Trapp Family Singers" by Maria Augusta Trapp

Music and Lyrics for "I Have Confidence" and "Something Good" by Richard Rodgers

April 8-9, 2022

Boll Theatre in Kennedy Union

Co-produced by the Theatre, Dance, and Performance Technology program and the Department of Music

Set in 1938 amidst the rise of nationalism, The Sound of Music is a story of being true to one’s authentic self in the face of social and religious division. Maria is a novitiate who struggles with the constriction …

Teacher-Student Relationships Influencing Classroom Management Of Challenging Behaviors: A Case Study, Kristen Slifko

Doctoral Dissertations and Projects

The purpose of this case study was to understand how teacher-student relationships influence classroom management of students with challenging behaviors for teachers of ninth- grade Multi-tiered System of Supports (MTSS) students at Blue High School. The theory guiding this study was Glasser’s choice theory. All human behavior is driven by the desire to satisfy the five basic needs: survival, freedom, fun, power, and love. Behaviors happen because of personal choices made in an attempt to fulfill those needs. This idea served as a framework for all research and data collection. The method used for this case study was qualitative with …

Pastoral Care And The Alleviation Of Compassion Fatigue In Staff At St. Mary's Hospice, Ellen Chloe Gardner-Cook

Doctoral Dissertations and Projects

This action research project studied compassion fatigue in hospice staff and the ways that Christian prayer practices can mitigate compassion fatigue symptoms and contribute to resiliency. The sample population included forty employees and the sample size was N=6. The participants answered four anonymous, self-report assessments to measure six areas, compassion satisfaction, self-compassion, secondary traumatic stress, burnout, perceived stress, and spirituality at the first of eight weekly sessions. These assessments included the Professional Quality of Life Scale (ProQOL), the Perceived Stress Scale, the Spiritual Intelligence Self-Report Inventory, and the Self-Compassion Scale. Six weeks of prayer interventions followed the initial assessments then …

Best Buddies Club: A Phenomenological Study Of The Non-Disabled Peer Perspective On Socially Interacting With Students With Disabilities, Joanna Marie Cavender

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to describe the shared experience of non-disabled peers serving as a “best buddy” to high school students with a disability in the southeastern United States. The theory guiding this study was Vygotsky’s Social Constructivism Theory, where learning between two diverse learners occurs through social interaction with one another, specifically a high school student with a disability and a non-disabled peer buddy. Participants in this study (N=14) were selected from three different high schools throughout one school district, each with active extracurricular Best Buddies Clubs in place. Data were collected through 1:1 interviews, …

Compassion Fatigue And Burnout: When Caring Becomes Too Much, Ruth Elisabeth Cole

Doctoral Dissertations and Projects

The purpose of this DMIN thesis is to provide resources and education for clinical staff to recognize and reduce compassion fatigue and burnout. Compassion fatigue and burnout in hospice clinical staff is a sizeable issue. Clinical staff was defined as doctors, nurses, social workers, chaplains, and aides due to their direct and constant contact with dying patients. By providing resources and education on what compassion fatigue and burnout look like and the primary causes, the study aimed to help clinical staff in the hospice care setting to reduce the damage caused by compassion fatigue and burnout. Resources including counseling sessions, …