Digital Commons Network^™

Fruits Of Nandina Domestica Are (Sometimes) Cyanogenic And (Sometimes) Hazardous To Birds, Scott Zona

Poisonous Plant Research (PPR)

A 12-month survey of cyanogenesis in the fruits and leaves of Nandina domestica (Berberidaceae) revealed that the leaves are strongly cyanogenic throughout the year, as measured by the Feigl-Anger test. Fruits vary in their cyanogenic potential depending on the degree of ripeness and clone. Green fruits are strongly and rapidly cyanogenic, but most ripe fruits are weakly and slowly cyanogenic. Some fruits tested negative for cyanide. Fruits tend to become less cyanogenic the longer they remain on the plant, so birds feeding on older fruits are at a lower risk of poisoning. More than other frugivores, cedar waxwings (Bombycilla …

Promoting Community Accessibility Through Advocacy And Networking With The Ability App, Chloe C. Moore

OTD Capstone Projects

Promoting Community Accessibility Through Advocacy and
Networking with The Ability App Networking with The Ability App

Ransomware Incident Preparations With Ethical Considerations And Command System Framework Proposal, Stanley Mierzwa, James Drylie, Dennis Bogdan

Center for Cybersecurity

Concerns with cyber-attacks in the form of ransomware are on the mind of many executives and leadership staff in all industries. Inaction is not an option, and approaching the topic with real, honest, and hard discussions will be valuable ahead of such a possible devastating experience. This research note aims to bring thoughtfulness to the topics of ethics in the role of cybersecurity when dealing with ransomware events. Additionally, a proposed set of non-technical recovery preparation tasks are outlined to help organizations bring about cohesiveness and planning for dealing with the real potential of a ransomware event. Constraints from many …

A Mixed Method Study Of Teachers’ Appraisals Of Student Wellness Services And Supports During Covid-19, Tasha M. Childs, Elizabeth Levine Brown, Naomi Brown, Aidyn Iachini Ph.D., Kate Phillippo, Linda Galib, Audra Parker, Ken Fujimoto

Faculty and Staff Publications

BACKGROUND: Understanding teachers' appraisals of student wellness services and supports during COVID-19 is essential to strengthening services and improving student health outcomes. This mixed-method study aimed to examine US PK-12 teachers' appraisals of student wellness services and supports during COVID-19.

METHODS: This study focuses on qualitative data from 291 teachers' open-ended responses to the question: “What do you wish your school leaders knew about this (wellness support) aspect of your work?” and whose responses described wellness services and supports. A qualitative content analysis was conducted by an interdisciplinary research team using open- and axial coding.

RESULTS: Three …

Antibody Dependent Enhancement Of Infectious Bronchitis Virus In Poultry, Zachary Hamilton, Barry Simpson, Donald L. Reynolds

UCARE: Research Products

Avian infectious bronchitis (IB) is a coronavirus infection of chickens that causes respiratory disease and reproductive problems in chickens. Currently, there are vaccines that are effective against IB. However, new variants and strains of avian infectious bronchitis virus (IBV) routinely emerge. A vaccine that is not the same strain as the virus is not completely effective in protecting against other variants because the vaccine will not allow the host antibodies to completely neutralize the strain. This is a problem because it makes IB difficult to control and diagnose.

Antibody-dependent enhancement (ADE) is a phenomenon whereby non-neutralizing antibodies, or low levels …

Decompression And Interlaminar Stabilization For Lumbar Spinal Stenosis: A Cohort Study And Two-Dimensional Operative Video, Olivia E. Gilbert, Sarah E. Lawhon, Twila L. Gaston, Jared M. Robichaux, Gabriel Claudiu Tender

School of Medicine Faculty Publications

Background and Objectives: Lumbar spinal stenosis is one of the most common causes of disability in the elderly and often necessitates surgical intervention in patients over the age of 65. Our study aimed to evaluate the clinical efficacy of interlaminar stabilization following decompressive laminectomy in patients with lumbar stenosis without instability. Materials and Methods: Twenty patients with lumbar stenosis underwent decompressive laminectomy and interlaminar stabilization at our academic institution. Clinical outcomes were measured using the visual analog scale (VAS) and Oswestry disability index (ODI) at the 2-month, 6-month, and 1-year postoperative visits, and these outcomes were compared to the preoperative …

Embedding Interdisciplinary Learning Into The First-Year Undergraduate Curriculum: Drivers And Barriers In A Cross-Institutional Enhancement Project, Rebecca Turner, Debby Cotton, David Morrison, Pauline Kneale

Professional Services

Engaging with interdisciplinary learning during higher education (HE) study can provide students with skills and modes of thinking informed by multiple worldviews. Opportunities for interdisciplinary learning in the English HE system are limited; associated primarily with postgraduate study or later undergraduate stages. This paper reports on an enhancement project that sought to engage first-year students with interdisciplinary learning. Drawing on data gathered from staff interviews, student focus groups and module enrolments, we examine drivers and barriers impacting on the planned curriculum transformation. Whilst drivers emerged from many directions (e.g. professional bodies, staff advocates), these were overwhelmed by the barriers–both administrative …

Implementing A New Emergency Department: A Qualitative Study Of Health Professionals' Change Responses And Perceptions, Nina Thórný Stefánsdóttir, Per Nilsen, Mette Bendtz Lindstroem, Ove Andersen, Byron J Powell, Tine Tjørnhøj-Thomsen, Jeanette Wassar Kirk

2020-Current year OA Pubs

BACKGROUND: The aim of the study is two-fold. It explores how managers and key employees at the Emergency Department (ED) and specialist departments in a university hospital in the Capital Region of Denmark respond to the planned change to a new ED, and how they perceive the change involved in the implementation of the new ED. The study investigates what happens when health professionals are confronted with implementation of policy that changes their organization and everyday work lives. Few studies provide in-depth investigations of health professionals' reactions to the implementation of new EDs, and particularly how they influence the implementation …

Focus, 2022, Winter, Andrews University

Focus

FOCUS (ISSN 1077-9345) is published quarterly, free of charge, for alumni and friends of Andrews University, an institution owned and operated by the Seventh-day Adventist Church.

Characterization Of Competitive Inhibitors Of Plasmodium Falciparum Cgmp-Dependent Protein Kinase**, Tyler Eck, Mariana Laureano De Souza, Melvin Delvillar, Kutub Ashraf, Rammohan R. Yadav Bheemanaboina, Ramappa Chakrasali, Tamara Kreiss, John J. Siekierka, David P. Rotella, Purnima Bhanot, Nina M. Goodey

Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works

Plasmodium falciparum cGMP-dependent protein kinase (PfPKG) is an enticing antimalarial drug target. Novel chemotypes are needed because existing inhibitors have safety issues that may prevent further development. This work demonstrates isoxazole-based compounds are potent ATP competitive inhibitors of PfPKG and discloses a new analogue in this series. Isoxazoles 3 and 5 had Ki values that are comparable to a known standard, 4-[2-(4-fluorophenyl)-5-(1-methylpiperidine-4-yl)-1H pyrrol-3-yl] pyridine. They also exhibited excellent selectivity for PfPKG over the human orthologue and the gatekeeper mutant T618Q PfPKG, which mimics the less accessible binding site of the human orthologue. The human orthologue's larger binding site volume is …

Meloxicam Versus Celecoxib For Postoperative Analgesia After Total Knee Arthroplasty: Safety, Efficacy And Cost, Amer Haffar, Yale A Fillingham, Leigham Breckenridge, D'Andrew Gursay, Jess H Lonner

Rothman Institute Papers

INTRODUCTION: Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used as part of multimodal analgesia in total knee arthroplasty (TKA). Selective cyclooxygenase (COX)-2 inhibitors (e.g., celecoxib) are believed to have fewer gastrointestinal (GI) adverse effects than nonselective NSAIDS. Meloxicam is less selective for COX-2 than celecoxib is and partially inhibits COX-1 at higher doses. Nonetheless, some surgeons prefer using nonselective NSAIDs because of their lower expense.

METHODS: Four thousand nine hundred ninety-four patients who underwent TKA between January 2015 and February 2020 and took either celecoxib (n = 3,174), meloxicam 15 mg/d (n = 1,819), or meloxicam 7.5 mg/d (n = 451) …

Before They Crash And Burn (Out): A Compassion Fatigue Resilience Model, Kerry A. Schwanz, Melissa Paiva-Salisbury

Journal of Wellness

Introduction: We propose a working model of compassion fatigue resilience by identifying compassion fatigue (CF) and compassion satisfaction correlates as potential targets for building resilience. Further, we explore focusing on pre-professionals as a method of primary prevention of CF.

Methods: The participants were 143 college students who completed self-report measures to assess current CF, self-care behaviors, self-care beliefs, self-esteem, frequency of helping behaviors, and exposure to others under extreme stress.

Results: Notably, hierarchical regression analyses (controlling for helping frequency and exposure to high stress individuals) suggested that self-care beliefs and self-care behaviors contributed to concurrent experiences of CF, through secondary …

Creating Positive Change In Areas Of Fragility, Katherine Carlman

UNH Today Archive

No abstract provided.

The Prospector, April 5, 2022, Utep Student Publications

The Prospector

Headline: Fashion Issue

Protein Tyrosine Phosphatase Receptor Δ Serves As The Orexigenic Asprosin Receptor, Ila Mishra, Wei Rose Xie, Juan C Bournat, Yang He, Chunmei Wang, Elizabeth Sabath Silva, Hailan Liu, Zhiqiang Ku, Yinghua Chen, Bernadette O Erokwu, Peilin Jia, Zhongming Zhao, Zhiqiang An, Chris A Flask, Yanlin He, Yong Xu, Atul R Chopra

Faculty, Staff and Student Publications

Asprosin is a fasting-induced glucogenic and centrally acting orexigenic hormone. The olfactory receptor Olfr734 is known to be the hepatic receptor for asprosin that mediates its effects on glucose production, but the receptor for asprosin's orexigenic function has been unclear. Here, we have identified protein tyrosine phosphatase receptor δ (Ptprd) as the orexigenic receptor for asprosin. Asprosin functions as a high-affinity Ptprd ligand in hypothalamic AgRP neurons, regulating the activity of this circuit in a cell-autonomous manner. Genetic ablation of Ptprd results in a strong loss of appetite, leanness, and an inability to respond to the orexigenic effects of asprosin. …

Association Between Non-Tea Flavonoid Intake And Risk Of Type 2 Diabetes: The Australian Diabetes, Obesity And Lifestyle Study, Mary D. Adu, Catherine P. Bondonno, Benjamin H. Parmenter, Marc Sim, Raymond J. Davey, Kevin Murray, Simone Radavelli Bagatini, Dianna J. Magliano, Robin M. Daly, Jonathan E. Shaw, Joshua R. Lewis, Jonathan M. Hodgson, Nicola P. Bondonno

Research outputs 2022 to 2026

Studies examining the association between flavonoid intake and measures of insulin resistance and β-cell dysfunction, as markers of type 2 diabetes (T2DM) across the adult lifespan, may provide insights into how flavonoids influence T2DM risk. This study examined the cross-sectional associations between flavonoid intakes, from dietary sources other than tea, and biomarkers of glucose tolerance and insulin sensitivity in adults aged 25 years and older participating in the Australian diabetes, obesity and lifestyle (AusDiab) study. Additionally, longitudinal associations between non-tea flavonoid intakes and incident T2DM over 12 years were explored. Eligible participants (n = 7675) had no previous history of …

Belmont University Covid Surveillance And Containment: An Evaluation Of Program Effectiveness, Morgan A. Lambrecht

DNP Projects

In the early days of the Coronavirus (COVID) pandemic, members of university communities faced elevated risk of contracting COVID because they live and work in congregate settings, with shared living and dining arrangements. By the Fall 2020 semester, with limited information regarding the transmission of COVID, a quick, but comprehensive strategy was needed to allow students to return to university campuses, while maintaining a safe environment for students, faculty, and staff. The purpose of this project was to determine the effectiveness of the COVID surveillance and containment measures implemented in the 2020/2021 academic year for the residential campus community at …

Covid-19 Vaccine Uptake Among College Students, Erin Hoening, Elizabeth Morse, David Phillippi, Krystal Huesmann

DNP Projects

Background: Public health strategies to improve COVID-19 vaccine uptake among college students living in residential communities varied, some universities opted to mandate COVID-19 vaccines while other universities opted to promote and influence the choice for vaccination.

Purpose: This descriptive, cross-sectional study examined the voluntary uptake of COVID-19 vaccines among residential students on a college campus in the southeastern U.S. that elected an evidence-driven health promotion strategy that included strong health promotion messaging coupled with coordinated efforts to make the vaccine accessible and appealing to students on campus.

Methods: Analysis of vaccine uptake was derived from campus electronic health records during …

Certified Clinical Nurse Leaders Not Hired Into The Formal Role: Job Title Survey And Systematic Review, Jacqueline Alexander Clavo-Hall

Dissertations

The purpose of this study is to answer the following questions: (1) To what extent do NHA CNLs report engaging in CNL competency-based activities in their current positions? (2) Does NHA CNLs' engagement in CNL competency-based activities vary by job titles? (3) What roles were certified CNLs enacting if they were not hired into officially titled CNL roles?

Genetic Evaluation For Hereditary Cancer Syndromes Among African Americans: A Critical Review, Ambreen Khan, Charles R Rogers, Carson D Kennedy, Ana Maria Lopez, Joanne Jeter

Department of Medical Oncology Faculty Papers

While hereditary cancer syndromes have been described and studied for centuries, the completion of the human genome project fueled accelerated progress in precision medicine due to the introduction of genetic testing in the 1990s, creating avenues for tailored treatments and medical management options. However, genetic testing has not benefited everyone equitably, with nearly all of the published work based on individuals of non-Hispanic White/European ancestry. There remains a gap in knowledge regarding the prevalence, penetrance, and manifestations of common hereditary cancer syndromes in the African-American population due to significant disparities in access and uptake of genetic testing. This review summarizes …

Self-Portraits For Social Change: Audience Response To A Photovoice Exhibition By Women With Disability, Diane Macdonald, Angela Dew, Karen Fisher Assoc Prof, Katherine Boydell

The Qualitative Report

Negative attitudes about and behaviours towards women with disability are harmful and exclusionary, contributing to poorer health, income, educational, and employment outcomes. Our study focused on what audiences learnt, felt, and did (what changed) after viewing self-portraits and stories by women with disability. We questioned whether a public exhibition of their artworks, created through photovoice methodology, could be an effective platform to provoke social change and increase inclusion for people with disability. We collected audience response to our exhibition to address a research gap and to provide an example for other photovoice researchers. We employed interpretive thematic analysis through a …

Qualitative Data Analysis For Health Research: A Step-By-Step Example Of Phenomenological Interpretation, Sue Monaro, Janice Gullick, Sandra West

The Qualitative Report

Phenomenological studies have been critiqued when analytic activities and intersection with the underpinning philosophy lack clarity. This methodological discussion paper describes data analysis in hermeneutic interpretive phenomenology. Data management strategies (transcript preparation, coding, philosophy application, tabling/concept maps, and Microsoft Word) and data analysis processes (reduction, display, and conclusion drawing/verification) are illustrated. Deconstruction, reconstruction, and reorganisation of themes/subthemes using hierarchical heading styles to populate the navigation pane and philosophical tenets acted as analytic hooks. This paper has outlined data analysis in hermeneutic interpretive phenomenology, including the use of MS Word and its functionality, which was supported by other data display strategies …

"Ana Yahanu Faqat": A Phenomenological Study On The Performance Character And Life Success, Saiful Amien, Punaji Setyosari, Nurul Murtadho, Sulton Sulton

The Qualitative Report

Everyone can achieve life success if they can fulfil the prerequisites. There is no dominant factor that determines success, but the strength of character can be an essential asset that is not in doubt. This study aims to explore the Yahanu character strengths in the phenomenon of achieving life success of three santri, graduates of the same pesantren (Islamic boarding school) in Indonesia. We design this research with a phenomenological approach. We collected the data through in-depth interviews, then transcribed it verbatim into a solid description, and analyzed it through descriptive-psychological phenomenological analysis procedures. The findings show that: (1) …

Designing To Attract In An Emerging Market: Applying Behavioural Reasoning Theory To South African Consumer Reactions To An Ultra-High Temperature Milk Product Line Extension, Elizabeth Kempen, Lorna Christie

Journal of Marketing and Consumer Behaviour in Emerging Markets

In the ultra-high temperature (UHT) milk category, parent brands introduce line extensions as innovative product designs to address the competitiveness in the market. However, not knowing if consumers will purchase the product results in uncertainty for the product design and marketing team. Using the behavioural reasoning theory, the purpose of this study was to explore South African consumers’ reasons for purchasing a UHT line extension that was designed to include the word ‘enriched’ and other extrinsic line extension attributes comprising product packaging design, country of origin and price. An exploratory-descriptive qualitative study was conducted using six focus groups involving milk …

Targeting The Nrf2/Ho-1 Antioxidant Pathway In Flt3-Itd-Positive Aml Enhances Therapy Efficacy, Sankaranarayan Kannan, Mary E Irwin, Shelley M Herbrich, Tiewei Cheng, Lanisha L Patterson, Marisa J L Aitken, Kapil Bhalla, M James You, Marina Konopleva, Patrick A Zweidler-Mckay, Joya Chandra

Faculty, Staff and Student Publications

Acute myeloid leukemia (AML) is a molecularly heterogenous hematological malignancy, with one of the most common mutations being internal tandem duplication (ITD) of the juxtamembrane domain of the fms-like tyrosine kinase receptor-3 (FLT3). Despite the development of FLT3-directed tyrosine kinase inhibitors (TKI), relapse and resistance are problematic, requiring improved strategies. In both patient samples and cell lines, FLT3-ITD raises levels of reactive oxygen species (ROS) and elicits an antioxidant response which is linked to chemoresistance broadly in AML. NF-E2-related factor 2 (NRF2) is a transcription factor regulating the antioxidant response including heme oxygenase -1 (HO-1), a heat shock protein implicated …

Development & Validation Of A Piv System For Obtaining Data From A Uasb Reactor, Camila D' Bastiani, Gerald Gallagher, David Kennedy, Anthony Reynolds

Conference Papers

Anaerobic digestion processes can generate energy in the form of biogas while treating organic wastewater. The efficiency of the treatment, and thus the generation of biogas, is closely linked to the type and design of the reactor, and the technology used. Granular anaerobic digestion technology offers advantages such as a higher loading rate and reduction of the space needed. However, the hydrodynamics inside this type of reactor can be complex due to the presence of solids (granules) and gas (biogas) phases along with the liquid phase (wastewater). This is one of the reasons why the study and optimization of reactors …

2022-04-05 Message From The President, Morehead State University. Office Of The President.

Staff Congress Records

A message sent by the President of Morehead State University to the campus community regarding policy changes to the mask mandate from April 5, 2022.

2022-04-05 Resolution On Confidentiality Agreements, Morehead State University. Faculty Senate.

Faculty Senate Records

A resolution placed before the Faculty Senate on April 7, 2022 regarding the administration's use of Confidentiality Agreements during the hiring of staff and faculty.

Maximising Access To Timely Trauma Care Across Population Of Karachi And Its Districts: A Geospatial Approach To Develop A Trauma Care Network, Muhammad Nabeel Ashraf, Mohammad Salman Khalil, Ahwaz Akhtar, Lubna Samad, Asad Latif

Department of Anaesthesia

Objectives: To develop and propose a cost-effective trauma care network for Karachi, Pakistan, by calculating maximum timely trauma care (TTC) coverage achieved with the addition of potential designated private and public level 1 and level 2 trauma centres (TCs).
Setting: A lower middle-income country metropolis, Karachi is Pakistan's largest city with a population of 16 million and a total of 56 hospitals as per government registry data.
Participants: 41 potential TCs selected using a two-level, contextually-relevant TC designation criteria adapted from various international guidelines.
Primary and secondary outcome measures: Maximum TTC coverage achievable with the addition of potential TCs. Proposed …

Program Review Report 4-5-22, Angela Brock

Program Review Committee

No abstract provided.