Digital Commons Network^™

Kenyon Collegian - April 28

The Kenyon Collegian

No abstract provided.

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

The Role Of Socio-Cultural Perspectives And Vaccine Misinformation On The Intention To Receive Covid-19 Vaccination In A Selected Sample Of Georgia Southern Students, Alyssa G. Love-Archey

Honors College Theses

The purpose of the study was to explore sociocultural influences on the intention to receive the Covid-19 vaccination and to measure which sociocultural factor had the greater influence: misinformation about the vaccine or specific cultural beliefs (religion and/or cultural practices) on vaccine intent in Georgia Southern students. An anonymous, exploratory survey was utilized to collect information on these constructs in two selected groups of students: those who had been vaccinated prior to taking the survey and those who had not been vaccinated prior to taking the survey. Subjects of the study were undergraduate, master’s degree, and doctoral students of the …

Stigma In Caring For Children With Emotional And Behavioral Disorders In The Student Nurse Community, Niesha D. Bell

Honors College Theses

Stigma is a heavily researched topic across many different specialties in the healthcare field. The experience of being stigmatized has negative effects on psychological health and the overall quality of life of those with mental health issues. It is common for healthcare professionals to encounter and interact with children with emotional and behavioral disorders, therefore for healthcare workers, the luxury of having a low level of understanding on this topic cannot be afforded. Healthcare professionals not only have a higher incidence of interacting with this population, but they also play a vital role in the treatment of conditions that this …

The George-Anne, Georgia Southern University

The George-Anne

• COMBATTING RAPE CULTURE
• Campus Life
• George-Anne Media Group Class of 2022
• Ukraine Crisis: Studying Abroad Amidst Total War
• GS remembers those lost in the first annual Eagles Call ceremony
• Rebecca's Cafe returns to Statesboro
• Jessica Batey
• REFELCTOR REWIND

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.

Thermodynamically Coupled Biosensors For Detecting Neutralizing Antibodies Against Sars-Cov-2 Variants, Jason Z Zhang, Laura A Vanblargan, Michael S Diamond, Et Al.

2020-Current year OA Pubs

We designed a protein biosensor that uses thermodynamic coupling for sensitive and rapid detection of neutralizing antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants in serum. The biosensor is a switchable, caged luciferase-receptor-binding domain (RBD) construct that detects serum-antibody interference with the binding of virus RBD to angiotensin-converting enzyme 2 (ACE-2) as a proxy for neutralization. Our coupling approach does not require target modification and can better distinguish sample-to-sample differences in analyte binding affinity and abundance than traditional competition-based assays.

India's Ban On Antimicrobial Fixed-Dose Combinations: Winning The Battle, Losing The War?, Giorgia Sulis, Richeek Pradhan, Anita Kotwani, Sumanth Gandra

2020-Current year OA Pubs

BACKGROUND AND OBJECTIVES: India, the country with the largest market availability of antimicrobial fixed-dose combinations (FDCs), banned certain antimicrobial FDCs in September 2018. Our objective was to examine the impact of Government ban on the sales of antimicrobial FDCs.

METHODS: The sales patterns of 14 of the 26 banned antimicrobial FDCs were analyzed using monthly private sector drug sales data from IQVIA (a comprehensive and nationally representative drug sales database) between January 2018 and December 2019. We carried out descriptive analyses to evaluate the trend in sales over time for banned and non-banned antimicrobial FDCs using cumulative sales volumes.

RESULTS: …

Sars-Cov-2 Is Associated With Changes In Brain Structure In Uk Biobank, Gwenaëlle Douaud, Soojin Lee, Fidel Alfaro-Almagro, Christoph Arthofer, Chaoyue Wang, Paul Mccarthy, Frederik Lange, Jesper L. R. Andersson, Ludovica Griffanti, Anderson M. Winkler

School of Medicine Publications

There is strong evidence of brain-related abnormalities in COVID-191,2,3,4,5,6,7,8,9,10,11,12,13. However, it remains unknown whether the impact of SARS-CoV-2 infection can be detected in milder cases, and whether this can reveal possible mechanisms contributing to brain pathology. Here we investigated brain changes in 785 participants of UK Biobank (aged 51–81 years) who were imaged twice using magnetic resonance imaging, including 401 cases who tested positive for infection with SARS-CoV-2 between their two scans—with 141 days …

Hospital Readmission In Alcohol Use Disorder Patients: The Role Of Anti-Craving Medications And Discharge Disposition, Jordan Calabrese, Jonathan Brown, Mashtura Hasan, Samuel Neuhut, Young Jo

Student Publications

Background: Alcohol use disorder (AUD) results in frequent hospital readmissions. Although the literature has shown the efficacy of anti-craving medications (ACM), they are infrequently prescribed upon discharge. The outcomes of discharge to substance use treatment facilities (STF) have also not been fully explored. This study seeks to determine the impact of ACM as well as discharge to STF on readmissions for people with AUD.

Methods: This retrospective case-control study analyzed encounters made within HCA Healthcare hospitals across the United States from 2016 to 2018 for adults with AUD. The case definition was the presence of ACM defined as acamprosate or …

Abiotic Disorders Of Tomatoes, Nick Volesky, Marion Murray, Sheriden M. Hansen, Maegen A. Lewis

All Current Publications

Monitoring tomato plants regularly from seedling to harvest allows for early detection of abnormal conditions. Although tomato plants can be attacked by a variety of living organisms (insects, mites, pathogens, vertebrates), nonliving (abiotic) conditions can cause just as much damage. Abiotic diseases in tomato plants can arise from nutrient deficiencies, temperature extremes, abnormal lighting, chemical application, changes in water uptake, mechanical damage, genetic mutations, and more. This guide will cover most of the abiotic disorders and diseases that can affect tomatoes in Utah.

Anti-Immigration Policy And Mental Health: Risk Of Distress And Trauma Among Deferred Action For Childhood Arrivals Recipients In The United States, Luz M. Garcini, Melanie M. Domenech Rodriguez, Alfonso Mercado, Michelle Silva, German Cadenas, Thania Galvan, Manuel Paris

Psychological Science Faculty Publications

Objective: This study examined the association between immigration legal status and distress from the announcement of the termination of the Deferred Action for Childhood Arrivals (DACA) program among individuals affected by this potentially traumatic event (PTE), along with identifying relevant risk factors.

Method: Participants (N = 233) affected by the termination announcement provided cross-sectional self-reports on distress from the announcement that was measured using the Impact of Events Scale-Revised.

Results: Of the participants, 40.7% met the clinical cutoff for distress from the PTE indicative of posttraumatic stress disorder. DACA recipients had significantly higher levels of distress from the PTE …

Acoustofluidics For Simultaneous Nanoparticle-Based Drug Loading And Exosome Encapsulation, Zeyu Wang, Joseph Rich, Nanjing Hao, Yuyang Gu, Chuyi Chen, Shujie Yang, Peiran Zhang, Tony Jun Huang

Faculty Publications

Nanocarrier and exosome encapsulation has been found to significantly increase the efficacy of targeted drug delivery while also minimizing unwanted side effects. However, the development of exosome-encapsulated drug nanocarriers is limited by low drug loading efficiencies and/or complex, time-consuming drug loading processes. Herein, we have developed an acoustofluidic device that simultaneously performs both drug loading and exosome encapsulation. By synergistically leveraging the acoustic radiation force, acoustic microstreaming, and shear stresses in a rotating droplet, the concentration, and fusion of exosomes, drugs, and porous silica nanoparticles is achieved. The final product consists of drug-loaded silica nanocarriers that are encased within an …

Editorial: Nutrition And Metabolism In School-Age Children, F-P Martin, J Pinkney, Jm Saavedra

Peninsula Medical School

No abstract provided.

A Computationally Efficient Clustering Linear Combination Approach To Jointly Analyze Multiple Phenotypes For Gwas, Meida Wang, Shuanglin Zhang, Qiuying Sha

Michigan Tech Publications, Part 1

There has been an increasing interest in joint analysis of multiple phenotypes in genome-wide association studies (GWAS) because jointly analyzing multiple phenotypes may increase statistical power to detect genetic variants associated with complex diseases or traits. Recently, many statistical methods have been developed for joint analysis of multiple phenotypes in genetic association studies, including the Clustering Linear Combination (CLC) method. The CLC method works particularly well with phenotypes that have natural groupings, but due to the unknown number of clusters for a given data, the final test statistic of CLC method is the minimum p-value among all p-values of the …

Influence Of Information Literacy And Information Use On Competence Of Community Health Practitioners In Ibadan, Nigeria, Iseoluwa Adedokun Mr

Library Philosophy and Practice (e-journal)

The effective gathering and transmission of information is essential to the standard of care provided for patients. Community Health practitioners have a responsibility to acquire and use information in order to be well informed and competently discharge their duties creditably.

The study is a descriptive survey that targeted305 community health practitioners from Primary Health Care centres in five selected Local Governments Area in Ibadan out of which 215 respondents were selected using random sampling technique.

The study revealed that the Community Health practitioners (CHP) in Ibadan needs information relating to health-related, primary healthcare, emergency situations, how to perform some minors …

Ischemic Infarction In Young Adults, Jaroslaw Janczy

Aurora GME

No abstract provided.

Dental Imaging And Odontogenic Disease, Bret Kravis

Aurora GME

No abstract provided.

Enpp1 Variants In Patients With Gaci And Pxe Expand The Clinical And Genetic Heterogeneity Of Heritable Disorders Of Ectopic Calcification., Douglas Ralph, Yvonne Nitschke, Michael A Levine, Matthew Caffet, Tamara Wurst, Amir Hossein Saeidian, Leila Youssefian, Hassan Vahidnezhad, Sharon F Terry, Frank Rutsch, Jouni Uitto, Qiaoli Li

Department of Medicine Faculty Papers

Pseudoxanthoma elasticum (PXE) and generalized arterial calcification of infancy (GACI) are clinically distinct genetic entities of ectopic calcification associated with differentially reduced circulating levels of inorganic pyrophosphate (PPi), a potent endogenous inhibitor of calcification. Variants in ENPP1, the gene mutated in GACI, have not been associated with classic PXE. Here we report the clinical, laboratory, and molecular evaluations of ten GACI and two PXE patients from five and two unrelated families registered in GACI Global and PXE International databases, respectively. All patients were found to carry biallelic variants in ENPP1. Among ten ENPP1 variants, one homozygous variant demonstrated uniparental disomy …

Vaccine Protection Against The Sars-Cov-2 Omicron Variant In Macaques, Abishek Chandrashekar, Adrianus C. M. Boon, Et Al.

2020-Current year OA Pubs

The rapid spread of the SARS-CoV-2 Omicron (B.1.1.529) variant, including in highly vaccinated populations, has raised important questions about the efficacy of current vaccines. In this study, we show that the mRNA-based BNT162b2 vaccine and the adenovirus-vector-based Ad26.COV2.S vaccine provide robust protection against high-dose challenge with the SARS-CoV-2 Omicron variant in cynomolgus macaques. We vaccinated 30 macaques with homologous and heterologous prime-boost regimens with BNT162b2 and Ad26.COV2.S. Following Omicron challenge, vaccinated macaques demonstrated rapid control of virus in bronchoalveolar lavage, and most vaccinated animals also controlled virus in nasal swabs. However, 4 vaccinated animals that had moderate Omicron-neutralizing antibody titers …

Evaluating The Potential Impact Of Ototoxicant Exposure On Worker Health, Cody Beaver

Theses

Occupational exposure to ototoxicants, substances that can cause hearing loss or exacerbate the impact of noise exposure, is a workplace hazard that is not well understood. Existing research generally agrees that some solvents and heavy metals may be ototoxic, but few studies have attempted to establish the impact of exposure to ototoxicants in the workplace. This study examined trends in workplace exposure to ototoxicants among workers in the United States by comparing exposure data collected by the Occupational Safety and Health Administration against worker hearing loss data provided by the Bureau of Labor Statistics for 2012 through 2019. The study …

Problematic Social Media Use In The Context Of Romantic Relationships: Relation To Attachment, Emotion Regulation, And Motivations For Use, Eleni Gogos

Theses

Social media is an increasingly popular form of connecting with others, especially among young adults, but problematic social media use (PSMU) has become a growing concern. Research has shown that people with anxious attachment styles and poor emotion regulation have a greater likelihood of having PSMU (Liu & Ma, 2019), but how social media usage might play a role in these relationships has not been well-studied. This research asked if the association between anxious attachment and PSMU will be affected by both emotion regulation and online social surveillance in romantic relationships as mediating influences. We utilized advanced mobile phone features …

Donor-Derived Multiple Leukemia Antigen-Specific T-Cell Therapy To Prevent Relapse After Transplant In Patients With All, Swati Naik, Spyridoula Vasileiou, Ifigeneia Tzannou, Manik Kuvalekar, Ayumi Watanabe, Catherine Robertson, Natalia Lapteva, Wang Tao, Mengfen Wu, Bambi Grilley, George Carrum, Rammurti T Kamble, Laquisa Hill, Robert A Krance, Caridad Martinez, Priti Tewari, Bilal Omer, Stephen Gottschalk, Helen E Heslop, Malcom K Brenner, Cliona M Rooney, Juan F Vera, Ann M Leen, Premal D Lulla

Faculty, Staff and Students Publications

Hematopoietic stem cell transplant (HSCT) is a curative option for patients with high-risk acute lymphoblastic leukemia (ALL), but relapse remains a major cause of treatment failure. To prevent disease relapse, we prepared and infused donor-derived multiple leukemia antigen-specific T cells (mLSTs) targeting PRAME, WT1, and survivin, which are leukemia-associated antigens frequently expressed in B- and T-ALL. Our goal was to maximize the graft-versus-leukemia effect while minimizing the risk of graft-versus-host disease (GVHD). We administered mLSTs (dose range, 0.5 × 107 to 2 × 107 cells per square meter) to 11 patients with ALL (8 pediatric, 3 adult), and observed no …

Perceived Roles, Benefits And Barriers Of Virtual Global Health Partnership Initiatives: A Cross-Sectional Exploratory Study, Lisa Umphrey, George Paasi, William Windsor, Grace Abongo, Jessica Evert, Heather Haq, Elizabeth M Keating, Suet Kam Lam, Megan S Mchenry, Carolyne Ndila, Charles Nwobu, Amy Rule, Reena P Tam, Daniel Olson, Peter Olupot-Olupot

Faculty, Staff and Students Publications

BACKGROUND: Virtual global health partnership initiatives (VGHPIs) evolved rapidly during the COVID-19 pandemic to ensure partnership continuity. However the current landscape for VGHPI use and preference is unknown. This study aimed to increase understanding of GH partners' perspectives on VGHPIs.

METHODS: From 15 October to 30 November 2020, An online, international survey was conducted using snowball sampling to document pandemic-related changes in partnership activities, preferences for VGHPIs, and perceived acceptability and barriers. The survey underwent iterative development within a diverse author group, representing academic and clinical institutions, and the non-profit sector. Participants from their professional global health networks were invited, …

Engaging Patients And Families In Developing, Implementing, And Evaluating Hospital At Home: A Canadian Case Study, Sean P. Spina Bsc(Pharm), Acpr, Pharmd, Fcshp, Taylor Hainstock Bhsc, Ma, Rounak Haddadi Bsc, Bhsc, Beth Bourke Bscn, Rn, Lisa Thompson Bsc, Elizabeth Borycki Rn Phd Facmi, Fcahs, Fiahsi, Jennifer Cartwright, David Forbes Bsc(Pharm), Mpa, Acpr, Bcps, Cte, Curtis K. Harder Bsc(Pharm), Acpr, Pharmd, Fcshp, Andre Kushniruk Phd, Facmi, Fcahs, Fiahsi, Tasha Mckelvey Bscn, Mha, Rn, Tara Mcmillan Bsc, Stephanie Menz Bsc, Bsp, Acpr, Katy Mukai Ba, Mpa, Michelle Riddle, Shauna Tierney Md, Ccfp, Melinda Zeron Mullins Md, Phd, Ccfp

Patient Experience Journal

The Hospital at Home (HaH) care model is naturally patient-centred, with improved patient and family experiences and outcomes firmly anchoring the innovative approach to care. Existing literature focuses largely on the health care and patient care outcomes of HaH; however, to date, none of the identified literature has reported on engaging patients and families in the development, implementation, or evaluation of the HaH model of care. A multi-stakeholder, Patient-Oriented Research team in Victoria, British Columbia, Canada engaged patients and family/friend caregivers (PFCs) across all components of the HaH program. Guided by best practices in patient and public engagement, the team …

Showcasing Patient And Public Involvement: Using Consultation, Collaboration And Co-Design To Shape A Respiratory Programme, Kate Strong, Elizabeth Williams, Jude Hancock Dr

Patient Experience Journal

The NHS is committed to working with patient groups and the public to co-design health services to ensure that lived experience is used to optimise service design and delivery. This case study describes and considers methodologies used by commissioners to meaningfully engage and collaborate with patient groups to co-design respiratory services in a region of England. Stakeholders agreed a two-stage approach to the patient and public involvement (PPI) for this specific project; an initial consultation with patient groups on existing services, to inform a collaborative co-design process for the new pathway. The full pathway was not commissioned, but elements of …

Virtual Cardiac Rehabilitation: A Rapid Shift In Care Delivery In Response To The Covid-19 Pandemic, Clare Koning, Brigitte Friesen, Justin Daigle, Anita Ytsma

Patient Experience Journal

Cardiac rehabilitation is an integral part of recovery from a critical cardiac life event. This preventative strategy involves exercise rehabilitation, education, lifestyle modification, and self-management coaching – preparing patients for lifelong changes. Prior to the COVID-19 pandemic, these activities were supervised by clinicians in-person, on hospital grounds, and in large groups. However, due to pandemic regulations in Canada imposed in March 2020, all in-person group activities were restricted. Within the first two months of the pandemic, almost half of cardiac rehabilitation services in Canada closed and half of their employees were deployed to other areas. To continue to provide patient …

From Liability To Asset: A Large Health System’S Approach To Transforming Hospital Food, Sven Gierlinger, Bruno Tison, Nicole Giammarinaro

Patient Experience Journal

Historically, hospitals are infamous for poor food quality. Valuing food as a tenant of health and well-being, Northwell Health, New York’s largest healthcare system, is transforming its hospital food program to become an asset and market competition differentiator. By focusing on structure, workforce, procurement and process, Northwell has improved patient experience performance “Quality of Food” by 61 percentile rank points within three years with minimal impact on budgetary cost.

Experience Framework

This article is associated with the Environment & Hospitality lens of The Beryl Institute Experience Framework (https://www.theberylinstitute.org/ExperienceFramework).

• Access other PXJ articles related to this lens.
• Access other …

Positively Waiting: Technology As The Preferred Distractor In A Pediatric Outpatient Setting, Timothy Ernest, Victoria Maddex, Arnaldo Mejias, Lindy Davidson, Donna Ettel-Gambino

Patient Experience Journal

Visiting any pediatric outpatient clinic as a child may be considered a stressful and anxiety-inducing experience. The literature suggests that positive distractions, such as pet therapy and single-user electronic devices, may aid in reducing anxiety and maximizing patient satisfaction throughout the patient’s experience at a pediatric outpatient clinic. The aim of this pilot quality improvement project was to determine which positive distractions patients experienced and whether single-user electronic loaner devices should be provided to patients at pediatric outpatient facilities. A quantitative causal comparative approach was utilized in identifying patient exposure to key positive distraction techniques that may significantly decrease anxiety. …

When Healthcare Leadership And Philanthropy Lead To An Improved Patient Experience: The Paul Lepsoe Music Initiative, Sara Olivier Rn Bscn Mn, Corianne Bell Ba Mus, Cheryl Jones Registered Psychotherapist, Mta, Phd, Jerry M. Maniate Md, M.Ed, Frcpc, Facp

Patient Experience Journal

Through an unprecedented collaboration between an academic acute tertiary care hospital (The Ottawa Hospital (TOH) and a community-based professional orchestra (Ottawa Symphony Orchestra (OSO), the Paul Lepsoe Music Initiative represented an innovative partnership focused on improving patient care via (a) the integration of live music in waiting areas of the hospital’s Cancer Center and (b) the creation of individualized music therapy interventions on the inpatient Palliative Care Unit. Patient, family, and volunteer/staff feedback further refined the intervention throughout the duration of the Initiative; a qualitative process that provided insight into the overall patient experience and opportunities for patients and families …