Digital Commons Network^™

Computational Design Of Β-Fluorinated Morphine Derivatives For Ph-Specific Binding, Nayiri Alexander, Makena Augenstein, Matthew Gartner

Student Scholar Symposium Abstracts and Posters

The opioid epidemic impacted over 12 million Americans in 2019. Although they are effective pain-relieving medications, they carry addictive and dangerous side effects. Opioids, like morphine, bind non-selectively in both central and peripheral tissues; however, dangerous side effects result from central activation. Inflamed conditions of injured tissues have a lower pH (pH=6-6.5) environment than healthy central tissue (pH=7.4). We aim to design a morphine derivative that binds selectively within inflamed tissue using computationally-based molecular extension and dissection techniques. Binding to the mu-opioid receptor (MOR) is dependent on protonation of the biochemically active amine group of morphine. Fluorination of a carbon …

Developmental Kindergarten Classroom Intervention For Spatial Relational Terms, Maggie Eising, Courtney Karasinski

Open Access Publishing Support Funded Articles

Purpose

Relational ability is a key attribute of language. Knowledge of relational terms, including spatial terms, can facilitate development of relational ability. Acquisition of spatial terms can be challenging and necessitates experience and input due to the abstractness of the concepts. Service delivery models for school-based speech-language pathologists (SLPs) are changing from traditional “pull-out” therapy to intervention in the classroom. Response to Intervention (RtI) and multi-tiered system of support (MTSS) frameworks have expanded SLPs’ roles to working with all children at-risk for academic difficulties.

Methods

Given the importance of spatial terms, and the changing roles and service delivery models for …

Pandemic And Post-Pandemic Fashion Consumer And Business Trends, Su Yun Bae

Visions in Leisure and Business

COVID-19 has had an impact on both consumers and businesses. It has shifted consumer preferences to enjoy nature more and be more aware of environmental issues than ever before. Many businesses suffered during the pandemic, but some thrived as consumer lifestyles and needs changed. This article looks at changes in the market and consumer behavior during the COVID-19 crisis as well as consumer and business trends following the epidemic. It primarily focuses on consumer positivity and sustainability, as well as a business emphasis on innovation, human capital, personalized consumer experience, and the importance of positivity, inclusivity, and diversity.

The Impact Of Fictional Characters On Political Beliefs: A Reception Analysis Of Arrow S5e13, Eastin Kandt

Honors College

Story has a strong power to influence, and in America’s current polarized climate, it is important to understand how it can influence politics. In Arrow S5E13, there are characters representing every side of the gun control debate in the wake of a mass shooting at city hall. This study uses interpretive communities theory to analyze two focus groups’ responses to this episode. The focus groups were composed solely of nine college students, six female and three male in total. The results determine that (1) political moderates appreciate the fair fictional representation of multiple political perspectives in fiction, (2) members of …

A Good Tax System: An Analytical Approach Of United States Taxation, Elijah Bruce Biedinger

Honors College

This paper is an attempt to look at the American tax code in a different way. Rather than analyzing the tax on economic impacts, or how it effects the rich or poor, it sets a definition of “good tax” and constantly puts the American tax code under the microscope to determine if it is a good tax or not. For simplicity the paper only looks at personal taxes on the federal level which includes: estate, excise, gift, income, and payroll tax. After a summery and analysis of each tax is completed on an individual level, this paper looks at the …

Young Adult Literature: The Past, The Present, And The Person, Kelsea Abston

Honors College

During the COVID-19 pandemic, many national and global issues have been brought to light such as the Taliban government takeover in Kabul, the Black Lives Matter movement, and the mental health crisis. By using the following three novels - The Fountains of Silence by Ruta Sepetys, Dear Martin by Nic Stone, and Turtles All the Way Down by John Green - intertwined with literary theories and pre-established research regarding the use of literature to facilitate discussion, this paper intends to show howYoung Adult literature can help readers - teens and adults alike - to understand the weight of such …

A Study To Investigate The Relationship Between Relationship Theories, Dependency, And Self-Esteem, Peyton Himango

Honors College

The purpose of this study was to investigate the correlation between relationship theories, dependency, and self-esteem. A Google form was sent through social media, peers, and family connections to survey individual’s responses to the Relationship Theories Questionnaire, Spouse-Specific Dependency Scale, and the Rosenburg Self-Esteem Scale. A total of 130 participants (mostly female, Caucasian, and Christian) responded to the survey. I predicted that relationship theories would positively correlate with dependency and negatively correlate with self-esteem. A high score on the Relationship Theories Questionnaire indicates a destiny theory of love (belief in having a soulmate or determined by destiny), while a low …

School Garden Programs, Food Pathways, And Environmental Justice: Modeling Ethical Frameworks To Reclaim The Value Of Care Work Through Education, Charlotte Borland '22

Honor Scholar Theses

No abstract provided.

If A Tree Falls In The Forest: Presidential Press Conferences And Early Media Narratives About The Covid-19 Crisis, Masha Krupenkin, Kai Zhu, Dylan Walker, David Rothschild

Business Faculty Articles and Research

Throughout the COVID-19 crisis, as we confronted questions about social distancing, masking wearing, and vaccines, public safety experts warned that the consequences of a misinformed population would be particularly dire due to the serious nature of the threat and necessity of severe collective action to keep the population safe. Thus, the media and the political elites (e.g., President of the United States) who possess the power to set the information agenda around COVID-19 bear a huge responsibility for the general welfare. Through automated text analysis of complete transcripts of national cable, network, and local news, we explore their narratives surrounding …

Healthcare Providers' Experiences With A Clinical Mentorship Intervention To Improve Reproductive, Maternal And Newborn Care In Mwanza, Tanzania, Kahabi Isangula, Columba Mbekenga, Tumbwene Mwansisya, Loveluck Mwasha, Lucy Kisaka, Edna Selestine, David Siso, Thomas Rutachunzibwa, Secilia Mrema, Eunice Pallangyo

School of Nursing & Midwifery, East Africa

Introduction: There is increasing evidence suggesting that clinical mentorship (CM) involving on-the-job training is one of the critical resources—friendly entry points for strengthening the knowledge and skills of healthcare providers (HCPs), which in turn facilitate the delivery of effective reproductive, maternal, and newborn health (RMNH) care. The article explores the experiences of HCPs following participation in the CM program for RMNH in eight districts of Mwanza Region in Tanzania.

Materials and Methods: A qualitative descriptive design employing data from midterm project review meetings and Key Informant Interviews (KIIs) with purposefully selected HCPs (mentors and mentees) and District Medical Officers (DMOs) …

The Control Strategies Of Brominated Organic Disinfection By-Products: Adsorption With Pre-Chlorination And Photodegradation, Cagri Utku Erdem

All Dissertations

Increasing water pollution, scarcity, and seasonal events force water treatment plants to improve existing treatment techniques and/or implement new methods to enhance drinking water treatment and comply with disinfection by-product (DBP) regulations. A limited number of studies examine the pre-chlorination prior to activated carbon (AC) adsorption for the removal of DBP precursors, and there are no comprehensive and representative treatment conditions in current literature. Although many studies investigated photodegradation of individual DBPs by low pressure ultraviolet (UV₂₅₄) light, there is still lack of information and limited understanding of photodegradation of total organic halogens and practical implications of UV …

Abstract #1182615: Panhypopituitarism Induced By Covid-19 Infection, Aseel Yaseen, Shiri Levy

Endocrinology Meeting Abstracts

Introduction: Coronavirus disease 2019 (COVID-19) infection has led to multiple endocrinopathies. We present a case of panhypopituitarism induced by COVID -19 infection.

Case Description: 76 yo male with history of type 2 diabetes, hypertension, and 1.5 cm stable, nonfunctioning, pituitary macroadenoma diagnosed in 2017 had multiple admissions for altered mental status and hyponatremia following COVID-19 infection in April 2020. Workup revealed low free T4 0.60 ng/dL (0.8-1.8), low random cortisol 1.8 mcg/dL(2.9-19.4), high prolactin 33.5 ng/mL (2-18), low total testosterone < 10 ng/dl (175-781), SHBG 32.7 nmol/L (13.3-89.5), and low gonadotropins. While hospitalized, he was diagnosed with pan-hypopituitarism and started on glucocorticoids and levothyroxine. Repeat MRI pituitary done after discharge, documented stability of the macroadenoma without hemorrhage. To date, the patient remains on glucocorticoid replacement and thyroid hormone replacement in stable state.

Discussion: Hypopituitarism from any etiology has an incidence of 4.2 per 100,000. Hormone replacement therapy remains the mainstay of treatment. …

Monitoring Sars-Cov-2 Risk With Co2. The Importance Of Ventilation, Masks, And Vaccinations., Preston Betz

Earth Sciences Theses and Dissertations

To assess airborne pathogen infection risk, concentrations of interior carbon dioxide and changes in relative humidity serve as proxies for human respiration products. Yanes and Yapp, 2010, demonstrated that interior air carbon dioxide concentrations and ¹³C/¹²C ratios display a two-component mixing relationship between respiration carbon dioxide which is highly concentrated (>100x atmospheric) in respiration air CO₂ at >40,000 ppm compared with ambient air (~410 ppm). In the absence of combustion carbon dioxide, the concentration of carbon dioxide, in an interior space, depends on the rate of respiration CO₂ addition relative to the amount of …

Clinical Pathways Leading To Antibiotic Initiation In Patients With Suspected Infection And Their Association With Delays And Mortality, X Han, C Lopez-Espina, P A. Verhoef, A Spicer, A Bhargava, L Schmalz, Matthew Sims, Alexandra Halalau, Nicholas Maddens, Aimee Espinosa

Conference Presentation Abstracts

Rationale: Delayed antibiotic therapy is associated with increased mortality in patients hospitalized with infection. The decision toinitiate therapy in patients with suspected infection is influenced by a variety of information, such as vital signs, and laboratoryresults. Identifying different patterns of events that lead to initiation is necessary to discover factors that could serve as targets forinterventions to expedite this process. We aimed to identify the most common sequences of events that precede antibioticordering and to quantify the time intervals between each event that contribute to antibiotic delays. Methods: This was aretrospective study of adult patients hospitalized at 4 community hospitals …

Performance Evaluation Of A Label Manufacturer Using Simulation Modeling, Joshua Holguin

Open Access Theses & Dissertations

Currently, the Supply Chain has been affected by freight prices, material scarcity, demand forecasting, port congestion, and digital transformation which are causing high lead times and delaying deliveries in all industries, but specifically in the labeling/printing industry. The industry is currently affected by the lack of new research improvements, optimization methodologies, supply chain disruptions, and technologies implementations within the label industry. Labeling /Printing industry has been out in business for more than 50 years, where labeling technologies such as Flexographic, Digital, and Die Cutting have advance in performance, effectiveness, complexity, and dependability over the last years. The implementation of a …

Making Aid Work: Assessing The Impact Of Regional Similarities On State Development Through A Transaction Costs Approach, Sophia Corinne Wozniak

Open Access Theses & Dissertations

This research seeks to discern the extent to which similarities between states involved in bilateral aid transfers impact the effectiveness of aid in catalyzing human development within the recipient state. Essentially, in this study I intend to understand if recipient states respond more positively to assistance when the donor state bears similar characteristics to the recipient. As a myriad of new donors emerge into the donor discussion, they bring with them unique cultural contexts, languages, religions, colonial heritages, geographic locations, and many other aspects which may distinguish them from the existing pool of donors.

Omicron Infection Milder In Nursing Home Residents, Robin L.P. Jump

Faculty Scholarship

No abstract provided.

The (Un)Just Use Of Transition Minerals: How Efforts To Achieve A Low-Carbon Economy Continue To Violate Indigenous Rights, Kate R. Finn, Christina A.W. Stanton

Colorado Environmental Law Journal

No abstract provided.

Community Choice Aggregators, Biomass Energy, And California's Just Transition: A Case Study Of Ab 843 And Responsible Biomass Procurement Principles, Shalini Swaroop Esq., Alexandrea Mcgee

Colorado Environmental Law Journal

No abstract provided.

Salary Roster, 2022 May, Eastern Michigan University

EMU Salary Reports

No abstract provided.

Complex Chromosomal Rearrangement Involving 15q11‐Q13 Interstitial Triplication And Duplication: A New Case Report Of Dysmorphic And Neuropsychiatric Features, Lekha Chilakamarri, Lizbeth Mellin

MEDI 9331 Scholarly Activities Clinical Years

Our patient is the first to encompass the full spectrum of reported features related to tetrasomy of the Prader–Willi Angelman Critical Region. She has a complex chromosomal rearrangement including an interstitial triplication reported in twelve cases till date and a rare interstitial duplication reported in only four cases till date.

Feasibility Of Acute Hematologic Toxicity Model-Based Patient Selection For Proton Beam Therapy, P Liu, X Cao, X Gao, S Shang, J Liu, Z Wang, Xuanfeng Ding

Conference Presentation Abstracts

Purpose or Objective To investigate the potential clinical benefit of utilizing IMPT to reduce acute hematologic toxicity for locally advanced nonsmall cell lung cancer (NSCLC) patients and explore the feasibility of a model-based patient selection approach via the normal tissue complication probability (NTCP). Materials and Methods Twenty patients with locally advanced NSCLC were enrolled.[ld1] Volumetric modulated arc photon therapy (VMAT) and intensity-modulated proton therapy (IMPT) plans were generated with a prescription dose of 60 Gy in 30 fractions. A wide range of cases with varied tumor size, location, stations of metastatic lymph nodes were selected to represent the general cancer …

Addressing Imposter Syndrome In First-Year College Students, Camille Mendoza

Capstone Projects and Master's Theses

Some first-year students may have feelings of Imposter Syndrome, where they feel self-doubt and fear that they are not qualified and worthy enough. Students experiencing Imposter Syndrome may not recognize their capabilities and may suffer from low self-esteem, anxiety, or depression. Given the potential impact of Imposter Syndrome on first-year students, colleges should provide training to those leaders on campus who work directly with first-year students so that Imposter Syndrome feelings can be minimized, and students can feel supported and included. To address Imposter Syndrome on college campuses, I developed a one-day training on Imposter Syndrome, symptoms of Imposter Syndrome, …

Children's Educational Online Workshop, Angelica Bautista

Capstone Projects and Master's Theses

The Greenfield Branch Library is one of the many Monterey County Free Libraries that offer multiple no-cost services to the community. The library’s mission is to serve its community and bring ideas, inspiration, information, and enjoyment to the community. Unfortunately, children are less likely to participate in educational activities when their families struggle financially. This is the case for many families during the pandemic and its aftermath. The Children's Educational Online Workshop aimed to be free academic support for families who cannot afford it elsewhere. My educational workshop took place on April 26 and April 27 both at four pm, …

Notice: Youth, Poc & Lgbtq+ Big Tobacco Wants You, Tucosha Lopez

Capstone Projects and Master's Theses

Breathe California of the Bay Area, Golden Gate, and Central Coast is a 501(c)3 non-profit that works with local communities to fight lung disease. This capstone project was developed for the Tobacco Control Program and addressed how Big Tobacco disproportionately targets youth, people of color, and LGBTQ+. Less awareness of tobacco-related issues, targeted marketing schemes, and individual susceptibility to negative health behaviors result in addiction, decreased physical/mental health, and increased negative behaviors. The project was a 45-minute educational resource video to be published on the Breathe California YouTube channel. It consists of topics about the warning signs of nicotine addiction …

Implementation Of Preemptive Dna Sequence-Based Pharmacogenomics Testing Across A Large Academic Medical Center: The Mayo-Baylor Right 10k Study, Liewei Wang, Steven E Scherer, Suzette J Bielinski, Donna M Muzny, Leila A Jones, John Logan Black, Ann M Moyer, Jyothsna Giri, Richard R Sharp, Eric T Matey, Jessica A Wright, Lance J Oyen, Wayne T Nicholson, Mathieu Wiepert, Terri Sullard, Timothy B Curry, Carolyn R Rohrer Vitek, Tammy M Mcallister, Jennifer L St Sauver, Pedro J Caraballo, Konstantinos N Lazaridis, Eric Venner, Xiang Qin, Jianhong Hu, Christie L Kovar, Viktoriya Korchina, Kimberly Walker, Harshavardhan Doddapaneni, Tsung-Jung Wu, Ritika Raj, Shawn Denson, Wen Liu, Gauthami Chandanavelli, Lan Zhang, Qiaoyan Wang, Divya Kalra, Mary Beth Karow, Kimberley J Harris, Hugues Sicotte, Sandra E Peterson, Amy E Barthel, Brenda E Moore, Jennifer M Skierka, Michelle L Kluge, Katrina E Kotzer, Karen Kloke, Jessica M Vander Pol, Heather Marker, Joseph A Sutton, Adrijana Kekic, Ashley Ebenhoh, Dennis M Bierle, Michael J Schuh, Christopher Grilli, Sara Erickson, Audrey Umbreit, Leah Ward, Sheena Crosby, Eric A Nelson, Sharon Levey, Michelle Elliott, Steve G Peters, Naveen Pereira, Mark Frye, Fadi Shamoun, Matthew P Goetz, Iftikhar J Kullo, Robert Wermers, Jan A Anderson, Christine M Formea, Razan M El Melik, John D Zeuli, Joseph R Herges, Carrie A Krieger, Robert W Hoel, Jodi L Taraba, Scott R St Thomas, Imad Absah, Matthew E Bernard, Stephanie R Fink, Andrea Gossard, Pamela L Grubbs, Therese M Jacobson, Paul Takahashi, Sharon C Zehe, Susan Buckles, Michelle Bumgardner, Colette Gallagher, Kelliann Fee-Schroeder, Nichole R Nicholas, Melody L Powers, Ahmed K Ragab, Darcy M Richardson, Anthony Stai, Jaymi Wilson, Joel E Pacyna, Janet E Olson, Erica J Sutton, Annika T Beck, Caroline Horrow, Krishna R Kalari, Nicholas B Larson, Hongfang Liu, Liwei Wang, Guilherme S Lopes, Bijan J Borah, Robert R Freimuth, Ye Zhu, Debra J Jacobson, Matthew A Hathcock, Sebastian M Armasu, Michaela E Mcgree, Ruoxiang Jiang, Tyler H Koep, Jason L Ross, Matthew G Hilden, Kathleen Bosse, Bronwyn Ramey, Isabelle Searcy, Eric Boerwinkle, Richard A Gibbs, Richard M Weinshilboum

Faculty, Staff and Student Publications

PURPOSE: The Mayo-Baylor RIGHT 10K Study enabled preemptive, sequence-based pharmacogenomics (PGx)-driven drug prescribing practices in routine clinical care within a large cohort. We also generated the tools and resources necessary for clinical PGx implementation and identified challenges that need to be overcome. Furthermore, we measured the frequency of both common genetic variation for which clinical guidelines already exist and rare variation that could be detected by DNA sequencing, rather than genotyping.

METHODS: Targeted oligonucleotide-capture sequencing of 77 pharmacogenes was performed using DNA from 10,077 consented Mayo Clinic Biobank volunteers. The resulting predicted drug response-related phenotypes for 13 genes, including CYP2D6 …

Acknowledgments, Christopher J. Sullivan

University of Richmond Law Review

No abstract provided.

Make Some Sense Of Scent Trademarks: The United States Needs A Graphical Representation Requirement, Gabrielle E. Brill

University of Richmond Law Review

When it comes to consumer loyalty, some businesses have decided to go beyond attracting the eyes. Why not keep customers via their nostrils? Accordingly, the scent marketing industry is booming. Jennifer Dublino, Vice President of Development at ScentWorld Events, remarks that “smell is one of the most unique of human senses. Scent enters the limbic system [of the brain] and bypasses all of the cognitive and logical thought processes and goes directly to the emotional and memory areas of the brain.” Companies like ScentAir have been created specifically to help stores design fragrances that best fit their image and objectives …

Pretextual Stops: The Rest Of The Story, J.E.B. Stuart Vi

University of Richmond Law Review

Pretextual stops made by law enforcement officers—stops aimed at serving some purpose other than the official reason for the stop—have received renewed attention in the public discourse following several high-profile law enforcement confrontations with people of color. Naturally, the conversations about pretextual stops have centered around their most horrid iteration: discriminatory stops made by bad cops. These stops are damaging to both motorists and officers, and conversations about them are undeniably important. But there is more to pretextual stops than the nefarious purposes attributed to them.

As a former police officer who regularly made pretextual stops for reasons entirely unrelated …

A Dynamic Co-Simulation Framework For The Analysis Of Battery Electric Vehicle Thermal Management Systems, T. Shelly, Justin A. Weibel, D. Ziviani, E. A. Groll

CTRC Research Publications

No abstract provided.