Digital Commons Network^™

Seven Staff Members Receive Outstanding Eeo Awards, Edwin B. Smith

University of Mississippi News

Individual UM employees and teams recognized for excellence in service categories, operations

Making The Case For The Accelerated Withdrawal Of Aducanumab, Peter J. Whitehouse

Faculty Scholarship

U.S. Food and Drug Administration-s (FDA) approval of aducanumab (Aduhelm® in the US) as a treatment for mild cognitive impairment of the Alzheimer type and Alzheimer-s disease has raised such major concerns about efficacy, safety, FDA processes, and regulatory capture that Biogen-s license to market this biologic should be immediately withdrawn. Aducanumab has not demonstrated benefit to patients, failed to meet regulatory guidelines, and is likely to cause both individual and societal harm.

Covid-19 Negatively Impacted Health And Social Relationships Among Working-Age Adults With Disabilities, Claire Pendergrast, Shannon M. Monnat

Population Health Research Brief Series

Activities of Daily Living (ADLs) are related to personal care and mobility. COVID-19 disrupted access to care for many working-age adults with ADL difficulties, potentially creating negative health and social impacts. This research brief shows that working-age adults (18-64) with ADL difficulty faced worse health and social impacts than their peers without ADL difficulty during the first year of the COVID-19 pandemic. The needs of people with disabilities must be prioritized in policy decisions to increase equity and reduce health disparities during the ongoing COVID-19 response and in future public health emergencies.

Design Of Self-Assembled Peptides For Wound Healing, Ka-Kyung Kim

Dissertations

According to the CDC, 15% of diabetic patients develop diabetic foot ulcers (DFU) and approximately 170,000 patients undergo non-traumatic amputation annually. DFU is a major complication of diabetes caused by non-healing full-thickness wounds through the dermis. The current treatments include blood sugar control, frequent debridement, offloading, moist wound care, infection treatment, and amputation. To achieve wound closure of DFU, appropriate wound care and antibiotic therapy are essential. Topical regimens include hydrocolloids, alginates, foam, silver-impregnated dressings, and hydrogels. Wound healing is a complex and dynamic interplay between the immune system, keratinocytes, and dermal cells (in case of cutaneous wound). Angiogenesis has …

Pilot Phase Results Of A Prospective, Randomized Controlled Trial Of Narrowband Ultraviolet B Phototherapy In Hospitalized Covid-19 Patients, Frank H. Lau, Catherine E. Powell, Giacomo Adonecchi, Denise M. Danos, Andrew R. Dinardo, Robert J. Chugden, Peter Wolf, Carmen F. Castilla

School of Medicine Faculty Publications

COVID-19 morbidity and mortality are driven by poor immune regulation. Narrowband ultraviolet B (NB-UVB) phototherapy is standard of care in a number of immune-dysregulated diseases. To assess the efficacy of NB-UVB phototherapy for improving COVID-19 outcomes in high-risk, hospitalized, we developed the Adaptive Photo-Protection Trial. This is a multi-center, prospective, double-blinded, randomized, placebo-controlled trial. The pilot phase results are reported here. Consecutive patients admitted with a positive COVID-19 PCR were screened for eligibility. Enrolled subjects were computer randomized 1:1 to NB-UVB or placebo phototherapy. Subjects were treated daily with escalating doses on 27% of their body surface area for up …

“You Keep Using That Word”: Why Privacy Doesn’T Mean What Lawyers Think, Joshua A.T. Fairfeld

Osgoode Hall Law Journal

This article explores how the need to define privacy has impeded our ability to protect it in law. The meaning of “privacy” is notoriously hard to pin down. This article contends that the problem is not with the word “privacy,” but with the act of trying to pin it down. The problem lies with the act of definition itself and is particularly acute when the words in question have deep-seated and longstanding common-language meanings, such as liberty, freedom, dignity, and certainly privacy. If one wishes to determine what words like these actually mean to people, definition is the wrong tool …

The Webbing Of Public Law: Looking Through Deportation Doctrine, Asha Kaushal

Osgoode Hall Law Journal

The process of deporting non-citizens is subject to judicial review under several fields of public law. These fields—criminal law, constitutional law, and administrative law—arc towards the protection of the individual. And yet, a series of judicial interpretations place deportees on the margins of that otherwise protective arc. This marginalization is principally explained by the relationships between the fields: The “webbing” of public law joins the fields of criminal law, constitutional law, and administrative law together. Reading deportation cases laterally across these fields reveals that they function as mutual referents for one another, providing assurance that some other field will offer …

Far Beyond Baker: Heuristics And The Inadequacy Of The Reasonable Apprehension Of Bias Analysis, Arash Nayerahmadi

Osgoode Hall Law Journal

When we consider bias in an adjudicative setting, we think about cases such as Baker v. Canada where the interviewing officer’s emphasis on the applicant’s number of children, economic status, and mental health is glaring. It is easy to become accustomed to thinking about bias in clear examples such as prejudice against people of a disadvantaged group. However, bias can also be subtly present in the subconscious mind, even when a person appears to be acting objectively. The development of cognitive psychology research has revealed that the mind relies on heuristics, or mental shortcuts, to make quick decisions. Heuristics research …

Rethinking Human-Local Wildlife Relations, Yin Chan

Critical and Creative Thinking Capstones Collection

The plight of suburban wildlife receives considerably less attention than that of exotic or endangered species despite facing similar threats due to the decline of their natural habitats as humans expand upon them. From the perspective of a reflective practitioner, this paper provides new avenues to rethink current views on human-local wildlife relations and answer some of the difficult questions surrounding the topic. The methodology of Action Research is employed to explore concepts relevant to human-local wildlife relations. A synthesized practical framework integrating Action Research with Permaculture Design is proposed to create models for mutually beneficial coexistence between local wildlife …

Exploring The Impact Of Stress On Healthcare Student Competency: A Cognitive Model For Self-Regulating Performance During High-Stakes Scenarios, Michael J. Teachey

Critical and Creative Thinking Capstones Collection

Stress and anxiety are part of healthcare and are experienced not only by patients but also by clinicians. This work explores an issue prevalent in healthcare education, outlining the detrimental effects of stress-induced anxiety on student performance during practical assessments. Included in this paper are the research and investigative details that elaborate on the process taken towards resolving the issue. Research conducted in the fields of education, law, and medicine is used to explore how these areas address stress with regard to performance. Through the various processes of research and engagement, this action research project uncovers the underlying issue of …

Writing To Learn: A Course Design And Educational Resources, Geoff Keston

Critical and Creative Thinking Capstones Collection

Higher education students write in many courses, but often as only a small part of a class and without guidance about how to use writing to learn. This paper describes the design of a dedicated course, Writing to Learn, in which students practice many genres and study the science of learning. A focused approach to using writing as a way to learn aims to give students extensive and diverse practice, which isn’t done in many published case studies. And making ideas from psychology, neuroscience, and the theory of pedagogy a part of the course content shows students why and how …

The Careful Educator, Linwood Jackson Jr.

Critical and Creative Thinking Capstones Collection

Inward balance is experienced when one is able to make sense of various thoughts and feelings conjured by experience. My time in the Critical & Creative Thinking program at the University of Massachusetts Boston has introduced me to a possible formula giving me an answer as to why such an inward balance is, and especially for educators, both so liberating and so necessary. With “philosophy” being a key part of the equation, the balance to be experienced is for educating in a way where former experience sheds light on present and future goals. Passing this experience to our students, allowing …

Building Constructive Interpersonal Communication Skills In Military Professionals: Generating A Culture Of Trust, April L. Baptiste Robertson

Critical and Creative Thinking Capstones Collection

Trust and open communication are interdependent and as a post 9/11 career Army leader, I have witnessed what appears to be the erosion of both within the military ranks. Military quality of life and mental health issues are on the rise, with compliance and prevention programs appearing to be less than impactful solutions. The resulting effects of which is a loss of trust and confidence in leadership. The research and findings presented within this synthesis strongly indicate that targeted training on interpersonal communication skills and counseling would simultaneously foster leader development and underpin a culture of trust and open communication. …

On A Mission: Examination Of Graduate Resources For Multicultural Women At The University Of Massachusetts Boston, Annmarie Mccluskey

Critical and Creative Thinking Capstones Collection

This paper discusses significant issues affecting Multicultural Women Graduate Students at the University of Massachusetts Boston, a Predominately White Institution, for creating a centralized graduate resources weblink on the Office of Graduate Studies website. The intervention seeks to address navigating gender and race inequalities that create a double bind experience of stress within a dominant academic culture that reinforces isolation, intersectional barriers, microaggressions, and pressure to assimilate to the dominant culture. Facilitation of this proposal will impact Multicultural Women Graduate Students, the Office of Graduate Studies, the Provost’s Office which oversees the OGS, and the entirety of the University of …

A Metacognitive Approach To Video Game Coaching, Timothy Brian Nuryadi

Critical and Creative Thinking Capstones Collection

This synthesis paper details my journey as an action researcher to evaluate the role of metacognition in acquiring, maintaining, and extending performance in the online video game Team Fight Tactics (TFT). Metacognitive skills contribute towards optimizing practice and strategic adaptability, which are fundamentals for improving performance in TFT. As a TFT coach, I created a theoretical model for video game coaching that focuses on developing metacognitive skills as a mean to improve TFT performance. This metacognitive approach to coaching is the intervention in my action research project that will be evaluated. I found that my model was able to help …

Revealing Attitude And Motivation Of Young Efl Learners Through Metaphor Analysis: Learning English In The Crisis Time, Yossy Sunda Permatasari, Sri Rachmajanti, Utari Praba Astuti

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

This study aimed to find out learners’ attitude and motivation toward online English learning during COVID-19 outbreak. Eight first graders were involved in an interview session to reveal their perspectives through metaphor. The results of metaphor analysis showed that the learners have low motivation and attitude although they tend to get good score in English subject. Due to many obstacles in its implementation, students, teacher, and parents hope that the English teaching and learning activities can be done face-to-face completely to result in effective learning process.

Integrating The Technology In Teaching And Learning Process Through Digital Media Creation As A Way To Improve Indonesian Eyl Teachers’ Competence, Shirly Rizki Kusumaningrum, Utami Widiati, Khoirul Anwar, Hernik Farisia

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Now that the spread of COVID-19 is still high and the teaching and learning process should be continued to be conducted at homes, but it seems that some teachers – in this case EYL teachers– are not ready to integrate various digital platforms. It is necessary for us to respond to the need of investigating technology readiness of English for young learners teachers in teaching during this COVID-19 pandemic. It is strongly important to reveal the teachers’ technology readiness as it plays vital role, especially during this pandemic —when the only thing that the teachers and the students can do …

A Global Experiment On Motivating Social Distancing During The Covid-19 Pandemic, Nicole Legate, Thuy Vy Nguyen, Netta Weinstein, Arlen Moller, Lisa Legault, Zahir Vally, Zuzanna Tajchman, Andras N. Zsido, Miha Zrimsek

Department of Psychology Faculty Scholarship and Creative Works

Finding communication strategies that effectively motivate social distancing continues to be a global public health priority during the COVID-19 pandemic. This crosscountry, preregistered experiment (n = 25,718 from 89 countries) tested hypotheses concerning generalizable positive and negative outcomes of social distancing messages that promoted personal agency and reflective choices (i.e., an autonomy-supportive message) or were restrictive and shaming (i.e., a controlling message) compared with no message at all. Results partially supported experimental hypotheses in that the controlling message increased controlled motivation (a poorly internalized form of motivation relying on shame, guilt, and fear of social consequences) relative to no message. …

A Systematic Review Of The Efficacy And Safety Of Fecal Microbiota Transplantation In The Treatment Of Hepatic Encephalopathy And Clostridioides Difficile Infection In Patients With Cirrhosis, Kyaw Min Tun, Annie S. Hong, Kavita Batra, Yassin Naga, Gordon Ohning

Department of Internal Medicine Faculty Research

The microbiome of the human gut and liver coexists by influencing the health and disease state of each system. Fecal microbiota transplantation (FMT) has recently emerged as a potential treatment for conditions associated with cirrhosis, such as hepatic encephalopathy and recurrent/refractory Clostridioides difficile infection (rCDI). We have conducted a systematic review of the safety and efficacy of FMT in treating hepatic encephalopathy and rCDI. A literature search was performed using variations of the keywords “fecal microbiota transplant” and “cirrhosis” on PubMed/MEDLINE from inception to October 3, 2021. The resulting 116 articles were independently reviewed by two authors. Eight qualifying studies …

Covid-19 Newsletter (Vol. 121), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.

For Art's Sake: An Exploration Of The Persistence Of Imposter Syndrome And Low-Self Confidence In Creative Fields, Mckinsey Carroll

University Honors Theses

Inspired by personal experiences as a graphic design student and those of my peers, this qualitative creative thesis discusses the prevalence of insecurity, imposter syndrome, and similar mental health struggles in creatives, and the ways in which these experiences or tendencies can inhibit us and stifle our creativity. Through my research, I learned that there are many ways in which graphic design as a field is uniquely affected by these issues, and that there exists a glaring need for conversation, particularly in academic spaces. This prompted the development of my personal interactive workbook titled "For Art's Sake" in which I …

Faithful Pilgrims, Teri Rizvi

Materials from the University of Dayton Magazine Website

The Marianists value the gifts of all people. Meet the 2022 Marianist Service Award recipients: Joe Owens and Michelle Tedford.

Nonprogrammers Are Building More Of The World's Software: A Computer Scientist Explains 'No-Code', Tam Nguyen

Materials from the University of Dayton Magazine Website

No abstract provided.

Optimization Of Polyhydroxyalkanoates (Phas) Bioplastic Production From Wastewater Activated Sludge, Bo Deng

Dissertations

Polyhydroxyalkanoate (PHA) is a biopolymer which has similar properties as fossil-fuel based plastic but also has capacity to biodegrade completely in the environment condition. This project aims to optimize the process to produce bioplastic PHA using activated sludge from wastewater. Specifically, five major research objectives are explored: (i) develop a quantification method of PHA by using Fourier-transform infrared spectroscopy (FTIR)F; (ii) improve the PHA production from mixed microbial cultures (MMC) by optimizing MMC; (iii) simulate the PHA production by using wastewater; (iv) evaluate the application of enzyme (alpha-amylase) in PHA production process; (v) market the investigation of wastewater produced PHA. …

A Bioactive Composite Scaffold Containing Zinc For Bone Tissue Engineering, Jennifer W. Moy

Dissertations

Non-union bone fractures occur during 5-10% of all bone fractures where the fracture is incapable of healing despite current surgical interventions with the use of bone grafts and graft substitutes. As an alternative, studies utilize growth factors and other biomolecules to differentiate mesenchymal stem cells into osteoblasts to aid in bone formation in vitro and in vivo studies. Zinc has known insulin-mimetic properties and are incorporated into multiple tissue engineering approaches to aid in osteogenesis, bone formation, and vascularization. In this work, mesenchymal stem cells (MSCs) were evaluated for the effect of zinc on osteogenesis. The supplementation of zinc in …

Piceatannol, A Dietary Polyphenol, Alleviates Adipose Tissue Loss In Pre-Clinical Model Of Cancer-Associated Cachexia Via Lipolysis Inhibition, Jonathan C. Kershaw, Bennett D. Elzey, Xiao Xuan Guo, Kee Hong Kim

Department of Food Science Faculty Publications

Cancer-associated cachexia (CAC) is the nutrition-independent loss of lean muscle and adipose tissues, and results in reduced chemotherapy effectiveness and increased mortality. Preventing adipose loss is considered a key target in the early stages of cachexia. Lipolysis is considered the central driver of adipose loss in CAC. We recently found that piceatannol, but not its analogue resveratrol, exhibits an inhibitory effect on lipolysis. The objective of this study was to investigate the role of piceatannol in cancer-associated lipolysis and cachexia-induced weight loss. Cancer cellinduced lipolysis in adipocytes was stimulated using cancer-conditioned media (CCM) or co-culture with human pancreatic cancer cells …

Piceatannol, A Dietary Polyphenol, Alleviates Adipose Tissue Loss In Pre-Clinical Model Of Cancer-Associated Cachexia Via Lipolysis Inhibition, Jonathan C. Kershaw, Bennett D. Elzey, Xiao-Xuan Guo, Kee-Hong Kim

Purdue University Libraries Open Access Publishing Fund

Cancer-associated cachexia (CAC) is the nutrition-independent loss of lean muscle and adipose tissues, and results in reduced chemotherapy effectiveness and increased mortality. Prevent- ing adipose loss is considered a key target in the early stages of cachexia. Lipolysis is considered the central driver of adipose loss in CAC. We recently found that piceatannol, but not its analogue resveratrol, exhibits an inhibitory effect on lipolysis. The objective of this study was to investigate the role of piceatannol in cancer-associated lipolysis and cachexia-induced weight loss. Cancer cell- induced lipolysis in adipocytes was stimulated using cancer-conditioned media (CCM) or co-culture with human pancreatic …

Longitudinal Patterns Of Suicidality Among Heroin Users In Johannesburg, South Africa: A Need For Suicide Screening And Intervention, Nirvana Morgan, Ellen-Ge Denton, Ugasvaree Subramaney, William Daniels, Tilman Steinert

Publications and Research

Objectives: The objective of the study was to longitudinally assess the outcomes and correlates of suicidal ideation and behavior (SIB) among heroin users who attended inpatient detoxification and psychosocial rehabilitation. SIB was assessed in 300 heroin users upon entry into inpatient detoxification (baseline) as well as 3-months (t1) (n = 252; 84%) and 9-months (t2) (n = 225; 75%) post treatment. Multivariable logistic regression was used to determine the demographic, clinical and treatment related factors that increased the risk for a high SIB score.

Results: From baseline to t1 there was a significant decrease in the proportion of …

Actions Against Racism: Bringing Together Trauma-Informed Practices, Social-Emotional Learning, And Racial Socialization To Combat Racism In Schools, Danielle R Hatchimonji, Kira Branch, Danika Perry, Tia N Barnes

Department of Pediatrics Faculty Papers

Racism is a social determinant of health with dire consequences for the health, education, and mental health of students of color. Thus, there is an urgent need to develop and test evidence-based strategies to combat racism in schools. In response to this need, our team has developed a multi-tiered school-based intervention to build capacity for combatting racism in educators, students, and families. The "Actions Against Racism" intervention synthesizes three evidence-based practices: trauma-informed practices, social-emotional learning (SEL), and racial socialization. The multiple tiers of intervention aim to cultivate skills for combatting individual and structural racism in educators, families, and students across …

Salivary Immunity Of Elite Collegiate American Football Players Infected With Sars-Cov-2 Normalizes Following Isolation, Joshua Granger, Eunhan Cho, Kevin Lindsey, Nathan Lemoine, Derek Calvert, Jack Marucci, Shelly Mullenix, Hollis O’Neal, Brian A. Irving, Neil Johannsen, Guillaume Spielmann

School of Medicine Faculty Publications

The impact of COVID-19 on systemic immunity in the general population has been well characterized, however the short-term effects of COVID-19 infection on innate salivary immunity in elite-level athletes are unknown. Therefore, this study aimed to determine whether elite college football athletes had altered salivary immunity following the CDC-recommended isolation post-SARS-CoV-2 infection. Salivary samples were obtained from fourteen elite football players who tested positive for SARS-CoV-2 (n = 14), immediately after CDC-recommended isolation (average days = 14 ± 2 days) and fifteen controls who remained uninfected with SARS-CoV-2. Biomarkers of innate salivary immunity (sIgA and alpha-amylase), antimicrobial proteins (AMPs, i.e., …