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Submittal Of Mixed Waste Landfill Annual Long-Term Monitoring & Maintenance Report, April 2021-March 2022 For Sandia National Laboratories/New Mexico, Epa Id Number Nm5890110518, June 2022, Sandia National Laboratories/Nm

Facilities-Units

The Department of Energy/National Nuclear Security Administration (DOE/NNSA) and Sandia National Laboratories /New Mexico (SNL/NM) personnel submitted the Mixed Waste Landfill (MWL) Annual Long-Term Monitoring and Maintenance Report for the April 2021 through March 2022 reporting period to the New Mexico Environment Department (NMED) in accordance with the requirements of Section 4.8.1 of the MWL Long-Term Monitoring and Maintenance Plan (LTMMP). The LTMMP became effective on January 8, 2014.

The MWL is a 2.6-acre Solid Waste Management Unit (SWMU 76) located in the north-central portion of SNL/NM Technical Area III that has undergone corrective action. As of March 13, 2016, …

Effect Of Educational Program On Parents' Caring For Their Children With Attention Deficit Hyperactivity Disorder, Sara Sayed Abdalla

Nursing

No abstract provided.

Longitudinal Manganese-Enhanced Magnetic Resonance Imaging Of Neural Projections And Activity, Taylor W. Uselman, Christopher S. Medina, Harry B. Gray, Russell E. Jacobs, Elaine L. Bearer

Pathology Research and Scholarship

Manganese-enhanced magnetic resonance imaging (MEMRI) holds exceptional promise for preclinical studies of brain-wide physiology in awake-behaving animals. The objectives of this review are to update the current information regarding MEMRI and to inform new investigators as to its potential. Mn(II) is a powerful contrast agent for two main reasons: (1) high signal intensity at low doses; and (2) biological interactions, such as projection tracing and neural activity mapping via entry into electrically active neurons in the living brain. High-spin Mn(II) reduces the relaxation time of water protons: at Mn(II) concentrations typically encountered in MEMRI, robust hyperintensity is obtained without adverse …

Clinical And Organizational Factors Associated With Mortality During The Peak Of First Covid-19 Wave: The Global Unite-Covid Study, Massimiliano Greco, Thomas De Corte, Ari Ercole, Massiomo Antonelli, Elie Azoulay, Giuseppe Citerio, Andy Conway Morris, Gennaro De Pascale, Frentisek Duska, Paul Ebers, Sharon Einav, Lui Forni, Laura Galarza, Armand R J Girbes, Giacomo Grasselli, Vitaly Gusarov, Alasdair Jubb, Jozef Kesecioglu, Andrea Lavinio, Maria Cruz Martin Delgado, Johannes Mellinghoff, Sheila Nainan Myatra, Marlies Ostermann, Marieangela Pellegrini, Pedro Povoa, Stefan Schaller, Jean-Louis Teboul, Adrian Wong, Jan J. De Waele, Maurizio Cecconi, Esicm Unite-Covid Investigators

Pathology Research and Scholarship

Purpose: To accommodate the unprecedented number of critically ill patients with pneumonia caused by coronavirus disease 2019 (COVID-19) expansion of the capacity of intensive care unit (ICU) to clinical areas not previously used for critical care was necessary. We describe the global burden of COVID-19 admissions and the clinical and organizational characteristics associated with outcomes in critically ill COVID-19 patients.

Methods: Multicenter, international, point prevalence study, including adult patients with SARS-CoV-2 infection confirmed by polymerase chain reaction (PCR) and a diagnosis of COVID-19 admitted to ICU between February 15th and May 15th, 2020.

Results: 4994 patients from 280 ICUs in …

Oral Health Status And Related Risk Factors Among Adolescents Attending High Schools In Khartoum, Sudan: A Cross-Sectional Study, Hajir Omara, Amal Elamin

All Works

Objectives Effective dental services must be based on reliable evidence of oral diseases status and treatment needs. The aim of this study was to assess oral health status and associated risk factors among adolescents attending high school in Khartoum, Sudan. Methods A school-based survey was conducted among 420 adolescents (13–18 years old). Participants completed a questionnaire about their socio-demographics and oral habits. They received clinical examination, assessing their oral health status using the World Health Organization (WHO) oral health survey for dentition and periodontal status; mean Decayed, Missing and Filled Teeth (DMFT), and Community Periodontal Index (CPI). Results High dental …

Dean's Update, June 2022, Jerry L. Nadler

SOM Dean's Research Newsletter

No abstract provided.

Translating Data Analytics Into Improved Spine Surgery Outcomes: A Roadmap For Biomedical Informatics Research In 2021, Jacob K. Greenberg, Ayodamola Otun, Zoher Ghogawala, Po-Yin Yen, Camilo A. Molina, David D. Limbrick, Randi E. Foraker, Michael P. Kelly, Wilson Z. Ray

2020-Current year OA Pubs

STUDY DESIGN: Narrative review.

OBJECTIVES: There is growing interest in the use of biomedical informatics and data analytics tools in spine surgery. Yet despite the rapid growth in research on these topics, few analytic tools have been implemented in routine spine practice. The purpose of this review is to provide a health information technology (HIT) roadmap to help translate data assets and analytics tools into measurable advances in spine surgical care.

METHODS: We conducted a narrative review of PubMed and Google Scholar to identify publications discussing data assets, analytical approaches, and implementation strategies relevant to spine surgery practice.

RESULTS: A …

Raising Anesthesiology Diversity And Antiracism: Launching A National Initiative, Matthew C. Wixson, Allison D. Mitchell, Scott D. Markowitz, Kate M. Malicke, Michael S. Avidan, George A. Mashour

2020-Current year OA Pubs

No abstract provided.

Joint Eanm, Snmmi And Iaea Enabling Guide: How To Set Up A Theranostics Centre, Ken Herrmann, Richard L Wahl, Et Al.

2020-Current year OA Pubs

The theranostics concept using the same target for both imaging and therapy dates back to the middle of the last century, when radioactive iodine was first used to treat thyroid diseases. Since then, radioiodine has become broadly established clinically for diagnostic imaging and therapy of benign and malignant thyroid disease, worldwide. However, only since the approval of SSTR2-targeting theranostics following the NETTER-1 trial in neuroendocrine tumours and the positive outcome of the VISION trial has theranostics gained substantial attention beyond nuclear medicine. The roll-out of radioligand therapy for treating a high-incidence tumour such as prostate cancer requires the expansion of …

Joint Eanm/Snmmi/Anzsnm Practice Guidelines/Procedure Standards On Recommended Use Of [18f]Fdg Pet/Ct Imaging During Immunomodulatory Treatments In Patients With Solid Tumors Version 1.0, E Lopci, R J Hicks, A Dimitrakopoulou-Strauss, L Dercle, A Iravani, R D Seban, C Sachpekidis, O Humbert, O Gheysens, A W J M Glaudemans, W Weber, R L Wahl, A M Scott, N Pandit-Taskar, N Aide

2020-Current year OA Pubs

PURPOSE: The goal of this guideline/procedure standard is to assist nuclear medicine physicians, other nuclear medicine professionals, oncologists or other medical specialists for recommended use of [

METHODS: In a cooperative effort between the EANM, the SNMMI and the ANZSNM, clinical indications, recommended imaging procedures and reporting standards have been agreed upon and summarized in this joint guideline/procedure standard.

CONCLUSIONS: The field of immuno-oncology is rapidly evolving, and this guideline/procedure standard should not be seen as definitive, but rather as a guidance document standardizing the use and interpretation of [

PREAMBLE: The European Association of Nuclear Medicine (EANM) is a …

Assessing Researchers' Capabilities, Opportunities, And Motivation To Conduct Equity-Oriented Dissemination And Implementation Research, An Exploratory Cross-Sectional Study, Ana A Baumann, Eva N Woodward, Rajinder Sonia Singh, Prajakta Adsul, Rachel C Shelton

2020-Current year OA Pubs

BACKGROUND: A recent paradigm shift has led to an explicit focus on enhancing health equity through equity-oriented dissemination and implementation (D&I) research. However, the integration and bidirectional learning across these two fields is still in its infancy and siloed. This exploratory study aimed to examine participants' perceived capabilities, opportunities, and motivations to conduct equity-oriented D&I research.

METHODS: We conducted an exploratory cross-sectional survey distributed online from December 2020 to April 2021. Participants were recruited at either D&I or health disparities-oriented conferences, meetings, through social media, or personal outreach via emails. Informed by the Capability, Opportunity, and Motivation Model (COM-B), the …

Synthesizing Pseudo-T2w Images To Recapture Missing Data In Neonatal Neuroimaging With Applications In Rs-Fmri, Sydney Kaplan, Dimitrios Alexopoulos, Jeanette K Kenley, Deanna M Barch, Jeffrey J Neil, Cynthia E Rogers, Aristeidis Sotiras, Christopher D Smyser, Et Al.

2020-Current year OA Pubs

T1- and T2-weighted (T1w and T2w) images are essential for tissue classification and anatomical localization in Magnetic Resonance Imaging (MRI) analyses. However, these anatomical data can be challenging to acquire in non-sedated neonatal cohorts, which are prone to high amplitude movement and display lower tissue contrast than adults. As a result, one of these modalities may be missing or of such poor quality that they cannot be used for accurate image processing, resulting in subject loss. While recent literature attempts to overcome these issues in adult populations using synthetic imaging approaches, evaluation of the efficacy of these methods in pediatric …

A Multi-Task Gaussian Process Self-Attention Neural Network For Real-Time Prediction Of The Need For Mechanical Ventilators In Covid-19 Patients, Kai Zhang, Siddharth Karanth, Bela Patel, Robert Murphy, Xiaoqian Jiang

Faculty, Staff and Student Publications

OBJECTIVE: The Coronavirus Disease 2019 (COVID-19) pandemic has overwhelmed the capacity of healthcare resources and posed a challenge for worldwide hospitals. The ability to distinguish potentially deteriorating patients from the rest helps facilitate reasonable allocation of medical resources, such as ventilators, hospital beds, and human resources. The real-time accurate prediction of a patient's risk scores could also help physicians to provide earlier respiratory support for the patient and reduce the risk of mortality.

METHODS: We propose a robust real-time prediction model for the in-hospital COVID-19 patients' probability of requiring mechanical ventilation (MV). The end-to-end neural network model incorporates the Multi-task …

A Special Message On Pride Month And A New Lgbtq+ Faculty Association, Selwyn M. Vickers Md

Browse All News

No abstract provided.

Extent Of Craniofacial Fungal Osteomyelitis In A Ketoacidotic Patient May Predict Optic Nerve Involvement: A Case Report, Jennifer Adams, Khalid Sheikh, Adam Bender-Heine

School of Medicine Publications

Introduction: Mucormycosis is an opportunistic mycosis common in poorly-controlled insulin dependent diabetic patients particularly with ketoacidosis. Fungal osteomyelitis is a life-threatening condition affectation of the nose and paranasal sinuses within the orofacial region.

Presentation of case: We present a 63-year-old diabetic male patient with maxillary mucormycotic osteomyelitis threatening his better seeing eye and review the clinical symptoms, relevant imaging, and management.

Discussion: We highlight a rare pattern of craniofacial fungal bone infection with maxillary and orbital involvement that ultimately spared the optic nerve. This case report offers the clinician a review of important clinical and diagnostic findings that …

Creating Safe Schools: An Exploratory Study Of Educator Perspective On Student Behavior And Restorative Practices In Schools Implementation, Rachel Danielle Vargas

Electronic Theses and Dissertations

Restorative practices in schools (RPS) is an Integrated Student Support process that many U.S. K-12 schools utilize to combat student behavior and racial disparities against students. Initial research suggests that RPS is a successful tool to drop suspension rates, create safe school environments, and help students stay engaged in school. However, there is not sufficient empirical evidence to support a successful implementation model, leading to mixed results and opinions about the effectiveness of RPS. The purpose of this study was to explore the program processes of RPS and determine effective implementation strategies that lead to successful student outcomes. Data were …

Influence Of The Human Lipidome On Epicardial Fat Volume In Mexican American Individuals, Ana C. Leandro, Laura F. Michael, Marcio Almeida, Mikko Kuokkanen, Kevin Huynh, Corey Giles, Thy Duong, Vincent P. Diego, Ravindranath Duggirala, Geoffrey D. Clarke, John Blangero, Joanne E. Curran

School of Medicine Publications

Introduction: Cardiovascular disease (CVD) is the leading cause of mortality worldwide and is the leading cause of death in the US. Lipid dysregulation is a well-known precursor to metabolic diseases, including CVD. There is a growing body of literature that suggests MRI-derived epicardial fat volume, or epicardial adipose tissue (EAT) volume, is linked to the development of coronary artery disease. Interestingly, epicardial fat is also actively involved in lipid and energy homeostasis, with epicardial adipose tissue having a greater capacity for release and uptake of free fatty acids. However, there is a scarcity of knowledge on the influence of plasma …

External Validation Of A Laboratory Prediction Algorithm For The Reduction Of Unnecessary Labs In The Critical Care Setting, Linda T Li, Tongtong Huang, Elmer V Bernstam, Xiaoqian Jiang

Faculty, Staff and Student Publications

BACKGROUND: Unnecessary laboratory tests contribute to iatrogenic harm and are a major source of waste in the health care system. We previously developed a machine learning algorithm to help clinicians identify unnecessary laboratory tests, but it has not been externally validated. In this study, we externally validate our machine learning algorithm.

METHODS: To externally validate the machine learning algorithm that was originally trained on the Medical Information Mart for Intensive Care (MIMIC) III database, we tested the algorithm in a separate institution. We identified and abstracted data for all patients older than 18 years admitted to the intensive care unit …

Recurrent Neural Network Models (Covrnn) For Predicting Outcomes Of Patients With Covid-19 On Admission To Hospital: Model Development And Validation Using Electronic Health Record Data, Laila Rasmy, Masayuki Nigo, Bijun Sai Kannadath, Ziqian Xie, Bingyu Mao, Khush Patel, Yujia Zhou, Wanheng Zhang, Angela Ross, Hua Xu, Degui Zhi

Faculty, Staff and Student Publications

BACKGROUND: Predicting outcomes of patients with COVID-19 at an early stage is crucial for optimised clinical care and resource management, especially during a pandemic. Although multiple machine learning models have been proposed to address this issue, because of their requirements for extensive data preprocessing and feature engineering, they have not been validated or implemented outside of their original study site. Therefore, we aimed to develop accurate and transferrable predictive models of outcomes on hospital admission for patients with COVID-19.

METHODS: In this study, we developed recurrent neural network-based models (CovRNN) to predict the outcomes of patients with COVID-19 by use …

Peripheral Blood Gene Expression Profiling Shows Predictive Significance For Response To Mycophenolate In Systemic Sclerosis-Related Interstitial Lung Disease, Shervin Assassi, Elizabeth R Volkmann, W Jim Zheng, Xuan Wang, Holly Wilhalme, Marka A Lyons, Michael D Roth, Donald P Tashkin

Faculty, Staff and Student Publications

OBJECTIVES: To characterise the peripheral blood cell (PBC) gene expression changes ensuing from mycophenolate mofetil (MMF) or cyclophosphamide (CYC) treatment and to determine the predictive significance of baseline PBC transcript scores for response to immunosuppression in systemic sclerosis (SSc)-related interstitial lung disease (ILD).

METHODS: PBC RNA samples from baseline and 12-month visits, corresponding to the active treatment period of both arms in Scleroderma Lung Study II, were investigated by global RNA sequencing. Joint models were created to examine the predictive significance of

RESULTS: 134 patients with SSc-ILD (CYC=69 and MMF=65) were investigated. CYC led to an upregulation of erythropoiesis, inflammation …

Inequalities In Antenatal Care In Ghana, 1998–2014, Abdul-Aziz Seidu, Joshua Okyere, Eugene Budu, Henry Ofori Duah, Bright Opoku Ahinkorah

College of Nursing Faculty Research and Publications

Background

In order to effectively and efficiently reduce maternal mortality and ensure optimal outcomes of pregnancy, equity is required in availability and provision of antenatal care. Thus, analysis of trends of socio-economic, demographic, cultural and geographical inequities is imperative to provide a holistic explanation for differences in availability, quality and utilization of antenatal care. We, therefore, investigated the trends in inequalities  in four or more antenatal care visits in Ghana, from 1998 to 2014.

Methods

We used the World Health Organization’s (WHO) Health Equity Assessment Toolkit (HEAT) software to analyse data from the 1998 to 2014 Ghana Demographic and Health …

Parent Health-Related Quality Of Life For Infants With Congenital Anomalies Receiving Neonatal Intensive Care, Krishna Acharya, Erin Rholl, Kathryn J. Malin, Margaret Malnory, Jonathan Leuthner, Steven R. Leuthner, Joanne Lagatta

College of Nursing Faculty Research and Publications

Objective

To examine factors associated with parent quality of life during and after neonatal intensive care unit (NICU) discharge among parents of infants with congenital anomalies admitted to the NICU.

Study design

This secondary analysis of 2 prospective cohort studies between 2016 and 2020 at a level IV NICU included parents of infants with major congenital anomalies receiving NICU care. The primary outcomes were parent health-related quality of life (HRQL) during the NICU stay and at 3 months post-NICU discharge.

Results

A total of 166 parent–infant dyads were enrolled in the study, 124 of which completed the 3-month follow-up interview. …

World Transit Research June 2022 Newsletter, Institute Of Transport Studies Monash University

World Transit Research Newsletter

No abstract provided.

Gene-Lifestyle Interactions In The Genomics Of Human Complex Traits, Vincent Laville, Yun J Sung, Karen Schwander, Mary F Feitosa, Aldi T Kraja, Mike Province, C Charles Gu, D C Rao, Et Al

2020-Current year OA Pubs

The role and biological significance of gene-environment interactions in human traits and diseases remain poorly understood. To address these questions, the CHARGE Gene-Lifestyle Interactions Working Group conducted series of genome-wide interaction studies (GWIS) involving up to 610,475 individuals across four ancestries for three lipids and four blood pressure traits, while accounting for interaction effects with drinking and smoking exposures. Here we used GWIS summary statistics from these studies to decipher potential differences in genetic associations and G×E interactions across phenotype-exposure-ancestry combinations, and to derive insights on the potential mechanistic underlying G×E through in-silico functional analyses. Our analyses show first that …

A Powassan Virus Domain Iii Nanoparticle Immunogen Elicits Neutralizing And Protective Antibodies In Mice, Ryan J. Malonis, George I. Georgiev, Denise Haslwanter, Laura A. Vanblargan, Georgia Fallon, Olivia Vergnolle, Sean M. Cahill, Richard Harris, David Cowburn, Kartik Chandran, Michael S Diamond, Jonathan R. Lai

2020-Current year OA Pubs

Powassan virus (POWV) is an emerging tick borne flavivirus (TBFV) that causes severe neuroinvasive disease. Currently, there are no approved treatments or vaccines to combat POWV infection. Here, we generated and characterized a nanoparticle immunogen displaying domain III (EDIII) of the POWV E glycoprotein. Immunization with POWV EDIII presented on nanoparticles resulted in significantly higher serum neutralizing titers against POWV than immunization with monomeric POWV EDIII. Furthermore, passive transfer of EDIII-reactive sera protected against POWV challenge in vivo. We isolated and characterized a panel of EDIII-specific monoclonal antibodies (mAbs) and identified several that potently inhibit POWV infection and engage distinct …

A Guide For Managing Patients With Stage I Nsclc: Deciding Between Lobectomy, Segmentectomy, Wedge, Sbrt And Ablation-Part 2: Systematic Review Of Evidence Regarding Resection Extent In Generally Healthy Patients, Frank C. Detterbeck, Vincent J. Mase, Andrew X. Li, Ulas Kumbasar, Brett C. Bade, Henry S. Park, Roy H. Decker, David C. Madoff, Gavitt A. Woodard, Whitney S Brandt, Justin D. Blasberg

2020-Current year OA Pubs

Background: Clinical decision-making for patients with stage I lung cancer is complex. It involves multiple options (lobectomy, segmentectomy, wedge, stereotactic body radiotherapy, thermal ablation), weighing multiple outcomes (e.g., short-, intermediate-, long-term) and multiple aspects of each (e.g., magnitude of a difference, the degree of confidence in the evidence, and the applicability to the patient and setting at hand). A structure is needed to summarize the relevant evidence for an individual patient and to identify which outcomes have the greatest impact on the decision-making.

Methods: A PubMed systematic review from 2000-2021 of outcomes after lobectomy, segmentectomy and wedge resection in generally …

Mangrove Growth Promotion By Endophytic Actinobacteria And Seaweed Extract, Ameera Khalfan Salem Alkaabi

Theses

In this study, I aimed to determine the impact of the application of a commercial seaweed extract (SWE) bio-stimulant and endophytic actinobacterial isolates on growth performance and endogenous hormonal levels of mangroves. Therefore, I isolated endophytic plant growth promoting (PGP) actinobacteria (PGPA) from mangrove roots; and evaluated their potential as biological inoculants on mangrove seedlings under greenhouse and open-field nursery conditions. Seven salt tolerant isolates had the ability to produce different levels of in vitro plant growth regulators (PGRs) and 1-aminocyclopropane-1-carboxylic acid (ACC) deaminase (ACCD), and to solubilize phosphorus. Accordingly, only one isolate, Streptomyces tubercidicus UAE1 (St), was …

Robust Detection Of Coronary Heart Disease Using Machine Learning Algorithms, Anas Haitham Domyati

Theses

Predicting whether or not someone will get heart or cardiac disease is now one of the most difficult jobs in the area of medicine. Heart disease is responsible for the deaths of about one person per minute in the contemporary age. Processing the vast amounts of data that are generated in the field of healthcare is an important application for data science. Because predicting cardiac disease is a difficult undertaking, there is a pressing need to automate the prediction process to minimize the dangers that are connected with it and provide the patient with timely warning. The chapter one in …

Performance Evaluation Of Glass-Fiber Reinforced Cement-Free Geopolymer Concrete, Mohammad Zuaiter

Theses

The alkali-activation of aluminosilicate materials produces a geopolymer binder that promises to be a sustainable replacement to cement in concrete. Yet, such concrete has experienced brittle behavior and poor resistance to cracking. As a means of improving its performance, this research assesses the feasibility of utilizing glass fibers in slag-fly ash blended geopolymer concrete for structural applications. A blend of slag and fly ash served as the binding material. Two types of glass fibers were used individually or as a hybrid combination. Type A and B glass fibers had similar properties but different lengths of 24 and 43 mm, respectively. …

The Constitutional (And Political) Safeguards Against Impeachment, Victoria Nourse

Missouri Law Review

Will the Trump impeachments inspire a flurry of future presidential impeachments? Will the second Trump impeachment, which occurred after the President left office, spur impeachments of lesser, former government officials? These and other questions emerged during the 2022 Missouri Law Review Symposium and on the Senate floor during the Trump impeachment trials. I have argued that we can make an educated prognosis about these possibilities based on constitutional structure. I called this argument the “political safeguards” of impeachment in my recent book, The Impeachments of Donald Trump: An Introduction to Constitutional Argument. What I called political safeguards, invoking the great …