Digital Commons Network^™

Verbal Inhibition Declines Among Older Women With High Fmr1 Premutation Expansions: A Prospective Study, Nell Maltman, Leann Dawalt, Jinkuk Hong, Audra Sterling, Elizabeth Berry-Kravis, Jessica Klusek, Marsha R. Mailick

Faculty Publications

The FMR1 premutation has been associated with difficulties in executive functioning, including verbal inhibition. However, little is known about the longitudinal profiles of verbal inhibition among FMR1 premutation carriers, particularly in women, and how individual factors such as aging and CGG repeat length may contribute to changes in verbal inhibition over time. The present study examined verbal inhibition performance (i.e., inhibition errors) on the Hayling Sentence Completion Task in a cohort of 92 women with the FMR1 premutation across two timepoints approximately three years apart. We examined the effects of age, CGG repeat length, and their interactions on verbal inhibition …

Annual Averages, Labor Force & Nonfarm Employment Estimates 2017-2021, Tennessee. Department Of Labor & Workforce Development.

Labor Force Estimates

No abstract provided.

A Systematic Review Of Substance Use And Substance Use Disorder Research In Kenya, Florence Jaguga, Sarah Kanana Kiburi, Eunice Temet, Julius Barasa, Serah Karanja, Lizz Kinyua, Edith Kamaru Kwobah

Anaesthesiology, East Africa

Objectives: The burden of substance use in Kenya is significant. The objective of this study was to systematically summarize existing literature on substance use in Kenya, identify research gaps, and provide directions for future research.

Methods: This systematic review was conducted in line with the PRISMA guidelines. We conducted a search of 5 bibliographic databases (PubMed, PsychINFO, Web of Science, Cumulative Index of Nursing and Allied Professionals (CINAHL) and Cochrane Library) from inception until 20 August 2020. In addition, we searched all the volumes of the official journal of the National Authority for the Campaign Against Alcohol & Drug Abuse …

Genomic Answers For Children: Dynamic Analyses Of >1000 Pediatric Rare Disease Genomes., Ana S A Cohen, Emily G. Farrow, Ahmed Abdelmoity, Joseph Alaimo, Shivarajan Manickavasagam Amudhavalli, John Anderson, Lalit R. Bansal, Lauren E. Bartik, Primo Baybayan, Bradley Belden, Courtney D. Berrios, Rebecca L. Biswell, Pawel Buczkowicz, Orion Buske, Shreyasee Chakraborty, Warren A. Cheung, Keith A. Coffman, Ashley M. Cooper, Laura A. Cross, Tom Curran, Thuy Tien T. Dang, Mary M. Elfrink, Kendra Engleman, Erin Day Fecske, Cynthia Fieser, Keely M. Fitzgerald, Emily Fleming, Randi N. Gadea, Jennifer L. Gannon, Rose N. Gelineau-Morel, Margaret Gibson, Jeffrey Goldstein, Elin Grundberg, Kelsee Halpin, Brian S. Harvey, Bryce Heese, Wendy Hein, Suzanne M. Herd, Susan Starling Hughes, Mohammed Ilyas, Jill Jacobson, Janda L. Jenkins, Shao Jiang, Jeffrey J. Johnston, Kathryn Keeler, Jonas Korlach, Jennifer Kussman, Christine Lambert, Caitlin E. Lawson, Jean-Baptist Lepichon, J Steven Leeder, Vicki C. Little, Daniel A. Louiselle, Michael Lypka, Brittany D. Mcdonald, Neil Miller, Ann Modrcin, Annapoorna Nair, Shelby H. Neal, Christopher M. Oermann, Donna M. Pacicca, Kailash Pawar, Nyshele L. Posey, Nigel Price, Laura M B Puckett, Julio Quezada, Nikita Raje, William J. Rowell, Eric T. Rush, Venkatesh Sampath, Carol J. Saunders, Caitlin Schwager, Richard M. Schwend, Elizabeth Shaffer, Craig Smail, Sarah E. Soden, Meghan Strenk, Bonnie Sullivan, Brooke Sweeney, Jade B. Tam-Williams, Adam Walter, Holly Welsh, Aaron M. Wenger, Laurel K. Willig, Yun Yan, Scott T. Younger, Dihong Zhou, Tricia N. Zion, Isabelle Thiffault, Tomi Pastinen

Manuscripts, Articles, Book Chapters and Other Papers

PURPOSE: This study aimed to provide comprehensive diagnostic and candidate analyses in a pediatric rare disease cohort through the Genomic Answers for Kids program.

METHODS: Extensive analyses of 960 families with suspected genetic disorders included short-read exome sequencing and short-read genome sequencing (srGS); PacBio HiFi long-read genome sequencing (HiFi-GS); variant calling for single nucleotide variants (SNV), structural variant (SV), and repeat variants; and machine-learning variant prioritization. Structured phenotypes, prioritized variants, and pedigrees were stored in PhenoTips database, with data sharing through controlled access the database of Genotypes and Phenotypes.

RESULTS: Diagnostic rates ranged from 11% in patients with prior negative …

Epistatic Interaction Between Rhg1‑A And Rhg2 In Pi 90763 Confers Resistance To Virulent Soybean Cyst Nematode Populations, Pawan Basnet, Clinton G. Meinhardt, Mariola Usovsky, Jason D. Gillman, Trupti Joshi, Qijian Song, Brian Diers, Melissa G. Mitchum, Andrew M. Scaboo

Biomedical Sciences

Key message

An epistatic interaction between SCN resistance loci rhg1-a and rhg2 in PI 90763 imparts resistance against virulent SCN populations which can be employed to diversify SCN resistance in soybean cultivars.

Abstract

With more than 95% of the $46.1B soybean market dominated by a single type of genetic resistance, breeding for soybean cyst nematode (SCN)-resistant soybean that can effectively combat the widespread increase in virulent SCN populations presents a significant challenge. Rhg genes (for Resistance to Heterodera glycines) play a key role in resistance to SCN; however, their deployment beyond the use of the rhg1-b allele has been …

Mapping The Restoration Of Degraded Peatland As A Field Of Research Area: A Scientometric Review, Samuel Obeng Apori, Douglas Mcmillan, Michelle Giltrap, Furong Tian

Articles

Degraded peatland reduced many ecosystem services such as water quality and quantity, biodiversity, carbon storage, climate regulations and other cultural benefits. Therefore, several initiatives for the restoration of degraded peatland (RDP) have been attempted to restore the ecosystem processes, productivity and services of the degraded peatland to its original natural condition. Notwithstanding the popularity of RDP research among researchers and industry practitioners, a quantitative technique to map a comprehensive survey of the intellectual core and the general body landscape of knowledge on RDP research does not exist. In this study, a scientometric analysis was employed to analyze 522 documents using …

Himmelfarb Library Liaison Letter - June 2022, George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Library Liaison Letters

No abstract provided.

Framing An Interprofessional Culture Of Learning Across Healthcare Programs, Loriann Helgeson, Smokey L. Fermin, Paul Werhane, Jonathan Hook

Occupational Therapy Faculty Scholarship

Innovation Summit for Health Professions Education Virtual Conference, June 23-24, 2022: Poster Presentation: Framing an interprofessional culture of learning across healthcare programs.

Framing An Interprofessional Culture Of Learning Across Healthcare Programs, Loriann Helgeson, Smokey Fermin, Jonathan Hook, Paul Werhane

Physical Therapy Faculty Scholarship

Innovation Summit for Health Professions Education Virtual Conference, June 23-24, 2022: Poster Presentation: Framing an interprofessional culture of learning across healthcare programs.

Galactic Accessibility: An Introduction To Interplanetary Human Rights Law Through Crip Legal Theory, Aj Link

Northern Illinois University Law Review

The possibilities within the realm of outer space and future space exploration have always been limitless. There has been renewed interest in space over the last decade, largely fueled by the private commercial space sector. As more and more people become interested in space and connected to the space industry, we must take care not to repeat the mistakes of the distant and recent past. Space should be accessible to all who wish to travel amongst the stars. We should not discriminate or bar individuals from going to space based on race, gender, gender identity or expression, nationality, religion, disability, …

Volume 42, Number 2, June 2022 Olac Newsletter, Laura Kane Mcelfresh, Jan Mayo, Meg Wang, Jay Weitz, Lisa Romano

OLAC Newsletters

Digitized June 2022 issue of the OLAC Newsletter.

Lindenwood Magazine, Spring 2022, Lindenwood University

Lindenwood Magazine (2017- )

Lindenwood University news magazine.

A Hill To Die On: Federal Court Reform In The 2020s, Daniel P. Suitor

Minnesota Law Review Vols. 106:2 onward (2021-present)

Is the Federal Judiciary broken and, if so, what can we do to fix it? To that end, Minnesota Law Review hosted its annual Symposium on March 25, 2022. Titled “A Hill to Die On: Federal Court Reform in the 2020s,” the event gathered some of the country’s leading thinkers, writers, and broadcasters studying the structure and operation of the Article III courts. Across three wide-ranging discussions, the Symposium’s participants attempted to answer the overarching inquiries by investigating the Supreme Court, lower federal courts, and the current events surrounding them.

Impact Of Publicity On The Development Of Library Services In Ifelodun Local Government Area Of Kwara State Nigeria, Mulikat Aliyu

Library Philosophy and Practice (e-journal)

The role of publicity in all facets of disciplines can not be overemphasized especially in promoting library services in the area of information gathering and dissemination regardless of the forms of the information – traditional or modern ways in this era of information and communication technology (ICT). This study examined the impact of publicity on the development of library services in Ifelodun Local government, Kwara state, Nigeria. The social descriptive survey research method was adopted; this is due to the fact that the population is large covering eighteen (18) wards and eight (8) districts. This type of research method is …

Information Literacy And Ict Skills Of Library Staff In Some Selected Federal Polytechnics In Nigeria, Lateef Alhaji Bello

Library Philosophy and Practice (e-journal)

This study assessed the information literacy and ICT skills of library staff in Federal Polytechnics in southwest Nigeria. The study adopted a survey research design and a total population of 154 which cut across six states in the Southwest geopolitical zone with five federal polytechnic. The study adopted stratified sampling techniques from which a sample size of 136 library staff was sampled. The major instrument used for data collection was questionnaire. A total of 154 copies of questionnaires were sent out, from which 136 copies were found to be valid and found fit for analysis. The data were analyzed using …

An Exercise-Inducible Metabolite That Suppresses Feeding And Obesity, Veronica L Li, Yang He, Kévin Contrepois, Hailan Liu, Joon T Kim, Amanda L Wiggenhorn, Julia T Tanzo, Alan Sheng-Hwa Tung, Xuchao Lyu, Peter-James H Zushin, Robert S Jansen, Basil Michael, Kang Yong Loh, Andrew C Yang, Christian S Carl, Christian T Voldstedlund, Wei Wei, Stephanie M Terrell, Benjamin C Moeller, Rick M Arthur, Gareth A Wallis, Koen Van De Wetering, Andreas Stahl, Bente Kiens, Erik A Richter, Steven M Banik, Michael P Snyder, Yong Xu, Jonathan Z Long

Children’s Nutrition Research Center Staff Publications

Exercise confers robust protection against obesity, type 2 diabetes, and other cardiometabolic diseases.1–5 However, the molecular and cellular mechanisms that mediate the metabolic benefits of physical activity remain unclear.6 Here we show that exercise stimulates production of Lac-Phe, a blood-borne signaling metabolite that suppresses feeding and obesity. Lac-Phe biosynthesis from lactate occurs in CNDP2+ cells including immune cells, epithelial cells, and mesenchymal stem cells localized to diverse organs. In diet-induced obese mice, pharmacological elevation of circulating Lac-Phe reduces food intake without affecting movement or energy expenditure. Chronic administration of Lac-Phe decreases adiposity and body weight and …

The Hypothalamus For Whole-Body Physiology: From Metabolism To Aging, Tiemin Liu, Yong Xu, Chun-Xia Yi, Qingchun Tong, Dongsheng Cai

Children’s Nutrition Research Center Staff Publications

Obesity and aging are two important epidemic factors for metabolic syndrome and many other health issues, which contribute to devastating diseases such as cardiovascular diseases, stroke and cancers. The brain plays a central role in controlling metabolic physiology in that it integrates information from other metabolic organs, sends regulatory projections and orchestrates the whole-body function. Emerging studies suggest that brain dysfunction in sensing various internal cues or processing external cues may have profound effects on metabolic and other physiological functions. This review highlights brain dysfunction linked to genetic mutations, sex, brain inflammation, microbiota, stress as causes for whole-body pathophysiology, arguing …

The Effect Of Reduced Cp, Synthetic Amino Acid Supplemented Diets On Growth Performance And Nutrient Excretion In Wean To Finish Swine, Caitlin E Vonderohe, Kayla M Mills, Shule Liu, Matthew D Asmus, Emily R Otto-Tice, Brian T Richert, Ji-Qin Ni, John Scott Radcliffe

Children’s Nutrition Research Center Staff Publications

Mixed sex pigs (n = 720) were placed in 12 rooms (Purdue Swine Environmental Research Building) to measure the effect of reduced crude protein (CP), amino acid (AA)-supplemented diets on growth and the carcass. Pigs were blocked by body weight (BW) and gender and allotted to room and pen (10 mixed-sex pigs/pen). Pigs were fed a nine-phase, wean-finish program. Control pigs consumed corn-soybean meal-distiller’s dried grains with solubles (DDGS) diets containing no to minimal (Met) synthetic AA. The 2X diet was formulated to meet the seventh most-limiting AA, and balanced using synthetic AAs to meet all AA needs. The …

Associations Between Adherence To The Dietary Approaches To Stop Hypertension (Dash) Diet And Six Glucose Homeostasis Traits In The Microbiome And Insulin Longitudinal Evaluation Study (Miles), Gautam Ramesh, Alexis C Wood, Matthew A Allison, Stephen S Rich, Elizabeth T Jensen, Yii-Der I Chen, Jerome I Rotter, Alain G Bertoni, Mark O Goodarzi

Children’s Nutrition Research Center Staff Publications

Background and aims: The DASH diet conveys protection against type 2 diabetes mellitus (T2D) Via plant-based and non-plant-based recommendations. Research has not identified which glucose homeostasis pathways are improved. We examined associations between adherence to a DASH diet and six glucose homeostasis traits, probing whether associations could be attributed to the plant-based (DASH-P) and/or non-plant based (DASH-NP) components.

Methods and results: We included data from 295 adults without T2D (age 59.3 ± 9.00 years; 63.46% non-Hispanic White and 36.54% African American, self-reported race ancestry) participating in the Microbiome and Insulin Longitudinal Evaluation Study (MILES). An oral glucose tolerance test (OGTT) …

Treatment Pearls: Management Of Physical Healthcare Needs In Patients With Mental Illness, Leslie W. Miles, Brandon Thatcher, Michael C. Thomas, Blaine Winters

Faculty Publications

Clinicians caring for persons with mental illness should be aware of increased mortality, physical problems, and health disparities in this population. This article provides a brief overview of physical health problems in the context of mental illness as well as those related to psychotropic medications, and discusses strategies to manage treatment effectively.

The Preliminary Development Of The North Dakota Sexual Violence Intervention Acceptability Measure, Raeann E. Anderson, Sara K. Kuhn, Anne E. Nickell

Psychology Student Publications

No abstract provided.

Regulating Personal Data Usage In Covid-19 Control Conditions, Mark Findlay, Nydia Remolina

Research Collection Yong Pung How School Of Law

Concern has been widely expressed about the potential for COVID-19 control technologies and resultant data sharing negatively impacting on civil rights, invading personal privacy, undermining citizen dignity through expansive data matching and ultimately providing opportunities for data use well beyond the brief of virus mitigation. This chapter offers suggestions regarding effective and inclusive regulatory responses when faced with extended surveillance, tracking/tracing, public/private provider data sharing and any breakdown in personal data firewalls, or otherwise conventional aggregated data deviations and distortion. In doing so, the chapter explores personal data usage in the context of COVID-19 as a regulatory enterprise. It addresses …

Filling A Niche? The Maize Productivity Impacts Of Adaptive Breeding By A Local Seed Company In Kenya, Samuel S. Bird, Michael R. Carter, Travis J. Lybbert, Mary Mathenge, Timothy Njagi, Emilia Tjernström

All Faculty Scholarship

This paper studies whether the absence of locally adapted seed varieties constrains the productivity and incomes of farm households residing in small, agro-ecological niches. We empirically examine the disruption of the maize seed market in Western Kenya that took place when public sector foundation breeding and social impact investment capital came together and allowed a local seed company to expand and target a niche area with adaptively-bred maize varieties. The three-year randomized controlled trial reveals that these seed varieties increased farmer yields and revenues, both for better-resourced farmers (who used non-adapted hybrids and fertilizer prior to the intervention) as well …

2022-June-01-Meet The Newest 1911 Society Members, University Marketing And Communication, East Tennessee State University

ETSU News

Named in commemoration of the year when ETSU was founded, the 1911 Society recognizes the university’s most notable graduates from undergraduate, graduate and professional programs. The selection committee evaluates applicants on academic achievement; sustained service; honors, awards, recognitions, publications and presentations; demonstrated leadership; work experience, such as study abroad, internships, externships and clinicals; and personal narratives.

The 1911 Society was established in 2020. Honorees receive special recognition and tartan stoles to wear during Commencement. Their contributions and accomplishments will be showcased on the 1911 Society wall located on the third floor of the D.P. Culp Student Center.

Pamela Avendaño-Rubi

Re-Directing The 50-Year-Long War On Drugs In The United States: Safe Injection Sites As The Necessary Weapons, Tessa Ptucha

Hofstra Law Review

No abstract provided.

Composition And Functional Potential Of The Human Mammary Microbiota Prior To And Following Breast Tumor Diagnosis, Courtney Hoskinson, Kelly Zheng, Jaelyn Gabel, Annie Kump, Rana German, Ram Podicheti, Natascia Marino, Leah T. Stiemsma

All Faculty Open Access Publications

Microbiota studies have reported changes in the microbial composition of the breast upon cancer development. However, results are inconsistent and limited to the later phases of cancer development (after diagnosis). We analyzed and compared the resident bacterial taxa of histologically normal breast tissue (healthy, H, n = 49) with those of tissues donated prior to (prediagnostic, PD, n = 15) and after (adjacent normal, AN, n = 49, and tumor, T, n = 46) breast cancer diagnosis (n total = 159). DNA was isolated from tissue samples and submitted for Illumina MiSeq paired-end sequencing of the V3-V4 region of the …

Beach Chair Versus Lateral Decubitus Surgical Positioning For Arthroscopic Anterior Shoulder Stabilization: A Retrospective Comparison Of Clinical And Patient-Reported Outcomes, Ryan W Paul, Sydney Streicher, Alim Osman, Chuka Ukekwe, Usman Zareef, Kevin B Freedman, Brandon J Erickson, Sommer Hammoud, Meghan E Bishop

Rothman Institute Papers

Background: Surgical positioning can affect both perioperative and postoperative complication rates. It is unclear whether beach-chair versus lateral decubitus positioning affects outcomes in patients undergoing arthroscopic anterior shoulder stabilization surgery.

Purpose: The purpose of this study was to compare recurrent instability, complications, and patient-reported outcomes between patients who underwent arthroscopic anterior shoulder stabilization in the beach-chair versus the lateral decubitus positions. It was hypothesized that recurrent instability, complications, and patient-reported outcomes would not be affected by surgical positioning.

Study Design: Cohort study; Level of evidence, 3.

Methods: The authors reviewed the medical records of patients who underwent shoulder stabilization ( …

Cwu Faculty Senate Minutes 6/01/22, Janet Shields

Faculty Senate Minutes

These are the official Central Washington University Faculty Senate minutes for the June 1, 2022, regular meeting.

Front Matter

Hofstra Law Review

No abstract provided.

#Freebritney: A Social Media Movement Shining A Light On Guardianship Abuse And Oversight, Nicole C. Palas

Hofstra Law Review

No abstract provided.