Digital Commons Network^™

Short-Term Survival And Prognostic Factors In Cervical Cancer Patients Requiring Hemodialysis: A Retrospective Cohort Study, Muhammad Trihatmowijoyo Bundjali, Maruhum Bonar Hasiholan Marbun, Wulyo Rajabto, Ikhwan Rinaldi, Hamzah Shatri, Dwi Lestari Partiningrum, Dadang Makmun, Pringgodigdo Nugroho, Sukamto Koesnoe, Pradana Soewondo

Kesmas

Cervical cancer is a common gynecological malignancy, particularly in developing countries, where it coexists with renal impairment in over one-third of patients. This disease typically presents acutely and progresses rapidly. Consequently, kidney replacement therapy, including hemodialysis (HD), is commonly required. To assess survival rates and associated factors, this retrospective cohort study analyzed the medical records of 252 cervical cancer patients who began HD across a three-month follow-up period. Kaplan–Meier analysis indicated a median short-term survival duration of 71.5 days (range: 7–90), with 1-, 2-, and 3-month survival rates of 56%, 51%, and 49%, respectively. Multivariate Cox regression identified post-HD systolic …

Factors Associated With Antiretroviral Therapy Adherence In Patients With Hiv At A Public Hospital In Central Jakarta, Indonesia, Kareena Sari Fatimah, Laily Hanifah, Chandrayani Simanjorang, Nayla Kamilia Fithri

Kesmas

Patients with human immunodeficiency virus (HIV) are required to take antiretroviral therapy (ART) to suppress the virus. However, suboptimal adherence remains a critical barrier that can lead to treatment failure and persistent transmission risks. This study aimed to identify factors associated with ART adherence in patients with HIV. This quantitative study with a cross-sectional design consisted of patients with HIV aged >18 years who received care at the voluntary counseling and testing clinic of a public hospital in Jakarta, Indonesia. Purposive sampling was used. This study used HIV care and ART overview forms as instruments. Data were analyzed using multiple …

Factors Affecting Irritant Contact Dermatitis Among Horticulture Farmers In Semarang District, Indonesia, Maria Goretti Catur Yuantari, Haikal Haikal, Dewi Susanna

Kesmas

Irritant contact dermatitis is a common condition among farmers, but its underlying causes remain poorly understood. This study aimed to identify factors associated with irritant contact dermatitis among horticulture farmers in Semarang District, Indonesia. A cross-sectional survey was conducted among 427 farmers using a validated, reliable structured questionnaire. The results indicated complaints of dermatitis related to contact with irritants. Data were analyzed using the Chi-square test and logistic regression. Analysis revealed that sex, personal hygiene habits, education level, and the number of pesticide types used were significantly associated with irritant contact dermatitis. Female farmers were less likely to develop irritant …

Patterns Of Tobacco Marketing And User Engagement On Social Media In Indonesia: Challenges For Digital Public Health, Resti Yulianti Sutrisno, Nopryan Ekadinata, Sutantri Sutantri, Dinasti Pudang Binoriang, Enrico Aditjondro, Rachfiansyah Rachfiansyah, Yosef Rabindanata, Silvia Dini, Rebecca Perl, Riska Rachmawati, Bertha Tesma Wulandari, Dianita Sugiyo

Kesmas

Large-scale tobacco marketing on social media has resulted in widespread population-level exposure, particularly in Indonesia, which faces growing challenges in digital public health. This study aimed to assess the associations between platform type and marketing tactics and identify correlations of user engagement. An analytical cross-sectional study was conducted using secondary data from the Tobacco Enforcement and Reporting Movement (TERM), collected from January 2022 to August 2023. A total of 21,255 tobacco marketing posts from social media were analyzed. Platform–tactic associations were examined using Chi-square tests, and multivariable Poisson regression was used to identify factors associated with user engagement. The findings …

Low-Dose Prophylaxis Versus On-Demand Treatment For Children With Severe Hemophilia A In Indonesia: A Conceptual Model, Levina Chandra Khoe, Nur Atika, Dhia Ticha Pertiwi, Septiara Putri

Kesmas

Hemophilia A is a rare bleeding disorder caused by a deficiency of clotting factor VIII, leading to recurrent bleeds, joint damage, and disability. Low-dose prophylaxis has been shown to achieve better clinical outcomes than on-demand treatment in reducing bleeding frequency. However, in Indonesia, access and affordability remain key challenges. This study aimed to develop a conceptual model for conducting a health economic evaluation of low-dose prophylaxis treatment for children with severe hemophilia A in Indonesia. This study followed the ISPOR-SMDM Modeling guidelines, outlining two-stage processes: conceptualization of the clinical problem and model development. A systematic literature review was conducted to …

Differential Response Of Finger Millet Accessions To Contrasting Saline Water Levels And Irrigation Regimes Under Desert Conditions, Abidemi Talabi, Nhamo Nhamo, Sumitha Thushar, Prashant Vikram, Hifzurrahman Rahman, Mohammed Shahid, Neeru Sood, Malavika Sudheer, Dheeraj Thikkamaneni, Amna Almarri, Fatma Alsaffar, Deep Galani, Moyeez Alam, Sonia Goel, Rakesh K. Singh

All Works

Water salinity and scarcity constitute major limitations to crop production in arid and semi-arid regions. Introduction of nutritious and stress-tolerant underutilized crops is a promising approach for dietary enrichment, cropping system diversification, remediation of marginal and degraded lands, and building climate resilience. The primary objectives of this study were to investigate the effect of water salinity and managed water-deficit stress on grain and fodder yield, identify multi-trait ideotypes, and validate the stability and genetic gain in finger millet ideotypes over a 2-year period. A total of 80 finger millet accessions were evaluated under fresh water (0 dS/m) and two saline …

Comparing Ckd Populations With T1d And T2d: A Perspective Based On The Fine-One And Fidelity Populations, Hiddo J L Heerspink, Janet B Mcgill, Et Al.

2020-Current year OA Pubs

Chronic kidney disease (CKD) is a common comorbidity of both type 1 diabetes (T1D) and type 2 diabetes (T2D) and is associated with increased mortality, end-stage kidney disease and cardiovascular disease risk. Despite standard-of-care treatment with renin-angiotensin system inhibitors added to blood pressure and glycaemic control, people with CKD and T1D have a residual risk of CKD progression. Advances in therapeutic management have been limited over the past 3 decades, especially compared with CKD in T2D, for which new treatment options have emerged in the last 5 years. In this review article we discuss the similarities and differences between T1D …

Navigating Compliance: Higher Education Leadership Strategies Amid Federal Government Dei Mandates, Patricia Henry

Economics Faculty Publications

Executive Order 14173 (Ending Illegal Discrimination and Restoring  Merit-Based Opportunities) has contributed to reshaping the policy  environment for marginalized populations including women,  communities of color, LGBTQ+ individuals, and people with disabilities  on university campuses. There is limited scholarly research exploring  how qualitative empirical studies probe into how higher education  leaders are navigating compliance with federal diversity, equity, and  inclusion (DEI) mandates amid heightened political and legal scrutiny  in the United States. Grounded in Viewpoint Discrimination Theory,  guided by Inclusive and Transformational Leadership frameworks, this  empirical study employs a multiple-case design integrating data from  scholarly literature, policy implementation analysis, institutional policy …

What Constitutes Risk In Implementation Research? Perspectives From A Qualitative Key-Informant Study, Emmanuel K Tetteh, Gifty Aboagye-Mensah, Nwaliweaku Anidi, Elvin H Geng, Byron J Powell, Enola K Proctor, Mark D Huffman, Alison L Antes

2020-Current year OA Pubs

BACKGROUND: As implementation research increasingly occurs within routine care settings, determining what constitutes minimal risk is critical to ensuring that ethical oversight is appropriate and proportional. Current regulatory definitions often do not reflect the unique features of implementation studies, including implementation strategy-related risks and system-level effects. Yet, little empirical evidence exists on how researchers themselves interpret minimal risk in this context.

METHODS: We conducted semi-structured qualitative interviews with 11 key informants, including investigators with experience in domestic and global implementation research. Participants were recruited through purposive sampling. Interviews explored how participants interpret the concept of minimal risk, identify risk-related concerns, …

Managing State-Owned University Student Dormitories In The Philippines: The Role Of Service Quality, Marc Immanuel G. Isip

Journal of Public Affairs and Development

State-subsidized student housing is generally left undeveloped, and only a few efforts focus on evaluating and improving service quality and living accommodation satisfaction in state-owned/managed dormitories in a sustainable, strategic manner. These student housing services are threatened by limited government funding and the challenges posed by the post-pandemic period. Inflation has prompted an increase in dormitory fees, but services remain generally affordable; however, higher fees have raised expectations for service quality. This paper aims to investigate the role of service quality in state-owned/managed university student housing services and explore how it influences residents’ satisfaction with living accommodations. Using Partial Least …

Elixhauser Comorbidity Index To Predict Perioperative Bleeding And Adverse Spine Surgery Outcomes, Mitchell K. Ng, Michael A. Mont, Mosadoluwa Afolabi, Prathiksha N V, Amitha Kumar, Stephen S. Johnston

Rothman Institute Papers

Introduction: As spine surgery volume continues to grow, ensuring patient safety and minimizing complications are increasingly critical. Disruptive bleeding—defined as hemorrhagic events requiring clinical intervention—is a significant perioperative challenge. This study aimed to: (1) quantify disruptive bleeding incidence; (2) evaluate associations between patient demographics, Elixhauser Comorbidity Index (ECI), and bleeding risk; and (3) assess the impact of disruptive bleeding on mortality, ventilator use, length of inpatient stay, 90-day readmissions, and inpatient costs. Methods: A nationwide healthcare database was used to identify patients who underwent spine surgery in 2019. Patients were subdivided by the Elixhauser Comorbidity Index (ECI) from 0 to …

Reporting Workplace Violence: Why Is It A Challenge?, Rebekah Powers, Carol Boswell

Creating Healthy Work Environments (CHWE)

The Occupational Safety and Health Administration (OSHA, n.d.) defines workplace violence to include "any act or threat of physical violence, harassment, intimidation, or other threatening disruptive behavior that occurs at the work site.” Workplace violence is a developing challenge within health care settings following the adversities encountered with behavioral issues acknowledged after the pandemic. Workplace violence includes physical episodes, verbal episodes, threats, and sexual harassment experiences, yet remains underreported (NIOSH, 2020). Nurses and nurse aides are two groups who are at the highest risk of becoming victims of violence due to their involvement with direct patient care. An acute care …

Comparison Of Ventilation Support During Laser Treatment Of Retinopathy Of Prematurity, Jason Peng, Raghav Taneja, Barry N. Wasserman, Krystal Hunter, Vineet Bhandari, Alla Kushnir

Wills Eye Hospital Papers

Highlights: What are the main findings? Preterm infants undergoing ROP laser surgery with routine elective intubation had significantly longer durations of post-operative mechanical ventilation. Routine intubation during this procedure did not improve short-term clinical outcomes, such as overall hospital length of stay or timing of laser intervention in the infant’s life. What are the implications of the main findings? Routine intubation strategies may unnecessarily increase exposure to mechanical ventilation without improving clinical outcomes. Standardization of perioperative intubation practices across hospitals may be needed to optimize respiratory support in this vulnerable population. Objective: To compare respiratory outcomes between infants undergoing retinopathy …

Engineering Human Microphysiological Models To Investigate Bacterial Extracellular Vesicle–Driven Endothelial And Blood–Brain Barrier Dysfunction, Louis P. Widom

Theses

Pathogenic bacterial extracellular vesicles (BEVs) are nanoscale particles derived from bacteria that contain pro-inflammatory cargo. During bacterial infections, BEVs provoke the host inflammatory response and may cause widespread damage. Furthermore, antibiotic treatment can boost BEV production and thereby increase the number of toxic signals traveling through the circulatory system. This is especially dangerous in brain blood vessels since evidence suggests that BEVs may destabilize the protective blood–brain barrier (BBB), resulting in neuroinflammation associated with cognitive decline and development of neurological disorders. Our understanding of BEV interactions with the host remains limited, necessitating the development of in vitro models to better …

2026-02-27 Minutes Of The Executive Committee Of The Academic Senate Senate, University Of Dayton. Academic Senate. Executive Committee

ECAS Minutes

Approved minutes of a meeting of the Executive Committee of the Academic Senate of the University of Dayton.

Reforming Medical Training For Psychiatry Of Intellectual Disability: From Margins To Mandate, Rohit Shankar

Peninsula Medical School

In its 2025 medical training review, National Health Service (NHS) England highlighted the urgent need to modernise postgraduate medical education in England to meet NHS population needs while supporting doctors’ professional aspirations. The psychiatry of intellectual disability, a subspecialty marked by declining recruitment, uneven service provision and limited research capacity, provides a critical test case for these reforms. This article applies the 11 recommendations from the review to doctors training in this subspecialty. Drawing on recent evidence, it advocates for equitable, flexible and academically grounded reforms that embed psychiatry of intellectual disability within mainstream medical education, workforce planning and national …

A National Uk-Wide Survey Of Tranexamic Acid Use In Vascular Surgery, K Atha, A Shah, J Fabes, K Bera

Peninsula Medical School

Background: Tranexamic acid (TXA) is widely used to reduce perioperative bleeding in several surgical specialties; however, its role in vascular surgery remains uncertain. Concerns regarding arterial, venous and graft thrombosis, together with limited and low-certainty evidence of efficacy, have contributed to variation in practice across the UK. According to the 2025 National Vascular Registry there were nearly 20,000 major vascular operations carried out across the four nations. The 2023 NHS Blood and Transplant audit found TXA uptake in vascular surgery to be low (26.5%) when compared with other specialties such as cardiac, orthopaedic and trauma surgery, which each had TXA …

Influence Of Weekend Social Jetlag On Glucose Tolerance Testing, Ariana Khzarjyan, Srushti Wagh, Graham Mcginnis

Kinesiology and Nutrition Sciences Student Research

Background: Circadian rhythms regulate physiological and metabolic functions across a 24-hour cycle. However, modern lifestyles often disrupt these rhythms. A common example is weekend schedule shifts, when people sleep and wake later than on weekdays, a phenomenon referred to as social jetlag (SJL).

Purpose: The purpose of this study was to; 1) determine whether chronic SJL leads to impaired glucose tolerance, and 2) determine if acute changes in glucose tolerance occur following a weekend of social jetlag (SJL).

Methods: Fifteen male C57BL/6 mice on a normal chow diet were used in this study. To model social jetlag (SJL), mice were …

Nanoscale Opportunities In Extracellular Matrix Mimicry, L. Andrew Lyon, Abbygail Caine, Elif Narbay, E. Daniel Cárdenas-Vásquez

Engineering Faculty Articles and Research

We present an overview of the composition, function, energetics, and dynamics of extracellular matrix and its relation to nanoscale structures and phenomena. These concepts are then related to the development of synthetic and biosynthetic materials that aim to mimic the extracellular matrix for regenerative medicine and tissue engineering technologies. Notable successes and advancements towards the goal of biomimicry are outlined, while remaining challenges and knowledge gaps towards that goal are highlighted. Finally, we frame the remaining challenges in the field in terms of nanoscience-related research opportunities that if solved, might prove to be transformative steps forward in the discipline.

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.

Prescription Monitoring Program Review Among Patients With Cancer Receiving Opioids At A Safety-Net Palliative Medicine Clinic, Soraira Pacheco, Linh M T Nguyen, Joseph A Arthur, Christopher M Manuel, Wei Qiao, David Hui

Faculty, Staff and Student Publications

Introduction: Prescription monitoring programs (PMPs) are commonly used to monitor non-medical opioid use (NMOU); however, the effectiveness of PMPs for identifying cancer patients with risk factors is not well known.

Methods: This study assessed the frequency and predictors of concerning PMP findings among cancer patients in a palliative care clinic and examined the ability of PMPs, clinical review, and urine drug testing to identify NMOU behaviors. This was a retrospective analysis of consecutive cancer patients seen by palliative care at a safety-net hospital over four years. Demographic, clinical, and psychosocial risk factors for NMOU were extracted from the medical record. …

Bone Marrow Endosteum Houses Hedgehog-Susceptible Dlx5-Expressing Osteoblast Precursor Cells, Keita Kondo, Yuki Matsushita, Shion Orikasa, Yuta Nakai, Aiko Kuroda, Shinsuke Ohba, Wanida Ono, Noriaki Ono

Faculty, Staff and Student Publications

The bone marrow endosteum provides a robust source of bone-making osteoblasts by housing various types of osteoblast precursor cells, including endosteal stem cells expressing fibroblast growth factor receptor 3 (Fgfr3) and their downstream progenitor cell populations. In fetal bone development, Dlx5 marks early perichondrial cells that populate the diaphyseal bone and marrow stroma in the postnatal stages. However, the location of Dlx5-expressing cells in the postnatal bone marrow and how they contribute to osteogenesis remain undefined. Here, we show that Dlx5

Phase I Trial Of Binimetinib Plus Hydroxychloroquine In Patients With Previously Treated Metastatic Pancreatic Cancer, S Daniel Haldar, Fen Saj, So Jung Hong, Rishi Surana, Lianchun Xiao, J Jack Lee, Brandon Smaglo, Dan Zhao, Huili Zhu, Ryan Huey, Jason Willis, M Pia Morelli, Michael Overman, Florencia Mcallister, Robert Wolff, Anirban Maitra, David Fogelman, Channing Der, Shubham Pant

Faculty, Staff and Student Publications

Background: Dual mitogen-activated protein kinase (MAPK) pathway and autophagy inhibition shows synergistic antitumor activity in preclinical models of RAS-mutant cancers. We hypothesized that autophagy blockade with hydroxychloroquine (HCQ) could overcome resistance to MEK inhibition with binimetinib (BINI) and provide clinical benefit in previously treated, KRAS-mutated, metastatic pancreatic ductal adenocarcinoma (PDAC).

Methods: This investigator-led, single-arm, open-label, phase I dose escalation/expansion trial evaluated the safety and tolerability of BINI + HCQ in patients with previously treated, metastatic PDAC (NCT04132505). Key eligibility criteria: ECOG 0-1, adequate organ function, ≥ 1 prior line of therapy for metastatic disease, and presence of KRAS …

Endosteal Stem Cells At The Bone-Blood Interface: A Double-Edged Sword For Rapid Bone Formation: Bone Marrow Endosteal Stem Cells Provide A Robust Source Of Bone-Making Osteoblasts Both In Normal And Abnormal Bone Formation, Keita Kondo, Yuki Matsushita, Shion Orikasa, Yuta Nakai, Aiko Kuroda, Shinsuke Ohba, Wanida Ono, Noriaki Ono

Faculty, Staff and Student Publications

Endosteal stem cells are a subclass of bone marrow skeletal stem cell populations that are particularly important for rapid bone formation occurring in growth and regeneration. These stem cells are strategically located near the bone surface in a specialized microenvironment of the endosteal niche. These stem cells are abundant in young stages but eventually depleted and replaced by other stem cell types residing in a non-endosteal perisinusoidal niche. Single-cell molecular profiling and in vivo cell lineage analyses play key roles in discovering endosteal stem cells. Importantly, endosteal stem cells can transform into bone tumor-making cells when deleterious mutations occur in …

Rewiring The Senses: Neural And Perceptual Adaptation Through Cultural Immersion In Chile, Alexa Castillo

University Honors Theses

This thesis explores how cultural immersion reshapes perception over time. Rather than focusing only on language acquisition, the project examines how sustained exposure to a new cultural and linguistic environment alters sensory processing, cognitive effort, and emotional experience. The study draws on cultural neuroscience and neuroplasticity research to frame immersion as a process of adaptive recalibration.

Over four weeks in Valparaíso, Chile, I documented daily changes in auditory processing, visual attention, emotional response, and social interpretation. Journal entries were analyzed using qualitative thematic coding and organized into five categories: language overload, cognitive effort, automaticity, anxiety/frustration, and belonging/comfort. Weekly intensity ratings …

Toward A Model Of Agentic Professional Learning: A Phenomenological Study Of Collective Efficacy Development, Stephanie Thomas

Education Dissertations

Collective teacher efficacy (CTE) refers to a faculty’s shared belief in its collective ability to take action and positively impact student outcomes in ways more influential than other predictive factors, including socioeconomic status or prior achievement. Research has shown that high levels of CTE are associated with improved student achievement as well as positive outcomes and productive behaviors among educators. However, limited attention has been given to how intentional design and facilitation of professional learning experiences could foster the development of CTE. Given the strong empirical evidence linking CTE with student achievement and the virtuous cycle, or bidirectional causality, between …

Small Enough To Fail: The 2018 Amendments To The Dodd-Frank Act, Regulatory Stress Tests, And Post-Pandemic Bank Failures, Jacob R. Bourgault, Edward Adams

Maryland Law Review

No abstract provided.

Roman Catholic Archbishop Of Washington V. Doe: The Constitutionality Of Retroactively Turning Back The Clock On Child Sexual Abuse Claims, Lindsey Rosenbloom

Maryland Law Review

No abstract provided.

Equity In Enhancing Family Planning Access In Rural Municipalities Of The Philippines, Jean Rachel D. Ang, Meljun R. Banogon, Teodoro Lloydon C. Bautista, Wendy D. Besa-Ang, Macario A. Felicen Ii, Jovine M. Martin, Hermie Alexander D. Sia, Jaeron Den D. Topinio

Journal of Public Affairs and Development

Fertility trends in the Philippines have decreased over the years, driven by improved implementation of family planning (FP) practices and programs. However, regional and urban-rural disparities remain evident. Based on the 2022 Philippine National Demographic and Health Survey (NDHS), the general fertility rate (GFR) in urban areas is 57 per 1,000 women aged 15–44 years, compared with 72 per 1,000 in rural areas. This study determined the factors affecting fertility rates in selected municipalities in the second to fourth-income classes, namely Candoni, Jamindan, Moalboal, Palapag, San Miguel, and Sibalom. It utilized a descriptive cross-sectional study design involving 180 women of …

Re: Conditional Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Revised Butte Hill Revegetation Specifications (Dated August 15, 2025), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.