Digital Commons Network^™

Prospective Validation Of Selective Serotonin Reuptake Inhibitor Pharmacokinetic Models For Precision Dosing In Children And Adolescents, Ethan A. Poweleit, Whitney Sparks Ms, Catherine Koertje, Addison Pritchett Ms, Gail Robertson, Lindsey Malloy-Walton, Stephani Stancil, Jeffrey R. Strawn, Alexa L. Pagano, Kathryn Kyler, Jonathan B. Wagner, Brandon Retke, Paul C. Toren, J Steven Leeder Pharmd, Phd, Laura B. Ramsey

Posters

Background: Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed to children and adolescents with anxiety and depression. However, their clinical use is complicated by marked interindividual variability in exposure, which contributes to differences in treatment response and side effects. Further, SSRIs are commonly dosed using a trial-and-error approach. Model-informed precision dosing could improve treatment outcomes, yet existing SSRI population pharmacokinetic (PK) models have not been prospectively validated and may not generalize to pediatric patients. This study aims to evaluate how accurately these models predict exposure for three SSRIs—escitalopram (ESC), sertraline (SRT), and fluoxetine (FLX)—and refine them to develop tools for …

Comparison Of Agar-Based Methodologies To Broth Disc Elution For The Detection Of Aztreonam Susceptibility In The Presence Of Ceftazidime-Avibactam, Teslin Sandstrom, Andra Banete, Alice Kanyua, Kevin Davis, Susan Poutanen

Pathology, East Africa

The combination of aztreonam and ceftazidime-avibactam is a proven treatment option for infections caused by metallo-beta-lactamase (MBL)-expressing gram-negative organisms. Restoration of aztreonam susceptibility in the presence of ceftazidime-avibactam can be determined using the Clinical and Laboratory Standards Institute (CLSI)’s broth disc elution (BDE) method; however, the high manual workload and significant material footprint of this assay make it difficult to implement in a high-throughput clinical microbiology lab. This study evaluates two agar-based methods for the detection of susceptibility to the combination of aztreonam and ceftazidime-avibactam, using BDE as the comparator methodology. Resistant Enterobacterales, Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Acinetobacter spp. …

Low-Dose Aspirin For Preventing Intrauterine Growth Restriction And Pre-Eclampsia In Sickle Cell Pregnancy, Lydia Pecker, Sophie Lanzkron

Cardeza Foundation for Hematologic Research

No abstract provided.

Optimizing And Fortifying Ai Software Through The Lens Of Artifact Synthesis, Jieke Shi

Dissertations and Theses Collection (Open Access)

Artificial Intelligence (AI) has transformed the software landscape, ushering in a new era of intelligent systems that increasingly shape our daily lives. This transformation is evident in various domains, including Software Engineering (SE), where Large Language Models (LLMs) support many development tools, and control systems, where self-driving cars and autonomous drones rely on deep learning models for real-time decision-making. These AI systems are collectively referred to as AI software, with the former categorized as AI4SE software (AI for Software Engineering) and the latter as AI4Control software (AI for Control). As AI software becomes central to modern computing infrastructure, its reliability …

Dyadic Trust Congruence And Asymmetry: The Mediating Role Of Psychological Needs On Trust And Performance, Hongyin Cai

Dissertations and Theses Collection (Open Access)

This thesis examines how trust congruence and trust asymmetry shape leader-subordinate relationships and how these dynamics influence LTS and subordinate job performance. Trust congruence and trust asymmetry are defined by the degree of alignment between STL and SFT. Drawing on Self-Determination Theory, this study investigates these processes from the subordinate’s perspective using a mixed-method design that integrates qualitative interviews and quantitative analysis.

Results show that subordinate trust in leader (STL), subordinate felt trust (SFT) and leader trust in subordinate (LTS) are three distinct constructs. Trust asymmetry is prevalent, with subordinate often trusting more than they feel trusted. Asymmetry meaningfully shapes …

Gen Z Employees’ Characteristics And Their Impacts On Work Motivation And Outcomes: A Comparative Study Of Private Firms And State-Owned Enterprises In China, Yanfang Zheng

Dissertations and Theses Collection (Open Access)

This study examines the characteristics of Generation Z (Gen Z) employees and investigates how these traits influence work motivation and job-related outcomes within the Chinese organizational context. Specifically, the research compares employees working in state-owned enterprises (SOEs) and private firms, two dominant but structurally distinct organizational forms in China. Drawing upon self-determination theory, generational cohort theory, and organizational behavior literature, the study proposes a conceptual model in which Gen Z characteristics influence job outcomes both directly and indirectly through intrinsic and extrinsic motivation, with organizational type acting as a moderating variable. A quantitative, multi-source survey design was employed. Data were …

The Impact Of Corporate Social Responsibility On Employees' Work Attitudes And Behaviors, Qian Yuan

Dissertations and Theses Collection (Open Access)

Why do some new employees voluntarily leave within a short period after joining a corporation, while others do not? Drawing on information asymmetry theory and adverse selection theory, this dissertation argues that information asymmetry and adverse selection between job seekers and firms before organizational entry, or during the job search process, are important reasons for new employees’ short-term voluntary turnover. Because corporate social responsibility (CSR) can provide people with information about a firm’s capabilities, willingness, and intentions, this dissertation proposes that firms’ CSR activities can provide job seekers with information about various aspects of the firm. In doing so, CSR …

The Impact Of Job Demands On Work And Family Outcomes Among Healthcare Workers In China: The Moderating Effect Of Gender And Professional Identity Integration (G-Pii) And Communal Orientation, Wei Zhou

Dissertations and Theses Collection (Open Access)

Long work hours, emotional strain, and stress are just a few of the high demands placed on healthcare workers in China, which have led to occupational burnout, tension between job and family, and worse health. This research investigates the relationship between job demands and burnout via the lens of the Job Demands-Resources model and social identity theory, work-family balance, subjective well-being, and career commitment among Chinese healthcare workers. We focus on the moderating roles of gender and professional identity integration (G-PII) and communal orientation. In a two-wave investigation, 317 medical professionals from different Chinese hospitals took part. Hierarchical regression studies …

How Do Monetary Incentives Affect Prosocial Behavior Among Gig Workers?—Behavioral Experiments Based On Flashex, Peng Xue

Dissertations and Theses Collection (Open Access)

The gig economy has reshaped labor markets. Motivating mobile, loosely contracted gig workers to engage in prosocial behavior is critical for platform governance. This paper uses a randomized field experiment on FlashEx in comparable Chinese cities to examine how monetary incentives affect delivery workers’ prosocial behavior and related economic outcomes.

The main findings of this study are as follows. First, monetary incentives significantly promote gig workers’ prosocial behavior, effectively increasing both the likelihood and frequency of their participation in altruistic acts. This effect is primarily driven by the “instrumental value” mechanism in the gig economy: the platform’s gold coin rewards, …

Sustainabake, Kevin Kunta Swanson Ii

Electrical Engineering

This senior project outlines the development of an oven that utilizes renewable energy to operate safely and effectively. It aims to test building an oven using mostly basic hardware students acquired during their time at Cal Poly and provide a starting point for those interested in creating a solar-powered oven. As our society continues to innovate and increasingly relies on electricity, it is important to place more emphasis on how we can make our lives sustainable to take care of our environment without introducing excessive pollutants. Food preparation is a daily activity that typically involves significant energy consumption, making this …

Does Genetic Testing Influence Outcomes: Early Experience In Melanoma Case Series, Ryan Reyes, George Skenteris, Stella Coker Watson Self Ph.D., Ms, Christine Marie-Gilligan Schammel, Steven D. Trocha

Faculty Publications

Background:

The treatment and prognosis of melanoma have historically been based on histologic stage and Breslow depth; however, due to the increase in surveillance, melanomas are being identified at an earlier stage and lower Breslow depth. Advances in genetic testing, such as Decision Dx®, mean that melanoma diagnostic decisions and prognosis can now be directed by genetics. The purpose of this project was to assess the influence of a Decision Dx® high-grade (Class 2A/B) classification on the treatment of melanoma patients at a regional medical center, particularly those not deemed high risk by conventional classification methods, including Breslow depth and …

Screening Ptsd In Clinical Populations Within East Africa: Results From The First Follow-Up Study Of Neurogap-Psychosis, Shaili Jha, Rocky Stroud, Ana Lucia Dice, Joseph Kyebuzibwa, Stella Gichuru, Fredrick Ochieng, Manasi Sharma, Hayden Mountcastle, Lydia Marshall, Lukoye Atwoli

Brain and Mind Institute

Background: Given the high burden of trauma in Sub-Saharan Africa, there is a critical need for scalable tools to screen for trauma and posttraumatic stress disorder (PTSD) symptoms, especially in low-resource settings.

Objective: This study aimed to evaluate the utility, reliability, and validity of the Primary Care PTSD Screen for DSM-5 (PC-PTSD-5) administered over the telephone to individuals previously enrolled in the Neuropsychiatric Genetics of African Populations-Psychosis study (NeuroGAP-Psychosis) study in Uganda (N = 4,921) and Kenya (N = 3,149).

Method: Cases with psychosis and controls without psychosis (patients, caretakers, or employees) were recontacted from the NeuroGAP-Psychosis …

Cultivating The Future Of Dentistry: Evolution Of Dental Education, Eric Mediavilla Dds, Fagd

Metro Denver Dental Society Articulator Magazine

This article explores how dental education and practice are rapidly changing with rising enrollment, growing female representation, and advanced digital technologies like VR simulators, 3D scanning and AI imaging. As educators balance innovation with foundational techniques, dentistry continues to evolve.

Credit Card Reform Tops Legislative Wins For Dentistry, Lance Plunkett Jd, Llm

The New York State Dental Journal

Several new laws of interest to dentistry were passed in 2025 and two of them were NYSDA’s own proposals, making the 2025 legislative session a productive one for the State Association, arguably the best in years.

Extraction Of Teeth Or Root Tips From Underneath Fixed Partial Denture Abutments Or Pontics: A Case Report, John S. Mamoun D.M.D.

The New York State Dental Journal

A dental patient may present with a fixed partial denture such that a tooth or a fractured tooth root that was once a terminal abutment or a pier abutment of the fixed partial denture may need extraction from underneath the abutment without removing the fixed partial denture. The patient may need to retain the fixed partial denture for financial or esthetic reasons, or to use the fixed partial denture as a long-term provisional restoration until the extraction site heals, or until a new fixed partial denture is fabricated.

This article presents a clinical report describing a technique for extracting a …

N Y State Dent J March 2026

The New York State Dental Journal

In the March 2026 issue, the reader will find the following feature articles:

• Pebbly Gingival Nodule in an Older Male
• Extraction of Teeth or Root Tips from Underneath Fixed Partial Denture Abutments or Pontics
• Successful Regenerative Endodontic Therapy of an Immature Dens Evaginatus Mandibular Second Premolar with Apical Periodontitis

This issue includes regular columns with regional news impacting the New York membership including editorial and perspectives columns, legal, association activities, component news, continuing education opportunities, and classifieds.

Enhancing Pediatric Tube Weaning With Remote Patient Monitoring: A Pilot Quasi-Experimental Study, Sarah T. Edwards, Dana Bakula, Kristina Nash, Saiyara Baset, Amy Ricketts, Julianne Brogren, Ryan M. Thompson, Sarah Bullard, Rachel Graham, Janelle R. Noel-Macdonnell Phd, Brenda Fetter, Lori A. Erickson

Manuscripts, Articles, Book Chapters and Other Papers

Objective: Feeding-tube weaning is conducted in both inpatient and outpatient settings, with significant logistical, financial, and structural barriers to both approaches. We sought to assess whether remote patient monitoring (RPM), using a mobile application, which would overcome many of these barriers, could be effective in helping patients tube wean. Methods: We prospectively enrolled patients with a feeding tube, aged 0–3 years. Enrolled families entered data daily into the remote application. Data were monitored by a nurse and reviewed weekly by a multidisciplinary team. A standard hunger provocation protocol was used, paired with medical, behavioral, oral motor, and nutrition interventions, as …

The Role Of Top-Down Appetite Self-Regulation In The Development Of Healthy Eating Behaviors Among Children: A Narrative Review And Socialization Framework, David J Bridgett, Sheryl O Hughes, Matthew Broussard, Daniela Mccourt, Christina M Croce, Jennifer O Fisher

Children’s Nutrition Research Center Staff Publications

Appetite self-regulation (ASR) among children is thought to have a fundamental role in shaping the development of healthy eating behaviors, dietary intake, and growth during childhood. Parallel to developmental frameworks for understanding "general" self-regulation among children, ASR has been described as involving children's use of "top-down" cognitive processes to moderate "bottom-up" biological drives around food approach and avoidance in the interest of achieving desired eating behaviors or outcomes. Whereas bottom-up ASR processes during early childhood are well characterized, particularly in the context of dysregulation and obesity risk, the role of top-down ASR processes in the development of healthy eating behaviors …

Perceptions And Use Of Behaviour Change Interventions For Physical Activity In Chronic Respiratory Disease In The Republic Of Ireland, Ciara Hanrahan, Joseph G Mcveigh, Terence M O'Connor, Thierry Troosters, Julie Broderick

Children’s Nutrition Research Center Staff Publications

Objectives: Behaviour change interventions may support physical activity behaviour in people with chronic respiratory disease. The most effective interventions for long-term physical activity behaviour change in this cohort remains unclear. This aim of this study was to explore the use and perceptions of behaviour change interventions by both providers of physical activity programmes for people with chronic respiratory disease and by people living with chronic obstructive pulmonary disease (COPD) in The Republic of Ireland.

Design: Two anonymous online and paper-copy cross-sectional surveys, piloted and mapped to the COM-B model of behaviour change, were distributed via social media and relevant gate-keepers …

Pre- And Postnatal Exposure To Pm2.5 And No2 And Blood Pressure In Children: Results From The Echo Cohort, Yu Ni, Andrew Law, Xingyu Gao, Adam A Szpiro, Christine T Loftus, Miranda Jones, Logan C Dearborn, Marnie F Hazlehurst, Allison R Sherris, Sindana Ilango, Kaja Z Lewinn, Nicole R Bush, Qi Zhao, Leonardo Trasande, Joseph T Flynn, Daniel A Enquobahrie, Ruby H N Nguyen, Tom O'Connor, Arpita K Vyas, Mingyu Zhang, Hooman Mirzakhani, Alison Hipwell, Anne Starling, Alicia K Peterson, Akhgar Ghassabian, Assiamira Ferrara, Judy Aschner, Scott Collingwood, Margaret R Karagas, Michelle Katzow, Annemarie Stroustrup, Mehtap Haktnair, Tina V Hartert, Brittney M Snyder, Sophia Jan, Anne Marie Singh, Dana Dabelea, Angela M Malek, Jennifer K Straughen, Carlos A Camargo, Miatta A Buxton, Rosalind Wright, Kecia Carroll, Keia Sanderson, Daphne Koinis Mitchell, Viren D'Sa, Christine Hockett, Anne L Dunlop, Shohreh F Farzen, Sunni L Mumford, Akram N Alshawabkeh, Hudson P Santos, Xueying Zhang, Zhongzheng Niu, Nan Ji, Carrie Breton, Donghai Liang, Catherine J Karr, Echo Cohort Consortium

Children’s Nutrition Research Center Staff Publications

Background: There is growing interest in understanding the link between early life exposures to ambient air pollution and childhood blood pressure; however, existing findings, largely from single site/cohort studies, are inconclusive.

Methods: We examined the association between exposures to fine particulate matter (PM2.5) and nitrogen dioxide (NO2) and blood pressure measured at age 5-12 years in 4863 U.S. children from 20 pregnancy cohorts of the NIH ECHO cohort. Point-based residential exposures were derived from spatiotemporal models with a biweekly resolution and averaged over each trimester, the whole pregnancy, and child age 0-2 years. We converted systolic (SBP) and diastolic blood …

The 2026 Richard G. Spolzino Access To Care Humanitarian Award Recipient - Carl H. Tegtmeier, D.M.D.

Bulletin of the Ninth District Dental Association

This article celebrates the 2026 Richard G. Spolzino Access to Care Humanitarian Award Recipient, Dr. Carl H. Tegtmeier.

Rmdc: Dig Deeper. Grow. Connect. Have Fun., Bryan Savage

Metro Denver Dental Society Articulator Magazine

The 2026 Rocky Mountain Dental Convention (RMDC) brought together approximately 6,500 dental professionals for a three-day event organized by MDDS. The convention featured top national speakers, a dynamic Expo Hall, and emerging research connecting oral and systemic health. Insights from ADA Forsyth Institute researchers highlighted advances in understanding the oral microbiome, inflammation, and environmental impacts on dental development. The RMDC continues to emphasize medical-dental integration through expanded programming and hands-on diagnostic experiences, fostering collaboration across disciplines.

Incidence Vs. Prevalence, Allen Vean Dmd

Metro Denver Dental Society Articulator Magazine

Despite advances in dental technology, dental caries remain the most common chronic disease in children and adults. This reflection highlights the ongoing challenge of early childhood caries and the critical role of parental supervision, preventive care and collaboration with medical providers.

Courageous Conversations: A Dental Professional’S Most Powerful Skill, Katherine Eitel Belt

Metro Denver Dental Society Articulator Magazine

Many professionals avoid difficult conversations out of fear of conflict or failure, but avoidance only worsens problems and erodes trust. This article by Ms. Katherine Eitel Belt offers practical tools for having courageous, productive dialogues. The author shared tips, including listening first, starting from agreement, suspending judgment and emphasizing choice. Ms. Eitel Belt makes a case that by approaching conversations with empathy, openness, and curiosity, leaders can resolve issues more effectively, strengthen relationships, and build healthier, more collaborative teams.

Pebbly Gingival Nodule In An Older Male, Victoria L. Scarpa D.D.S., M.S., Yussra O. Mahmud M.P.H., B.S., Daria Vasilyeva D.D.S., Ph.D.

The New York State Dental Journal

We herein present a case of a giant cell fibroma in an older adult male that clinically has a pebbly or bosselated surface architecture, mimicking a squamous papilloma. The giant cell fibroma is a fibrous tumor distinct from the common irritation fibroma and may easily be mistaken for a papilloma based on clinical features. This case is reported to provide diagnostic value to the general practitioner.

Successful Regenerative Endodontic Therapy Of An Immature Dens Evaginatus Mandibular Second Premolar With Apical Periodontitis Case Report, Jake Horowitz D.D.S., Prashant Sukhani D.M.D., Aaron Brandwein D.D.S., Fagd, Ficd, James Sconzo D.M.D.

The New York State Dental Journal

Background: Dens evaginatus cusps typically have pulpal tissue, and fracturing of the cusp leads to necrosis. Immature permanent teeth with pulp necrosis have traditionally been treated with apexification, which eliminates infection but does not promote root development.

Methods: Regenerative endodontics utilizes revascularization by infiltrating stem cells from the apical papilla and using them to treat an immature necrotic tooth with periapical infection.

Results: Periapical radiolucency completely resolved, root length and thickness increased, and vitality returned at the one-year follow-up.

Conclusion: Regenerative protocols promote root development, reducing fracture risk. This treatment offers improved outcomes with fewer appointments and shorter treatment duration.

There’S A Vaping And Marijuana Crisis. Dentists Can Help Stem It, Bernard Fialkoff D.D.S.

The New York State Dental Journal

Dentists are perfectly positioned to deliver important information to their patients about the dangers of toxic alternatives to tobacco smoking.

Intraocular Amyloidosis Presenting With Secondary Glaucoma: A Clinical-Pathologic Report And Literature Review, Joseph B Lin, James C Liu, Rajendra S Apte, George J Harocopos

2020-Current year OA Pubs

PURPOSE: We describe a case of intraocular amyloidosis presenting as secondary glaucoma, highlighting the clinical presentation and pathologic correlates. We also review the medical literature on all prior reported cases and discuss the diagnostic challenges pertinent to this particular case.

OBSERVATIONS: We report the case of a 72-year-old man presenting with medically intractable elevations of intraocular pressure. On clinical examination, the anterior segment was unremarkable, but there were significant vitreous opacities. The patient underwent tube shunt surgery, and a simultaneous aqueous humor biopsy was acellular and nondiagnostic. A subsequent pars plana vitrectomy demonstrated amyloid aggregates on histology. Mass spectrometric analysis …

Atypical Superotemporal Iris And Retinal Coloboma, Katina N Patterson, Margaret M Reynolds, Gregg T Lueder

2020-Current year OA Pubs

PURPOSE: To report our findings in a patient with an atypical case of supertemporal iris and retinal coloboma, and to assess its systemic associations and potential genetic causes.

OBSERVATIONS: A premature female infant born at 31 weeks gestation presented a left eye superotemporal coloboma affecting both the iris and retina. Systemic abnormalities included a left multicystic kidney, hypoplastic left kidney, atrial septal defect, ventricular septal defect, and mild pulmonary valve stenosis. Whole genome sequencing and mitochondrial deoxyribonucleic acid (DNA) sequencing were performed, and both returned negative results.

CONCLUSIONS AND IMPORTANCE: The absence of genetic findings from the negative results of …

When Detention Becomes A Death Sentence: The Urgent Need For Greater Due Process Protections For Ice Detainees, Kyle J. Smith

Vanderbilt Law Review

This Note argues that U.S. immigration detention, though legally classified as civil, operates as a punitive carceral system that routinely subjects immigrants to abuse, neglect, and preventable death. Drawing on the tragic case of Ernesto Javier Rocha Cuadra and other documented instances of physical violence, medical neglect, solitary confinement, and sexual abuse, it demonstrates how U.S. Immigration and Customs Enforcement ('ICE') relies on detention as a default mechanism rather than as a last resort. The result is a system that mirrors the criminal legal system in scale and severity but denies detainees its constitutional safeguards.
The analysis situates the rise …