Digital Commons Network^™

Myh7 C.5326a>G (P.Ser1776gly) Variant In Hypertrophic Cardiomyopathy Patients From Filipino Descent: A Case Series, Mohammed Hussein, Katherine Martinez, Patrycja Galazka, Suhail Allaqaband, A Jamil Tajik, Asad Ghafoor, Steve R. Ommen

Aurora GME

Case:

Background: Cardiac B Myosin heavy chain (MYH7) gene mutation variant c.5326A>G (p.Ser1776Gly) is found in some hypertrophic cardiomyopathy (HCM) cases. We present two Filipino ethnic HCM patients with this variant to indicate strong association between this variant and this ethnicity.

Case: 1) 57-year-old adopted man had echo for dyspnea. It showed left ventricular (LV) hypertrophy and LV ejection fraction of 38%. Coronary angiogram was normal. Cardiovascular magnetic resonance (CMR) suggested cardiac amyloidosis (CA) vs burned-out HCM. CA was ruled out by endomyocardial biopsy, hence the HCM diagnosis. He had the above variant.

2) 42-year-old woman came for workup …

Tavi For Pure Aortic Valve Insufficiency: What To Expect?, Mohammed Hussein, Qais Radaideh, Tanvir Bajwa

Aurora GME

Background: Lack of US-approved devices kept transcatheter aortic valve implantation (TAVI) for aortic insufficiency (AI) an area of unmet need. We present pure AI case managed with current TAVI devices.

Case: 90-year-old man with severe noncalcified trileaflet regurgitant aortic valve, dilated aortic root (4.1 cm), and hypokinetic left ventricle (LV), was deemed TAVI candidate and high surgical risk. SAPIEN Ultra Resilia 29mm valve +8 cc was deployed under pacing. Before femoral access site closure with pre-Perclose, we noted central AI jet on echo. Angiogram showed LV valve migration. We swiftly reinserted the 16-Fr sheath we just pulled. We deployed a …

Covenants Not To Compete Are Again Being Scrutinized By Federal Regulators, Daniel Schulte Jd

The Journal of the Michigan Dental Association

This column examines the increasing federal scrutiny of non-compete agreements by the Federal Trade Commission (FTC). It notes that both the Trump and Biden administrations have prioritized curtailing the misuse of these agreements, particularly in healthcare. The article provides practical steps for employers to audit existing agreements for reasonableness and individualization. It encourages exploring alternatives such as non-solicitation and confidentiality clauses and stresses the importance of documenting the legitimate business interests that justify any remaining non-compete requirements to withstand future regulatory scrutiny.

The Win Ratio For Evaluating Edoxaban Vs Dalteparin For Cancer-Associated Venous Thromboembolism: An Analysis Of The Randomized Hokusai Venous Thromboembolism Cancer Trial, Nick Van Es, Luuk J J Scheres, Kristen M Sanfilippo, Harry Büller, Marc Carrier, Marcello Di Nisio, Michael Grosso, Renato D Lopes, William F Mcintyre, Bjorn Redfors, Annelise Segers, Peter Verhamme, Jeffrey I Weitz, Patrick M Bossuyt, Deborah M Siegal

2020-Current year OA Pubs

BACKGROUND: The Hokusai Venous Thromboembolism (VTE) Cancer trial demonstrated that edoxaban was noninferior to dalteparin for the treatment of cancer-associated venous VTE.

OBJECTIVES: We reanalyzed the trial using the win ratio, an approach that evaluates a composite of outcomes in a hierarchical order.

METHODS: Forty-nine thrombosis experts ranked 10 outcomes in order of clinical importance from all-cause death (most important) to clinically relevant nonmajor bleeding (least important). We performed unmatched pairwise comparisons between participants on edoxaban and those on dalteparin at 6- and 12-month follow-up. Within each pair, edoxaban was assigned a win, loss, or tie according to the hierarchy …

Longitudinal Analysis Of Rotator Cuff Repair: Joint Kinematics And Clinical Outcomes, Sujata Khandare, Rebekah L Lawrence, Alena Jalics, Roger Zauel, Vasilios Moutzouros, Eric C Makhni, Stephanie Muh, Michael J Bey

2020-Current year OA Pubs

BACKGROUND: Rotator cuff repair is a common surgical procedure, but postoperative outcomes can be highly variable, and postoperative repair tissue healing remains a significant clinical challenge. Furthermore, the biomechanical effects of rotator cuff repair are not fully understood.

METHODS: Twenty-two participants scheduled for arthroscopic rotator cuff repair were evaluated preoperatively and at 3, 12, and 24 months postsurgery. The following data were recorded at each time point: glenohumeral and scapulothoracic kinematics, shoulder strength, and patient-reported measures of pain and function. Postoperative repair integrity was assessed via magnetic resonance imaging at 3 months and 24 months postsurgery.

RESULTS: At 3 months …

Piezo Mechanosensitivity In Chondrocytes Is Differentially Modulated By L-Type And T-Type Voltage-Sensitive Ion Channels, Alireza Savadipour, Gabrielle K Marushack, Robert J Nims, Jaquelin M Garcia-Castorena, Wolfgang Liedtke, Farshid Guilak

2020-Current year OA Pubs

OBJECTIVE: One of the primary factors contributing to OA development is altered or excessive mechanical stress on the joint, which chondrocytes sense in part through the PIEZO mechanosensitive ion channels. These channels activate signaling pathways that result in joint inflammation and cartilage degeneration. In addition to PIEZO channels, voltage-gated calcium (Ca

DESIGN: To better understand the relationship between PIEZO1 and VGCCs, we quantified porcine chondrocytes' intracellular Ca

RESULTS: In primary chondrocytes, nifedipine, an L-type VGCC blocker, reduced PIEZO1 sensitivity to both mechanical compression and pharmacological agonism, while NNC-55, a T-type VGCC blocker, increased PIEZO1 activation in response to both stimuli. …

Aging Reduces Motivation Through Decreased Bdnf Expression In The Ventral Tegmental Area, Hanyue Cecilia Lei, Kyle E Parker, Chao-Cheng Kuo, Carla M Yuede, Jordan G Mccall, Shin-Ichiro Imai

2020-Current year OA Pubs

Age-associated reduced motivation is a hallmark of neuropsychiatric disorders in the elderly. In our rapidly aging societies, it is critical to keep motivation levels high enough to promote healthspan and lifespan. However, how motivation is reduced during aging remains unknown. Here, we used multiple mouse models to evaluate motivation and related affective states in young and old mice. We also compared the effect of social isolation, a common stressor in aged populations, to those of aging. We found that both social isolation and aging decreased motivation in mice, but that Bdnf expression in the ventral tegmental area (VTA) was selectively …

Gendered Organising: Decolonial Feminist Epistemologies From Marginalised Women Textile Traders In Southwest Nigeria, Irenitemi Gbemisola Abolade

Doctoral

For decades, discourse has been constructed for and about Nigerian women, rather than in dialogue with them, despite their rich worldview rooted in Indigenous knowledge systems. Empirical studies have consistently focused on Europe and America as sources of knowledge production, while treating the Global South as the object of knowledge. As a result, little is known about how work and organising/organisation are done, particularly in the informal economy. This study, Gendered Organising: Decolonial Feminist Epistemologies from marginalised women, introduced us to the lived experiences of women textile traders in Southwest Nigeria. It explores how these women's gendered organising practices contribute …

Detection Of Adaptive Immune Receptor Cdr3s In Tumor Proteomes And Correlations With Survival Probabilities, Arpan Sahoo, Eddie Fung, Taha Huda, Brosi Chobrutskiy, Veda Naga Priya Vangala, George Blanck

USF-LVHN SELECT

No abstract provided.

Mini-Course On Community Resources For Patients With Disabilities, Abigail Weisse, Vinita Kiluk, Kyle Lien, Nora Newcomb, Aishwarya Vuppala, Franklin Sun, Shannon Mccarthy, Anita Narkhede, Marjorie Fitzsimmons

USF-LVHN SELECT

No abstract provided.

Understanding The Current State Of Inpatient Chf Care At Lvhn Cedar Crest And Determining Potential Areas Of Improvement, Alex Wang, Shuisen Li Do

USF-LVHN SELECT

No abstract provided.

Socioeconomic Profiles And Barriers Among Committed Female Juveniles In The Florida Department Of Juvenile Justice, Aishwarya Vuppala, Kristopher Kaliebe, Sherry Jackson, Jorge Hernandez

USF-LVHN SELECT

No abstract provided.

Implementation Barriers And Change Management Considerations In Deploying A Literature-Informed, Respiratory Therapy–Driven Copd Care Bundle With Ehr-Based Readmission Risk Stratification, Yusuf Aboul-Nasr, David M. Richardson Md

USF-LVHN SELECT

No abstract provided.

Imaging-Guided Interventional Management Of Chronic Pelvic Pain:Patient Characteristics And Procedural Utilization Among Responders, Ayushi Vashishtha, Joseph E. Patruno Md

USF-LVHN SELECT

No abstract provided.

Point-Of-Care Vision Correction: A Pilot Study Of Mobile Refractive Screening And Same Day Glasses Distribution In A Street Medicine Program, Tejasvi Paturu, Veena Jajoo, Emily Coughlin, Rebecca Lipscomb, Seth A. Campbell Pa-C

USF-LVHN SELECT

No abstract provided.

A Retrospective Cohort Study Exploring Predictive Factors Of 30-Day Mortality In Intracerebral Hemorrhage Patients, Alan R Spicer, Veena Jajoo, Rahul Mhaskar, Marla Hairston, Crystal Dixon, W Scott Burgin

USF-LVHN SELECT

No abstract provided.

Timing Is Everything: A Quality Improvement Project Of Colonoscopy Withdrawal Time, Richard Barry Sirard, Amy Slenker Md, Rachel Patel Do, Shashin Shah Md

USF-LVHN SELECT

No abstract provided.

Association Between Infection With Multidrug Resistant Staphylococcus Aureus And Patient Risk Factors, Ariana Virgillio, Emily A. Felton, Josh Alvior, Abigail Eglinton, Deanna N. Becker, Amorce Lima, E Cella, T Azarian, Suzane Silbert, Lindsey N. Shaw, Kami Kim

USF-LVHN SELECT

No abstract provided.

Youth Suicide Across The Lehigh Valley Health Network Region:Determining Common Lethal Means Used Locally, Madeline Pollak, Emmanuel Annor Md, Rebecca Lipscomb, Dhanalakshmi Ramasamy Md

USF-LVHN SELECT

No abstract provided.

Assessing The Correlation Between Prior Influenza A Exposure And Survival Rate Of Patients With Squamous Cell Carcinoma Of The Lung, Schuyler Van Den Nieuwenhuizen, George Blanck

USF-LVHN SELECT

No abstract provided.

Standardizing Postoperative Pain Management In The Neonatal Intensive Care Unit: A Retrospective Quality Improvement Analysis And Protocol Development, Timothy Nehila, Laura Hayn Pharmd, Amy L. Serfas Bsn, Rn, Roseanna Hanson Bsn, Msn, Breeann Jensen Msn, Crna, Abhaya Seshachar Md, Wendy J. Kowalski Md, Oluwatobi Adegboyega Md, Marybeth Browne Md

USF-LVHN SELECT

No abstract provided.

Sexually Transmitted Infections At A Health Clinic Serving Older Adolescents And Young Adults: An Analysis Of Demographics, Health Care Access, And Positivity Rates, Shaliz Aflatooni, Margaret Van Cleve, Anna Sizemore, Sarah A Commaroto, Emily Coughlin, Rahul Mhaskar, Carina A. Rodriguez, Lisa J. Sanders

USF-LVHN SELECT

No abstract provided.

Baseline Assessment Of Advance Care Planning Documentation Among High-Risk Ed Patients, Sierra Barber, Marna R. Greenberg Do, Mph, Facep

USF-LVHN SELECT

No abstract provided.

A Comparative Operational Analysis Of Patient Access And Clinician Productivity: Identifying Success Drivers In Pediatric Gastroenterology, Lionel Sam, Liborio Larussa Md

USF-LVHN SELECT

No abstract provided.

Subdural Hematomas At A Cancer Center: Large Retrospective Review Of Survival And Prognostic Indicators, Samuel Bauserman, Trevor Pharr, Samantha Schimmel, Bassel El Sayed, Alexander Becker, Andre Beer-Furlan

USF-LVHN SELECT

No abstract provided.

Characterization Of Transgender Men Undergoing Hysterectomy At The Lehigh Valley Health Network, Christine Peng, Shae Duka Mph, Patricia L. Mara Md

USF-LVHN SELECT

No abstract provided.

Assessing Evidence-Based Care In Hospitalized Lyme Disease: A Quality Improvement Study, Quentin Boose, Raul E Davaro Md

USF-LVHN SELECT

No abstract provided.

Trends In Alcohol Withdrawal With Relation To Race/Ethnicity, Angela Nguyen, Alexandra Amaducci Do

USF-LVHN SELECT

No abstract provided.

Selective Icu Admission Following Head And Neck Free Flap Reconstruction: A Retrospective Study, Jacob Parker, Emma Dunn, Alisa Vidwans, Mayte Diaz, William Nick Doyle Bs, Samer Elsamna, Tara Mohktari, Christopher Nickel, Matthew Mifsud

USF-LVHN SELECT

No abstract provided.

Perspectives Of African American Mothers On Breastfeeding Support During Newborn Hospitalization: Addressing Disparities In Breastfeeding Exclusivity, Melissa Chow, Sarah A Commaroto, Kaen Fugate, Karyn Gerstle

USF-LVHN SELECT

No abstract provided.