Digital Commons Network^™

Outcomes Associated With A Pediatric Intensive Care Unit Sedation Weaning Protocol, Kimberley Harper, Jessica Anderson, Julie S. Pingel, Katharine Boyle, Li Wang, Christopher J. Lindsell, Ann Sweeney, Kristina A. Betters

Journal of Pediatric Intensive Care

Objective: To compare patient outcomes before and after implementation of a risk stratified pediatric sedation weaning protocol. Methods: This observational cohort study, in a 30-bed tertiary care pediatric intensive care unit (PICU), included patients requiring opioid, benzodiazepine and/or dexmedetomidine infusions. Outcomes (duration of wean, PICU length of stay (LOS), and withdrawal assessment tool (WAT-1) scores) were collected by retrospective chart review for 12-months before and after protocol implementation. The influence of the protocol was assessed using an interrupted time series analysis (ITS). Results: There were 49 patients before and 47 patients after protocol implementation. Median opioid wean duration pre-protocol was …

Neutrophil Lymphocyte Ratio And Platelet Lymphocyte Ratio As Predictors Of Disease Severity And Mortality In Critically Ill Children: A Retrospective Cohort Study, Sangeetha Shenoy, Shruti Patil

Journal of Pediatric Intensive Care

Objectives: The aim of this study was to determine the ability of Neutrophil lymphocyte ratio and Platelet lymphocyte ratio to predict severity of illness as assessed by 2 scoring systems, namely, Pediatric Logistic Organ Dysfunction-2(PELOD-2) and Pediatric Risk of Mortality-III(PRISM-III) and outcome. Methods: This was a retrospective cohort study wherein all critically ill children aged 1month to 18years admitted in pediatric intensive care unit from January 2021 to October 2022 were included. Children with chronic systemic diseases and with hematological illness were excluded from the study. Demographic details, diagnosis, PRISM-III-24 and PELOD-2 scores at admission and outcome were retrieved from …

Fluid Removal In Children On Continuous Renal Replacement Therapy Improves Organ Dysfunction Score, Sachin D. Tadphale, Peter M. Luckett, Raymond P. Quigley, Archana V. Dhar, Diane K. Gollhofer, Vinai Modem

Journal of Pediatric Intensive Care

Objectives: To assess impact of fluid removal on improvement in organ function in children who received continuous renal replacement therapy (CRRT) for management of acute kidney injury (AKI) and/or fluid overload (FO). Methods: A retrospective review of eligible patients admitted to a tertiary level intensive care unit over a 3-year period was performed. Improvement in non-renal organ function, the primary outcome, was defined as decrease in non-renal component of Pediatric Logistic Organ Dysfunction (PELOD) score on day 3 of CRRT. The cohort was categorized into Group 1 (improvement) and Group 2 (no improvement or worsening) in non-renal PELOD score. Multivariable …

Descriptive And Clinical Characteristics Of Non-Survivors In A Tertiary Pediatric Intensive Care Unit In Turkey: 6 Years Of Experience, Zeynep Karakaya, Merve Boyraz, Seyma Koksal Atis, Servet Yuce, Muhterem Duyu

Journal of Pediatric Intensive Care

Objectives: To identify the characteristics of non-survivors in a pediatric intensive care unit (PICU) in Turkey. Methods: This is a retrospective analysis of patients who died in a tertiary PICU over a 6-year period from 2016 to 2021. Data were drawn from electronic medical records and resuscitation notes. Mode of death was categorized as failed cardiopulmonary resuscitation (F-CPR) or brain death (BD). Results: Among the 161 deaths, 136 non-survivors were included and 30.1% were younger than 1 year old. Severe pneumonia, respiratory failure and ARDS (31.6%) were the most common primary diagnoses. The most common mode of death was F-CPR …

Slow And Steady: Optimizing Icu Treatment Weans For Children With Chronic Critical Illness, Rachel L. Troch, Alexandra M. Lazzara, Flora N. Yazigi, Carly E. Blatt, Avery W. Zierk, Bethany S. Chalk, Laura M. Prichett, Sofia I. Perazzo, Khodayar Rais-Bahrami, Renee D. Boss

Journal of Pediatric Intensive Care

Objectives: Pediatric chronic critical illness (PCCI) is characterized by prolonged and recurrent hospitalizations, multiorgan conditions, and use of medical technology. Our prior work explored the mismatch between intensive care unit (ICU) acute care models and the chronic needs of patients with PCCI. The objective of this study was to examine whether the number and frequency of treatment weans in ICU care were associated with clinical setbacks and/or length of stay for patients with PCCI. Methods: A retrospective chart review of the electronic medical record for 300 pediatric patients with PCCI was performed at the neonatal ICU (NICU), pediatric ICU (PICU), …

Recent Trends In Incidence And Outcomes For Acute Myocarditis In Children In The United States, Kalpana Singh, Riad Lutfi, John J. Parent, Colin Rogerson, Mouhammad Yabrodi

Journal of Pediatric Intensive Care

Objectives: Lack of defined diagnostic criteria for acute myocarditis makes its diagnosis dependent on clinical suspicion. The objective of this study was to the current trends in demographics, clinical manifestations, treatments, and outcomes in the United States for children hospitalized with acute myocarditis. Methods: This retrospective study was conducted using data collected from the Pediatric Health Information System (PHIS) database for the years 2014-2020. We included patients 21 years or younger with acute myocarditis. The statistical analysis was performed using Chi-squared and continuous variables using Mann-Whitney U-test for continuous data comparisons. Results: We found 1199 patients with acute myocarditis. About …

The Caldwell-Gemini Bio-Harmonic Habitat: A Production-Locked, Multi-Modal Wellness System, Michael Victor Caldwell Mr.

Defensive Publications Series

Abstract The Caldwell-Gemini Bio-Harmonic Habitat v1.4 is a production-locked, TRL 7 multi-modal wellness environment designed to reduce oxidative stress biomarkers and improve tissue homeostasis. Operating under a CERN-OHL-P v2.0 license, this system integrates three independent modules: a Sleep Module (LIPUS 1.04MHz, Acoustic Gel-Pads, NTC-grid thermal management for HRV +15%), a Transit Module (Bipolar NAI aerosol precipitation for PM2.5 -70% in 60s, Ozone <0.05ppm), and an Environmental Module (Arachne PBM panels for Cortisol +12%). All modules adhere to ISO 60601-1 medical-grade safety standards. The system features Zero-Trust security with AES-256 encryption, HIPAA/GDPR compliance, local AI processing via the #22 AI Monitor, and user-owned "Resonant Keys" for biometric data. User experience is enhanced through 3D-Spacer Fabric comfort and a "Zen Mode" mobile app. The $2,950 prototype BOM is optimized for 2026 industrial supply chains, with a projected retail cost of $1,250 at scale. This v1.4 spec resolves all prior critiques, establishing a clear regulatory path as a General Wellness Device

Gci-132-N Gen-1.2: Omni-Restoration Platform For Non-Invasive Ocular Neuroprotection And Disease Monitoring, Michael Victor Caldwell Mr.

Defensive Publications Series

Abstract: GCI-132-N is a non-invasive, wearable ultrasound platform designed for superior ocular neuroprotection and disease monitoring, primarily targeting glaucoma but with applicability to early Parkinson's and Alzheimer's biomarker tracking. This GEN-1.2 dossier presents an industrial blueprint leveraging sonoporation physics, commercial-off-the-shelf (COTS) hardware, and a proprietary Caldwell-Carrier Neuro-Gel with microbubbles. Key features include a 64-element CMUT array for dual-frequency vortex sonoporation, a graphene thermal spreader, PDMS microfluidics for gel refresh, and a self-powered hybrid energy system. A "Caldwell Resonance Signature" customizes ultrasound delivery to individual ocular impedance profiles, enhancing efficiency by 30%. Real-time safety is ensured via triple-redundant interlocks, including pressure, …

Gci Omni-Vortex Integrator (V1.0): Universal Nexus Framework For The Gci Ecosystem, Michael Victor Caldwell Mr.

Defensive Publications Series

abstract: The GCI Omni-Vortex Integrator (v1.0) defines the essential framework for deploying and operating GCI's open-hardware inventions as a cohesive, functional ecosystem. This master disclosure serves as the Universal Operating System and Assembly Manual, detailing critical inter-invention dependencies, standardized interfaces (e.g., MIS 6-Pin), and an integrated deployment methodology. It ensures safe, efficient, and robust real-world operation by outlining how individual GCI components—such as the Vortex Microbubble Refiner ("Titan"), Omni-Vortex Kinetic Stack, Arachne Smart-Skin, and APR AI—must interface and collaborate. This framework prevents partial or incorrect deployments that could lead to performance degradation or system failure, thereby protecting the integrity and …

Gci Vortex Microbubble Refiner (V2.5 "Titan"): Plasma-Acoustic Hybrid For Adaptive Pfas Mineralization, Michael Victor Caldwell Mr.

Defensive Publications Series

Abstract: The GCI Vortex Microbubble Refiner (VMR) v2.5 "Titan" is an advanced open-hardware solution for the complete mineralization of per- and polyfluoroalkyl substances (PFAS) and microplastics. It leverages a novel Plasma-Acoustic Hybridization within a Geometry-Induced Cavitation manifold, augmented by MOF-functionalized "Arachne" smart-skin for real-time chemical detection and adaptive process control. Unlike conventional filtration (which merely relocates PFAS) or energy-intensive destruction methods, the VMR v2.5 integrates hydrodynamic kinetic energy harvesting with high-efficiency plasma discharge (70% Ar / 30% O2 mix) at the point of bubble collapse. The system incorporates an APR AI for closed-loop control of pulsed flow, plasma intensity, and …

Modular Auxiliary Framework For Expanding Smart Wearable Device Capabilities, Junaid Syed, Ajmal Godil

Defensive Publications Series

Smartwatches and other smart wearable devices are inherently limited by compact form factors, which often constrain battery capacity, heat dissipation, and the integration of specialized hardware. As a result, useful sensors (e.g., high-resolution cameras, advanced health monitors) are frequently omitted due to restricted internal real estate. This disclosure describes a modular auxiliary framework designed to expand wearable device capabilities. A side-mounted adapter unit is secured to the watch body to interface with existing charging and data pins. This adapter provides a standardized external connector for various hot-swappable auxiliary modules, including external batteries, sensor arrays, and/or communication hardware. Secure attachment is …

Internal Family Systems Therapy For Trauma Recovery And Addiction In Sexual And Gender Minorities, Walter Saunders

Walden Dissertations and Doctoral Studies

Sexual and gender minorities (SGM) experience disproportionately high rates of substance use disorders linked to trauma exposure, minority stress, and barriers to affirming behavioral health care. Although trauma-informed approaches have expanded, little is known about how SGM individuals experience and make meaning of their engagement in internal family systems (IFS) therapy for trauma and addiction. Guided by Schwartz’s theory of the multiplicity of the mind and minority stress theory, the purpose of this qualitative phenomenological study was to explore how SGM individuals describe and interpret their engagement in IFS therapy within the context of trauma and addiction. Interpretative phenomenological analysis …

Retirement Rankings In The Mountain West, 2025, Isabelle G. Graham, Mia Tschan, Anthony Arroyo, Kristian Thymianos, Caitlin J. Saladino, William E. Brown Jr.

Demography

This fact sheet reports 2025 data on retirement rankings in the five Mountain West states of Arizona, Colorado, Nevada, New Mexico, and Utah. The Bankrate report, “America’s best states to retire in 2025: New Hampshire takes the top spot,” presents data on retirement rankings for all 50 U.S. states. This fact sheet focuses on the overall retirement rank and individual retirement category rankings for each Mountain West state.

Child Protection Workers’ Perceptions Of Burnout And Work Dissatisfaction, Ashley-Camille Jackson

Walden Dissertations and Doctoral Studies

Child protection workers work in a stressful and demanding occupation, subject to high staff turnover and inexperienced staff. This situation has created problems for child protection workers in doing their jobs effectively—for example, handling their daily tasks and caseload—leading to potential burnout and work dissatisfaction. Existing literature has explained how burnout begins to develop as a response to chronic exposure to job-related stressors, to a point of emotional exhaustion and reduced personal accomplishment. Researchers have found that work-related conditions have contributed to the development of burnout, especially when attempting to define how one could be overworked and how much labor …

Quality Of Robotic Segmentectomy Vs. Video-Assisted Thoracoscopic Segmentectomy In Non-Small Cell Lung Cancer: A Retrospective Cohort Study, Sneha S. Alaparthi, Anurag Ishwar, Isheeta Madeka, Annie Ho, Tyler Grenda, Nathaniel R. Evans Iii, Olugbenga T. Okusanya

Jefferson Hospital Staff Papers and Presentations

Background & Methods

• Lung cancer remains a leading cause of cancer death worldwide. Sub lobar resection (segmentectomy) has proved to be a safe and effective alternative to lobectomy in recent literature.
• Our objective is to compare quality of resection between robotic assisted (RVATS) and video assisted (VATS) thoracoscopic segmentectomy. Our hypothesis is that robotic segmentectomy will allow for an improved oncologic resection.
• Retrospective cohort study of National Cancer Database (NCDB). Patients >18 undergoing RVATS or VATS segmentectomy for clinical N0M0, ≤ 2 cm between 2010-2020.
• Quality of oncologic resection assessed with presence and number of nodes examined, margin positivity, upstaging, …

Spectator 2026-03-12, Editors Of The Spectator

The Spectator

No abstract provided.

Conference Proceedings Of The 2025 Lec Teaching And Learning Conference, Martha Snyder

LEC Conference Proceedings

No abstract provided.

Pulpal Chamber Floor Thickness Of First Molars In A Black South African Sample, Marisca Meyer, Casper Jonker, Sandeepa Singh, Federico Foschi, Anna Catherina Oettlé

Peninsula Dental School

Background/Objectives: Root canal procedures on multi-rooted teeth, including first molars, depend on experience, tactile perception, and anatomical knowledge to avoid perforation in the furcation region. Studies using various methodologies and populations have reported discrepant findings on pulpal floor thickness. No study using micro-computed tomography (Micro-CT), the gold standard, has been conducted on a Black South African sample to evaluate pulpal floor thickness. Methods: In this cross-sectional, descriptive,quantitative study, Micro-CT scans of 91 maxillary and 77 mandibular first molars were reconstructed in 3D and oriented according to a reference plane along the cemento-enamel junction using Avizo software. Measurements were taken from …

Physical Changes Of Biomacromolecules Upon Covalent Surface Immobilization, Bianca Mercado Velez, Vaishali Sharma, Seth Kriz, Erico Freitas, Paul Goetsch, Caryn Heldt

Michigan Tech Publications

Immobilization of large biomacromolecules is often required for analytical quantification and physicochemical characterization. However, immobilization can alter the structure and size of the particles being studied. Here, two exosomes (derived from HEK-293 and MDA-MB-231 cells) and three viral particles (Suid herpesvirus 1 (SuHV), xenotropic murine leukemia virus (XmuLV), and porcine parvovirus (PPV)) were immobilized to different covalent chemistries to understand how surface chemistry influences particle deformation during immobilization. The surface chemistries explored were: (i) NHS (N-hydroxysulfosuccinimide) and EDC (1-ethyl-3-(3-(dimethylamino)propyl) carbodiimide hydrochloride), and (ii) poly l-lysine (PLL) and glutaraldehyde (GA). Morphological changes in biomolecules following immobilization were quantified by …

2026-03-12 As Eduardo Penalver Departs For Georgetown, How Does He Leave Seattle U?, Natalie Schorr, Hadia Noor Ahmed

The Spectator Online

No abstract provided.

Social Network Determinants Of Cigarette Forgoing And Quit-Related Conversations In A 15-Day Ecological Momentary Assessment Study In Mexico And The Us, Lizeth Cruz-Jiménez, Kevin A. Carson, Jim Thrasher Ph.D., Ma, Ms, Katia Gallegos-Carrillo, Dèsirée Vidaña-Pérez, Diego F. Leal

Faculty Publications

Introduction

Methods

Roadmap: Integrating Artificial Intelligence In Structural Health Monitoring Systems, Simon Laflamme, Erik Blasch, Flippo Ubertini, Zheng Liu, John Wertz, Christine Knott, Matthew Cherry, Eric Lindgren, Fu-Kuo Chang, Amrita Kumar, Jack Poole, Keith Worden, Austin Downey, Jie Wei, Patrick F. Musgrave, Adrian S. Wong, Guiseppe Quaranta, Marco Martino Rosso, Giuseppe Carlo Marano, Yu Chen, Et. Al.

Faculty Publications

Advances in computing and machine learning (ML) methods have led to a rapid rise in artificial intelligence (AI) research and applications in many fields. AI research benefitted from advances in computation hardware, collection and distribution of large data sets, and proliferation of software techniques. AI techniques include ML for provable results, deep learning for data exploration, reinforcement learning for control, and active learning for adaptive systems. Likewise, AI algorithms can handle large amounts of data, construct unknown representations, and provide a direct link between data and classification for decision making. These unmatched capabilities have been seen as a path to …

Montana Kaimin, March 12, 2026, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

Fentanyl Use Among People Who Inject Drugs In Two Large Pacific Northwest Metropolitan Areas., Lauren Lipira, Sara N. Glick, Courtney Moreno, Lalaine Sevillano, Matthew A. Town, Timothy W. Menza

Regional Research Institute for Human Services

Background

We examined fentanyl use and outcomes among people who inject drugs (PWID) in the urban Pacific Northwest (PNW).

Methods We conducted secondary analysis of data from the 2022 National HIV Behavioral Surveillance PWID cycle from Portland, OR and Seattle, WA. We calculated proportions of any fentanyl, injection fentanyl, non-injection fentanyl, and street pill use. Next, we compared characteristics, behaviors, and outcomes by any fentanyl use. Finally, we estimated adjusted relative risk (aRR) of overdose outcomes associated with fentanyl use and injecting less associated with type of street pill use.

Results

Among 835 PWID, 76% reported fentanyl use, 47% injection …

Academic Village Finance Authority - Open Session Book 03/12/2026, Uc Law Sf

2026 Board of Directors Agenda and Materials

No abstract provided.

Board Of Directors Quarterly Meeting - Open Session Book 03/12/2026, Uc Law Sf

2026 Board of Directors Agenda and Materials

No abstract provided.

Vision 2033, Illinois Math And Science Academy

Vision 2033

In its unwavering pursuit of both excellence and equity, IMSA offers STEM-loving Illinois students from every socioeconomic background tuition-free educational offerings and opportunities they can’t find elsewhere in the state. Its world-class cadre of faculty and administrators and extensive range of STEM classes and research experiences transcend disciplinary boundaries.

The IMSA experience also distinguishes itself through its unparalleled network of students, alumni, and partners dedicated to progress in STEM and united to help such trailblazing students fulfill their academic and career potential. Whether in class with an instructor, in the residence hall under the guidance of a resident counselor, or …

Energetic Heterogeneity In Retinal Ganglion Cells: Role Of Neuronal Activity And Implications For Resilience, Zelun Wang

Arts & Sciences Graduate Student Theses and Dissertations

Retinal ganglion cells (RGCs) form the only connection between the eye and the brain via their axons in the optic nerve. In diseases such as glaucoma, RGCs undergo irreversible neurodegeneration leading to vision loss. RGCs consist of multiple types differing in morphology, gene expression, and signaling properties. Moreover, these types exhibit differential survival after axon injury. What cellular properties vary between RGC types that could underlie their heterogeneous response to neurodegeneration? Given that energy metabolism is tightly optimized for the homeostatic and active functions of different neurons, physiologically distinct RGC types likely exhibit divergent energetic characteristics. Furthermore, energy metabolism is …

Associational Inference With Many Potential Covariates: Bayesian Information Criterion Elastic Net, Farideh Bagherzadeh Khiabani, I-Chan Huang, Jose Miguel Martinez Martinez, Shizue Izumi, Sedigheh Mirzaei, Tiange Zheng, Irina Dinu, Yutaka Yasui

COBRA Preprint Series

Background: An emerging feature in modern biomedical research is collecting and analyzing numerous variables. In the presence of many potential covariates, inference becomes challenging requiring both distinguishing a set of covariates truly associated with an outcome and estimating their corresponding regression coefficients consistently. Traditional statistical inference typically focuses on estimating coefficients assuming a pre-specified set of covariates. Further, advanced machine/statistical learning methods performing both selection and estimation predominantly focus on outcome prediction rather than association inference.

Methods: Motivated by our epidemiological research on long-term childhood cancer survivors, where we aimed to investigate associations between a large pool of longitudinal symptom …

Reared In Disaster: The Long-Run Harm From Childhood Storm Exposure, Lucas Kaplan

Center for Policy Research

I estimate how exposure to natural disasters in childhood shapes earnings and schooling later in life, using newly assembled county-date disaster records dating back to 1951 linked to residential histories in the NLSY79. I compare adult outcomes for children who are born in the same county but due to disaster timing experience different amounts of exposure, finding that severe and repeat disasters reduce earnings. I show that school-age disaster exposure drives long-run harm: exposure between ages 5 and 10 reduces educational attainment, while exposure between ages 10 and 15 reduces adult earnings. Finally, Black individuals suffer larger earnings losses than …