Digital Commons Network^™

Physical Changes Of Biomacromolecules Upon Covalent Surface Immobilization, Bianca Mercado Velez, Vaishali Sharma, Seth Kriz, Erico Freitas, Paul Goetsch, Caryn Heldt

Michigan Tech Publications

Immobilization of large biomacromolecules is often required for analytical quantification and physicochemical characterization. However, immobilization can alter the structure and size of the particles being studied. Here, two exosomes (derived from HEK-293 and MDA-MB-231 cells) and three viral particles (Suid herpesvirus 1 (SuHV), xenotropic murine leukemia virus (XmuLV), and porcine parvovirus (PPV)) were immobilized to different covalent chemistries to understand how surface chemistry influences particle deformation during immobilization. The surface chemistries explored were: (i) NHS (N-hydroxysulfosuccinimide) and EDC (1-ethyl-3-(3-(dimethylamino)propyl) carbodiimide hydrochloride), and (ii) poly l-lysine (PLL) and glutaraldehyde (GA). Morphological changes in biomolecules following immobilization were quantified by …

2026-03-12 As Eduardo Penalver Departs For Georgetown, How Does He Leave Seattle U?, Natalie Schorr, Hadia Noor Ahmed

The Spectator Online

No abstract provided.

Social Network Determinants Of Cigarette Forgoing And Quit-Related Conversations In A 15-Day Ecological Momentary Assessment Study In Mexico And The Us, Lizeth Cruz-Jiménez, Kevin A. Carson, Jim Thrasher Ph.D., Ma, Ms, Katia Gallegos-Carrillo, Dèsirée Vidaña-Pérez, Diego F. Leal

Faculty Publications

Introduction

Methods

Roadmap: Integrating Artificial Intelligence In Structural Health Monitoring Systems, Simon Laflamme, Erik Blasch, Flippo Ubertini, Zheng Liu, John Wertz, Christine Knott, Matthew Cherry, Eric Lindgren, Fu-Kuo Chang, Amrita Kumar, Jack Poole, Keith Worden, Austin Downey, Jie Wei, Patrick F. Musgrave, Adrian S. Wong, Guiseppe Quaranta, Marco Martino Rosso, Giuseppe Carlo Marano, Yu Chen, Et. Al.

Faculty Publications

Advances in computing and machine learning (ML) methods have led to a rapid rise in artificial intelligence (AI) research and applications in many fields. AI research benefitted from advances in computation hardware, collection and distribution of large data sets, and proliferation of software techniques. AI techniques include ML for provable results, deep learning for data exploration, reinforcement learning for control, and active learning for adaptive systems. Likewise, AI algorithms can handle large amounts of data, construct unknown representations, and provide a direct link between data and classification for decision making. These unmatched capabilities have been seen as a path to …

Montana Kaimin, March 12, 2026, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

Fentanyl Use Among People Who Inject Drugs In Two Large Pacific Northwest Metropolitan Areas., Lauren Lipira, Sara N. Glick, Courtney Moreno, Lalaine Sevillano, Matthew A. Town, Timothy W. Menza

Regional Research Institute for Human Services

Background

We examined fentanyl use and outcomes among people who inject drugs (PWID) in the urban Pacific Northwest (PNW).

Methods We conducted secondary analysis of data from the 2022 National HIV Behavioral Surveillance PWID cycle from Portland, OR and Seattle, WA. We calculated proportions of any fentanyl, injection fentanyl, non-injection fentanyl, and street pill use. Next, we compared characteristics, behaviors, and outcomes by any fentanyl use. Finally, we estimated adjusted relative risk (aRR) of overdose outcomes associated with fentanyl use and injecting less associated with type of street pill use.

Results

Among 835 PWID, 76% reported fentanyl use, 47% injection …

Academic Village Finance Authority - Open Session Book 03/12/2026, Uc Law Sf

2026 Board of Directors Agenda and Materials

No abstract provided.

Board Of Directors Quarterly Meeting - Open Session Book 03/12/2026, Uc Law Sf

2026 Board of Directors Agenda and Materials

No abstract provided.

Vision 2033, Illinois Math And Science Academy

Vision 2033

In its unwavering pursuit of both excellence and equity, IMSA offers STEM-loving Illinois students from every socioeconomic background tuition-free educational offerings and opportunities they can’t find elsewhere in the state. Its world-class cadre of faculty and administrators and extensive range of STEM classes and research experiences transcend disciplinary boundaries.

The IMSA experience also distinguishes itself through its unparalleled network of students, alumni, and partners dedicated to progress in STEM and united to help such trailblazing students fulfill their academic and career potential. Whether in class with an instructor, in the residence hall under the guidance of a resident counselor, or …

Energetic Heterogeneity In Retinal Ganglion Cells: Role Of Neuronal Activity And Implications For Resilience, Zelun Wang

Arts & Sciences Graduate Student Theses and Dissertations

Retinal ganglion cells (RGCs) form the only connection between the eye and the brain via their axons in the optic nerve. In diseases such as glaucoma, RGCs undergo irreversible neurodegeneration leading to vision loss. RGCs consist of multiple types differing in morphology, gene expression, and signaling properties. Moreover, these types exhibit differential survival after axon injury. What cellular properties vary between RGC types that could underlie their heterogeneous response to neurodegeneration? Given that energy metabolism is tightly optimized for the homeostatic and active functions of different neurons, physiologically distinct RGC types likely exhibit divergent energetic characteristics. Furthermore, energy metabolism is …

Associational Inference With Many Potential Covariates: Bayesian Information Criterion Elastic Net, Farideh Bagherzadeh Khiabani, I-Chan Huang, Jose Miguel Martinez Martinez, Shizue Izumi, Sedigheh Mirzaei, Tiange Zheng, Irina Dinu, Yutaka Yasui

COBRA Preprint Series

Background: An emerging feature in modern biomedical research is collecting and analyzing numerous variables. In the presence of many potential covariates, inference becomes challenging requiring both distinguishing a set of covariates truly associated with an outcome and estimating their corresponding regression coefficients consistently. Traditional statistical inference typically focuses on estimating coefficients assuming a pre-specified set of covariates. Further, advanced machine/statistical learning methods performing both selection and estimation predominantly focus on outcome prediction rather than association inference.

Methods: Motivated by our epidemiological research on long-term childhood cancer survivors, where we aimed to investigate associations between a large pool of longitudinal symptom …

Reared In Disaster: The Long-Run Harm From Childhood Storm Exposure, Lucas Kaplan

Center for Policy Research

I estimate how exposure to natural disasters in childhood shapes earnings and schooling later in life, using newly assembled county-date disaster records dating back to 1951 linked to residential histories in the NLSY79. I compare adult outcomes for children who are born in the same county but due to disaster timing experience different amounts of exposure, finding that severe and repeat disasters reduce earnings. I show that school-age disaster exposure drives long-run harm: exposure between ages 5 and 10 reduces educational attainment, while exposure between ages 10 and 15 reduces adult earnings. Finally, Black individuals suffer larger earnings losses than …

March 2026 Graduate Council Minutes, University Of Nebraska At Kearney Graduate Council

Graduate Council Minutes

No abstract provided.

Searching Like A Nurse: Finding The Best Possible Information (Undergraduate), Emily Roberts

HSLIC Faculty and Staff Instructional Resources

No abstract provided.

Geo 170 - Earth Science And Society, Yuri Gorohkovich

Open Educational Resources

Syllabus for our new OER course

The Grizzly, March 12, 2026, Renee Washart, Alex Zelaya, Nico Yanzaguano, Claudia Tracy, Andrew Mihniak, Sophia Kumar, Hadley Whitman, Erin Ewing

Ursinus College Grizzly Newspaper, 1978 to Present

We Didn't Start the Fire (in New Hall) • Disability Day of Mourning at Ursinus College • Alumni Graduate Student Panel: Health Sciences • All-Recovery: What Does it Mean to Get Sober in College? • New Spades Club Shares, Teaches, and Tournaments! • Snow Days: Are They Only Fun for Students? • Bears Basketball Finishes Up Successful Season • Women's Lacrosse Winning Big to Start the Season

University Of New Hampshire Announces Guaranteed Admissions Agreement With Mgh Institute Of Health Professions, Robbin Ray

Media Relations

No abstract provided.

The Lead, Mid-Spring 2026, Lindenwood University

The Lead

• Primary Figures: Daniel Kirk, Ph.D. (Dean); Allison Higgins (Student Senator); Dr. Michelle Whitacre; Melissa Brown (Doctoral Student); Bryson Reid (EdD Student); Emily Monti (EdD Student); Dr. Lynette Dixon. 

• Key Events: A Professional Speaker Panel is scheduled for March 19, 2026; nine students attended the MOCASE state conference in Lake Ozarks from March 2–3, 2026; Dr. Michelle Whitacre presented at the ATE Annual Meeting in Arlington, Virginia; Emily Monti is set to present at the HLC Conference in March 2026. 

• Date/Location: Mid-Spring 2026; Lindenwood University campus (specifically Roemer Hall, Harmon Hall, and Dunseth Auditorium), St. Charles, Missouri; Arlington, …

Transcription Factors Daf-16/Foxo And Hlh-30/Tfeb Form A Regulatory Axis To Control Tubular Lsysosomes Formation In C. Elegans, Cristian Ricaurte

LSU Doctoral Dissertations

The development of therapies that can be applied in human health care to promote longer and healthier lives is one of the main goals of aging research. However, many of the interventions currently available have serious adverse effects that limit their translational potential. Thus, new strategies are urgently needed to promote healthy aging in humans. Here, we reveal a functional interaction between the insulin signaling pathway and mTOR pathway that promotes healthy aging in C. elegans via lysosomal tubulation. Their respective transcription factors, DAF-16/FOXO and HLH-30/TFEB cooperate, to drive the formation of tubular lysosomes (TLs) under various contexts, which contributes …

Cost-Effectiveness And Implementation Strategies For Hypertension Management Using Non-Physician Healthcare Workers In Low- And Middle-Income Countries: A Systematic Review, Gabriel Lamkur Shedul, Olutobi Adekunle Sanuade, Emmanuel Iroboudu Okpetu, Molly Beestrum, Dike Bevis Ojji, Lisa R Hirschhorn, Mark D Huffman, Dustin D French

2020-Current year OA Pubs

BACKGROUND: This review assessed the cost-effectiveness and implementation strategies of hypertension management by non-physician healthcare workers (NPHCWs) in low- and middle-income countries (LMICs).

METHODS: A systematic search (inception-May 2024) included adults ≥18 years managed by NPHCWs LMICs, following Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Economic evaluations were assessed using Drummond's checklist and ROBINS-I.

RESULTS: Seven studies (2002-2022) conducted across eight countries enrolled 96-10,000 participants and included randomized, modeling, observational, and quasi-experimental designs. NPHCWs included pharmacists, community and village health workers, and nurses. Patients' mean age ranged 58-71 years, with 57-82% female. Outcomes assessed included cost per …

Megakaryocyte And Platelet Thrombospondin-1 Regulates Matrix Remodeling By Stabilizing Basement Membrane Col6a1 In Lung Injury, Hernán F Peñaloza, Atish Gheware, Ananya Gupta, Donovan Watza, Anupam Kumari, Zeyu Xiong, Pooja Bhojraj, Jae-Sung Kim, Bo-Ram Jin, Kyunghee Choi, Matthew R Rosengart, Jaehyung Cho, Janet S Lee, Et Al.

2020-Current year OA Pubs

An early event after lung injury is extracellular matrix (ECM) remodeling and the formation of a provisional matrix. While megakaryocytes and platelets (Mgk/plt) play important roles in hemostasis, their impact on the matrix in lung injury is not fully understood. Using lung intravital microscopy, 3D large area scanning with multiphoton confocal hybrid imaging, and label-free quantitative proteomics, the matricellular protein thrombospondin-1 (TSP1) arising from Mgk/plt protects the lung from alveolar injury. Mgk/plt cell-specific Thbs1 knockout (cKO) mice show increased alveolar barrier disruption with exaggerated neutrophil-mediated injury. The cKO mice exhibit striking extracellular matrix re-organization with reduction in basement membrane matrix …

Longitudinal Profiles Of Executive Function In Autistic And Non-Autistic Children At High Likelihood Of Autism, Tanya St John, Neva M Corrigan, Ariel Rokem, Annette M Estes, Heather C Hazlett, Juhi Pandey, Robert T Schultz, Natasha Marrus, Lonnie Zwaigenbaum, Chimei M Lee, Stephen R Dager, Joseph Piven, Ibis Network

2020-Current year OA Pubs

BACKGROUND: Executive functioning (EF) difficulties are common in autistic children and may aggregate in families. Longitudinal studies examining EF development in autistic children and their siblings are limited. In the current study, we characterized EF development from later infancy through school-age in autistic and non-autistic high likelihood (HL; with an older autistic sibling) and low likelihood (LL; without older autistic sibling) children. METHODS: Participants were 83 autistic and 235 non-autistic HL children, and 132 LL children from the Infant Brain Imaging Study. EF was assessed at ages 12 and 24 months using the A-not-B task and ages 5–14 years (school-age) …

Measuring What Matters:: Co-Creating A Human-Centred, Evidence-Informed Assessment Framework For Rehabilitation, Katie Mcbride, Zoë James, Caroline Watson

School of Law, Humanities and Social Sciences

Zoë James, Katie McBride & Caroline Watson highlight how academic expertise, practitioner knowledge, and service user experience combined has developed a rehabilitation assessment tool that is able to measure meaningful, person-centred change beyond recidivism.

Comparative Outcomes And Costs Of Robotic Assisted, Laparoscopic, And Open Partial Nephrectomy: A Contemporary Analysis Of National Inpatient Sample Data., Manisha Lin, Elizabeth Sottung, Vietbao H. Phan, Mumbi E. Kimani, Costas D. Lallas, Raegan M Davis, Scott W. Keith, Patrick Moeller, Vittorio Maio

College of Population Health Faculty Papers

PURPOSE: Partial nephrectomy is increasingly favored for small renal masses due to its renal function-preserving benefits. This study compared contemporary utilization patterns, perioperative outcomes, and hospital costs of robotic-assisted (RAPN), laparoscopic (LAPN), and open partial nephrectomy (OPN) among U.S. patients with renal cancer.

METHODS: Using the 2016–2019 National Inpatient Sample, renal cancer patients undergoing RAPN, LAPN, or OPN based on ICD-10-CM/PCS codes were identified. Patient demographics, comorbidities, hospital characteristics, length of stay (LOS), perioperative complications, and hospital costs, were summarized by surgical approach. Regression analyses adjusted for patient- and hospital-level covariates were used to compare perioperative outcomes, LOS, and costs …

Longitudinal Patterns Of Dental Health Care Utilization 18 Months Before And 36 Months After Initiation Of Index Medications For Opioid Use Disorder, Payel Jhoom Roy, Nalingna Yuan, Yaming Li, Anne Mobley Butler, Katelin B. Nickel, Gretchen Gibson, Colin C. Hubbard, Taylor L. Boyer, Katie J. Suda, Michael J. Durkin

Faculty and Staff Publications

Objectives: In 2022, the FDA issued a drug safety communication based on case studies that transmucosal buprenorphine, a medication for opioid use disorder (MOUD), may contribute to dental disease. We sought to assess longitudinal dental care utilization patterns among patients with opioid use disorder (OUD) in the 18 months before and 36 months after MOUD initiation.

Methods: Using data from the Veterans Affairs Corporate Data Warehouse (2003-2020), we created a cohort of patients coded for OUD and prescribed MOUD. Outcomes included preventive and therapeutic dental visits and oral infections within 18 months before and up to 36 months after index …

No Effect In Plasma Corticosterone Levels After Observation Of Diseased Conspecifics, B. M. Hardy, M. Chang, S. Mccallum, S. Santangelo, Patricia C. Lopes

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Organisms commonly respond to stressors in their environment by increasing the secretion of corticosterone (CORT). While increased CORT is acknowledged as a response to predation risk by organisms inhabiting a landscape of fear, new research raises the potential for changes in CORT as a response to the risk of infection by organisms in their environment. An increase in CORT of a healthy, uninfected individual in response to their perception of the risk of infection in their environment could change their susceptibility to infection, highlighting a significant role for CORT to alter host–pathogen dynamics. To investigate the effects of infection risk …

Publication Productivity Among International Medical Graduates And U.S. Medical Graduates In Neurosurgery: A Comparative Assessment Using The Arms Race Control Score, Joanna M. Roy, Omar M. M. Mansoor, Samit Sen, Aaron C. Segura, Rithvik Naga Ganti, Basel Musmar, Gilberto Perez Rodriguez Garcia, Brett Henshey, Saarang Patel, Sruthi Ranganathan, Victor Gabriel El-Hajj, Stavropoula I. Tjoumakaris, M. Reid Gooch, Robert H. Rosenwasswer, Christian Bowers, Pascal Jabbour

Department of Neurosurgery Faculty Papers

BACKGROUND AND OBJECTIVES: The Arms Race Control Score (ARCS) was developed to provide a quantitative assessment of publications among residency applicants. International medical graduates (IMGs) often have higher numbers of publications compared to U.S medical graduates (US MDs). However, there is limited knowledge of publication quality and effort among IMGs and US MDs. Our study analyzes publication productivity among IMGs and US MDs using the ARCS.

METHODS: Applicants were selected from ACGME-accredited training programs that enrolled both IMG and US MD residents over the 2018-2024 match cycle. Programs without IMG residents in a given year were excluded from the analysis. …

Database-Driven Revelations In Epilepsy: Patient Reporting Accuracy And The Circadian Timing Of Seizures, Ithay Biton

Theses and Dissertations

For over thirty years, patients have been visiting the Arkansas Epilepsy Program for diagnosis and treatment for seizures and seizure-like episodes. As part of their clinical evaluation, patients often undergo ambulatory EEG (electroencephalogram) monitoring. This routine process produces valuable data for treating the patient. In this study, over 2000 ambulatory EEG reports from 1998 to 2016 were reviewed. A large database of seizures was created from the reports, with information on 407 patients, 1611 EEG-confirmed seizures, and 1726 patient-reported seizures (IRB Protocol #17-093). The database was used to address two important issues in epilepsy. The first topic of the study …

Hardwiring Best Practice: Leveraging Teamwork And Technology For Clinical Transformation, Jenifer Ash, Cheryl Ficara, Anna-Rae Montano, Laura Bailey, Laura Dzurec

Creating Healthy Work Environments (CHWE)

In the absence of appropriate tools, efficient teamwork, and clinician skills, cardiac monitoring has no therapeutic value (New South Wales Agency for Clinical Innovation, 2022). This initially shocking notion speaks to vital aspects of cardiac monitoring—underlying clinical necessity, early recognition and intervention in response to clinical changes, and alarm mitigation to avoid alarm fatigue. As healthcare context and technology become increasingly complex, reliance on the skill of individual clinicians is inadequate and unreliable for maximizing patient safety and well-being and for achieving optimal outcomes (McLaney et al., 2022). This presentation describes how one hospital group leveraged teamwork excellence and cutting-edge …

Good Judgment In Action: Enhancing Surgeon Feedback Through Simulation, Spencer Wilhelm, Jacob Applegarth, Nathan Novotny, Ngan Nguyen

Conference Presentation Abstracts

Introduction: Effective intraoperative feedback is a cornerstone of surgical training, but remains inconsistently delivered. Surgeons who never received structured feedback during their own training lack the tools to deliver it effectively. At our institution, low faculty engagement scores on an Accreditation Council for Graduate Medical Education (ACGME) survey prompted a residency-wide needs assessment, which revealed that most attendings provide feedback perceived by residents as ineffective. To address this, we developed a simulation-based faculty development program grounded in the “Debriefing with Good Judgment” model. Our study aims to evaluate whether this structured intervention can improve the quality and consistency of feedback …