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Articles 29191 - 29220 of 1791766
Full-Text Articles in Entire DC Network
The Multi-Hatted Court: Community Courts As Boundary Organizations, Peter Dixon, Hadar Dancig-Rosenberg
The Multi-Hatted Court: Community Courts As Boundary Organizations, Peter Dixon, Hadar Dancig-Rosenberg
Northwestern University Law Review
As a variety of the problem-solving court model, community courts have received significant scrutiny and debate. Do they help individuals by addressing the underlying needs that contribute to criminal behavior? Do they extend an unjust criminal legal system by making help conditional upon judicial involvement? This Article moves beyond such debates to ask how community court professionals and the communities who engage with them manage these and other tensions that are inherent to the model itself. As the second in a series of articles drawing on semi-structured interviews and focus groups with diverse stakeholders at the Red Hook Community Justice …
Unveiling The Patent Landscape Of Biologic Drugs, Michael D. Frakes, Melissa F. Wasserman
Unveiling The Patent Landscape Of Biologic Drugs, Michael D. Frakes, Melissa F. Wasserman
Northwestern University Law Review
It is undeniable that the escalating price of biopharmaceuticals is a critical issue, as high prices limit patients’ access to life-saving medications and strain our healthcare system. Biologics, or large-molecule drugs, which are revolutionizing modern healthcare, are significantly contributing to the escalating cost of prescription drugs. While biologic drugs represent only 2% of all U.S. prescriptions, they comprise close to 50% of net drug spending.
Policymakers have proposed a series of interventions to decrease drug prices that target the patent practices of pharmaceutical firms. Yet due to differences in law, we have a robust source of patenting information for small-molecule …
Does Textualism Constrain Supreme Court Justices?, James J. Brudney, Lawrence Baum
Does Textualism Constrain Supreme Court Justices?, James J. Brudney, Lawrence Baum
Northwestern University Law Review
A principal justification for textualism is the constraint hypothesis. Conservative Justices and leading textualist scholars contend that—in stark contrast to reliance on legislative history—focus on the ordinary meaning of enacted text leaves little room for the Justices to be policy-oriented or ideological in their interpretations. This Article represents the first systematic study probing the validity of the constraint hypothesis, one that employs both quantitative and qualitative analysis.
The Article examines the Justices’ reliance on interpretive resources in over 660 statutory decisions in the field of labor and employment, decided by the Burger Court, the Rehnquist Court, and the Roberts Court—during …
Weaving Healthcare Needs Of Maine Law Enforcement Officers With Exercise Is Medicine, Patricia Hubel
Weaving Healthcare Needs Of Maine Law Enforcement Officers With Exercise Is Medicine, Patricia Hubel
Doctorate in Kinesiology
A law enforcement officer’s health is impacted by an occupation of high stress, shift work, sleep disruption, mental stresses, and primarily sedentary work which is interrupted by brief periods of highly intense physical demands (Adams et al., 2010; Boyce et al., 2008, 2009). This descriptive study explored the use of exercise is medicine by primary care practitioners on patients who are law enforcement officers in the state of Maine. It also examined physical activity and health of the law enforcement officers. An online survey collected demographic data, responses from two validated surveys, and information from their last physical examination. The …
Stacking Moves: How Digital Platforms Sequence Value Creation, Jonathan M. Dickson
Stacking Moves: How Digital Platforms Sequence Value Creation, Jonathan M. Dickson
Undergraduate Honors Theses
This thesis examines how large digital platform firms evolve by adding new platform types over time. Using the four-type framework developed by Bryce, Dyer, and Van Alstyne—transaction, connection, innovation, and collaboration—I trace the platform histories of seven firms: Apple, Alphabet, Microsoft, Amazon, Meta, Tencent, and Alibaba. For each firm, I classify every qualifying platform event as a base platform, a stacking move (a new interaction that draws on an existing platform's users or architecture), or a standalone platform (a new platform that operates independently). Across seventy-plus events, four findings emerge:
- Firms stack new platform types in predictable sequences shaped by …
The Bankruptcy Revolving Door, Belisa Pang
The Bankruptcy Revolving Door, Belisa Pang
Northwestern University Law Review
The American consumer bankruptcy system is a costly regime with profound societal implications. Between 2008 and 2023, consumers filed 13.8 million bankruptcy cases across the ninety-four federal bankruptcy districts in the United States, generating over $4 billion in court filing fees alone. When accounting for attorney fees, trustee expenses, creditor costs, and broader economic externalities—such as increased interest rates borne by other consumers—the total financial impact easily reaches tens of billions, if not hundreds of billions, of dollars.
Against that backdrop, this study uncovers a startling phenomenon: nearly 46% of the consumers who filed bankruptcy in 2023 were repeat filers, …
Negligent Hiring: Recidivism And Employment With A Criminal Record, Benjamin Pyle
Negligent Hiring: Recidivism And Employment With A Criminal Record, Benjamin Pyle
Northwestern University Law Review
This Article tackles a difficult legal and policy challenge— reducing the impact of criminal records on job applicants’ chances in a manner that does not spur more discrimination—by looking at how another area of law, tort liability, impacts employers’ decision-making. It uses theoretical and empirical methods to study the most common reason employers report being reluctant to hire workers with a criminal record: legal liability generated by the tort of negligent hiring. While the purpose of the tort is ostensibly to protect and make whole those harmed when an employee misbehaves in a foreseeable manner, I show that, in practice, …
Medical Detection Dogs: A Visual Exploration Of Canine Olfactory Anatomy & Volatile Organic Compounds As Applied To Non-Invasive Biomedical Detection, Kirsten Santiago
Medical Detection Dogs: A Visual Exploration Of Canine Olfactory Anatomy & Volatile Organic Compounds As Applied To Non-Invasive Biomedical Detection, Kirsten Santiago
Theses
Medical detection dogs provide a non-invasive early method of disease and medical alert detection that is underrepresented in the medical visualization sector. The domesticated dog, or Canis familiaris, is known for its loving nature and has become an important member of many households, but they are also incredibly intelligent with a capacity for specialized training. Dogs have a specialized olfactory system, allowing them to detect scents with high acuity (Guest & Otto, 20). Volatile organic compounds or VOCs are molecular substances associated with metabolic processes that are often a result or byproduct of certain diseases and can be influenced by …
The Influence Of Presurgical Mandibular Incisor Inclination On The Stability Of Surgical Class Iii Patients: A Systematic Review, Houda Ousli, Youssef Oualalou, Fatima Zaoui, Asmae Bahoum
The Influence Of Presurgical Mandibular Incisor Inclination On The Stability Of Surgical Class Iii Patients: A Systematic Review, Houda Ousli, Youssef Oualalou, Fatima Zaoui, Asmae Bahoum
International Arab Journal of Dentistry
Objective: This study aims to assess the impact of presurgical mandibular incisor inclination on the stability of surgical class III patients.
Methods: An electronic search was conducted on PubMed, Scopus, Web of Science, EBSCO, and the Cochrane Library from 2014 to February 2025, initially identifying 351 publications relevant to our review.
Results: Four retrospective studies were included in this review, with the risk of bias ranging from low to serious. A preoperative retroinclined incisal axis leads to an increased post-surgical overjet and inadequate interincisal contact, indicating that retroclined mandibular incisors may affect skeletal stability. However, Overcorrection of mandibular incisor inclination …
Perceived Social Exclusion Among Mothers Of Autistic Children, Rahim Hamli Maraj, Zainab Hussein Dawood Salman
Perceived Social Exclusion Among Mothers Of Autistic Children, Rahim Hamli Maraj, Zainab Hussein Dawood Salman
Alustath Journal for Human and Social Sciences
Interaction with the environment is one of the basic pillars of the process of building civilization, as it represents the vital relationship between man and the surrounding nature. Investing in natural resources and harnessing them to serve society is what ensures the continuity and growth of civilizations. Hence, it becomes clear that any civilization cannot be built in isolation from the environment, as it is the incubator that provides man with raw materials, and it is also the field in which he tests his abilities to innovate and develop.The ancient Egyptian civilization is a prominent example of how to interact …
Utilising Reflective Journals As An Assessment Tool: A Case Study Of Kurdish Efl Post Graduate Students At Salahaddin University-Erbil, Qismat Mohammed Zahawi
Utilising Reflective Journals As An Assessment Tool: A Case Study Of Kurdish Efl Post Graduate Students At Salahaddin University-Erbil, Qismat Mohammed Zahawi
Alustath Journal for Human and Social Sciences
This study accentuates the notion that reflection profoundly aids students to profit from their own experiences. It aims at revealing Kurdish post-graduate students' perceptions toward utilising journal writing as an assessment tool. It also tries to uncover their language progress, metacognition, and self-awareness as a consequence of journal writing. Finally, it elicits challenges encountered by students when writing their journals. The current study is of qualitative-interpretive nature. Students' journal writing is the main tool of the study. Thematic analysis is carried out on data collected from reflective journals and a focus group interview including twelve Kurdish post-graduate students. Journaling resulted …
Radiation Doses To Cardiac Substructures Predict Elevation In High-Sensitivity Cardiac Troponin T Levels In Radiation Therapy For Lung Cancer, Xinru Chen, Xiaodong Zhang, Ting Xu, Radhe Mohan, Ruitao Lin, Mei Chen, Rachel C Maguire, Yao Zhao, Efstratios Koutroumpakis, Nicolas L Palaskas, Anita Deswal, Ali Ajdari, Joshua S Niedzielski, Sanjay S Shete, Laurence E Court, Jinzhong Yang, Zhongxing Liao
Radiation Doses To Cardiac Substructures Predict Elevation In High-Sensitivity Cardiac Troponin T Levels In Radiation Therapy For Lung Cancer, Xinru Chen, Xiaodong Zhang, Ting Xu, Radhe Mohan, Ruitao Lin, Mei Chen, Rachel C Maguire, Yao Zhao, Efstratios Koutroumpakis, Nicolas L Palaskas, Anita Deswal, Ali Ajdari, Joshua S Niedzielski, Sanjay S Shete, Laurence E Court, Jinzhong Yang, Zhongxing Liao
Faculty, Staff and Student Publications
Purpose: Cardiotoxicity is a major concern for patients undergoing thoracic radiation therapy. This study compared the predictive power of radiation dose-volume histogram (DVH) parameters and radiomic/dosiomic features of the whole heart (WH) and cardiac substructures for elevated circulating high-sensitivity cardiac troponin T (hs-cTnT), a biomarker for early detection of cardiac adverse events.
Methods and materials: A retrospective cohort of 160 patients with non-small cell lung cancer (NSCLC) from a completed prospective trial and a prospective cohort of 57 patients with NSCLC enrolled in an ongoing trial were analyzed. The endpoint was hs-cTnT elevation, indicated by an increase of ≥5 ng/L …
High Dietary Fiber Is Associated With Improved Outcomes In Patients With Melanoma And Sarcoma Treated With Immunotherapy Regardless Of Gut Microbiome Dysbiosis And Social Vulnerability, Brittany C Fields, Raymond S Traweek, Kai Jiang, Russell G Witt, Ashish Damania, Yi-Ju Chiang, Nadim Ajami, Elise Nassif-Haddad, Emily Z Keung, Manoj Chelvanambi, Xiaotao Zhang, Christine B Peterson, Jennifer A Wargo, Carrie R Daniel, Christina L Roland, Ashley M Holder
High Dietary Fiber Is Associated With Improved Outcomes In Patients With Melanoma And Sarcoma Treated With Immunotherapy Regardless Of Gut Microbiome Dysbiosis And Social Vulnerability, Brittany C Fields, Raymond S Traweek, Kai Jiang, Russell G Witt, Ashish Damania, Yi-Ju Chiang, Nadim Ajami, Elise Nassif-Haddad, Emily Z Keung, Manoj Chelvanambi, Xiaotao Zhang, Christine B Peterson, Jennifer A Wargo, Carrie R Daniel, Christina L Roland, Ashley M Holder
Faculty, Staff and Student Publications
Background: Social vulnerability, dietary fiber, and the gut microbiome have been individually implicated in clinical outcomes for melanoma and sarcoma patients. This study hypothesized that increasing social vulnerability is associated with insufficient dietary fiber intake and negatively associated with microbiome composition and clinical outcomes.
Methods: Clinicopathologic data, baseline fiber intake, and gut microbiome profiles were assessed in 153 patients with melanoma or sarcoma treated with immune checkpoint blockade (ICB) and prospectively followed. Patients' social vulnerability index (SVI) and fiber intake were evaluated for associations with microbiome composition, treatment response, and overall survival (OS).
Results: SVI percentile was 0.4 (interquartile ratio …
Engineering 50 Years From Today: A Purdue Engineering Community Perspective, Arvind Raman
Engineering 50 Years From Today: A Purdue Engineering Community Perspective, Arvind Raman
Purdue University Press Books
Since opening its doors in 1874, Purdue University’s College of Engineering and its graduates have been at the forefront of technological breakthroughs and are now poised to lead the next generation of engineers in the United States and around the globe. Featuring more than twenty-five essays from former Boilermakers, Engineering 50 Years From Today both celebrates the program’s 150th anniversary and looks ahead, exploring what the field of engineering might look like half a century from now. Leading luminaries from Purdue’s engineering community, including prominent university professors as well as innovators working in the private sector, reveal how technologies related …
Incidence Of Venous Thromboembolism In Women Receiving Transdermal Oestradiol/Testosterone With Micronised Progesterone In Accordance With Nice Guidelines, Amy Neville, Dan Reisel, John Benton, Mohit Khera, Louise Newson
Incidence Of Venous Thromboembolism In Women Receiving Transdermal Oestradiol/Testosterone With Micronised Progesterone In Accordance With Nice Guidelines, Amy Neville, Dan Reisel, John Benton, Mohit Khera, Louise Newson
Faculty, Staff and Students Publications
Background: Despite growing evidence supporting the long-term safety of hormone replacement therapy (HRT), concerns persist about certain adverse health outcomes, including venous thromboembolism (VTE). The aim of the study is to evaluate the risk of VTE in peri- and postmenopausal women treated with transdermal 17β-oestradiol with micronised progesterone or intrauterine progesterone (levonorgestrel) via the Mirena coil, in a real-world clinical setting.
Methods: The study included peri- and postmenopausal women attending a private menopause clinic between January 1, 2023, and December 31, 2023. Patients were actively undergoing treatment with transdermal oestradiol and progesterone in the form of micronised oral progesterone or …
Misregulated Alternative Splicing In Endometriosis: A Role For Aberrant Mrna Variants In Endometriotic Cell Growth, Venkata Naga Goutham Davuluri, Michelle Dias, Roxanna Llinas, Kamath Neha, Pooja Popli, Shannon M Hawkins, Chandrakant Tayade, Elise T Courtois, Hari Krishna Yalamanchili, Ramakrishna Kommagani
Misregulated Alternative Splicing In Endometriosis: A Role For Aberrant Mrna Variants In Endometriotic Cell Growth, Venkata Naga Goutham Davuluri, Michelle Dias, Roxanna Llinas, Kamath Neha, Pooja Popli, Shannon M Hawkins, Chandrakant Tayade, Elise T Courtois, Hari Krishna Yalamanchili, Ramakrishna Kommagani
Children’s Nutrition Research Center Staff Publications
Endometriosis is a chronic gynecological disorder marked by the growth of endometrial-like tissue outside the uterus, often leading to pelvic pain, inflammation, and infertility. Despite its global prevalence, diagnosis remains delayed, and effective non-surgical treatments are lacking. While recent transcriptomic studies have identified mRNA transcript changes in ectopic lesions, the contribution of alternative pre-mRNA splicing, a key posttranscriptional regulatory layer, remains largely unknown. In this study, we performed a comprehensive analysis of alternative splicing (AS) events in endometriotic lesions using transcriptomic data. We uncovered distinct alterations in alternative splicing events are associated with endometriosis, highlighting a previously underappreciated layer of …
Primary Apocrine Adenocarcinoma Of The Vulva: A Report Of A Rare Case, Marcus Yoakam, Jesse Friday, Andrea Weitoschova, Kalyn Borger, Drew Windsor, Brett Dunbar, Victoria Shirley
Primary Apocrine Adenocarcinoma Of The Vulva: A Report Of A Rare Case, Marcus Yoakam, Jesse Friday, Andrea Weitoschova, Kalyn Borger, Drew Windsor, Brett Dunbar, Victoria Shirley
Student Publications
Primary apocrine adenocarcinoma of the vulva is a rare and aggressive malignancy that typically presents as an irregular vulvar lesion with associated dermatologic changes. Diagnosis can be challenging due to significant clinical and histopathologic overlap with other vulvar adenocarcinomas as well as metastatic disease. We present the case of a 63-year-old postmenopausal woman diagnosed with primary apocrine adenocarcinoma of the vulva. The patient’s prior history of breast cancer created a diagnostic dilemma, as it was initially unclear whether the lesion represented metastatic breast carcinoma or a primary vulvar malignancy. Histopathologic evaluation with immunohistochemical analysis demonstrated strong androgen receptor positivity, negative …
Mind–Body Medicine Training For Incarcerated Men And Women, Julie K. Staples, Jesse Rice, Kathleen S. Farah, Sabrina N'Diaye, James S. Gordon
Mind–Body Medicine Training For Incarcerated Men And Women, Julie K. Staples, Jesse Rice, Kathleen S. Farah, Sabrina N'Diaye, James S. Gordon
Student Publications
Background/Objective: Mind–body programs teaching mindfulness-based techniques have benefits for incarcerated people, as do programs in which individuals teach yoga to their incarcerated peers. However, there are no studies of comprehensive programs that combine a variety of self-care techniques with group support and enable people in prison to enhance their own well-being and then share what they have learned with their peers. This study evaluated the effects of such a training program in the United States. Methods: Thirty-eight incarcerated men and women began the 8-day mind–body medicine training and 31 completed the training. Mind–body techniques taught included soft belly breathing, meditation, …
Embodied Transcendence: Psychedelics And The Evolution Of Moral Abstraction, Emanuel Jas
Embodied Transcendence: Psychedelics And The Evolution Of Moral Abstraction, Emanuel Jas
Journal of Conscious Evolution
This paper explores the role of psychedelics in the context of evolutionary brain development and the conceptual capacity for moral realism. Drawing on theories from evolutionary anthropology, neuroscience, and moral philosophy, the first part provides a brief overview of human evolution and brain expansion. From here, recent empirical data from the neurosciences is assessed on the effect psychedelics have on the brain, along with speculations on the role of psychedelics in our hominoid evolutionary history—specifically, the capacity for phenomenologically rich, conscious, subjective experiences that are incredibly vivid and real. This imaginative capacity for transcendence and disembodiment could enable the realization …
Targeted Therapy In Hepatobiliary Pancreatic Cancer (Hpc): Advantages And Advancements Of Antibody Drug Conjugates, A Type Of Chemo-Biologic Hybrid Drugs, Tushar Deb Nath, Attrayo Mukherjee, Subhash Chauhan, Debasish Bandyopadhyay
Targeted Therapy In Hepatobiliary Pancreatic Cancer (Hpc): Advantages And Advancements Of Antibody Drug Conjugates, A Type Of Chemo-Biologic Hybrid Drugs, Tushar Deb Nath, Attrayo Mukherjee, Subhash Chauhan, Debasish Bandyopadhyay
School of Integrative Biological & Chemical Sciences Faculty Publications
Currently, there are very few efficient treatment options for hepatobiliary pancreatic cancer (HPC), which comprises pancreatic ductal adenocarcinoma (PDAC), biliary tract cancer (BTC), and hepatocellular carcinoma (HCC). The HPC tumors are the most lethal malignant tumors in the world. Traditional chemotherapy offers little survival benefit and is associated with notable systemic toxicity, which has made antibody–drug conjugates (ADCs) a hopeful treatment option. Strong cytotoxic drugs combine with monoclonal antibodies to attack tumor-associated antigens. This review discusses the benefits and current developments of Antibody–Drug Conjugates (ADCs) in treating HPC. It also covers their mechanisms of action, ongoing clinical trials, and the …
Speleoco: An Open, Low-Cost Arduino Co₂ Datalogger For Cave Microclimate Monitoring, Christos Pennos, Dimitrios Christaras
Speleoco: An Open, Low-Cost Arduino Co₂ Datalogger For Cave Microclimate Monitoring, Christos Pennos, Dimitrios Christaras
International Journal of Speleology
Carbon dioxide (CO₂) dynamics in caves are critical for karst processes, speleothem growth and dissolution, microclimate regulation, and caver safety. In cave atmospheres, CO₂ commonly derives from soil respiration, epikarst degassing, microbial activity, and, in tectonically active regions, deep-seated fault-related emissions. Fault-related CO₂ degassing may also track tectonic activity. However, continuous monitoring remains limited due to the cost and inflexibility of commercial instruments. Here we present an open-source, low-cost Arduino-based CO₂ datalogger designed for cave applications. The logger integrates a COZIR NDIR CO₂ sensor, a DS1337 real-time clock, microSD storage, and power-gating for extended deployment in humid environments. Firmware and …
Cemented Femoral Fixation In A High-Risk Periprosthetic Fracture Cohort – A Case Series, John Spak, Philip C. Aurigemma, Yaser C. Rahim
Cemented Femoral Fixation In A High-Risk Periprosthetic Fracture Cohort – A Case Series, John Spak, Philip C. Aurigemma, Yaser C. Rahim
The Lahey Journal
Introduction:
Periprosthetic femur fractures (PPFx) are a major cause of early revision after total hip arthroplasty (THA), accounting for nearly 20% of early failures. Cementless fixation, though widely used, has been associated with an increased risk of early PPFx, particularly in elderly or osteoporotic patients. Cemented femoral fixation may reduce this risk in high-risk populations.
Case Presentation:
We performed a retrospective review of 430 consecutive primary THAs conducted between July 2022 and July 2025 at a single institution. Cementless fixation was used in 390 patients and cemented fixation in 40 high-risk patients (mean age 81.7 vs. 65.9 years; BMI 24.5 …
Simulated Hearing Loss In Healthy Young And Older Adults Results In Poor Reaction Time In Older Adults., Victoria Kowalewski, Nicoleta Bugnariu, Rita M. Patterson, Jessica Hartos
Simulated Hearing Loss In Healthy Young And Older Adults Results In Poor Reaction Time In Older Adults., Victoria Kowalewski, Nicoleta Bugnariu, Rita M. Patterson, Jessica Hartos
Pacific Journal of Health
Emerging evidence links hearing loss to increased fall risk in older adults, yet mechanisms remain unclear. This study examined the impact of simulated hearing loss on reactive balance control in healthy young and older adults. Participants performed dual-task scenario involving auditory sentence repetition and unexpected surface translations. Hearing loss was simulated using Adobe Audition, applying frequency-specific attenuation based on moderate sensorineural hearing loss levels from the literature.
Speech-in-noise performance significantly declined under simulated hearing loss for both age groups (p < .001), confirming effective simulation, but not significant differences were found between age groups. Maximum COP-COM displacement (the scalar distance between Center of Pressure and Center of Mass) increased with perturbation intensity (Level 1 vs. Level 2: p < .001), but no significant differences were found between hearing conditions or age groups (p > .05), suggesting compensatory step execution was preserved.
Reaction time analysis revealed a significant interaction between hearing condition and perturbation level …
Real-World Comparison Of Intravenous Vs. Oral Antimicrobial Therapy For Bone And Joint Infections, Maura Kreiser, Sarah Al Mansi, Ismaeel Yunusa Ph.D., Caroline Derrick, P. Brandon Bookstaver Pharm.D., Majdi N. Al-Hasan, Yorika Hammett, Morgan Pizzuti
Real-World Comparison Of Intravenous Vs. Oral Antimicrobial Therapy For Bone And Joint Infections, Maura Kreiser, Sarah Al Mansi, Ismaeel Yunusa Ph.D., Caroline Derrick, P. Brandon Bookstaver Pharm.D., Majdi N. Al-Hasan, Yorika Hammett, Morgan Pizzuti
Faculty Publications
Well-designed randomized controlled trials (RCTs) have demonstrated safe and effective use of oral antimicrobial therapy for bone and joint infections. Application of data for implementation into real-world practice, however, has inherent challenges. This retrospective cohort study compared real-world use of intravenous versus oral antimicrobial therapy in bone and joint infections within a large healthcare system comprising both academic and community medical centers. The primary outcome was the proportion of treatment failure. Key secondary outcomes included the proportion of patients with logistical failure and risk factors associated with treatment and logistical failure. Among 166 patients included, 136 (82%) and 30 (18%) …
Cell Type-Specific Enhancers Regulate Il-22 Expression In Innate And Adaptive Type 3 Lymphoid Cells, Ankita Saini, Leone S Hopkins, Vanida A Serna, Matthew V D Mccullen, Nicholas G Selner, Bishan Bhattarai, José L Fachi, Rebecca A Glynn, Katharina E Hayer, Craig H Bassing, Marco Colonna, Eugene M Oltz
Cell Type-Specific Enhancers Regulate Il-22 Expression In Innate And Adaptive Type 3 Lymphoid Cells, Ankita Saini, Leone S Hopkins, Vanida A Serna, Matthew V D Mccullen, Nicholas G Selner, Bishan Bhattarai, José L Fachi, Rebecca A Glynn, Katharina E Hayer, Craig H Bassing, Marco Colonna, Eugene M Oltz
2020-Current year OA Pubs
IL-22, a signature cytokine for type 3 lymphoid cells, including T helper 17/22 (Th17/22) and type 3 innate lymphoid cells (ILC3), mediates epithelial homeostasis and protective pathogen responses in barrier tissues. Upon dysregulation, IL-22 can drive chronic inflammatory diseases, yet little is known about transcriptional elements modulating its expression. Here, we identify two enhancers, E22-1 and E22-2, with distinct capacities for regulating Il22 expression in type 3 lymphoid cells. Both enhancers are necessary for protection from Citrobacter rodentium infection and for the onset of IL-22-mediated psoriasis. E22-2 is specifically required for IL-22 expression in ILC3s, while E22-1 functions in both …
The Relationship Between Guilt And Self-Blame With Early Maladaptive Schemas In Patients With Cancer: A Cross-Sectional Study, Mohadeseh Nikandish, Seyede Salehe Mortazavi, Shahrbanoo Ghahari, Mahdiyeh Salehi, Roghie Bagheri
The Relationship Between Guilt And Self-Blame With Early Maladaptive Schemas In Patients With Cancer: A Cross-Sectional Study, Mohadeseh Nikandish, Seyede Salehe Mortazavi, Shahrbanoo Ghahari, Mahdiyeh Salehi, Roghie Bagheri
Sultan Qaboos University Medical Journal
Objectives: Cancer is still one of the leading causes of death worldwide and a high percentage of patients with cancer face emotional challenges such as guilt and self-blame. Early maladaptive schemas (EMSs) can make these feelings even stronger. This study aimed to explore how guilt and self-blame relate to EMSs in individuals with cancer, while taking overall psychological distress into account. Methods: This cross-sectional study was conducted at Rasoul-e-Akram and Firoozgar hospitals in Tehran, Iran, from October 2022 to June 2023. Patients with cancer answered the Early Maladaptive Schema Questionnaire-Short Form, Eysenck's Guilt Questionnaire (2007) and the Cognitive Emotion Regulation …
Advancements In Extracellular Vesicle Research, Lucia R. Languino
Advancements In Extracellular Vesicle Research, Lucia R. Languino
Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers
The AAEV (American Association of Extracellular Vesicles) Annual Meeting at the John P. McGovern Commons in Houston, TX convened over 300 leading re- searchers, clinicians, and industry experts from around the world to advance the rapidly evolving field of extracellular vesicle (EV) science. EVs, nanoscale lipid- bound particles released by all prokaryotic and eukaryotic cells, have emerged as crucial mediators of intercellular communication, trans- porting proteins, nucleic acids, and lipids that influence a wide spectrum of physiological and pathological processes. Their involvement in immune modulation, tissue regeneration, cancer progression, metabolic regulation, and other complex biological functions positions EVs as promising …
Knee Arthroscopy Versus Magnetic Resonance Imaging In The Diagnosis Of Acl Injury – A Comparative Study, Hussein Habeeb Mhawesh, Ayoub Yosif Hamdan, Ahmed Khalaf Hamad, Alseddiq Oday Latof
Knee Arthroscopy Versus Magnetic Resonance Imaging In The Diagnosis Of Acl Injury – A Comparative Study, Hussein Habeeb Mhawesh, Ayoub Yosif Hamdan, Ahmed Khalaf Hamad, Alseddiq Oday Latof
Hilla University College Journal For Medical Science
Background: Accurate diagnosis of anterior cruciate ligament (ACL) injuries is critical for selecting appropriate treatment strategies and preventing long-term knee dysfunction. Magnetic resonance imaging (MRI) is widely used as a non-invasive diagnostic tool, while arthroscopy remains the gold standard. Objectives: This study aimed to compare the diagnostic accuracy of MRI against arthroscopic findings in ACL injuries and to assess its current performance in clinical settings for the years 2024–2025. Methods: A total of 40 patients (31 males, 77%; 9 females, 23%) aged 20–50 years (median age 35 years) who presented with suspected ACL injury were enrolled. All patients underwent MRI …
Childhood Cancer In Al-Najaf Governorate, Iraq: Trend Analysis From 2020 To 2023, Sahar Hassan, Hasan Alwan Baiee, Faten Ali Abd-Alzahra Albarki, Rajaa Ali Moheiseen Al-Taee, Mustafa Muqdad
Childhood Cancer In Al-Najaf Governorate, Iraq: Trend Analysis From 2020 To 2023, Sahar Hassan, Hasan Alwan Baiee, Faten Ali Abd-Alzahra Albarki, Rajaa Ali Moheiseen Al-Taee, Mustafa Muqdad
Hilla University College Journal For Medical Science
Background: The lack of comprehensive cancer registries and underreporting of cases may further complicate efforts to assess disease patterns and implement effective control measures. Objectives: This study aims to analyze cancer trends in Al-Najaf Governorate, Iraq from 2020 to 2023, addressing gaps in local data and providing insights that could inform future healthcare strategies and resource allocations. Methods: A retrospective, cross-sectional study was conducted using data from the Middle Euphrates Oncology Center and the Statistics Department for Cancer Research at Al-Najaf General Health Directorate. The study included children younger than 18 with histologically and hematologically verified cancer from January 2020 …
Caregiver Burden And Associated Socioeconomic And Clinical Factors Among Parents Of Pediatric Type 1 Diabetes Patients In Sulaymaniyah, Iraq, Dyari Saleem Ismael Ali, Bahar Nasradeen Majeed
Caregiver Burden And Associated Socioeconomic And Clinical Factors Among Parents Of Pediatric Type 1 Diabetes Patients In Sulaymaniyah, Iraq, Dyari Saleem Ismael Ali, Bahar Nasradeen Majeed
Hilla University College Journal For Medical Science
Background: Type 1 Diabetes Mellitus (T1DM) in children imposes a significant caregiving burden on parents, affecting their psychological and social well-being. Understanding this burden and its associated factors is crucial for improving family-cantered diabetes care. Objectives: This study aimed to assess the level of caregiver burden among parents of children with type 1 diabetes mellitus (T1DM) and explore its association with sociodemographic, clinical, and management-related factors. Methods: A quantitative cross-sectional study was conducted at Dr. Jamal Ahmad Rashid Pediatric Teaching Hospital in Sulaymaniyah, Iraq, between November 2024 and February 2025. A total of 160 parents of children with T1DM were …