Digital Commons Network^™

4-Aminoquinolines Block Heme Iron Reactivity And Interfere With Artemisinin Action, Melissa Rosenthal, Daniel E Goldberg

2020-Current year OA Pubs

Artemisinin-based combination therapies (ACTs) remain the mainstay of treatment for

The Echo: March 23, 2026, Taylor University

2025-2026 (Volume 113)

No abstract provided.

Γδ T Cells At The Interface Of Innate And Adaptive Immunity In Cancer, Arnau Solé Casaramona, Martin F Bachmann, Eva Sevick-Muraca, Mona O Mohsen

The Brown Foundation: Institute of Molecular Medicine

γδ T cells are unconventional lymphocytes that bridge innate and adaptive immunity by combining recognition of stress-induced ligands independently of classical major histocompatibility complex molecules with the capacity to undergo clonal expansion and long-term adaptation. Their unusual ability to detect malignant transformation using semi-invariant T-cell receptors, butyrophilin recognition and natural killer-like receptors positions them as powerful effector cells in tumors that evade classical immune escape mechanisms. Furthermore, distinct γδ subsets have distinct phenotyping and specific tissue-residencies, which could be leveraged to modulate immunological responses. We evaluate engineered therapies and different experimental platforms for studying γδ T cell biology. We conclude …

Modern Dna Detection Via Traditional Methods: Conforming Algal Species In Soran Independent Administration, Kurdistan Region Of Iraq, Balkes Haje Rasul, Farhad Hassan Aziz, Janan Jabbar Toma

Baghdad Science Journal

This investigation was conducted on five genetically identified algal species at five sites in the Soran administration, with sampling monthly from March 2024 to January 2025. Accurate species identification is essential for understanding biodiversity, assessing ecosystems, and managing water quality. Traditional morphological identification is standard practice for algal characterization, but these methods are time-consuming and error-prone, especially when dealing with similar-looking species or mixed populations. Modern DNA detection methods, including polymerase chain reaction (PCR) and DNA barcoding, improve specificity and sensitivity. This study compares the effectiveness of DNA detection methods with traditional morphological techniques to confirm the presence of five …

Discordance Between Actual And Perceived Balance Ability Relates To Quality Of Life And Global Cognition In A Clinical Sample Of Parkinson Patients, Daniel S. Peterson, Jason K. Longhurst, Franziska Albrecht, Joanna Weller, Jennifer Vasquez, Myassar Zarif, Mark Gudesblatt, Andrew Hooyman

Physical Therapy Faculty Articles and Research

Background

Objective

Methods

Improving Depression Screening For African American Adolescents Through Staff Education On The Phq-A, Yvonne Anutatu Nkeze

Walden Dissertations and Doctoral Studies

Improving Depression Screening for African American Adolescents Through Staff Education on the PHQ-A

Circulating Levels Of Insulin-Like Growth Factor I (Igf-I) And Risk Of Multiple Myeloma: An Observational And Mendelian Randomisation Study, Yolanda Benavente, Sara Hermosa, Nikos Papadimitriou, Alyssa I. Clay-Gilmour Ph.D., Elizabeth E. Brown, Jonathan N. Hofmann, Nathaniel Rothman, Qin Lan, Sonja I. Berndt, Demetrius Albanes, Mark Purdue, Mitchell J. Machiela, Stephen J. Chanock, Parveen Bhatti, Wendy Cozen, Aaron Norman, Susan L. Slager, James R. Cerhan, Vincent Rajkumar, Et. Al.

Faculty Publications

No abstract provided.

Mastr-Seq Enables Multiplexed Analysis Of Short Tandem Repeats With Sequencing, Chuanbin Su, Han-Seul Ryu, Keerthivasan Raanin Chandradoss, Thomas Malachowski, Ravi Boya, Linda Zhou, Hoa Emma Nguyen, Esteban O Mazzoni, Kristen J Brennand, Jennifer E Phillips-Cremins

2020-Current year OA Pubs

More than 60 human disorders are caused by unstable expansion of short tandem repeat (STR) tracts. These can exhibit cell-type-specific mosaicism in several repeat expansion disorders and remain difficult to characterize due to technical challenges intrinsic to highly repetitive sequences. Long-read approaches can measure STR length and DNA methylation on the same single molecule but are low-throughput and cost-prohibitive across multiple experimental conditions or patient samples. Here, we present MASTR-seq, multiplexed analysis of short tandem repeats with sequencing, for cost-effective, high-throughput, accurate measurement of STR genotype and DNA methylation at single-allele resolution. MASTR-seq couples long-read sequencing, Cas9-mediated target enrichment, size …

Tlr3 Mediated Type I Interferon Response In Mammalian Cell Defense Against Cryptosporidium Parvum Infection., Anjelica Matias

Biochemistry and Molecular Biology

Cryptosporidium parvum is a major cause of a diarrheal disease which affects many children in the USA as well as the rest of the world, yet the contribution of its double stranded RNA (dsRNA) viral symbiont, Cryspovirus (CSpV1) to host innate immunity remains unclear. This study investigated whether CSpV1 activates Toll Like Receptor 3 (TLR3) signaling pathways and downstream Interferon type I (IFN I) responses in mammalian intestinal epithelial cells. Confluent Human Ileocecal Colorectal Adenocarcinoma cells (HCT8) were exposed to CSpV1, and the expression levels of Tumor Necrosis Factor Receptor-Associated Factor 3 (TRAF3), Nuclear Factor-𝜅-light chain enhancer of activated B-cells …

Usa V. Nicole Schuster

2026 Decisions

USDC for the Eastern District of Pennsylvania

Associations Between Reported Use Of Nutritional Labels And Calorie Intake In Us Adults: Findings From Nhanes 2017–2020, Ariana M. Chao, Nancy Greene, Alexandra Paul, Paule V. Joseph

College of Nursing Faculty Papers & Presentations

Objective: Caloric information is commonly displayed on nutritional fact labels and food menus. Yet evidence is limited on whether label use is associated with a reduced-calorie diet. This study examined the associations between the use of caloric information on nutritional facts and menu labels and daily caloric intake. Methods: We used data from adults in the National Health and Nutrition Examination Survey (NHANES) 2017–2020 to conduct a cross-sectional study. Calorie label use on nutritional labels and menus was assessed using the Flexible Consumer Behavior Survey telephone interview. Caloric intake was evaluated using the mean of two 24-h diet recalls implemented …

Unpacking Low Glycaemic Index (Gi) Food Purchase Intentions In An S-O-R Framework: The Multidimensional Moderating Roles Of Consumer Knowledge And Trust, Cao Henglei

Student Works (2020-2029)

Research aim: Examine Malaysian consumers’ decisions to purchase low-GI foods using the S–O–R framework, while considering how knowledge and trust shape these decisions. Design/Methodology/Approach: A quantitative survey was conducted among 302 Malaysian consumers, with data analysed via confirmatory factor analysis, structural equation modelling, and moderation analysis. Research findings: Attitudes toward low-GI foods are shaped by health consciousness, environmental concern, and social influence, but not price perception. Purchase intention is directly influenced by trust, with moderation observed only for subjective knowledge. Theoretical contribution/Originality: Extends the S–O–R framework through differentiating knowledge type and clarifying the role of trust in low-GI food consumption. …

Assessment Of Early Breast Cancer Response To Chemotherapy With Ultrasound Radiomics, Swapnil Dolui, Basak Dogan, Corinne Wessner, Jessica Porembka, Priscilla Machado, Bersu Ozcan, Nisha Unni, Maysa Abu-Khalaf, Flemming Forsberg, Kibo Nam, Kenneth Hoyt

Department of Medical Oncology Faculty Papers

Objective: This prospective study investigated the use of H-scan ultrasound (US) imaging as a novel component of a multiparametric radiomic analysis framework for characterizing human breast cancer response to neoadjuvant chemotherapy (NAC) before and early after treatment initiation. Methods: Thirty breast cancer patients scheduled for NAC were scanned using a clinical US system (Logiq E9, GE HealthCare) equipped with a 9L-D linear array transducer. Radiofrequency (RF) data was obtained at baseline (pre-NAC) and after 10% and 30% of the complete dose of chemotherapy. The RF data was analyzed by a bank of 256 frequency-shifted bandpass filters to form H-scan US …

Braiding Epistemologies: A Testimonio Of A Woman Of Color Coach Creating Space In California Community College Athletics, Erika Marie Vargas

Dissertations

This qualitative ethnographic study examined the experiences of one woman of color intercollegiate coach navigating her path to a head coaching position within the California Community College (CCC) system using testimonio. Drawing on interviews with the head coach, her mentor, assistant coach, and a former athlete supported by ethnographic fieldnotes, the study analyzed her experiences through Critical Race Theory, Black Feminist Epistemology, Chicana Feminist Epistemology, and a newly articulated Indigenous Feminist Epistemology centered on relational accountability, embodied knowledge, ancestral grounding, and community responsibility. Findings show that her coaching developed within institutional structures not designed for women of color. She navigated …

The Rider (2026-03-23), Daniela Chapa-Reyes

The Rider Archives

Vol. 11, No. 23

Intouch Week Of March 23, 2026, New York Medical College

InTouch

• Match Day Marks a New Season of Growth for the Class of 2026
• NYMC Explores the Lasting Impact of Marie Curie at Women’s History Month Event
• Department of Public Health Introduces New Certificate Option
• NYMC Teams Shine at Inaugural RISE Case Competition
• New Vein-Harvesting Technique Could Reduce Bypass Graft Failure
• Spring Into Publishing: Meet the Experts
• Student Spotlight: Exploring Connections Between Alzheimer's Disease and Glaucoma

Academic Policies Committee Minutes Of The Academic Senate 2026-03-23, University Of Dayton. Academic Senate. Academic Policies Committee

All Committee Minutes

Approved minutes of a meeting of the Academic Policies Committee of the Academic Senate of the University of Dayton

A Mitochondrial Plasma Proteomic Signature Identifies Metastatic Chromophobe Renal Cell Carcinoma, Clara Steiner, Tiegang Han, Steven Safi, Wafaa Bzeih, Hadi Mansour, Eddy Saad, Jessica F. Williams, Vinay K. Giri, Liliana Ascione, Yehonatan Elon, Adam P. Dicker, Yan Tang, Toni K. Choueiri, Elizabeth P. Henske, Wenxin Xu

Department of Radiation Oncology Faculty Papers

BACKGROUND: Chromophobe renal cell carcinoma (ChRCC) is characterized by the accumulation of abnormal mitochondria, a high rate of mitochondrial DNA (mtDNA) mutations, and altered oxidative metabolism. There are no existing circulating biomarkers to distinguish metastatic ChRCC from clear cell renal cell carcinoma (ccRCC).

METHODS: High-throughput plasma proteomic profiling using the SomaScan platform was performed in 18 ChRCC (including 16 metastatic ChRCC) and 197 metastatic ccRCC patients. Data were harmonized to generate a unified 7K-protein matrix.

RESULTS: Differential expression analysis was performed using limma (version 3.62.2). Of 7272 quantified human plasma proteins, 209 were differentially expressed between ChRCC and ccRCC. Upregulated …

Sars-Cov-2 Nonspike Structural Proteins Hijack Mucosa Epithelial Cell Fate, Yan Gao, Lucas Lacerda Souza, Hong Soon Kang, Zehan Li, Juan Carlos Hernandez-Guerrero, Fábio Abreu Alves, Wei Zhang, Vikram Sharma, Sally Hanks, Jinhua Yu, Christopher Tredwin, Anton M. Jetten, Ciro Dantas Soares, Bing Hu

Peninsula Dental School

COVID-19 patients readily present with severe epithelial damage, such as tissue ulceration and erosion, along with disrupted tissue repair, in multiple organs. The mucous membranes of the lung alveoli [1, 2], gastrointestinal tract [3, 4], nasal [5] and oral cavity [6, 7] are the primary targets of the SARS-CoV-2 virus. The infected epithelium triggers a dysregulated immune response that further damages tissues and organs [8, 9–10]. Increasing evidence suggests that the SARS-CoV-2 virus can cause direct damage to epithelial cells and fibroblasts [11, 12–13]. Here, we report that the mucosa epithelia of COVID-19 patients can undergo cellular dedifferentiation before any …

Antimicrobial Activity Of Sulbactam-Durlobactam Against Acinetobacter Baumannii-Calcoaceticus Complex Strains Causing Non-Respiratory And Non-Bloodstream Infections From The United States (2023–2025), Elizabeth Cyr, Jill Argotsinger, Eric T Beck, Robin R Chamberland, Andrew E Clark, Anne R Daniels, Rachael Liesman, Mark Fisher, Philip Gialanella, Jonathan Hand, Amanda T Harrington, Romney M Humphries, Holly Huse, Robert Hamilton-Seth, Julia D Hankins, Wesley D Kufel, Scott W Riddell, Meera Mehta, Ryan Demkowicz, A Brian Mochon, Hossein Salimnia, Ayesha Khan, Virginia M Pierce, Raghava Potula, Tsigereda Tekle, Patricia J Simner, Robert J Tibbetts, Christine Vu, Lilian M Abbo, Octavio Martinez, Rebekah E Dumm, Manohar B Mutnal, Timothy C Jenkins, Violeta Chávez, Paulette Pinargote, Jennifer Bowling, Erik Munson, Daniel V Zurawski, David P Nicolau, Tomefa E Asempa, On Behalf Of The Acinetobacter Baumannii Complex National Biorepository (Acnbio) Study Group

Faculty, Staff and Student Publications

Acinetobacter baumannii most often causes pneumonia in critically ill patients. However, A. baumannii is also an important cause of a broader range of infections, including skin/wound and urinary tract infections. This study aims to evaluate the in vitro activity of sulbactam-durlobactam and comparator antibiotics, including meropenem and cefiderocol against A. baumannii-calcoaceticus complex isolates from non-respiratory and non-bloodstream sources. Samples included 285 A. baumannii-calcoaceticus complex isolates enriched for carbapenem resistance collected across 17 states in the United States (January 2023–May 2025). Antimicrobial susceptibility tests were conducted by manual broth microdilution and interpreted according to Clinical and Laboratory Standards Institute (CLSI) and …

A Retrospective Analysis Of Taxane-Based Chemotherapy In Small Bowel Adenocarcinoma, Mir Lim, Nikhil Grandhi, Preksha Shah, Kanwal Raghav, Victoria Serpas, Maria Pia Morelli, Katrina Pedersen, Aparna Kalyan, Mohamed Salem, Ryan Huey, John Paul Shen, Huamin Wang, Hua Wang, Anjali Vinocha, Jane Thomas, Robert Wolff, Michael J Overman

Faculty, Staff and Student Publications

Background: Small bowel adenocarcinoma (SBA) is molecularly distinct from colorectal and gastric cancers, yet treatment typically parallels colorectal cancer. We evaluated the activity of taxane-based therapy in the largest SBA cohort to date.

Methods: We retrospectively reviewed SBA patients treated with taxane-based chemotherapy at MD Anderson Cancer Center from 1994-2024. Eligible patients had pathologic confirmation, received >1 treatment cycle, and had tumor response evaluation. Survival analyses were analyzed using Kaplan-Meier and Cox proportional hazard models.

Results: Seventy patients were identified. Median age was 57, and 59% were male. Primary sites were duodenum (44%), jejunum (34%), and Ileum (16%). Metastatic sites …

Brown-Reid V. Jucida

All Decisions

In this Small Claims action for five months' unpaid rent, the court awarded judgment for the plaintiffs. Defendants' mold and harassment defenses were barred by res judicata based on a prior HP proceeding in which defendants were awarded damages. The retaliatory eviction defense under RPL § 223-b was unavailable because the premises is a two-family, owner-occupied dwelling with fewer than four units, expressly exempted under RPL § 223-b(6).

Exploring And Identifying The Challenges And Successes Of Reintegration Experiences Of Bipoc Female Veterans, Ruby Screen

JWU Dissertations & Theses

The reintegration experiences of BIPOC female veterans remain underrepresented in scholarship and policy discourse, despite evidence of race, gender, and veteran status intersect to shape post-service outcomes (Fox, 2019; Hunt & Aggad, 2024). Existing research has largely centered on male or non-minoritized veterans, limiting understanding of how structural inequities influence employment, healthcare access, community integration, and psychological well-being for BIPOC women (Lawrence et al., 2021). This gap constrains the development of culturally responsive policies and support systems. Guided by intersectionality theory (Crenshaw, 1989) and reintegration frameworks (Sayer et al., 2011), this primarily quantitative study, supplemented with open-ended survey responses, examined …

Potential Role Of Mir-484 In Modulating Vdr Gene Expression Level In Calcium Oxalate Kidney Stone Patients, Huda B. Babat, Luma Hassan Alwan Alobaidy, Issam Salman Al-Azzawi

Baghdad Science Journal

Calcium oxalate (CaOx) kidney stones, accounting for over 70% of all types, are the most common stone type. MicroRNAs (miRNAs) are post-transcriptional epigenetic regulators, involved in disease development. One of these miRNAs is miRNA 484 (miR-484). Vitamin D (VD), a fat-soluble vitamin important for calcium (Ca) metabolism, is primarily mediated by the Vitamin D Receptor (VDR), a nuclear transcription factor. This study aimed to investigate miR-484's regulatory role in modulating VDR gene expression, evaluate serum VD and biochemical parameters in CaOx kidney stone patients compared to healthy controls, and their potential as diagnostic biomarkers. Blood samples were collected …

Seasonal Variation And Spatial Distribution Of Heavy Metals In Groundwater: Implications For Water Quality And Health Risks, Muzhda Qasim Qader, Shevan Jamel Jirjees, Masoud H. Hameed, Chiyai Maroof Sharif

Baghdad Science Journal

Background: This study evaluated the seasonal and spatial distribution of twelve heavy metals in the groundwater samples collected in fifty wells with the aim of assessing the quality of water and health hazards associated with it. The data were analyzed to compare the wet and dry seasons were the analytical data using pollution indices, the Nemerow Pollution Index (NPI), and the Single-Factor Pollution Index (SFPI). The results revealed that the water quality was mainly excellent (NPI < 0.01) even though in some areas, lead, vanadium, and copper were contaminated. Arsenic (0.0008–0.0145 μg/L), chromium (0.0009–0.0096 μg/L), and nickel (

An Age-Structured Model For The Effects Of Time Delay On The Dynamics Of Malaria In The Presence Of Temperature And Rainfall, Alanus Mapunda, Eunice Mureithi, Nyimvua Shaban

Tanzania Journal of Science

An age-structured model with a class of pregnant women that captures the impact of time-delay on the dynamics of malaria is established in this work. The main goal is to explore the transmission dynamics of malaria in natural setting which is comprised of pregnant women and other individuals. Some weather conditions are also considered in the model. The main importance is to investigate the evolution of various states involved in the transmission of malaria in the community. The model equilibria are analyzed to study their stability, and numerical solution of the system is presented and discussed. The result shows that …

Evaluation Of Antibacterial Activity For Aqueous Exteracted Combination Of Triphala And Aloe-Vera Against Streptoccocus Oralis: (In Vitro Study), Abbas Hussein Irrihaim, Maha Abdul-Aziz Ahmed

Muthanna Medical Journal

Background: Streptoccocus Oralis is an early colonizer in dental biofilm and contributes to plaque formation and periodontal inflammation. The search for safe, natural antimicrobial alternatives has increased interest in herbal agents such as Triphala and Aloe vera. However, their combined activity against S. oralis has not been fully assessed alongside phytochemical profiling.

Aim: To evaluate the antibacterial activity of aqueous-extracted Triphala, Aloe vera, and their combination against S. oralis, including inhibition zone measurement, MIC, MBC, and HPLC characterization. Materials and Methods: Aloe vera gel and Triphala powder were extracted using aqueous extraction and freeze-drying. Antibacterial activity was assessed using …

Proportion Of Uti And Associated Risk Factors Among Young Female Medical Students In The Age Group 17-25 Years In An Educational Institution In South Kerala, Maria Thomas Tressa, Prasanand S, Ajas Sn

Muthanna Medical Journal

Background: Urinary tract infections (UTIs) are the second most common infection in women and frequently recur in young hostel-dwelling females. This study aims to estimate the Proportion of UTI and identify associated behavioural and hygiene-related risk factors among female medical students aged 17–25 years. Methods: An institution-based cross-sectional analytical study was conducted from August to October 2024 at Dr. Somervell Memorial C.S.I. Medical College, Karakonam. Sample size of 139 was calculated using Proportion of 40.8% with 8% precision. All eligible female students were included after written informed consent. A pre-tested, semi-structured questionnaire was used. Data were analysed using …

Immune Checkpoint Inhibition In Relapsed Or Refractory Hodgkin Lymphoma: A U.S. Cohort Analysis, Daniel R. Whitman, Emily K. Patterson, Jonathan M. Reyes, Laura B. Chen

Muthanna Medical Journal

Background: Relapsed or refractory classical Hodgkin lymphoma (cHL) remains a therapeutic challenge, particularly in patients who progress after multiple lines of therapy or autologous stem cell transplantation (ASCT). Immune checkpoint inhibitors targeting the programmed death-1 (PD-1) pathway have demonstrated substantial activity in clinical trials; however, real-world outcomes in routine clinical practice across heterogeneous patient populations in the United States remain limited. This study evaluated the effectiveness and safety of PD-1 blockade in patients with relapsed or refractory cHL treated in a U.S. cohort. Methods: We conducted a retrospective multicenter cohort study including adult patients (≥ 18 years) with histologically confirmed …

Autistic Traits And Mind Wandering: A Correlational Study Of Themes, Intentionality, And Temporal Focus, Leilani Forby, Farid Pazhoohi, Alan Kingstone

School of Psychology

There is abundant research on the nature and content of mind wandering (MW) in neurotypical individuals, yet little research in these areas on individuals high in autistic traits. The current study explored the relationship between autistic traits and several aspects of MW: themes, intentionality, temporal dimensions, and attitudes towards MW. A total of 1,477 participants completed measures of autistic traits, MW, and stress. Autistic trait level was positively correlated with the MW theme of guilt and fear of failure (GFF), spontaneous MW (MW-S), poor attentional control (PAC), and stress, and negatively correlated with appreciation for MW’s benefits. Participants were then …